Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IPO13	9670	broad.mit.edu	37	1	44423086	44423086	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr1:44423086C>A	uc001ckx.2	+	7	2200	c.1405C>A	c.(1405-1407)CTC>ATC	p.L469I		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	469	HEAT 7.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CACAGAGGCCCTCCTCTACGG	0.572													48	14					5.73435e-26	6.48887e-26	0.048971	1	0
RRP15	51018	broad.mit.edu	37	1	218480910	218480910	+	Missense_Mutation	SNP	T	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr1:218480910T>G	uc001hlj.2	+	4	671	c.641T>G	c.(640-642)TTG>TGG	p.L214W		NM_016052	NP_057136	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog	214						mitochondrion|nucleolus	protein binding				0				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		ATCAGTGTTTTGAGAGGGATG	0.373													21	4					0	0	0.062417	0	0
GALNT2	2590	broad.mit.edu	37	1	230385000	230385000	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr1:230385000C>A	uc010pwa.1	+	9	960	c.888C>A	c.(886-888)AAC>AAA	p.N296K	GALNT2_uc010pvy.1_Missense_Mutation_p.N258K|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	296	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GGCAGGGGAACCCAGTCGCCC	0.567													17	11					1.15088e-07	1.21691e-07	0.028581	1	0
RGS7	6000	broad.mit.edu	37	1	241094065	241094065	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr1:241094065G>C	uc001hyv.2	-	6	667	c.337C>G	c.(337-339)CCC>GCC	p.P113A	RGS7_uc010pyh.1_Missense_Mutation_p.P87A|RGS7_uc010pyj.1_Missense_Mutation_p.P29A|RGS7_uc001hyu.2_Missense_Mutation_p.P113A|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Missense_Mutation_p.P113A	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	113					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CAAAAATAGGGGGTCTGCGGA	0.383													62	12					0	0	0.048971	0	0
OR2T3	343173	broad.mit.edu	37	1	248637256	248637256	+	Missense_Mutation	SNP	C	T	T	rs79885009	byFrequency	TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr1:248637256C>T	uc001iel.1	+	1	605	c.605C>T	c.(604-606)ACG>ATG	p.T202M		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCTATAAGACGCTCATGTAC	0.507													5	26					0	0	0.021553	0	0
MLLT10	8028	broad.mit.edu	37	10	22022934	22022934	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr10:22022934A>T	uc001iqs.2	+	21	3130	c.2782A>T	c.(2782-2784)ATT>TTT	p.I928F	MLLT10_uc001iqt.2_Missense_Mutation_p.I912F|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.I912F|MLLT10_uc001ira.2_Missense_Mutation_p.I369F|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	928					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						AATTAATGGCATTGTAGGAGC	0.498			T	MLL|PICALM|CDK6	AL								33	40					0	0	0.041601	0	0
ANXA11	311	broad.mit.edu	37	10	81927005	81927005	+	Missense_Mutation	SNP	A	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr10:81927005A>C	uc001kbq.1	-	7	1451	c.626T>G	c.(625-627)CTG>CGG	p.L209R	ANXA11_uc010qlx.1_Missense_Mutation_p.L309R|ANXA11_uc001kbr.1_Missense_Mutation_p.L209R|ANXA11_uc001kbs.1_Missense_Mutation_p.L209R|ANXA11_uc001kbt.1_Missense_Mutation_p.L209R|ANXA11_uc010qly.1_Missense_Mutation_p.L176R|ANXA11_uc009xsq.1_Missense_Mutation_p.L209R|ANXA11_uc001kbu.1_Missense_Mutation_p.L209R	NM_145869	NP_665876	P50995	ANX11_HUMAN	annexin A11	209	Annexin 1.				cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			ovary(1)	1	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			GGCCTTCCGCAGGACCTCGGC	0.577													25	25					0	0	0.030593	0	0
PSTK	118672	broad.mit.edu	37	10	124740205	124740205	+	Silent	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr10:124740205A>G	uc001lgy.1	+	1	650	c.210A>G	c.(208-210)CGA>CGG	p.R70R		NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	70							ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		CAAGAGCGCGACCGGCGGTCA	0.577											OREG0020597	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	5					0	0	0.009096	0	0
SLC43A1	8501	broad.mit.edu	37	11	57256737	57256737	+	Missense_Mutation	SNP	T	C	C	rs116416099	by1000genomes	TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr11:57256737T>C	uc001nkk.2	-	12	1440	c.1322A>G	c.(1321-1323)AAC>AGC	p.N441S	SLC43A1_uc001nkl.2_Missense_Mutation_p.N441S	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	441					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						GAGGTGTAAGTTGTTGATGAG	0.567													34	52					0	0	0.050027	0	0
INCENP	3619	broad.mit.edu	37	11	61912744	61912744	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr11:61912744G>A	uc001nsw.1	+	13	2021	c.1819G>A	c.(1819-1821)GAC>AAC	p.D607N	INCENP_uc009ynw.1_Missense_Mutation_p.D607N|INCENP_uc001nsx.1_Missense_Mutation_p.D603N|INCENP_uc001nsy.1_Missense_Mutation_p.D17N	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	607	Potential.				chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						TGCTCAGATCGACGAGAAGAC	0.582													44	51					0	0	0.036044	0	0
EED	8726	broad.mit.edu	37	11	85956385	85956385	+	Missense_Mutation	SNP	T	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr11:85956385T>A	uc001pbp.2	+	1	571	c.114T>A	c.(112-114)AAT>AAA	p.N38K	EED_uc010rtm.1_Missense_Mutation_p.N38K|EED_uc001pbq.2_Missense_Mutation_p.N38K|EED_uc001pbr.2_Missense_Mutation_p.N38K|EED_uc001pbs.2_Missense_Mutation_p.N38K	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	38					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GAGACGAGAATGTAAGTGCAG	0.572													17	18					0	0	0.028581	0	0
SLC35F2	54733	broad.mit.edu	37	11	107677532	107677532	+	Missense_Mutation	SNP	A	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr11:107677532A>C	uc001pjq.2	-	4	906	c.485T>G	c.(484-486)GTG>GGG	p.V162G	SLC35F2_uc010rvu.1_Missense_Mutation_p.V14G|SLC35F2_uc001pjs.2_Missense_Mutation_p.V162G	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	162					transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		GAAGTGGATCACTCTGTATCT	0.463													23	43					0	0	0.021523	0	0
SLC6A12	6539	broad.mit.edu	37	12	308019	308019	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:308019A>T	uc001qhz.2	-	9	1333	c.790T>A	c.(790-792)TAC>AAC	p.Y264N	SLC6A12_uc001qhx.2_5'UTR|SLC6A12_uc001qhy.2_5'UTR|SLC6A12_uc001qia.2_Missense_Mutation_p.Y264N|SLC6A12_uc001qib.2_Missense_Mutation_p.Y264N|SLC6A12_uc009zdh.1_Missense_Mutation_p.Y264N	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	264					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			ATGCCCTGGTAGGCTCCGGGA	0.562													63	56					0	0	0.048971	0	0
KDM5A	5927	broad.mit.edu	37	12	401948	401948	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:401948A>G	uc001qif.1	-	27	5206	c.4843T>C	c.(4843-4845)TGC>CGC	p.C1615R	KDM5A_uc001qie.1_Missense_Mutation_p.C1620R	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1615	PHD-type 3.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						GGCCTTTGGCAGTTCTGTGCT	0.468			T 	NUP98	AML								43	90					0	0	0.042209	0	0
C12orf5	57103	broad.mit.edu	37	12	4461705	4461705	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:4461705C>G	uc001qmp.2	+	6	740	c.661C>G	c.(661-663)CTG>GTG	p.L221V		NM_020375	NP_065108	Q9NQ88	TIGAR_HUMAN	TP53-induced glycolysis and apoptosis regulator	221						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			skin(1)	1			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			ACCAGCCACTCTGAGCAGATC	0.423													46	55					0	0	0.045515	0	0
GPR162	27239	broad.mit.edu	37	12	6933600	6933600	+	Missense_Mutation	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:6933600T>C	uc001qqw.1	+	2	1071	c.536T>C	c.(535-537)TTT>TCT	p.F179S	GPR162_uc010sfn.1_Missense_Mutation_p.F179S|GPR162_uc001qqx.1_Intron|GPR162_uc009zfd.1_Intron|GPR162_uc001qqy.1_5'Flank	NM_019858	NP_062832	Q16538	GP162_HUMAN	G protein-coupled receptor 162 isoform 2	179	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCCTCGGCTTTGGCGTTTGC	0.597													33	53					0	0	0.064281	0	0
DDX12	440081	broad.mit.edu	37	12	9573224	9573224	+	Missense_Mutation	SNP	C	T	T	rs7358609	by1000genomes	TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:9573224C>T	uc010sgs.1	-	21	2284	c.2089G>A	c.(2089-2091)GGT>AGT	p.G697S	DDX12_uc001qvx.3_5'Flank|DDX12_uc001qvy.1_5'Flank	NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						GAAACCACACCGCACAGGTTA	0.483													4	66					0	0	0.014758	0	0
ITPR2	3709	broad.mit.edu	37	12	26809443	26809443	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:26809443C>G	uc001rhg.2	-	19	2648	c.2231G>C	c.(2230-2232)CGC>CCC	p.R744P		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	744	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CAGATACTGGCGATCCAAGCA	0.453													25	53					0	0	0.021523	0	0
DIP2B	57609	broad.mit.edu	37	12	51092173	51092173	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:51092173A>G	uc001rwv.2	+	18	2267	c.2111A>G	c.(2110-2112)TAT>TGT	p.Y704C	DIP2B_uc009zlt.2_Missense_Mutation_p.Y134C	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	704						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GGATTGAGCTATGGGGTAATA	0.463													36	62					0	0	0.064281	0	0
ESPL1	9700	broad.mit.edu	37	12	53680427	53680427	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:53680427C>A	uc001sck.2	+	18	3998	c.3907C>A	c.(3907-3909)CCT>ACT	p.P1303T	ESPL1_uc001scj.2_Missense_Mutation_p.P978T|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1303					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						AAAAAGTGTCCCTGGCTCAGA	0.527													33	33					9.65963e-10	1.02983e-09	0.059317	1	0
RDH5	5959	broad.mit.edu	37	12	56115258	56115258	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:56115258A>G	uc001shk.2	+	2	473	c.290A>G	c.(289-291)GAG>GGG	p.E97G	BLOC1S1_uc001shj.3_Intron|RDH5_uc010spt.1_Missense_Mutation_p.E97G|RDH5_uc010spu.1_5'UTR|RDH5_uc001shl.2_Missense_Mutation_p.E97G	NM_002905	NP_002896	Q92781	RDH1_HUMAN	retinol dehydrogenase 5 (11-cis and 9-cis)	97					response to stimulus|visual perception	membrane	binding|retinol dehydrogenase activity			ovary(1)	1					NADH(DB00157)|Vitamin A(DB00162)	AAGTGGGTGGAGATGCACGTT	0.612													34	53					0	0	0.069456	0	0
GLIPR1L2	144321	broad.mit.edu	37	12	75785104	75785104	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:75785104C>A	uc001sxr.1	+	1	216	c.208C>A	c.(208-210)CCC>ACC	p.P70T	CAPS2_uc001sxm.3_5'Flank|CAPS2_uc009zsa.2_5'Flank|GLIPR1L2_uc001sxp.1_Missense_Mutation_p.P70T|GLIPR1L2_uc001sxq.1_5'UTR	NM_152436	NP_689649	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	70						integral to membrane				ovary(1)	1						CGACGTCATTCCCCGAGGGTC	0.567											OREG0021999	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	34					8.73648e-17	9.71557e-17	0.069456	1	0
NCOR2	9612	broad.mit.edu	37	12	124887099	124887099	+	Silent	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr12:124887099T>C	uc010tba.1	-	14	1608	c.1491A>G	c.(1489-1491)CAA>CAG	p.Q497Q	NCOR2_uc010tay.1_Silent_p.Q497Q|NCOR2_uc010taz.1_Silent_p.Q497Q|NCOR2_uc010tbb.1_Silent_p.Q497Q|NCOR2_uc010tbc.1_Silent_p.Q496Q|NCOR2_uc001ugj.1_Silent_p.Q497Q	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	497	Poly-Gln.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		gctgctgttgttgctgctgct	0.353													3	3					0	0	0.004672	0	0
CUL4A	8451	broad.mit.edu	37	13	113915023	113915023	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr13:113915023C>G	uc010tjy.1	+	20	2145	c.2134C>G	c.(2134-2136)CAT>GAT	p.H712D	CUL4A_uc010tjx.1_Missense_Mutation_p.H612D|CUL4A_uc010agu.2_Missense_Mutation_p.H573D|CUL4A_uc010tjz.1_Missense_Mutation_p.H391D	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	712					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			GACTCTTGGTCATAATCTTCT	0.328													13	16					0	0	0.013537	0	0
LAMP1	3916	broad.mit.edu	37	13	113963979	113963979	+	Missense_Mutation	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr13:113963979T>C	uc001vtm.1	+	3	486	c.205T>C	c.(205-207)TCA>CCA	p.S69P	LAMP1_uc010tka.1_Missense_Mutation_p.S69P	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	69	Lumenal (Potential).|First lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			TGACCTGCCATCAGATGCCAC	0.423													40	65					0	0	0.025465	0	0
SDCCAG1	9147	broad.mit.edu	37	14	50292672	50292672	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr14:50292672G>A	uc001wxc.2	-	16	1558	c.1490C>T	c.(1489-1491)GCA>GTA	p.A497V	SDCCAG1_uc010anj.1_Missense_Mutation_p.A497V|SDCCAG1_uc010tqi.1_Missense_Mutation_p.A497V|SDCCAG1_uc001wxe.2_Missense_Mutation_p.A455V|SDCCAG1_uc001wxd.1_5'UTR|SDCCAG1_uc010anq.1_Missense_Mutation_p.A268V	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	497						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		TGACTTGAATGCCTATTTATA	0.269													15	5					0	0	0.028581	0	0
MYO5A	4644	broad.mit.edu	37	15	52606371	52606371	+	Silent	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr15:52606371T>C	uc002aby.2	-	40	5608	c.5364A>G	c.(5362-5364)CCA>CCG	p.P1788P	MYO5A_uc002abx.3_Silent_p.P1761P|MYO5A_uc010ugd.1_Silent_p.P510P	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1788	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		ACTCATTAACTGGAGTATACA	0.348													26	45					0	0	0.024334	0	0
SRRM2	23524	broad.mit.edu	37	16	2812806	2812806	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr16:2812806C>G	uc002crk.2	+	11	2826	c.2277C>G	c.(2275-2277)AGC>AGG	p.S759R	SRRM2_uc002crj.1_Missense_Mutation_p.S663R|SRRM2_uc002crl.1_Missense_Mutation_p.S759R|SRRM2_uc010bsu.1_Missense_Mutation_p.S663R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	759	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CAAGGCGGAGCAGGTCTCTCT	0.473													156	109					0	0	0.048971	0	0
PRKCB	5579	broad.mit.edu	37	16	23848699	23848699	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr16:23848699C>T	uc002dmd.2	+	2	374	c.177C>T	c.(175-177)GGC>GGT	p.G59G	PRKCB_uc002dme.2_Silent_p.G59G	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	59	Phorbol-ester/DAG-type 1.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TTTGCAGGGGCTTCGGGAAGC	0.552													176	118					0	0	0.048971	0	0
ZNF48	197407	broad.mit.edu	37	16	30408740	30408740	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr16:30408740G>C	uc002dya.1	+	2	228	c.169G>C	c.(169-171)GCT>CCT	p.A57P	ZNF48_uc002dxz.1_5'UTR	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGAAGATTTGGCTCCAGATCA	0.488													41	138					0	0	0.030466	0	0
ZC3H18	124245	broad.mit.edu	37	16	88653085	88653085	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr16:88653085C>T	uc002fky.2	+	3	881	c.681C>T	c.(679-681)TTC>TTT	p.F227F	ZC3H18_uc010voy.1_Silent_p.F110F|ZC3H18_uc010voz.1_Silent_p.F227F|ZC3H18_uc010vpa.1_Silent_p.F227F	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	227	C3H1-type.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		GCCGGTTCTTCATGAAAGGTA	0.587													17	48					0	0	0.033300	0	0
SAT2	112483	broad.mit.edu	37	17	7530935	7530935	+	Nonsense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr17:7530935G>A	uc002gic.2	-	1	260	c.19C>T	c.(19-21)CGA>TGA	p.R7*	SHBG_uc010cmo.2_Intron|SHBG_uc010cmp.2_Intron|SHBG_uc010cmq.2_Intron|SHBG_uc010cmr.2_Intron|SHBG_uc010cms.2_Intron|SHBG_uc010cmt.2_Intron|SHBG_uc010cmu.2_Intron|SAT2_uc002gib.1_RNA|SHBG_uc010cmz.2_5'Flank|SHBG_uc010cmv.2_5'Flank|SHBG_uc010cmw.2_5'Flank|SHBG_uc010cmx.2_5'Flank|SHBG_uc010cmy.2_5'Flank|SHBG_uc002gid.3_5'Flank|SHBG_uc002gie.2_5'Flank|SHBG_uc010cnd.2_5'Flank|SHBG_uc010cna.2_5'Flank|SHBG_uc010vue.1_5'Flank|SHBG_uc010vuf.1_5'Flank|SHBG_uc010cnb.2_5'Flank|SHBG_uc010cnc.2_5'Flank	NM_133491	NP_597998	Q96F10	SAT2_HUMAN	diamine N-acetyltransferase 2	7	N-acetyltransferase.					cytoplasm	diamine N-acetyltransferase activity	p.?(1)			0				READ - Rectum adenocarcinoma(115;0.166)	Spermine(DB00127)	TTGGCCTCTCGGATCCGCACG	0.632													15	33					0	0	0.033300	0	0
TOP3A	7156	broad.mit.edu	37	17	18181411	18181411	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr17:18181411G>A	uc002gsx.1	-	18	2634	c.2405C>T	c.(2404-2406)CCC>CTC	p.P802L	TOP3A_uc010cpz.1_Missense_Mutation_p.P254L|TOP3A_uc010vxr.1_Missense_Mutation_p.P332L|TOP3A_uc002gsw.1_Missense_Mutation_p.P254L|TOP3A_uc010vxs.1_Missense_Mutation_p.P700L	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	802					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						AGCAGCCGTGGGTGGTGGGAG	0.627													41	65					0	0	0.025465	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904139	21904139	+	RNA	SNP	T	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr17:21904139T>G	uc002gza.2	+	1		c.78T>G				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						ccgagcaggatgaggaaacca	0													4	68					0	0	0.014758	0	0
MRO	83876	broad.mit.edu	37	18	48331527	48331527	+	Silent	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr18:48331527A>G	uc002lew.3	-	5	720	c.426T>C	c.(424-426)GAT>GAC	p.D142D	MRO_uc010xdn.1_Silent_p.D142D|MRO_uc010dpa.2_Silent_p.D156D|MRO_uc010dpb.2_Silent_p.D156D|MRO_uc010dpc.2_Silent_p.D142D|MRO_uc002lex.3_Silent_p.D142D	NM_031939	NP_114145	Q9BYG7	MSTRO_HUMAN	maestro isoform a	142	HEAT.					nucleolus	binding				0		Colorectal(6;0.0596)		Colorectal(21;0.082)		TACTTACGTCATCTAATAAAG	0.338													9	48					0	0	0.034045	0	0
LINGO3	645191	broad.mit.edu	37	19	2290213	2290213	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:2290213C>T	uc010dsx.1	-	2	1691	c.1563G>A	c.(1561-1563)CCG>CCA	p.P521P	SPPL2B_uc010dsw.1_Intron|uc002lvo.1_5'UTR	NM_001101391	NP_001094861	P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	521	Extracellular (Potential).					integral to membrane					0						TGAGGTCGAGCGGCGCGCGCA	0.706													18	30					0	0	0.062417	0	0
ZNF557	79230	broad.mit.edu	37	19	7075688	7075688	+	Silent	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:7075688C>G	uc002mgb.2	+	4	518	c.33C>G	c.(31-33)GCC>GCG	p.A11A	ZNF557_uc002mga.2_Silent_p.A18A|ZNF557_uc002mgc.2_Silent_p.A18A	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		TGTTCCCAGCCTCTCAGCGAG	0.532													41	52					0	0	0.048971	0	0
CACNA1A	773	broad.mit.edu	37	19	13346025	13346025	+	Nonsense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:13346025G>A	uc010dze.2	-	33	5370	c.5134C>T	c.(5134-5136)CAG>TAG	p.Q1712*	CACNA1A_uc010xnd.1_Nonsense_Mutation_p.Q417*|CACNA1A_uc002mwx.3_Nonsense_Mutation_p.Q417*|CACNA1A_uc010dzc.2_Nonsense_Mutation_p.Q1237*|CACNA1A_uc002mwy.3_Nonsense_Mutation_p.Q1711*|CACNA1A_uc002mwv.3_Nonsense_Mutation_p.Q228*	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1712	Extracellular (Potential).|IV.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACACTCACCTGCATCCCAATG	0.557											OREG0025293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	10					0	0	0.014758	0	0
ZNF461	92283	broad.mit.edu	37	19	37147417	37147417	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:37147417G>C	uc002oem.2	-	4	393	c.165C>G	c.(163-165)ATC>ATG	p.I55M	ZNF461_uc002oen.2_Missense_Mutation_p.I24M|ZNF461_uc010xtj.1_Missense_Mutation_p.I55M	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CCAATGAGGAGATTACGGCTG	0.443													30	36					0	0	0.037714	0	0
RYR1	6261	broad.mit.edu	37	19	39058443	39058443	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:39058443C>T	uc002oit.2	+	93	13675	c.13545C>T	c.(13543-13545)CCC>CCT	p.P4515P	RYR1_uc002oiu.2_Silent_p.P4510P	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4515	Pro-rich.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AAGAAGTTCCCGAGCCCACAC	0.557													20	51					0	0	0.062417	0	0
ERCC2	2068	broad.mit.edu	37	19	45868315	45868315	+	Silent	SNP	G	A	A	rs139263710		TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:45868315G>A	uc002pbj.2	-	6	509	c.462C>T	c.(460-462)CAC>CAT	p.H154H	ERCC2_uc010ejz.2_Intron|ERCC2_uc002pbk.2_Silent_p.H130H|ERCC2_uc002pbl.3_Silent_p.H130H|ERCC2_uc010xxj.1_Intron	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	154	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		AGAATCGGCAGTGGGGCAGGC	0.637			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				20	24					0	0	0.062417	0	0
ZNF321	399669	broad.mit.edu	37	19	53432286	53432286	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:53432286A>G	uc010eqj.2	-	4	694	c.524T>C	c.(523-525)TTG>TCG	p.L175S	ZNF321_uc002qaj.1_Missense_Mutation_p.L122S|ZNF321_uc002qak.1_Missense_Mutation_p.L175S	NM_203307	NP_976052			zinc finger protein 321												0				GBM - Glioblastoma multiforme(134;0.0305)		TTGGGATGTCAAAATTAAGGA	0.373													82	98					0	0	0.048971	0	0
NLRP9	338321	broad.mit.edu	37	19	56244868	56244868	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:56244868A>T	uc002qly.2	-	2	357	c.329T>A	c.(328-330)ATA>AAA	p.I110K		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	110						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CTTCTCCCATATGAGTTGAAA	0.363													44	58					0	0	0.048971	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:58385546G>T	uc002qqo.2	-	3	1484	c.1212C>A	c.(1210-1212)GAC>GAA	p.D404E	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						AATGTTTTTTGTCAGTGTGAA	0.393													3	13					6.4e-05	6.7122e-05	0.004672	1	0
MZF1	7593	broad.mit.edu	37	19	59073766	59073766	+	Missense_Mutation	SNP	G	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr19:59073766G>T	uc002qto.2	-	6	2439	c.1878C>A	c.(1876-1878)CAC>CAA	p.H626Q	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Missense_Mutation_p.H626Q	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	626	C2H2-type 10.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		ACTCACCGCAGTGGTAGGGCT	0.682													10	5					0.000673444	0.000694994	0.069234	1	0
MYADML	151325	broad.mit.edu	37	2	33952621	33952621	+	Silent	SNP	G	A	A	rs11684598	by1000genomes	TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr2:33952621G>A	uc002rpb.2	-	1	664	c.222C>T	c.(220-222)TAC>TAT	p.Y74Y		NR_003143				RecName: Full=Myeloid-associated differentiation marker-like protein.;												0						CTTCGGTGGCGTAAGCCACAC	0.647													3	26					0	0	0.004672	0	0
PSME4	23198	broad.mit.edu	37	2	54176408	54176408	+	Silent	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr2:54176408A>G	uc002rxp.2	-	2	311	c.255T>C	c.(253-255)CTT>CTC	p.L85L	PSME4_uc010yop.1_5'UTR|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_5'UTR	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	85					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TTCTCCCATAAAGTCGAatat	0.179													9	23					0	0	0.047766	0	0
CHRNA1	1134	broad.mit.edu	37	2	175624262	175624262	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr2:175624262A>T	uc002ujd.2	-	2	221	c.143T>A	c.(142-144)GTC>GAC	p.V48D	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Missense_Mutation_p.V48D|CHRNA1_uc002ujf.3_Missense_Mutation_p.V48D	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	48	Extracellular.				muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GACCTCCACGACCTGGCGGTG	0.617													77	150					0	0	0.048971	0	0
SLC40A1	30061	broad.mit.edu	37	2	190428363	190428363	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr2:190428363A>T	uc002uqp.3	-	7	1700	c.1349T>A	c.(1348-1350)GTG>GAG	p.V450E		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	450	Helical; (Potential).				anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			GATTATGGGCACAGATTCAGG	0.368													37	48					0	0	0.069456	0	0
HECW2	57520	broad.mit.edu	37	2	197187250	197187250	+	Missense_Mutation	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr2:197187250C>T	uc002utm.1	-	7	1019	c.836G>A	c.(835-837)GGG>GAG	p.G279E	HECW2_uc002utl.1_5'UTR	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	279	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GGTTAGTTTCCCCAGAAAACG	0.413													67	96					0	0	0.048971	0	0
ABCB6	10058	broad.mit.edu	37	2	220075814	220075814	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr2:220075814A>G	uc002vkc.1	-	15	2262	c.1985T>C	c.(1984-1986)CTC>CCC	p.L662P	ABCB6_uc010fwe.1_Missense_Mutation_p.L616P	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	662	ABC transporter.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGAGACCGGAGAGAGGCCTG	0.468													43	69					0	0	0.048971	0	0
CPXM1	56265	broad.mit.edu	37	20	2776796	2776796	+	Silent	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr20:2776796C>G	uc002wgu.2	-	10	1318	c.1254G>C	c.(1252-1254)CTG>CTC	p.L418L	CPXM1_uc010gas.2_Silent_p.L418L	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	418					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						CCCAGCCCACCAGCTCTGAAC	0.602													29	49					0	0	0.027356	0	0
TPTE	7179	broad.mit.edu	37	21	11014987	11014987	+	RNA	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr21:11014987A>G	uc002yis.1	-	7		c.1459T>C						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTATAGTTTCAATAGCAGACT	0.388													3	31					0	0	0.004672	0	0
HUNK	30811	broad.mit.edu	37	21	33371363	33371363	+	Missense_Mutation	SNP	A	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr21:33371363A>C	uc002yph.2	+	11	2371	c.2011A>C	c.(2011-2013)ATG>CTG	p.M671L		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	671					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						CATCGGACAGATGTTAAGGAA	0.617													36	67					0	0	0.054565	0	0
MICAL3	57553	broad.mit.edu	37	22	18293513	18293513	+	Missense_Mutation	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr22:18293513T>C	uc002zng.3	-	28	5865	c.5512A>G	c.(5512-5514)AGA>GGA	p.R1838G	MICAL3_uc011agl.1_Missense_Mutation_p.R1754G|MICAL3_uc010gre.1_RNA	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1838	Potential.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		TTGGCCTGTCTCCGAGCTGCC	0.572													22	40					0	0	0.076483	0	0
MTMR3	8897	broad.mit.edu	37	22	30413918	30413918	+	Silent	SNP	G	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr22:30413918G>T	uc003agv.3	+	16	2005	c.1677G>T	c.(1675-1677)GTG>GTT	p.V559V	MTMR3_uc003agu.3_Silent_p.V559V|MTMR3_uc003agw.3_Silent_p.V559V	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	559	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			CTCCTCAGGTGCTGTACCCTG	0.552													50	99					2.55665e-31	2.91865e-31	0.048971	1	0
POLR2F	5435	broad.mit.edu	37	22	38355418	38355418	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr22:38355418C>G	uc003aul.2	+	3	277	c.156C>G	c.(154-156)ATC>ATG	p.I52M	POLR2F_uc010gxi.2_Missense_Mutation_p.H46D|POLR2F_uc003aum.2_RNA	NM_021974	NP_068809	P61218	RPAB2_HUMAN	DNA directed RNA polymerase II polypeptide F	52					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)	1	Melanoma(58;0.045)					AGAAGCGAATCACCACACCAT	0.577													92	123					0	0	0.048971	0	0
KDELR3	11015	broad.mit.edu	37	22	38875733	38875733	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr22:38875733A>G	uc003avv.2	+	3	484	c.328A>G	c.(328-330)AAC>GAC	p.N110D	KDELR3_uc003avu.2_Missense_Mutation_p.N110D	NM_006855	NP_006846	O43731	ERD23_HUMAN	KDEL receptor 3 isoform a	110	Helical; (Potential).				protein retention in ER lumen|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	ER retention sequence binding|receptor activity			ovary(2)	2	Melanoma(58;0.0286)					CTTCCTTGAAAACTACAGTTT	0.473													146	182					0	0	0.048971	0	0
SEC13	6396	broad.mit.edu	37	3	10342967	10342967	+	Missense_Mutation	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr3:10342967T>C	uc003bvn.2	-	9	1066	c.947A>G	c.(946-948)GAG>GGG	p.E316G	SEC13_uc003bvl.2_Missense_Mutation_p.E248G|SEC13_uc003bvm.2_Missense_Mutation_p.E302G|SEC13_uc003bvp.2_Missense_Mutation_p.E319G|SEC13_uc003bvo.2_Missense_Mutation_p.E362G|SEC13_uc003bvq.1_Intron	NM_183352	NP_899195	P55735	SEC13_HUMAN	SEC13 protein isoform 1	316					COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			ovary(1)	1						CTGCTGGCCCTCTGTCACTGA	0.612													33	50					0	0	0.054565	0	0
MLH1	4292	broad.mit.edu	37	3	37042512	37042512	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr3:37042512G>A	uc003cgl.2	+	3	334	c.274G>A	c.(274-276)GCC>ACC	p.A92T	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Missense_Mutation_p.A92T|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_5'UTR|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	92					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TGAGGATTTAGCCAGTATTTC	0.348		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				34	32					0	0	0.023175	0	0
XYLB	9942	broad.mit.edu	37	3	38404484	38404484	+	Silent	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr3:38404484C>G	uc003cic.2	+	4	376	c.267C>G	c.(265-267)GTC>GTG	p.V89V	XYLB_uc011ayp.1_Intron|XYLB_uc003cid.1_Silent_p.V11V	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	89					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TCTCTCAAGTCCTAGCCTTGT	0.532													39	55					0	0	0.033182	0	0
SLC38A3	10991	broad.mit.edu	37	3	50257565	50257565	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr3:50257565A>G	uc003cyn.3	+	16	1612	c.1471A>G	c.(1471-1473)ATT>GTT	p.I491V		NM_006841	NP_006832	Q99624	S38A3_HUMAN	solute carrier family 38, member 3	491	Helical; (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	CTTCATCATCATTGACTGGGC	0.557													10	3					0	0	0.058154	0	0
LOC285359	285359	broad.mit.edu	37	3	101432120	101432120	+	RNA	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr3:101432120C>G	uc003dvj.2	+	1		c.843C>G				NR_002941				Homo sapiens cDNA FLJ12205 fis, clone MAMMA1000931.												0						ATGAATCCTTCTGGTTTTTAG	0.299													3	9					0	0	0.004672	0	0
ABHD10	55347	broad.mit.edu	37	3	111700691	111700691	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr3:111700691A>G	uc003dyk.3	+	2	284	c.203A>G	c.(202-204)TAT>TGT	p.Y68C	ABHD10_uc011bhq.1_Intron	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	68						mitochondrion	serine-type peptidase activity				0						AACCTGGCTTATAAGAAGCTA	0.378													53	68					0	0	0.048971	0	0
EEFSEC	60678	broad.mit.edu	37	3	127981023	127981023	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr3:127981023G>C	uc003eki.2	+	3	615	c.577G>C	c.(577-579)GCC>CCC	p.A193P	EEFSEC_uc003ekj.2_Missense_Mutation_p.A193P	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	193						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GGGACCAGAGGCCCCCGAAAC	0.562													68	82					0	0	0.048971	0	0
ZMAT3	64393	broad.mit.edu	37	3	178785387	178785387	+	Nonsense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr3:178785387C>A	uc003fjg.2	-	2	413	c.154G>T	c.(154-156)GAG>TAG	p.E52*	ZMAT3_uc010hxa.2_Nonsense_Mutation_p.E52*|ZMAT3_uc003fji.2_Nonsense_Mutation_p.E52*	NM_022470	NP_071915	Q9HA38	ZMAT3_HUMAN	p53 target zinc finger protein isoform 1	52					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			ovary(2)	2	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			TTCGATAACTCTTCTTCCCCT	0.552													41	72					2.26627e-22	2.54217e-22	0.030466	1	0
CLPTM1L	81037	broad.mit.edu	37	5	1324927	1324927	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr5:1324927A>T	uc003jch.2	-	11	1194	c.1148T>A	c.(1147-1149)TTT>TAT	p.F383Y	CLPTM1L_uc003jcg.2_Missense_Mutation_p.F214Y	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like	383	Cytoplasmic (Potential).				apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		GTAAGTGCCAAACTGTTGTGA	0.488													37	44					0	0	0.074837	0	0
RGNEF	64283	broad.mit.edu	37	5	73205322	73205322	+	Missense_Mutation	SNP	T	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr5:73205322T>A	uc011csq.1	+	33	4258	c.4247T>A	c.(4246-4248)ATC>AAC	p.I1416N	RGNEF_uc003kcx.2_Missense_Mutation_p.I1416N|RGNEF_uc010izf.2_Missense_Mutation_p.I1416N|RGNEF_uc011csr.1_Missense_Mutation_p.I1103N|RGNEF_uc003kcz.3_Missense_Mutation_p.I380N|RGNEF_uc003kda.3_Missense_Mutation_p.I336N	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	1416					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		GGCCACTCTATCCTCCGAGGC	0.622													9	10					0	0	0.058154	0	0
SEMA6A	57556	broad.mit.edu	37	5	115822558	115822558	+	Silent	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr5:115822558G>A	uc010jck.2	-	10	1558	c.849C>T	c.(847-849)TGC>TGT	p.C283C	SEMA6A_uc003krx.3_Silent_p.C283C	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	283	Sema.|Extracellular (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CAGGAACTGAGCAGTTCAAGC	0.463													50	70					0	0	0.048971	0	0
LOC153328	153328	broad.mit.edu	37	5	135178132	135178132	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr5:135178132C>A	uc003laz.1	+	2	246	c.74C>A	c.(73-75)CCT>CAT	p.P25H	LOC153328_uc003lba.2_Missense_Mutation_p.P25H			Q6ZT89	S2548_HUMAN	RecName: Full=Putative mitochondrial carrier protein FLJ44862;	25	Helical; Name=1; (Potential).|Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTGGCCACCCTCTGGACACA	0.507													58	106					8.27209e-15	9.12051e-15	0.048971	1	0
LOC153328	153328	broad.mit.edu	37	5	135207543	135207543	+	Missense_Mutation	SNP	G	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr5:135207543G>T	uc003laz.1	+	5	987	c.815G>T	c.(814-816)GGT>GTT	p.G272V	LOC153328_uc003lba.2_Intron			Q6ZT89	S2548_HUMAN	RecName: Full=Putative mitochondrial carrier protein FLJ44862;	Error:Variant_position_missing_in_Q6ZT89_after_alignment					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCTTTGTTAGGTACCTACTCT	0.542													27	29					2.12542e-12	2.28482e-12	0.030593	1	0
RANBP17	64901	broad.mit.edu	37	5	170323085	170323085	+	Missense_Mutation	SNP	T	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr5:170323085T>A	uc003mba.2	+	5	471	c.455T>A	c.(454-456)ATA>AAA	p.I152K	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_Intron|RANBP17_uc003maw.2_Missense_Mutation_p.I152K|RANBP17_uc011dew.1_Missense_Mutation_p.I152K	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	152					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATAGGAGTAATAATCCTTTCT	0.388			T	TRD@	ALL								40	52					0	0	0.027894	0	0
SLC17A4	10050	broad.mit.edu	37	6	25773825	25773825	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr6:25773825G>A	uc003nfe.2	+	8	1029	c.910G>A	c.(910-912)GAA>AAA	p.E304K	SLC17A4_uc011djx.1_Intron|SLC17A4_uc003nff.1_Missense_Mutation_p.E65K|SLC17A4_uc003nfg.2_Missense_Mutation_p.E241K|SLC17A4_uc010jqa.2_Missense_Mutation_p.E17K	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	304	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						TTATTTCTGTGAATACTGGCT	0.443													34	55					0	0	0.054565	0	0
MUC21	394263	broad.mit.edu	37	6	30955264	30955264	+	Missense_Mutation	SNP	T	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr6:30955264T>A	uc003nsh.2	+	2	1563	c.1312T>A	c.(1312-1314)TCT>ACT	p.S438T	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	438	Ser-rich.|28.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						AGCCACCAACTCTGGGTCCAG	0.577													71	96					0	0	0.048971	0	0
MCM3	4172	broad.mit.edu	37	6	52141973	52141973	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr6:52141973G>C	uc003pan.1	-	8	1167	c.1057C>G	c.(1057-1059)CAG>GAG	p.Q353E	MCM3_uc011dwu.1_Missense_Mutation_p.Q307E	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	353	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					CGCAGAAGCTGAGACTTGGCA	0.597													12	25					0	0	0.010729	0	0
KIAA1549	57670	broad.mit.edu	37	7	138597164	138597164	+	Missense_Mutation	SNP	A	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr7:138597164A>C	uc011kql.1	-	3	2970	c.2921T>G	c.(2920-2922)ATC>AGC	p.I974S	KIAA1549_uc003vuk.3_Missense_Mutation_p.I924S|KIAA1549_uc011kqj.1_Missense_Mutation_p.I974S	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	974						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TACTTCTTTGATTGCTGTAAT	0.463			O	BRAF	pilocytic astrocytoma								35	22					0	0	0.050027	0	0
ATP6V0E2	155066	broad.mit.edu	37	7	149576654	149576654	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr7:149576654C>G	uc003wgr.2	+	4	1550	c.599C>G	c.(598-600)CCG>CGG	p.P200R	ATP6V0E2_uc003wgs.2_Missense_Mutation_p.P177R|ATP6V0E2_uc003wgp.2_3'UTR|ATP6V0E2_uc003wgq.2_RNA|uc003wgt.1_5'Flank	NM_145230	NP_660265	Q8NHE4	VA0E2_HUMAN	ATPase, H+ transporting, V0 subunit isoform 1	Error:Variant_position_missing_in_Q8NHE4_after_alignment					ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuole	ATPase activity, coupled to transmembrane movement of ions|hydrogen ion transmembrane transporter activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00256)			CTCCAATACCCGCACTGCTCT	0.637													17	7					0	0	0.038395	0	0
LYN	4067	broad.mit.edu	37	8	56922610	56922610	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr8:56922610C>A	uc003xsk.3	+	13	1762	c.1480C>A	c.(1480-1482)CAG>AAG	p.Q494K	LYN_uc003xsl.3_Missense_Mutation_p.Q473K	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	494	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			TGACTACTTACAGAGCGTCCT	0.527													34	60					8.4185e-14	9.20328e-14	0.050027	1	0
GEM	2669	broad.mit.edu	37	8	95262646	95262646	+	Silent	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr8:95262646G>A	uc003ygj.2	-	5	1032	c.783C>T	c.(781-783)AGC>AGT	p.S261S	GEM_uc003ygi.2_Silent_p.S261S	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	261					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			TCCTGGGCATGCTCTCCTTCC	0.552													22	40					0	0	0.062417	0	0
OR13J1	392309	broad.mit.edu	37	9	35869823	35869823	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr9:35869823C>T	uc011lph.1	-	1	576	c.576G>A	c.(574-576)ACG>ACA	p.T192T		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			CGCTGACCGACGTGTTGCCGC	0.597													16	34					0	0	0.024245	0	0
SECISBP2	79048	broad.mit.edu	37	9	91965762	91965762	+	Missense_Mutation	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr9:91965762C>T	uc004aqj.1	+	14	2188	c.2108C>T	c.(2107-2109)TCA>TTA	p.S703L	SECISBP2_uc011ltk.1_Missense_Mutation_p.S702L|SECISBP2_uc004aqk.1_Missense_Mutation_p.S630L|SECISBP2_uc010mqo.1_Missense_Mutation_p.S408L|SECISBP2_uc011ltl.1_Missense_Mutation_p.S635L	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	703					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						AAGATACAGTCAAAAGGTAAA	0.498													30	32					0	0	0.034045	0	0
RAD23B	5887	broad.mit.edu	37	9	110091836	110091836	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr9:110091836G>A	uc004bde.2	+	10	1496	c.1129G>A	c.(1129-1131)GGA>AGA	p.G377R	RAD23B_uc011lwb.1_Missense_Mutation_p.G356R	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	377	UBA 2.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						AAAGGCATTAGGATTTCCTGA	0.328								Direct_reversal_of_damage|NER					28	58					0	0	0.037714	0	0
RABGAP1	23637	broad.mit.edu	37	9	125751642	125751642	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr9:125751642C>T	uc011lzh.1	+	5	791	c.657C>T	c.(655-657)GTC>GTT	p.V219V	RABGAP1_uc004bnl.3_RNA|RABGAP1_uc004bnm.1_Silent_p.V219V	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	219	PID.				cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						TCTTCTGTGTCAGAGGGCATG	0.413													41	43					0	0	0.027894	0	0
IPO13	9670	broad.mit.edu	37	1	44423086	44423086	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr1:44423086C>A	uc001ckx.2	+	7	2200	c.1405C>A	c.(1405-1407)CTC>ATC	p.L469I		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	469	HEAT 7.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CACAGAGGCCCTCCTCTACGG	0.572000													48	14					5.73435e-26	6.34874e-26	0.048971	1	0
NBPF9	400818	broad.mit.edu	37	1	144815968	144815968	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr1:144815968G>A	uc009wig.1	+	12	1415	c.1339G>A	c.(1339-1341)GTT>ATT	p.V447I	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.V447I|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF9_uc009wii.1_Missense_Mutation_p.V176I|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Missense_Mutation_p.V107I	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	447	NBPF 2.					cytoplasm					0						AGATGTTCAAGTTGAGGTGGC	0.423000													23	21					0	0	0.045705	0	0
RRP15	51018	broad.mit.edu	37	1	218480910	218480910	+	Missense_Mutation	SNP	T	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr1:218480910T>G	uc001hlj.2	+	4	671	c.641T>G	c.(640-642)TTG>TGG	p.L214W		NM_016052	NP_057136	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog	214						mitochondrion|nucleolus	protein binding				0				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		ATCAGTGTTTTGAGAGGGATG	0.373000													21	4					0	0	0.062417	0	0
GALNT2	2590	broad.mit.edu	37	1	230385000	230385000	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr1:230385000C>A	uc010pwa.1	+	9	960	c.888C>A	c.(886-888)AAC>AAA	p.N296K	GALNT2_uc010pvy.1_Missense_Mutation_p.N258K|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	296	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GGCAGGGGAACCCAGTCGCCC	0.567000													17	11					1.15088e-07	1.18924e-07	0.028581	1	0
RGS7	6000	broad.mit.edu	37	1	241094065	241094065	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr1:241094065G>C	uc001hyv.2	-	6	667	c.337C>G	c.(337-339)CCC>GCC	p.P113A	RGS7_uc010pyh.1_Missense_Mutation_p.P87A|RGS7_uc010pyj.1_Missense_Mutation_p.P29A|RGS7_uc001hyu.2_Missense_Mutation_p.P113A|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Missense_Mutation_p.P113A	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	113					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CAAAAATAGGGGGTCTGCGGA	0.383000													62	12					0	0	0.048971	0	0
OR2T3	343173	broad.mit.edu	37	1	248637256	248637256	+	Missense_Mutation	SNP	C	T	T	rs79885009	byFrequency	TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr1:248637256C>T	uc001iel.1	+	1	605	c.605C>T	c.(604-606)ACG>ATG	p.T202M		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCTATAAGACGCTCATGTAC	0.507000													5	26					0	0	0.021553	0	0
MLLT10	8028	broad.mit.edu	37	10	22022934	22022934	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr10:22022934A>T	uc001iqs.2	+	21	3130	c.2782A>T	c.(2782-2784)ATT>TTT	p.I928F	MLLT10_uc001iqt.2_Missense_Mutation_p.I912F|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.I912F|MLLT10_uc001ira.2_Missense_Mutation_p.I369F|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	928					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						AATTAATGGCATTGTAGGAGC	0.498000			T	MLL|PICALM|CDK6	AL								33	40					0	0	0.041601	0	0
ANXA11	311	broad.mit.edu	37	10	81927005	81927005	+	Missense_Mutation	SNP	A	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr10:81927005A>C	uc001kbq.1	-	7	1451	c.626T>G	c.(625-627)CTG>CGG	p.L209R	ANXA11_uc010qlx.1_Missense_Mutation_p.L309R|ANXA11_uc001kbr.1_Missense_Mutation_p.L209R|ANXA11_uc001kbs.1_Missense_Mutation_p.L209R|ANXA11_uc001kbt.1_Missense_Mutation_p.L209R|ANXA11_uc010qly.1_Missense_Mutation_p.L176R|ANXA11_uc009xsq.1_Missense_Mutation_p.L209R|ANXA11_uc001kbu.1_Missense_Mutation_p.L209R	NM_145869	NP_665876	P50995	ANX11_HUMAN	annexin A11	209	Annexin 1.				cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			ovary(1)	1	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			GGCCTTCCGCAGGACCTCGGC	0.577000													25	25					0	0	0.030593	0	0
PSTK	118672	broad.mit.edu	37	10	124740205	124740205	+	Silent	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr10:124740205A>G	uc001lgy.1	+	1	650	c.210A>G	c.(208-210)CGA>CGG	p.R70R		NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	70							ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		CAAGAGCGCGACCGGCGGTCA	0.577000											OREG0020597	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	5					0	0	0.009096	0	0
SLC43A1	8501	broad.mit.edu	37	11	57256737	57256737	+	Missense_Mutation	SNP	T	C	C	rs116416099	by1000genomes	TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr11:57256737T>C	uc001nkk.2	-	12	1440	c.1322A>G	c.(1321-1323)AAC>AGC	p.N441S	SLC43A1_uc001nkl.2_Missense_Mutation_p.N441S	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	441					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						GAGGTGTAAGTTGTTGATGAG	0.567000													34	52					0	0	0.050027	0	0
INCENP	3619	broad.mit.edu	37	11	61912744	61912744	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr11:61912744G>A	uc001nsw.1	+	13	2021	c.1819G>A	c.(1819-1821)GAC>AAC	p.D607N	INCENP_uc009ynw.1_Missense_Mutation_p.D607N|INCENP_uc001nsx.1_Missense_Mutation_p.D603N|INCENP_uc001nsy.1_Missense_Mutation_p.D17N	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	607	Potential.				chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						TGCTCAGATCGACGAGAAGAC	0.582000													44	51					0	0	0.036044	0	0
EED	8726	broad.mit.edu	37	11	85956385	85956385	+	Missense_Mutation	SNP	T	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr11:85956385T>A	uc001pbp.2	+	1	571	c.114T>A	c.(112-114)AAT>AAA	p.N38K	EED_uc010rtm.1_Missense_Mutation_p.N38K|EED_uc001pbq.2_Missense_Mutation_p.N38K|EED_uc001pbr.2_Missense_Mutation_p.N38K|EED_uc001pbs.2_Missense_Mutation_p.N38K	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	38					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GAGACGAGAATGTAAGTGCAG	0.572000													17	18					0	0	0.028581	0	0
SLC35F2	54733	broad.mit.edu	37	11	107677532	107677532	+	Missense_Mutation	SNP	A	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr11:107677532A>C	uc001pjq.2	-	4	906	c.485T>G	c.(484-486)GTG>GGG	p.V162G	SLC35F2_uc010rvu.1_Missense_Mutation_p.V14G|SLC35F2_uc001pjs.2_Missense_Mutation_p.V162G	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	162					transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		GAAGTGGATCACTCTGTATCT	0.463000													23	43					0	0	0.021523	0	0
SLC6A12	6539	broad.mit.edu	37	12	308019	308019	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:308019A>T	uc001qhz.2	-	9	1333	c.790T>A	c.(790-792)TAC>AAC	p.Y264N	SLC6A12_uc001qhx.2_5'UTR|SLC6A12_uc001qhy.2_5'UTR|SLC6A12_uc001qia.2_Missense_Mutation_p.Y264N|SLC6A12_uc001qib.2_Missense_Mutation_p.Y264N|SLC6A12_uc009zdh.1_Missense_Mutation_p.Y264N	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	264					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			ATGCCCTGGTAGGCTCCGGGA	0.562000													63	56					0	0	0.048971	0	0
KDM5A	5927	broad.mit.edu	37	12	401948	401948	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:401948A>G	uc001qif.1	-	27	5206	c.4843T>C	c.(4843-4845)TGC>CGC	p.C1615R	KDM5A_uc001qie.1_Missense_Mutation_p.C1620R	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1615	PHD-type 3.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						GGCCTTTGGCAGTTCTGTGCT	0.468000			T 	NUP98	AML								43	90					0	0	0.042209	0	0
C12orf5	57103	broad.mit.edu	37	12	4461705	4461705	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:4461705C>G	uc001qmp.2	+	6	740	c.661C>G	c.(661-663)CTG>GTG	p.L221V		NM_020375	NP_065108	Q9NQ88	TIGAR_HUMAN	TP53-induced glycolysis and apoptosis regulator	221						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			skin(1)	1			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			ACCAGCCACTCTGAGCAGATC	0.423000													46	55					0	0	0.045515	0	0
GPR162	27239	broad.mit.edu	37	12	6933600	6933600	+	Missense_Mutation	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:6933600T>C	uc001qqw.1	+	2	1071	c.536T>C	c.(535-537)TTT>TCT	p.F179S	GPR162_uc010sfn.1_Missense_Mutation_p.F179S|GPR162_uc001qqx.1_Intron|GPR162_uc009zfd.1_Intron|GPR162_uc001qqy.1_5'Flank	NM_019858	NP_062832	Q16538	GP162_HUMAN	G protein-coupled receptor 162 isoform 2	179	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCCTCGGCTTTGGCGTTTGC	0.597000													33	53					0	0	0.064281	0	0
DDX12	440081	broad.mit.edu	37	12	9573224	9573224	+	Missense_Mutation	SNP	C	T	T	rs7358609	by1000genomes	TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:9573224C>T	uc010sgs.1	-	21	2284	c.2089G>A	c.(2089-2091)GGT>AGT	p.G697S	DDX12_uc001qvx.3_5'Flank|DDX12_uc001qvy.1_5'Flank	NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						GAAACCACACCGCACAGGTTA	0.483000													4	66					0	0	0.014758	0	0
ITPR2	3709	broad.mit.edu	37	12	26809443	26809443	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:26809443C>G	uc001rhg.2	-	19	2648	c.2231G>C	c.(2230-2232)CGC>CCC	p.R744P		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	744	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CAGATACTGGCGATCCAAGCA	0.453000													25	53					0	0	0.021523	0	0
DIP2B	57609	broad.mit.edu	37	12	51092173	51092173	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:51092173A>G	uc001rwv.2	+	18	2267	c.2111A>G	c.(2110-2112)TAT>TGT	p.Y704C	DIP2B_uc009zlt.2_Missense_Mutation_p.Y134C	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	704						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GGATTGAGCTATGGGGTAATA	0.463000													36	62					0	0	0.064281	0	0
ESPL1	9700	broad.mit.edu	37	12	53680427	53680427	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:53680427C>A	uc001sck.2	+	18	3998	c.3907C>A	c.(3907-3909)CCT>ACT	p.P1303T	ESPL1_uc001scj.2_Missense_Mutation_p.P978T|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1303					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						AAAAAGTGTCCCTGGCTCAGA	0.527000													33	33					9.65963e-10	1.00655e-09	0.059317	1	0
RDH5	5959	broad.mit.edu	37	12	56115258	56115258	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:56115258A>G	uc001shk.2	+	2	473	c.290A>G	c.(289-291)GAG>GGG	p.E97G	BLOC1S1_uc001shj.3_Intron|RDH5_uc010spt.1_Missense_Mutation_p.E97G|RDH5_uc010spu.1_5'UTR|RDH5_uc001shl.2_Missense_Mutation_p.E97G	NM_002905	NP_002896	Q92781	RDH1_HUMAN	retinol dehydrogenase 5 (11-cis and 9-cis)	97					response to stimulus|visual perception	membrane	binding|retinol dehydrogenase activity			ovary(1)	1					NADH(DB00157)|Vitamin A(DB00162)	AAGTGGGTGGAGATGCACGTT	0.612000													34	53					0	0	0.069456	0	0
GLIPR1L2	144321	broad.mit.edu	37	12	75785104	75785104	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:75785104C>A	uc001sxr.1	+	1	216	c.208C>A	c.(208-210)CCC>ACC	p.P70T	CAPS2_uc001sxm.3_5'Flank|CAPS2_uc009zsa.2_5'Flank|GLIPR1L2_uc001sxp.1_Missense_Mutation_p.P70T|GLIPR1L2_uc001sxq.1_5'UTR	NM_152436	NP_689649	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	70						integral to membrane				ovary(1)	1						CGACGTCATTCCCCGAGGGTC	0.567000											OREG0021999	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	34					8.73648e-17	9.50284e-17	0.069456	1	0
NCOR2	9612	broad.mit.edu	37	12	124887099	124887099	+	Silent	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr12:124887099T>C	uc010tba.1	-	14	1608	c.1491A>G	c.(1489-1491)CAA>CAG	p.Q497Q	NCOR2_uc010tay.1_Silent_p.Q497Q|NCOR2_uc010taz.1_Silent_p.Q497Q|NCOR2_uc010tbb.1_Silent_p.Q497Q|NCOR2_uc010tbc.1_Silent_p.Q496Q|NCOR2_uc001ugj.1_Silent_p.Q497Q	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	497	Poly-Gln.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		gctgctgttgttgctgctgct	0.353000													3	3					0	0	0.004672	0	0
CUL4A	8451	broad.mit.edu	37	13	113915023	113915023	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr13:113915023C>G	uc010tjy.1	+	20	2145	c.2134C>G	c.(2134-2136)CAT>GAT	p.H712D	CUL4A_uc010tjx.1_Missense_Mutation_p.H612D|CUL4A_uc010agu.2_Missense_Mutation_p.H573D|CUL4A_uc010tjz.1_Missense_Mutation_p.H391D	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	712					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			GACTCTTGGTCATAATCTTCT	0.328000													13	16					0	0	0.013537	0	0
LAMP1	3916	broad.mit.edu	37	13	113963979	113963979	+	Missense_Mutation	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr13:113963979T>C	uc001vtm.1	+	3	486	c.205T>C	c.(205-207)TCA>CCA	p.S69P	LAMP1_uc010tka.1_Missense_Mutation_p.S69P	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	69	Lumenal (Potential).|First lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			TGACCTGCCATCAGATGCCAC	0.423000													40	65					0	0	0.025465	0	0
SDCCAG1	9147	broad.mit.edu	37	14	50292672	50292672	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr14:50292672G>A	uc001wxc.2	-	16	1558	c.1490C>T	c.(1489-1491)GCA>GTA	p.A497V	SDCCAG1_uc010anj.1_Missense_Mutation_p.A497V|SDCCAG1_uc010tqi.1_Missense_Mutation_p.A497V|SDCCAG1_uc001wxe.2_Missense_Mutation_p.A455V|SDCCAG1_uc001wxd.1_5'UTR|SDCCAG1_uc010anq.1_Missense_Mutation_p.A268V	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	497						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		TGACTTGAATGCCTATTTATA	0.269000													15	5					0	0	0.028581	0	0
MYO5A	4644	broad.mit.edu	37	15	52606371	52606371	+	Silent	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr15:52606371T>C	uc002aby.2	-	40	5608	c.5364A>G	c.(5362-5364)CCA>CCG	p.P1788P	MYO5A_uc002abx.3_Silent_p.P1761P|MYO5A_uc010ugd.1_Silent_p.P510P	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1788	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		ACTCATTAACTGGAGTATACA	0.348000													26	45					0	0	0.024334	0	0
SRRM2	23524	broad.mit.edu	37	16	2812806	2812806	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr16:2812806C>G	uc002crk.2	+	11	2826	c.2277C>G	c.(2275-2277)AGC>AGG	p.S759R	SRRM2_uc002crj.1_Missense_Mutation_p.S663R|SRRM2_uc002crl.1_Missense_Mutation_p.S759R|SRRM2_uc010bsu.1_Missense_Mutation_p.S663R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	759	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CAAGGCGGAGCAGGTCTCTCT	0.473000													156	109					0	0	0.048971	0	0
PRKCB	5579	broad.mit.edu	37	16	23848699	23848699	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr16:23848699C>T	uc002dmd.2	+	2	374	c.177C>T	c.(175-177)GGC>GGT	p.G59G	PRKCB_uc002dme.2_Silent_p.G59G	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	59	Phorbol-ester/DAG-type 1.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TTTGCAGGGGCTTCGGGAAGC	0.552000													176	118					0	0	0.048971	0	0
ZNF48	197407	broad.mit.edu	37	16	30408740	30408740	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr16:30408740G>C	uc002dya.1	+	2	228	c.169G>C	c.(169-171)GCT>CCT	p.A57P	ZNF48_uc002dxz.1_5'UTR	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGAAGATTTGGCTCCAGATCA	0.488000													41	138					0	0	0.030466	0	0
ZC3H18	124245	broad.mit.edu	37	16	88653085	88653085	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr16:88653085C>T	uc002fky.2	+	3	881	c.681C>T	c.(679-681)TTC>TTT	p.F227F	ZC3H18_uc010voy.1_Silent_p.F110F|ZC3H18_uc010voz.1_Silent_p.F227F|ZC3H18_uc010vpa.1_Silent_p.F227F	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	227	C3H1-type.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		GCCGGTTCTTCATGAAAGGTA	0.587000													17	48					0	0	0.033300	0	0
SAT2	112483	broad.mit.edu	37	17	7530935	7530935	+	Nonsense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr17:7530935G>A	uc002gic.2	-	1	260	c.19C>T	c.(19-21)CGA>TGA	p.R7*	SHBG_uc010cmo.2_Intron|SHBG_uc010cmp.2_Intron|SHBG_uc010cmq.2_Intron|SHBG_uc010cmr.2_Intron|SHBG_uc010cms.2_Intron|SHBG_uc010cmt.2_Intron|SHBG_uc010cmu.2_Intron|SAT2_uc002gib.1_RNA|SHBG_uc010cmz.2_5'Flank|SHBG_uc010cmv.2_5'Flank|SHBG_uc010cmw.2_5'Flank|SHBG_uc010cmx.2_5'Flank|SHBG_uc010cmy.2_5'Flank|SHBG_uc002gid.3_5'Flank|SHBG_uc002gie.2_5'Flank|SHBG_uc010cnd.2_5'Flank|SHBG_uc010cna.2_5'Flank|SHBG_uc010vue.1_5'Flank|SHBG_uc010vuf.1_5'Flank|SHBG_uc010cnb.2_5'Flank|SHBG_uc010cnc.2_5'Flank	NM_133491	NP_597998	Q96F10	SAT2_HUMAN	diamine N-acetyltransferase 2	7	N-acetyltransferase.					cytoplasm	diamine N-acetyltransferase activity	p.?(1)			0				READ - Rectum adenocarcinoma(115;0.166)	Spermine(DB00127)	TTGGCCTCTCGGATCCGCACG	0.632000													15	33					0	0	0.033300	0	0
TOP3A	7156	broad.mit.edu	37	17	18181411	18181411	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr17:18181411G>A	uc002gsx.1	-	18	2634	c.2405C>T	c.(2404-2406)CCC>CTC	p.P802L	TOP3A_uc010cpz.1_Missense_Mutation_p.P254L|TOP3A_uc010vxr.1_Missense_Mutation_p.P332L|TOP3A_uc002gsw.1_Missense_Mutation_p.P254L|TOP3A_uc010vxs.1_Missense_Mutation_p.P700L	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	802					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						AGCAGCCGTGGGTGGTGGGAG	0.627000													41	65					0	0	0.025465	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	T	T	rs76270529	by1000genomes	TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr17:39254054A>T	uc010wfo.1	-	1	322	c.283T>A	c.(283-285)TGC>AGC	p.C95S		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].|15.					keratin filament					0						ctggagatgcagcagcTAGGG	0.318000													8	55					0	0	0.069234	0	0
MRO	83876	broad.mit.edu	37	18	48331527	48331527	+	Silent	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr18:48331527A>G	uc002lew.3	-	5	720	c.426T>C	c.(424-426)GAT>GAC	p.D142D	MRO_uc010xdn.1_Silent_p.D142D|MRO_uc010dpa.2_Silent_p.D156D|MRO_uc010dpb.2_Silent_p.D156D|MRO_uc010dpc.2_Silent_p.D142D|MRO_uc002lex.3_Silent_p.D142D	NM_031939	NP_114145	Q9BYG7	MSTRO_HUMAN	maestro isoform a	142	HEAT.					nucleolus	binding				0		Colorectal(6;0.0596)		Colorectal(21;0.082)		TACTTACGTCATCTAATAAAG	0.338000													9	48					0	0	0.034045	0	0
LINGO3	645191	broad.mit.edu	37	19	2290213	2290213	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr19:2290213C>T	uc010dsx.1	-	2	1691	c.1563G>A	c.(1561-1563)CCG>CCA	p.P521P	SPPL2B_uc010dsw.1_Intron|uc002lvo.1_5'UTR	NM_001101391	NP_001094861	P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	521	Extracellular (Potential).					integral to membrane					0						TGAGGTCGAGCGGCGCGCGCA	0.706000													18	30					0	0	0.062417	0	0
ZNF557	79230	broad.mit.edu	37	19	7075688	7075688	+	Silent	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr19:7075688C>G	uc002mgb.2	+	4	518	c.33C>G	c.(31-33)GCC>GCG	p.A11A	ZNF557_uc002mga.2_Silent_p.A18A|ZNF557_uc002mgc.2_Silent_p.A18A	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		TGTTCCCAGCCTCTCAGCGAG	0.532000													41	52					0	0	0.048971	0	0
CACNA1A	773	broad.mit.edu	37	19	13346025	13346025	+	Nonsense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr19:13346025G>A	uc010dze.2	-	33	5370	c.5134C>T	c.(5134-5136)CAG>TAG	p.Q1712*	CACNA1A_uc010xnd.1_Nonsense_Mutation_p.Q417*|CACNA1A_uc002mwx.3_Nonsense_Mutation_p.Q417*|CACNA1A_uc010dzc.2_Nonsense_Mutation_p.Q1237*|CACNA1A_uc002mwy.3_Nonsense_Mutation_p.Q1711*|CACNA1A_uc002mwv.3_Nonsense_Mutation_p.Q228*	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1712	Extracellular (Potential).|IV.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACACTCACCTGCATCCCAATG	0.557000											OREG0025293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	10					0	0	0.014758	0	0
ZNF461	92283	broad.mit.edu	37	19	37147417	37147417	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr19:37147417G>C	uc002oem.2	-	4	393	c.165C>G	c.(163-165)ATC>ATG	p.I55M	ZNF461_uc002oen.2_Missense_Mutation_p.I24M|ZNF461_uc010xtj.1_Missense_Mutation_p.I55M	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CCAATGAGGAGATTACGGCTG	0.443000													30	36					0	0	0.037714	0	0
RYR1	6261	broad.mit.edu	37	19	39058443	39058443	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr19:39058443C>T	uc002oit.2	+	93	13675	c.13545C>T	c.(13543-13545)CCC>CCT	p.P4515P	RYR1_uc002oiu.2_Silent_p.P4510P	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4515	Pro-rich.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AAGAAGTTCCCGAGCCCACAC	0.557000													20	51					0	0	0.062417	0	0
ERCC2	2068	broad.mit.edu	37	19	45868315	45868315	+	Silent	SNP	G	A	A	rs139263710		TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr19:45868315G>A	uc002pbj.2	-	6	509	c.462C>T	c.(460-462)CAC>CAT	p.H154H	ERCC2_uc010ejz.2_Intron|ERCC2_uc002pbk.2_Silent_p.H130H|ERCC2_uc002pbl.3_Silent_p.H130H|ERCC2_uc010xxj.1_Intron	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	154	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		AGAATCGGCAGTGGGGCAGGC	0.637000			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				20	24					0	0	0.062417	0	0
ZNF321	399669	broad.mit.edu	37	19	53432286	53432286	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr19:53432286A>G	uc010eqj.2	-	4	694	c.524T>C	c.(523-525)TTG>TCG	p.L175S	ZNF321_uc002qaj.1_Missense_Mutation_p.L122S|ZNF321_uc002qak.1_Missense_Mutation_p.L175S	NM_203307	NP_976052			zinc finger protein 321												0				GBM - Glioblastoma multiforme(134;0.0305)		TTGGGATGTCAAAATTAAGGA	0.373000													82	98					0	0	0.048971	0	0
NLRP9	338321	broad.mit.edu	37	19	56244868	56244868	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr19:56244868A>T	uc002qly.2	-	2	357	c.329T>A	c.(328-330)ATA>AAA	p.I110K		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	110						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CTTCTCCCATATGAGTTGAAA	0.363000													44	58					0	0	0.048971	0	0
MZF1	7593	broad.mit.edu	37	19	59073766	59073766	+	Missense_Mutation	SNP	G	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr19:59073766G>T	uc002qto.2	-	6	2439	c.1878C>A	c.(1876-1878)CAC>CAA	p.H626Q	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Missense_Mutation_p.H626Q	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	626	C2H2-type 10.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		ACTCACCGCAGTGGTAGGGCT	0.682000													10	5					0.000673444	0.000684484	0.069234	1	0
MYADML	151325	broad.mit.edu	37	2	33952621	33952621	+	Silent	SNP	G	A	A	rs11684598	by1000genomes	TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr2:33952621G>A	uc002rpb.2	-	1	664	c.222C>T	c.(220-222)TAC>TAT	p.Y74Y		NR_003143				RecName: Full=Myeloid-associated differentiation marker-like protein.;												0						CTTCGGTGGCGTAAGCCACAC	0.647000													3	26					0	0	0.004672	0	0
PSME4	23198	broad.mit.edu	37	2	54176408	54176408	+	Silent	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr2:54176408A>G	uc002rxp.2	-	2	311	c.255T>C	c.(253-255)CTT>CTC	p.L85L	PSME4_uc010yop.1_5'UTR|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_5'UTR	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	85					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TTCTCCCATAAAGTCGAatat	0.179000													9	23					0	0	0.047766	0	0
CHRNA1	1134	broad.mit.edu	37	2	175624262	175624262	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr2:175624262A>T	uc002ujd.2	-	2	221	c.143T>A	c.(142-144)GTC>GAC	p.V48D	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Missense_Mutation_p.V48D|CHRNA1_uc002ujf.3_Missense_Mutation_p.V48D	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	48	Extracellular.				muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GACCTCCACGACCTGGCGGTG	0.617000													77	150					0	0	0.048971	0	0
SLC40A1	30061	broad.mit.edu	37	2	190428363	190428363	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr2:190428363A>T	uc002uqp.3	-	7	1700	c.1349T>A	c.(1348-1350)GTG>GAG	p.V450E		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	450	Helical; (Potential).				anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			GATTATGGGCACAGATTCAGG	0.368000													37	48					0	0	0.069456	0	0
HECW2	57520	broad.mit.edu	37	2	197187250	197187250	+	Missense_Mutation	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr2:197187250C>T	uc002utm.1	-	7	1019	c.836G>A	c.(835-837)GGG>GAG	p.G279E	HECW2_uc002utl.1_5'UTR	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	279	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GGTTAGTTTCCCCAGAAAACG	0.413000													67	96					0	0	0.048971	0	0
ABCB6	10058	broad.mit.edu	37	2	220075814	220075814	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr2:220075814A>G	uc002vkc.1	-	15	2262	c.1985T>C	c.(1984-1986)CTC>CCC	p.L662P	ABCB6_uc010fwe.1_Missense_Mutation_p.L616P	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	662	ABC transporter.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGAGACCGGAGAGAGGCCTG	0.468000													43	69					0	0	0.048971	0	0
CPXM1	56265	broad.mit.edu	37	20	2776796	2776796	+	Silent	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr20:2776796C>G	uc002wgu.2	-	10	1318	c.1254G>C	c.(1252-1254)CTG>CTC	p.L418L	CPXM1_uc010gas.2_Silent_p.L418L	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	418					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						CCCAGCCCACCAGCTCTGAAC	0.602000													29	49					0	0	0.027356	0	0
TPTE	7179	broad.mit.edu	37	21	11014987	11014987	+	RNA	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr21:11014987A>G	uc002yis.1	-	7		c.1459T>C						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTATAGTTTCAATAGCAGACT	0.388000													3	31					0	0	0.004672	0	0
HUNK	30811	broad.mit.edu	37	21	33371363	33371363	+	Missense_Mutation	SNP	A	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr21:33371363A>C	uc002yph.2	+	11	2371	c.2011A>C	c.(2011-2013)ATG>CTG	p.M671L		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	671					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						CATCGGACAGATGTTAAGGAA	0.617000													36	67					0	0	0.054565	0	0
MICAL3	57553	broad.mit.edu	37	22	18293513	18293513	+	Missense_Mutation	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr22:18293513T>C	uc002zng.3	-	28	5865	c.5512A>G	c.(5512-5514)AGA>GGA	p.R1838G	MICAL3_uc011agl.1_Missense_Mutation_p.R1754G|MICAL3_uc010gre.1_RNA	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1838	Potential.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		TTGGCCTGTCTCCGAGCTGCC	0.572000													22	40					0	0	0.076483	0	0
MTMR3	8897	broad.mit.edu	37	22	30413918	30413918	+	Silent	SNP	G	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr22:30413918G>T	uc003agv.3	+	16	2005	c.1677G>T	c.(1675-1677)GTG>GTT	p.V559V	MTMR3_uc003agu.3_Silent_p.V559V|MTMR3_uc003agw.3_Silent_p.V559V	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	559	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			CTCCTCAGGTGCTGTACCCTG	0.552000													50	99					2.55665e-31	2.85607e-31	0.048971	1	0
POLR2F	5435	broad.mit.edu	37	22	38355418	38355418	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr22:38355418C>G	uc003aul.2	+	3	277	c.156C>G	c.(154-156)ATC>ATG	p.I52M	POLR2F_uc010gxi.2_Missense_Mutation_p.H46D|POLR2F_uc003aum.2_RNA	NM_021974	NP_068809	P61218	RPAB2_HUMAN	DNA directed RNA polymerase II polypeptide F	52					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)	1	Melanoma(58;0.045)					AGAAGCGAATCACCACACCAT	0.577000													92	123					0	0	0.048971	0	0
KDELR3	11015	broad.mit.edu	37	22	38875733	38875733	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr22:38875733A>G	uc003avv.2	+	3	484	c.328A>G	c.(328-330)AAC>GAC	p.N110D	KDELR3_uc003avu.2_Missense_Mutation_p.N110D	NM_006855	NP_006846	O43731	ERD23_HUMAN	KDEL receptor 3 isoform a	110	Helical; (Potential).				protein retention in ER lumen|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	ER retention sequence binding|receptor activity			ovary(2)	2	Melanoma(58;0.0286)					CTTCCTTGAAAACTACAGTTT	0.473000													146	182					0	0	0.048971	0	0
SEC13	6396	broad.mit.edu	37	3	10342967	10342967	+	Missense_Mutation	SNP	T	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr3:10342967T>C	uc003bvn.2	-	9	1066	c.947A>G	c.(946-948)GAG>GGG	p.E316G	SEC13_uc003bvl.2_Missense_Mutation_p.E248G|SEC13_uc003bvm.2_Missense_Mutation_p.E302G|SEC13_uc003bvp.2_Missense_Mutation_p.E319G|SEC13_uc003bvo.2_Missense_Mutation_p.E362G|SEC13_uc003bvq.1_Intron	NM_183352	NP_899195	P55735	SEC13_HUMAN	SEC13 protein isoform 1	316					COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			ovary(1)	1						CTGCTGGCCCTCTGTCACTGA	0.612000													33	50					0	0	0.054565	0	0
MLH1	4292	broad.mit.edu	37	3	37042512	37042512	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr3:37042512G>A	uc003cgl.2	+	3	334	c.274G>A	c.(274-276)GCC>ACC	p.A92T	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Missense_Mutation_p.A92T|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_5'UTR|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	92					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TGAGGATTTAGCCAGTATTTC	0.348000		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				34	32					0	0	0.023175	0	0
XYLB	9942	broad.mit.edu	37	3	38404484	38404484	+	Silent	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr3:38404484C>G	uc003cic.2	+	4	376	c.267C>G	c.(265-267)GTC>GTG	p.V89V	XYLB_uc011ayp.1_Intron|XYLB_uc003cid.1_Silent_p.V11V	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	89					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TCTCTCAAGTCCTAGCCTTGT	0.532000													39	55					0	0	0.033182	0	0
ZNF717	100131827	broad.mit.edu	37	3	75790798	75790798	+	Silent	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr3:75790798G>A	uc011bgi.1	-	3	470	c.147C>T	c.(145-147)GAC>GAT	p.D49D	ZNF717_uc003dpw.3_RNA	NM_001128223	NP_001121695	C9JSV9	C9JSV9_HUMAN	zinc finger protein 717	49					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						CCAGCATCACGTCCCTGTACA	0.502000													4	9					0	0	0.038147	0	0
ABHD10	55347	broad.mit.edu	37	3	111700691	111700691	+	Missense_Mutation	SNP	A	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr3:111700691A>G	uc003dyk.3	+	2	284	c.203A>G	c.(202-204)TAT>TGT	p.Y68C	ABHD10_uc011bhq.1_Intron	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	68						mitochondrion	serine-type peptidase activity				0						AACCTGGCTTATAAGAAGCTA	0.378000													53	68					0	0	0.048971	0	0
EEFSEC	60678	broad.mit.edu	37	3	127981023	127981023	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr3:127981023G>C	uc003eki.2	+	3	615	c.577G>C	c.(577-579)GCC>CCC	p.A193P	EEFSEC_uc003ekj.2_Missense_Mutation_p.A193P	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	193						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GGGACCAGAGGCCCCCGAAAC	0.562000													68	82					0	0	0.048971	0	0
ZMAT3	64393	broad.mit.edu	37	3	178785387	178785387	+	Nonsense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr3:178785387C>A	uc003fjg.2	-	2	413	c.154G>T	c.(154-156)GAG>TAG	p.E52*	ZMAT3_uc010hxa.2_Nonsense_Mutation_p.E52*|ZMAT3_uc003fji.2_Nonsense_Mutation_p.E52*	NM_022470	NP_071915	Q9HA38	ZMAT3_HUMAN	p53 target zinc finger protein isoform 1	52					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			ovary(2)	2	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			TTCGATAACTCTTCTTCCCCT	0.552000													41	72					2.26627e-22	2.48688e-22	0.030466	1	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr3:195505836G>C	uc011bto.1	-	3	12691	c.12231C>G	c.(12229-12231)CAC>CAG	p.H4077Q	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													3	1					0	0	0.004672	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1324927	1324927	+	Missense_Mutation	SNP	A	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr5:1324927A>T	uc003jch.2	-	11	1194	c.1148T>A	c.(1147-1149)TTT>TAT	p.F383Y	CLPTM1L_uc003jcg.2_Missense_Mutation_p.F214Y	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like	383	Cytoplasmic (Potential).				apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		GTAAGTGCCAAACTGTTGTGA	0.488000													37	44					0	0	0.074837	0	0
RGNEF	64283	broad.mit.edu	37	5	73205322	73205322	+	Missense_Mutation	SNP	T	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr5:73205322T>A	uc011csq.1	+	33	4258	c.4247T>A	c.(4246-4248)ATC>AAC	p.I1416N	RGNEF_uc003kcx.2_Missense_Mutation_p.I1416N|RGNEF_uc010izf.2_Missense_Mutation_p.I1416N|RGNEF_uc011csr.1_Missense_Mutation_p.I1103N|RGNEF_uc003kcz.3_Missense_Mutation_p.I380N|RGNEF_uc003kda.3_Missense_Mutation_p.I336N	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	1416					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		GGCCACTCTATCCTCCGAGGC	0.622000													9	10					0	0	0.058154	0	0
SEMA6A	57556	broad.mit.edu	37	5	115822558	115822558	+	Silent	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr5:115822558G>A	uc010jck.2	-	10	1558	c.849C>T	c.(847-849)TGC>TGT	p.C283C	SEMA6A_uc003krx.3_Silent_p.C283C	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	283	Sema.|Extracellular (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CAGGAACTGAGCAGTTCAAGC	0.463000													50	70					0	0	0.048971	0	0
LOC153328	153328	broad.mit.edu	37	5	135178132	135178132	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr5:135178132C>A	uc003laz.1	+	2	246	c.74C>A	c.(73-75)CCT>CAT	p.P25H	LOC153328_uc003lba.2_Missense_Mutation_p.P25H			Q6ZT89	S2548_HUMAN	RecName: Full=Putative mitochondrial carrier protein FLJ44862;	25	Helical; Name=1; (Potential).|Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTGGCCACCCTCTGGACACA	0.507000													58	106					8.27209e-15	8.91948e-15	0.048971	1	0
LOC153328	153328	broad.mit.edu	37	5	135207543	135207543	+	Missense_Mutation	SNP	G	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr5:135207543G>T	uc003laz.1	+	5	987	c.815G>T	c.(814-816)GGT>GTT	p.G272V	LOC153328_uc003lba.2_Intron			Q6ZT89	S2548_HUMAN	RecName: Full=Putative mitochondrial carrier protein FLJ44862;	Error:Variant_position_missing_in_Q6ZT89_after_alignment					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCTTTGTTAGGTACCTACTCT	0.542000													27	29					2.12542e-12	2.23349e-12	0.030593	1	0
RANBP17	64901	broad.mit.edu	37	5	170323085	170323085	+	Missense_Mutation	SNP	T	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr5:170323085T>A	uc003mba.2	+	5	471	c.455T>A	c.(454-456)ATA>AAA	p.I152K	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_Intron|RANBP17_uc003maw.2_Missense_Mutation_p.I152K|RANBP17_uc011dew.1_Missense_Mutation_p.I152K	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	152					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATAGGAGTAATAATCCTTTCT	0.388000			T	TRD@	ALL								40	52					0	0	0.027894	0	0
SLC17A4	10050	broad.mit.edu	37	6	25773825	25773825	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr6:25773825G>A	uc003nfe.2	+	8	1029	c.910G>A	c.(910-912)GAA>AAA	p.E304K	SLC17A4_uc011djx.1_Intron|SLC17A4_uc003nff.1_Missense_Mutation_p.E65K|SLC17A4_uc003nfg.2_Missense_Mutation_p.E241K|SLC17A4_uc010jqa.2_Missense_Mutation_p.E17K	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	304	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						TTATTTCTGTGAATACTGGCT	0.443000													34	55					0	0	0.054565	0	0
MUC21	394263	broad.mit.edu	37	6	30955264	30955264	+	Missense_Mutation	SNP	T	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr6:30955264T>A	uc003nsh.2	+	2	1563	c.1312T>A	c.(1312-1314)TCT>ACT	p.S438T	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	438	Ser-rich.|28.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						AGCCACCAACTCTGGGTCCAG	0.577000													71	96					0	0	0.048971	0	0
MCM3	4172	broad.mit.edu	37	6	52141973	52141973	+	Missense_Mutation	SNP	G	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr6:52141973G>C	uc003pan.1	-	8	1167	c.1057C>G	c.(1057-1059)CAG>GAG	p.Q353E	MCM3_uc011dwu.1_Missense_Mutation_p.Q307E	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	353	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					CGCAGAAGCTGAGACTTGGCA	0.597000													12	25					0	0	0.010729	0	0
KIAA1549	57670	broad.mit.edu	37	7	138597164	138597164	+	Missense_Mutation	SNP	A	C	C			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr7:138597164A>C	uc011kql.1	-	3	2970	c.2921T>G	c.(2920-2922)ATC>AGC	p.I974S	KIAA1549_uc003vuk.3_Missense_Mutation_p.I924S|KIAA1549_uc011kqj.1_Missense_Mutation_p.I974S	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	974						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TACTTCTTTGATTGCTGTAAT	0.463000			O	BRAF	pilocytic astrocytoma								35	22					0	0	0.050027	0	0
ATP6V0E2	155066	broad.mit.edu	37	7	149576654	149576654	+	Missense_Mutation	SNP	C	G	G			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr7:149576654C>G	uc003wgr.2	+	4	1550	c.599C>G	c.(598-600)CCG>CGG	p.P200R	ATP6V0E2_uc003wgs.2_Missense_Mutation_p.P177R|ATP6V0E2_uc003wgp.2_3'UTR|ATP6V0E2_uc003wgq.2_RNA|uc003wgt.1_5'Flank	NM_145230	NP_660265	Q8NHE4	VA0E2_HUMAN	ATPase, H+ transporting, V0 subunit isoform 1	Error:Variant_position_missing_in_Q8NHE4_after_alignment					ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuole	ATPase activity, coupled to transmembrane movement of ions|hydrogen ion transmembrane transporter activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00256)			CTCCAATACCCGCACTGCTCT	0.637000													17	7					0	0	0.038395	0	0
LYN	4067	broad.mit.edu	37	8	56922610	56922610	+	Missense_Mutation	SNP	C	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr8:56922610C>A	uc003xsk.3	+	13	1762	c.1480C>A	c.(1480-1482)CAG>AAG	p.Q494K	LYN_uc003xsl.3_Missense_Mutation_p.Q473K	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	494	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			TGACTACTTACAGAGCGTCCT	0.527000													34	60					8.4185e-14	8.99909e-14	0.050027	1	0
GEM	2669	broad.mit.edu	37	8	95262646	95262646	+	Silent	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr8:95262646G>A	uc003ygj.2	-	5	1032	c.783C>T	c.(781-783)AGC>AGT	p.S261S	GEM_uc003ygi.2_Silent_p.S261S	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	261					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			TCCTGGGCATGCTCTCCTTCC	0.552000													22	40					0	0	0.062417	0	0
OR13J1	392309	broad.mit.edu	37	9	35869823	35869823	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr9:35869823C>T	uc011lph.1	-	1	576	c.576G>A	c.(574-576)ACG>ACA	p.T192T		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			CGCTGACCGACGTGTTGCCGC	0.597000													16	34					0	0	0.024245	0	0
SECISBP2	79048	broad.mit.edu	37	9	91965762	91965762	+	Missense_Mutation	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr9:91965762C>T	uc004aqj.1	+	14	2188	c.2108C>T	c.(2107-2109)TCA>TTA	p.S703L	SECISBP2_uc011ltk.1_Missense_Mutation_p.S702L|SECISBP2_uc004aqk.1_Missense_Mutation_p.S630L|SECISBP2_uc010mqo.1_Missense_Mutation_p.S408L|SECISBP2_uc011ltl.1_Missense_Mutation_p.S635L	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	703					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						AAGATACAGTCAAAAGGTAAA	0.498000													30	32					0	0	0.034045	0	0
RAD23B	5887	broad.mit.edu	37	9	110091836	110091836	+	Missense_Mutation	SNP	G	A	A			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr9:110091836G>A	uc004bde.2	+	10	1496	c.1129G>A	c.(1129-1131)GGA>AGA	p.G377R	RAD23B_uc011lwb.1_Missense_Mutation_p.G356R	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	377	UBA 2.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						AAAGGCATTAGGATTTCCTGA	0.328000								Direct_reversal_of_damage|NER					28	58					0	0	0.037714	0	0
RABGAP1	23637	broad.mit.edu	37	9	125751642	125751642	+	Silent	SNP	C	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr9:125751642C>T	uc011lzh.1	+	5	791	c.657C>T	c.(655-657)GTC>GTT	p.V219V	RABGAP1_uc004bnl.3_RNA|RABGAP1_uc004bnm.1_Silent_p.V219V	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	219	PID.				cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						TCTTCTGTGTCAGAGGGCATG	0.413000													41	43					0	0	0.027894	0	0
SLC30A1	7779	broad.mit.edu	37	1	211749303	211749308	+	In_Frame_Del	DEL	ATCTAA	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr1:211749303_211749308delATCTAA	uc001hio.1	-	2	1091_1096	c.946_951delTTAGAT	c.(946-951)TTAGATdel	p.LD316del		NM_021194	NP_067017	Q9Y6M5	ZNT1_HUMAN	solute carrier family 30 (zinc transporter),	316_317	Helical; (Potential).				cadmium ion transmembrane transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|negative regulation of calcium ion import|negative regulation of neurotransmitter secretion|negative regulation of zinc ion import	integral to membrane|T-tubule	calcium channel inhibitor activity|zinc ion transmembrane transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(81;0.00535)|GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.0604)|Epithelial(68;0.0978)		AAAGAGTTGGATCTAAATATAGCACC	0.364													72	23	---	---	---	---					
SIDT2	51092	broad.mit.edu	37	11	117058116	117058118	+	In_Frame_Del	DEL	TTC	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr11:117058116_117058118delTTC	uc001pqh.1	+	11	1079_1081	c.1038_1040delTTC	c.(1036-1041)GATTCT>GAT	p.S347del	SIDT2_uc010rxe.1_In_Frame_Del_p.S347del|SIDT2_uc001pqg.2_In_Frame_Del_p.S347del|SIDT2_uc001pqi.1_In_Frame_Del_p.S351del	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	347	Cytoplasmic (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		TCCTGGCTGATTCTTTTCCTGGC	0.517													58	97	---	---	---	---					
DLGAP5	9787	broad.mit.edu	37	14	55655750	55655751	+	Frame_Shift_Ins	INS	-	AT	AT			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr14:55655750_55655751insAT	uc001xbs.2	-	2	364_365	c.147_148insAT	c.(145-150)GATGTAfs	p.D49fs	DLGAP5_uc001xbt.2_Frame_Shift_Ins_p.D49fs	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	49_50					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						GGAATGTTTACATCTTTCAAAC	0.347													28	15	---	---	---	---					
DISP2	85455	broad.mit.edu	37	15	40661086	40661086	+	Frame_Shift_Del	DEL	A	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr15:40661086delA	uc001zlk.1	+	8	2862	c.2773delA	c.(2773-2775)AATfs	p.N925fs		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	925					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		GCTCTTCTACAATGAGGTCAG	0.602													40	60	---	---	---	---					
VPS24	51652	broad.mit.edu	37	2	86790455	86790455	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr2:86790455delT	uc002srj.2	-	1	146	c.17delA	c.(16-18)AAGfs	p.K6fs	VPS24_uc002srk.2_5'UTR|VPS24_uc002srl.2_Frame_Shift_Del_p.K6fs|VPS24_uc010ytl.1_Intron	NM_016079	NP_057163	Q9Y3E7	CHMP3_HUMAN	vacuolar protein sorting 24 isoform 1	6	Intramolecular interaction with C- terminus.				cell cycle|cell division|cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			central_nervous_system(1)	1						CTCCTGGGTCTTTCCAAACAG	0.632													93	127	---	---	---	---					
TTC3	7267	broad.mit.edu	37	21	38568034	38568035	+	Frame_Shift_Ins	INS	-	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr21:38568034_38568035insT	uc002yvz.2	+	42	5381_5382	c.5276_5277insT	c.(5275-5277)TCTfs	p.S1759fs	TTC3_uc002ywa.2_Frame_Shift_Ins_p.S1759fs|TTC3_uc002ywb.2_Frame_Shift_Ins_p.S1759fs|TTC3_uc010gnf.2_Frame_Shift_Ins_p.S1524fs|TTC3_uc002ywc.2_Frame_Shift_Ins_p.S1449fs	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1759					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				CTTGTGACTTCTGCAAGCGACG	0.569													129	176	---	---	---	---					
KIAA1109	84162	broad.mit.edu	37	4	123229112	123229112	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr4:123229112delT	uc003ieh.2	+	56	9895	c.9850delT	c.(9850-9852)TTTfs	p.F3284fs	KIAA1109_uc003iel.1_Frame_Shift_Del_p.F1219fs	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3284					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGCTGTGCTGTTTTGGCTGAA	0.343													65	108	---	---	---	---					
HSPA9	3313	broad.mit.edu	37	5	137904733	137904733	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr5:137904733delT	uc003ldf.2	-	5	524	c.416delA	c.(415-417)AATfs	p.N139fs	HSPA9_uc011cyw.1_Frame_Shift_Del_p.N70fs	NM_004134	NP_004125	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 precursor	139					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AAAGGGAACATTTTTACTGTA	0.403													40	63	---	---	---	---					
COL19A1	1310	broad.mit.edu	37	6	70866589	70866589	+	Frame_Shift_Del	DEL	G	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr6:70866589delG	uc003pfc.1	+	34	2383	c.2266delG	c.(2266-2268)GGGfs	p.G756fs	COL19A1_uc010kam.1_Frame_Shift_Del_p.G652fs	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	756	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGGCTACCCTGGGATACCTGG	0.378													7	14	---	---	---	---					
FERD3L	222894	broad.mit.edu	37	7	19184646	19184646	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr7:19184646delT	uc003suo.1	-	1	399	c.340delA	c.(340-342)ATGfs	p.M114fs	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	114	Helix-loop-helix motif.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						AGGTTGAACATCCGCTTCCTT	0.557													26	54	---	---	---	---					
SEMA3D	223117	broad.mit.edu	37	7	84636164	84636164	+	Frame_Shift_Del	DEL	G	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr7:84636164delG	uc003uic.2	-	16	1902	c.1862delC	c.(1861-1863)ACTfs	p.T621fs	SEMA3D_uc010led.2_Frame_Shift_Del_p.T621fs|SEMA3D_uc003uib.2_Frame_Shift_Del_p.T260fs	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	621	Ig-like C2-type.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CCATTTAATAGTTGCTTGTTG	0.388													305	136	---	---	---	---					
NEIL2	252969	broad.mit.edu	37	8	11637150	11637150	+	Frame_Shift_Del	DEL	A	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr8:11637150delA	uc003wug.2	+	3	857	c.182delA	c.(181-183)GAAfs	p.E61fs	NEIL2_uc003wue.2_Frame_Shift_Del_p.E61fs|NEIL2_uc003wuf.2_5'UTR|NEIL2_uc011kxd.1_Intron	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	61					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		CTAGATGAAGAAATGGGGCCC	0.527								BER_DNA_glycosylases					91	99	---	---	---	---					
RAD54B	25788	broad.mit.edu	37	8	95419720	95419720	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	c4639d70-5aff-4a23-b1bd-33ce71bff272	g.chr8:95419720delT	uc003ygk.2	-	5	826	c.728delA	c.(727-729)AATfs	p.N243fs	RAD54B_uc010may.1_Frame_Shift_Del_p.N50fs|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			ATTCTGTCTATTTTCCTTTGA	0.353								Direct_reversal_of_damage|Homologous_recombination					58	59	---	---	---	---					
SLC30A1	7779	broad.mit.edu	37	1	211749303	211749308	+	In_Frame_Del	DEL	ATCTAA	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr1:211749303_211749308delATCTAA	uc001hio.1	-	2	1091_1096	c.946_951delTTAGAT	c.(946-951)TTAGATdel	p.LD316del		NM_021194	NP_067017	Q9Y6M5	ZNT1_HUMAN	solute carrier family 30 (zinc transporter),	316_317	Helical; (Potential).				cadmium ion transmembrane transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|negative regulation of calcium ion import|negative regulation of neurotransmitter secretion|negative regulation of zinc ion import	integral to membrane|T-tubule	calcium channel inhibitor activity|zinc ion transmembrane transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(81;0.00535)|GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.0604)|Epithelial(68;0.0978)		AAAGAGTTGGATCTAAATATAGCACC	0.364													72	23	---	---	---	---					
SIDT2	51092	broad.mit.edu	37	11	117058116	117058118	+	In_Frame_Del	DEL	TTC	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr11:117058116_117058118delTTC	uc001pqh.1	+	11	1079_1081	c.1038_1040delTTC	c.(1036-1041)GATTCT>GAT	p.S347del	SIDT2_uc010rxe.1_In_Frame_Del_p.S347del|SIDT2_uc001pqg.2_In_Frame_Del_p.S347del|SIDT2_uc001pqi.1_In_Frame_Del_p.S351del	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	347	Cytoplasmic (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		TCCTGGCTGATTCTTTTCCTGGC	0.517													58	97	---	---	---	---					
DLGAP5	9787	broad.mit.edu	37	14	55655750	55655751	+	Frame_Shift_Ins	INS	-	AT	AT			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr14:55655750_55655751insAT	uc001xbs.2	-	2	364_365	c.147_148insAT	c.(145-150)GATGTAfs	p.D49fs	DLGAP5_uc001xbt.2_Frame_Shift_Ins_p.D49fs	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	49_50					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						GGAATGTTTACATCTTTCAAAC	0.347													28	15	---	---	---	---					
DISP2	85455	broad.mit.edu	37	15	40661086	40661086	+	Frame_Shift_Del	DEL	A	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr15:40661086delA	uc001zlk.1	+	8	2862	c.2773delA	c.(2773-2775)AATfs	p.N925fs		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	925					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		GCTCTTCTACAATGAGGTCAG	0.602													40	60	---	---	---	---					
VPS24	51652	broad.mit.edu	37	2	86790455	86790455	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr2:86790455delT	uc002srj.2	-	1	146	c.17delA	c.(16-18)AAGfs	p.K6fs	VPS24_uc002srk.2_5'UTR|VPS24_uc002srl.2_Frame_Shift_Del_p.K6fs|VPS24_uc010ytl.1_Intron	NM_016079	NP_057163	Q9Y3E7	CHMP3_HUMAN	vacuolar protein sorting 24 isoform 1	6	Intramolecular interaction with C- terminus.				cell cycle|cell division|cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			central_nervous_system(1)	1						CTCCTGGGTCTTTCCAAACAG	0.632													93	127	---	---	---	---					
TTC3	7267	broad.mit.edu	37	21	38568034	38568035	+	Frame_Shift_Ins	INS	-	T	T			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr21:38568034_38568035insT	uc002yvz.2	+	42	5381_5382	c.5276_5277insT	c.(5275-5277)TCTfs	p.S1759fs	TTC3_uc002ywa.2_Frame_Shift_Ins_p.S1759fs|TTC3_uc002ywb.2_Frame_Shift_Ins_p.S1759fs|TTC3_uc010gnf.2_Frame_Shift_Ins_p.S1524fs|TTC3_uc002ywc.2_Frame_Shift_Ins_p.S1449fs	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1759					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				CTTGTGACTTCTGCAAGCGACG	0.569													129	176	---	---	---	---					
KIAA1109	84162	broad.mit.edu	37	4	123229112	123229112	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr4:123229112delT	uc003ieh.2	+	56	9895	c.9850delT	c.(9850-9852)TTTfs	p.F3284fs	KIAA1109_uc003iel.1_Frame_Shift_Del_p.F1219fs	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3284					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGCTGTGCTGTTTTGGCTGAA	0.343													65	108	---	---	---	---					
HSPA9	3313	broad.mit.edu	37	5	137904733	137904733	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr5:137904733delT	uc003ldf.2	-	5	524	c.416delA	c.(415-417)AATfs	p.N139fs	HSPA9_uc011cyw.1_Frame_Shift_Del_p.N70fs	NM_004134	NP_004125	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 precursor	139					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AAAGGGAACATTTTTACTGTA	0.403													40	63	---	---	---	---					
COL19A1	1310	broad.mit.edu	37	6	70866589	70866589	+	Frame_Shift_Del	DEL	G	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr6:70866589delG	uc003pfc.1	+	34	2383	c.2266delG	c.(2266-2268)GGGfs	p.G756fs	COL19A1_uc010kam.1_Frame_Shift_Del_p.G652fs	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	756	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGGCTACCCTGGGATACCTGG	0.378													7	14	---	---	---	---					
FERD3L	222894	broad.mit.edu	37	7	19184646	19184646	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr7:19184646delT	uc003suo.1	-	1	399	c.340delA	c.(340-342)ATGfs	p.M114fs	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	114	Helix-loop-helix motif.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						AGGTTGAACATCCGCTTCCTT	0.557													26	54	---	---	---	---					
SEMA3D	223117	broad.mit.edu	37	7	84636164	84636164	+	Frame_Shift_Del	DEL	G	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr7:84636164delG	uc003uic.2	-	16	1902	c.1862delC	c.(1861-1863)ACTfs	p.T621fs	SEMA3D_uc010led.2_Frame_Shift_Del_p.T621fs|SEMA3D_uc003uib.2_Frame_Shift_Del_p.T260fs	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	621	Ig-like C2-type.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CCATTTAATAGTTGCTTGTTG	0.388													305	136	---	---	---	---					
NEIL2	252969	broad.mit.edu	37	8	11637150	11637150	+	Frame_Shift_Del	DEL	A	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr8:11637150delA	uc003wug.2	+	3	857	c.182delA	c.(181-183)GAAfs	p.E61fs	NEIL2_uc003wue.2_Frame_Shift_Del_p.E61fs|NEIL2_uc003wuf.2_5'UTR|NEIL2_uc011kxd.1_Intron	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	61					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		CTAGATGAAGAAATGGGGCCC	0.527								BER_DNA_glycosylases					91	99	---	---	---	---					
RAD54B	25788	broad.mit.edu	37	8	95419720	95419720	+	Frame_Shift_Del	DEL	T	-	-			TCGA-GL-8500-01A-11D-2396-08	TCGA-GL-8500-11A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	41177191-296c-48e7-945d-6b382e01efef	254114d7-ccd3-44cb-a582-8e0d8fe177b2	g.chr8:95419720delT	uc003ygk.2	-	5	826	c.728delA	c.(727-729)AATfs	p.N243fs	RAD54B_uc010may.1_Frame_Shift_Del_p.N50fs|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			ATTCTGTCTATTTTCCTTTGA	0.353								Direct_reversal_of_damage|Homologous_recombination					58	59	---	---	---	---					
