Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLCH2	9651	broad.mit.edu	37	1	2411404	2411404	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr1:2411404G>A	uc001aji.1	+	3	777	c.503G>A	c.(502-504)CGC>CAC	p.R168H	PLCH2_uc010nyz.1_5'Flank|PLCH2_uc009vle.1_5'Flank|PLCH2_uc001ajj.1_5'Flank|PLCH2_uc001ajk.1_5'Flank	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	168					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CGCCGCCAGCGCACCAGGGAC	0.687000													18	49					0	0	0.012319	0	0
AADACL4	343066	broad.mit.edu	37	1	12711261	12711261	+	Silent	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr1:12711261G>A	uc001auf.2	+	2	288	c.288G>A	c.(286-288)ACG>ACA	p.T96T		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	96	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GTTTTGGGACGATACCCGTGA	0.517000													31	53					0	0	0.009535	0	0
ZNF362	149076	broad.mit.edu	37	1	33745746	33745746	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr1:33745746C>T	uc001bxc.1	+	5	541	c.371C>T	c.(370-372)ACC>ATC	p.T124I		NM_152493	NP_689706	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TCCACCCGGACCCCGTCTGTG	0.682000													12	58					0	0	0.013537	0	0
DAB1	1600	broad.mit.edu	37	1	57756661	57756661	+	Silent	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr1:57756661G>A	uc001cys.1	-	4	716	c.42C>T	c.(40-42)AGC>AGT	p.S14S	DAB1_uc001cyt.1_Silent_p.S14S|DAB1_uc001cyq.1_Silent_p.S14S|DAB1_uc001cyr.1_Silent_p.S14S|DAB1_uc009vzw.1_Silent_p.S14S|DAB1_uc009vzx.1_Silent_p.S14S	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	14					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CTTTCTTGGCGCTGGTTTTCA	0.443000													27	64					0	0	0.006320	0	0
CDC14A	8556	broad.mit.edu	37	1	100818540	100818540	+	Silent	SNP	G	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr1:100818540G>T	uc001dtg.3	+	1	518	c.30G>T	c.(28-30)GGG>GGT	p.G10G	CDC14A_uc009web.2_Intron|CDC14A_uc010oui.1_Intron|CDC14A_uc001dte.3_Silent_p.G10G|CDC14A_uc001dtf.2_Silent_p.G10G|CDC14A_uc009wed.1_5'UTR|CDC14A_uc009wee.2_Silent_p.G10G|CDC14A_uc009wec.1_Silent_p.G10G	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	10	A.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		AACTAATCGGGGCTTGTGAGT	0.627000													18	49					6.33239e-15	8.24405e-15	0.010504	1	0
RRM1	6240	broad.mit.edu	37	11	4159521	4159521	+	Missense_Mutation	SNP	G	A	A	rs112706528		TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr11:4159521G>A	uc001lyw.3	+	19	2606	c.2287G>A	c.(2287-2289)GTA>ATA	p.V763I	RRM1_uc009yej.2_RNA|RRM1_uc009yei.2_Missense_Mutation_p.V723I|RRM1_uc010qyc.1_Missense_Mutation_p.V666I|RRM1_uc010qyd.1_Missense_Mutation_p.V425I	NM_001033	NP_001024	P23921	RIR1_HUMAN	ribonucleoside-diphosphate reductase M1 chain	763					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	TAAAGAAAAGGTATCAAAAGA	0.418000													17	55					0	0	0.006122	0	0
OR4S1	256148	broad.mit.edu	37	11	48328354	48328354	+	Missense_Mutation	SNP	G	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr11:48328354G>T	uc010rhu.1	+	1	580	c.580G>T	c.(580-582)GGT>TGT	p.G194C		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S,	194	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTACATGGTAGGTCTCATCGT	0.453000													41	64					6.45866e-13	8.25273e-13	0.008740	1	0
OR8K1	390157	broad.mit.edu	37	11	56113589	56113589	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr11:56113589C>A	uc010rjg.1	+	1	75	c.75C>A	c.(73-75)GAC>GAA	p.D25E		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GGATTACAGACAACCCTGGGC	0.443000										HNSCC(65;0.19)			15	65					2.89027e-11	3.49875e-11	0.014323	1	0
Unknown	0	broad.mit.edu	37	11	71513938	71513938	+	RNA	SNP	T	A	A	rs139766133	by1000genomes	TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr11:71513938T>A	uc001oqx.1	-	3		c.662A>T								Homo sapiens cDNA clone IMAGE:5297769.																		GGCAAACAGCTCCTGAACATG	0.582000													3	25					0	0	0.001168	0	0
ZNF202	7753	broad.mit.edu	37	11	123601198	123601198	+	Silent	SNP	C	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr11:123601198C>A	uc001pzd.1	-	4	799	c.399G>T	c.(397-399)CGG>CGT	p.R133R	ZNF202_uc001pzc.1_Intron|ZNF202_uc001pze.1_Silent_p.R133R|ZNF202_uc001pzf.1_Silent_p.R133R	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	133					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TCCTCACCCACCGCCTTGGTC	0.582000													35	82					1.69901e-12	2.13149e-12	0.005524	1	0
FGF6	2251	broad.mit.edu	37	12	4553372	4553372	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr12:4553372C>T	uc001qmr.1	-	2	421	c.377G>A	c.(376-378)GGC>GAC	p.G126D		NM_020996	NP_066276	P10767	FGF6_HUMAN	fibroblast growth factor 6 precursor	126					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			lung(2)|ovary(1)	3			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			ACTCACCACGCCTCGCTCCAC	0.542000													21	41					0	0	0.002780	0	0
Unknown	0	broad.mit.edu	37	12	8048160	8048160	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr12:8048160C>G	uc001qtp.1	+	2	148	c.68C>G	c.(67-69)GCA>GGA	p.A23G						RecName: Full=Putative homeobox protein NANOG2;																		CCCACTACTGCAGAGAAGAGT	0.478000													33	89					0	0	0.003271	0	0
PKP2	5318	broad.mit.edu	37	12	32974416	32974416	+	Silent	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr12:32974416G>A	uc001rlj.3	-	10	2134	c.2019C>T	c.(2017-2019)GGC>GGT	p.G673G	PKP2_uc001rlk.3_Silent_p.G629G|PKP2_uc010skj.1_Silent_p.G626G	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	673	ARM 5.		G -> V (in a patient with arrhythmogenic right ventricular cardiomyopathy).		cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GCCACTCCACGCCCTTGGGGT	0.493000													22	72					0	0	0.002780	0	0
NOS1	4842	broad.mit.edu	37	12	117705872	117705872	+	Silent	SNP	A	G	G			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr12:117705872A>G	uc001twm.1	-	11	2603	c.1917T>C	c.(1915-1917)AAT>AAC	p.N639N		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	639					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GAACCGCGATATTGATCTCCA	0.512000													29	62					0	0	0.010818	0	0
FSCB	84075	broad.mit.edu	37	14	44974261	44974261	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr14:44974261C>T	uc001wvn.2	-	1	2239	c.1930G>A	c.(1930-1932)GCT>ACT	p.A644T		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	644	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TGAACTTCAGCGGGGGCCTCC	0.662000													4	15					0	0	0.000602	0	0
GOLGA8DP	100132979	broad.mit.edu	37	15	22709152	22709152	+	Missense_Mutation	SNP	G	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr15:22709152G>T	uc010axw.2	-	11	1245	c.347C>A	c.(346-348)GCG>GAG	p.A116E	GOLGA8DP_uc010axx.2_Missense_Mutation_p.A116E|uc010tzw.1_5'Flank	NM_001012423	NP_001012423			golgi autoantigen, golgin subfamily a, 8E												0						GGCCTGGAGCGCTCCTGCCAC	0.607000													3	32					1.23904e-05	1.35704e-05	0.000602	1	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652000													5	24					0	0	0.001984	0	0
LOC283867	283867	broad.mit.edu	37	16	65319330	65319330	+	RNA	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr16:65319330G>A	uc010cdo.1	-	6		c.492C>T			LOC283867_uc010cdp.1_RNA|LOC283867_uc002eol.1_RNA					Homo sapiens cDNA clone IMAGE:5276218.												0				OV - Ovarian serous cystadenocarcinoma(108;0.17)		AATGCTTGGCGGTCTTGTGTG	0.393000													14	60					0	0	0.004990	0	0
NF1	4763	broad.mit.edu	37	17	29563007	29563007	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr17:29563007G>A	uc002hgg.2	+	29	4275	c.3942G>A	c.(3940-3942)TGG>TGA	p.W1314*	NF1_uc002hgh.2_Nonsense_Mutation_p.W1314*|NF1_uc010csn.1_Nonsense_Mutation_p.W1174*|NF1_uc002hgi.1_Nonsense_Mutation_p.W347*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1314	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CCTCTGATTGGCAACATGTTA	0.348000			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			31	43					0	0	0.013726	0	0
SPACA3	124912	broad.mit.edu	37	17	31323997	31323997	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr17:31323997C>A	uc002hhs.1	+	3	555	c.480C>A	c.(478-480)AAC>AAA	p.N160K	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	160	Extracellular (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			ACGTCCCCAACGTGTGCCGGA	0.582000													32	40					1.414e-09	1.68217e-09	0.003755	1	0
KIAA0802	23255	broad.mit.edu	37	18	8821483	8821483	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr18:8821483G>A	uc002knr.2	+	14	3317	c.3175G>A	c.(3175-3177)GGA>AGA	p.G1059R	KIAA0802_uc002knq.2_Missense_Mutation_p.G1018R|KIAA0802_uc002kns.2_Missense_Mutation_p.G399R	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1369											0						AAATCACAAAGGAAATCTTCA	0.299000													11	32					0	0	0.010729	0	0
ACAA2	10449	broad.mit.edu	37	18	47311703	47311703	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr18:47311703G>A	uc002ldw.3	-	9	1370	c.973C>T	c.(973-975)CCC>TCC	p.P325S	ACAA2_uc002ldx.3_Missense_Mutation_p.P322S	NM_006111	NP_006102	P42765	THIM_HUMAN	acetyl-coenzyme A acyltransferase 2	325					anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1						AAGTACTGGGGAGCAAAAGCT	0.403000													5	24					0	0	0.000602	0	0
SERPINB4	6318	broad.mit.edu	37	18	61326675	61326675	+	Silent	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr18:61326675G>A	uc002ljg.2	-	3	335	c.309C>T	c.(307-309)ATC>ATT	p.I103I	SERPINB3_uc002lji.2_Silent_p.I103I|SERPINB3_uc010dqa.2_Silent_p.I103I|SERPINB3_uc010dqb.2_Silent_p.I103I			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	103					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						GCTTGTTGGCGATCTTCAGCT	0.398000													28	89					0	0	0.004656	0	0
UNC13A	23025	broad.mit.edu	37	19	17778978	17778978	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr19:17778978C>A	uc002nhd.2	-	7	680	c.680G>T	c.(679-681)CGC>CTC	p.R227L		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	139					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GGCCCAGTAGCGAGCCTCCTC	0.582000													12	30					5.50884e-06	6.1308e-06	0.013537	1	0
HAUS5	23354	broad.mit.edu	37	19	36108982	36108982	+	Missense_Mutation	SNP	A	G	G			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr19:36108982A>G	uc002oam.1	+	10	757	c.706A>G	c.(706-708)ACA>GCA	p.T236A		NM_015302	NP_056117	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	236					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle					0						GACGCTGCTGACAAACCACCC	0.637000													44	142					0	0	0.007835	0	0
PLEK	5341	broad.mit.edu	37	2	68620306	68620306	+	Missense_Mutation	SNP	A	G	G			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr2:68620306A>G	uc002sen.3	+	7	937	c.775A>G	c.(775-777)AAA>GAA	p.K259E	PLEK_uc010fde.2_Missense_Mutation_p.K259E	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	259	PH 2.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GCATAGAAGGAAAAACTGGAA	0.433000													51	127					0	0	0.014410	0	0
ANTXR1	84168	broad.mit.edu	37	2	69409664	69409664	+	Missense_Mutation	SNP	A	G	G			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr2:69409664A>G	uc002sfg.2	+	16	1581	c.1225A>G	c.(1225-1227)AAG>GAG	p.K409E		NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	409	Cytoplasmic (Potential).				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						AGAAGGTGCTAAGTTGGAAAA	0.433000									Familial_Infantile_Hemangioma				23	46					0	0	0.014323	0	0
SF3B1	23451	broad.mit.edu	37	2	198273241	198273241	+	Silent	SNP	A	G	G			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr2:198273241A>G	uc002uue.2	-	8	1017	c.969T>C	c.(967-969)ATT>ATC	p.I323I		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	323	Interaction with PPP1R8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTGTTTCACCAATAGAATCTC	0.468000													31	71					0	0	0.010818	0	0
ACSS1	84532	broad.mit.edu	37	20	24988511	24988511	+	Missense_Mutation	SNP	T	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr20:24988511T>A	uc002wub.2	-	14	2835	c.1957A>T	c.(1957-1959)ACT>TCT	p.T653S	ACSS1_uc002wuc.2_Missense_Mutation_p.T651S|ACSS1_uc010gdc.2_Missense_Mutation_p.T448S|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Missense_Mutation_p.T570S	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	653					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCCTCACTAGTGATGATCTTC	0.562000													4	117					0	0	0.000602	0	0
TRPC4AP	26133	broad.mit.edu	37	20	33657162	33657162	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr20:33657162C>A	uc002xbk.2	-	3	385	c.351G>T	c.(349-351)AGG>AGT	p.R117S	TRPC4AP_uc002xbl.2_Missense_Mutation_p.R117S|TRPC4AP_uc010zur.1_Intron|TRPC4AP_uc002xbm.1_Missense_Mutation_p.R117S	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	117	Interaction with TNFRSF1A (By similarity).				protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GGGTAAGTTTCCTCTCTTCAG	0.333000													15	105					4.7546e-09	5.56047e-09	0.004007	1	0
ZNF831	128611	broad.mit.edu	37	20	57829784	57829784	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr20:57829784G>A	uc002yan.2	+	5	5020	c.5020G>A	c.(5020-5022)GTT>ATT	p.V1674I		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1674						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGACCGATTAGTTATAGAAAT	0.443000													15	78					0	0	0.004007	0	0
LOC96610	96610	broad.mit.edu	37	22	22664115	22664115	+	RNA	SNP	A	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr22:22664115A>T	uc011aim.1	+	30		c.1972A>T			LOC96610_uc011aiq.1_RNA					Parts of antibodies, mostly variable regions.												0						TGTTTAATTCAGCCTTGGAAG	0.413000													4	80					0	0	0.010729	0	0
VGLL3	389136	broad.mit.edu	37	3	87027678	87027678	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr3:87027678C>T	uc003dqn.2	-	2	765	c.401G>A	c.(400-402)CGA>CAA	p.R134Q		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		ATTCTTACCTCGCCATAGGGG	0.502000													34	97					0	0	0.003271	0	0
PDE6B	5158	broad.mit.edu	37	4	619541	619541	+	Silent	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr4:619541G>A	uc003gap.2	+	1	179	c.126G>A	c.(124-126)CCG>CCA	p.P42P	PDE6B_uc003gao.3_Silent_p.P42P	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	42					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						GGTGCCCGCCGGACTGCGACA	0.522000													17	36					0	0	0.007413	0	0
WDFY3	23001	broad.mit.edu	37	4	85612794	85612794	+	Missense_Mutation	SNP	T	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr4:85612794T>A	uc003hpd.2	-	60	9602	c.9194A>T	c.(9193-9195)GAG>GTG	p.E3065V	WDFY3_uc003hpe.1_Missense_Mutation_p.E676V	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	3065						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CTTGTCTGACTCATAGGTTCC	0.438000													28	52					0	0	0.012213	0	0
FSTL5	56884	broad.mit.edu	37	4	162463805	162463805	+	Silent	SNP	T	C	C			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr4:162463805T>C	uc003iqh.2	-	9	1492	c.1056A>G	c.(1054-1056)AGA>AGG	p.R352R	FSTL5_uc003iqi.2_Silent_p.R351R|FSTL5_uc010iqv.2_Silent_p.R351R	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	352	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CCCCAGGCTCTCTAGCCTGAC	0.423000													33	78					0	0	0.005524	0	0
DNAH5	1767	broad.mit.edu	37	5	13923478	13923478	+	Missense_Mutation	SNP	C	T	T	rs116128702	by1000genomes	TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr5:13923478C>T	uc003jfd.2	-	4	391	c.349G>A	c.(349-351)GAG>AAG	p.E117K	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	117	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCGTTTCCCTCGGTCACGAAC	0.448000									Kartagener_syndrome				67	134					0	0	0.014410	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41055887	41055887	+	Silent	SNP	T	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr5:41055887T>A	uc003jmj.3	-	10	1480	c.990A>T	c.(988-990)CGA>CGT	p.R330R	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	330	HEAT 4.						binding			ovary(6)|central_nervous_system(2)	8						AGATTCCCACTCGAATGGCTT	0.413000													40	88					0	0	0.011902	0	0
GABRG2	2566	broad.mit.edu	37	5	161580182	161580182	+	Silent	SNP	C	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr5:161580182C>T	uc003lyz.3	+	9	1570	c.1212C>T	c.(1210-1212)TAC>TAT	p.Y404Y	GABRG2_uc010jjc.2_Silent_p.Y452Y|GABRG2_uc003lyy.3_Silent_p.Y412Y|GABRG2_uc011dej.1_Silent_p.Y309Y	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	404	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		ATGAAGAGTACGGCTATGAGT	0.488000													7	131					0	0	0.001984	0	0
ULBP1	80329	broad.mit.edu	37	6	150289853	150289853	+	Missense_Mutation	SNP	T	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr6:150289853T>A	uc003qnp.2	+	2	239	c.196T>A	c.(196-198)TGT>AGT	p.C66S		NM_025218	NP_079494	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1 precursor	66	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			pancreas(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		TCACTATGACTGTGTTAACCA	0.453000													60	71					0	0	0.014410	0	0
C7orf34	135927	broad.mit.edu	37	7	142637545	142637545	+	Silent	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr7:142637545G>A	uc003wca.2	+	2	356	c.315G>A	c.(313-315)ACG>ACA	p.T105T		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	80						extracellular region					0	Melanoma(164;0.059)					CGTCCAAGACGGCAGCTGTTC	0.532000													48	174					0	0	0.014410	0	0
MLL3	58508	broad.mit.edu	37	7	151945104	151945104	+	Missense_Mutation	SNP	A	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr7:151945104A>T	uc003wla.2	-	14	2634	c.2415T>A	c.(2413-2415)AGT>AGA	p.S805R		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	805					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CAGCAGAGGAACTAAGAGCTG	0.438000			N		medulloblastoma								51	785					0	0	0.014410	0	0
PSD3	23362	broad.mit.edu	37	8	18725328	18725328	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr8:18725328G>C	uc003wza.2	-	4	1593	c.1490C>G	c.(1489-1491)TCA>TGA	p.S497*		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	497					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TCCTCCCCCTGATGTCCTCTC	0.488000													74	180					0	0	0.014410	0	0
TLN1	7094	broad.mit.edu	37	9	35714763	35714763	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr9:35714763G>C	uc003zxt.2	-	22	3219	c.2865C>G	c.(2863-2865)AGC>AGG	p.S955R		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	955					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TTACCTTGCAGCTCTGCACCA	0.597000													11	184					0	0	0.010729	0	0
FAM120A	23196	broad.mit.edu	37	9	96326729	96326729	+	Silent	SNP	C	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr9:96326729C>T	uc004atw.2	+	18	3289	c.3264C>T	c.(3262-3264)TGC>TGT	p.C1088C	FAM120A_uc004aty.2_Silent_p.C869C|FAM120A_uc004atz.2_Silent_p.C736C|FAM120A_uc010mrg.2_Silent_p.C355C|FAM120A_uc004aua.1_RNA	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	1088	RNA binding.					cytoplasm|plasma membrane	RNA binding				0						CTAAAACGTGCAATACAAATC	0.502000													10	171					0	0	0.001855	0	0
KIAA0368	23392	broad.mit.edu	37	9	114246646	114246646	+	Silent	SNP	A	C	C			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr9:114246646A>C	uc004bfe.1	-	2	267	c.267T>G	c.(265-267)CCT>CCG	p.P89P	KIAA0368_uc010muc.1_5'Flank	NM_001080398	NP_001073867			KIAA0368 protein												0						GCCTGTCCAAAGGAAGAGACG	0.697000													9	24					0	0	0.010729	0	0
TMEM27	57393	broad.mit.edu	37	X	15682843	15682843	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chrX:15682843G>C	uc004cxc.1	-	1	312	c.56C>G	c.(55-57)CCA>CGA	p.P19R		NM_020665	NP_065716	Q9HBJ8	TMM27_HUMAN	transmembrane protein 27 precursor	19	Extracellular (Potential).				proteolysis	integral to membrane	metallopeptidase activity|peptidyl-dipeptidase activity			ovary(1)	1	Hepatocellular(33;0.183)					CTACATACCTGGTTGACAGAG	0.363000													33	63					0	0	0.004289	0	0
MAP7D2	256714	broad.mit.edu	37	X	20044027	20044027	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chrX:20044027G>A	uc004czr.1	-	8	947	c.928C>T	c.(928-930)CCT>TCT	p.P310S	MAP7D2_uc004czq.1_Missense_Mutation_p.P195S|MAP7D2_uc011mji.1_Missense_Mutation_p.P258S|MAP7D2_uc010nfo.1_Missense_Mutation_p.P351S|MAP7D2_uc011mjj.1_Missense_Mutation_p.P265S	NM_152780	NP_689993	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	310										ovary(2)|breast(1)	3						GGGTAGGGAGGTTTCGTTGTC	0.488000													99	245					0	0	0.014410	0	0
DMD	1756	broad.mit.edu	37	X	31747756	31747756	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chrX:31747756G>A	uc004dda.1	-	52	7896	c.7652C>T	c.(7651-7653)ACG>ATG	p.T2551M	DMD_uc004dcr.1_Missense_Mutation_p.T91M|DMD_uc004dcs.1_Missense_Mutation_p.T91M|DMD_uc004dct.1_Missense_Mutation_p.T91M|DMD_uc004dcu.1_Missense_Mutation_p.T91M|DMD_uc004dcv.1_Missense_Mutation_p.T91M|DMD_uc004dcw.2_Missense_Mutation_p.T1207M|DMD_uc004dcx.2_Missense_Mutation_p.T1210M|DMD_uc004dcz.2_Missense_Mutation_p.T2428M|DMD_uc004dcy.1_Missense_Mutation_p.T2547M|DMD_uc004ddb.1_Missense_Mutation_p.T2543M|DMD_uc004ddd.1_Missense_Mutation_p.T91M	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2551	Spectrin 17.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ACTTCGATCCGTAATGATTGT	0.393000													69	157					0	0	0.014410	0	0
BCOR	54880	broad.mit.edu	37	X	39932304	39932304	+	Silent	SNP	G	A	A			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chrX:39932304G>A	uc004den.3	-	4	2587	c.2295C>T	c.(2293-2295)TCC>TCT	p.S765S	BCOR_uc004dep.3_Silent_p.S765S|BCOR_uc004deo.3_Silent_p.S765S|BCOR_uc004dem.3_Silent_p.S765S|BCOR_uc004deq.3_Silent_p.S765S	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	765					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CCAAAATCTCGGAAAACCGAT	0.512000													99	209					0	0	0.014410	0	0
ZNF41	7592	broad.mit.edu	37	X	47308566	47308566	+	Missense_Mutation	SNP	G	T	T			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chrX:47308566G>T	uc004dhs.3	-	4	796	c.729C>A	c.(727-729)AAC>AAA	p.N243K	ZNF41_uc004dhu.3_Missense_Mutation_p.N235K|ZNF41_uc004dht.3_Missense_Mutation_p.N115K|ZNF41_uc004dhv.3_Missense_Mutation_p.N211K|ZNF41_uc004dhw.3_Missense_Mutation_p.N203K|ZNF41_uc004dhy.3_Missense_Mutation_p.N201K|ZNF41_uc004dhx.3_Missense_Mutation_p.N201K|ZNF41_uc011mlm.1_Missense_Mutation_p.N115K	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	243						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				GATTATGTGAGTTTAAAGTAT	0.328000													46	117					6.87076e-12	8.46576e-12	0.014410	1	0
PABPC3	5042	broad.mit.edu	37	13	25671333	25671333	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr13:25671333delA	uc001upy.2	+	1	1058	c.997delA	c.(997-999)AAAfs	p.K333fs		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	333	RRM 4.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TGGTCGCAGCAAAGGGTTTGG	0.428													7	310	---	---	---	---					
GDPD3	79153	broad.mit.edu	37	16	30119725	30119725	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr16:30119725delG	uc002dwp.2	-	8	815	c.736delC	c.(736-738)CTGfs	p.L246fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Frame_Shift_Del_p.L184fs	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	246	GDPD.|Cytoplasmic (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						AACTGGTTCAGGCAAGAGCAG	0.577													128	214	---	---	---	---					
PCDHB1	29930	broad.mit.edu	37	5	140431875	140431875	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CS-5397-01A-01D-1893-08	TCGA-CS-5397-10A-03D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	9932b51d-ebd9-4cbc-8c8c-83a5661a16c0	41c76fb1-1c57-4b6b-92f9-835ea17dbe23	g.chr5:140431875delA	uc003lik.1	+	1	897	c.820delA	c.(820-822)AACfs	p.N274fs		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	274	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAGGGCACCAACAAAGCGAT	0.512													14	47	---	---	---	---					
