Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WDR3	10885	broad.mit.edu	37	1	118483783	118483783	+	Missense_Mutation	SNP	C	T	T	rs150881258		TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr1:118483783C>T	uc010oxe.1	+	8	892	c.826C>T	c.(826-828)CGG>TGG	p.R276W	WDR3_uc001ehi.2_Intron|WDR3_uc001ehh.2_Missense_Mutation_p.R105W	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	276						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TTCCATAATGCGGGAAGGAAG	0.423000													18	102					0	0	0.062417	0	0
RBP3	5949	broad.mit.edu	37	10	48390167	48390167	+	Silent	SNP	G	A	A			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr10:48390167G>A	uc001jez.2	-	1	825	c.711C>T	c.(709-711)GGC>GGT	p.G237G		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	237	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CCTCGGCCACGCCCCTGGTCT	0.657000													25	64					0	0	0.076483	0	0
TNNT3	7140	broad.mit.edu	37	11	1956135	1956135	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr11:1956135C>T	uc001luu.3	+	14	879	c.667C>T	c.(667-669)CGC>TGC	p.R223C	TNNT3_uc001lun.2_Missense_Mutation_p.R119C|TNNT3_uc001luw.3_Missense_Mutation_p.R215C|TNNT3_uc001luo.3_Missense_Mutation_p.R215C|TNNT3_uc001lup.3_Missense_Mutation_p.R221C|TNNT3_uc001luq.3_Missense_Mutation_p.R215C|TNNT3_uc001lur.2_Missense_Mutation_p.R215C|TNNT3_uc010qxf.1_Missense_Mutation_p.R221C|TNNT3_uc010qxg.1_Missense_Mutation_p.R155C	NM_006757	NP_006748	P45378	TNNT3_HUMAN	troponin T3, skeletal, fast isoform 1	234					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding	p.R223C(1)		ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		GAAGCTGAAACGCCAGAAATA	0.612000													5	185					0	0	0.014758	0	0
OR51V1	283111	broad.mit.edu	37	11	5221701	5221701	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr11:5221701A>G	uc010qyz.1	-	1	230	c.230T>C	c.(229-231)CTC>CCC	p.L77P		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGTCAGTGAGGGCCAGCAT	0.537000													6	66					0	0	0.038147	0	0
PRDM11	56981	broad.mit.edu	37	11	45245878	45245878	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr11:45245878C>T	uc001myo.2	+	8	1204	c.955C>T	c.(955-957)CGT>TGT	p.R319C		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	319										upper_aerodigestive_tract(1)	1						TCCCTACAAGCGTGGCTTTGA	0.507000													17	274					0	0	0.033300	0	0
ACTR10	55860	broad.mit.edu	37	14	58675824	58675824	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr14:58675824A>G	uc001xdf.2	+	4	444	c.341A>G	c.(340-342)GAG>GGG	p.E114G	C14orf37_uc010tro.1_Intron|ACTR10_uc001xdg.2_5'UTR|ACTR10_uc001xdh.2_5'UTR	NM_018477	NP_060947	Q9NZ32	ARP10_HUMAN	uncharacterized hypothalamus protein HARP11	114						cytoplasm				central_nervous_system(1)	1						AAATATTTTGAGGTACCTGTC	0.333000													5	113					0	0	0.014758	0	0
HEATR4	399671	broad.mit.edu	37	14	73989793	73989793	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr14:73989793G>A	uc010tub.1	-	3	386	c.64C>T	c.(64-66)CGA>TGA	p.R22*	HEATR4_uc010tua.1_Translation_Start_Site	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		CATCCCAGTCGTGGGGGCAGT	0.517000													10	51					0	0	0.058154	0	0
Unknown	0	broad.mit.edu	37	15	20658903	20658903	+	Missense_Mutation	SNP	T	C	C			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr15:20658903T>C	uc001ytg.2	-	14	1983	c.1274A>G	c.(1273-1275)CAA>CGA	p.Q425R	uc010tyx.1_Intron|uc001yth.3_Missense_Mutation_p.Q425R|uc010tyy.1_Missense_Mutation_p.Q425R|uc010tyz.1_Missense_Mutation_p.Q273R					RecName: Full=Putative HERC2-like protein 3;																		AATAAGTCTTTGCCATCCACA	0.368000													6	143					0	0	0.080935	0	0
TP53	7157	broad.mit.edu	37	17	7577547	7577547	+	Missense_Mutation	SNP	C	T	T	rs121912656		TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr17:7577547C>T	uc002gim.2	-	7	928	c.734G>A	c.(733-735)GGC>GAC	p.G245D	TP53_uc002gig.1_Missense_Mutation_p.G245D|TP53_uc002gih.2_Missense_Mutation_p.G245D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113D|TP53_uc010cng.1_Missense_Mutation_p.G113D|TP53_uc002gii.1_Missense_Mutation_p.G113D|TP53_uc010cnh.1_Missense_Mutation_p.G245D|TP53_uc010cni.1_Missense_Mutation_p.G245D|TP53_uc002gij.2_Missense_Mutation_p.G245D|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152D|TP53_uc002gio.2_Missense_Mutation_p.G113D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245del(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	28					0	0	0.069288	0	0
Unknown	0	broad.mit.edu	37	17	45105705	45105705	+	RNA	SNP	A	G	G	rs147936028	by1000genomes	TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr17:45105705A>G	uc010wki.1	+	5		c.1307A>G								Homo sapiens cDNA FLJ42521 fis, clone BRACE3000973.																		GCCTGGCACGAAATGCAGTTT	0.303000													3	224					0	0	0.004672	0	0
LGALS13	29124	broad.mit.edu	37	19	40095291	40095291	+	Missense_Mutation	SNP	T	A	A			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr19:40095291T>A	uc002omb.2	+	2	105	c.65T>A	c.(64-66)ATC>AAC	p.I22N		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13	22	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			TGCGTGATAATCAAAGGGACA	0.473000													6	138					0	0	0.029380	0	0
ZNF582	147948	broad.mit.edu	37	19	56901871	56901871	+	Splice_Site	SNP	C	T	T			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr19:56901871C>T	uc002qmz.1	-	3	169	c.10_splice	c.e3-1	p.G4_splice	ZNF582_uc002qmy.2_Splice_Site_p.G35_splice	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		ATTCTGACCCCTGGAATGACA	0.488000													4	110					0	0	0.009096	0	0
AURKC	6795	broad.mit.edu	37	19	57744018	57744018	+	Silent	SNP	C	T	T	rs141028635		TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr19:57744018C>T	uc002qoe.2	+	4	594	c.405C>T	c.(403-405)AGC>AGT	p.S135S	AURKC_uc002qoc.2_Silent_p.S116S|AURKC_uc002qod.2_Silent_p.S101S|AURKC_uc010etv.2_Silent_p.S132S	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	135	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		TGCAGAAAAGCGAGAAATTAG	0.537000													7	83					0	0	0.038147	0	0
ALMS1	7840	broad.mit.edu	37	2	73800143	73800143	+	Missense_Mutation	SNP	G	C	C			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr2:73800143G>C	uc002sje.1	+	18	11253	c.11142G>C	c.(11140-11142)CAG>CAC	p.Q3714H	ALMS1_uc002sjf.1_Missense_Mutation_p.Q3670H|ALMS1_uc002sjg.2_Missense_Mutation_p.Q3100H|ALMS1_uc002sjh.1_Missense_Mutation_p.Q3100H	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3712					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						AAATTGAACAGATTAAATTTG	0.373000													16	83					0	0	0.033300	0	0
XIRP2	129446	broad.mit.edu	37	2	168110545	168110545	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr2:168110545C>G	uc002udx.2	+	9	10577	c.10559C>G	c.(10558-10560)GCT>GGT	p.A3520G	XIRP2_uc010fpn.2_Missense_Mutation_p.L427V|XIRP2_uc010fpo.2_Missense_Mutation_p.L394V|XIRP2_uc010fpp.2_Missense_Mutation_p.L394V|XIRP2_uc010fpq.2_Missense_Mutation_p.A3298G|XIRP2_uc010fpr.2_Missense_Mutation_p.L172V	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3345					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTTTTAGAAGCTGCTGCTCCA	0.343000													16	97					0	0	0.033300	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	A	A	rs121913499		TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr2:209113113G>A	uc002vcs.2	-	4	640	c.394C>T	c.(394-396)CGT>TGT	p.R132C	IDH1_uc002vct.2_Missense_Mutation_p.R132C|IDH1_uc002vcu.2_Missense_Mutation_p.R132C	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma 								17	68					0	0	0.033300	0	0
LOC100125556	100125556	broad.mit.edu	37	3	125647387	125647387	+	RNA	SNP	G	A	A			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr3:125647387G>A	uc003eif.3	+	5		c.561G>A			LOC100125556_uc003eid.3_RNA|LOC100125556_uc003eie.3_RNA	NR_024251				Homo sapiens family with sequence similarity 86, member A pseudogene, mRNA (cDNA clone IMAGE:4425123).												0						ACCAGAAACTGTTTCCCTATG	0.502000													4	112					0	0	0.014758	0	0
LOC100125556	100125556	broad.mit.edu	37	3	125647396	125647396	+	RNA	SNP	T	C	C			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr3:125647396T>C	uc003eif.3	+	5		c.570T>C			LOC100125556_uc003eid.3_RNA|LOC100125556_uc003eie.3_RNA	NR_024251				Homo sapiens family with sequence similarity 86, member A pseudogene, mRNA (cDNA clone IMAGE:4425123).												0						TGTTTCCCTATGAAGAGCACT	0.502000													4	116					0	0	0.014758	0	0
CCDC158	339965	broad.mit.edu	37	4	77250102	77250102	+	Silent	SNP	G	A	A	rs138548683	by1000genomes	TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr4:77250102G>A	uc003hkb.3	-	21	3102	c.2949C>T	c.(2947-2949)CAC>CAT	p.H983H		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	983	Ser-rich.									skin(3)|ovary(2)|pancreas(1)	6						TGTCTCCTGCGTGTAATGTGA	0.383000													8	71					0	0	0.038147	0	0
PCDHA11	56138	broad.mit.edu	37	5	140248828	140248828	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr5:140248828G>A	uc003lia.2	+	1	998	c.140G>A	c.(139-141)CGC>CAC	p.R47H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R47H	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	47	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGTGGGCCGCATCGCGCAG	0.642000													4	128					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	MT	13463	13463	+	RNA	SNP	G	A	A			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chrM:13463G>A	uc004cox.3	+	1		c.1127G>A			uc004coy.2_5'Flank|uc004coz.1_5'Flank					Homo sapiens NADH dehydrogenase subunit 5 (MTND5) mRNA, RNA 5, complete cds; mitochondrial gene for mitochondrial product.																		CCTCACCATTGGCAGCCTAGC	0.453000													45	22					0	0	0.048971	0	0
TBX22	50945	broad.mit.edu	37	X	79279563	79279563	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chrX:79279563C>T	uc010nmg.1	+	4	492	c.358C>T	c.(358-360)CGG>TGG	p.R120W	TBX22_uc004edi.1_5'UTR|TBX22_uc004edj.1_Missense_Mutation_p.R120W	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	120	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						TTCTTACAGGCGGATGTTCCC	0.483000													21	24					0	0	0.055883	0	0
C12orf40	283461	broad.mit.edu	37	12	40114882	40114885	+	Frame_Shift_Del	DEL	ACAA	-	-			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr12:40114882_40114885delACAA	uc001rmc.2	+	13	1955_1958	c.1788_1791delACAA	c.(1786-1791)ATACAAfs	p.I596fs	C12orf40_uc009zjv.1_Intron	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	596_597										ovary(6)	6						ATGCAGGGATACAAACAGAGAGTG	0.402													23	110	---	---	---	---					
EP400NL	347918	broad.mit.edu	37	12	132603415	132603416	+	RNA	INS	-	GGCAGA	GGCAGA	rs141780032	by1000genomes	TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr12:132603415_132603416insGGCAGA	uc001ujx.1	+	1		c.725_726insGGCAGA								Homo sapiens cDNA FLJ33915 fis, clone CTONG2016658.												0						GCAGCTCGCTGGGCAGAGGCAG	0.673													6	12	---	---	---	---					
BAIAP3	8938	broad.mit.edu	37	16	1397309	1397310	+	Frame_Shift_Ins	INS	-	T	T			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr16:1397309_1397310insT	uc002clk.1	+	29	2867_2868	c.2867_2868insT	c.(2866-2868)AGTfs	p.S956fs	BAIAP3_uc002clj.2_Frame_Shift_Ins_p.S938fs|BAIAP3_uc010uuz.1_Frame_Shift_Ins_p.S921fs|BAIAP3_uc010uva.1_Frame_Shift_Ins_p.S893fs|BAIAP3_uc010uvc.1_Frame_Shift_Ins_p.S885fs	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	956	MHD2.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				GCCCTGGTCAGTTTTTTCCACG	0.639													12	60	---	---	---	---					
ICT1	3396	broad.mit.edu	37	17	73016725	73016727	+	In_Frame_Del	DEL	AAG	-	-			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr17:73016725_73016727delAAG	uc002jmm.2	+	5	511_513	c.509_511delAAG	c.(508-513)AAAGAA>AAA	p.E171del		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	171					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					GAGCCAACAAAAGAAGATGTTAA	0.473													18	60	---	---	---	---					
BSN	8927	broad.mit.edu	37	3	49691063	49691064	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr3:49691063_49691064delCT	uc003cxe.3	+	5	4188_4189	c.4074_4075delCT	c.(4072-4077)AGCTCTfs	p.S1358fs		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1358_1359					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGCTGCACAGCTCTCCTGCCTC	0.629													8	170	---	---	---	---					
CPEB4	80315	broad.mit.edu	37	5	173316976	173316977	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr5:173316976_173316977delAA	uc003mcs.3	+	1	1646_1647	c.240_241delAA	c.(238-243)GCAAAAfs	p.A80fs	CPEB4_uc010jju.1_Frame_Shift_Del_p.A80fs|CPEB4_uc010jjv.2_Frame_Shift_Del_p.A80fs|CPEB4_uc011dfg.1_Frame_Shift_Del_p.A80fs	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	80_81							nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CAGAAAAAGCAAAAAGTCAGCA	0.490													39	165	---	---	---	---					
TTYH3	80727	broad.mit.edu	37	7	2687233	2687234	+	Frame_Shift_Ins	INS	-	G	G			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr7:2687233_2687234insG	uc003smp.2	+	4	774_775	c.587_588insG	c.(586-588)GAGfs	p.E196fs	TTYH3_uc010ksn.2_5'UTR|TTYH3_uc003smq.2_5'Flank	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	196	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		GTGTCGCTGGAGGTGCTGGCGG	0.673													2	4	---	---	---	---					
SRRT	51593	broad.mit.edu	37	7	100482650	100482652	+	In_Frame_Del	DEL	AGG	-	-			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chr7:100482650_100482652delAGG	uc003uwy.2	+	10	1416_1418	c.1148_1150delAGG	c.(1147-1152)AAGGAG>AAG	p.E385del	SRRT_uc010lhl.1_In_Frame_Del_p.E385del|SRRT_uc003uxa.2_In_Frame_Del_p.E385del|SRRT_uc003uwz.2_In_Frame_Del_p.E385del	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	385	Glu-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GAGGAGGAGAAGGAGGAGGCCGG	0.581													15	342	---	---	---	---					
BCOR	54880	broad.mit.edu	37	X	39922031	39922032	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chrX:39922031_39922032delCT	uc004den.3	-	9	4432_4433	c.4140_4141delAG	c.(4138-4143)ACAGGGfs	p.T1380fs	BCOR_uc004dep.3_Frame_Shift_Del_p.T1346fs|BCOR_uc004deo.3_Frame_Shift_Del_p.T1328fs|BCOR_uc010nhb.2_Frame_Shift_Del_p.T88fs|BCOR_uc004dem.3_Frame_Shift_Del_p.T1346fs	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1380_1381					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TAGTATTCCCCTGTCAGTGGCA	0.579													14	27	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76939181	76939184	+	Frame_Shift_Del	DEL	AGGA	-	-			TCGA-DB-5276-01A-01D-1468-08	TCGA-DB-5276-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc6b7655-9307-4c8b-b1f6-f29a4dabd72c	289ad150-2e4f-4d98-9ebc-af05a0b95e7f	g.chrX:76939181_76939184delAGGA	uc004ecp.3	-	9	1796_1799	c.1564_1567delTCCT	c.(1564-1569)TCCTCAfs	p.S522fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.S484fs|ATRX_uc004eco.3_Frame_Shift_Del_p.S307fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.S483fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.S522fs|ATRX_uc010nly.1_Frame_Shift_Del_p.S467fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	522_523					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCTGGAACTGAGGAAGGAACAGAC	0.407			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						72	204	---	---	---	---					
