Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LRRC7	57554	broad.mit.edu	37	1	70504174	70504174	+	Silent	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr1:70504174G>A	uc001dep.2	+	19	2583	c.2553G>A	c.(2551-2553)CCG>CCA	p.P851P	LRRC7_uc009wbg.2_Silent_p.P135P|LRRC7_uc001deq.2_Silent_p.P92P	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	851						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CCCCTAGTCCGTTTGAAGACA	0.478000													75	11					0	0	0.139131	0	0
NEGR1	257194	broad.mit.edu	37	1	72748110	72748110	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr1:72748110C>T	uc001dfw.2	-	1	168	c.68G>A	c.(67-69)AGC>AAC	p.S23N	NEGR1_uc010oqs.1_Missense_Mutation_p.S23N	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	23					cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GCAGCACAGGCTGAGGAGCAC	0.627000													6	14					0	0	0.038147	0	0
ENSA	2029	broad.mit.edu	37	1	150599964	150599964	+	Silent	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr1:150599964G>A	uc001eve.2	-	2	314	c.162C>T	c.(160-162)CTC>CTT	p.L54L	ENSA_uc001evd.2_Silent_p.L54L|ENSA_uc009wly.2_Silent_p.L54L|ENSA_uc001evg.2_Silent_p.L54L|ENSA_uc001evh.2_Silent_p.L54L|ENSA_uc009wlz.1_Silent_p.L54L|ENSA_uc001evi.2_Silent_p.L54L|ENSA_uc001evb.2_Silent_p.L50L|ENSA_uc001evc.2_Silent_p.L50L|ENSA_uc001evf.2_Silent_p.L50L	NM_004436	NP_004427	O43768	ENSA_HUMAN	endosulfine alpha isoform 3	54					cell division|G2/M transition of mitotic cell cycle|mitosis|response to nutrient|transport	cytoplasm	ion channel inhibitor activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity|receptor binding			central_nervous_system(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;9.85e-23)|all cancers(9;5.06e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.67e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000701)|LUSC - Lung squamous cell carcinoma(543;0.171)			GTCTCTTCATGAGGAAGTCGG	0.493000													89	81					0	0	0.139131	0	0
FCRL5	83416	broad.mit.edu	37	1	157491079	157491079	+	Missense_Mutation	SNP	G	A	A	rs142943534		TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr1:157491079G>A	uc001fqu.2	-	11	2401	c.2243C>T	c.(2242-2244)CCG>CTG	p.P748L	FCRL5_uc009wsm.2_Missense_Mutation_p.P748L	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	748	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GCGAGACACCGGAACTGAAAG	0.498000													12	53					0	0	0.093190	0	0
ATP1A2	477	broad.mit.edu	37	1	160093040	160093040	+	Missense_Mutation	SNP	G	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr1:160093040G>T	uc001fvc.2	+	4	347	c.215G>T	c.(214-216)CGA>CTA	p.R72L	ATP1A2_uc001fvb.2_Missense_Mutation_p.R72L|ATP1A2_uc010piz.1_5'Flank	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	72	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GTTCTGGCTCGAGATGGGCCC	0.642000													16	101					4.7546e-09	5.02475e-09	0.146539	1	0
NCF2	4688	broad.mit.edu	37	1	183543623	183543623	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr1:183543623C>T	uc001gqj.3	-	4	775	c.500G>A	c.(499-501)TGG>TAG	p.W167*	NCF2_uc010pod.1_Intron|NCF2_uc010poe.1_Intron|NCF2_uc001gqk.3_Nonsense_Mutation_p.W167*	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	167					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding	p.W167C(1)		ovary(3)	3						TACGCTTACCCAGACACACTC	0.463000													139	157					0	0	0.139131	0	0
ESRRG	2104	broad.mit.edu	37	1	216824353	216824353	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr1:216824353C>T	uc001hkw.1	-	3	717	c.551G>A	c.(550-552)CGC>CAC	p.R184H	ESRRG_uc001hky.1_Missense_Mutation_p.R161H|ESRRG_uc009xdp.1_Missense_Mutation_p.R161H|ESRRG_uc001hkz.1_Intron|ESRRG_uc010puc.1_Missense_Mutation_p.R161H|ESRRG_uc001hla.1_Missense_Mutation_p.R161H|ESRRG_uc001hlb.1_Missense_Mutation_p.R161H|ESRRG_uc010pud.1_5'UTR|ESRRG_uc001hlc.1_Missense_Mutation_p.R161H|ESRRG_uc001hld.1_Missense_Mutation_p.R161H|ESRRG_uc001hkx.1_Missense_Mutation_p.R189H|ESRRG_uc009xdo.1_Missense_Mutation_p.R161H|ESRRG_uc001hle.1_Missense_Mutation_p.R161H	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	184	Nuclear receptor.|NR C4-type.				positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CTTCATGAAGCGGCAAGCCTG	0.448000													26	152					0	0	0.125774	0	0
SHOC2	8036	broad.mit.edu	37	10	112745430	112745430	+	Missense_Mutation	SNP	C	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr10:112745430C>A	uc001kzl.3	+	3	1097	c.748C>A	c.(748-750)CTT>ATT	p.L250I	SHOC2_uc009xxx.2_Missense_Mutation_p.L250I|SHOC2_uc010qrg.1_5'UTR|SHOC2_uc001kzn.2_Intron	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	250	LRR 7.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		TCACAATCAACTTGAACACCT	0.368000													9	91					0.000442599	0.000462491	0.058154	1	0
MRVI1	10335	broad.mit.edu	37	11	10615122	10615122	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr11:10615122C>T	uc010rcc.1	-	17	2478	c.2092G>A	c.(2092-2094)GTT>ATT	p.V698I	uc001miu.2_Intron|MRVI1_uc001miw.2_Missense_Mutation_p.V689I|MRVI1_uc010rcb.1_Missense_Mutation_p.V690I|MRVI1_uc009ygb.1_Missense_Mutation_p.V383I|MRVI1_uc001mix.2_Missense_Mutation_p.V383I|MRVI1_uc001miz.2_Missense_Mutation_p.V607I|MRVI1_uc009ygc.1_Missense_Mutation_p.V607I|MRVI1_uc010rcd.1_Missense_Mutation_p.V492I|MRVI1_uc009ygd.1_Missense_Mutation_p.V383I|MRVI1_uc010rce.1_RNA	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	671					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		ACCACAGCAACGCTGACCCTC	0.517000													30	29					0	0	0.116897	0	0
SART1	9092	broad.mit.edu	37	11	65733982	65733982	+	Silent	SNP	A	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr11:65733982A>G	uc001ogl.2	+	9	1235	c.1143A>G	c.(1141-1143)ACA>ACG	p.T381T	SART1_uc010rot.1_3'UTR	NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	381					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1						CCCTGAGCACAGTGGGGCCCC	0.677000													5	15					0	0	0.014758	0	0
ANKRD13D	338692	broad.mit.edu	37	11	67057909	67057909	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr11:67057909C>T	uc001okc.1	+	4	593	c.82C>T	c.(82-84)CTT>TTT	p.L28F	ANKRD13D_uc001okd.1_Missense_Mutation_p.L115F|ANKRD13D_uc001oke.1_Missense_Mutation_p.L28F	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	28										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCTCAACAAACTTCGCCAGGT	0.617000													2	4					0	0	0.115264	0	0
SAPS3	55291	broad.mit.edu	37	11	68355456	68355456	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr11:68355456A>G	uc001onw.2	+	16	1961	c.1694A>G	c.(1693-1695)AAC>AGC	p.N565S	SAPS3_uc001onv.2_Missense_Mutation_p.N565S|SAPS3_uc001ony.3_Missense_Mutation_p.N536S|SAPS3_uc001onx.2_Missense_Mutation_p.N559S|SAPS3_uc009ysh.2_Missense_Mutation_p.N485S|SAPS3_uc001onu.2_Missense_Mutation_p.N485S|SAPS3_uc010rqc.1_Missense_Mutation_p.N333S|SAPS3_uc010rqd.1_Missense_Mutation_p.N248S|SAPS3_uc001onz.2_5'UTR|SAPS3_uc001ooa.2_Missense_Mutation_p.N15S	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	565					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			TTTGGCTTCAACGATGAGAAG	0.428000													9	223					0	0	0.058154	0	0
DLG2	1740	broad.mit.edu	37	11	84996386	84996386	+	Missense_Mutation	SNP	T	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr11:84996386T>G	uc001pak.2	-	4	376	c.64A>C	c.(64-66)ACA>CCA	p.T22P		NM_001142699	NP_001136171	Q15700	DLG2_HUMAN	chapsyn-110 isoform 1	Error:Variant_position_missing_in_Q15700_after_alignment						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TTTAGCAATGTCACCTCATAA	0.348000													7	166					0	0	0.029380	0	0
HTR3A	3359	broad.mit.edu	37	11	113852031	113852031	+	Missense_Mutation	SNP	A	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr11:113852031A>T	uc010rxb.1	+	4	622	c.389A>T	c.(388-390)GAG>GTG	p.E130V	HTR3A_uc010rxa.1_Missense_Mutation_p.E130V|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Missense_Mutation_p.E109V	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	124	Extracellular (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	CTCATCAATGAGTTGTGAGTA	0.512000													23	32					0	0	0.076483	0	0
MIPEP	4285	broad.mit.edu	37	13	24411745	24411745	+	Missense_Mutation	SNP	T	C	C			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr13:24411745T>C	uc001uox.3	-	13	1589	c.1489A>G	c.(1489-1491)ATG>GTG	p.M497V		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	497					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		GCATGTCCCATTTCATGGAAA	0.438000													57	202					0	0	0.139131	0	0
FRY	10129	broad.mit.edu	37	13	32811758	32811758	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr13:32811758C>G	uc001utx.2	+	44	6549	c.6053C>G	c.(6052-6054)ACC>AGC	p.T2018S	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2018					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TCCTCAAAAACCAGAAGCTCA	0.537000													16	34					0	0	0.146539	0	0
NBEA	26960	broad.mit.edu	37	13	35923243	35923243	+	Splice_Site	SNP	A	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr13:35923243A>G	uc001uvb.2	+	37	6110	c.5904_splice	c.e37-2	p.R1968_splice	NBEA_uc010abi.2_Splice_Site_p.R624_splice	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin							cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TTTTCTTTTTAGATTACTGTG	0.313000													16	40					0	0	0.146539	0	0
TRPC4	7223	broad.mit.edu	37	13	38320234	38320234	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr13:38320234C>T	uc001uws.2	-	3	972	c.737G>A	c.(736-738)CGG>CAG	p.R246Q	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.R246Q|TRPC4_uc010tey.1_Missense_Mutation_p.R246Q|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Missense_Mutation_p.R246Q|TRPC4_uc010aby.2_Missense_Mutation_p.R246Q	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	246	Potential.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTTGCACTGCCGTGACAGCTC	0.423000													18	284					0	0	0.062417	0	0
MYH7	4625	broad.mit.edu	37	14	23884933	23884933	+	Silent	SNP	A	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr14:23884933A>G	uc001wjx.2	-	35	5168	c.5062T>C	c.(5062-5064)TTG>CTG	p.L1688L		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1688	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ACGGCACGCAACTCCTCCAGC	0.622000													3	55					0	0	0.115264	0	0
TJP1	7082	broad.mit.edu	37	15	30024898	30024898	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr15:30024898C>T	uc001zcr.2	-	14	2333	c.1858G>A	c.(1858-1860)GAT>AAT	p.D620N	TJP1_uc010azl.2_Missense_Mutation_p.D608N|TJP1_uc001zcq.2_Missense_Mutation_p.D624N|TJP1_uc001zcs.2_Missense_Mutation_p.D620N	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	620	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GCGGACAAATCCTCTCTGCTT	0.433000													46	95					0	0	0.139131	0	0
FSIP1	161835	broad.mit.edu	37	15	39910063	39910063	+	Silent	SNP	C	T	T	rs144527032	byFrequency	TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr15:39910063C>T	uc001zki.2	-	11	1790	c.1572G>A	c.(1570-1572)TCG>TCA	p.S524S		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	524										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		CAAGAGTCTTCGACATAAAAT	0.398000													84	51					0	0	0.139131	0	0
ZNF592	9640	broad.mit.edu	37	15	85326612	85326612	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr15:85326612C>T	uc002bld.2	+	4	1042	c.706C>T	c.(706-708)CGA>TGA	p.R236*	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	236					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGATGCCACTCGATTCTTCGG	0.567000													26	99					0	0	0.099896	0	0
CIITA	4261	broad.mit.edu	37	16	10997737	10997737	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr16:10997737C>T	uc002dai.3	+	9	1055	c.922C>T	c.(922-924)CGA>TGA	p.R308*	CIITA_uc002daj.3_Nonsense_Mutation_p.R309*|CIITA_uc002dak.3_Nonsense_Mutation_p.R259*|CIITA_uc002dag.2_Nonsense_Mutation_p.R308*|CIITA_uc002dah.2_Nonsense_Mutation_p.R260*|CIITA_uc010bup.1_Nonsense_Mutation_p.R308*	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	308					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CCTGACCTCCCGAGCAAACAT	0.592000			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								30	99					0	0	0.059317	0	0
ITGAL	3683	broad.mit.edu	37	16	30530025	30530025	+	Silent	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr16:30530025C>T	uc002dyi.3	+	29	3389	c.3213C>T	c.(3211-3213)AAC>AAT	p.N1071N	ITGAL_uc002dyj.3_Silent_p.N987N|ITGAL_uc010vev.1_Silent_p.N305N	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	1071	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	ATGGCAGCAACGCCTCCCTGG	0.612000													12	45					0	0	0.105934	0	0
METT10D	79066	broad.mit.edu	37	17	2376905	2376905	+	Missense_Mutation	SNP	A	C	C			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr17:2376905A>C	uc002fut.2	-	4	530	c.382T>G	c.(382-384)TAT>GAT	p.Y128D	METT10D_uc002fuu.3_RNA|METT10D_uc010cka.2_RNA|METT10D_uc002fuv.2_Missense_Mutation_p.Y128D|METT10D_uc010vqx.1_RNA|METT10D_uc010vqy.1_Intron	NM_024086	NP_076991	Q86W50	MET16_HUMAN	methyltransferase 10 domain containing	128							methyltransferase activity				0						GCGAGGAAATACCAGCCATTC	0.403000													8	41					0	0	0.080422	0	0
TRPV3	162514	broad.mit.edu	37	17	3458040	3458040	+	Silent	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr17:3458040G>A	uc002fvt.1	-	2	427	c.105C>T	c.(103-105)ACC>ACT	p.T35T	TRPV3_uc010vrj.1_5'UTR|TRPV3_uc010vrk.1_RNA|TRPV3_uc002fvr.2_Silent_p.T35T|TRPV3_uc002fvu.2_Silent_p.T35T	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	35	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	TCTTTGTGGGGGTGATCTCCG	0.657000													25	25					0	0	0.054565	0	0
ABHD15	116236	broad.mit.edu	37	17	27893210	27893210	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr17:27893210C>T	uc002hed.1	-	1	839	c.775G>A	c.(775-777)GCC>ACC	p.A259T	TP53I13_uc002hee.2_5'Flank	NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	259						extracellular region	carboxylesterase activity				0						ATGCAGGCGGCGCCTGTCACG	0.711000													9	3					0	0	0.132662	0	0
ABCC3	8714	broad.mit.edu	37	17	48741328	48741328	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr17:48741328C>G	uc002isl.2	+	10	1274	c.1194C>G	c.(1192-1194)AAC>AAG	p.N398K	ABCC3_uc002isk.3_Missense_Mutation_p.N398K|ABCC3_uc002ism.2_Missense_Mutation_p.L111V	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	398	Cytoplasmic (By similarity).|ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TTATCACCAACTCAGTCAAAC	0.587000													8	90					0	0	0.047766	0	0
ATP8B3	148229	broad.mit.edu	37	19	1785266	1785266	+	Silent	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr19:1785266G>A	uc002ltw.2	-	27	3658	c.3424C>T	c.(3424-3426)CTG>TTG	p.L1142L	ATP8B3_uc002ltv.2_Silent_p.L1105L|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1142	Helical; (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCACGCACAGGGCGGTCCAG	0.607000													3	14					0	0	0.009096	0	0
SAFB2	9667	broad.mit.edu	37	19	5587939	5587939	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr19:5587939G>A	uc002mcd.2	-	19	2790	c.2578C>T	c.(2578-2580)CGC>TGC	p.R860C		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	860	Interacts with SAFB1.|Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TGCCAGGCGCGTGCCTGGTGC	0.662000													4	12					0	0	0.014758	0	0
MAG	4099	broad.mit.edu	37	19	35802842	35802842	+	Silent	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr19:35802842C>T	uc002nyy.1	+	10	1787	c.1638C>T	c.(1636-1638)CCC>CCT	p.P546P	MAG_uc002nyx.1_Silent_p.P546P|MAG_uc010eds.1_Silent_p.P521P|MAG_uc002nyz.1_Silent_p.P546P	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	546	Cytoplasmic (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CAGAGAGCCCCAGCTTCTCGG	0.607000													11	1					0	0	0.132662	0	0
ZNF546	339327	broad.mit.edu	37	19	40520711	40520711	+	Missense_Mutation	SNP	C	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr19:40520711C>G	uc002oms.2	+	7	1790	c.1534C>G	c.(1534-1536)CTC>GTC	p.L512V	ZNF546_uc002omt.2_Missense_Mutation_p.L486V	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	512	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCGCTATCATCTCACTCAACA	0.403000													41	16					0	0	0.111260	0	0
SLC17A7	57030	broad.mit.edu	37	19	49933845	49933845	+	Silent	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr19:49933845C>T	uc002pnp.2	-	12	1786	c.1614G>A	c.(1612-1614)CCG>CCA	p.P538P	SLC17A7_uc002pno.2_Silent_p.P200P	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	538	Cytoplasmic (Potential).|Pro-rich.				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		CATAGGAGGGCGGGGGTGCAG	0.647000													9	8					0	0	0.058154	0	0
REG3G	130120	broad.mit.edu	37	2	79253917	79253917	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr2:79253917A>G	uc002snw.2	+	3	240	c.155A>G	c.(154-156)TAT>TGT	p.Y52C	REG3G_uc002snx.2_Missense_Mutation_p.Y52C|REG3G_uc010ffu.2_Missense_Mutation_p.Y52C	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	52	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TCCCCCTGCTATGCCTTGTTT	0.542000													13	22					0	0	0.119110	0	0
Unknown	0	broad.mit.edu	37	2	96521777	96521777	+	Missense_Mutation	SNP	T	C	C	rs77768218		TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr2:96521777T>C	uc002suz.1	-	31	2790	c.1313A>G	c.(1312-1314)CAT>CGT	p.H438R						SubName: Full=Putative uncharacterized protein ENSP00000312008; Flags: Fragment;																		AAGGTCTTCATGCTTTCTTTT	0.383000													3	44					0	0	0.115264	0	0
SPOPL	339745	broad.mit.edu	37	2	139308482	139308482	+	Silent	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr2:139308482G>A	uc002tvh.2	+	4	610	c.210G>A	c.(208-210)AGG>AGA	p.R70R		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	70	MATH.					nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GGTGCCTGAGGGTAAACCCAA	0.294000													35	153					0	0	0.064281	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								60	67					0	0	0.139131	0	0
CYP24A1	1591	broad.mit.edu	37	20	52779339	52779339	+	Missense_Mutation	SNP	A	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr20:52779339A>T	uc002xwv.2	-	7	1305	c.907T>A	c.(907-909)TGT>AGT	p.C303S	CYP24A1_uc002xwu.1_Missense_Mutation_p.C161S|CYP24A1_uc002xww.2_Missense_Mutation_p.C303S	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	303					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	TAAATGTCACAAAGGAAATCT	0.463000													52	55					0	0	0.139131	0	0
STMN3	50861	broad.mit.edu	37	20	62272736	62272736	+	Silent	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr20:62272736G>A	uc002yfr.1	-	5	580	c.498C>T	c.(496-498)GCC>GCT	p.A166A	STMN3_uc011abb.1_Silent_p.A166A	NM_015894	NP_056978	Q9NZ72	STMN3_HUMAN	SCG10-like-protein	166	Potential.				cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding				0	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			TGCGCACCTCGGCCGCGTGCA	0.716000													5	3					0	0	0.014758	0	0
TPST2	8459	broad.mit.edu	37	22	26937282	26937282	+	Silent	SNP	G	A	A	rs146078388	byFrequency	TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr22:26937282G>A	uc003acv.2	-	2	483	c.315C>T	c.(313-315)CGC>CGT	p.R105R	TPST2_uc003acw.2_Silent_p.R105R|TPST2_uc003acx.2_Silent_p.R105R|TPST2_uc011akf.1_Silent_p.R105R	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	105	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						TGGCCAGCACGCGCGGGATGA	0.706000													7	25					0	0	0.038147	0	0
MICALL1	85377	broad.mit.edu	37	22	38323452	38323452	+	Silent	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr22:38323452G>A	uc003aui.2	+	9	1584	c.1500G>A	c.(1498-1500)CCG>CCA	p.P500P		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	500	Pro-rich.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					ACTCGGAGCCGCCCTCGGCCA	0.687000													11	15					0	0	0.093190	0	0
SUMF1	285362	broad.mit.edu	37	3	4491010	4491010	+	Silent	SNP	G	A	A	rs148557574		TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr3:4491010G>A	uc003bpz.1	-	3	484	c.459C>T	c.(457-459)GGC>GGT	p.G153G	SUMF1_uc003bps.1_RNA|SUMF1_uc011ass.1_Intron|SUMF1_uc010hby.1_Silent_p.G153G|SUMF1_uc011ast.1_Intron	NM_182760	NP_877437	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1 isoform 1	153						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		CAAAGGAGTCGCCAAACTTCT	0.403000													104	145					0	0	0.139131	0	0
RBM6	10180	broad.mit.edu	37	3	50099412	50099412	+	Silent	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr3:50099412C>T	uc003cyc.2	+	15	2590	c.2457C>T	c.(2455-2457)CCC>CCT	p.P819P	RBM6_uc010hlc.1_Silent_p.P338P|RBM6_uc003cyd.2_Silent_p.P297P|RBM6_uc003cye.2_Silent_p.P297P|RBM6_uc011bdi.1_Silent_p.P161P|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	819					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		TCTATGTGCCCCAGGATCCTG	0.438000													20	41					0	0	0.043863	0	0
MCCC1	56922	broad.mit.edu	37	3	182759530	182759530	+	Silent	SNP	T	C	C			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr3:182759530T>C	uc003fle.2	-	11	1229	c.1092A>G	c.(1090-1092)GCA>GCG	p.A364A	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Silent_p.A247A|MCCC1_uc003flg.2_Silent_p.A255A|MCCC1_uc011bqp.1_Silent_p.A317A	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	364	Biotin carboxylation.|ATP-grasp.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	TCTTCTCTCCTGCTGCAATCT	0.403000													82	120					0	0	0.139131	0	0
SDHAP2	727956	broad.mit.edu	37	3	195400728	195400728	+	Silent	SNP	A	G	G	rs12107841	by1000genomes	TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr3:195400728A>G	uc003fuw.2	+	9	1218	c.24A>G	c.(22-24)CCA>CCG	p.P8P	SDHAP2_uc011btb.1_Missense_Mutation_p.S156G|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GATTGTGCCCAGCCTGTACGC	0.587000													7	39					0	0	0.029380	0	0
LRCH3	84859	broad.mit.edu	37	3	197559180	197559180	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr3:197559180A>G	uc011bul.1	+	8	1099	c.1094A>G	c.(1093-1095)AAC>AGC	p.N365S	LRCH3_uc003fyj.1_Missense_Mutation_p.N365S|LRCH3_uc011bum.1_Missense_Mutation_p.N365S|LRCH3_uc011bun.1_Missense_Mutation_p.N239S|LRCH3_uc003fyk.2_5'UTR	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	365						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		GTAGTAACAAACGGCGGAGGT	0.408000													17	57					0	0	0.033300	0	0
KIAA1109	84162	broad.mit.edu	37	4	123192264	123192264	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr4:123192264G>A	uc003ieh.2	+	45	7630	c.7585G>A	c.(7585-7587)GTG>ATG	p.V2529M	KIAA1109_uc003iel.1_Missense_Mutation_p.V464M|KIAA1109_uc003iek.2_Missense_Mutation_p.V1148M	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2529					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GGAAAAGTCCGTGTGCACCCC	0.438000													52	143					0	0	0.139131	0	0
PIK3R1	5295	broad.mit.edu	37	5	67589138	67589138	+	Missense_Mutation	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr5:67589138G>A	uc003jva.2	+	10	1686	c.1126G>A	c.(1126-1128)GGA>AGA	p.G376R	PIK3R1_uc003jvb.2_Missense_Mutation_p.G376R|PIK3R1_uc003jvc.2_Missense_Mutation_p.G76R|PIK3R1_uc003jvd.2_Missense_Mutation_p.G106R|PIK3R1_uc003jve.2_Missense_Mutation_p.G55R|PIK3R1_uc011crb.1_Missense_Mutation_p.G46R	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	376	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.G376R(3)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CAGGAAAGGGGGAAATAACAA	0.308000			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			40	70					0	0	0.104719	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79854586	79854586	+	Missense_Mutation	SNP	G	A	A	rs149831177		TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr5:79854586G>A	uc010jam.2	-	4	1603	c.1253C>T	c.(1252-1254)CCC>CTC	p.P418L	ANKRD34B_uc003kgw.2_Missense_Mutation_p.P418L|ANKRD34B_uc010jan.2_Missense_Mutation_p.P418L	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	418						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		CCTGCTCAGGGGACCTGGGGG	0.473000													10	195					0	0	0.058154	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481839	140481839	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr5:140481839C>T	uc003lio.2	+	1	1606	c.1606C>T	c.(1606-1608)CGT>TGT	p.R536C	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	536	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCCACAGACCGTGGCTCCCC	0.672000													17	55					0	0	0.055883	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711827	140711827	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr5:140711827C>T	uc003lji.1	+	1	1576	c.1576C>T	c.(1576-1578)CGG>TGG	p.R526W	PCDHGA1_uc011dan.1_Missense_Mutation_p.R526W	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	526	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGCAGTTCCGGGACATGCA	0.587000													72	255					0	0	0.139131	0	0
GRPEL2	134266	broad.mit.edu	37	5	148727842	148727842	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr5:148727842C>T	uc003lqj.2	+	2	211	c.85C>T	c.(85-87)CCG>TCG	p.P29S	GRPEL2_uc011dca.1_Missense_Mutation_p.P29S	NM_152407	NP_689620	Q8TAA5	GRPE2_HUMAN	GrpE-like 2, mitochondrial precursor	29					protein folding	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGGGGATGGCCGCTTCCATT	0.517000													28	105					0	0	0.144211	0	0
NEDD9	4739	broad.mit.edu	37	6	11190997	11190997	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr6:11190997A>G	uc003mzv.2	-	5	1272	c.1105T>C	c.(1105-1107)TCT>CCT	p.S369P	NEDD9_uc010joz.2_Missense_Mutation_p.S369P|NEDD9_uc003mzw.3_Missense_Mutation_p.S223P	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	369					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			CTGGAGAAAGACAATCGGTTG	0.547000													55	49					0	0	0.139131	0	0
GPX6	257202	broad.mit.edu	37	6	28472105	28472105	+	Silent	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr6:28472105G>A	uc011dlj.1	-	6	680	c.630C>T	c.(628-630)GAC>GAT	p.D210D	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	210					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	ACTCCAGGATGTCTGACTTGA	0.502000													59	71					0	0	0.139131	0	0
ABCC10	89845	broad.mit.edu	37	6	43400462	43400462	+	Silent	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr6:43400462C>T	uc003ouy.1	+	3	959	c.744C>T	c.(742-744)TGC>TGT	p.C248C	ABCC10_uc003ouz.1_Silent_p.C205C	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	248						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			AGGACATTTGCCGCCTCCCCC	0.642000													3	35					0	0	0.009096	0	0
PAQR8	85315	broad.mit.edu	37	6	52268301	52268301	+	Missense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr6:52268301C>T	uc003pao.3	+	2	464	c.290C>T	c.(289-291)GCC>GTC	p.A97V		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	97	Extracellular (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					TGGGCCTTTGCCGAGGCTGAG	0.572000													15	66					0	0	0.033300	0	0
SIM1	6492	broad.mit.edu	37	6	100841631	100841631	+	Silent	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr6:100841631G>A	uc003pqj.3	-	10	1509	c.1302C>T	c.(1300-1302)TGC>TGT	p.C434C	SIM1_uc010kcu.2_Silent_p.C434C	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	434	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GTCTGTAGGCGCACGATGCGT	0.617000													19	65					0	0	0.055883	0	0
SLA	6503	broad.mit.edu	37	8	134050855	134050855	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr8:134050855G>A	uc003ytz.2	-	9	1577	c.745C>T	c.(745-747)CGA>TGA	p.R249*	TG_uc003ytw.2_Intron|TG_uc010mdw.2_Intron|TG_uc011ljb.1_Intron|TG_uc011ljc.1_Intron|SLA_uc011lje.1_Nonsense_Mutation_p.R266*|SLA_uc011ljf.1_Nonsense_Mutation_p.R141*|SLA_uc011ljg.1_Nonsense_Mutation_p.R222*|SLA_uc011ljd.1_Nonsense_Mutation_p.R289*	NM_001045556	NP_001039021	Q13239	SLAP1_HUMAN	Src-like-adaptor isoform a	249	SLA C-terminal.					endosome	SH3/SH2 adaptor activity			lung(1)|liver(1)	2	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			TTCTTCTTTCGATCAAAGGAG	0.498000													61	196					0	0	0.139131	0	0
JAK2	3717	broad.mit.edu	37	9	5090496	5090496	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr9:5090496C>T	uc010mhm.2	+	20	2925	c.2812C>T	c.(2812-2814)CGA>TGA	p.R938*	JAK2_uc003ziw.2_Nonsense_Mutation_p.R938*	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	938	Protein kinase 2.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TGGAAGTTTACGAGACTATCT	0.313000		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				103	21					0	0	0.139131	0	0
FREM1	158326	broad.mit.edu	37	9	14841479	14841479	+	Missense_Mutation	SNP	T	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr9:14841479T>G	uc003zlm.2	-	10	2437	c.1847A>C	c.(1846-1848)GAC>GCC	p.D616A	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	616	CSPG 3.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TTCATGGCTGTCCCACAGGAC	0.313000													8	42					0	0	0.069234	0	0
LOC442421	442421	broad.mit.edu	37	9	66500810	66500810	+	RNA	SNP	G	A	A	rs142815546	by1000genomes	TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr9:66500810G>A	uc004aed.1	+	3		c.903G>A								Homo sapiens similar to prostaglandin E receptor 4, subtype EP4; PGE receptor, EP4 subtype; prostaglandin E2 receptor, mRNA (cDNA clone IMAGE:5288780).												0						ACCTACGGTCGGTTGTGTGCA	0.637000													8	18					0	0	0.038147	0	0
CKS2	1164	broad.mit.edu	37	9	91926227	91926227	+	Missense_Mutation	SNP	A	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr9:91926227A>G	uc004aqh.2	+	1	115	c.20A>G	c.(19-21)TAC>TGC	p.Y7C	hsa-mir-3153|MI0014180_5'Flank	NM_001827	NP_001818	P33552	CKS2_HUMAN	CDC28 protein kinase 2	7					cell division|cell proliferation|phosphatidylinositol-mediated signaling|regulation of cyclin-dependent protein kinase activity|spindle organization		cyclin-dependent protein kinase regulator activity				0						AAGCAGATCTACTACTCGGAC	0.522000													14	17					0	0	0.132662	0	0
RPL7A	6130	broad.mit.edu	37	9	136217156	136217156	+	Silent	SNP	C	T	T	rs142456845	by1000genomes	TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr9:136217156C>T	uc004cde.1	+	5	507	c.477C>T	c.(475-477)CAC>CAT	p.H159H	MED22_uc004cdc.2_5'Flank|MED22_uc004cdd.2_5'Flank|RPL7A_uc004cdf.1_Translation_Start_Site|SNORD36A_uc010naj.2_5'Flank|SNORD36C_uc010nak.2_5'Flank	NM_000972	NP_000963	P62424	RL7A_HUMAN	ribosomal protein L7a	159					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|membrane fraction|polysomal ribosome	RNA binding|structural constituent of ribosome				0				OV - Ovarian serous cystadenocarcinoma(145;4.93e-07)|Epithelial(140;4.09e-06)|all cancers(34;3.78e-05)		TGATTGCACACGACGTGGATC	0.522000													9	35					0	0	0.058154	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995929	140995929	+	Silent	SNP	C	T	T			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chrX:140995929C>T	uc004fbt.2	+	4	3025	c.2739C>T	c.(2737-2739)GAC>GAT	p.D913D	MAGEC1_uc010nsl.1_Translation_Start_Site	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	913	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AAAAGGTGGACGAGTTGGCGC	0.488000										HNSCC(15;0.026)			12	182					0	0	0.080935	0	0
NCKAP5	344148	broad.mit.edu	37	2	133486435	133486436	+	Frame_Shift_Ins	INS	-	G	G			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr2:133486435_133486436insG	uc002ttp.2	-	18	5907_5908	c.5533_5534insC	c.(5533-5535)CAGfs	p.Q1845fs	NCKAP5_uc002ttq.2_Frame_Shift_Ins_p.Q526fs	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1845							protein binding				0						TGGAAGCGGCTGGCTTGCCATT	0.545													9	355	---	---	---	---					
ZCCHC9	84240	broad.mit.edu	37	5	80607067	80607070	+	Frame_Shift_Del	DEL	AAAG	-	-			TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr5:80607067_80607070delAAAG	uc003khj.2	+	5	799_802	c.666_669delAAAG	c.(664-669)TTAAAGfs	p.L222fs	RNU5E_uc011cto.1_Intron|ZCCHC9_uc003khk.3_Frame_Shift_Del_p.L222fs|ZCCHC9_uc003khi.2_Frame_Shift_Del_p.L222fs	NM_001131035	NP_001124507	Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	222_223	CCHC-type 4.						nucleic acid binding|zinc ion binding			ovary(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		TGGAACATTTAAAGAAAGATTGCC	0.348													190	349	---	---	---	---					
TMCO6	55374	broad.mit.edu	37	5	140024213	140024214	+	Frame_Shift_Ins	INS	-	G	G	rs4147626		TCGA-DB-5279-01A-01D-1468-08	TCGA-DB-5279-10A-01D-1468-08									Somatic	Phase_I	Capture				Illumina GAIIx	277aa1d8-ce6a-4e32-a267-73c33665ab97	1761720c-3e2f-4ce7-8551-b859117e150f	g.chr5:140024213_140024214insG	uc003lgl.2	+	11	1357_1358	c.1256_1257insG	c.(1255-1257)CTGfs	p.L419fs	TMCO6_uc003lgm.2_Frame_Shift_Ins_p.L425fs|TMCO6_uc010jft.2_Frame_Shift_Ins_p.L179fs|TMCO6_uc003lgn.2_Frame_Shift_Ins_p.L310fs|TMCO6_uc003lgo.2_Frame_Shift_Ins_p.L179fs	NM_018502	NP_060972	Q96DC7	TMCO6_HUMAN	transmembrane and coiled-coil domains 6	419					protein import into nucleus	cytoplasm|nuclear pore	binding|protein transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCAGCGGCTGTGGCCAGGGC	0.510													9	425	---	---	---	---					
