Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
EIF4G3	8672	broad.mit.edu	37	1	21133862	21133862	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr1:21133862C>T	uc001bec.2	-	32	4964	c.4708G>A	c.(4708-4710)GCA>ACA	p.A1570T	EIF4G3_uc010odi.1_Missense_Mutation_p.A1174T|EIF4G3_uc010odj.1_Missense_Mutation_p.A1569T|EIF4G3_uc009vpz.2_Missense_Mutation_p.A1290T|EIF4G3_uc001bed.2_Missense_Mutation_p.A1570T|EIF4G3_uc001bef.2_Missense_Mutation_p.A1606T|EIF4G3_uc001bee.2_Missense_Mutation_p.A1576T	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1570	EIF4A-binding (By similarity).|W2.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GTGAAGAATGCCGTGACAGAT	0.453000													5	326					0	0	0.000602	0	0
KIAA0467	23334	broad.mit.edu	37	1	43912025	43912025	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr1:43912025T>C	uc001cjk.1	+	50	6775	c.6313T>C	c.(6313-6315)TGT>CGT	p.C2105R	KIAA0467_uc001cjl.1_Missense_Mutation_p.C93R	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	3004						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGTTACTTCTGTGTCAAACA	0.552000													4	102					0	0	0.000602	0	0
PGM1	5236	broad.mit.edu	37	1	64100510	64100510	+	Silent	SNP	G	A	A			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr1:64100510G>A	uc001dbh.2	+	5	906	c.693G>A	c.(691-693)CCG>CCA	p.P231P	PGM1_uc010ooy.1_Silent_p.P34P|PGM1_uc010ooz.1_Silent_p.P249P	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	231					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						TTGTGGGACCGTATGTAAAGA	0.473000													4	144					0	0	0.000248	0	0
RPTN	126638	broad.mit.edu	37	1	152128682	152128682	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr1:152128682G>A	uc001ezs.1	-	3	958	c.893C>T	c.(892-894)ACG>ATG	p.T298M		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	298	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TTGTCTGTCCGTCTGACCGTA	0.512000													81	809					0	0	0.003610	0	0
DCST1	149095	broad.mit.edu	37	1	155013046	155013046	+	Silent	SNP	C	T	T	rs141235792		TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr1:155013046C>T	uc001fgn.1	+	6	573	c.477C>T	c.(475-477)CGC>CGT	p.R159R	DCST1_uc010per.1_Silent_p.R184R|DCST1_uc010pes.1_Silent_p.R134R	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	159	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			ACAACACCCGCGCAGCTTGGC	0.617000													4	9					0	0	0.000248	0	0
FAM178A	55719	broad.mit.edu	37	10	102683830	102683830	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr10:102683830G>C	uc001krt.3	+	5	1614	c.1072G>C	c.(1072-1074)GAG>CAG	p.E358Q	FAM178A_uc001krr.1_Missense_Mutation_p.E358Q|FAM178A_uc001krs.2_Missense_Mutation_p.E358Q|FAM178A_uc001kru.1_Missense_Mutation_p.E293Q	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	358											0						AAAAGCAAGAGAGTCCTTCCT	0.398000													5	46					0	0	0.001168	0	0
UCP3	7352	broad.mit.edu	37	11	73714925	73714925	+	Silent	SNP	G	A	A			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr11:73714925G>A	uc001our.2	-	6	1126	c.771C>T	c.(769-771)CTC>CTT	p.L257L	UCP3_uc001ous.2_Silent_p.L257L	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	257	Solcar 3.				mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)					TCATACAGTCGAGGGGGCTGA	0.617000													8	194					0	0	0.004482	0	0
MLL	4297	broad.mit.edu	37	11	118344301	118344301	+	Silent	SNP	T	A	A			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr11:118344301T>A	uc001pta.2	+	3	2450	c.2427T>A	c.(2425-2427)TCT>TCA	p.S809S	MLL_uc001ptb.2_Silent_p.S809S|MLL_uc001psz.1_Silent_p.S842S|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	809					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CTGGGGAATCTGCAGAGAAAA	0.468000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								7	167					0	0	0.003080	0	0
KRT8	3856	broad.mit.edu	37	12	53293635	53293635	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr12:53293635C>T	uc001sbd.2	-	5	1008	c.905G>A	c.(904-906)CGC>CAC	p.R302H	KRT8_uc009zmj.2_Missense_Mutation_p.R302H|KRT8_uc009zmk.1_Missense_Mutation_p.R330H|KRT8_uc009zml.1_Missense_Mutation_p.R302H|KRT8_uc009zmm.1_Missense_Mutation_p.R302H	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	302	Necessary for interaction with PNN.|Rod.|Coil 2.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTCTTTGTGCGCCGCAGGTC	0.602000													30	35					0	0	0.007291	0	0
ATP5B	506	broad.mit.edu	37	12	57036472	57036472	+	Silent	SNP	G	C	C			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr12:57036472G>C	uc001slr.2	-	6	1041	c.936C>G	c.(934-936)ACC>ACG	p.T312T		NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	312					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						AACCAGCCTGGGTGAAGCGAA	0.483000													25	67					0	0	0.006320	0	0
SLC5A8	160728	broad.mit.edu	37	12	101577979	101577979	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr12:101577979C>A	uc001thz.3	-	8	1375	c.985G>T	c.(985-987)GAC>TAC	p.D329Y		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	329	Extracellular (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						TGCAGAATGTCCAGTACCAAA	0.348000													9	48					0.000442599	0.000569056	0.006214	1	0
SERPINA9	327657	broad.mit.edu	37	14	94929626	94929626	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr14:94929626T>A	uc001ydf.2	-	5	1273	c.1112A>T	c.(1111-1113)CAC>CTC	p.H371L	SERPINA9_uc001yde.2_Missense_Mutation_p.H271L|SERPINA9_uc010avc.2_Missense_Mutation_p.H222L|SERPINA9_uc001ydg.2_Missense_Mutation_p.H335L	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	353					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CACAGCCTTGTGGGTTGCCTG	0.502000													14	75					0	0	0.003163	0	0
Unknown	0	broad.mit.edu	37	15	28929385	28929385	+	RNA	SNP	T	C	C	rs692172	by1000genomes	TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr15:28929385T>C	uc010azc.2	+	14		c.2090T>C								Homo sapiens I.M.A.G.E. clone 321824, mRNA sequence.																		CACGCTGCGGTGGTCTTGCAT	0.453000													4	54					0	0	0.000248	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			33	4					0	0	0.002096	0	0
Unknown	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	G	G	rs149119138	by1000genomes	TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr17:21731144T>G	uc002gyy.3	+	2	571	c.446T>G	c.(445-447)CTG>CGG	p.L149R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GTCCTGCGTCTGAGAGGTGGT	0.542000													4	128					0	0	0.000602	0	0
PIP4K2B	8396	broad.mit.edu	37	17	36926734	36926734	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr17:36926734A>C	uc002hqs.2	-	9	1606	c.1125T>G	c.(1123-1125)GAT>GAG	p.D375E	PIP4K2B_uc010cvp.2_5'Flank	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	375	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						TCTTCTTTGTATCGTATGGCG	0.537000													4	191					0	0	0.004482	0	0
CHAD	1101	broad.mit.edu	37	17	48543081	48543081	+	Missense_Mutation	SNP	G	A	A	rs138200891		TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr17:48543081G>A	uc010dbr.2	-	2	978	c.925C>T	c.(925-927)CGG>TGG	p.R309W	ACSF2_uc002iqu.2_Intron|ACSF2_uc010wml.1_Intron|ACSF2_uc010wmm.1_Intron|ACSF2_uc010wmn.1_Intron|ACSF2_uc010wmo.1_Intron|CHAD_uc010dbs.2_Missense_Mutation_p.R309W|ACSF2_uc010dbt.1_5'Flank	NM_001267	NP_001258	O15335	CHAD_HUMAN	chondroadherin precursor	309	LRRCT.				regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(2)|central_nervous_system(1)	3	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CGAAGGCCCCGGAGCTGGCAG	0.537000													4	196					0	0	0.000602	0	0
PSG7	5676	broad.mit.edu	37	19	43439742	43439742	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr19:43439742A>G	uc002ovl.3	-	2	346	c.244T>C	c.(244-246)TAT>CAT	p.Y82H	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	82	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TCTACTATATATGATGTAACA	0.418000													23	446					0	0	0.001882	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628865	51628865	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr19:51628865A>T	uc002pvu.2	+	2	500	c.433A>T	c.(433-435)AGG>TGG	p.R145W	SIGLEC9_uc010yct.1_Missense_Mutation_p.R145W	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	145	Extracellular (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CTTGACCCACAGGCCCAACAT	0.642000													5	221					0	0	0.001168	0	0
SEMA4F	10505	broad.mit.edu	37	2	74901749	74901749	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr2:74901749G>A	uc002sna.1	+	8	1058	c.947G>A	c.(946-948)CGA>CAA	p.R316Q	SEMA4F_uc010ffq.1_Missense_Mutation_p.R283Q|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Missense_Mutation_p.R161Q	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	316	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GCTGTGCTTCGACCTGAGCTT	0.562000													21	224					0	0	0.001882	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								38	45					0	0	0.002522	0	0
GIGYF2	26058	broad.mit.edu	37	2	233655736	233655736	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr2:233655736A>G	uc002vti.3	+	13	1286	c.949A>G	c.(949-951)ATT>GTT	p.I317V	GIGYF2_uc010zmj.1_Missense_Mutation_p.I317V|GIGYF2_uc002vtg.2_Missense_Mutation_p.I311V|GIGYF2_uc002vtj.3_Missense_Mutation_p.I339V|GIGYF2_uc002vtk.3_Missense_Mutation_p.I317V|GIGYF2_uc002vth.3_Missense_Mutation_p.I311V|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.I148V	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	317					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GAAAGAGCCTATTCCAGAAGA	0.443000													3	92					0	0	0.004672	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492966	21492966	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr20:21492966C>G	uc002wsi.2	-	2	774	c.417G>C	c.(415-417)CAG>CAC	p.Q139H		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	139	Homeobox.				brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						GCTCGTAGGTCTGCGCCTTGG	0.692000													16	26					0	0	0.006122	0	0
KCNB1	3745	broad.mit.edu	37	20	47989844	47989844	+	Silent	SNP	A	C	C			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr20:47989844A>C	uc002xur.1	-	2	2417	c.2253T>G	c.(2251-2253)GGT>GGG	p.G751G	KCNB1_uc002xus.1_Silent_p.G751G	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	751	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ACTGGTGGACACCCGCCTCAA	0.572000													17	184					0	0	0.003610	0	0
COL6A1	1291	broad.mit.edu	37	21	47409674	47409674	+	Silent	SNP	A	G	G			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr21:47409674A>G	uc002zhu.1	+	11	1014	c.912A>G	c.(910-912)AAA>AAG	p.K304K		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	304	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	AGGGAGAAAAAGGGAGCCGTG	0.637000													3	109					0	0	0.004672	0	0
PATZ1	23598	broad.mit.edu	37	22	31740738	31740738	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr22:31740738C>T	uc003akq.2	-	1	1512	c.851G>A	c.(850-852)GGG>GAG	p.G284E	PATZ1_uc003akp.2_Missense_Mutation_p.G284E|PATZ1_uc003akr.2_Missense_Mutation_p.G284E|PATZ1_uc003aks.2_Missense_Mutation_p.G284E|uc003akt.2_5'Flank	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	284					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						CCTCAGGCCCCCTGGGGACCC	0.652000													6	18					0	0	0.003080	0	0
SCN10A	6336	broad.mit.edu	37	3	38793869	38793869	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr3:38793869G>T	uc003ciq.2	-	11	1596	c.1596C>A	c.(1594-1596)AGC>AGA	p.S532R		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	532					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AGCCCCGATGGCTTTCGTGGT	0.602000													7	82					0.00198382	0.00249131	0.001984	1	0
CD200	4345	broad.mit.edu	37	3	112064083	112064083	+	Silent	SNP	C	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr3:112064083C>T	uc003dyw.2	+	4	588	c.444C>T	c.(442-444)TTC>TTT	p.F148F	CD200_uc010hqd.1_Missense_Mutation_p.S9L|CD200_uc003dyx.2_Silent_p.F123F|CD200_uc003dyy.2_Missense_Mutation_p.S9L|CD200_uc003dyz.2_Silent_p.F49F	NM_001004196	NP_001004196	P41217	OX2G_HUMAN	CD200 antigen isoform b	123	Ig-like V-type.|Extracellular (Potential).				regulation of immune response	integral to plasma membrane					0		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				TGTGTCTCTTCAATACCTTTG	0.443000													4	125					0	0	0.000248	0	0
KIT	3815	broad.mit.edu	37	4	55561801	55561801	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr4:55561801T>G	uc010igr.2	+	2	278	c.191T>G	c.(190-192)GTC>GGC	p.V64G	KIT_uc010igs.2_Missense_Mutation_p.V64G	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	64	Extracellular (Potential).|Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCGGGCTTTGTCAAATGGACT	0.493000		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				4	78					0	0	0.000248	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730818	140730818	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr5:140730818A>G	uc003ljo.1	+	1	991	c.991A>G	c.(991-993)ATA>GTA	p.I331V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.I331V	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	331	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAATGTTCAAATAGAAATTGT	0.428000													6	76					0	0	0.001984	0	0
GPR31	2853	broad.mit.edu	37	6	167570606	167570606	+	Silent	SNP	G	A	A			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr6:167570606G>A	uc011egq.1	-	1	714	c.714C>T	c.(712-714)TGC>TGT	p.C238C		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	238	Helical; Name=6; (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		TGGCCAGGAAGCAGGGCAGAA	0.592000													11	118					0	0	0.000978	0	0
UNC93A	54346	broad.mit.edu	37	6	167717405	167717405	+	Splice_Site	SNP	A	G	G			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr6:167717405A>G	uc003qvq.2	+	5	801	c.626_splice	c.e5-2	p.G209_splice	UNC93A_uc003qvr.2_Splice_Site_p.G167_splice	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1							integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ATGTCCTTTCAGGGAGTGGTG	0.483000													27	105					0	0	0.002836	0	0
MUC17	140453	broad.mit.edu	37	7	100681682	100681682	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr7:100681682C>T	uc003uxp.1	+	3	7038	c.6985C>T	c.(6985-6987)CCA>TCA	p.P2329S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2329	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|37.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCAACCTCAAC	0.478000													6	586					0	0	0.001984	0	0
NOS3	4846	broad.mit.edu	37	7	150693876	150693876	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr7:150693876C>T	uc003wif.2	+	5	741	c.445C>T	c.(445-447)CGG>TGG	p.R149W	NOS3_uc011kuy.1_Intron|NOS3_uc011kuz.1_Missense_Mutation_p.R149W|NOS3_uc011kva.1_Missense_Mutation_p.R149W|NOS3_uc011kvb.1_Missense_Mutation_p.R149W	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	149	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCACGAACAGCGGCTTCAAGA	0.657000													6	23					0	0	0.006214	0	0
MLL3	58508	broad.mit.edu	37	7	151842271	151842271	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr7:151842271T>G	uc003wla.2	-	54	14360	c.14141A>C	c.(14140-14142)AAA>ACA	p.K4714T	MLL3_uc003wkz.2_Missense_Mutation_p.K3832T|MLL3_uc003wkx.2_Missense_Mutation_p.K872T|MLL3_uc003wky.2_Missense_Mutation_p.K2278T	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4714					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGCACTCATTTTAGGTTCAGA	0.448000			N		medulloblastoma								16	117					0	0	0.004990	0	0
KIAA1429	25962	broad.mit.edu	37	8	95523837	95523837	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr8:95523837A>G	uc003ygo.1	-	13	2979	c.2966T>C	c.(2965-2967)CTC>CCC	p.L989P	KIAA1429_uc003ygp.2_Missense_Mutation_p.L989P|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	989					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GTTGACATGGAGCCTCCAAGG	0.428000													3	111					0	0	0.004672	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070935	141070935	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr9:141070935C>T	uc004com.2	+	4	599	c.338C>T	c.(337-339)GCC>GTC	p.A113V	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						CCCTACAACGCCACCCTCTCA	0.517000													4	90					0	0	0.000602	0	0
ATRX	546	broad.mit.edu	37	X	76845411	76845411	+	Splice_Site	SNP	C	T	T			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chrX:76845411C>T	uc004ecp.3	-	27	6343	c.6111_splice	c.e27-1	p.V2037_splice	ATRX_uc004ecq.3_Splice_Site_p.V1999_splice|ATRX_uc004eco.3_Splice_Site_p.V1822_splice	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1						DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GAAAACAAGGCTAAAAAAACA	0.204000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						23	6					0	0	0.001882	0	0
ARID1A	8289	broad.mit.edu	37	1	27057936	27057937	+	Frame_Shift_Ins	INS	-	C	C			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr1:27057936_27057937insC	uc001bmv.1	+	3	2017_2018	c.1644_1645insC	c.(1642-1647)CAGCCCfs	p.Q548fs	ARID1A_uc001bmt.1_Frame_Shift_Ins_p.Q548fs|ARID1A_uc001bmu.1_Frame_Shift_Ins_p.Q548fs|ARID1A_uc001bmw.1_Frame_Shift_Ins_p.Q165fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	548_549					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Y551fs*72(1)|p.Q548*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCCAGAGCCAGCCCCCCTACTC	0.649			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								23	431	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	G	G	rs113730440		TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr17:26684394_26684395insG	uc002haz.2	-	2	210	c.78_splice	c.e2+1	p.W26_splice	POLDIP2_uc010wag.1_RNA|TMEM199_uc002hba.2_5'Flank|SARM1_uc010wah.1_5'Flank	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2							mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													5	4	---	---	---	---					
DDX5	1655	broad.mit.edu	37	17	62500099	62500102	+	Splice_Site	DEL	ACAG	-	-			TCGA-DU-5853-01A-11D-1893-08	TCGA-DU-5853-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0750c06c-d62b-42d9-804a-a9b9d76b90ed	fb0e600b-10e0-43fb-b877-0981c762da9b	g.chr17:62500099_62500102delACAG	uc002jek.2	-	4	688	c.441_splice	c.e4+1	p.S147_splice	DDX5_uc010deh.2_Splice_Site_p.S147_splice|DDX5_uc002jej.2_Splice_Site_p.S42_splice|DDX5_uc010wqa.1_Intron|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5						cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			TCCCAAACTTACAGACAATGTTTT	0.397			T	ETV4	prostate								7	202	---	---	---	---					
