Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PDIK1L	149420	broad.mit.edu	37	1	26448766	26448766	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr1:26448766G>A	uc010oew.1	+	3	997	c.724G>A	c.(724-726)GCT>ACT	p.A242T	PDIK1L_uc001blj.3_Missense_Mutation_p.A242T|PDIK1L_uc009vsb.2_Missense_Mutation_p.A242T	NM_152835	NP_690048	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	242	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity				0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		TGACATCTTTGCTCTGGGGAT	0.423000													30	63					0	0	0.006320	0	0
C1orf175	374977	broad.mit.edu	37	1	55144970	55144970	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr1:55144970A>G	uc010ooe.1	+	12	2408	c.2084A>G	c.(2083-2085)AAG>AGG	p.K695R	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.K263R|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.K213R|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.K695R|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	695						integral to membrane	binding				0						CAGCAGATAAAGGACCTGCTG	0.577000													4	138					0	0	0.009096	0	0
PTBP2	58155	broad.mit.edu	37	1	97278639	97278639	+	Silent	SNP	T	A	A			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr1:97278639T>A	uc001drq.2	+	13	1689	c.1443T>A	c.(1441-1443)ACT>ACA	p.T481T	PTBP2_uc001drn.2_Silent_p.T486T|PTBP2_uc001dro.2_Silent_p.T481T|PTBP2_uc010otz.1_Silent_p.T497T|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Silent_p.T429T|PTBP2_uc001drr.2_Silent_p.T486T|PTBP2_uc010oua.1_Silent_p.T489T|PTBP2_uc001dru.2_RNA|PTBP2_uc001drs.1_Silent_p.T100T|PTBP2_uc001drt.2_Silent_p.T100T	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	481	RRM 4.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		CTGGGGGCACTGTGAAAGCAT	0.328000													3	101					0	0	0.009096	0	0
MYOF	26509	broad.mit.edu	37	10	95148810	95148810	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr10:95148810A>G	uc001kin.2	-	18	1681	c.1558T>C	c.(1558-1560)TAT>CAT	p.Y520H	MYOF_uc001kio.2_Missense_Mutation_p.Y507H	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	520	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						AGCTCATCATAGGGGTCTGGG	0.408000													3	134					0	0	0.009096	0	0
FAT3	120114	broad.mit.edu	37	11	92085432	92085432	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr11:92085432G>A	uc001pdj.3	+	1	171	c.154G>A	c.(154-156)GTG>ATG	p.V52M		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	52	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TAATGCTACCGTGTATGAGAA	0.488000										TCGA Ovarian(4;0.039)			5	35					0	0	0.000602	0	0
COL2A1	1280	broad.mit.edu	37	12	48370602	48370602	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr12:48370602C>T	uc001rqu.2	-	48	3609	c.3428G>A	c.(3427-3429)GGC>GAC	p.G1143D	COL2A1_uc001rqt.2_5'Flank|COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.G1074D	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	1143	Triple-helical region.		G -> S (in ACG2).		axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CACAGGAGGGCCGGGCAGACC	0.647000													5	9					0	0	0.000602	0	0
POLR3B	55703	broad.mit.edu	37	12	106820987	106820987	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr12:106820987C>T	uc001tlp.2	+	13	1336	c.1114C>T	c.(1114-1116)CTT>TTT	p.L372F	POLR3B_uc001tlq.2_Missense_Mutation_p.L314F	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	372					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTTATCTCTTCTTTTTGAAGA	0.274000													4	16					0	0	0.009096	0	0
SYNE2	23224	broad.mit.edu	37	14	64457244	64457244	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr14:64457244C>G	uc001xgm.2	+	20	2659	c.2429C>G	c.(2428-2430)ACT>AGT	p.T810S	SYNE2_uc001xgl.2_Missense_Mutation_p.T810S	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	810	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GTTCTCACAACTGGGCTTCAG	0.378000													28	111					0	0	0.005443	0	0
FMN1	342184	broad.mit.edu	37	15	33359620	33359620	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr15:33359620C>T	uc001zhf.3	-	1	466	c.466G>A	c.(466-468)GAG>AAG	p.E156K	FMN1_uc001zhg.2_Missense_Mutation_p.E156K	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:Variant_position_missing_in_Q68DA7_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TCCTCTGGCTCCTGGCCACCA	0.517000													4	69					0	0	0.009096	0	0
CHRNA3	1136	broad.mit.edu	37	15	78893607	78893607	+	Silent	SNP	A	G	G			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr15:78893607A>G	uc002bec.2	-	5	1563	c.1377T>C	c.(1375-1377)AAT>AAC	p.N459N	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Silent_p.N459N	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	459	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						CTTTGGCTTCATTTTGTGCTT	0.358000													30	97					0	0	0.008361	0	0
NLGN2	57555	broad.mit.edu	37	17	7318155	7318155	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr17:7318155C>T	uc002ggt.1	+	4	905	c.832C>T	c.(832-834)CAC>TAC	p.H278Y		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	278	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				GATCCTCTCCCACCATTCAGA	0.612000													13	43					0	0	0.013537	0	0
TP53	7157	broad.mit.edu	37	17	7578502	7578502	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr17:7578502A>C	uc002gim.2	-	5	622	c.428T>G	c.(427-429)GTG>GGG	p.V143G	TP53_uc002gig.1_Missense_Mutation_p.V143G|TP53_uc002gih.2_Missense_Mutation_p.V143G|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V11G|TP53_uc010cng.1_Missense_Mutation_p.V11G|TP53_uc002gii.1_Missense_Mutation_p.V11G|TP53_uc010cnh.1_Missense_Mutation_p.V143G|TP53_uc010cni.1_Missense_Mutation_p.V143G|TP53_uc002gij.2_Missense_Mutation_p.V143G|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V50G|TP53_uc002gio.2_Missense_Mutation_p.V11G|TP53_uc010vug.1_Missense_Mutation_p.V104G	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	143	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius).|V -> E (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V143M(16)|p.V143A(15)|p.0?(7)|p.V143E(4)|p.V143L(4)|p.V143V(2)|p.V143fs*27(2)|p.L137_W146del10(1)|p.V143fs*29(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.V11A(1)|p.V50A(1)|p.A138_V143delAKTCPV(1)|p.V143G(1)|p.V143_S149del(1)|p.C141fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCACAGCTGCACAGGGCAGGT	0.587000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	31					0	0	0.003330	0	0
TP53	7157	broad.mit.edu	37	17	7579362	7579363	+	Missense_Mutation	DNP	AA	CC	CC			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr17:7579362_7579363AA>CC	uc002gim.2	-	4	518_519	c.324_325TT>GG	c.(322-327)GGTTTC>GGGGTC	p.F109V	TP53_uc002gig.1_Missense_Mutation_p.F109V|TP53_uc002gih.2_Missense_Mutation_p.F109V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.F109V|TP53_uc010cni.1_Missense_Mutation_p.F109V|TP53_uc002gij.2_Missense_Mutation_p.F109V|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.F70V|TP53_uc010cnk.1_Missense_Mutation_p.F124V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	109	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		F -> S (in sporadic cancers; somatic mutation).|F -> C (in sporadic cancers; somatic mutation).|F -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G59fs*23(3)|p.G108_F109delGF(2)|p.G108del(2)|p.F109_R110delFR(2)|p.V73fs*9(1)|p.G108G(1)|p.F109F(1)|p.F109_R110insXX(1)|p.G105_T125del21(1)|p.?_?ins?(1)|p.Y107fs*44(1)|p.F109C(1)|p.F109S(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y107fs*38(1)|p.F109V(1)|p.Y103_L111>L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCCAGACGGAAACCGTAGCTGC	0.614000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	38					0	0	0.004672	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879577	3879577	+	Silent	SNP	G	A	A			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr18:3879577G>A	uc002kmf.2	-	1	559	c.492C>T	c.(490-492)AAC>AAT	p.N164N	DLGAP1_uc010wyz.1_Silent_p.N164N|DLGAP1_uc002kmk.2_Silent_p.N164N|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	164					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CCTTGCCCCCGTTGACGCTGC	0.711000													33	84					0	0	0.013726	0	0
PDE4C	5143	broad.mit.edu	37	19	18329192	18329192	+	Silent	SNP	G	A	A	rs149723522		TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr19:18329192G>A	uc010xqc.1	-	10	1662	c.1182C>T	c.(1180-1182)GCC>GCT	p.A394A	PDE4C_uc002nik.3_Silent_p.A394A|PDE4C_uc002nil.3_Silent_p.A394A|PDE4C_uc002nif.3_Silent_p.A163A|PDE4C_uc002nig.3_Intron|PDE4C_uc002nih.3_Silent_p.A164A|PDE4C_uc010ebk.2_Silent_p.A288A|PDE4C_uc002nii.3_Silent_p.A362A|PDE4C_uc010ebl.2_Silent_p.A108A|PDE4C_uc010xqd.1_Silent_p.A163A	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	394					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	GGGCCACGTCGGCGGCATGTA	0.637000													42	75					0	0	0.014410	0	0
COQ10B	80219	broad.mit.edu	37	2	198338608	198338608	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr2:198338608T>C	uc002uuh.1	+	5	731	c.677T>C	c.(676-678)ATA>ACA	p.I226T	COQ10B_uc010fsl.1_Missense_Mutation_p.I198T	NM_025147	NP_079423	Q9H8M1	CQ10B_HUMAN	coenzyme Q10 homolog B precursor	226						mitochondrial inner membrane					0			Epithelial(96;0.231)|OV - Ovarian serous cystadenocarcinoma(117;0.246)			GAAACAAATATACCTCGGGAG	0.413000													31	42					0	0	0.004878	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								28	48					0	0	0.010818	0	0
SEMG1	6406	broad.mit.edu	37	20	43836817	43836817	+	Silent	SNP	A	G	G	rs17850164		TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr20:43836817A>G	uc002xni.2	+	2	936	c.879A>G	c.(877-879)ACA>ACG	p.T293T	SEMG1_uc002xnj.2_Intron|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Silent_p.T293T	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	293	58 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				CTTCAAGTACAGAAGAAAGAC	0.383000													3	86					0	0	0.004672	0	0
CDH4	1002	broad.mit.edu	37	20	60419868	60419868	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr20:60419868G>A	uc002ybn.1	+	5	735	c.721G>A	c.(721-723)GCC>ACC	p.A241T	CDH4_uc002ybp.1_Missense_Mutation_p.A167T	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	241	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGAGGAGCACGCCTCTTACCA	0.672000													10	19					0	0	0.010729	0	0
N6AMT1	29104	broad.mit.edu	37	21	30254531	30254531	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr21:30254531T>C	uc002ymo.1	-	3	289	c.263A>G	c.(262-264)GAG>GGG	p.E88G	N6AMT1_uc002ymp.1_Missense_Mutation_p.E88G|N6AMT1_uc002ymq.1_RNA	NM_013240	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1	88					positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity				0						GCGTGCTGTCTCTAGGGTACA	0.358000													19	51					0	0	0.012319	0	0
C22orf29	79680	broad.mit.edu	37	22	19839287	19839287	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr22:19839287G>C	uc002zqg.2	-	2	1097	c.498C>G	c.(496-498)GAC>GAG	p.D166E	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Missense_Mutation_p.D166E|C22orf29_uc002zqi.2_Missense_Mutation_p.D166E|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	166											0	Colorectal(54;0.0993)					GCTCGTAATCGTCAGGCAGGG	0.597000													4	98					0	0	0.001168	0	0
LOC96610	96610	broad.mit.edu	37	22	22782218	22782218	+	RNA	SNP	C	T	T			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr22:22782218C>T	uc011aim.1	+	63		c.6510C>T								Parts of antibodies, mostly variable regions.												0						TGTACTACTACTCAGACTCAG	0.532000													24	45					0	0	0.002780	0	0
TBC1D9	23158	broad.mit.edu	37	4	141543729	141543729	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr4:141543729G>A	uc010ioj.2	-	21	3693	c.3421C>T	c.(3421-3423)CGG>TGG	p.R1141W		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	1141						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CCGTTGTCCCGGGGCGAGGAG	0.637000													20	79					0	0	0.012319	0	0
DNAH8	1769	broad.mit.edu	37	6	38893890	38893891	+	Missense_Mutation	DNP	TA	AT	AT			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr6:38893890_38893891TA>AT	uc003ooe.1	+	72	10971_10972	c.10371_10372TA>AT	c.(10369-10374)ATTATT>ATATTT	p.I3458F	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGAATGGCATTATTGTGACAAA	0.411000													15	116					0	0	0.004672	0	0
SHPRH	257218	broad.mit.edu	37	6	146215310	146215310	+	Silent	SNP	T	C	C			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr6:146215310T>C	uc003qlf.2	-	27	5070	c.4671A>G	c.(4669-4671)CAA>CAG	p.Q1557Q	SHPRH_uc003qld.2_Silent_p.Q1561Q|SHPRH_uc003qle.2_Silent_p.Q1561Q	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1557	Helicase C-terminal.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CACGACTGATTTGTGCAAATT	0.313000													4	32					0	0	0.000602	0	0
TBP	6908	broad.mit.edu	37	6	170871082	170871082	+	Silent	SNP	G	A	A			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr6:170871082G>A	uc003qxt.2	+	3	490	c.258G>A	c.(256-258)CAG>CAA	p.Q86Q	TBP_uc003qxu.2_Silent_p.Q86Q|TBP_uc011ehf.1_Silent_p.Q66Q|TBP_uc011ehg.1_Silent_p.Q86Q	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	86	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.199000													4	13					0	0	0.009096	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86542420	86542420	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr7:86542420G>C	uc011kha.1	-	14	2017	c.1832C>G	c.(1831-1833)TCT>TGT	p.S611C	KIAA1324L_uc003uif.1_Missense_Mutation_p.S371C|KIAA1324L_uc011kgz.1_Missense_Mutation_p.S497C|KIAA1324L_uc003uie.2_Missense_Mutation_p.S444C	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	611	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					CGACTGTTCAGAACCGAGGGC	0.517000													11	53					0	0	0.010729	0	0
DLC1	10395	broad.mit.edu	37	8	12952306	12952306	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr8:12952306G>A	uc003wwm.2	-	12	3932	c.3488C>T	c.(3487-3489)ACG>ATG	p.T1163M	DLC1_uc003wwk.1_Missense_Mutation_p.T726M|DLC1_uc003wwl.1_Missense_Mutation_p.T760M|DLC1_uc011kxx.1_Missense_Mutation_p.T652M	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1163	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GAGTTTGTTCGTCATTAGTGG	0.448000													31	34					0	0	0.003755	0	0
TEX15	56154	broad.mit.edu	37	8	30702110	30702110	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr8:30702110T>C	uc003xil.2	-	1	4424	c.4424A>G	c.(4423-4425)TAC>TGC	p.Y1475C		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1475										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GCTTCTTTTGTAAACAGAATC	0.338000													39	42					0	0	0.005524	0	0
UBR5	51366	broad.mit.edu	37	8	103359284	103359284	+	Silent	SNP	T	C	C			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr8:103359284T>C	uc003ykr.1	-	6	456	c.423A>G	c.(421-423)GGA>GGG	p.G141G	UBR5_uc003yks.1_Silent_p.G141G	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	141					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CAGAGGATCCTCCACCACTTC	0.483000													72	87					0	0	0.014410	0	0
PPP3R2	5535	broad.mit.edu	37	9	104357209	104357209	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr9:104357209A>C	uc004bbr.2	-	1	75	c.4T>G	c.(4-6)TCC>GCC	p.S2A	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_RNA	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	Error:Variant_position_missing_in_Q96LZ3_after_alignment							calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	CCCATTGTGGACATCTGGCAA	0.607000													22	45					0	0	0.002780	0	0
SCAI	286205	broad.mit.edu	37	9	127734030	127734030	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr9:127734030C>T	uc004bpe.2	-	16	1574	c.1493G>A	c.(1492-1494)GGC>GAC	p.G498D	SCAI_uc004bpd.2_Missense_Mutation_p.G521D|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	498					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						TTCCCATAGGCCTCTGCGCAT	0.428000													54	92					0	0	0.014410	0	0
ZNF23	7571	broad.mit.edu	37	16	71483441	71483444	+	Frame_Shift_Del	DEL	AATT	-	-			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chr16:71483441_71483444delAATT	uc002faf.2	-	6	1298_1301	c.484_487delAATT	c.(484-489)AATTCTfs	p.N162fs	ZNF23_uc002fad.2_Frame_Shift_Del_p.N104fs|ZNF23_uc002fae.2_Frame_Shift_Del_p.N104fs|ZNF23_uc010vmf.1_Frame_Shift_Del_p.N104fs|ZNF23_uc002fag.2_Frame_Shift_Del_p.N104fs|ZNF23_uc002fah.2_Frame_Shift_Del_p.N162fs|ZNF23_uc002fai.2_Frame_Shift_Del_p.N201fs	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	162_163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		CTTTCCTCAGAATTAATTATTTCA	0.402													10	109	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76938777	76938777	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DU-6395-01A-12D-1705-08	TCGA-DU-6395-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	3189bd5c-ac35-4564-bbd1-744e17faf46d	71783be8-05e1-4cf5-9bf1-4f58ce54a273	g.chrX:76938777delT	uc004ecp.3	-	9	2203	c.1971delA	c.(1969-1971)CCAfs	p.P657fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.P619fs|ATRX_uc004eco.3_Frame_Shift_Del_p.P442fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.P589fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.P628fs|ATRX_uc010nly.1_Frame_Shift_Del_p.P602fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	657					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCTTTACACGTGGGGATCTTC	0.378			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						147	43	---	---	---	---					
