Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CROCCL1	84809	broad.mit.edu	37	1	16945358	16945358	+	RNA	SNP	G	C	C	rs945905	by1000genomes	TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr1:16945358G>C	uc010ocf.1	-	4		c.799C>G			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						AGTAGGAGAAGAGAGAGGAAG	0.567000													4	15					0	0	0.150653	0	0
UBXN10	127733	broad.mit.edu	37	1	20517773	20517773	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr1:20517773G>A	uc001bdb.2	+	2	803	c.719G>A	c.(718-720)AGC>AAC	p.S240N		NM_152376	NP_689589	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	240	UBX.									ovary(1)	1						CGACACTGCAGCATTGAAACA	0.502000													3	83					0	0	0.115264	0	0
EIF4G3	8672	broad.mit.edu	37	1	21181494	21181494	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr1:21181494C>T	uc001bec.2	-	21	3498	c.3242G>A	c.(3241-3243)GGT>GAT	p.G1081D	EIF4G3_uc010odi.1_Missense_Mutation_p.G685D|EIF4G3_uc010odj.1_Missense_Mutation_p.G1080D|EIF4G3_uc009vpz.2_Missense_Mutation_p.G801D|EIF4G3_uc001bed.2_Missense_Mutation_p.G1081D|EIF4G3_uc001bef.2_Missense_Mutation_p.G1117D|EIF4G3_uc001bee.2_Missense_Mutation_p.G1087D	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1081					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CTTTGCTCCACCACTGCTGCC	0.473000													43	55					0	0	0.870114	0	0
RYR2	6262	broad.mit.edu	37	1	237872331	237872331	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr1:237872331T>C	uc001hyl.1	+	69	10195	c.10075T>C	c.(10075-10077)TTC>CTC	p.F3359L	RYR2_uc010pxz.1_Missense_Mutation_p.F314L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3359					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCTAGATGAGTTCACCACACT	0.463000													8	10					0	0	0.307466	0	0
BMPR1A	657	broad.mit.edu	37	10	88679128	88679128	+	Silent	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr10:88679128C>T	uc001kdy.2	+	10	1616	c.1068C>T	c.(1066-1068)CCC>CCT	p.P356P		NM_004329	NP_004320	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	356	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			lung(3)|large_intestine(1)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	8						AAGGAAAGCCCGCAATTGCTC	0.483000			Mis|N|F			gastrointestinal polyps			Hereditary_Mixed_Polyposis_syndrome_type_2|Juvenile_Polyposis				3	47					0	0	0.115264	0	0
MKI67	4288	broad.mit.edu	37	10	129906452	129906452	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr10:129906452C>T	uc001lke.2	-	13	3847	c.3652G>A	c.(3652-3654)GCC>ACC	p.A1218T	MKI67_uc001lkf.2_Missense_Mutation_p.A858T|MKI67_uc009yav.1_Missense_Mutation_p.A793T|MKI67_uc009yaw.1_Missense_Mutation_p.A368T	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1218	16 X 122 AA approximate repeats.|2.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				AGAGCCTGGGCCTTTTCCTTA	0.483000													19	80					0	0	0.539581	0	0
OR52M1	119772	broad.mit.edu	37	11	4567291	4567291	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr11:4567291A>T	uc010qyf.1	+	1	871	c.871A>T	c.(871-873)AAT>TAT	p.N291Y		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCAATCCTCAATCCCATTGT	0.453000													27	23					0	0	0.717897	0	0
ARAP1	116985	broad.mit.edu	37	11	72396719	72396719	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr11:72396719C>G	uc001osu.2	-	35	4532	c.4343G>C	c.(4342-4344)CGC>CCC	p.R1448P	ARAP1_uc001osv.2_Missense_Mutation_p.R1437P|ARAP1_uc001osr.2_Missense_Mutation_p.R1208P|ARAP1_uc001oss.2_Missense_Mutation_p.R1203P|ARAP1_uc009yth.2_Missense_Mutation_p.R1131P|ARAP1_uc010rre.1_Missense_Mutation_p.R1192P	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1448					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						TCAGACGTTGCGCAGAAGCTG	0.607000													11	24					0	0	0.387290	0	0
FGD6	55785	broad.mit.edu	37	12	95531311	95531311	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr12:95531311A>G	uc001tdp.3	-	7	3205	c.2981T>C	c.(2980-2982)GTT>GCT	p.V994A	FGD6_uc009zsx.2_Missense_Mutation_p.V127A|FGD6_uc001tdq.1_Missense_Mutation_p.V30A	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	994	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						AAATTCTCTAACAACAGCAGC	0.264000													45	67					0	0	0.870114	0	0
CHST11	50515	broad.mit.edu	37	12	105151362	105151362	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr12:105151362G>C	uc001tkx.1	+	4	1131	c.840G>C	c.(838-840)GAG>GAC	p.E280D	CHST11_uc001tky.2_Missense_Mutation_p.E275D|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	280	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						GCAAGTACGAGACACTGGAAG	0.532000													7	10					0	0	0.335167	0	0
TBX5	6910	broad.mit.edu	37	12	114793418	114793418	+	Silent	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr12:114793418G>A	uc001tvo.2	-	9	1971	c.1476C>T	c.(1474-1476)GGC>GGT	p.G492G	TBX5_uc001tvp.2_Silent_p.G492G|TBX5_uc001tvq.2_Silent_p.G442G	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	492					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TCCTTGGCACGCCATGAGAGT	0.602000													17	18					0	0	0.575678	0	0
WDR66	144406	broad.mit.edu	37	12	122399967	122399967	+	Silent	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr12:122399967C>T	uc009zxk.2	+	15	2533	c.2391C>T	c.(2389-2391)ACC>ACT	p.T797T		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	797							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GCTATCCCACCTGCATGGTCT	0.498000													18	93					0	0	0.539581	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751659	19751659	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr13:19751659T>C	uc009zzj.2	-	4	513	c.464A>G	c.(463-465)GAG>GGG	p.E155G		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	155					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TGAGAGCCGCTCCATGAGCAG	0.587000													35	53					0	0	0.788014	0	0
ADAM6	8755	broad.mit.edu	37	14	106691922	106691922	+	RNA	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr14:106691922C>T	uc010tyt.1	-	754		c.20441G>A								Parts of antibodies, mostly variable regions.												0						TCAGGGACCCCCCAGGCTTGA	0.587000													3	62					0	0	0.150653	0	0
MYO5C	55930	broad.mit.edu	37	15	52553129	52553129	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr15:52553129C>T	uc010bff.2	-	10	1380	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K	MYO5C_uc010uga.1_RNA|MYO5C_uc010ugb.1_RNA|MYO5C_uc010ugc.1_3'UTR	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	415	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		TTAATTCTCTCCACAATGAAG	0.473000													44	62					0	0	0.847076	0	0
ANXA2	302	broad.mit.edu	37	15	60653219	60653219	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr15:60653219C>T	uc002agn.2	-	6	438	c.278G>A	c.(277-279)GGC>GAC	p.G93D	ANXA2_uc002agk.2_Missense_Mutation_p.G93D|ANXA2_uc002agl.2_Missense_Mutation_p.G93D|ANXA2_uc002agm.2_Missense_Mutation_p.G111D|ANXA2_uc010uhd.1_RNA|ANXA2_uc010bgj.2_Missense_Mutation_p.G93D	NM_001136015	NP_001129487	P07355	ANXA2_HUMAN	annexin A2 isoform 2	93	Annexin 1.				angiogenesis|positive regulation of vesicle fusion|skeletal system development	basement membrane|melanosome|midbody|soluble fraction	calcium ion binding|calcium-dependent phospholipid binding|cytoskeletal protein binding|phospholipase inhibitor activity			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Tenecteplase(DB00031)	CTCCAGGTGGCCAGATAAGGC	0.398000													3	39					0	0	0.115264	0	0
IL16	3603	broad.mit.edu	37	15	81598375	81598375	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr15:81598375C>T	uc002bgh.3	+	17	3923	c.3547C>T	c.(3547-3549)CGC>TGC	p.R1183C	IL16_uc010blq.1_Missense_Mutation_p.R1137C|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.R1225C|IL16_uc002bgg.2_Missense_Mutation_p.R1183C|IL16_uc002bgi.1_Missense_Mutation_p.R573C|IL16_uc002bgj.2_Missense_Mutation_p.R677C|IL16_uc002bgk.2_Missense_Mutation_p.R482C|IL16_uc002bgl.1_Missense_Mutation_p.R482C|IL16_uc010unq.1_Missense_Mutation_p.R482C	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	1183	PDZ 3.|Interaction with PPP1R12A, PPP1R12B and PPP1R12C.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GGCCATCCTCCGCCAAGCTCG	0.582000													18	108					0	0	0.539581	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	10					0	0	0.639603	0	0
CCDC144C	348254	broad.mit.edu	37	17	20224797	20224797	+	RNA	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr17:20224797C>T	uc010cqy.1	+	1		c.311C>T				NR_023380				Homo sapiens cDNA FLJ59693 complete cds, moderately similar to Ankyrin repeat domain-containing protein 26.												0						GGTGGAAAAACAGCGTCGGCA	0.637000													4	104					0	0	0.217242	0	0
SEZ6	124925	broad.mit.edu	37	17	27286489	27286489	+	Silent	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr17:27286489G>A	uc002hdp.2	-	9	1967	c.1773C>T	c.(1771-1773)GCC>GCT	p.A591A	SEZ6_uc010crx.1_5'Flank|SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Silent_p.A591A|SEZ6_uc002hdq.1_Silent_p.A466A	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	591	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			CGCTGCACACGGCTGGAAGGC	0.602000													15	39					0	0	0.479597	0	0
DCAKD	79877	broad.mit.edu	37	17	43101983	43101983	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr17:43101983C>T	uc002ihx.2	-	4	770	c.514G>A	c.(514-516)GCC>ACC	p.A172T	DCAKD_uc010daa.1_Missense_Mutation_p.A172T|DCAKD_uc010dab.1_Missense_Mutation_p.A172T	NM_024819	NP_079095	Q8WVC6	DCAKD_HUMAN	dephospho-CoA kinase domain containing	172	DPCK.				coenzyme A biosynthetic process		ATP binding|dephospho-CoA kinase activity				0		Prostate(33;0.155)				ACATGGCGGGCCATGCGGGCC	0.642000													17	32					0	0	0.539581	0	0
KIF2B	84643	broad.mit.edu	37	17	51900796	51900796	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr17:51900796G>T	uc002iua.2	+	1	558	c.402G>T	c.(400-402)AGG>AGT	p.R134S	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	134					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TGGATGTGAGGGTCCCCAGCA	0.587000													27	38					9.39395e-14	9.69698e-14	0.706142	1	0
SLC38A10	124565	broad.mit.edu	37	17	79249788	79249788	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr17:79249788G>A	uc002jzz.1	-	8	1268	c.893C>T	c.(892-894)ACG>ATG	p.T298M	SLC38A10_uc002jzy.1_Missense_Mutation_p.T216M|SLC38A10_uc002kab.2_Missense_Mutation_p.T298M	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	298					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ACACAGCAGCGTGCTCAGGGC	0.612000													17	34					0	0	0.520397	0	0
KCNG2	26251	broad.mit.edu	37	18	77659303	77659303	+	Silent	SNP	C	G	G			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr18:77659303C>G	uc010xfl.1	+	2	888	c.888C>G	c.(886-888)CTC>CTG	p.L296L		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	296	Helical; Voltage-sensor; Name=Segment S4; (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		TGCGCGTGCTCTACGTGATGC	0.741000													3	9					0	0	0.115264	0	0
CREB3L3	84699	broad.mit.edu	37	19	4171094	4171094	+	Silent	SNP	C	G	G			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr19:4171094C>G	uc002lzl.2	+	8	1013	c.897C>G	c.(895-897)CTC>CTG	p.L299L	CREB3L3_uc002lzm.2_Silent_p.L289L|CREB3L3_uc010xib.1_Silent_p.L288L|CREB3L3_uc010xic.1_Missense_Mutation_p.L255V	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	299	Cytoplasmic (Potential).|Leucine-zipper.				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		TAAGGTCCCTCTTGGAGCAAC	0.612000													20	32					0	0	0.681144	0	0
LRFN1	57622	broad.mit.edu	37	19	39798915	39798915	+	Silent	SNP	G	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr19:39798915G>C	uc002okw.2	-	2	1674	c.1674C>G	c.(1672-1674)CGC>CGG	p.R558R		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	558	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			ACACCTTATAGCGGATCATGA	0.657000													6	17					0	0	0.248553	0	0
SPTBN4	57731	broad.mit.edu	37	19	41063165	41063165	+	Silent	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr19:41063165C>T	uc002ony.2	+	26	5612	c.5526C>T	c.(5524-5526)GAC>GAT	p.D1842D	SPTBN4_uc002onx.2_Silent_p.D1842D|SPTBN4_uc002onz.2_Silent_p.D1842D|SPTBN4_uc010egx.2_Silent_p.D585D|SPTBN4_uc002ooa.2_Silent_p.D518D	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1842	Spectrin 16.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCTTCAGTGACGCCCGAGAGC	0.657000													19	26					0	0	0.557998	0	0
ZNF638	27332	broad.mit.edu	37	2	71658529	71658529	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr2:71658529G>A	uc002shx.2	+	26	6042	c.5723G>A	c.(5722-5724)GGC>GAC	p.G1908D	ZNF638_uc002shy.2_Missense_Mutation_p.G1908D|ZNF638_uc002shz.2_Missense_Mutation_p.G1908D|ZNF638_uc002sia.2_Missense_Mutation_p.G1908D|ZNF638_uc010fed.2_RNA|ZNF638_uc002sic.2_Missense_Mutation_p.G1005D|ZNF638_uc002sid.2_Missense_Mutation_p.G277D	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1908					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TCTTCTTCAGGCAAATCAGTG	0.323000													4	33					0	0	0.150653	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489408	133489408	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr2:133489408G>C	uc002ttp.2	-	17	5719	c.5345C>G	c.(5344-5346)CCT>CGT	p.P1782R	NCKAP5_uc002ttq.2_Missense_Mutation_p.P463R	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1782							protein binding				0						GCTATCTGCAGGGCGCTGGCC	0.587000													31	49					0	0	0.750413	0	0
THSD7B	80731	broad.mit.edu	37	2	138400162	138400162	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr2:138400162T>C	uc002tva.1	+	20	3817	c.3817T>C	c.(3817-3819)TAC>CAC	p.Y1273H	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GACCCCCTGCTACAGCTGGGT	0.488000													28	74					0	0	0.740014	0	0
FASTKD1	79675	broad.mit.edu	37	2	170411653	170411653	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr2:170411653G>A	uc002uev.3	-	7	1583	c.1195C>T	c.(1195-1197)CTT>TTT	p.L399F	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.L385F	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	399					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						AATTCTCTAAGTTTCGCAAAA	0.308000													21	23					0	0	0.592651	0	0
ZNF385B	151126	broad.mit.edu	37	2	180634316	180634316	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr2:180634316T>A	uc002unn.3	-	3	771	c.167A>T	c.(166-168)AAA>ATA	p.K56I		NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	56	Matrin-type 1.					nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GCGGTGGGATTTGCCGTTGGA	0.567000													14	29					0	0	0.457914	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								21	49					0	0	0.624587	0	0
BARD1	580	broad.mit.edu	37	2	215610535	215610535	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr2:215610535C>T	uc002veu.2	-	8	1856	c.1721G>A	c.(1720-1722)GGC>GAC	p.G574D	BARD1_uc010zjm.1_Missense_Mutation_p.G430D	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	574	BRCT 1.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CAGCCCACTGCCTATAAGTAC	0.393000									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				21	151					0	0	0.639603	0	0
GZF1	64412	broad.mit.edu	37	20	23350986	23350986	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr20:23350986C>T	uc010gdb.2	+	7	2218	c.2044C>T	c.(2044-2046)CTC>TTC	p.L682F	GZF1_uc002wsy.2_Missense_Mutation_p.L682F|GZF1_uc010zsq.1_Missense_Mutation_p.L206F|GZF1_uc010zsr.1_Missense_Mutation_p.L191F|GZF1_uc002wsz.2_Missense_Mutation_p.L682F	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	682					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					CCAGGACACCCTCCTGGCCAC	0.552000													5	52					0	0	0.184627	0	0
TBX1	6899	broad.mit.edu	37	22	19751681	19751681	+	Silent	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr22:19751681C>T	uc002zqb.2	+	5	645	c.516C>T	c.(514-516)TAC>TAT	p.Y172Y	TBX1_uc002zqa.1_Silent_p.Y172Y|TBX1_uc002zqc.2_Silent_p.Y172Y	NM_080646	NP_542377	O43435	TBX1_HUMAN	T-box 1 isoform A	172	T-box.				embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)	2	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				GCTCCAGGTACGCCTTCCACA	0.667000													10	17					0	0	0.361761	0	0
APOL4	80832	broad.mit.edu	37	22	36587386	36587386	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr22:36587386G>A	uc003aox.2	-	6	1018	c.793C>T	c.(793-795)CGA>TGA	p.R265*	APOL4_uc003aow.2_Nonsense_Mutation_p.R262*|APOL4_uc010gww.2_Nonsense_Mutation_p.R107*	NM_145660	NP_663693	Q9BPW4	APOL4_HUMAN	apolipoprotein L4 isoform 2 precursor	265					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding				0						GGTACATATCGCCAAGCAATC	0.483000													20	37					0	0	0.575678	0	0
MST1	4485	broad.mit.edu	37	3	49722502	49722502	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr3:49722502C>G	uc003cxg.2	-	14	1637	c.1565G>C	c.(1564-1566)GGG>GCG	p.G522A		NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	508	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TAGAGACCCCCCGCAGAAATG	0.577000													3	6					0	0	0.184627	0	0
UGT2B4	7363	broad.mit.edu	37	4	70352368	70352368	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr4:70352368T>G	uc003hek.3	-	4	1096	c.1049A>C	c.(1048-1050)AAT>ACT	p.N350T	UGT2B4_uc011cap.1_Missense_Mutation_p.N214T|UGT2B4_uc003hel.3_Missense_Mutation_p.N350T	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	350					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CAGCCGAGTATTGAGTCCTAA	0.343000													55	107					0	0	0.870114	0	0
ANKRA2	57763	broad.mit.edu	37	5	72849256	72849256	+	Silent	SNP	T	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr5:72849256T>C	uc003kcu.1	-	8	1507	c.861A>G	c.(859-861)CTA>CTG	p.L287L		NM_023039	NP_075526	Q9H9E1	ANRA2_HUMAN	ankyrin repeat, family A (RFXANK-like), 2	287						cytoskeleton|cytosol|membrane	low-density lipoprotein particle binding				0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)		OV - Ovarian serous cystadenocarcinoma(47;3.71e-54)		GGGCTACAGCTAGATCCATAG	0.328000													18	27					0	0	0.592651	0	0
AGXT2L2	85007	broad.mit.edu	37	5	177649360	177649360	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr5:177649360T>C	uc003miz.2	-	8	1175	c.923A>G	c.(922-924)AAC>AGC	p.N308S	AGXT2L2_uc003miy.2_Missense_Mutation_p.N33S|AGXT2L2_uc003mjc.2_Missense_Mutation_p.N267S|AGXT2L2_uc003mja.2_RNA|AGXT2L2_uc003mjb.2_Missense_Mutation_p.N33S|AGXT2L2_uc003mjd.1_Missense_Mutation_p.N166S	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	308						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ACTCACCGTGTTGAAGTACTC	0.587000													3	35					0	0	0.115264	0	0
SCGN	10590	broad.mit.edu	37	6	25682193	25682193	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr6:25682193C>G	uc003nfb.2	+	7	689	c.486C>G	c.(484-486)GAC>GAG	p.D162E	SCGN_uc010jpz.2_Intron	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	162	4 (Potential).|EF-hand 4.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						AGATTTTTGACAGAAATAAAG	0.353000													16	34					0	0	0.539581	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32975239	32975239	+	Silent	SNP	G	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr6:32975239G>C	uc003ocr.2	-	3	538	c.462C>G	c.(460-462)GTC>GTG	p.V154V	HLA-DOA_uc010juj.2_Silent_p.V124V|HLA-DOA_uc010jui.2_Silent_p.V154V	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	154	Extracellular (Potential).|Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						CTCCCTCAGTGACAGTTTGGC	0.582000													47	86					0	0	0.870114	0	0
TFAP2D	83741	broad.mit.edu	37	6	50683278	50683278	+	Silent	SNP	G	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr6:50683278G>T	uc003paf.2	+	2	1001	c.489G>T	c.(487-489)CTG>CTT	p.L163L	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	163							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					AAAGACTCCTGCCAGGGCCCA	0.632000													33	61					3.09479e-21	3.24699e-21	0.827153	1	0
MUC17	140453	broad.mit.edu	37	7	100679845	100679845	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr7:100679845C>A	uc003uxp.1	+	3	5201	c.5148C>A	c.(5146-5148)GAC>GAA	p.D1716E	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1716	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|26.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTCCCGTTGACAACAGCACAC	0.473000													89	117					3.65056e-27	3.89393e-27	0.870114	1	0
TAS2R16	50833	broad.mit.edu	37	7	122634819	122634819	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr7:122634819C>G	uc003vkl.1	-	1	936	c.870G>C	c.(868-870)AAG>AAC	p.K290N		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	290	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						AGGCCTAGCACTTTCCCTTTA	0.418000													4	189					0	0	0.184627	0	0
FLJ10661	286042	broad.mit.edu	37	8	8093629	8093629	+	RNA	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr8:8093629C>T	uc011kwt.1	+	6		c.684C>T			FLJ10661_uc010lrq.2_Intron|FLJ10661_uc003wsf.3_RNA	NR_024362				Homo sapiens cDNA FLJ60033 complete cds, highly similar to Protein FAM86A.												0						CCCGGGCATACATCTTCAGCG	0.567000													7	9					0	0	0.278610	0	0
EEF1D	1936	broad.mit.edu	37	8	144663399	144663399	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr8:144663399C>T	uc011lki.1	-	4	558	c.289G>A	c.(289-291)GTG>ATG	p.V97M	NAPRT1_uc003yym.3_5'Flank|NAPRT1_uc003yyn.3_5'Flank|NAPRT1_uc011lkh.1_5'Flank|NAPRT1_uc003yyo.3_5'Flank|EEF1D_uc003yyp.1_Missense_Mutation_p.V439M|EEF1D_uc003yyq.1_Missense_Mutation_p.V513M|EEF1D_uc011lkj.1_Missense_Mutation_p.V462M|EEF1D_uc003yyr.2_Missense_Mutation_p.V463M|EEF1D_uc003yyt.2_Missense_Mutation_p.V463M|EEF1D_uc011lkk.1_Missense_Mutation_p.V97M|EEF1D_uc003yys.2_Missense_Mutation_p.V97M|EEF1D_uc003yyv.2_Missense_Mutation_p.V73M|EEF1D_uc003yyu.2_Missense_Mutation_p.V97M|EEF1D_uc011lkl.1_Intron	NM_001130057	NP_001123529	P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta	97					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			ovary(1)|kidney(1)|skin(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GGGGCCTCACCGCCACGCAGA	0.692000													5	23					0	0	0.184627	0	0
GPR64	10149	broad.mit.edu	37	X	19027859	19027859	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chrX:19027859A>T	uc004cyx.2	-	18	1471	c.1307T>A	c.(1306-1308)TTT>TAT	p.F436Y	GPR64_uc004cyy.2_Missense_Mutation_p.F433Y|GPR64_uc004cyz.2_Missense_Mutation_p.F422Y|GPR64_uc004czb.2_Missense_Mutation_p.F436Y|GPR64_uc004czc.2_Missense_Mutation_p.F420Y|GPR64_uc004czd.2_Missense_Mutation_p.F412Y|GPR64_uc004cze.2_Missense_Mutation_p.F406Y|GPR64_uc004czf.2_Missense_Mutation_p.F398Y|GPR64_uc004cza.2_Missense_Mutation_p.F414Y|GPR64_uc004cyw.2_Missense_Mutation_p.F420Y|GPR64_uc010nfj.2_Missense_Mutation_p.F406Y	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	436	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					CGTGTTTGAAAAGTTCAGCTG	0.363000													46	50					0	0	0.870114	0	0
SAT1	6303	broad.mit.edu	37	X	23801978	23801978	+	Silent	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chrX:23801978G>A	uc004dau.2	+	3	374	c.180G>A	c.(178-180)CCG>CCA	p.P60P	SAT1_uc010nfv.2_Silent_p.P60P|SAT1_uc004dav.2_RNA	NM_002970	NP_002961	P21673	SAT1_HUMAN	diamine N-acetyltransferase 1	60	N-acetyltransferase.				angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)	CAGAAGTGCCGAAAGAGCACT	0.542000													19	29					0	0	0.608945	0	0
POLA1	5422	broad.mit.edu	37	X	24735546	24735546	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chrX:24735546G>C	uc004dbl.2	+	9	851	c.828G>C	c.(826-828)GAG>GAC	p.E276D	POLA1_uc004dbm.2_Missense_Mutation_p.E282D|POLA1_uc004dbn.2_Missense_Mutation_p.E140D	NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	276					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	GGGACAAAGAGAGTGAGCCAG	0.498000													16	24					0	0	0.479597	0	0
TRO	7216	broad.mit.edu	37	X	54955789	54955789	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chrX:54955789G>A	uc004dtq.2	+	12	2739	c.2632G>A	c.(2632-2634)GTC>ATC	p.V878I	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.V409I|TRO_uc004dtw.2_Missense_Mutation_p.V481I|TRO_uc004dtx.2_Missense_Mutation_p.V261I	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	878	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						AACGAGCACAGTCTTCAGTAG	0.567000													24	36					0	0	0.639603	0	0
ATRX	546	broad.mit.edu	37	X	76909629	76909629	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chrX:76909629G>A	uc004ecp.3	-	14	4508	c.4276C>T	c.(4276-4278)CGA>TGA	p.R1426*	ATRX_uc004ecq.3_Nonsense_Mutation_p.R1388*|ATRX_uc004eco.3_Nonsense_Mutation_p.R1211*|ATRX_uc004ecr.2_Nonsense_Mutation_p.R1358*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1426					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTAATACGTCGCCTTTTCTTT	0.328000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						43	85					0	0	0.870114	0	0
LIM2	3982	broad.mit.edu	37	19	51885677	51885678	+	Frame_Shift_Ins	INS	-	A	A			TCGA-DU-6396-01A-11D-1705-08	TCGA-DU-6396-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	cb4a697c-3444-49ed-9085-cec75607f61d	2c1dd78a-2e86-4815-b003-63d5cfc62e38	g.chr19:51885677_51885678insA	uc002pwm.2	-	3	363_364	c.319_320insT	c.(319-321)TCCfs	p.S107fs	LIM2_uc002pwl.2_Frame_Shift_Ins_p.S149fs	NM_001161748	NP_001155220	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa isoform	107	Helical; (Potential).				cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens				0		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		CTCACTTGAGGAAAAAAACATG	0.312													30	30	---	---	---	---					
