Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARHGEF10L	55160	broad.mit.edu	37	1	17950915	17950915	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:17950915G>A	uc001ban.2	+	13	1393	c.1234G>A	c.(1234-1236)GAC>AAC	p.D412N	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.D373N|ARHGEF10L_uc001bao.2_Missense_Mutation_p.D373N|ARHGEF10L_uc001bap.2_Missense_Mutation_p.D373N|ARHGEF10L_uc010ocr.1_Missense_Mutation_p.D170N|ARHGEF10L_uc001baq.2_Missense_Mutation_p.D178N|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.D190N|ARHGEF10L_uc001bar.2_Intron|ARHGEF10L_uc009vpf.2_5'Flank	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	412	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		TGTGTACAGTGACTACGTGAA	0.557000													4	105					0	0	0.009096	0	0
ZMPSTE24	10269	broad.mit.edu	37	1	40758165	40758165	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:40758165G>A	uc001cfg.2	+	10	1463	c.1252G>A	c.(1252-1254)GCT>ACT	p.A418T		NM_005857	NP_005848	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	418						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity				0	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			TGAGTTTCAAGCTGATGCATT	0.388000													23	108					0	0	0.014323	0	0
MAST2	23139	broad.mit.edu	37	1	46474027	46474027	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:46474027A>G	uc001cov.2	+	9	1245	c.962A>G	c.(961-963)AAA>AGA	p.K321R	MAST2_uc001cow.2_Missense_Mutation_p.K321R|MAST2_uc001coy.1_Missense_Mutation_p.K29R|MAST2_uc001coz.1_Missense_Mutation_p.K206R|MAST2_uc009vya.2_Missense_Mutation_p.K243R|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	321					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CATGTTTACAAAGAAAGATTC	0.433000													8	31					0	0	0.003080	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507115	74507115	+	Silent	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:74507115T>C	uc001dfy.3	-	7	1692	c.1500A>G	c.(1498-1500)AGA>AGG	p.R500R	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	500										ovary(2)	2						ACAGAGCTTTTCTCTCTCTAG	0.338000													6	136					0	0	0.001168	0	0
NTNG1	22854	broad.mit.edu	37	1	107973470	107973470	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:107973470T>C	uc001dvh.3	+	6	1904	c.1186T>C	c.(1186-1188)TGT>CGT	p.C396R	NTNG1_uc001dvf.3_Intron|NTNG1_uc010out.1_Intron|NTNG1_uc001dvc.3_Intron|NTNG1_uc001dvi.2_Intron|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_Intron|NTNG1_uc001dvg.2_Intron|NTNG1_uc009wem.2_Intron	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	396	Laminin EGF-like 2.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		AGGGCAGCACTGTGAGTTATG	0.443000													3	33					0	0	0.004672	0	0
NBPF10	100132406	broad.mit.edu	37	1	145359169	145359169	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:145359169T>A	uc001end.3	+	74	9369	c.9334T>A	c.(9334-9336)TTG>ATG	p.L3112M	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oyq.1_Intron|NBPF10_uc010oyr.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3037											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCGTGTTGGCTTGGCTGTTGA	0.458000													6	265					0	0	0.001168	0	0
LMX1A	4009	broad.mit.edu	37	1	165183011	165183011	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:165183011T>C	uc001gcy.1	-	4	757	c.536A>G	c.(535-537)CAT>CGT	p.H179R	LMX1A_uc001gcz.1_Missense_Mutation_p.H179R|LMX1A_uc001gcw.1_5'Flank|LMX1A_uc001gcx.1_5'Flank	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	179						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CCCTGCCCCATGGGCTGACTT	0.498000													91	97					0	0	0.014410	0	0
RXRG	6258	broad.mit.edu	37	1	165386373	165386373	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:165386373C>T	uc001gda.2	-	4	827	c.527G>A	c.(526-528)CGG>CAG	p.R176Q		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	176	NR C4-type.|Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	TTTATTATCCCGACACGTGTA	0.498000													4	103					0	0	0.009096	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179815253	179815253	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:179815253G>A	uc001gnk.2	-	6	1754	c.1366C>T	c.(1366-1368)CCA>TCA	p.P456S	TOR1AIP2_uc001gnl.2_Missense_Mutation_p.P456S	NM_145034	NP_659471	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	456						endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1						GGCTGGACTGGCAGTACCAGG	0.463000													3	71					0	0	0.004672	0	0
HMCN1	83872	broad.mit.edu	37	1	185951454	185951454	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr1:185951454C>T	uc001grq.1	+	18	2952	c.2723C>T	c.(2722-2724)ACT>ATT	p.T908I	HMCN1_uc001grr.1_Missense_Mutation_p.T249I	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	908	Ig-like C2-type 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAGCAGCTTACTTTGCCCTGT	0.418000													36	108					0	0	0.003271	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508692	37508692	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr10:37508692C>A	uc001iza.1	+	34	3983	c.3884C>A	c.(3883-3885)ACA>AAA	p.T1295K		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1351						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AGCAAGATAACAATTGATATT	0.294000													9	24					2.17888e-05	2.41233e-05	0.006214	1	0
OR13A1	79290	broad.mit.edu	37	10	45799644	45799644	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr10:45799644G>C	uc001jcc.1	-	4	536	c.227C>G	c.(226-228)CCT>CGT	p.P76R	OR13A1_uc001jcd.1_Missense_Mutation_p.P72R	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAAGTACATAGGAGCGTGGAG	0.517000													6	19					0	0	0.001984	0	0
POLR3A	11128	broad.mit.edu	37	10	79785906	79785906	+	Silent	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr10:79785906G>A	uc001jzn.2	-	2	220	c.126C>T	c.(124-126)TAC>TAT	p.Y42Y		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	42					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TGTCCTGGCTGTACAGGTTCT	0.532000													3	53					0	0	0.004672	0	0
XPNPEP1	7511	broad.mit.edu	37	10	111647887	111647887	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr10:111647887T>C	uc001kyp.1	-	7	583	c.443A>G	c.(442-444)GAG>GGG	p.E148G	XPNPEP1_uc009xxt.1_Missense_Mutation_p.E191G|XPNPEP1_uc001kyq.1_Missense_Mutation_p.E77G|XPNPEP1_uc010qrb.1_Missense_Mutation_p.E191G	NM_020383	NP_065116	Q9NQW7	XPP1_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 1,	148					bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			ovary(3)|pancreas(1)	4		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)		AACGAGGTTCTCCTTGACAGG	0.522000													5	17					0	0	0.000602	0	0
NLRP14	338323	broad.mit.edu	37	11	7061017	7061017	+	Splice_Site	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr11:7061017G>A	uc001mfb.1	+	3	684	c.361_splice	c.e3+1	p.G121_splice		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14						cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GCAGTGCTGGGTGAGTAGTTA	0.468000													5	114					0	0	0.000602	0	0
OR5L1	219437	broad.mit.edu	37	11	55579456	55579456	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr11:55579456A>G	uc001nhw.1	+	1	514	c.514A>G	c.(514-516)AAT>GAT	p.N172D		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				CTATAGATCTAATGTGATTAA	0.458000													5	219					0	0	0.001168	0	0
OR9G9	504191	broad.mit.edu	37	11	56468711	56468711	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr11:56468711T>G	uc010rjn.1	+	1	848	c.848T>G	c.(847-849)ATG>AGG	p.M283R		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTATTCCCCATGTTGAATCTC	0.388000													19	91					0	0	0.006122	0	0
OR9G4	283189	broad.mit.edu	37	11	56511045	56511045	+	Silent	SNP	C	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr11:56511045C>G	uc010rjo.1	-	1	243	c.243G>C	c.(241-243)CTG>CTC	p.L81L		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	81	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CCAAAAAAGACAGATTGCCAA	0.428000													12	76					0	0	0.001855	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64137197	64137197	+	Silent	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr11:64137197C>T	uc001oae.2	+	14	1712	c.1629C>T	c.(1627-1629)CCC>CCT	p.P543P	RPS6KA4_uc001oad.2_Silent_p.P537P|RPS6KA4_uc010rnl.1_Silent_p.P480P|RPS6KA4_uc001oaf.2_Silent_p.P536P|RPS6KA4_uc009ypp.2_Intron	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	543	Protein kinase 2.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						ACGACACGCCCGGGGCCCCGG	0.721000													3	19					0	0	0.004672	0	0
MALAT1	378938	broad.mit.edu	37	11	65265801	65265801	+	RNA	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr11:65265801C>T	uc010roh.1	+	1		c.569C>T				NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						TCCGTGCGGGCCGTGGGGGGC	0.617000													13	12					0	0	0.003163	0	0
SPCS2	9789	broad.mit.edu	37	11	74680630	74680630	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr11:74680630T>C	uc001ovu.2	+	4	419	c.380T>C	c.(379-381)ATT>ACT	p.I127T		NM_014752	NP_055567	Q15005	SPCS2_HUMAN	signal peptidase complex subunit 2 homolog	127	Helical; (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			breast(1)	1						ATGATGGGGATTCTGACCATT	0.378000													14	41					0	0	0.001855	0	0
RAB38	23682	broad.mit.edu	37	11	87883114	87883114	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr11:87883114C>A	uc001pcj.1	-	2	259	c.212G>T	c.(211-213)AGA>ATA	p.R71I		NM_022337	NP_071732	P57729	RAB38_HUMAN	RAB38	71					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GTTTCCAAATCTTTCTTGACC	0.383000													19	275					5.35267e-07	5.99757e-07	0.007413	1	0
ALX1	8092	broad.mit.edu	37	12	85677644	85677644	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr12:85677644C>T	uc001tae.3	+	2	525	c.521C>T	c.(520-522)GCC>GTC	p.A174V		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	174	Homeobox.				brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		CTCACTGAGGCCAGGGTCCAG	0.443000													18	82					0	0	0.004990	0	0
POSTN	10631	broad.mit.edu	37	13	38153417	38153417	+	Silent	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr13:38153417A>G	uc001uwo.3	-	13	1858	c.1740T>C	c.(1738-1740)GGT>GGC	p.G580G	POSTN_uc010tet.1_Silent_p.G108G|POSTN_uc001uwp.3_Silent_p.G580G|POSTN_uc001uwr.2_Silent_p.G580G|POSTN_uc001uwq.2_Silent_p.G580G|POSTN_uc010teu.1_Silent_p.G580G|POSTN_uc010tev.1_Silent_p.G580G|POSTN_uc010tew.1_Silent_p.G580G|POSTN_uc010tex.1_Silent_p.G495G	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	580	FAS1 4.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TGTTAGTAACACCAGGTTCAA	0.333000													11	29					0	0	0.008291	0	0
ESR2	2100	broad.mit.edu	37	14	64735545	64735545	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr14:64735545C>T	uc001xha.1	-	4	1088	c.620G>A	c.(619-621)CGG>CAG	p.R207Q	ESR2_uc001xgu.2_Missense_Mutation_p.R207Q|ESR2_uc001xgv.2_Missense_Mutation_p.R207Q|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Missense_Mutation_p.R207Q|ESR2_uc001xgy.1_Missense_Mutation_p.R207Q|ESR2_uc001xgz.1_Missense_Mutation_p.R207Q|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Missense_Mutation_p.R207Q	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	207	NR C4-type.|Nuclear receptor.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	GTAACACTTCCGAAGTCGGCA	0.448000													12	90					0	0	0.001855	0	0
TC2N	123036	broad.mit.edu	37	14	92268712	92268712	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr14:92268712G>T	uc001xzu.3	-	4	546	c.355C>A	c.(355-357)CAG>AAG	p.Q119K	TC2N_uc001xzt.3_Missense_Mutation_p.Q119K|TC2N_uc010auc.2_Missense_Mutation_p.Q119K|TC2N_uc001xzv.3_Missense_Mutation_p.Q119K	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	119						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		GGTCCGTGCTGGGATGAACTG	0.418000													14	62					0.000151284	0.00015988	0.001855	1	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652000													3	6					0	0	0.009096	0	0
CLDN6	9074	broad.mit.edu	37	16	3065807	3065807	+	Silent	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr16:3065807C>T	uc002csu.3	-	2	276	c.216G>A	c.(214-216)GCG>GCA	p.A72A		NM_021195	NP_067018	P56747	CLD6_HUMAN	claudin 6	72	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CCTGTGGCAGCGCCAGCAGTG	0.642000													22	28					0	0	0.010504	0	0
UBN1	29855	broad.mit.edu	37	16	4927426	4927426	+	Silent	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr16:4927426G>A	uc002cyb.2	+	17	3645	c.3306G>A	c.(3304-3306)GCG>GCA	p.A1102A	UBN1_uc010uxw.1_Intron|UBN1_uc002cyc.2_Silent_p.A1102A	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	1102					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						CCCATGCAGCGCCTCTCCCAC	0.592000													10	214					0	0	0.001855	0	0
TNRC6A	27327	broad.mit.edu	37	16	24802267	24802267	+	Silent	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr16:24802267T>C	uc002dmm.2	+	6	2418	c.2304T>C	c.(2302-2304)GAT>GAC	p.D768D	TNRC6A_uc010bxs.2_Silent_p.D515D|TNRC6A_uc010vcc.1_Silent_p.D515D|TNRC6A_uc002dmn.2_Silent_p.D515D|TNRC6A_uc002dmo.2_Silent_p.D515D	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	768	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		CATGTATAGATAAGACTAGCC	0.498000													10	34					0	0	0.013537	0	0
PDPR	55066	broad.mit.edu	37	16	70165240	70165240	+	Silent	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr16:70165240G>A	uc002eyf.1	+	8	1722	c.765G>A	c.(763-765)CCG>CCA	p.P255P	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Silent_p.P155P|PDPR_uc002eyg.1_5'Flank	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	255					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		ACGAGGAGCCGGTTAGTATCC	0.522000													3	3					0	0	0.000602	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348536	89348536	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr16:89348536C>T	uc002fmx.1	-	9	4875	c.4414G>A	c.(4414-4416)GAG>AAG	p.E1472K	ANKRD11_uc002fmy.1_Missense_Mutation_p.E1472K|ANKRD11_uc002fnc.1_Missense_Mutation_p.E1472K|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.E1429K	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1472	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		ctctccttctcgtctctccat	0.408000													10	31					0	0	0.006214	0	0
TP53	7157	broad.mit.edu	37	17	7578554	7578554	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr17:7578554A>C	uc002gim.2	-	5	570	c.376T>G	c.(376-378)TAC>GAC	p.Y126D	TP53_uc002gig.1_Missense_Mutation_p.Y126D|TP53_uc002gih.2_Missense_Mutation_p.Y126D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.Y126D|TP53_uc010cni.1_Missense_Mutation_p.Y126D|TP53_uc002gij.2_Missense_Mutation_p.Y126D|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y33D|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.Y87D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	126	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> C (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> G (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y126*(9)|p.0?(7)|p.Y126N(6)|p.Y126_K132delYSPALNK(6)|p.Y126C(4)|p.Y126D(3)|p.Y126_N131delYSPALN(3)|p.Y126S(2)|p.V73fs*9(1)|p.?(1)|p.Y126fs*24(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)|p.Y126Y(1)|p.Y126fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGGGAGTACTGTAGGAAG	0.557000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	15					0	0	0.003080	0	0
DNAH2	146754	broad.mit.edu	37	17	7662866	7662866	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr17:7662866C>T	uc002giu.1	+	15	2589	c.2575C>T	c.(2575-2577)CCA>TCA	p.P859S		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	859	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AAAGACCAGCCCAAACCCACT	0.502000													26	35					0	0	0.005443	0	0
DNAH9	1770	broad.mit.edu	37	17	11827172	11827172	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr17:11827172A>G	uc002gne.2	+	62	11859	c.11791A>G	c.(11791-11793)AAC>GAC	p.N3931D	DNAH9_uc010coo.2_Missense_Mutation_p.N3225D|DNAH9_uc002gnf.2_Missense_Mutation_p.N243D|DNAH9_uc010vvh.1_Missense_Mutation_p.N284D	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3931	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAACTTTCACAACGTGTCTTT	0.458000													11	53					0	0	0.008291	0	0
ULK2	9706	broad.mit.edu	37	17	19720091	19720091	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr17:19720091A>C	uc002gwm.3	-	13	1576	c.1067T>G	c.(1066-1068)GTG>GGG	p.V356G	ULK2_uc002gwn.2_Missense_Mutation_p.V356G	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	356					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GTTGTGTGGCACCAAAACAAA	0.398000													37	44					0	0	0.008740	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr17:39183145A>G	uc002hvu.2	-	1	310	c.263T>C	c.(262-264)ATC>ACC	p.I88T		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													3	24					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	17	45127107	45127107	+	Missense_Mutation	SNP	C	G	G	rs147409399	by1000genomes	TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr17:45127107C>G	uc010wkj.1	+	2	659	c.305C>G	c.(304-306)ACC>AGC	p.T102S	uc010wkl.1_RNA					SubName: Full=Putative uncharacterized protein LRRC37A3;																		CCTTCGTTCACCCAAGAGCAT	0.592000													3	64					0	0	0.004672	0	0
C18orf1	753	broad.mit.edu	37	18	13645353	13645353	+	Silent	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr18:13645353G>A	uc002ksa.2	+	7	1286	c.618G>A	c.(616-618)AGG>AGA	p.R206R	C18orf1_uc002ksb.2_Silent_p.R188R|C18orf1_uc002kse.2_Silent_p.R169R|C18orf1_uc002ksf.2_Silent_p.R151R|C18orf1_uc002ksg.1_Silent_p.R129R|C18orf1_uc002ksh.1_Silent_p.R148R|C18orf1_uc002ksi.1_Silent_p.R130R	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	206	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		AGTCCGTGAGGGCCCCACCCA	0.582000													8	71					0	0	0.004482	0	0
SERPINB7	8710	broad.mit.edu	37	18	61465877	61465877	+	Nonsense_Mutation	SNP	C	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr18:61465877C>A	uc002ljl.2	+	6	590	c.494C>A	c.(493-495)TCA>TAA	p.S165*	SERPINB7_uc002ljm.2_Nonsense_Mutation_p.S165*|SERPINB7_uc010xet.1_Nonsense_Mutation_p.S148*|SERPINB7_uc010dqg.2_Nonsense_Mutation_p.S165*	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	165					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				GGCATAAGCTCATCTGCTGTA	0.348000													6	86					8.12818e-05	8.68875e-05	0.001984	1	0
REEP6	92840	broad.mit.edu	37	19	1495534	1495534	+	Silent	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr19:1495534C>T	uc002ltc.2	+	3	380	c.276C>T	c.(274-276)TAC>TAT	p.Y92Y	REEP6_uc010xgp.1_Silent_p.Y92Y	NM_138393	NP_612402	Q96HR9	REEP6_HUMAN	receptor accessory protein 6	92	Helical; (Potential).					integral to membrane					0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTGGTGTACGCCCTGTTTG	0.622000													5	68					0	0	0.001168	0	0
PTPRS	5802	broad.mit.edu	37	19	5218496	5218496	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr19:5218496G>A	uc002mbv.2	-	25	4217	c.3983C>T	c.(3982-3984)GCC>GTC	p.A1328V	PTPRS_uc002mbu.1_Missense_Mutation_p.A897V|PTPRS_uc010xin.1_Missense_Mutation_p.A897V|PTPRS_uc002mbw.2_Missense_Mutation_p.A1306V|PTPRS_uc002mbx.2_Missense_Mutation_p.A901V|PTPRS_uc002mby.2_Missense_Mutation_p.A897V	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1328	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGCGAGGTCGGCATTGTTCAG	0.527000													5	251					0	0	0.001168	0	0
C3	718	broad.mit.edu	37	19	6678249	6678249	+	Silent	SNP	G	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr19:6678249G>T	uc002mfm.2	-	40	4826	c.4764C>A	c.(4762-4764)ATC>ATA	p.I1588I	C3_uc002mfl.2_Silent_p.I324I	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1588	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTCTGCACTTGATGGGGCTGA	0.587000													7	29					2.7689e-08	3.14033e-08	0.001984	1	0
MUC16	94025	broad.mit.edu	37	19	9070400	9070400	+	Silent	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr19:9070400G>A	uc002mkp.2	-	3	17250	c.17046C>T	c.(17044-17046)CCC>CCT	p.P5682P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AACTCGTTACGGGCTCTGGGC	0.512000													18	27					0	0	0.006122	0	0
ZNF833	401898	broad.mit.edu	37	19	11796444	11796444	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr19:11796444A>G	uc010dyg.2	+	3	1065	c.403A>G	c.(403-405)AGT>GGT	p.S135G	ZNF833_uc002msl.3_RNA	NM_001013691	NP_001013713			zinc finger protein 833												0						CACTTATCCCAGTGCCTTTCA	0.353000													18	26					0	0	0.006122	0	0
SLC17A7	57030	broad.mit.edu	37	19	49933968	49933968	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr19:49933968C>G	uc002pnp.2	-	12	1663	c.1491G>C	c.(1489-1491)TGG>TGC	p.W497C	SLC17A7_uc002pno.2_Missense_Mutation_p.W159C	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	497	Cytoplasmic (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		CAGGCTCTGCCCACGGCTGCT	0.587000													4	52					0	0	0.009096	0	0
TMEM150B	284417	broad.mit.edu	37	19	55828207	55828207	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr19:55828207A>G	uc010esw.1	-	7	625	c.452T>C	c.(451-453)ATT>ACT	p.I151T	TMEM150B_uc010yfu.1_Missense_Mutation_p.I151T|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	151	Cytoplasmic (Potential).					integral to membrane					0						GAGGGGCCCAATCCAGGCAGC	0.627000													2	2					0	0	0.004672	0	0
A1BG	1	broad.mit.edu	37	19	58863737	58863737	+	Silent	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr19:58863737A>G	uc002qsd.3	-	4	587	c.525T>C	c.(523-525)CAT>CAC	p.H175H	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	175	Ig-like V-type 2.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		TGCCAGGCTGATGGACTGGAA	0.622000													3	95					0	0	0.009096	0	0
THSD7B	80731	broad.mit.edu	37	2	138320879	138320879	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr2:138320879T>A	uc002tva.1	+	15	3140	c.3140T>A	c.(3139-3141)CTG>CAG	p.L1047Q	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AACAATGAGCTGAGGTCCCTG	0.443000													4	33					0	0	0.009096	0	0
SCN7A	6332	broad.mit.edu	37	2	167298214	167298214	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr2:167298214T>C	uc002udu.1	-	14	1976	c.1849A>G	c.(1849-1851)ATG>GTG	p.M617V	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	617					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AGAGACCACATCAAAATCTGG	0.383000													16	36					0	0	0.004007	0	0
COL3A1	1281	broad.mit.edu	37	2	189867065	189867065	+	Silent	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr2:189867065C>T	uc002uqj.1	+	35	2550	c.2433C>T	c.(2431-2433)TTC>TTT	p.F811F		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	811	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGCTGGTTTCCCTGGTGCTC	0.438000													4	39					0	0	0.000602	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								31	40					0	0	0.009535	0	0
NEU2	4759	broad.mit.edu	37	2	233899633	233899633	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr2:233899633C>A	uc010zmn.1	+	2	1009	c.1009C>A	c.(1009-1011)CTC>ATC	p.L337I		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	337							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CTACTCAGACCTCCAGAGCAT	0.607000													18	128					5.01169e-05	5.41962e-05	0.004990	1	0
AURKA	6790	broad.mit.edu	37	20	54956513	54956513	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr20:54956513C>A	uc002xxd.1	-	8	1247	c.681G>T	c.(679-681)AAG>AAT	p.K227N	AURKA_uc002xxe.1_Missense_Mutation_p.K227N|AURKA_uc002xxf.1_Missense_Mutation_p.K227N|AURKA_uc002xxg.1_Missense_Mutation_p.K227N|AURKA_uc002xxh.1_Missense_Mutation_p.K227N|AURKA_uc002xxi.1_Missense_Mutation_p.K227N|AURKA_uc002xxj.1_Missense_Mutation_p.K227N|AURKA_uc002xxk.1_Missense_Mutation_p.K227N|AURKA_uc010zzd.1_RNA	NM_198433	NP_940835	O14965	AURKA_HUMAN	serine/threonine protein kinase 6	227	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(1)|large_intestine(1)|skin(1)	8			Colorectal(105;0.202)			GCTCATCAAACTTTGAAAGTT	0.373000													15	81					9.16793e-09	1.05261e-08	0.004990	1	0
TPTE	7179	broad.mit.edu	37	21	10908895	10908895	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr21:10908895T>C	uc002yip.1	-	23	1818	c.1450A>G	c.(1450-1452)AAT>GAT	p.N484D	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.N466D|TPTE_uc002yir.1_Missense_Mutation_p.N446D|TPTE_uc010gkv.1_Missense_Mutation_p.N346D	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	484	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAGGAAGATTCTAAAAAGAA	0.254000													3	36					0	0	0.000602	0	0
IFNAR2	3455	broad.mit.edu	37	21	34625023	34625023	+	Silent	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr21:34625023G>A	uc002yrd.2	+	7	925	c.597G>A	c.(595-597)AAG>AAA	p.K199K	IFNAR2_uc002yrb.2_Silent_p.K199K|IFNAR2_uc002yrc.2_Silent_p.K199K|IFNAR2_uc002yre.2_Silent_p.K199K|IFNAR2_uc002yrf.2_Silent_p.K199K|IFNAR2_uc002yrg.2_Silent_p.K68K|IL10RB_uc002yrh.1_Silent_p.K49K|IL10RB_uc002yri.1_5'UTR	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	199	Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TCATTGACAAGTTAATTCCAA	0.353000													29	31					0	0	0.009535	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086744	46086744	+	Silent	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr21:46086744G>A	uc002zfu.2	-	1	101	c.60C>T	c.(58-60)TGC>TGT	p.C20C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181684	NP_859012	P59991	KR122_HUMAN	keratin associated protein 12-2	20	3.|23 X 5 AA approximate repeats.					keratin filament					0						AGGCTGGCTGGCAGGGGCTGG	0.667000													11	11					0	0	0.001855	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869695	22869695	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr22:22869695G>A	uc002zwe.2	-	2	513	c.260C>T	c.(259-261)TCG>TTG	p.S87L	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TGCAGGCTGCGACACGTGAGC	0.468000													21	90					0	0	0.002780	0	0
PPARG	5468	broad.mit.edu	37	3	12458613	12458613	+	Silent	SNP	C	T	T	rs148844673		TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr3:12458613C>T	uc003bwx.2	+	6	1321	c.1230C>T	c.(1228-1230)AGC>AGT	p.S410S	PPARG_uc003bwr.2_Silent_p.S382S|PPARG_uc003bws.2_Silent_p.S382S|PPARG_uc003bwu.2_Silent_p.S382S|PPARG_uc003bwv.2_Intron|PPARG_uc010hea.1_RNA	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	410	Ligand-binding.				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	TAGATGACAGCGACTTGGCAA	0.428000			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						7	44					0	0	0.001984	0	0
TFRC	7037	broad.mit.edu	37	3	195800987	195800987	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr3:195800987A>G	uc003fvz.3	-	4	531	c.248T>C	c.(247-249)ATT>ACT	p.I83T	TFRC_uc003fwa.3_Missense_Mutation_p.I83T|TFRC_uc010hzy.2_Missense_Mutation_p.I2T|TFRC_uc011btr.1_Intron	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	83	Helical; Signal-anchor for type II membrane protein; (Potential).				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		CAAGTAGCCAATCATAAATCC	0.423000			T	BCL6	NHL								11	45					0	0	0.008291	0	0
GPR125	166647	broad.mit.edu	37	4	22436987	22436987	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr4:22436987C>T	uc003gqm.1	-	10	1655	c.1390G>A	c.(1390-1392)GCA>ACA	p.A464T	GPR125_uc010ieo.1_Missense_Mutation_p.A338T|GPR125_uc003gqn.1_Missense_Mutation_p.A238T|GPR125_uc003gqo.2_Missense_Mutation_p.A464T	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	464	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				ATCATTTCTGCCACAAATATA	0.393000													11	49					0	0	0.008291	0	0
C6orf222	389384	broad.mit.edu	37	6	36290199	36290199	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr6:36290199G>A	uc003oly.2	-	9	1670	c.1492C>T	c.(1492-1494)CGG>TGG	p.R498W		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	498										skin(2)|ovary(1)|breast(1)	4						AGGGGCTCCCGGCACTCGAGA	0.567000													11	75					0	0	0.010729	0	0
TMEM63B	55362	broad.mit.edu	37	6	44116117	44116117	+	Silent	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr6:44116117C>T	uc003owr.2	+	13	1180	c.1116C>T	c.(1114-1116)ACC>ACT	p.T372T	TMEM63B_uc003owq.1_Silent_p.T372T|TMEM63B_uc003ows.2_Silent_p.T275T|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	372						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			AGACTATCACCGCCATGTGAG	0.592000													6	83					0	0	0.001984	0	0
FILIP1	27145	broad.mit.edu	37	6	76124523	76124523	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr6:76124523T>C	uc003pia.2	-	2	539	c.166A>G	c.(166-168)AAA>GAA	p.K56E	FILIP1_uc003phy.1_Missense_Mutation_p.K56E|FILIP1_uc010kbe.2_Missense_Mutation_p.K59E	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	56										skin(3)|ovary(1)	4						AGGTGTCGTTTGACAGTTCCT	0.403000													104	138					0	0	0.014410	0	0
ZNF292	23036	broad.mit.edu	37	6	87966561	87966561	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr6:87966561G>C	uc003plm.3	+	8	3255	c.3214G>C	c.(3214-3216)GCA>CCA	p.A1072P		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1072					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		AGAAAGTATTGCATTTGTTCC	0.373000													6	76					0	0	0.001984	0	0
FRK	2444	broad.mit.edu	37	6	116381413	116381413	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr6:116381413G>A	uc003pwi.1	-	1	509	c.62C>T	c.(61-63)ACG>ATG	p.T21M		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	21					negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		GTCTGCCTCCGTGGACAAACA	0.537000													9	110					0	0	0.013537	0	0
SLC22A2	6582	broad.mit.edu	37	6	160679569	160679569	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr6:160679569G>A	uc003qtf.2	-	1	391	c.221C>T	c.(220-222)ACG>ATG	p.T74M	SLC22A2_uc003qte.1_Missense_Mutation_p.T74M|SLC22A2_uc003qth.1_Missense_Mutation_p.T74M	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	74	Extracellular (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GCCCGGCACCGTGTAGTTCAG	0.672000													8	44					0	0	0.003080	0	0
WIPI2	26100	broad.mit.edu	37	7	5270498	5270498	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr7:5270498G>A	uc003snv.2	+	13	1501	c.1285G>A	c.(1285-1287)GCC>ACC	p.A429T	WIPI2_uc003snw.2_Missense_Mutation_p.A418T|WIPI2_uc003snx.2_Missense_Mutation_p.A411T|WIPI2_uc003sny.2_Missense_Mutation_p.A400T|WIPI2_uc010ksv.2_Missense_Mutation_p.A285T|WIPI2_uc003soa.2_Missense_Mutation_p.A359T|WIPI2_uc003sob.2_Missense_Mutation_p.A172T	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	429					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		TGTGGGTGGCGCCTGCCTGGA	0.612000													11	33					0	0	0.008291	0	0
ZDHHC4	55146	broad.mit.edu	37	7	6624735	6624735	+	Silent	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr7:6624735C>T	uc003sqi.2	+	8	943	c.585C>T	c.(583-585)CTC>CTT	p.L195L	ZDHHC4_uc003sql.2_Silent_p.L195L|ZDHHC4_uc003sqh.2_Silent_p.L195L|ZDHHC4_uc003sqj.2_Silent_p.L195L|ZDHHC4_uc003sqk.2_Silent_p.L195L|ZDHHC4_uc003sqm.2_Silent_p.L195L	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	195	DHHC-type.|Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		GGTACTTCCTCATCTACGTCT	0.527000													3	42					0	0	0.004672	0	0
COBL	23242	broad.mit.edu	37	7	51287614	51287614	+	Silent	SNP	T	G	G	rs145775268	by1000genomes	TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr7:51287614T>G	uc003tpr.3	-	2	254	c.69A>C	c.(67-69)CCA>CCC	p.P23P	COBL_uc003tps.2_Silent_p.P23P|COBL_uc011kcl.1_Silent_p.P23P|COBL_uc010kzc.2_Silent_p.P23P|COBL_uc003tpt.2_Silent_p.P23P	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	23	Poly-Pro.									skin(3)|ovary(2)	5	Glioma(55;0.08)					TTCCAGGAGGTGGGGGAGCAC	0.552000													4	36					0	0	0.000602	0	0
RP1	6101	broad.mit.edu	37	8	55541622	55541622	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr8:55541622A>G	uc003xsd.1	+	4	5328	c.5180A>G	c.(5179-5181)GAT>GGT	p.D1727G	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1727					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAACAAAATGATGATAGCAGA	0.393000													6	72					0	0	0.001168	0	0
XKR9	389668	broad.mit.edu	37	8	71646325	71646325	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr8:71646325A>G	uc003xyq.2	+	5	1322	c.788A>G	c.(787-789)TAT>TGT	p.Y263C	XKR9_uc010lze.2_Missense_Mutation_p.Y263C|XKR9_uc010lzd.2_Missense_Mutation_p.Y131C	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	263	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			GAATTCTTATATAGGATTGTT	0.289000													20	56					0	0	0.007413	0	0
NOTCH1	4851	broad.mit.edu	37	9	139413214	139413214	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr9:139413214C>T	uc004chz.2	-	6	928	c.928G>A	c.(928-930)GGG>AGG	p.G310R		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	310	Extracellular (Potential).|EGF-like 8; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.G310R(2)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TGGCAGGTCCCGCCGTTCTGG	0.627000			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			6	16					0	0	0.003080	0	0
FAM48B1	100130302	broad.mit.edu	37	X	24381605	24381605	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chrX:24381605C>T	uc011mjx.1	+	1	728	c.728C>T	c.(727-729)TCG>TTG	p.S243L		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						CAGAGGTATTCGTGGCCCTCT	0.507000													5	45					0	0	0.000602	0	0
DMD	1756	broad.mit.edu	37	X	32380909	32380909	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chrX:32380909C>T	uc004dda.1	-	37	5565	c.5321G>A	c.(5320-5322)GGA>GAA	p.G1774E	DMD_uc004dcw.2_Missense_Mutation_p.G430E|DMD_uc004dcx.2_Missense_Mutation_p.G433E|DMD_uc004dcz.2_Missense_Mutation_p.G1651E|DMD_uc004dcy.1_Missense_Mutation_p.G1770E|DMD_uc004ddb.1_Missense_Mutation_p.G1766E|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1774	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCCTACCTTTCCAGTCTTAAT	0.483000													16	26					0	0	0.004007	0	0
MCF2	4168	broad.mit.edu	37	X	138678852	138678852	+	Silent	SNP	T	C	C			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chrX:138678852T>C	uc004fau.2	-	19	2427	c.2133A>G	c.(2131-2133)ACA>ACG	p.T711T	MCF2_uc004fav.2_Silent_p.T727T|MCF2_uc011mwl.1_Silent_p.T688T|MCF2_uc010nsh.1_Silent_p.T711T|MCF2_uc011mwm.1_Silent_p.T672T|MCF2_uc011mwn.1_Silent_p.T856T|MCF2_uc004faw.2_Silent_p.T771T|MCF2_uc011mwo.1_Silent_p.T787T	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	711	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					CCTTCATTTTTGTAGCACCTT	0.398000													30	46					0	0	0.009535	0	0
ASCL4	121549	broad.mit.edu	37	12	108169502	108169502	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr12:108169502delG	uc001tmr.2	+	1	1341	c.510delG	c.(508-510)GAGfs	p.E170fs		NM_203436	NP_982260	Q6XD76	ASCL4_HUMAN	achaete-scute complex-like 4	169					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)	1						AGCCCGAGGAGGGGGGCAGCT	0.736													4	7	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7577081	7577099	+	Frame_Shift_Del	DEL	TCCTCTGTGCGCCGGTCTC	-	-	rs121912667	byFrequency	TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr17:7577081_7577099delTCCTCTGTGCGCCGGTCTC	uc002gim.2	-	8	1033_1051	c.839_857delGAGACCGGCGCACAGAGGA	c.(838-858)AGAGACCGGCGCACAGAGGAAfs	p.R280fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.R280fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.R148fs|TP53_uc010cng.1_Frame_Shift_Del_p.R148fs|TP53_uc002gii.1_Frame_Shift_Del_p.R148fs|TP53_uc010cnh.1_Frame_Shift_Del_p.R280fs|TP53_uc010cni.1_Frame_Shift_Del_p.R280fs|TP53_uc002gij.2_Frame_Shift_Del_p.R280fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280_286	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> G (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(366)|p.E285K(95)|p.R280T(53)|p.E286K(52)|p.R280K(41)|p.R282G(27)|p.D281E(25)|p.R283P(23)|p.R282Q(21)|p.D281H(19)|p.R280G(18)|p.D281N(18)|p.R283C(17)|p.E285*(16)|p.E286*(14)|p.R282P(14)|p.E286G(14)|p.E285V(13)|p.R280S(13)|p.R283H(12)|p.R280I(12)|p.D281G(10)|p.R282R(8)|p.R280*(8)|p.R280fs*65(7)|p.T284P(7)|p.0?(7)|p.E286V(6)|p.D281Y(6)|p.E286Q(5)|p.D281D(5)|p.E285Q(4)|p.R283R(4)|p.R283L(4)|p.R283fs*62(4)|p.E285E(3)|p.E285G(3)|p.T284T(3)|p.R282L(3)|p.R280R(3)|p.D281V(3)|p.T284A(3)|p.T284fs*61(3)|p.R283G(2)|p.E285A(2)|p.D281fs*63(2)|p.R282fs*24(2)|p.E286fs*59(2)|p.D281_R282>EW(2)|p.D281A(2)|p.T284fs*21(2)|p.R280_D281delRD(2)|p.R283fs*16(2)|p.E286fs*17(2)|p.T284fs*62(2)|p.R283fs*63(2)|p.?(2)|p.R283S(1)|p.G279fs*59(1)|p.D281_R282insXX(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.R282H(1)|p.R283fs*56(1)|p.E286A(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_N288delEEEN(1)|p.R283del(1)|p.R283fs*22(1)|p.V272_K292del21(1)|p.D281R(1)|p.E285fs*60(1)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.T284_G293del10(1)|p.D281fs*24(1)|p.E285fs*13(1)|p.T284I(1)|p.L265_K305del41(1)|p.R283_T284>T(1)|p.R282fs*63(1)|p.A276fs*64(1)|p.E285_L289delEEENL(1)|p.R282_E287delRRTEEE(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.T284fs*57(1)|p.D281_R282delDR(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGATTCTCTTCCTCTGTGCGCCGGTCTCTCCCAGGACA	0.553		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	48	---	---	---	---					
HCRTR2	3062	broad.mit.edu	37	6	55147128	55147128	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chr6:55147128delG	uc003pcl.2	+	7	1526	c.1211delG	c.(1210-1212)CGGfs	p.R404fs	HCRTR2_uc010jzv.2_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	404	Cytoplasmic (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ACAGAGAGCCGGAAGTCCTTG	0.483													12	25	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76939864	76939864	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DU-6399-01A-12D-1705-08	TCGA-DU-6399-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d386817-502d-4f0b-86a6-be6c07742c3a	b1f23f7a-9ecf-4f17-8692-dff4f56e41b9	g.chrX:76939864delT	uc004ecp.3	-	9	1116	c.884delA	c.(883-885)AAGfs	p.K295fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.K257fs|ATRX_uc004eco.3_Frame_Shift_Del_p.K80fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.K256fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.K295fs|ATRX_uc010nly.1_Frame_Shift_Del_p.K240fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	295	ADD.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TATCTTCTTCTTATTTTGCTG	0.348			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						85	11	---	---	---	---					
