Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CLCNKA	1187	broad.mit.edu	37	1	16352610	16352610	+	Silent	SNP	A	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:16352610A>G	uc001axu.2	+	5	446	c.366A>G	c.(364-366)GGA>GGG	p.G122G	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Silent_p.G122G|CLCNKA_uc010obw.1_Silent_p.G79G|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010obx.1_5'Flank|CLCNKA_uc010oby.1_5'Flank	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	122					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	AAGGTTCTGGAATCCCGGAGC	0.433000													49	338					0	0	0.139131	0	0
CROCCL1	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	T	T	rs367060		TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:16946434C>T	uc010ocf.1	-	3		c.464G>A			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						CTCAGCCTTCCGCCGGGCCAG	0.672000													4	40					0	0	0.029380	0	0
CROCCL1	84809	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	A	A	rs28392876	by1000genomes	TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:16946438G>A	uc010ocf.1	-	3		c.460C>T			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						GCCTTCCGCCGGGCCAGCAGC	0.672000													4	38					0	0	0.029380	0	0
MST1P2	11209	broad.mit.edu	37	1	16974243	16974243	+	RNA	SNP	G	C	C	rs142213352	by1000genomes	TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:16974243G>C	uc009vow.2	+	5		c.1053G>C			MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_Intron|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_Intron|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_Intron|MST1P2_uc001azm.3_Intron					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						GATCTCAGCTGTCGCTCGGGG	0.652000													5	35					0	0	0.029380	0	0
CAPN2	824	broad.mit.edu	37	1	223900426	223900426	+	Silent	SNP	C	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:223900426C>G	uc001hob.3	+	1	308	c.84C>G	c.(82-84)CTC>CTG	p.L28L	CAPN2_uc010puy.1_Intron	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	28					proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		TCAAGTACCTCAACCAGGACT	0.716000													9	16					0	0	0.093190	0	0
OR2T8	343172	broad.mit.edu	37	1	248084484	248084484	+	Silent	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:248084484G>A	uc010pzc.1	+	1	165	c.165G>A	c.(163-165)ACG>ACA	p.T55T		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCTCCACACGCCCATGTACT	0.522000													4	111					0	0	0.119110	0	0
OR2T12	127064	broad.mit.edu	37	1	248458716	248458716	+	Silent	SNP	C	T	T			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:248458716C>T	uc010pzj.1	-	1	165	c.165G>A	c.(163-165)AGG>AGA	p.R55R		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			AGTACATGGGCCTGTGGAGCC	0.527000													8	30					0	0	0.080935	0	0
OR51E1	143503	broad.mit.edu	37	11	4674358	4674358	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr11:4674358A>C	uc001lzi.3	+	2	746	c.602A>C	c.(601-603)TAT>TCT	p.Y201S		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		AATGTCGTCTATGGCCTTATC	0.493000													4	136					0	0	0.014758	0	0
OR10A4	283297	broad.mit.edu	37	11	6898019	6898019	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr11:6898019C>G	uc010rat.1	+	1	141	c.141C>G	c.(139-141)ATC>ATG	p.I47M		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCCTCATCATCCTGGTCACTA	0.453000													9	125					0	0	0.069234	0	0
MICALCL	84953	broad.mit.edu	37	11	12315446	12315446	+	Silent	SNP	A	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr11:12315446A>G	uc001mkg.1	+	3	759	c.468A>G	c.(466-468)AAA>AAG	p.K156K		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	156					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		ACCGGGAAAAAGGGAGTACTG	0.562000													3	37					0	0	0.115264	0	0
PAX6	5080	broad.mit.edu	37	11	31816308	31816308	+	Silent	SNP	T	C	C			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr11:31816308T>C	uc001mtd.3	-	7	1442	c.552A>G	c.(550-552)GGA>GGG	p.G184G	PAX6_uc001mte.3_Silent_p.G184G|PAX6_uc001mtg.3_Silent_p.G198G|PAX6_uc001mtf.3_Silent_p.G184G|PAX6_uc001mth.3_Silent_p.G184G|PAX6_uc009yjr.2_Silent_p.G184G	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	184	Gln/Gly-rich.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					TGGTATTCTCTCCCCCTCCTT	0.463000									Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				3	80					0	0	0.014758	0	0
MLL2	8085	broad.mit.edu	37	12	49443673	49443673	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr12:49443673T>C	uc001rta.3	-	11	3698	c.3698A>G	c.(3697-3699)GAG>GGG	p.E1233G		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1233					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCCACCCCCCTCCGGGTCTGG	0.587000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			3	86					0	0	0.150653	0	0
GLI1	2735	broad.mit.edu	37	12	57861814	57861814	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr12:57861814G>A	uc001snx.2	+	10	1193	c.1115G>A	c.(1114-1116)CGC>CAC	p.R372H	GLI1_uc009zpq.2_Missense_Mutation_p.R244H	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	372	C2H2-type 5.				epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TGCACCAAACGCTATACAGAT	0.542000													10	91					0	0	0.080935	0	0
RASL11A	387496	broad.mit.edu	37	13	27847183	27847183	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr13:27847183A>T	uc001urd.1	+	4	899	c.281A>T	c.(280-282)CAG>CTG	p.Q94L		NM_206827	NP_996563	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	94	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		AGCCTCCCCCAGGTCGTCGAT	0.498000													4	124					0	0	0.150653	0	0
TJP1	7082	broad.mit.edu	37	15	30001004	30001004	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr15:30001004G>A	uc001zcr.2	-	25	5084	c.4609C>T	c.(4609-4611)CGA>TGA	p.R1537*	TJP1_uc010azl.2_Nonsense_Mutation_p.R1525*|TJP1_uc001zcq.2_Nonsense_Mutation_p.R1461*|TJP1_uc001zcs.2_Nonsense_Mutation_p.R1457*	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1537					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TCAAATGGTCGGGCAGAACTT	0.403000													71	160					0	0	0.139131	0	0
GCNT3	9245	broad.mit.edu	37	15	59911328	59911328	+	Silent	SNP	G	A	A	rs139760962		TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr15:59911328G>A	uc002age.2	+	3	1340	c.891G>A	c.(889-891)GCG>GCA	p.A297A	GCNT3_uc002agd.2_Silent_p.A297A	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	297	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						CAGGGAATGCGTACATTGTGG	0.408000													21	146					0	0	0.083992	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	A	A	rs28934576	by1000genomes	TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr17:7577120C>A	uc002gim.2	-	8	1012	c.818G>T	c.(817-819)CGT>CTT	p.R273L	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141L|TP53_uc010cng.1_Missense_Mutation_p.R141L|TP53_uc002gii.1_Missense_Mutation_p.R141L|TP53_uc010cnh.1_Missense_Mutation_p.R273L|TP53_uc010cni.1_Missense_Mutation_p.R273L|TP53_uc002gij.2_Missense_Mutation_p.R273L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	10					1.5739e-10	1.60476e-10	0.146539	1	0
MAPK7	5598	broad.mit.edu	37	17	19283952	19283952	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr17:19283952C>G	uc002gvn.2	+	4	816	c.430C>G	c.(430-432)CTG>GTG	p.L144V	B9D1_uc010cqm.1_5'Flank|B9D1_uc002gvl.3_5'Flank|MAPK7_uc002gvo.2_Missense_Mutation_p.L5V|MAPK7_uc002gvq.2_Missense_Mutation_p.L144V|MAPK7_uc002gvp.2_Missense_Mutation_p.L144V	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	144	Necessary for oligomerization (By similarity).|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					GGAAAGCGACCTGCACCAGAT	0.582000													14	91					0	0	0.043863	0	0
MAPK7	5598	broad.mit.edu	37	17	19284535	19284535	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr17:19284535C>T	uc002gvn.2	+	4	1399	c.1013C>T	c.(1012-1014)GCA>GTA	p.A338V	MAPK7_uc002gvo.2_Missense_Mutation_p.A199V|MAPK7_uc002gvq.2_Missense_Mutation_p.A338V|MAPK7_uc002gvp.2_Missense_Mutation_p.A338V	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	338	Necessary for oligomerization (By similarity).|Poly-Ala.|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					CGCATCTCAGCAGCTGCTGCC	0.622000													6	72					0	0	0.021553	0	0
MYO18A	399687	broad.mit.edu	37	17	27434129	27434129	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr17:27434129C>T	uc002hdt.1	-	20	3568	c.3410G>A	c.(3409-3411)GGG>GAG	p.G1137E	MYO18A_uc010wbc.1_Missense_Mutation_p.G679E|MYO18A_uc002hds.2_Missense_Mutation_p.G679E|MYO18A_uc010csa.1_Missense_Mutation_p.G1137E|MYO18A_uc002hdu.1_Missense_Mutation_p.G1137E|MYO18A_uc010wbd.1_Missense_Mutation_p.G806E	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1137	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GTAGTTACGCCCGTGTTTCTT	0.612000													41	119					0	0	0.139131	0	0
ACE	1636	broad.mit.edu	37	17	61557164	61557164	+	Silent	SNP	C	T	T			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr17:61557164C>T	uc002jau.1	+	4	568	c.546C>T	c.(544-546)TAC>TAT	p.Y182Y	ACE_uc010wpi.1_Silent_p.Y182Y|ACE_uc010ddu.1_Translation_Start_Site	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	182	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CGCGAAGCTACGCCATGCTCC	0.592000													7	164					0	0	0.058154	0	0
FAM108A1	81926	broad.mit.edu	37	19	1881347	1881347	+	Silent	SNP	A	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr19:1881347A>G	uc002lug.2	-	2	625	c.219T>C	c.(217-219)CGT>CGC	p.R73R	FAM108A1_uc002lud.2_Silent_p.R73R|FAM108A1_uc002lue.2_Silent_p.R73R|FAM108A1_uc002luf.2_Silent_p.R73R	NM_001130111	NP_001123583	Q96GS6	F18A1_HUMAN	hypothetical protein LOC81926 isoform 2	73						extracellular region	hydrolase activity				0		Ovarian(11;0.000137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGTCGGCACGCTCCGTCA	0.716000													4	71					0	0	0.021553	0	0
ZNF83	55769	broad.mit.edu	37	19	53116804	53116804	+	Silent	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr19:53116804G>A	uc002pzu.3	-	2	2258	c.1014C>T	c.(1012-1014)ATC>ATT	p.I338I	ZNF83_uc002pzv.3_Silent_p.I338I|ZNF83_uc010eps.2_Silent_p.I310I|ZNF83_uc010ept.2_Silent_p.I338I|ZNF83_uc010epu.2_Silent_p.I338I|ZNF83_uc010epv.2_Silent_p.I338I|ZNF83_uc010epw.2_Silent_p.I338I|ZNF83_uc010epx.2_Silent_p.I310I|ZNF83_uc010epy.2_Silent_p.I338I|ZNF83_uc010epz.2_Silent_p.I310I	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	338	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		CTCCAGTGTGGATTCTCCAGT	0.413000													4	113					0	0	0.150653	0	0
DYNC2LI1	51626	broad.mit.edu	37	2	44028017	44028017	+	Missense_Mutation	SNP	G	A	A	rs141895414		TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr2:44028017G>A	uc002rtk.2	+	9	788	c.692G>A	c.(691-693)CGT>CAT	p.R231H	DYNC2LI1_uc002rtj.2_Missense_Mutation_p.R231H|DYNC2LI1_uc002rtl.2_Missense_Mutation_p.R232H|DYNC2LI1_uc010ynz.1_Missense_Mutation_p.R105H	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	231						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTAAAAATACGTGGAGTTATC	0.313000													5	37					0	0	0.021553	0	0
FAHD2A	51011	broad.mit.edu	37	2	96071501	96071501	+	Silent	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr2:96071501G>A	uc002sur.2	+	2	374	c.195G>A	c.(193-195)ACG>ACA	p.T65T	FAHD2A_uc002sus.2_Silent_p.T65T	NM_016044	NP_057128	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing	65							hydrolase activity|metal ion binding			ovary(1)	1						TCCCGAAGACGATGACGCAGT	0.617000													7	27					0	0	0.047766	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								21	58					0	0	0.083992	0	0
HIC2	23119	broad.mit.edu	37	22	21799992	21799992	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr22:21799992G>A	uc002zur.3	+	3	1038	c.808G>A	c.(808-810)GCA>ACA	p.A270T	HIC2_uc002zus.3_Missense_Mutation_p.A270T	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	270					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				TCCCGATGACGCAGCCCAGCT	0.672000													4	162					0	0	0.014758	0	0
XIRP1	165904	broad.mit.edu	37	3	39227182	39227182	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr3:39227182G>A	uc003cjk.1	-	2	3976	c.3755C>T	c.(3754-3756)GCC>GTC	p.A1252V	XIRP1_uc003cji.2_Intron|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1252	Pro-rich.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AGGAACAAAGGCATTATGGGG	0.622000													10	25					0	0	0.058154	0	0
LOC285359	285359	broad.mit.edu	37	3	101431934	101431934	+	RNA	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr3:101431934G>A	uc003dvj.2	+	1		c.657G>A				NR_002941				Homo sapiens cDNA FLJ12205 fis, clone MAMMA1000931.												0						AATTATGATGGACCTGGAGGA	0.473000													5	67					0	0	0.029380	0	0
TRH	7200	broad.mit.edu	37	3	129695840	129695840	+	Silent	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr3:129695840G>A	uc003enc.2	+	3	1071	c.510G>A	c.(508-510)GAG>GAA	p.E170E		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	170					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						Gggaagaagaggaggaggagg	0.547000													4	64					0	0	0.150653	0	0
DLG1	1739	broad.mit.edu	37	3	196812552	196812552	+	Silent	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr3:196812552G>A	uc003fxo.3	-	17	2026	c.1836C>T	c.(1834-1836)ATC>ATT	p.I612I	DLG1_uc011bub.1_Silent_p.I496I|DLG1_uc011buc.1_Silent_p.I496I|DLG1_uc011bud.1_Silent_p.I295I|DLG1_uc003fxn.3_Silent_p.I612I|DLG1_uc011bue.1_Silent_p.I579I|DLG1_uc010ial.2_Silent_p.I612I|DLG1_uc011buf.1_RNA|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Silent_p.I579I	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	612	SH3.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TAACATGGAGGATATCTCCAA	0.448000													6	97					0	0	0.021553	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr4:71346978T>C	uc011cat.1	+	4	805	c.517T>C	c.(517-519)TCT>CCT	p.S173P	MUC7_uc011cau.1_Missense_Mutation_p.S173P|MUC7_uc003hfj.2_Missense_Mutation_p.S173P|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	173	1.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													5	284					0	0	0.069234	0	0
MUC7	4589	broad.mit.edu	37	4	71347185	71347185	+	Missense_Mutation	SNP	T	C	C	rs79807294	by1000genomes	TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr4:71347185T>C	uc011cat.1	+	4	1012	c.724T>C	c.(724-726)TCT>CCT	p.S242P	MUC7_uc011cau.1_Missense_Mutation_p.S242P|MUC7_uc003hfj.2_Missense_Mutation_p.S242P|uc011cav.1_Intron	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	242	Thr-rich.|4.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.592000													6	385					0	0	0.080935	0	0
PRSS12	8492	broad.mit.edu	37	4	119252936	119252936	+	Silent	SNP	T	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr4:119252936T>G	uc003ica.1	-	4	953	c.906A>C	c.(904-906)GGA>GGC	p.G302G		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	302	SRCR 2.					membrane	scavenger receptor activity			skin(1)	1						CACAAACGGTTCCCCACTGGC	0.527000													9	155					0	0	0.058154	0	0
UNC5A	90249	broad.mit.edu	37	5	176289826	176289826	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr5:176289826G>A	uc003mey.2	+	2	464	c.272G>A	c.(271-273)CGC>CAC	p.R91H	UNC5A_uc003mex.1_Missense_Mutation_p.R91H|UNC5A_uc010jkg.1_5'UTR	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	91	Ig-like.|Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGATCGAGCGCAGCACAGAC	0.677000													5	321					0	0	0.029380	0	0
KDM1B	221656	broad.mit.edu	37	6	18218071	18218071	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr6:18218071T>G	uc003nco.1	+	14	1806	c.1731T>G	c.(1729-1731)GAT>GAG	p.D577E	KDM1B_uc003ncn.1_Missense_Mutation_p.D548E|KDM1B_uc003ncp.1_Missense_Mutation_p.D133E|KDM1B_uc003ncq.1_Missense_Mutation_p.D133E	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	780					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						AGGCCTACGATATCATTGCTG	0.428000													4	81					0	0	0.150653	0	0
HIST1H2BB	3018	broad.mit.edu	37	6	26043861	26043861	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr6:26043861G>C	uc003nfu.2	-	1	25	c.25C>G	c.(25-27)CCA>GCA	p.P9A	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	9					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TTAGGGGCTGGAGCAGACTTA	0.458000													4	46					0	0	0.150653	0	0
TFEB	7942	broad.mit.edu	37	6	41658430	41658430	+	Silent	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr6:41658430G>A	uc003oqs.1	-	4	741	c.439C>T	c.(439-441)CTG>TTG	p.L147L	TFEB_uc003oqt.1_Silent_p.L147L|TFEB_uc003oqu.1_Silent_p.L161L|TFEB_uc003oqv.1_Silent_p.L147L|TFEB_uc010jxo.1_Silent_p.L147L|TFEB_uc003oqx.1_Silent_p.L147L|TFEB_uc003oqr.1_Intron|TFEB_uc003oqw.1_Silent_p.L147L	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	147					embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			CCAATGTGCAGCATGGCCATG	0.642000			T	ALPHA	renal (childhood epithelioid)								3	59					0	0	0.115264	0	0
RUNX2	860	broad.mit.edu	37	6	45390463	45390463	+	Silent	SNP	G	A	A			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr6:45390463G>A	uc011dvx.1	+	3	402	c.192G>A	c.(190-192)CAG>CAA	p.Q64Q	RUNX2_uc011dvy.1_Silent_p.Q64Q|RUNX2_uc003oxt.2_Silent_p.Q50Q	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	64	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						agcagcagcagcaacagcagc	0.279000													4	34					0	0	0.014758	0	0
RUNX2	860	broad.mit.edu	37	6	45390466	45390466	+	Silent	SNP	A	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr6:45390466A>G	uc011dvx.1	+	3	405	c.195A>G	c.(193-195)CAA>CAG	p.Q65Q	RUNX2_uc011dvy.1_Silent_p.Q65Q|RUNX2_uc003oxt.2_Silent_p.Q51Q	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	65	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						agcagcagcaacagcagcagc	0.274000													3	31					0	0	0.014758	0	0
PSD3	23362	broad.mit.edu	37	8	18432755	18432755	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr8:18432755A>G	uc003wza.2	-	13	2625	c.2522T>C	c.(2521-2523)TTG>TCG	p.L841S	PSD3_uc003wyx.3_Missense_Mutation_p.L170S|PSD3_uc003wyy.2_Missense_Mutation_p.L307S|PSD3_uc003wyz.2_Missense_Mutation_p.L142S	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	842	PH.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		AGCGTTTTTCAAGTCCTCTTC	0.418000													3	69					0	0	0.115264	0	0
ATRX	546	broad.mit.edu	37	X	76814188	76814188	+	Nonsense_Mutation	SNP	A	C	C			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chrX:76814188A>C	uc004ecp.3	-	29	6688	c.6456T>G	c.(6454-6456)TAT>TAG	p.Y2152*	ATRX_uc004ecq.3_Nonsense_Mutation_p.Y2114*|ATRX_uc004eco.3_Nonsense_Mutation_p.Y1937*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2152	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GTCCAAAGCGATAAACTCTGA	0.338000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						7	36					0	0	0.058154	0	0
CASZ1	54897	broad.mit.edu	37	1	10699141	10699146	+	In_Frame_Del	DEL	TCGTCG	-	-			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:10699141_10699146delTCGTCG	uc001aro.2	-	21	5453_5458	c.5133_5138delCGACGA	c.(5131-5139)GACGACGAG>GAG	p.DD1711del		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1711_1712	Asp-rich.|Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GCGCAGgtcctcgtcgtcgtcgtcct	0.117													7	6	---	---	---	---					
PHACTR4	65979	broad.mit.edu	37	1	28800272	28800273	+	Frame_Shift_Ins	INS	-	C	C			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:28800272_28800273insC	uc001bpw.2	+	7	1312_1313	c.1030_1031insC	c.(1030-1032)TCCfs	p.S344fs	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Frame_Shift_Ins_p.S328fs|PHACTR4_uc001bpy.2_Frame_Shift_Ins_p.S354fs	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	344	Pro-rich.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCGCTCTCCGTCCCCCCCACTG	0.515													7	447	---	---	---	---					
WDR78	79819	broad.mit.edu	37	1	67390426	67390426	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr1:67390426delT	uc001dcx.2	-	1	145	c.89delA	c.(88-90)AAGfs	p.K30fs	WDR78_uc001dcy.2_Frame_Shift_Del_p.K30fs|WDR78_uc001dcz.2_Frame_Shift_Del_p.K30fs|MIER1_uc001dda.3_5'Flank|MIER1_uc010opf.1_5'Flank|MIER1_uc009way.2_5'Flank|MIER1_uc001ddc.2_5'Flank|MIER1_uc001ddh.2_5'Flank|MIER1_uc001ddf.2_5'Flank|MIER1_uc001ddg.2_5'Flank|MIER1_uc010opg.1_5'Flank|MIER1_uc001dde.2_5'Flank	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	30										ovary(2)	2						GCACCACCCCTTTTTTTGGCC	0.622													7	222	---	---	---	---					
PCDH15	65217	broad.mit.edu	37	10	55587198	55587200	+	In_Frame_Del	DEL	GGC	-	-	rs12246234		TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr10:55587198_55587200delGGC	uc001jju.1	-	32	4715_4717	c.4320_4322delGCC	c.(4318-4323)CCGCCT>CCT	p.1440_1441PP>P	PCDH15_uc010qhq.1_In_Frame_Del_p.1445_1446PP>P|PCDH15_uc010qhr.1_In_Frame_Del_p.1440_1441PP>P|PCDH15_uc010qhs.1_In_Frame_Del_p.1452_1453PP>P|PCDH15_uc010qht.1_In_Frame_Del_p.1447_1448PP>P|PCDH15_uc010qhu.1_In_Frame_Del_p.1440_1441PP>P|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_In_Frame_Del_p.1437_1438PP>P|PCDH15_uc010qhw.1_In_Frame_Del_p.1400_1401PP>P|PCDH15_uc010qhx.1_In_Frame_Del_p.1369_1370PP>P|PCDH15_uc010qhy.1_In_Frame_Del_p.1445_1446PP>P|PCDH15_uc010qhz.1_In_Frame_Del_p.1440_1441PP>P|PCDH15_uc010qia.1_In_Frame_Del_p.1418_1419PP>P|PCDH15_uc010qib.1_In_Frame_Del_p.1415_1416PP>P	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1440_1441	Poly-Pro.|Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACCTggcggaggcggcggcggcg	0.438										HNSCC(58;0.16)			7	225	---	---	---	---					
KRT1	3848	broad.mit.edu	37	12	53069236	53069256	+	In_Frame_Del	DEL	TAGCTGCTACCTCCGGAGCCA	-	-	rs66529359		TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr12:53069236_53069256delTAGCTGCTACCTCCGGAGCCA	uc001sau.1	-	9	1715_1735	c.1656_1676delTGGCTCCGGAGGTAGCAGCTA	c.(1654-1677)TATGGCTCCGGAGGTAGCAGCTAC>TAC	p.552_559YGSGGSSY>Y	KRT1_uc001sav.1_Splice_Site_p.G556_splice	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	552_559	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						tccggagccgtagctgctacctccggagccatagctgccac	0.000													3	4	---	---	---	---					
ZIC2	7546	broad.mit.edu	37	13	100635008	100635010	+	In_Frame_Del	DEL	CCA	-	-			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr13:100635008_100635010delCCA	uc001von.2	+	1	690_692	c.690_692delCCA	c.(688-693)GCCCAC>GCC	p.H239del		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	239	Necessary for interaction with MDFIC and transcriptional activation or repression (By similarity).|Poly-His.		Missing.|H -> HH.		brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAGCCGCGGCccaccaccaccac	0.522													7	116	---	---	---	---					
MED9	55090	broad.mit.edu	37	17	17394705	17394707	+	In_Frame_Del	DEL	CAG	-	-			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr17:17394705_17394707delCAG	uc002grh.1	+	2	393_395	c.337_339delCAG	c.(337-339)CAGdel	p.Q117del		NM_018019	NP_060489	Q9NWA0	MED9_HUMAN	mediator complex subunit 9	117	Potential.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		protein binding				0						GAGCCCCGAACAGCAGCAGCAGC	0.581													7	175	---	---	---	---					
TCF20	6942	broad.mit.edu	37	22	42610573	42610575	+	In_Frame_Del	DEL	AGG	-	-			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr22:42610573_42610575delAGG	uc003bcj.1	-	1	871_873	c.737_739delCCT	c.(736-741)TCCTTC>TTC	p.S246del	TCF20_uc003bck.1_In_Frame_Del_p.S246del|TCF20_uc003bnt.2_In_Frame_Del_p.S246del	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	246	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GGTGAAGGGAaggaggaggagga	0.438													11	113	---	---	---	---					
IRX4	50805	broad.mit.edu	37	5	1879669	1879671	+	In_Frame_Del	DEL	CCT	-	-			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr5:1879669_1879671delCCT	uc003jcz.2	-	4	802_804	c.683_685delAGG	c.(682-687)GAGGGG>GGG	p.E228del	IRX4_uc011cmf.1_In_Frame_Del_p.E89del	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	228	Poly-Glu.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		tcctcgcccccctcctcctcctc	0.507													7	52	---	---	---	---					
BTN2A3	54718	broad.mit.edu	37	6	26422388	26422390	+	In_Frame_Del	DEL	CCT	-	-	rs113134648		TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr6:26422388_26422390delCCT	uc011dkl.1	+	1	72_74	c.42_44delCCT	c.(40-45)TCCCTC>TCC	p.L19del	BTN2A3_uc011dkm.1_RNA					RecName: Full=Butyrophilin subfamily 2 member A3; Flags: Precursor;												0						GGCCAGCCTCCCTCCTCCTCCTC	0.586													17	429	---	---	---	---					
STK19	8859	broad.mit.edu	37	6	31939825	31939826	+	Frame_Shift_Ins	INS	-	G	G			TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr6:31939825_31939826insG	uc003nyv.2	+	1	180_181	c.52_53insG	c.(52-54)CGGfs	p.R18fs	DOM3Z_uc003nyo.1_5'UTR|DOM3Z_uc003nyp.1_5'UTR|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_5'UTR|DOM3Z_uc003nys.1_5'Flank|DOM3Z_uc010jtl.1_5'UTR|STK19_uc003nyt.2_5'UTR|DOM3Z_uc003nyu.1_5'UTR|STK19_uc011dow.1_Frame_Shift_Ins_p.R18fs|STK19_uc011dox.1_5'UTR|STK19_uc003nyw.2_Frame_Shift_Ins_p.R18fs|STK19_uc010jtn.1_5'Flank	NM_032454	NP_115830	P49842	STK19_HUMAN	serine/threonine kinase 19 isoform 2	18						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(4)	4						GCGACAGTGGCGGGCAAACCCC	0.634													8	381	---	---	---	---					
POM121	9883	broad.mit.edu	37	7	72413723	72413724	+	In_Frame_Ins	INS	-	CTC	CTC	rs148686669	byFrequency	TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr7:72413723_72413724insCTC	uc003twk.2	+	11	3191_3192	c.3191_3192insCTC	c.(3190-3192)TTC>TTCTCC	p.1064_1065insS	POM121_uc003twj.2_In_Frame_Ins_p.799_800insS|POM121_uc010lam.1_In_Frame_Ins_p.799_800insS	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1064_1065	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				ACTGCTGTCTTCTTCGGTGCAG	0.663													7	118	---	---	---	---					
PABPC1	26986	broad.mit.edu	37	8	101721933	101721933	+	Frame_Shift_Del	DEL	T	-	-	rs112966887		TCGA-DU-8163-01A-11D-2253-08	TCGA-DU-8163-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a240da2-0f4a-4b1c-b220-b220ad4d5749	216b595d-09da-487c-b319-fc9748c68efd	g.chr8:101721933delT	uc003yjs.1	-	8	1503	c.999delA	c.(997-999)AAAfs	p.K333fs	PABPC1_uc011lhc.1_Frame_Shift_Del_p.K301fs|PABPC1_uc011lhd.1_Frame_Shift_Del_p.K288fs|PABPC1_uc003yjt.1_Frame_Shift_Del_p.K330fs|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	333	RRM 4.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			AACCAAACCCTTTGCTGCGAC	0.383													8	52	---	---	---	---					
