Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
EPHA10	284656	broad.mit.edu	37	1	38227727	38227727	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:38227727T>C	uc009vvi.2	-	3	286	c.200A>G	c.(199-201)CAC>CGC	p.H67R	EPHA10_uc001cbw.3_Missense_Mutation_p.H67R	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	67	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGGACGGTCGTGTTCATCCAC	0.627													35	92					0	0	0.019004	0	0
SFRS11	9295	broad.mit.edu	37	1	70712575	70712575	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:70712575C>G	uc001des.2	+	10	1131	c.1007C>G	c.(1006-1008)TCT>TGT	p.S336C	SFRS11_uc001det.2_Missense_Mutation_p.S336C|SFRS11_uc001deu.2_Missense_Mutation_p.S336C|SFRS11_uc001dev.2_Missense_Mutation_p.S146C|SFRS11_uc001dew.2_Missense_Mutation_p.S276C	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	336	9.|10 X 8 AA approximate repeats of R-R-S-R- S-R-S-R.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						GCCAGACGTTCTAGAAGTGCA	0.348													7	93					0	0	0.004482	0	0
RPTN	126638	broad.mit.edu	37	1	152129014	152129014	+	Silent	SNP	T	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:152129014T>C	uc001ezs.1	-	3	626	c.561A>G	c.(559-561)AGA>AGG	p.R187R		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	187	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						CCTTGTCTTGTCTCTCAGACT	0.458													16	500					0	0	0.006122	0	0
TDRD10	126668	broad.mit.edu	37	1	154516509	154516509	+	Missense_Mutation	SNP	G	A	A	rs143192137	byFrequency	TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:154516509G>A	uc009wow.2	+	9	1412	c.574G>A	c.(574-576)GTC>ATC	p.V192I	TDRD10_uc001ffd.2_Missense_Mutation_p.V192I|TDRD10_uc001ffe.2_Missense_Mutation_p.V113I	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	192							nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CATCCATAGCGTCCGTGGGGA	0.612													47	126					0	0	0.014410	0	0
GLT25D2	23127	broad.mit.edu	37	1	183938503	183938503	+	Silent	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:183938503C>T	uc001gqr.2	-	5	1104	c.732G>A	c.(730-732)AGG>AGA	p.R244R	GLT25D2_uc010poj.1_Silent_p.R244R|GLT25D2_uc001gqs.2_Silent_p.R124R	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	244					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						AGGCCTCCTTCCTGAGGTCAA	0.537													42	128					0	0	0.014410	0	0
KIF26B	55083	broad.mit.edu	37	1	245862231	245862231	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:245862231C>T	uc001ibf.1	+	14	6510	c.6070C>T	c.(6070-6072)CGC>TGC	p.R2024C		NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	2024					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R2024H(1)		ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TCTGGAACACCGCCAGCAGAG	0.567													18	49					0	0	0.010504	0	0
OR11L1	391189	broad.mit.edu	37	1	248004441	248004441	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:248004441C>A	uc001idn.1	-	1	758	c.758G>T	c.(757-759)GGG>GTG	p.G253V		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GATCATGGTCCCGTAGTAGAG	0.498													28	74					2.28855e-06	2.40531e-06	0.019004	1	0
OR2G6	391211	broad.mit.edu	37	1	248685648	248685648	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:248685648G>A	uc001ien.1	+	1	701	c.701G>A	c.(700-702)CGC>CAC	p.R234H		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTGCGGGCCGCCAAAAGGCC	0.473													30	66					0	0	0.008361	0	0
OR52I2	143502	broad.mit.edu	37	11	4608347	4608347	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr11:4608347T>C	uc010qyh.1	+	1	305	c.305T>C	c.(304-306)GTT>GCT	p.V102A		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	102	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTGGACATTGTTATGGCCTCC	0.483													65	166					0	0	0.014410	0	0
OR51A2	401667	broad.mit.edu	37	11	4976474	4976474	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr11:4976474A>T	uc010qyt.1	-	1	470	c.470T>A	c.(469-471)CTG>CAG	p.L157Q		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGGAAGAACCAGGAGCATGCT	0.438													16	98					0	0	0.008871	0	0
OR52E8	390079	broad.mit.edu	37	11	5878650	5878650	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr11:5878650T>C	uc010qzr.1	-	1	283	c.283A>G	c.(283-285)ACC>GCC	p.T95A	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTTCTTTGGTATTGAACCAG	0.473													54	90					0	0	0.014410	0	0
ANO1	55107	broad.mit.edu	37	11	69950226	69950226	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr11:69950226C>T	uc001opj.2	+	4	967	c.662C>T	c.(661-663)TCC>TTC	p.S221F	ANO1_uc001opk.1_Missense_Mutation_p.S193F|ANO1_uc001opl.1_RNA	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	221	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						AAGAGACTCTCCTATCCCTTC	0.542													4	6					0	0	0.014758	0	0
SHANK2	22941	broad.mit.edu	37	11	70319315	70319315	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr11:70319315G>C	uc001oqc.2	-	22	5287	c.5209C>G	c.(5209-5211)CTC>GTC	p.L1737V	SHANK2_uc010rqn.1_Missense_Mutation_p.L1149V|SHANK2_uc001opz.2_Missense_Mutation_p.L1142V|uc009ysn.1_Missense_Mutation_p.R72T|SHANK2_uc001opy.2_Missense_Mutation_p.L73V	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1358					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACATCTGAGAGAGCGGGAGAA	0.602													31	60					0	0	0.007835	0	0
MMP8	4317	broad.mit.edu	37	11	102587093	102587093	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr11:102587093G>T	uc001phe.2	-	6	941	c.842C>A	c.(841-843)CCC>CAC	p.P281H	MMP8_uc010rut.1_Missense_Mutation_p.P216H|MMP8_uc010ruu.1_Missense_Mutation_p.P258H	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	281					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		TGTCAAACTGGGGTCACAGGG	0.363													33	60					1.4374e-25	1.78376e-25	0.014410	1	0
Unknown	0	broad.mit.edu	37	12	31353359	31353359	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr12:31353359T>A	uc010sjy.1	-	3	371	c.371A>T	c.(370-372)AAA>ATA	p.K124I						RecName: Full=Ovostatin homolog 1; Flags: Precursor;																		ACACTCACCTTTCTGTCCAGG	0.398													4	18					0	0	0.014758	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43822162	43822162	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr12:43822162T>A	uc010skx.1	-	26	3827	c.3827A>T	c.(3826-3828)CAG>CTG	p.Q1276L	ADAMTS20_uc001rno.1_Missense_Mutation_p.Q394L|ADAMTS20_uc001rnp.1_Missense_Mutation_p.Q430L	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1276						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ATAGCTTGGCTGCACAGGGGA	0.468													4	74					0	0	0.014758	0	0
OR9K2	441639	broad.mit.edu	37	12	55524375	55524375	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr12:55524375G>A	uc010spe.1	+	1	823	c.823G>A	c.(823-825)GTG>ATG	p.V275M		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	275	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						AGTTGTGAGTGTGCTGTATGG	0.438													25	115					0	0	0.006320	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85521757	85521757	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr12:85521757A>T	uc001tac.2	+	18	4266	c.4155A>T	c.(4153-4155)AGA>AGT	p.R1385S		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1385										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		AAGGAAAAAGAGAAAATATTG	0.353													11	78					0	0	0.008291	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124228804	124228804	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr12:124228804G>A	uc001ufr.2	+	11	1494	c.1246G>A	c.(1246-1248)GGA>AGA	p.G416R		NM_012463	NP_036595	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	416	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		TGGAGACTTCGGACATGGCTT	0.373													28	82					0	0	0.008361	0	0
LOC647288	647288	broad.mit.edu	37	13	75814384	75814384	+	Silent	SNP	C	T	T	rs1888257	by1000genomes	TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr13:75814384C>T	uc010ths.1	-	1	134	c.93G>A	c.(91-93)ACG>ACA	p.T31T		NR_027466				Homo sapiens mRNA; cDNA DKFZp434F0327 (from clone DKFZp434F0327).												0						TCGAATCTGCCGTCATACTCT	0.507													3	48					0	0	0.004672	0	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr13:115047559C>T	uc001vup.2	+	2	308	c.271C>T	c.(271-273)CTG>TTG	p.L91L	UPF3A_uc010tkn.1_Silent_p.L91L|UPF3A_uc001vuq.2_Silent_p.L91L|UPF3A_uc001vus.2_RNA|UPF3A_uc001vur.2_RNA	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731													3	3					0	0	0.004672	0	0
ERO1L	30001	broad.mit.edu	37	14	53138414	53138414	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr14:53138414T>C	uc001wzv.2	-	6	668	c.442A>G	c.(442-444)ACA>GCA	p.T148A	ERO1L_uc001wzw.2_RNA|ERO1L_uc010aof.2_RNA	NM_014584	NP_055399	Q96HE7	ERO1A_HUMAN	ERO1-like precursor	148					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor				0	Breast(41;0.226)					GCCTTCTGTGTTTCCTCACTT	0.284													20	9					0	0	0.016522	0	0
DMXL2	23312	broad.mit.edu	37	15	51773679	51773679	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr15:51773679T>C	uc002abf.2	-	24	5849	c.5624A>G	c.(5623-5625)GAT>GGT	p.D1875G	DMXL2_uc002abd.2_5'UTR|DMXL2_uc010ufy.1_Missense_Mutation_p.D1875G|DMXL2_uc010bfa.2_Missense_Mutation_p.D1239G	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1875						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GTTAATTTTATCAACAAAGTT	0.378													6	41					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	15	102291827	102291827	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr15:102291827G>C	uc010usj.1	+	3	194	c.135G>C	c.(133-135)CAG>CAC	p.Q45H	uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;																		AAACCACCCAGAACCTGGTGG	0.537													3	69					0	0	0.009096	0	0
ZNF200	7752	broad.mit.edu	37	16	3282875	3282875	+	Silent	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr16:3282875C>T	uc002cuj.2	-	3	929	c.297G>A	c.(295-297)AAG>AAA	p.K99K	ZNF200_uc002cum.3_Silent_p.K99K|ZNF200_uc010bti.2_Silent_p.K99K|ZNF200_uc002cuk.2_Silent_p.K99K|ZNF200_uc002cui.2_Silent_p.K99K|ZNF200_uc002cul.3_Silent_p.K99K	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TCTCTTGTTCCTTTTGGACTC	0.478													12	32					0	0	0.007413	0	0
USP31	57478	broad.mit.edu	37	16	23085199	23085199	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr16:23085199A>G	uc002dll.2	-	14	2179	c.2179T>C	c.(2179-2181)TAC>CAC	p.Y727H	USP31_uc002dlk.2_5'Flank|USP31_uc010vca.1_Missense_Mutation_p.Y30H|USP31_uc010bxm.2_Missense_Mutation_p.Y15H	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	727					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		TTCTTACAGTACGCTGCCAAA	0.542													6	26					0	0	0.001984	0	0
SBK1	388228	broad.mit.edu	37	16	28331420	28331420	+	Silent	SNP	G	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr16:28331420G>C	uc002dpd.2	+	4	1242	c.453G>C	c.(451-453)GTG>GTC	p.V151V		NM_001024401	NP_001019572	Q52WX2	SBK1_HUMAN	SH3-binding kinase 1	151	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|kidney(1)	2						AGGACACGGTGAAGCGCTGTG	0.716													3	7					0	0	0.009096	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890622	32890622	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr16:32890622T>G	uc002edh.1	-	5	440	c.264A>C	c.(262-264)AAA>AAC	p.K88N	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						CGTTGGTGTTTTTGTAGACCA	0.512													5	40					0	0	0.001168	0	0
IRX6	79190	broad.mit.edu	37	16	55362679	55362679	+	Silent	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr16:55362679G>A	uc002ehy.2	+	5	1322	c.789G>A	c.(787-789)GAG>GAA	p.E263E	IRX6_uc002ehx.2_Silent_p.E263E	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	263						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						aggaagaggaggaggaggagg	0.493													3	41					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	17	3144347	3144347	+	Silent	SNP	C	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr17:3144347C>A	uc002fvf.2	+	1	431	c.378C>A	c.(376-378)ATC>ATA	p.I126I						SubName: Full=Olfactory receptor OR17-1;																		ATGTGGCCATCTGCTGCCCCC	0.577													6	53					5.9392e-07	6.37227e-07	0.001168	1	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	16					0	0	0.014758	0	0
TP53	7157	broad.mit.edu	37	17	7578458	7578458	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr17:7578458G>T	uc002gim.2	-	5	666	c.472C>A	c.(472-474)CGC>AGC	p.R158S	TP53_uc002gig.1_Missense_Mutation_p.R158S|TP53_uc002gih.2_Missense_Mutation_p.R158S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26S|TP53_uc010cng.1_Missense_Mutation_p.R26S|TP53_uc002gii.1_Missense_Mutation_p.R26S|TP53_uc010cnh.1_Missense_Mutation_p.R158S|TP53_uc010cni.1_Missense_Mutation_p.R158S|TP53_uc002gij.2_Missense_Mutation_p.R158S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65S|TP53_uc002gio.2_Missense_Mutation_p.R26S|TP53_uc010vug.1_Missense_Mutation_p.R119S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(53)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.V157_R158delVR(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.R156fs*12(1)|p.R158F(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCATGGCGCGGACGCGGGTG	0.622		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	72					1.67305e-13	1.98073e-13	0.006230	1	0
WDR16	146845	broad.mit.edu	37	17	9546373	9546373	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr17:9546373A>G	uc002gly.2	+	14	1790	c.1721A>G	c.(1720-1722)TAT>TGT	p.Y574C	USP43_uc002gma.3_5'Flank|USP43_uc010cod.2_5'Flank|USP43_uc010vva.1_5'Flank|WDR16_uc002glz.2_Missense_Mutation_p.Y506C|WDR16_uc010coc.2_Missense_Mutation_p.Y584C	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	574	WD 10.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GTTTGGGATTATAATGAGGGT	0.433													8	34					0	0	0.006214	0	0
HNF1B	6928	broad.mit.edu	37	17	36093613	36093613	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr17:36093613G>T	uc002hok.3	-	3	967	c.746C>A	c.(745-747)GCC>GAC	p.A249D	HNF1B_uc010wdi.1_Missense_Mutation_p.A223D|HNF1B_uc010cve.1_Missense_Mutation_p.A57D	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	249	Homeobox; HNF1-type.				endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			CCGATCGTAGGCCTGGTACAA	0.582									Hereditary_Prostate_Cancer				20	118					1.10923e-09	1.26945e-09	0.016522	1	0
PTPRM	5797	broad.mit.edu	37	18	8113636	8113636	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr18:8113636T>A	uc002knn.3	+	12	2512	c.2009T>A	c.(2008-2010)CTC>CAC	p.L670H	PTPRM_uc010dkv.2_Missense_Mutation_p.L670H|PTPRM_uc010wzl.1_Missense_Mutation_p.L457H	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	670	Fibronectin type-III 4.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCAGACAGCCTCCAAGCTGCG	0.418													33	128					0	0	0.006230	0	0
DSG1	1828	broad.mit.edu	37	18	28935112	28935112	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr18:28935112G>T	uc002kwp.2	+	15	3165	c.2953G>T	c.(2953-2955)GGT>TGT	p.G985C	DSG1_uc010xbp.1_Missense_Mutation_p.G344C	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	985	Cytoplasmic (Potential).|Gly/Ser-rich.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CACCAGCATGGGTGCTGGGAG	0.602													33	81					3.90053e-15	4.67156e-15	0.012213	1	0
B3GNT3	10331	broad.mit.edu	37	19	17922692	17922692	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr19:17922692C>A	uc002nhk.1	+	3	965	c.880C>A	c.(880-882)CCC>ACC	p.P294T	B3GNT3_uc002nhl.1_Missense_Mutation_p.P294T|B3GNT3_uc010ebd.1_Missense_Mutation_p.P294T|B3GNT3_uc010ebe.1_Missense_Mutation_p.P294T	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	294	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						GGACATCTTCCCCATTGATGA	0.622													15	142					2.94398e-08	3.26054e-08	0.007413	1	0
ZNF536	9745	broad.mit.edu	37	19	31040286	31040286	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr19:31040286G>T	uc002nsu.1	+	4	3898	c.3760G>T	c.(3760-3762)GGG>TGG	p.G1254W	ZNF536_uc010edd.1_Missense_Mutation_p.G1254W	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCCGGAGCGGGGGCCCCAGAG	0.607													5	17					2.0095e-06	2.1338e-06	0.001984	1	0
ATP4A	495	broad.mit.edu	37	19	36046429	36046429	+	Silent	SNP	G	C	C	rs150964145	byFrequency	TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr19:36046429G>C	uc002oal.1	-	14	2099	c.2070C>G	c.(2068-2070)GTC>GTG	p.V690V	ATP4A_uc010eee.1_5'UTR	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	690	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GCAGGGCCTCGACCAGTTCCG	0.657													4	59					0	0	0.009096	0	0
PSG11	5680	broad.mit.edu	37	19	43519344	43519344	+	Silent	SNP	A	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr19:43519344A>G	uc002ovm.1	-	4	995	c.888T>C	c.(886-888)AAT>AAC	p.N296N	PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG11_uc002ovn.1_Silent_p.N302N|PSG11_uc002ovo.1_Silent_p.N174N|PSG11_uc002ovp.1_Silent_p.N174N	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	296	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CATAGAGCCCATTATGCTTTG	0.463													36	106					0	0	0.007835	0	0
LILRA4	23547	broad.mit.edu	37	19	54849804	54849804	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr19:54849804T>A	uc002qfj.2	-	3	275	c.218A>T	c.(217-219)AAA>ATA	p.K73I	LILRA4_uc002qfi.2_Missense_Mutation_p.K7I	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	73	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CTCCAGTGTTTTTAATATGTG	0.522													44	102					0	0	0.014410	0	0
ZNF749	388567	broad.mit.edu	37	19	57956103	57956104	+	Missense_Mutation	DNP	TG	CC	CC			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr19:57956103_57956104TG>CC	uc002qoq.2	+	3	1841_1842	c.1587_1588TG>CC	c.(1585-1590)CATGAG>CACCAG	p.E530Q	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	530	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TAGTTCAGCATGAGAAAATCCA	0.45													4	67					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	2	89586689	89586689	+	RNA	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr2:89586689C>T	uc010ytr.1	-	7		c.1070G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		GTGACACTGTCTCCTTACAGA	0.473													22	54					0	0	0.008361	0	0
C2orf40	84417	broad.mit.edu	37	2	106690448	106690448	+	Silent	SNP	C	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr2:106690448C>G	uc010fjf.2	+	3	342	c.234C>G	c.(232-234)CCC>CCG	p.P78P		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	78						extracellular region|transport vesicle					0						GGACTCGGCCCGAGGTGCAGC	0.577													34	79					0	0	0.008740	0	0
SCN1A	6323	broad.mit.edu	37	2	166901577	166901577	+	Silent	SNP	T	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr2:166901577T>C	uc010zcz.1	-	10	1656	c.1638A>G	c.(1636-1638)GAA>GAG	p.E546E	SCN1A_uc002udo.3_Silent_p.E415E|SCN1A_uc010fpk.2_Silent_p.E415E	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	546						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGTACCTCTTTTCATATGTCA	0.428													26	51					0	0	0.005443	0	0
SCN7A	6332	broad.mit.edu	37	2	167288988	167288988	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr2:167288988C>T	uc002udu.1	-	15	2559	c.2432G>A	c.(2431-2433)AGC>AAC	p.S811N	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	811					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TGTGCCACTGCTTTTTTCCTT	0.388													44	112					0	0	0.014410	0	0
LRP2	4036	broad.mit.edu	37	2	170060647	170060647	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr2:170060647C>T	uc002ues.2	-	42	8063	c.7850G>A	c.(7849-7851)CGA>CAA	p.R2617Q		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2617	LDL-receptor class B 29.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTTGTTAGCTCGGTAAATTCT	0.443													101	180					0	0	0.014410	0	0
LRP2	4036	broad.mit.edu	37	2	170115593	170115593	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr2:170115593G>A	uc002ues.2	-	17	2668	c.2455C>T	c.(2455-2457)CGC>TGC	p.R819C	LRP2_uc010zdf.1_Missense_Mutation_p.R682C	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	819	LDL-receptor class B 7.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACTACTGTGCGTCTCGTTTTA	0.398													31	122					0	0	0.017118	0	0
COL3A1	1281	broad.mit.edu	37	2	189850395	189850395	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr2:189850395C>G	uc002uqj.1	+	4	455	c.338C>G	c.(337-339)CCT>CGT	p.P113R		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	113					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTTTAGGGCCCTCCTGGTATT	0.413													9	19					0	0	0.004482	0	0
MARS2	92935	broad.mit.edu	37	2	198570143	198570143	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr2:198570143C>T	uc002uuq.2	+	1	57	c.14C>T	c.(13-15)TCC>TTC	p.S5F	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	5					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	CTGCGAACGTCCGTCCTCCGC	0.682													8	47					0	0	0.003080	0	0
PLCB1	23236	broad.mit.edu	37	20	8737747	8737747	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr20:8737747G>T	uc002wnb.2	+	24	2581	c.2578G>T	c.(2578-2580)GCA>TCA	p.A860S	PLCB1_uc010zrb.1_Missense_Mutation_p.A759S|PLCB1_uc002wna.2_Missense_Mutation_p.A860S|PLCB1_uc002wnc.1_Missense_Mutation_p.A759S|PLCB1_uc002wnd.1_Missense_Mutation_p.A437S	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	860					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AACGACTCCAGCAGAAAATGG	0.478													21	82					9.57634e-11	1.10827e-10	0.018920	1	0
SSTR4	6754	broad.mit.edu	37	20	23016128	23016128	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr20:23016128C>T	uc002wsr.2	+	1	72	c.8C>T	c.(7-9)GCC>GTC	p.A3V		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	3	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GTCATGAGCGCCCCCTCGACG	0.781													5	12					0	0	0.014758	0	0
ATP9A	10079	broad.mit.edu	37	20	50224091	50224091	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr20:50224091T>C	uc002xwg.1	-	26	2778	c.2778A>G	c.(2776-2778)ATA>ATG	p.I926M	ATP9A_uc010gih.1_Missense_Mutation_p.I790M|ATP9A_uc002xwf.1_Missense_Mutation_p.I98M	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	926	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TCAAAACCCATATTAAGAATG	0.498													5	45					0	0	0.001984	0	0
GAB4	128954	broad.mit.edu	37	22	17473039	17473039	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr22:17473039G>A	uc002zlw.2	-	2	310	c.202C>T	c.(202-204)CGG>TGG	p.R68W	GAB4_uc010gqs.1_Missense_Mutation_p.R68W	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	68	PH.									large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TGGCCCCTCCGCAGGATAAAC	0.493													50	93					0	0	0.014410	0	0
LOC96610	96610	broad.mit.edu	37	22	22664156	22664156	+	RNA	SNP	C	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr22:22664156C>A	uc011aim.1	+	30		c.2013C>A			LOC96610_uc011aiq.1_RNA					Parts of antibodies, mostly variable regions.												0						GTGATTCGAACTGTCAGTGGG	0.473													6	64					3.86212e-05	4.01816e-05	0.008291	1	0
DCLK3	85443	broad.mit.edu	37	3	36779214	36779214	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr3:36779214G>C	uc003cgi.2	-	2	1428	c.937C>G	c.(937-939)CTC>GTC	p.L313V		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	313						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						TCATCTCTGAGAGTCATCCTT	0.582													59	71					0	0	0.014410	0	0
GNL3	26354	broad.mit.edu	37	3	52727062	52727062	+	Silent	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr3:52727062G>A	uc003dfd.2	+	10	1217	c.1044G>A	c.(1042-1044)CAG>CAA	p.Q348Q	GNL3_uc003dfe.2_Silent_p.Q336Q|GNL3_uc003dff.2_Silent_p.Q336Q	NM_014366	NP_055181	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3	348	Intermediate (By similarity).				regulation of cell proliferation	nucleolus	GTP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		ATGCTCGACAGGTAAAAGGAC	0.463													3	33					0	0	0.009096	0	0
PIK3CA	5290	broad.mit.edu	37	3	178917478	178917478	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr3:178917478G>A	uc003fjk.2	+	3	510	c.353G>A	c.(352-354)GGT>GAT	p.G118D		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	118					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G118D(6)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTTATTAAAGGTTTTGCTATC	0.338		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	36					0	0	0.007413	0	0
SLIT2	9353	broad.mit.edu	37	4	20597371	20597371	+	Silent	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr4:20597371C>T	uc003gpr.1	+	31	3438	c.3234C>T	c.(3232-3234)GAC>GAT	p.D1078D	SLIT2_uc003gps.1_Silent_p.D1070D	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1078	EGF-like 5; calcium-binding (Potential).				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding	p.D1078D(1)		central_nervous_system(4)|skin(4)|ovary(3)	11						TCGATTTTGACGACTGCCAAG	0.468													76	83					0	0	0.014410	0	0
DCHS2	54798	broad.mit.edu	37	4	155254316	155254316	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr4:155254316C>A	uc003inw.2	-	9	1547	c.1547G>T	c.(1546-1548)CGG>CTG	p.R516L	DCHS2_uc003inx.2_Missense_Mutation_p.R1015L	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	516	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GATGGAGTACCGGATGAGTCC	0.647													13	29					7.03913e-09	7.88076e-09	0.013537	1	0
CCDC110	256309	broad.mit.edu	37	4	186380589	186380589	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr4:186380589G>C	uc003ixu.3	-	6	1228	c.1152C>G	c.(1150-1152)TTC>TTG	p.F384L	CCDC110_uc003ixv.3_Missense_Mutation_p.F347L|CCDC110_uc011ckt.1_Missense_Mutation_p.F384L	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	384						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTTGGTCGAGGAAGGACAGTG	0.308													25	88					0	0	0.013726	0	0
EGFLAM	133584	broad.mit.edu	37	5	38464022	38464022	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr5:38464022T>G	uc003jlc.1	+	23	3312	c.2988T>G	c.(2986-2988)GAT>GAG	p.D996E	EGFLAM_uc003jlb.1_Missense_Mutation_p.D988E|EGFLAM_uc003jle.1_Missense_Mutation_p.D754E|EGFLAM_uc003jlf.1_Missense_Mutation_p.D354E|EGFLAM_uc003jlg.1_Missense_Mutation_p.D131E|EGFLAM_uc003jlh.1_Missense_Mutation_p.D78E	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	996	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TGTCCACCGATTACCACATTT	0.517													3	58					0	0	0.009096	0	0
ITGA2	3673	broad.mit.edu	37	5	52344295	52344295	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr5:52344295C>A	uc003joy.2	+	5	633	c.490C>A	c.(490-492)CCT>ACT	p.P164T	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.P88T|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	164	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CAGCTTCTCACCTGCAACTCA	0.478													41	39					1.00776e-21	1.2357e-21	0.014410	1	0
PCDHA7	56141	broad.mit.edu	37	5	140214298	140214298	+	Silent	SNP	G	T	T	rs61730625		TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr5:140214298G>T	uc003lhq.2	+	1	330	c.330G>T	c.(328-330)GTG>GTT	p.V110V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.V110V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	110	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGATCGTGGAAAGGCCGC	0.557													178	340					1.79791e-67	2.28623e-67	0.014410	1	0
NR3C1	2908	broad.mit.edu	37	5	142779650	142779650	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr5:142779650T>C	uc003lmz.2	-	2	1247	c.755A>G	c.(754-756)GAC>GGC	p.D252G	NR3C1_uc003lmy.2_Missense_Mutation_p.D252G|NR3C1_uc003lna.2_Missense_Mutation_p.D252G|NR3C1_uc003lnb.2_Missense_Mutation_p.D252G|NR3C1_uc011dbk.1_Intron|NR3C1_uc003lnc.2_Missense_Mutation_p.D252G|NR3C1_uc003lnd.2_Missense_Mutation_p.D252G|NR3C1_uc003lne.2_Missense_Mutation_p.D252G|NR3C1_uc003lnf.2_Missense_Mutation_p.D252G|NR3C1_uc003lng.2_Missense_Mutation_p.D252G|NR3C1_uc003lnh.2_Missense_Mutation_p.D252G|NR3C1_uc003lni.2_Missense_Mutation_p.D252G	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	252	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	GGGTTTAGTGTCCGGTAAAAT	0.413													6	94					0	0	0.004482	0	0
SH3RF2	153769	broad.mit.edu	37	5	145393444	145393444	+	Silent	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr5:145393444G>A	uc003lnt.2	+	5	1117	c.879G>A	c.(877-879)AGG>AGA	p.R293R	SH3RF2_uc011dbl.1_Silent_p.R293R	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	293							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTCCAGGAGGAAGGTGCCTG	0.577													14	73					0	0	0.006122	0	0
TIGD6	81789	broad.mit.edu	37	5	149375645	149375645	+	Silent	SNP	G	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr5:149375645G>T	uc003lri.2	-	2	1029	c.267C>A	c.(265-267)ATC>ATA	p.I89I	TIGD6_uc003lrj.2_Silent_p.I89I	NM_030953	NP_112215	Q17RP2	TIGD6_HUMAN	hypothetical protein LOC81789	89	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TTTTGGCATGGATTTCTTGAA	0.453													94	114					1.22118e-62	1.53392e-62	0.014410	1	0
FAT2	2196	broad.mit.edu	37	5	150943010	150943010	+	Silent	SNP	A	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr5:150943010A>G	uc003lue.3	-	2	3463	c.3450T>C	c.(3448-3450)GCT>GCC	p.A1150A	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Silent_p.A1150A	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1150	Extracellular (Potential).|Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCCCACGGGAGCATCCTCCT	0.542													9	95					0	0	0.010729	0	0
FAM83B	222584	broad.mit.edu	37	6	54806263	54806263	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr6:54806263C>A	uc003pck.2	+	5	2610	c.2494C>A	c.(2494-2496)CAT>AAT	p.H832N		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	832										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TAGAAGAAAGCATTCTTCCTC	0.378													15	28					6.31663e-08	6.92141e-08	0.003163	1	0
C6orf174	387104	broad.mit.edu	37	6	127797356	127797356	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr6:127797356G>C	uc003qbd.2	-	6	2680	c.1815C>G	c.(1813-1815)ATC>ATG	p.I605M	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	605	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CCAGTTCGACGATTTTCCTGC	0.607													15	162					0	0	0.004007	0	0
POM121L12	285877	broad.mit.edu	37	7	53103578	53103578	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr7:53103578G>T	uc003tpz.2	+	1	230	c.214G>T	c.(214-216)GTG>TTG	p.V72L		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	72											0						GGGGCGCCCGGTGCCCAGCAC	0.711													12	49					3.87621e-19	4.69705e-19	0.020292	1	0
SPDYE5	442590	broad.mit.edu	37	7	75130895	75130895	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr7:75130895C>T	uc011kfy.1	+	6	906	c.770C>T	c.(769-771)CCG>CTG	p.P257L		NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	speedy homolog E5	257	Arg-rich.										0						TCCATGAACCCGAGGGCCAGG	0.592													6	284					0	0	0.004482	0	0
CALCR	799	broad.mit.edu	37	7	93065307	93065307	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr7:93065307C>T	uc003umv.1	-	13	1469	c.1208G>A	c.(1207-1209)GGG>GAG	p.G403E	CALCR_uc011kia.1_Missense_Mutation_p.G183E|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.G369E|CALCR_uc003umw.2_Missense_Mutation_p.G369E	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	385	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	ATATATCTTCCCAAGCATCTT	0.453													8	46					0	0	0.010729	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97922907	97922907	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr7:97922907C>T	uc003upj.2	-	14	1725	c.1462G>A	c.(1462-1464)GGA>AGA	p.G488R		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	488	Binds F-actin.			Missing: Loss ability to induce the formation of actin clusters; induce the formation of long filopodia.	filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			GGGTTTTCTCCGCTGCAGGGG	0.527													18	90					0	0	0.019004	0	0
FLNC	2318	broad.mit.edu	37	7	128494111	128494111	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr7:128494111C>T	uc003vnz.3	+	40	6777	c.6568C>T	c.(6568-6570)CGC>TGC	p.R2190C	FLNC_uc003voa.3_Missense_Mutation_p.R2157C	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2190	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CCGCACGGAGCGCACGGAGAT	0.657													18	32					0	0	0.012319	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617899	77617899	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr8:77617899T>G	uc003yav.2	+	2	1963	c.1576T>G	c.(1576-1578)TCG>GCG	p.S526A	ZFHX4_uc003yat.1_Missense_Mutation_p.S526A|ZFHX4_uc003yau.1_Missense_Mutation_p.S526A|ZFHX4_uc003yaw.1_Missense_Mutation_p.S526A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	526	Poly-Ser.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTCGTCCTCCTCGGCGACTGT	0.428										HNSCC(33;0.089)			10	17					0	0	0.008291	0	0
MATN2	4147	broad.mit.edu	37	8	99019780	99019780	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr8:99019780T>G	uc003yic.2	+	10	1755	c.1524T>G	c.(1522-1524)TGT>TGG	p.C508W	MATN2_uc010mbh.1_Missense_Mutation_p.C467W|MATN2_uc003yid.2_Missense_Mutation_p.C508W|MATN2_uc003yie.1_Missense_Mutation_p.C508W|MATN2_uc010mbi.1_Missense_Mutation_p.C341W|MATN2_uc010mbj.1_Missense_Mutation_p.C7W	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	508	EGF-like 7.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			CCTTTGCCTGTCAGTGTCCTG	0.557													34	63					0	0	0.021022	0	0
COL22A1	169044	broad.mit.edu	37	8	139793188	139793188	+	Silent	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr8:139793188G>A	uc003yvd.2	-	13	2079	c.1632C>T	c.(1630-1632)GAC>GAT	p.D544D		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	544	Pro-rich.|Gly-rich.|Collagen-like 2.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTTGCTGCCGTCTCTCCCAG	0.527										HNSCC(7;0.00092)			20	36					0	0	0.006320	0	0
FAM75C1	441452	broad.mit.edu	37	9	90534221	90534221	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr9:90534221A>T	uc010mqi.2	+	2	270	c.241A>T	c.(241-243)AGG>TGG	p.R81W	FAM75C1_uc004apq.3_Missense_Mutation_p.R64W	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						AACAGGGCGGAGGGGGAGGCC	0.572													35	111					0	0	0.013114	0	0
GRIN3A	116443	broad.mit.edu	37	9	104341582	104341582	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr9:104341582C>G	uc004bbp.1	-	7	3428	c.2827G>C	c.(2827-2829)GGT>CGT	p.G943R	GRIN3A_uc004bbo.1_Missense_Mutation_p.G18R|GRIN3A_uc004bbq.1_Missense_Mutation_p.G943R	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	943	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ATGGACAGACCAAATCCAATG	0.448													4	62					0	0	0.009096	0	0
TLR8	51311	broad.mit.edu	37	X	12938644	12938644	+	Silent	SNP	C	T	T			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chrX:12938644C>T	uc004cve.2	+	2	1553	c.1485C>T	c.(1483-1485)TTC>TTT	p.F495F	TLR8_uc004cvd.2_Silent_p.F513F	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	495	LRR 13.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						GTATTTTCTTCATTGGGCCAA	0.378													9	88					0	0	0.010729	0	0
CXorf23	256643	broad.mit.edu	37	X	19955647	19955647	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chrX:19955647A>C	uc004czp.2	-	8	1749	c.1749T>G	c.(1747-1749)GAT>GAG	p.D583E	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Missense_Mutation_p.D148E|CXorf23_uc004czo.2_Missense_Mutation_p.D533E	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	583						mitochondrion				lung(1)|skin(1)	2						AATTCTGATCATCCCTAATAA	0.259													14	50					0	0	0.004007	0	0
FAM47C	442444	broad.mit.edu	37	X	37027101	37027101	+	Silent	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chrX:37027101G>A	uc004ddl.1	+	1	632	c.618G>A	c.(616-618)CCG>CCA	p.P206P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	206										ovary(3)	3						CCAAGACTCCGGTGTCCAGTC	0.652													23	63					0	0	0.005443	0	0
MIRLET7F2	406889	broad.mit.edu	37	X	53584202	53584202	+	RNA	SNP	C	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chrX:53584202C>A	hsa-let-7f-2|MI0000068	-			c.34C>A			HUWE1_uc004dsn.2_Intron|HUWE1_uc004dsp.2_Intron|MIR98_hsa-mir-98|MI0000100_5'Flank|uc004dsr.1_5'Flank|uc004dss.2_RNA																	0						GGGGTATGACCCTAAAACTAT	0.463													18	97					3.32936e-07	3.60973e-07	0.006122	1	0
DGAT2L6	347516	broad.mit.edu	37	X	69421805	69421805	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chrX:69421805G>A	uc004dxx.1	+	5	635	c.538G>A	c.(538-540)GTG>ATG	p.V180M		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	180					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						AGGCAATGCCGTGGTTATTGT	0.512													14	79					0	0	0.004990	0	0
Unknown	0	broad.mit.edu	37	X	114953505	114953505	+	RNA	SNP	G	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chrX:114953505G>A	uc004eqf.2	-	1		c.160C>T								full-length cDNA clone CS0DJ015YA07 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).																		TAATATGATCGTTGTTCTCAG	0.478													6	34					0	0	0.006214	0	0
HS6ST2	90161	broad.mit.edu	37	X	131762858	131762858	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chrX:131762858T>A	uc011mve.1	-	4	1627	c.1211A>T	c.(1210-1212)AAC>ATC	p.N404I	HS6ST2_uc011mvb.1_Missense_Mutation_p.N298I|HS6ST2_uc011mvc.1_Missense_Mutation_p.N258I|HS6ST2_uc011mvd.1_Missense_Mutation_p.N444I|HS6ST2_uc011mva.1_Missense_Mutation_p.N130I	NM_147175	NP_671704	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2 isoform	404	Lumenal (Potential).					integral to membrane	sulfotransferase activity				0	Acute lymphoblastic leukemia(192;0.000127)					GACAGAGAGGTTGTAGCAGCC	0.522													29	122					0	0	0.019004	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370731	35370731	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:35370731delC	uc001byc.2	-	1	254	c.254delG	c.(253-255)GGTfs	p.G85fs		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	85					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				GGTGCTGCTACCCCCCCCAAC	0.701													4	7	---	---	---	---					
SLC39A1	27173	broad.mit.edu	37	1	153934816	153934826	+	Frame_Shift_Del	DEL	CTGGCGGGAAG	-	-	rs11554761	byFrequency	TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr1:153934816_153934826delCTGGCGGGAAG	uc001fdh.2	-	3	357_367	c.188_198delCTTCCCGCCAG	c.(187-198)GCTTCCCGCCAGfs	p.A63fs	SLC39A1_uc001fdi.2_Frame_Shift_Del_p.A63fs|SLC39A1_uc001fdj.2_Frame_Shift_Del_p.A63fs|SLC39A1_uc001fdk.2_Frame_Shift_Del_p.A63fs|SLC39A1_uc010pee.1_Intron|SLC39A1_uc001fdl.2_Frame_Shift_Del_p.A63fs	NM_014437	NP_055252	Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter),	63_66	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		TCAGGGCTTTCTGGCGGGAAGCTGGGTAGGG	0.597													15	121	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	G	G	rs2981599		TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr16:3119304_3119305insG	uc002cto.2	+	6	864_865	c.653_654insG	c.(652-654)GACfs	p.D218fs	IL32_uc002ctk.2_Frame_Shift_Ins_p.D115fs|IL32_uc010uwp.1_Frame_Shift_Ins_p.D152fs|IL32_uc010btb.2_Frame_Shift_Ins_p.D162fs|IL32_uc002ctl.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctm.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctn.2_Frame_Shift_Ins_p.D172fs|IL32_uc002cts.3_Frame_Shift_Ins_p.D172fs|IL32_uc002ctp.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctq.2_Frame_Shift_Ins_p.D218fs|IL32_uc002ctr.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctt.2_Frame_Shift_Ins_p.D172fs|IL32_uc010uwr.1_Frame_Shift_Ins_p.D132fs|IL32_uc002ctu.2_Frame_Shift_Ins_p.D163fs	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CCACGGGGGGACAAGGAGGAGC	0.574													13	288	---	---	---	---					
PAFAH1B1	5048	broad.mit.edu	37	17	2569347	2569347	+	Frame_Shift_Del	DEL	A	-	-			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr17:2569347delA	uc002fuw.3	+	4	723	c.155delA	c.(154-156)GAAfs	p.E52fs	PAFAH1B1_uc010ckb.1_Intron	NM_000430	NP_000421	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase,	52	Interaction with NDEL1 (By similarity).|Interaction with NDE1 (By similarity).				acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			skin(1)	1						GGTCTTTTGGAAAAAAAATGG	0.244													2	4	---	---	---	---					
C9orf79	286234	broad.mit.edu	37	9	90500087	90500087	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DU-8165-01A-11D-2253-08	TCGA-DU-8165-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	3470090e-ffbe-4874-ae9f-9b8b85494ed9	ac772409-6c5c-4b63-af6b-c77a4af6c6eb	g.chr9:90500087delC	uc004app.3	+	4	720	c.685delC	c.(685-687)CTTfs	p.L229fs	C9orf79_uc004apo.1_Frame_Shift_Del_p.L41fs	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	229	Pro-rich.					integral to membrane				ovary(3)	3						AGAGCCCTTGCTTCCCCTAAA	0.617													54	233	---	---	---	---					
