Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LOC440563	440563	broad.mit.edu	37	1	13183440	13183440	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr1:13183440G>A	uc010obg.1	-	1	528	c.433C>T	c.(433-435)CGC>TGC	p.R145C		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	145						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						ATGCGCTGGTGTTTCGAGGGC	0.502000													9	356					0	0	0.069234	0	0
HSPG2	3339	broad.mit.edu	37	1	22162039	22162039	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr1:22162039T>C	uc001bfj.2	-	76	10487	c.10447A>G	c.(10447-10449)ATC>GTC	p.I3483V	HSPG2_uc009vqd.2_Missense_Mutation_p.I3484V	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3483	Ig-like C2-type 20.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTACCTTGGATAACCAGCTGG	0.562000													9	29					0	0	0.080935	0	0
SEPN1	57190	broad.mit.edu	37	1	26135530	26135530	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr1:26135530G>A	uc010oer.1	+	8	816	c.761G>A	c.(760-762)CGG>CAG	p.R254Q	SEPN1_uc010oes.1_Missense_Mutation_p.R220Q	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	254						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		ATCATCCACCGGCTCCTGAGC	0.667000													16	106					0	0	0.033300	0	0
PALMD	54873	broad.mit.edu	37	1	100133315	100133315	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr1:100133315A>G	uc001dsg.2	+	3	687	c.244A>G	c.(244-246)ATC>GTC	p.I82V	PALMD_uc001dsf.2_Missense_Mutation_p.I82V	NM_017734	NP_060204	Q9NP74	PALMD_HUMAN	palmdelphin	82	Potential.				regulation of cell shape	cytoplasm|membrane				ovary(2)|pancreas(1)	3		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		AGAACAAAGTATCCTCAGGTA	0.433000													12	139					0	0	0.024245	0	0
ADAM30	11085	broad.mit.edu	37	1	120438457	120438457	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr1:120438457C>G	uc001eij.2	-	1	657	c.503G>C	c.(502-504)GGG>GCG	p.G168A		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	168					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AACCTGATTCCCAAACTGCTC	0.438000													36	49					0	0	0.111260	0	0
FLG2	388698	broad.mit.edu	37	1	152328035	152328035	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr1:152328035A>C	uc001ezw.3	-	3	2300	c.2227T>G	c.(2227-2229)TCT>GCT	p.S743A	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	743	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAAAGCCAGAGGACTGACCT	0.507000													8	499					0	0	0.038147	0	0
NPR1	4881	broad.mit.edu	37	1	153659546	153659546	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr1:153659546A>G	uc001fcs.3	+	12	2339	c.1918A>G	c.(1918-1920)ACC>GCC	p.T640A	NPR1_uc010pdz.1_Missense_Mutation_p.T386A|NPR1_uc010pea.1_Missense_Mutation_p.T118A	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	640	Cytoplasmic (Potential).|Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GTACTCACTCACCAATGACAT	0.562000													5	106					0	0	0.021553	0	0
KMO	8564	broad.mit.edu	37	1	241749983	241749983	+	Silent	SNP	C	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr1:241749983C>G	uc009xgp.2	+	11	1025	c.960C>G	c.(958-960)GGC>GGG	p.G320G	KMO_uc001hyy.2_Silent_p.G320G|KMO_uc009xgo.1_Silent_p.G320G	NM_003679	NP_003670	O15229	KMO_HUMAN	kynurenine 3-monooxygenase	320					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			ovary(2)	2	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			tgtttCAGGGCTTTGAAGACT	0.264000													3	87					0	0	0.004672	0	0
OR2G3	81469	broad.mit.edu	37	1	247769424	247769424	+	Silent	SNP	C	T	T	rs144392521		TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr1:247769424C>T	uc010pyz.1	+	1	537	c.537C>T	c.(535-537)TGC>TGT	p.C179C		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATTTTATTTGCGAAGTACCAG	0.453000													15	75					0	0	0.055883	0	0
PTER	9317	broad.mit.edu	37	10	16528411	16528411	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr10:16528411G>A	uc001iog.1	+	4	700	c.493G>A	c.(493-495)GGC>AGC	p.G165S	PTER_uc001ioh.1_Missense_Mutation_p.G165S|PTER_uc001ioi.1_Missense_Mutation_p.G165S|PTER_uc009xjp.1_Missense_Mutation_p.G165S	NM_030664	NP_109589	Q96BW5	PTER_HUMAN	phosphotriesterase related	165					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			ovary(2)	2						TATCAAGTGTGGCATTATTGG	0.448000													19	108					0	0	0.043863	0	0
SVIL	6840	broad.mit.edu	37	10	29811448	29811448	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr10:29811448C>G	uc001iut.1	-	16	4033	c.3280G>C	c.(3280-3282)GAG>CAG	p.E1094Q	SVIL_uc010qdw.1_5'UTR|SVIL_uc001iuu.1_Missense_Mutation_p.E668Q	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1094					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CAGAGCTTCTCCTGTGGCTGT	0.557000													9	72					0	0	0.069234	0	0
DUPD1	338599	broad.mit.edu	37	10	76803652	76803652	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr10:76803652G>A	uc001jwq.1	-	2	324	c.324C>T	c.(322-324)TAC>TAT	p.Y108Y		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	108	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CCACGCCGTGGTACTGGATGT	0.647000													17	106					0	0	0.076483	0	0
TTC12	54970	broad.mit.edu	37	11	113233185	113233185	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr11:113233185G>A	uc001pnu.2	+	19	1782	c.1677G>A	c.(1675-1677)TTG>TTA	p.L559L	TTC12_uc001pnv.2_Silent_p.L565L|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Silent_p.L409L	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	559							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		AGGAGGCCTTGCGAGCAGGAG	0.423000													14	87					0	0	0.033300	0	0
ACACB	32	broad.mit.edu	37	12	109644646	109644646	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr12:109644646C>T	uc001tob.2	+	20	3164	c.3045C>T	c.(3043-3045)CCC>CCT	p.P1015P	ACACB_uc001toc.2_Silent_p.P1015P	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1015					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TGCCAGAGCCCGTTTTTAGCA	0.527000													11	51					0	0	0.093190	0	0
SBNO1	55206	broad.mit.edu	37	12	123834923	123834923	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr12:123834923G>A	uc010tap.1	-	1	66	c.66C>T	c.(64-66)GAC>GAT	p.D22D	SBNO1_uc010tao.1_Silent_p.D22D|SBNO1_uc010taq.1_5'UTR|SBNO1_uc001uet.2_Silent_p.D22D|SBNO1_uc001ueu.2_Silent_p.D22D|SBNO1_uc001uev.2_Silent_p.D22D|SBNO1_uc009zxy.1_Silent_p.D22D	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	22							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TATCAAAGAGGTCATTCGGAC	0.418000													11	378					0	0	0.105934	0	0
P2RX2	22953	broad.mit.edu	37	12	133196268	133196268	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr12:133196268G>A	uc001ukj.1	+	3	313	c.313G>A	c.(313-315)GGC>AGC	p.G105S	P2RX2_uc001uki.1_Missense_Mutation_p.G105S|P2RX2_uc001ukk.1_Missense_Mutation_p.G105S|P2RX2_uc001ukl.1_Intron|P2RX2_uc001ukm.1_Intron|P2RX2_uc001ukn.1_Intron|P2RX2_uc009zyt.1_Missense_Mutation_p.G105S|P2RX2_uc001uko.1_Intron	NM_170682	NP_733782	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X2 isoform A	105	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		AGCCCAGGGGGGCAGCGTGTT	0.637000													6	23					0	0	0.029380	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33017399	33017399	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr13:33017399C>T	uc010abe.1	-	7	1297	c.1275G>A	c.(1273-1275)TCG>TCA	p.S425S	N4BP2L2_uc001uug.2_Silent_p.S308S|N4BP2L2_uc010abd.1_Silent_p.S338S|N4BP2L2_uc001uuh.2_Silent_p.S256S|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Silent_p.S410S	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		ATGCTGCCACCGAAGTGAAGA	0.408000													24	86					0	0	0.054565	0	0
TPP2	7174	broad.mit.edu	37	13	103287941	103287941	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr13:103287941G>A	uc001vpi.3	+	12	1501	c.1398G>A	c.(1396-1398)CTG>CTA	p.L466L		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	466					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTTTAGGTCTGAAAGCTAATA	0.408000													4	54					0	0	0.009096	0	0
TPP2	7174	broad.mit.edu	37	13	103287990	103287990	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr13:103287990G>C	uc001vpi.3	+	12	1550	c.1447G>C	c.(1447-1449)GAA>CAA	p.E483Q		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	483					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAGAGCTCTAGAAAACACTGC	0.353000													9	88					0	0	0.069234	0	0
TTC5	91875	broad.mit.edu	37	14	20763631	20763631	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr14:20763631G>A	uc001vwt.2	-	8	955	c.898C>T	c.(898-900)CAT>TAT	p.H300Y	TTC5_uc001vwu.2_Missense_Mutation_p.H157Y	NM_138376	NP_612385	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	300					DNA repair	cytoplasm|nucleus	binding			ovary(1)	1	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		GGGCCTAGATGGGCTGGGCGC	0.547000													3	61					0	0	0.004672	0	0
DAD1	1603	broad.mit.edu	37	14	23058038	23058038	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr14:23058038A>C	uc001wgl.2	-	1	106	c.26T>G	c.(25-27)ATT>AGT	p.I9S		NM_001344	NP_001335	P61803	DAD1_HUMAN	defender against cell death 1	9					anti-apoptosis|apoptosis|post-translational protein modification	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity			ovary(1)	1	all_cancers(95;5.49e-05)			GBM - Glioblastoma multiforme(265;0.0156)		GAACCGCGAAATGACAGACAC	0.572000													30	65					0	0	0.045705	0	0
MYH7	4625	broad.mit.edu	37	14	23887505	23887505	+	Silent	SNP	A	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr14:23887505A>C	uc001wjx.2	-	30	4189	c.4083T>G	c.(4081-4083)CTT>CTG	p.L1361L	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1361	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGGCCTTGGAAAGGACGCGCT	0.652000													3	104					0	0	0.004672	0	0
PRKCH	5583	broad.mit.edu	37	14	62014584	62014584	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr14:62014584C>T	uc001xfn.2	+	13	2190	c.1885C>T	c.(1885-1887)CCG>TCG	p.P629S	PRKCH_uc010tsa.1_Missense_Mutation_p.P468S|PRKCH_uc010tsb.1_Missense_Mutation_p.P197S|PRKCH_uc001xfo.2_RNA	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	629	AGC-kinase C-terminal.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		CCAAATAGAACCGCCTTTCAG	0.522000													50	130					0	0	0.048971	0	0
ASB2	51676	broad.mit.edu	37	14	94404157	94404157	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr14:94404157G>A	uc001ycc.1	-	7	2003	c.1514C>T	c.(1513-1515)GCG>GTG	p.A505V	ASB2_uc001ycb.1_Missense_Mutation_p.A199V|ASB2_uc001ycd.2_Missense_Mutation_p.A553V|ASB2_uc001yce.1_Missense_Mutation_p.A451V	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	505					intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		GATGGGCCCCGCCCAGCGGCT	0.597000													6	23					0	0	0.021553	0	0
FBN1	2200	broad.mit.edu	37	15	48760623	48760623	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr15:48760623C>T	uc001zwx.1	-	37	4896	c.4568G>A	c.(4567-4569)CGA>CAA	p.R1523Q	FBN1_uc010beo.1_5'Flank	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1523	EGF-like 26; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACAGCCAACTCGAGTTGGGTT	0.438000													4	87					0	0	0.014758	0	0
NOX5	79400	broad.mit.edu	37	15	69348973	69348973	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr15:69348973G>A	uc002ars.1	+	16	2255	c.2235G>A	c.(2233-2235)CTG>CTA	p.L745L	NOX5_uc002arp.1_Silent_p.L727L|NOX5_uc002arq.1_Silent_p.L699L|NOX5_uc010bid.1_Silent_p.L710L|NOX5_uc002arr.1_Silent_p.L717L|NOX5_uc010bie.1_Silent_p.L545L|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	745	Extracellular (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						CCCCAGCTCTGGCCAAGGTGC	0.537000													5	69					0	0	0.021553	0	0
CMTM1	113540	broad.mit.edu	37	16	66612848	66612848	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr16:66612848C>T	uc002epi.3	+	4	577	c.454C>T	c.(454-456)CCC>TCC	p.P152S	CMTM1_uc002epb.3_RNA|CMTM1_uc002epc.3_RNA|CMTM1_uc002epd.3_RNA|CMTM1_uc002epe.3_RNA|CMTM1_uc002epf.3_RNA|CMTM1_uc002epg.3_RNA|CMTM1_uc002eph.3_3'UTR|CMTM1_uc002epl.3_Missense_Mutation_p.P105S|CMTM1_uc002epj.3_3'UTR|CMTM1_uc002epk.3_Missense_Mutation_p.P99S|CMTM1_uc002epa.3_3'UTR|CMTM1_uc002epn.3_3'UTR|CMTM1_uc002epo.3_RNA|CMTM1_uc002epp.3_RNA|CMTM1_uc002epq.3_RNA|CMTM1_uc010cds.2_RNA|CMTM1_uc002epr.3_Missense_Mutation_p.P269S|CMTM1_uc002epm.3_RNA|CMTM1_uc002eps.2_RNA|CMTM2_uc002ept.2_5'Flank|CMTM2_uc010cdu.2_5'Flank	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1	152					chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		GAAGCTTTCCCCCGCCAAGGA	0.602000													15	59					0	0	0.038395	0	0
TP53	7157	broad.mit.edu	37	17	7578413	7578413	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr17:7578413C>G	uc002gim.2	-	5	711	c.517G>C	c.(517-519)GTG>CTG	p.V173L	TP53_uc002gig.1_Missense_Mutation_p.V173L|TP53_uc002gih.2_Missense_Mutation_p.V173L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41L|TP53_uc010cng.1_Missense_Mutation_p.V41L|TP53_uc002gii.1_Missense_Mutation_p.V41L|TP53_uc010cnh.1_Missense_Mutation_p.V173L|TP53_uc010cni.1_Missense_Mutation_p.V173L|TP53_uc002gij.2_Missense_Mutation_p.V173L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80L|TP53_uc002gio.2_Missense_Mutation_p.V41L|TP53_uc010vug.1_Missense_Mutation_p.V134L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(54)|p.V173M(40)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V80L(2)|p.V173fs*59(2)|p.V41L(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.V80M(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.V41M(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			42	44					0	0	0.048971	0	0
ALOX12B	242	broad.mit.edu	37	17	7976156	7976156	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr17:7976156T>C	uc002gjy.1	-	15	2300	c.2039A>G	c.(2038-2040)AAC>AGC	p.N680S		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	680	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						AAGGCACTTGTTGCGCTGGCG	0.587000										Multiple Myeloma(8;0.094)			6	98					0	0	0.058154	0	0
ALOX12B	242	broad.mit.edu	37	17	7976179	7976179	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr17:7976179G>A	uc002gjy.1	-	15	2277	c.2016C>T	c.(2014-2016)ATC>ATT	p.I672I		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	672	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						TGTCGTGTGAGATCTGGTTCA	0.607000										Multiple Myeloma(8;0.094)			5	75					0	0	0.038147	0	0
LLGL1	3996	broad.mit.edu	37	17	18145015	18145015	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr17:18145015C>T	uc002gsp.2	+	18	2814	c.2753C>T	c.(2752-2754)ACG>ATG	p.T918M		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	918	WD 14.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					TGCGTCTTTACGCGCCATGGC	0.652000													4	110					0	0	0.009096	0	0
HSD17B1	3292	broad.mit.edu	37	17	40705302	40705302	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr17:40705302C>T	uc002hzw.2	+	2	1226	c.258C>T	c.(256-258)GAC>GAT	p.D86D	HSD17B1_uc002hzx.2_Silent_p.D86D|HSD17B1_uc010wgm.1_RNA|uc002hzy.2_Silent_p.T93T|HSD17B1_uc010cyi.2_Silent_p.D117D	NM_000413	NP_000404	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	86					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity				0		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	GCCGCGTGGACGTGCTGGGTG	0.642000													4	40					0	0	0.014758	0	0
ANKRD40	91369	broad.mit.edu	37	17	48773483	48773483	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr17:48773483G>C	uc002iso.2	-	5	1237	c.982C>G	c.(982-984)CAA>GAA	p.Q328E		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	328											0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			TGGAAATCTTGGAGTCGAGCA	0.393000													17	68					0	0	0.062417	0	0
ARMC6	93436	broad.mit.edu	37	19	19162910	19162910	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr19:19162910C>T	uc002nld.2	+	5	1107	c.759C>T	c.(757-759)GAC>GAT	p.D253D	ARMC6_uc002nlc.2_Silent_p.D228D|ARMC6_uc010xql.1_Silent_p.D160D|ARMC6_uc002nle.2_Silent_p.D228D|ARMC6_uc010xqm.1_Silent_p.D253D	NM_033415	NP_219483	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	253	ARM 1.						protein binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			CCTTCGATGACGACATCCGTG	0.572000													12	36					0	0	0.020292	0	0
CEACAM5	1048	broad.mit.edu	37	19	42213763	42213763	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr19:42213763C>T	uc002ork.2	+	2	350	c.229C>T	c.(229-231)CGT>TGT	p.R77C	CEACAM5_uc010ehz.1_Missense_Mutation_p.R77C|CEACAM5_uc002orj.1_Missense_Mutation_p.R77C|CEACAM5_uc002orl.2_Missense_Mutation_p.R77C	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	77	Ig-like 1.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		GGATGGCAACCGTCAAATTAT	0.488000													49	128					0	0	0.048971	0	0
APOB	338	broad.mit.edu	37	2	21250764	21250764	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr2:21250764G>A	uc002red.2	-	14	2131	c.2003C>T	c.(2002-2004)CCT>CTT	p.P668L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	668	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCTTTCTTTAGGAAGGTAGTT	0.418000													17	62					0	0	0.038395	0	0
C2orf71	388939	broad.mit.edu	37	2	29287763	29287763	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr2:29287763G>A	uc002rmt.1	-	2	3839	c.3839C>T	c.(3838-3840)GCG>GTG	p.A1280V		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	1280					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						CTGGGGCTGCGCCTCTGGCTG	0.657000													14	30					0	0	0.020292	0	0
PLA2R1	22925	broad.mit.edu	37	2	160832717	160832717	+	Silent	SNP	A	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr2:160832717A>G	uc002ube.1	-	17	2664	c.2457T>C	c.(2455-2457)TAT>TAC	p.Y819Y	PLA2R1_uc010zcp.1_Silent_p.Y819Y|PLA2R1_uc002ubf.2_Silent_p.Y819Y	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	819	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CTGCATCCTGATAAAAGAGCC	0.383000													11	24					0	0	0.093190	0	0
ITGA4	3676	broad.mit.edu	37	2	182339701	182339701	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr2:182339701G>C	uc002unu.2	+	3	1097	c.334G>C	c.(334-336)GAA>CAA	p.E112Q	ITGA4_uc010zfl.1_Missense_Mutation_p.E112Q	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	112	FG-GAP 2.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CCCTAATGGAGAACCTTGTGG	0.403000													3	59					0	0	0.009096	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								37	68					0	0	0.048971	0	0
BANF2	140836	broad.mit.edu	37	20	17716423	17716423	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr20:17716423C>T	uc002wpz.2	+	4	514	c.240C>T	c.(238-240)CAC>CAT	p.H80H	BANF2_uc010zrs.1_Silent_p.H87H|BANF2_uc002wqa.2_Silent_p.H80H	NM_178477	NP_848572	Q9H503	BAFL_HUMAN	barrier to autointegration factor 2 isoform 1	80						cytoplasm|nucleus	DNA binding			skin(1)	1						AGACTTCTCACTGCCTCAAGG	0.542000													16	89					0	0	0.062417	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47592595	47592595	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr20:47592595G>A	uc002xtx.3	+	14	1969	c.1817G>A	c.(1816-1818)GGC>GAC	p.G606D		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	606					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			GATGGGAAAGGCCTTGACATG	0.532000													6	39					0	0	0.038147	0	0
FAM65C	140876	broad.mit.edu	37	20	49225174	49225174	+	Silent	SNP	C	T	T	rs144349290		TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr20:49225174C>T	uc002xvm.2	-	10	1092	c.774G>A	c.(772-774)ACG>ACA	p.T258T	FAM65C_uc010zyt.1_Silent_p.T262T|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Silent_p.T258T	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	258										ovary(2)	2						TCTCATGCAGCGTGGGGATGA	0.657000													10	156					0	0	0.093190	0	0
Unknown	0	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr22:18844763T>C	uc002zoe.2	+	4		c.2017T>C			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		TCACAGCCTCTGAGGGCAGCA	0.562000													3	7					0	0	0.004672	0	0
EIF3D	8664	broad.mit.edu	37	22	36907606	36907606	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr22:36907606G>A	uc003apq.2	-	14	1693	c.1577C>T	c.(1576-1578)ACC>ATC	p.T526I	EIF3D_uc011amr.1_Missense_Mutation_p.T353I|EIF3D_uc003apr.2_Missense_Mutation_p.T526I|EIF3D_uc011ams.1_Missense_Mutation_p.T429I|EIF3D_uc011amt.1_Missense_Mutation_p.T477I	NM_003753	NP_003744	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3	526						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			pancreas(1)	1						AGAGCTGAAGGTGCCATCAGG	0.423000											OREG0026522	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	19					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	4	69343128	69343128	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr4:69343128C>A	uc003hdz.3	+	8	813	c.749C>A	c.(748-750)ACA>AAA	p.T250K		NM_014058	NP_054777			transmembrane protease, serine 11E																		TTTGGAGTAACAATAAAACCT	0.368000													33	202					3.90053e-15	4.17914e-15	0.050027	1	0
IGJ	3512	broad.mit.edu	37	4	71522083	71522083	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr4:71522083T>C	uc003hfn.3	-	4	584	c.443A>G	c.(442-444)GAA>GGA	p.E148G	IGJ_uc010ihz.2_Missense_Mutation_p.E164G	NM_144646	NP_653247	P01591	IGJ_HUMAN	immunoglobulin J chain	148					immune response	extracellular region	antigen binding				0			Lung(101;0.235)			TAAGGCTGTTTCCACCATTTT	0.448000													12	70					0	0	0.024245	0	0
MFSD8	256471	broad.mit.edu	37	4	128851943	128851943	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr4:128851943T>C	uc003ifp.2	-	10	1056	c.893A>G	c.(892-894)TAT>TGT	p.Y298C	MFSD8_uc011cgu.1_Missense_Mutation_p.Y253C|MFSD8_uc011cgv.1_Missense_Mutation_p.Y260C|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_3'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	298	Extracellular (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						AGTCCAGGCATACATATCCAT	0.313000													8	151					0	0	0.047766	0	0
NEK1	4750	broad.mit.edu	37	4	170428878	170428878	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr4:170428878G>A	uc003isb.1	-	20	2307	c.1815C>T	c.(1813-1815)ATC>ATT	p.I605I	NEK1_uc003isc.1_Silent_p.I561I|NEK1_uc003isd.1_Silent_p.I633I|NEK1_uc003ise.1_Silent_p.I589I|NEK1_uc003isf.1_Silent_p.I536I	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	605					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		TCAGTGATTCGATTTTTTTGC	0.338000													7	45					0	0	0.047766	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239326	5239326	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr5:5239326C>T	uc003jdl.2	+	15	2355	c.2217C>T	c.(2215-2217)AAC>AAT	p.N739N	ADAMTS16_uc003jdk.1_Silent_p.N739N|ADAMTS16_uc010itk.1_RNA	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	739	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						GGGTGTGTAACGGGAATAACT	0.512000													5	206					0	0	0.014758	0	0
NUP155	9631	broad.mit.edu	37	5	37351324	37351324	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr5:37351324T>C	uc003jku.1	-	6	809	c.691A>G	c.(691-693)AAG>GAG	p.K231E	NUP155_uc003jkt.1_Missense_Mutation_p.K172E|NUP155_uc010iuz.1_Missense_Mutation_p.K231E	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	231					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAGCCATCCTTTCCAGCCAAG	0.353000													11	71					0	0	0.024245	0	0
RASGRF2	5924	broad.mit.edu	37	5	80366346	80366346	+	Silent	SNP	A	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr5:80366346A>G	uc003kha.1	+	4	579	c.579A>G	c.(577-579)CGA>CGG	p.R193R	RASGRF2_uc011ctn.1_RNA|RASGRF2_uc003khb.1_Silent_p.R21R	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	193	Potential.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AACGAATGCGACCTTACCAAA	0.423000													29	65					0	0	0.059317	0	0
FBXL17	64839	broad.mit.edu	37	5	107197443	107197443	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr5:107197443T>C	uc011cvc.1	-	9	2491	c.2084A>G	c.(2083-2085)AAC>AGC	p.N695S		NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	695											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		GGCAGACATGTTGGGGGTCCA	0.582000													5	77					0	0	0.021553	0	0
IL12B	3593	broad.mit.edu	37	5	158753714	158753714	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr5:158753714A>G	uc003lxr.1	-	2	119	c.77T>C	c.(76-78)CTG>CCG	p.L26P		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	26	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCTTTCTTCAGTTCCCATAT	0.448000													8	60					0	0	0.058154	0	0
SCGN	10590	broad.mit.edu	37	6	25670302	25670302	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr6:25670302A>G	uc003nfb.2	+	6	672	c.469A>G	c.(469-471)ATG>GTG	p.M157V	SCGN_uc010jpz.2_Silent_p.P66P	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	157	EF-hand 4.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						CACTGGCACCATGGTAAGTAA	0.259000													4	115					0	0	0.009096	0	0
SLC17A4	10050	broad.mit.edu	37	6	25779395	25779395	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr6:25779395G>A	uc003nfe.2	+	12	1592	c.1473G>A	c.(1471-1473)GAG>GAA	p.E491E	SLC17A4_uc011djx.1_Silent_p.E261E|SLC17A4_uc003nfg.2_Silent_p.E428E|SLC17A4_uc010jqa.2_3'UTR	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	491					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						GGGCTAAAGAGCAGACATTCA	0.478000													48	106					0	0	0.048971	0	0
OR5V1	81696	broad.mit.edu	37	6	29323830	29323830	+	Missense_Mutation	SNP	G	A	A	rs150457685		TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr6:29323830G>A	uc011dlo.1	-	1	225	c.143C>T	c.(142-144)ACG>ATG	p.T48M		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						AGTCACAGTCGTCAAGATAAT	0.388000													4	133					0	0	0.014758	0	0
GNL1	2794	broad.mit.edu	37	6	30514076	30514076	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr6:30514076G>A	uc003nqh.2	-	12	2625	c.1597C>T	c.(1597-1599)CAT>TAT	p.H533Y	GNL1_uc011dmi.1_Missense_Mutation_p.H330Y|GNL1_uc011dmj.1_Missense_Mutation_p.H531Y|GNL1_uc011dmk.1_Missense_Mutation_p.H188Y	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	533					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						GTCTCTGGATGGGACTCCCAG	0.408000													5	11					0	0	0.021553	0	0
LY6G5C	80741	broad.mit.edu	37	6	31644773	31644773	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr6:31644773G>A	uc003nvu.1	-	3	405	c.405C>T	c.(403-405)TTC>TTT	p.F135F	LY6G5C_uc003nvw.1_RNA|LY6G5C_uc010jtb.1_RNA	NM_025262	NP_079538	Q5SRR4	LY65C_HUMAN	lymphocyte antigen 6 complex G5C	138	UPAR/Ly6.					extracellular region					0						GGTCATTGCAGAAATCCAGGA	0.463000													14	84					0	0	0.024245	0	0
RGL2	5863	broad.mit.edu	37	6	33260297	33260297	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr6:33260297T>C	uc003odv.2	-	17	2165	c.2032A>G	c.(2032-2034)AGT>GGT	p.S678G	RGL2_uc003odu.2_Missense_Mutation_p.S238G|RGL2_uc010jur.2_Missense_Mutation_p.S238G|RGL2_uc003odw.2_Missense_Mutation_p.S596G	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	678	Ras-associating.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						CTGATGACACTTGGAGCCTTG	0.522000													16	110					0	0	0.055883	0	0
GPR116	221395	broad.mit.edu	37	6	46847698	46847698	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr6:46847698A>G	uc003oyo.3	-	9	1182	c.893T>C	c.(892-894)TTG>TCG	p.L298S	GPR116_uc003oyp.3_Intron|GPR116_uc003oyq.3_Missense_Mutation_p.L298S|GPR116_uc010jzi.1_5'UTR|GPR116_uc003oyr.2_Missense_Mutation_p.L298S	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	298	Ig-like 1.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			ATTGGAGGACAAAACTTCCTT	0.423000													16	100					0	0	0.038395	0	0
HIVEP2	3097	broad.mit.edu	37	6	143089533	143089533	+	Silent	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr6:143089533T>C	uc003qjd.2	-	6	6071	c.5328A>G	c.(5326-5328)AAA>AAG	p.K1776K		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1776					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CTTCAAATATTTTAATTCGGA	0.363000													5	185					0	0	0.038147	0	0
TULP4	56995	broad.mit.edu	37	6	158914678	158914678	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr6:158914678C>T	uc003qrf.2	+	10	3062	c.1705C>T	c.(1705-1707)CCC>TCC	p.P569S	TULP4_uc003qrg.2_Missense_Mutation_p.P569S	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	569					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CCCACGGTTGCCCCTGCGCAA	0.642000													4	75					0	0	0.009096	0	0
ANKMY2	57037	broad.mit.edu	37	7	16650366	16650366	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr7:16650366T>C	uc003sti.2	-	6	754	c.554A>G	c.(553-555)AAT>AGT	p.N185S	ANKMY2_uc010ktz.2_RNA	NM_020319	NP_064715	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	185	ANK 3.					cilium	zinc ion binding			central_nervous_system(1)	1	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CAGCAGAGGATTCTCATTTAC	0.378000													12	70					0	0	0.024245	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579060	44579060	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr7:44579060G>T	uc003tlb.2	-	2	992	c.936C>A	c.(934-936)GAC>GAA	p.D312E	NPC1L1_uc003tlc.2_Missense_Mutation_p.D312E|NPC1L1_uc011kbw.1_Missense_Mutation_p.D312E|NPC1L1_uc003tld.2_Missense_Mutation_p.D312E	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	312	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	TCTTGCTTTTGTCCCTGGCGG	0.607000													6	98					0.00198382	0.00204217	0.029380	1	0
MYOM2	9172	broad.mit.edu	37	8	2048769	2048769	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr8:2048769C>T	uc003wpx.3	+	20	2682	c.2544C>T	c.(2542-2544)TTC>TTT	p.F848F	MYOM2_uc011kwi.1_Silent_p.F273F	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	848	Fibronectin type-III 5.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTGGATATTTCGTGGACTTCA	0.478000													9	60					0	0	0.093190	0	0
SNAI2	6591	broad.mit.edu	37	8	49833789	49833789	+	Silent	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr8:49833789G>A	uc003xqp.2	-	1	200	c.36C>T	c.(34-36)AAC>AAT	p.N12N		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	12					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				TTTTGGAGGCGTTGAAATGCT	0.532000													4	123					0	0	0.014758	0	0
NPBWR1	2831	broad.mit.edu	37	8	53852887	53852887	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr8:53852887C>T	uc011ldu.1	+	1	420	c.420C>T	c.(418-420)GCC>GCT	p.A140A		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	140	Cytoplasmic (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				TGGTGTTGGCCACTGCGGAGT	0.662000													7	42					0	0	0.047766	0	0
ZHX1	11244	broad.mit.edu	37	8	124266694	124266694	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr8:124266694A>G	uc003yqe.2	-	3	1923	c.1493T>C	c.(1492-1494)ATG>ACG	p.M498T	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.M498T|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.M498T	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	498	Homeobox 2.|Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGTTATTTTCATAAGTCTGAT	0.358000													18	221					0	0	0.083992	0	0
SH3GL2	6456	broad.mit.edu	37	9	17747099	17747099	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr9:17747099C>T	uc003zna.2	+	2	369	c.81C>T	c.(79-81)ACC>ACT	p.T27T	SH3GL2_uc011lmx.1_5'UTR|SH3GL2_uc011lmy.1_5'UTR	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	27	BAR.|Binds and tubulates liposomes (By similarity).				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		CTGAAGGAACCAAGCTAGATG	0.363000													5	50					0	0	0.021553	0	0
ACO1	48	broad.mit.edu	37	9	32436370	32436370	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr9:32436370C>T	uc003zqw.3	+	18	2377	c.2222C>T	c.(2221-2223)ACT>ATT	p.T741I	ACO1_uc010mjh.1_3'UTR|ACO1_uc003zqx.3_Missense_Mutation_p.T741I|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	741					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		GCACCACAGACTATCCATCTG	0.483000													6	196					0	0	0.038147	0	0
TMEM2	23670	broad.mit.edu	37	9	74359988	74359988	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr9:74359988A>G	uc011lsa.1	-	4	1520	c.980T>C	c.(979-981)ATC>ACC	p.I327T	TMEM2_uc010mos.2_Missense_Mutation_p.I327T|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	327						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		GATCATCTGGATGGTTCCTTG	0.522000													10	190					0	0	0.093190	0	0
TRPM6	140803	broad.mit.edu	37	9	77435241	77435241	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr9:77435241C>T	uc004ajl.1	-	9	1351	c.1113G>A	c.(1111-1113)GAG>GAA	p.E371E	TRPM6_uc004ajk.1_Silent_p.E366E|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.E371E|TRPM6_uc010mpd.1_Silent_p.E371E|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	371	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GAACCATACACTCCATTAGAA	0.363000													20	72					0	0	0.076483	0	0
CEP78	84131	broad.mit.edu	37	9	80881577	80881577	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr9:80881577T>C	uc004akx.2	+	15	2293	c.2017T>C	c.(2017-2019)TCC>CCC	p.S673P	CEP78_uc004aky.3_Missense_Mutation_p.S690P|CEP78_uc010mpp.2_Missense_Mutation_p.S674P|CEP78_uc004akz.1_Missense_Mutation_p.S161P	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	673					G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						AGAGGAGTTGTCCAGAAATAG	0.433000													2	12					0	0	0.004672	0	0
AMBP	259	broad.mit.edu	37	9	116840418	116840418	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr9:116840418C>T	uc004bie.3	-	1	335	c.72G>A	c.(70-72)ACG>ACA	p.T24T	AMBP_uc011lxk.1_5'Flank|AMBP_uc010mvc.1_RNA	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	24					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	TGTCGGGCGGCGTTGGCACAG	0.617000													5	91					0	0	0.014758	0	0
RXRA	6256	broad.mit.edu	37	9	137300950	137300950	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr9:137300950G>A	uc004cfb.2	+	4	757	c.595G>A	c.(595-597)GGC>AGC	p.G199S	RXRA_uc004cfc.1_Missense_Mutation_p.G102S	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	199	Nuclear receptor.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CCTGGCCATGGGCATGAAGCG	0.657000													5	64					0	0	0.014758	0	0
FAM47B	170062	broad.mit.edu	37	X	34962576	34962576	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chrX:34962576G>A	uc004ddi.1	+	1	1646	c.1628G>A	c.(1627-1629)CGT>CAT	p.R543H		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	543										ovary(3)|breast(1)	4						AGTGCACAGCGTGGGAGGATA	0.498000													6	70					0	0	0.029380	0	0
TBC1D25	4943	broad.mit.edu	37	X	48418056	48418056	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chrX:48418056C>T	uc004dka.1	+	6	871	c.760C>T	c.(760-762)CGG>TGG	p.R254W	TBC1D25_uc011mly.1_Missense_Mutation_p.R196W|TBC1D25_uc004dkb.1_5'UTR|TBC1D25_uc011mlz.1_5'UTR|TBC1D25_uc011mma.1_5'UTR|TBC1D25_uc004dkc.1_5'UTR|TBC1D25_uc011mmb.1_Missense_Mutation_p.R258W|TBC1D25_uc011mmc.1_5'UTR|TBC1D25_uc011mmd.1_5'UTR	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	254	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)	1						AGGCCGAGAGCGGATGGACTA	0.587000													24	35					0	0	0.034045	0	0
WAS	7454	broad.mit.edu	37	X	48545245	48545245	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chrX:48545245A>T	uc004dkm.3	+	7	692	c.635A>T	c.(634-636)TAC>TTC	p.Y212F		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	212					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				AGTTCACGATACCGTGGGCTC	0.572000			Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				5	44					0	0	0.021553	0	0
ALAS2	212	broad.mit.edu	37	X	55042060	55042060	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chrX:55042060C>T	uc004dua.3	-	8	1257	c.1119G>A	c.(1117-1119)GGG>GGA	p.G373G	ALAS2_uc004dub.3_Silent_p.G360G|ALAS2_uc004dud.3_Silent_p.G336G	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	373					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	CATCACGCTCCCCAATCCCAG	0.527000													22	73					0	0	0.034045	0	0
ATRX	546	broad.mit.edu	37	X	76909629	76909629	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chrX:76909629G>A	uc004ecp.3	-	14	4508	c.4276C>T	c.(4276-4278)CGA>TGA	p.R1426*	ATRX_uc004ecq.3_Nonsense_Mutation_p.R1388*|ATRX_uc004eco.3_Nonsense_Mutation_p.R1211*|ATRX_uc004ecr.2_Nonsense_Mutation_p.R1358*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1426					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTAATACGTCGCCTTTTCTTT	0.328000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						12	97					0	0	0.105934	0	0
TRPC5	7224	broad.mit.edu	37	X	111024435	111024435	+	Splice_Site	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chrX:111024435C>T	uc004epl.1	-	9	3020	c.2101_splice	c.e9-1	p.E701_splice	TRPC5_uc004epm.1_Intron	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,						axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						CATTGCGTTCCTATAATTGAA	0.403000													25	104					0	0	0.037714	0	0
ODZ1	10178	broad.mit.edu	37	X	123785903	123785903	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chrX:123785903C>T	uc004euj.2	-	8	1504	c.1440G>A	c.(1438-1440)CAG>CAA	p.Q480Q	ODZ1_uc011muj.1_Silent_p.Q479Q|ODZ1_uc010nqy.2_Silent_p.Q480Q	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	480	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GAGGGGAGTGCTGTGTATCAT	0.433000													4	56					0	0	0.009096	0	0
BRS3	680	broad.mit.edu	37	X	135574306	135574306	+	Silent	SNP	C	T	T			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chrX:135574306C>T	uc004ezv.1	+	3	1121	c.972C>T	c.(970-972)TGC>TGT	p.C324C		NM_001727	NP_001718	P32247	BRS3_HUMAN	bombesin-like receptor 3	324	Helical; Name=7; (Potential).				adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GCAATTCTTGCGTAAACCCCT	0.468000													7	178					0	0	0.029380	0	0
PCNX	22990	broad.mit.edu	37	14	71445338	71445338	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chr14:71445338delG	uc001xmo.2	+	6	2730	c.2284delG	c.(2284-2286)GGGfs	p.G762fs	PCNX_uc001xmn.3_Frame_Shift_Del_p.G762fs|PCNX_uc010are.1_Frame_Shift_Del_p.G762fs	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	762						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		ATTTCCTGAAGGGGAAGAGCA	0.418													22	182	---	---	---	---					
SHROOM4	57477	broad.mit.edu	37	X	50377586	50377586	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DU-8167-01A-11D-2253-08	TCGA-DU-8167-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	abec779c-5d98-4e48-ae7f-33158ced8b86	3c841a53-9778-4460-89ac-4fb1d9dd5f73	g.chrX:50377586delG	uc004dpe.2	-	4	1513	c.1487delC	c.(1486-1488)CCAfs	p.P496fs	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Frame_Shift_Del_p.P380fs	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	496					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CTCTCCATGTGGGGGACTGCT	0.527													18	100	---	---	---	---					
