Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1P9	11223	broad.mit.edu	37	1	17087308	17087308	+	Silent	SNP	C	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr1:17087308C>T	uc010ock.1	-	3	276	c.276G>A	c.(274-276)TCG>TCA	p.S92S	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'Flank	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TTGAGTGGGGCGAGTGTTGAG	0.627													13	85					0	0	0.539581	0	0
ZMYM6	9204	broad.mit.edu	37	1	35476495	35476495	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr1:35476495C>T	uc001byh.2	-	9	1433	c.1205G>A	c.(1204-1206)CGT>CAT	p.R402H	ZMYM6_uc001byf.1_Missense_Mutation_p.R402H|ZMYM6_uc010oht.1_Missense_Mutation_p.R305H|ZMYM6_uc009vup.2_Missense_Mutation_p.R208H|ZMYM6_uc009vuq.1_Missense_Mutation_p.R402H|ZMYM6_uc009vur.1_Missense_Mutation_p.R208H	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	402	MYM-type 5.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				AGCAGAGCCACGGATGGAGCT	0.547													8	68					0	0	0.307466	0	0
SEC16B	89866	broad.mit.edu	37	1	177909803	177909803	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr1:177909803C>T	uc001gli.1	-	17	2159	c.2069G>A	c.(2068-2070)CGC>CAC	p.R690H	SEC16B_uc001glk.1_Missense_Mutation_p.R367H|SEC16B_uc009wwy.1_Missense_Mutation_p.R245H|SEC16B_uc001glh.1_Missense_Mutation_p.R349H|SEC16B_uc009wwz.1_Missense_Mutation_p.R349H|SEC16B_uc001glj.1_Missense_Mutation_p.R691H	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	690					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						GTCTCCACTGCGTCTTTCTAA	0.507													21	22					0	0	0.706142	0	0
NID1	4811	broad.mit.edu	37	1	236144995	236144995	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr1:236144995G>A	uc001hxo.2	-	16	3245	c.3143C>T	c.(3142-3144)GCG>GTG	p.A1048V	NID1_uc009xgd.2_Missense_Mutation_p.A915V|NID1_uc009xgc.2_Missense_Mutation_p.A129V	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	1048	LDL-receptor class B 2.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GTCCAGCTTCGCCACTTCTAT	0.498													22	38					0	0	0.706142	0	0
RYR2	6262	broad.mit.edu	37	1	237754205	237754205	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr1:237754205G>A	uc001hyl.1	+	31	4193	c.4073G>A	c.(4072-4074)CGT>CAT	p.R1358H		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1358	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTGCCCGATCGTGTTGACAAA	0.428													8	22					0	0	0.307466	0	0
MYO3A	53904	broad.mit.edu	37	10	26432481	26432481	+	Silent	SNP	A	G	G			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr10:26432481A>G	uc001isn.2	+	21	2727	c.2367A>G	c.(2365-2367)CTA>CTG	p.L789L	MYO3A_uc009xko.1_Silent_p.L789L|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	789	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TACTTTCCCTACTTGATGAAG	0.403													21	30					0	0	0.693898	0	0
SPDYC	387778	broad.mit.edu	37	11	64939962	64939962	+	Silent	SNP	A	G	G			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr11:64939962A>G	uc010rnz.1	+	5	402	c.402A>G	c.(400-402)CCA>CCG	p.P134P		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C	134	Speedy/Ringo box; Required for CDK- binding (By similarity).				cell cycle	nucleus	protein kinase binding				0						AGATTTTTCCATGGGCCCTGG	0.562													44	87					0	0	0.870114	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714797	92714797	+	Silent	SNP	T	C	C			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr11:92714797T>C	uc001pdk.1	+	2	511	c.408T>C	c.(406-408)ATT>ATC	p.I136I		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	136	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CCATCGCCATTAACCGCTACT	0.607													6	54					0	0	0.248553	0	0
EML5	161436	broad.mit.edu	37	14	89093251	89093251	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr14:89093251G>C	uc001xxg.2	-	35	4857	c.4671C>G	c.(4669-4671)AGC>AGG	p.S1557R	EML5_uc001xxf.2_Missense_Mutation_p.S344R|EML5_uc001xxh.1_Missense_Mutation_p.S688R	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1549	WD 22.					cytoplasm|microtubule				ovary(3)	3						GCCCTTTTTTGCTAAGAAGAG	0.463													17	30					0	0	0.539581	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32917835	32917835	+	Splice_Site	SNP	G	C	C			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr15:32917835G>C	uc001zgy.1	+	6	1584	c.862_splice	c.e6+1	p.D288_splice	ARHGAP11A_uc010ubw.1_Splice_Site_p.D99_splice|ARHGAP11A_uc001zgw.2_Splice_Site_p.D288_splice|ARHGAP11A_uc001zgx.2_Splice_Site_p.D288_splice|ARHGAP11A_uc010ubx.1_Splice_Site_p.D99_splice	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		AGTGTAGGAGGTAAGTGGCGG	0.408													7	90					0	0	0.307466	0	0
SOLH	6650	broad.mit.edu	37	16	598068	598068	+	Silent	SNP	C	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr16:598068C>T	uc002chi.2	+	4	1593	c.1230C>T	c.(1228-1230)CCC>CCT	p.P410P	SOLH_uc002chh.1_Silent_p.P410P	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	410					proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				GCGTCCTGCCCGAGCGCCCGG	0.751													8	12					0	0	0.335167	0	0
SF3B3	23450	broad.mit.edu	37	16	70594469	70594469	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr16:70594469G>A	uc002ezf.2	+	16	2319	c.2108G>A	c.(2107-2109)CGA>CAA	p.R703Q		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	703					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				AAGCTCTTCCGAGTCCGAATG	0.522													4	73					0	0	0.184627	0	0
PRDM7	11105	broad.mit.edu	37	16	90126912	90126912	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr16:90126912G>T	uc010cje.2	-	9	1090	c.1070C>A	c.(1069-1071)TCT>TAT	p.S357Y	PRDM7_uc002fqo.2_Intron|PRDM7_uc010cjf.2_Intron|PRDM7_uc010cjg.1_Missense_Mutation_p.S151Y	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	357	SET.			S -> Y (in Ref. 2; AAF78084).		chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCATCCCCAGACCAGACCAG	0.532													5	71					0.000157383	0.000168364	0.278610	1	0
TP53	7157	broad.mit.edu	37	17	7579350	7579350	+	Missense_Mutation	SNP	A	C	C			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr17:7579350A>C	uc002gim.2	-	4	531	c.337T>G	c.(337-339)TTC>GTC	p.F113V	TP53_uc002gig.1_Missense_Mutation_p.F113V|TP53_uc002gih.2_Missense_Mutation_p.F113V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.F113V|TP53_uc010cni.1_Missense_Mutation_p.F113V|TP53_uc002gij.2_Missense_Mutation_p.F113V|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.F74V|TP53_uc010cnk.1_Missense_Mutation_p.F128V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	113	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).		F -> L (in sporadic cancers; somatic mutation).|F -> C (in sporadic cancers; somatic mutation).|F -> V (in sporadic cancers; somatic mutation).|F -> G (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|F -> S (in sporadic cancers; somatic mutation).|F -> I (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.F113C(8)|p.0?(7)|p.F113S(4)|p.F113V(4)|p.F113L(3)|p.G59fs*23(3)|p.F113del(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G112_V122delGFLHSGTAKSV(1)|p.G112fs*9(1)|p.Y107fs*44(1)|p.G112_S116delGFLHS(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAATGCAAGAAGCCCAGACGG	0.607		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			55	26					0	0	0.870114	0	0
MYH10	4628	broad.mit.edu	37	17	8397110	8397110	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr17:8397110C>G	uc002gll.2	-	30	4153	c.4057G>C	c.(4057-4059)GAG>CAG	p.E1353Q	MYH10_uc002glm.2_Missense_Mutation_p.E1384Q|MYH10_uc010cnx.2_Missense_Mutation_p.E1362Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1353	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TCCTCCTCCTCCTGCTGCTCC	0.587													3	44					0	0	0.115264	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904139	21904139	+	RNA	SNP	T	G	G			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr17:21904139T>G	uc002gza.2	+	1		c.78T>G				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						ccgagcaggatgaggaaacca	0													5	162					0	0	0.217242	0	0
GPATCH8	23131	broad.mit.edu	37	17	42483311	42483311	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr17:42483311C>G	uc002igw.1	-	7	665	c.601G>C	c.(601-603)GAG>CAG	p.E201Q	GPATCH8_uc002igv.1_Missense_Mutation_p.E123Q|GPATCH8_uc010wiz.1_Missense_Mutation_p.E123Q	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	201						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TTTCTTTGCTCTGCCAACTCA	0.353													10	63					0	0	0.387290	0	0
PRKCA	5578	broad.mit.edu	37	17	64738870	64738870	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr17:64738870G>A	uc002jfp.1	+	13	1560	c.1516G>A	c.(1516-1518)GCC>ACC	p.A506T	PRKCA_uc002jfo.1_Missense_Mutation_p.A377T	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	506	Protein kinase.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	AGATTATATCGCCCCAGAGGT	0.448													9	18					0	0	0.361761	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887461	9887461	+	Missense_Mutation	SNP	A	C	C			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr18:9887461A>C	uc002koi.3	+	2	1434	c.985A>C	c.(985-987)ATC>CTC	p.I329L	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.I262L	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	329	15.|22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						GGAGGGTGACATCCCCAAGTC	0.592													4	124					0	0	0.150653	0	0
KLHL14	57565	broad.mit.edu	37	18	30322013	30322013	+	Splice_Site	SNP	C	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr18:30322013C>A	uc002kxm.1	-	3	1336	c.948_splice	c.e3-1	p.R316_splice	KLHL14_uc010dmd.1_Splice_Site	NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14							cytosol|endoplasmic reticulum membrane				ovary(1)	1						AGAGCGAATTCTTCACCCAAA	0.433													9	58					0.000978159	0.00102262	0.387290	1	0
PSG1	5669	broad.mit.edu	37	19	43382350	43382350	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr19:43382350T>C	uc002ovb.2	-	2	283	c.145A>G	c.(145-147)AAG>GAG	p.K49E	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.K49E|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.K49E|PSG1_uc010eio.1_Missense_Mutation_p.K49E|PSG1_uc002oux.1_5'UTR|PSG1_uc002ouy.1_Missense_Mutation_p.K49E|PSG1_uc002ouz.1_Missense_Mutation_p.K49E|PSG1_uc002ova.1_Missense_Mutation_p.K49E|PSG1_uc002ovc.2_Missense_Mutation_p.K49E|PSG1_uc002ovd.1_Missense_Mutation_p.K49E	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	49	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				AGAACATCCTTCCCCTCGGAA	0.473													35	264					0	0	0.859065	0	0
ZNF761	388561	broad.mit.edu	37	19	53958931	53958931	+	Silent	SNP	C	G	G			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr19:53958931C>G	uc010eqp.2	+	7	1628	c.1170C>G	c.(1168-1170)ACC>ACG	p.T390T	ZNF761_uc010ydy.1_Silent_p.T336T|ZNF761_uc002qbt.1_Silent_p.T336T	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	390	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		GTGGCAAGACCTTTAGTCACA	0.408													12	140					0	0	0.500413	0	0
LRP1B	53353	broad.mit.edu	37	2	141607789	141607789	+	Silent	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr2:141607789G>A	uc002tvj.1	-	29	5793	c.4821C>T	c.(4819-4821)GAC>GAT	p.D1607D	LRP1B_uc010fnl.1_Silent_p.D789D	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1607	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCACAGTAACGTCATCAATAT	0.368										TSP Lung(27;0.18)			10	44					0	0	0.387290	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								23	43					0	0	0.740014	0	0
CHGB	1114	broad.mit.edu	37	20	5902992	5902992	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr20:5902992G>A	uc002wmg.2	+	4	508	c.202G>A	c.(202-204)GTC>ATC	p.V68I	CHGB_uc010zqz.1_Intron	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	68						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						TAGAAAAGACGTCAAAGACAA	0.408													4	30					0	0	0.150653	0	0
ZNF860	344787	broad.mit.edu	37	3	32032046	32032046	+	Missense_Mutation	SNP	G	A	A	rs143925165	by1000genomes	TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr3:32032046G>A	uc011axg.1	+	2	2024	c.1475G>A	c.(1474-1476)CGT>CAT	p.R492H		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	492	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAGACCTTCCGTCACAATTCA	0.403													4	82					0	0	0.150653	0	0
OR5K4	403278	broad.mit.edu	37	3	98073379	98073379	+	Missense_Mutation	SNP	A	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr3:98073379A>T	uc011bgv.1	+	1	682	c.682A>T	c.(682-684)ATG>TTG	p.M228L		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TGTTTTCAAAATGAAATCCAA	0.338													3	30					0	0	0.150653	0	0
ADAM29	11086	broad.mit.edu	37	4	175898893	175898893	+	Silent	SNP	C	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr4:175898893C>T	uc003iuc.2	+	5	2887	c.2217C>T	c.(2215-2217)TCC>TCT	p.S739S	ADAM29_uc003iud.2_Silent_p.S739S|ADAM29_uc010irr.2_Silent_p.S739S|ADAM29_uc011cki.1_Silent_p.S739S	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	739	Cytoplasmic (Potential).|9 X 9 AA approximate repeats.|1.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGATGCCTTCCCAGAGTCAAC	0.527													5	134					0	0	0.278610	0	0
SNX18	112574	broad.mit.edu	37	5	53815358	53815358	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr5:53815358C>G	uc003jpj.3	+	1	1766	c.1576C>G	c.(1576-1578)CAG>GAG	p.Q526E	SNX18_uc011cqg.1_Missense_Mutation_p.Q526E|SNX18_uc003jpi.3_Missense_Mutation_p.Q526E	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	526	BAR.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				AGCGCTGTATCAGGGGCATCT	0.557													6	117					0	0	0.307466	0	0
IBTK	25998	broad.mit.edu	37	6	82912294	82912294	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr6:82912294A>G	uc003pjl.1	-	18	3207	c.2680T>C	c.(2680-2682)TCT>CCT	p.S894P	IBTK_uc011dyu.1_5'UTR|IBTK_uc011dyv.1_Missense_Mutation_p.S894P|IBTK_uc011dyw.1_Missense_Mutation_p.S693P|IBTK_uc010kbi.1_Missense_Mutation_p.S588P|IBTK_uc003pjm.2_Missense_Mutation_p.S894P	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	894					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TGTAAACAAGACAGTTTCAAC	0.343													14	111					0	0	0.479597	0	0
SLC35F1	222553	broad.mit.edu	37	6	118588282	118588282	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr6:118588282G>A	uc003pxx.3	+	4	803	c.602G>A	c.(601-603)GGA>GAA	p.G201E	SLC35F1_uc003pxy.1_Missense_Mutation_p.G6E	NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	201	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		TGCATGGTGGGAGCAGATGTG	0.537													8	170					0	0	0.278610	0	0
WNT2	7472	broad.mit.edu	37	7	116937826	116937826	+	Silent	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr7:116937826G>A	uc003viz.2	-	4	993	c.693C>T	c.(691-693)GGC>GGT	p.G231G	WNT2_uc003vja.2_Silent_p.G135G	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	231					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		AGAGATAATCGCCCGTTTTCC	0.532													5	100					0	0	0.184627	0	0
EPHB6	2051	broad.mit.edu	37	7	142562152	142562152	+	Silent	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr7:142562152G>A	uc011kst.1	+	7	1381	c.594G>A	c.(592-594)GAG>GAA	p.E198E	EPHB6_uc011ksu.1_Silent_p.E198E|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_Intron|EPHB6_uc003wbu.2_5'UTR|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	198	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					ACGTCAAAGAGCGGAGCTTTG	0.552													11	254					0	0	0.479597	0	0
NKX3-1	4824	broad.mit.edu	37	8	23539038	23539038	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr8:23539038G>A	uc011kzx.1	-	2	449	c.401C>T	c.(400-402)ACT>ATT	p.T134I	NKX3-1_uc003xdv.1_Intron	NM_006167	NP_006158	Q99801	NKX31_HUMAN	NK3 homeobox 1	134	Homeobox.				negative regulation of estrogen receptor binding|negative regulation of transcription, DNA-dependent|positive regulation of cell division|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	nucleus	estrogen receptor activity|estrogen receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region sequence-specific DNA binding				0		Prostate(55;0.114)		Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)|BRCA - Breast invasive adenocarcinoma(99;0.0708)		GATCACCTGAGTGTGGGAGAA	0.577													14	117					0	0	0.500413	0	0
FAM189A2	9413	broad.mit.edu	37	9	72000864	72000864	+	Splice_Site	SNP	G	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr9:72000864G>T	uc010mon.1	+	9	960	c.856_splice	c.e9+1	p.A286_splice	FAM189A2_uc004ahg.2_Splice_Site_p.A286_splice|FAM189A2_uc010moo.1_Splice_Site_p.D121_splice	NM_001127608	NP_001121080	Q15884	F1892_HUMAN	chromosome 9 open reading frame 61 precursor							integral to membrane					0						GAGGAGAGAGGTGATGTCATT	0.577													15	35					2.23348e-06	2.4462e-06	0.500413	1	0
CDK16	5127	broad.mit.edu	37	X	47082981	47082981	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chrX:47082981C>T	uc004dho.2	+	2	421	c.25C>T	c.(25-27)CGG>TGG	p.R9W	CDK16_uc011mli.1_Missense_Mutation_p.R15W|CDK16_uc011mlj.1_Missense_Mutation_p.R9W|CDK16_uc011mlk.1_Missense_Mutation_p.R9W|CDK16_uc011mll.1_Missense_Mutation_p.R83W	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	9							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						GAAGATCAAACGGCAGCTGTC	0.532													3	24					0	0	0.184627	0	0
ACRC	93953	broad.mit.edu	37	X	70823916	70823916	+	Missense_Mutation	SNP	A	T	T			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chrX:70823916A>T	uc004eae.2	+	8	1290	c.789A>T	c.(787-789)GAA>GAT	p.E263D	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	263	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					ATGATTCGGAAGCTCCCGACG	0.552													3	41					0	0	0.184627	0	0
ATRX	546	broad.mit.edu	37	X	76909629	76909629	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chrX:76909629G>A	uc004ecp.3	-	14	4508	c.4276C>T	c.(4276-4278)CGA>TGA	p.R1426*	ATRX_uc004ecq.3_Nonsense_Mutation_p.R1388*|ATRX_uc004eco.3_Nonsense_Mutation_p.R1211*|ATRX_uc004ecr.2_Nonsense_Mutation_p.R1358*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1426					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTAATACGTCGCCTTTTCTTT	0.328			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						33	12					0	0	0.827153	0	0
FAF1	11124	broad.mit.edu	37	1	50907162	50907162	+	Frame_Shift_Del	DEL	C	-	-			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr1:50907162delC	uc009vyx.1	-	20	1966	c.1903delG	c.(1903-1905)GAGfs	p.E635fs	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Frame_Shift_Del_p.E635fs|FAF1_uc010onc.1_Frame_Shift_Del_p.E393fs	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	635	UBX.				apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		AACTTTACCTCCAATAATGAT	0.423													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	21847949	21847967	+	RNA	DEL	GCGGCCCCCGCAGACGCTC	-	-			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr16:21847949_21847967delGCGGCCCCCGCAGACGCTC	uc002diq.3	+	3		c.1842_1860delGCGGCCCCCGCAGACGCTC			uc010vbm.1_5'UTR|uc002djn.3_Intron					Homo sapiens cDNA FLJ59829 complete cds.																		GAGGGTGGAAGCGGCCCCCGCAGACGCTCGGCAGGTGTC	0.566													3	4	---	---	---	---					
REXO1	57455	broad.mit.edu	37	19	1827021	1827023	+	In_Frame_Del	DEL	GGA	-	-			TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr19:1827021_1827023delGGA	uc002lua.3	-	2	1860_1862	c.1765_1767delTCC	c.(1765-1767)TCCdel	p.S589del	REXO1_uc010dsr.1_In_Frame_Del_p.S543del	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	589	Ser-rich.					nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCTggaggtggaggaggaggag	0.463													3	3	---	---	---	---					
CAMSAP1	157922	broad.mit.edu	37	9	138715799	138715800	+	Frame_Shift_Ins	INS	-	T	T	rs148250832	byFrequency	TCGA-FG-8191-01A-11D-2253-08	TCGA-FG-8191-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcc461af-d70d-4fca-ae7f-3f09367b6d51	6a19fe53-192d-492a-98ba-54d24a6f3574	g.chr9:138715799_138715800insT	uc004cgr.3	-	10	1396_1397	c.1396_1397insA	c.(1396-1398)ACCfs	p.T466fs	CAMSAP1_uc004cgq.3_Frame_Shift_Ins_p.T356fs|CAMSAP1_uc010nbg.2_Frame_Shift_Ins_p.T188fs	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	466						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GACTCACCTGGTTTTTTTTTCT	0.337													2	4	---	---	---	---					
