Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARID1A	8289	broad.mit.edu	37	1	27105550	27105550	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr1:27105550C>T	uc001bmv.1	+	20	5534	c.5161C>T	c.(5161-5163)CGA>TGA	p.R1721*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.R1504*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.R567*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.R49*|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1721					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.R1721*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGAATATTTCCGACGATGCCT	0.443000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								22	158					0	0	0.069288	0	0
LPHN2	23266	broad.mit.edu	37	1	82408735	82408735	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr1:82408735C>G	uc001dit.3	+	6	661	c.480C>G	c.(478-480)TGC>TGG	p.C160W	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.C160W|LPHN2_uc001div.2_Missense_Mutation_p.C160W|LPHN2_uc009wcd.2_Missense_Mutation_p.C160W	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	160	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GTGCTTGGTGCAAGGACCCTC	0.408000													9	38					0	0	0.047766	0	0
BRSK2	9024	broad.mit.edu	37	11	1477639	1477639	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr11:1477639C>T	uc001lti.2	+	17	2116	c.1730C>T	c.(1729-1731)ACG>ATG	p.T577M	BRSK2_uc009ycv.1_Missense_Mutation_p.T599M|BRSK2_uc001lth.1_Missense_Mutation_p.T577M|BRSK2_uc001ltj.2_Missense_Mutation_p.T577M|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Missense_Mutation_p.T577M|BRSK2_uc001ltm.2_Missense_Mutation_p.T623M|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA|BRSK2_uc009ycw.2_Missense_Mutation_p.T73M	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	577					establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		TACAAGGCCACGGGGGGGCCA	0.622000													4	13					0	0	0.009096	0	0
OR5M8	219484	broad.mit.edu	37	11	56258086	56258086	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr11:56258086A>G	uc001nix.1	-	1	761	c.761T>C	c.(760-762)CTT>CCT	p.L254P		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					CATGAAGAAAAGGGTTGCATA	0.418000													3	50					0	0	0.004672	0	0
LOC220429	220429	broad.mit.edu	37	13	50466990	50466990	+	Missense_Mutation	SNP	T	C	C	rs144184696	by1000genomes	TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr13:50466990T>C	uc001vdk.2	+	1	2446	c.2264T>C	c.(2263-2265)CTG>CCG	p.L755P		NR_003268				Homo sapiens CTAGE family, member 5 pseudogene, mRNA (cDNA clone IMAGE:5270026).												0						GTCTGTCCACTGAGGGGTTTT	0.517000													6	100					0	0	0.058154	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21792899	21792899	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr14:21792899G>A	uc001wag.2	+	14	1885	c.1885G>A	c.(1885-1887)GAA>AAA	p.E629K	RPGRIP1_uc001wah.2_Missense_Mutation_p.E271K|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001waj.1_Missense_Mutation_p.E94K|RPGRIP1_uc001wak.2_Missense_Mutation_p.E104K|RPGRIP1_uc010aim.2_Missense_Mutation_p.E12K|RPGRIP1_uc001wal.2_Intron|RPGRIP1_uc001wam.2_5'UTR	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	629					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GAATCTTTTTGAACTGCACAT	0.498000													5	94					0	0	0.014758	0	0
C17orf53	78995	broad.mit.edu	37	17	42225428	42225428	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr17:42225428C>T	uc002ifi.1	+	3	442	c.257C>T	c.(256-258)ACG>ATG	p.T86M	C17orf53_uc010czq.1_Missense_Mutation_p.T86M|C17orf53_uc002ifj.1_Missense_Mutation_p.T86M|C17orf53_uc002ifk.1_RNA	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	86											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GCCTCCAGCACGCCCAGTGCT	0.602000													39	66					0	0	0.104719	0	0
JAK3	3718	broad.mit.edu	37	19	17945744	17945744	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr19:17945744C>A	uc002nhn.3	-	16	2216	c.2116G>T	c.(2116-2118)GCT>TCT	p.A706S	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Missense_Mutation_p.A706S	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	706	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CACTTGTCAGCTTCCAAGCTA	0.617000		2	Mis		acute megakaryocytic leukemia|								27	37					1.77063e-15	1.97494e-15	0.108266	1	0
CIC	23152	broad.mit.edu	37	19	42791757	42791757	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr19:42791757C>T	uc002otf.1	+	5	683	c.643C>T	c.(643-645)CGG>TGG	p.R215W		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	215	HMG box.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CAAGCGGCACCGGGCCCTGGT	0.612000			T	DUX4	soft tissue sarcoma								34	13					0	0	0.064281	0	0
GALNT5	11227	broad.mit.edu	37	2	158152216	158152216	+	Missense_Mutation	SNP	G	A	A	rs138347479		TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr2:158152216G>A	uc002tzg.2	+	4	2038	c.1783G>A	c.(1783-1785)GTT>ATT	p.V595I	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	595	Catalytic subdomain A.|Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						GGAATGTAACGTTGGTTGGTT	0.358000													8	201					0	0	0.047766	0	0
TTN	7273	broad.mit.edu	37	2	179434377	179434377	+	Silent	SNP	G	A	A			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr2:179434377G>A	uc010zfg.1	-	275	69002	c.68778C>T	c.(68776-68778)GAC>GAT	p.D22926D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.D16621D|TTN_uc010zfi.1_Silent_p.D16554D|TTN_uc010zfj.1_Silent_p.D16429D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23853							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCAGGGACGTCAGCATGTT	0.373000													5	17					0	0	0.014758	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								27	48					0	0	0.041601	0	0
CECR2	27443	broad.mit.edu	37	22	18028150	18028150	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr22:18028150T>C	uc010gqw.1	+	16	3233	c.3107T>C	c.(3106-3108)ATT>ACT	p.I1036T	CECR2_uc010gqv.1_Missense_Mutation_p.I894T|CECR2_uc002zml.2_Missense_Mutation_p.I895T|CECR2_uc002zmo.2_RNA	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1078					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		AACGGAGTCATTGGGGAAGCA	0.622000													3	32					0	0	0.004672	0	0
SCN11A	11280	broad.mit.edu	37	3	38936278	38936278	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr3:38936278G>T	uc011ays.1	-	15	2780	c.2581C>A	c.(2581-2583)CAA>AAA	p.Q861K	SCN11A_uc010hhn.1_5'UTR	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	861					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GGTAAGTTTTGCTTCCTGCAC	0.488000													42	62					2.24722e-20	2.71539e-20	0.048971	1	0
PIK3CA	5290	broad.mit.edu	37	3	178952072	178952072	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr3:178952072A>G	uc003fjk.2	+	21	3284	c.3127A>G	c.(3127-3129)ATG>GTG	p.M1043V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1043	PI3K/PI4K.		M -> I (in cancer; shows an increase in lipid kinase activity).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.M1043I(31)|p.M1043V(15)|p.M1043T(3)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CATGAAACAAATGAATGATGC	0.368000		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			40	44					0	0	0.092188	0	0
CRIPAK	285464	broad.mit.edu	37	4	1388948	1388948	+	Missense_Mutation	SNP	A	C	C	rs140577610	byFrequency	TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr4:1388948A>C	uc003gdf.2	+	1	3609	c.649A>C	c.(649-651)AGT>CGT	p.S217R		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	217					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GCCCATGTGGAGTGTTCGCCT	0.662000													4	22					0	0	0.009096	0	0
TNXB	7148	broad.mit.edu	37	6	32053695	32053695	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr6:32053695G>A	uc003nzl.2	-	7	3182	c.2980C>T	c.(2980-2982)CGC>TGC	p.R994C		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1081	Fibronectin type-III 3.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACCCGCATGCGCAGTTGGAAG	0.672000													33	42					0	0	0.092188	0	0
C7orf63	79846	broad.mit.edu	37	7	89929253	89929253	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr7:89929253G>A	uc010lep.2	+	17	2181	c.1930G>A	c.(1930-1932)GCT>ACT	p.A644T	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_Missense_Mutation_p.A319T|C7orf63_uc011khj.1_Missense_Mutation_p.A626T|C7orf63_uc011khk.1_Missense_Mutation_p.A206T	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	644							binding			ovary(1)	1						CAAAACTGCAGCTCATGTCAA	0.348000													20	20					0	0	0.043863	0	0
SLC13A1	6561	broad.mit.edu	37	7	122768985	122768985	+	Silent	SNP	C	T	T			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr7:122768985C>T	uc003vkm.2	-	10	1072	c.1047G>A	c.(1045-1047)GTG>GTA	p.V349V	SLC13A1_uc010lks.2_Silent_p.V225V	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	349	Helical; (Potential).					integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	GGACCAAGGTCACAATTTCTT	0.418000													13	20					0	0	0.093190	0	0
NIPBL	25836	broad.mit.edu	37	5	37048690	37048693	+	Frame_Shift_Del	DEL	TCAG	-	-			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr5:37048690_37048693delTCAG	uc003jkl.3	+	39	7175_7178	c.6676_6679delTCAG	c.(6676-6681)TCAGTCfs	p.S2226fs	NIPBL_uc003jkk.3_Frame_Shift_Del_p.S2226fs|NIPBL_uc003jkn.2_5'Flank	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2226_2227	HEAT 4.				brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TAAGAACTCCTCAGTCAATTTAAA	0.353													25	37	---	---	---	---					
TDRD6	221400	broad.mit.edu	37	6	46660414	46660415	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-7468-01A-11D-2024-08	TCGA-HT-7468-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	053517e5-fb21-4127-b893-bdda23e4de42	219554d7-3116-498e-8f48-05286e616cc7	g.chr6:46660414_46660415insA	uc003oyj.2	+	1	4549_4550	c.4549_4550insA	c.(4549-4551)GAAfs	p.E1517fs	TDRD6_uc010jze.2_Frame_Shift_Ins_p.E1511fs	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1517					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GTATAATCCAGAAAAAAAAATG	0.351													7	95	---	---	---	---					
