Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FUBP1	8880	broad.mit.edu	37	1	78430773	78430773	+	Nonsense_Mutation	SNP	C	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr1:78430773C>A	uc001dii.2	-	8	705	c.616G>T	c.(616-618)GAA>TAA	p.E206*	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Nonsense_Mutation_p.E227*	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	206	KH 2.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						TTAATAGTTTCTCCCCCTTTT	0.393000													105	29					3.41453e-61	3.71581e-61	0.870114	1	0
KIAA1324	57535	broad.mit.edu	37	1	109707134	109707134	+	Silent	SNP	C	T	T	rs144842352		TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr1:109707134C>T	uc001dwq.2	+	4	424	c.288C>T	c.(286-288)AAC>AAT	p.N96N	KIAA1324_uc009wex.1_Silent_p.N96N|KIAA1324_uc009wey.2_Silent_p.N96N|KIAA1324_uc010ovg.1_Translation_Start_Site	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	96	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		TCTCCTGCAACGCCGGGGAGT	0.592000													76	18					0	0	0.870114	0	0
ADCY10	55811	broad.mit.edu	37	1	167870912	167870912	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr1:167870912G>A	uc001ger.2	-	5	722	c.424C>T	c.(424-426)CGA>TGA	p.R142*	ADCY10_uc009wvk.2_Nonsense_Mutation_p.R50*|ADCY10_uc010plj.1_Intron|ADCY10_uc009wvl.2_Nonsense_Mutation_p.R141*|ADCY10_uc009wvm.2_Intron	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	142	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						ATCTTGACTCGGATGTCTAGG	0.463000													76	84					0	0	0.870114	0	0
CACNA1E	777	broad.mit.edu	37	1	181765891	181765891	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr1:181765891G>A	uc001gow.2	+	46	6332	c.6167G>A	c.(6166-6168)CGC>CAC	p.R2056H	CACNA1E_uc009wxs.2_Missense_Mutation_p.R1944H|CACNA1E_uc009wxt.2_Missense_Mutation_p.R1325H	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2099	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GATGTCTCCCGCTGCAATTCA	0.602000													3	15					0	0	0.115264	0	0
MYO3A	53904	broad.mit.edu	37	10	26500833	26500833	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr10:26500833G>A	uc001isn.2	+	35	5152	c.4792G>A	c.(4792-4794)GAC>AAC	p.D1598N	MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.R613Q	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1598					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						CAACCCCTACGACTTCAGGAG	0.652000													5	11					0	0	0.217242	0	0
CHST15	51363	broad.mit.edu	37	10	125780796	125780796	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr10:125780796G>C	uc001lhl.2	-	5	1836	c.1323C>G	c.(1321-1323)AAC>AAG	p.N441K	CHST15_uc001lhm.2_Missense_Mutation_p.N441K|CHST15_uc001lhn.2_Missense_Mutation_p.N441K|CHST15_uc010que.1_Missense_Mutation_p.N441K|CHST15_uc001lho.2_Missense_Mutation_p.N441K	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	441	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						TGAGGGTGTTGTTGTAGACGC	0.542000													10	10					0	0	0.335167	0	0
LOC650368	650368	broad.mit.edu	37	11	3427759	3427759	+	RNA	SNP	C	T	T			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr11:3427759C>T	uc010qxs.1	+	9		c.752C>T			LOC650368_uc001lxx.2_RNA|LOC650368_uc001lxy.2_RNA	NR_024248				Homo sapiens cDNA FLJ41654 fis, clone FEBRA2025463, weakly  similar to Homo sapiens HMT-1 mRNA for beta-1,4 mannosyltransferase.												0						TGTCTGCACACGTCCTGCAGT	0.612000													3	89					0	0	0.115264	0	0
LOC650368	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	C	C			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr11:3427765G>C	uc010qxs.1	+	9		c.758G>C			LOC650368_uc001lxx.2_RNA|LOC650368_uc001lxy.2_RNA	NR_024248				Homo sapiens cDNA FLJ41654 fis, clone FEBRA2025463, weakly  similar to Homo sapiens HMT-1 mRNA for beta-1,4 mannosyltransferase.												0						CACACGTCCTGCAGTGGCCTG	0.602000													4	96					0	0	0.150653	0	0
ETS1	2113	broad.mit.edu	37	11	128426243	128426243	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr11:128426243A>G	uc001qej.2	-	3	242	c.157T>C	c.(157-159)TTT>CTT	p.F53L		NM_001143820	NP_001137292	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		TCATCCCAAAAGGGGTAGCAA	0.448000													3	82					0	0	0.115264	0	0
PZP	5858	broad.mit.edu	37	12	9309931	9309931	+	Silent	SNP	G	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr12:9309931G>A	uc001qvl.2	-	28	3419	c.3390C>T	c.(3388-3390)GCC>GCT	p.A1130A	PZP_uc009zgl.2_Silent_p.A916A	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						GGCAGAACAGGGCATTGCGAA	0.507000													4	122					0	0	0.184627	0	0
CCNT1	904	broad.mit.edu	37	12	49087565	49087565	+	Nonsense_Mutation	SNP	C	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr12:49087565C>A	uc001rse.1	-	9	1755	c.1432G>T	c.(1432-1434)GAG>TAG	p.E478*	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Nonsense_Mutation_p.E193*	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	478					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						TTTATCTCCTCTGGTTTTGAA	0.453000													36	65					1.836e-18	1.94092e-18	0.788014	1	0
NAB2	4665	broad.mit.edu	37	12	57485439	57485439	+	Silent	SNP	G	C	C			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr12:57485439G>C	uc001smz.2	+	2	993	c.615G>C	c.(613-615)TCG>TCC	p.S205S		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	205					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						AGGCTGGCTCGCCCCCCTTCT	0.726000													4	11					0	0	0.217242	0	0
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr12:57485446T>C	uc001smz.2	+	2	1000	c.622T>C	c.(622-624)TTC>CTC	p.F208L		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTCGCCCCCCTTCTCCCCCCC	0.716000													3	10					0	0	0.248553	0	0
CHRNA3	1136	broad.mit.edu	37	15	78894483	78894483	+	Silent	SNP	C	T	T			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr15:78894483C>T	uc002bec.2	-	5	687	c.501G>A	c.(499-501)CCG>CCA	p.P167P	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Silent_p.P167P	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	167	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						GGTAATCAAACGGGAAGTAGG	0.483000													28	137					0	0	0.769981	0	0
MYH4	4622	broad.mit.edu	37	17	10355562	10355562	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr17:10355562C>T	uc002gmn.2	-	27	3545	c.3434G>A	c.(3433-3435)CGG>CAG	p.R1145Q	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1145	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CTCCAGCTCCCGGGAGAGGTC	0.592000													6	155					0	0	0.278610	0	0
TMC8	147138	broad.mit.edu	37	17	76130033	76130033	+	Silent	SNP	G	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr17:76130033G>A	uc002jup.2	+	7	1150	c.768G>A	c.(766-768)GTG>GTA	p.V256V	TMC6_uc002jul.1_5'Flank|TMC8_uc002juq.2_Silent_p.V33V|TMC8_uc010wtr.1_5'Flank	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	256	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			GCATCCGGGTGCAGGAAGCAG	0.577000									Epidermodysplasia_Verruciformis_Familial_Clustering_of				31	35					0	0	0.788014	0	0
GATA6	2627	broad.mit.edu	37	18	19751533	19751533	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr18:19751533A>G	uc002ktt.1	+	2	693	c.428A>G	c.(427-429)CAG>CGG	p.Q143R	GATA6_uc002ktu.1_Missense_Mutation_p.Q143R	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	143					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			GCACCCGAGCAGCCGGAGGAG	0.657000													6	33					0	0	0.248553	0	0
MUC16	94025	broad.mit.edu	37	19	9090831	9090831	+	Silent	SNP	A	G	G			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr19:9090831A>G	uc002mkp.2	-	1	1188	c.984T>C	c.(982-984)CCT>CCC	p.P328P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	328	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCATGGAAAAAGGGATAGCTG	0.522000													4	76					0	0	0.150653	0	0
GLT25D1	79709	broad.mit.edu	37	19	17690296	17690296	+	Silent	SNP	G	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr19:17690296G>A	uc002nhc.1	+	10	1284	c.1272G>A	c.(1270-1272)GTG>GTA	p.V424V	GLT25D1_uc010eax.1_Silent_p.V152V|GLT25D1_uc010eay.1_5'Flank	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	424					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0						CTCAGGTGGTGGACCGGGGGC	0.562000													29	42					0	0	0.693898	0	0
ATP13A1	57130	broad.mit.edu	37	19	19758334	19758334	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr19:19758334G>A	uc002nnh.3	-	21	2825	c.2797C>T	c.(2797-2799)CGC>TGC	p.R933C	ATP13A1_uc002nne.2_Missense_Mutation_p.R73C|ATP13A1_uc002nnf.3_Missense_Mutation_p.R301C|ATP13A1_uc002nng.2_Missense_Mutation_p.R815C	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	ATPase type 13A1	933	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(3)|large_intestine(2)|central_nervous_system(1)	6						TGGCTCAGGCGGTCCTGCAGG	0.637000													3	22					0	0	0.115264	0	0
ZNF761	388561	broad.mit.edu	37	19	53959188	53959188	+	Missense_Mutation	SNP	G	A	A	rs144532705		TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr19:53959188G>A	uc010eqp.2	+	7	1885	c.1427G>A	c.(1426-1428)CGT>CAT	p.R476H	ZNF761_uc010ydy.1_Missense_Mutation_p.R422H|ZNF761_uc002qbt.1_Missense_Mutation_p.R422H	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	476	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AAAGCTTTCCGTTTCAAATCA	0.423000													36	2					0	0	0.769981	0	0
ZNF814	730051	broad.mit.edu	37	19	58386284	58386284	+	Silent	SNP	T	C	C	rs148592080	by1000genomes	TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr19:58386284T>C	uc002qqo.2	-	3	746	c.474A>G	c.(472-474)GCA>GCG	p.A158A	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	158				A -> V (in Ref. 1; BAH13293).	regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TACACCTCTTTGCAAACAACG	0.493000													2	6					0	0	0.115264	0	0
POTEF	728378	broad.mit.edu	37	2	130877893	130877893	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr2:130877893G>A	uc010fmh.2	-	3	596	c.196C>T	c.(196-198)CGC>TGC	p.R66C		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	66						cell cortex	ATP binding			skin(3)|ovary(2)	5						AAGCAGTGGCGGCACCACTTG	0.602000													6	275					0	0	0.248553	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								42	54					0	0	0.870114	0	0
SON	6651	broad.mit.edu	37	21	34924118	34924118	+	Missense_Mutation	SNP	A	G	G	rs142324795		TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr21:34924118A>G	uc002yse.1	+	3	2630	c.2581A>G	c.(2581-2583)ATG>GTG	p.M861V	SON_uc002ysb.1_Missense_Mutation_p.M861V|SON_uc002ysc.2_Missense_Mutation_p.M861V|SON_uc002ysd.2_Intron|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	861	17 X 10 AA tandem repeats of L-A-[ST]- [NSG]-[TS]-MDSQM.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						AACTAGCTCAATGGATTCCCA	0.493000													81	112					0	0	0.870114	0	0
LRRC3	81543	broad.mit.edu	37	21	45876870	45876870	+	Silent	SNP	C	T	T	rs138458454		TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr21:45876870C>T	uc002zfa.2	+	2	636	c.343C>T	c.(343-345)CTG>TTG	p.L115L		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	115	LRR 3.					integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		GGCCGGGGGCCTGCGGCTGCT	0.672000													4	49					0	0	0.150653	0	0
STAB1	23166	broad.mit.edu	37	3	52552602	52552602	+	Silent	SNP	C	T	T			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr3:52552602C>T	uc003dej.2	+	47	4934	c.4860C>T	c.(4858-4860)CAC>CAT	p.H1620H	STAB1_uc003dek.1_5'Flank|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1620	Extracellular (Potential).|FAS1 5.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TCGTGCCGCACGCAGATCTAA	0.627000													4	7					0	0	0.248553	0	0
SLC6A3	6531	broad.mit.edu	37	5	1409836	1409836	+	Silent	SNP	G	A	A	rs2270912	byFrequency	TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr5:1409836G>A	uc003jck.2	-	10	1519	c.1398C>T	c.(1396-1398)AAC>AAT	p.N466N		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	466					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	TGGTACGTACGTTGGTGACGC	0.617000													34	44					0	0	0.840704	0	0
TTYH3	80727	broad.mit.edu	37	7	2698612	2698612	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr7:2698612A>G	uc003smp.2	+	13	1650	c.1463A>G	c.(1462-1464)AAC>AGC	p.N488S	TTYH3_uc010ksn.2_Missense_Mutation_p.N208S|TTYH3_uc003smq.2_Missense_Mutation_p.N317S	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	488	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		CGCTGTGAGAACACCCCACTC	0.642000													95	131					0	0	0.870114	0	0
C7orf42	55069	broad.mit.edu	37	7	66416082	66416082	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr7:66416082A>G	uc003tvk.2	+	5	1004	c.740A>G	c.(739-741)TAT>TGT	p.Y247C	C7orf42_uc010lah.2_Intron|C7orf42_uc003tvl.2_Missense_Mutation_p.Y247C	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	247	Helical; (Potential).					integral to membrane				ovary(1)	1						GGAAAAGTCTATCATGCTTTA	0.313000													34	56					0	0	0.796494	0	0
NCF1B	654816	broad.mit.edu	37	7	72640036	72640036	+	Silent	SNP	T	C	C			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr7:72640036T>C	uc011kes.1	+	3	271	c.267T>C	c.(265-267)CTT>CTC	p.L89L	FKBP6_uc003twz.2_Intron|NCF1B_uc011ker.1_Silent_p.L91L	NM_000265	NP_000256			neutrophil cytosolic factor 1												0						CCCACCTCCTTGACTTCTTCA	0.507000													7	47					0	0	0.248553	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070969	141070969	+	Silent	SNP	A	G	G			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr9:141070969A>G	uc004com.2	+	4	633	c.372A>G	c.(370-372)GCA>GCG	p.A124A	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TAGAAAACGCAGATGAGACCT	0.517000													3	30					0	0	0.150653	0	0
MXRA5	25878	broad.mit.edu	37	X	3238337	3238337	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chrX:3238337C>T	uc004crg.3	-	5	5546	c.5389G>A	c.(5389-5391)GGA>AGA	p.G1797R		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1797						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GAGGGTGATCCCGTGGTCTGC	0.493000													20	23					0	0	0.575678	0	0
RBM4	5936	broad.mit.edu	37	11	66411034	66411035	+	Frame_Shift_Ins	INS	-	CGATAGAT	CGATAGAT			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr11:66411034_66411035insCGATAGAT	uc009yrj.2	+	3	1014_1015	c.526_527insCGATAGAT	c.(526-528)CCGfs	p.P176fs	RBM4_uc009yrk.2_Frame_Shift_Ins_p.P151fs|RBM4_uc001oiw.1_Frame_Shift_Ins_p.P176fs|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_Frame_Shift_Ins_p.P176fs|RBM4_uc001oiz.1_Frame_Shift_Ins_p.P176fs	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	176	CCHC-type.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		CAAAGAGTGTCCGATAGATCGT	0.579													14	85	---	---	---	---					
VEZF1	7716	broad.mit.edu	37	17	56056605	56056607	+	In_Frame_Del	DEL	TGC	-	-	rs61731354	byFrequency	TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr17:56056605_56056607delTGC	uc002ivf.1	-	5	1187_1189	c.1044_1046delGCA	c.(1042-1047)CAGCAA>CAA	p.348_349QQ>Q	VEZF1_uc010dcn.1_In_Frame_Del_p.198_199QQ>Q	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	348_349	Poly-Gln.				cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ttgttgttgttgctgctgctgct	0.305													9	252	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42794411	42794411	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chr19:42794411delT	uc002otf.1	+	10	1531	c.1491delT	c.(1489-1491)CCTfs	p.P497fs		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	497					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TGTTTTCACCTGTGATCCGTT	0.617			T	DUX4	soft tissue sarcoma								82	27	---	---	---	---					
CD99L2	83692	broad.mit.edu	37	X	149984524	149984526	+	In_Frame_Del	DEL	GTG	-	-			TCGA-HT-7471-01A-11D-2253-08	TCGA-HT-7471-10B-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	06425414-a57c-40df-905e-290fa2086153	d0b349eb-d50b-43ec-903d-e8494d8705ca	g.chrX:149984524_149984526delGTG	uc004fel.2	-	3	274_276	c.156_158delCAC	c.(154-159)ACCACA>ACA	p.52_53TT>T	CD99L2_uc004fek.2_5'Flank|CD99L2_uc004fem.2_Intron|CD99L2_uc004fen.2_Intron|CD99L2_uc004feo.2_RNA|CD99L2_uc011myb.1_In_Frame_Del_p.52_53TT>T	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4	52_53	Extracellular (Potential).|Poly-Thr.				cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATTGGTTGTGGTGGTGGTGG	0.552													7	428	---	---	---	---					
