Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR51I1	390063	broad.mit.edu	37	11	5462039	5462039	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr11:5462039G>A	uc010qze.1	-	1	706	c.706C>T	c.(706-708)CGG>TGG	p.R236W	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCTTGAGCCGCTGTTCCTGG	0.478000													3	20					0	0	0.115264	0	0
ABTB2	25841	broad.mit.edu	37	11	34182569	34182569	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr11:34182569G>A	uc001mvl.1	-	11	1950	c.1720C>T	c.(1720-1722)CGG>TGG	p.R574W		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	574							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				ACCGAGTACCGCGACTGCGAG	0.617000													3	21					0	0	0.115264	0	0
CPSF7	79869	broad.mit.edu	37	11	61183777	61183777	+	Silent	SNP	A	G	G			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr11:61183777A>G	uc001nrq.2	-	6	899	c.765T>C	c.(763-765)CCT>CCC	p.P255P	CPSF7_uc001nro.2_Silent_p.P246P|CPSF7_uc001nrp.2_Silent_p.P298P|CPSF7_uc001nrr.2_Silent_p.P246P|CPSF7_uc001nrs.1_Silent_p.P156P	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	255	Pro-rich.				mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						GAGGAGGAGGAGGGACCCCAA	0.617000													3	68					0	0	0.029380	0	0
PITPNM1	9600	broad.mit.edu	37	11	67269773	67269773	+	Silent	SNP	C	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr11:67269773C>T	uc001olx.2	-	3	594	c.405G>A	c.(403-405)CAG>CAA	p.Q135Q	PITPNM1_uc001oly.2_Silent_p.Q135Q|PITPNM1_uc001olz.2_Silent_p.Q135Q	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	135					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						CCAGGATGCGCTGTCTCCTCT	0.612000													23	53					0	0	0.108266	0	0
HEPHL1	341208	broad.mit.edu	37	11	93822035	93822035	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr11:93822035T>C	uc001pep.2	+	12	2352	c.2195T>C	c.(2194-2196)ATA>ACA	p.I732T	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	732	Plastocyanin-like 5.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TACGGGATGATAAGAACTTTT	0.517000													23	65					0	0	0.099896	0	0
Unknown	0	broad.mit.edu	37	12	9717870	9717870	+	RNA	SNP	A	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr12:9717870A>T	uc001qwb.1	+	6		c.4299A>T								Homo sapiens mRNA; cDNA DKFZp686A1124 (from clone DKFZp686A1124).																		CCAACGGATGAATTCCCATGG	0.448000													16	16					0	0	0.038395	0	0
GJB2	2706	broad.mit.edu	37	13	20763148	20763148	+	Silent	SNP	G	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr13:20763148G>A	uc001umy.2	-	2	788	c.573C>T	c.(571-573)TTC>TTT	p.F191F		NM_004004	NP_003995	P29033	CXB2_HUMAN	gap junction protein beta 2	191	Extracellular (Potential).		F -> L.		cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane					0		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		TGAACACTGTGAAGACAGTCT	0.488000									Keratitis_Ichthyosis_and_Deafness_syndrome				4	66					0	0	0.014758	0	0
GJB2	2706	broad.mit.edu	37	13	20763400	20763400	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr13:20763400G>C	uc001umy.2	-	2	536	c.321C>G	c.(319-321)ATC>ATG	p.I107M		NM_004004	NP_003995	P29033	CXB2_HUMAN	gap junction protein beta 2	107	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane					0		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		TCTCCCCCTTGATGAACTTCC	0.547000									Keratitis_Ichthyosis_and_Deafness_syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	74					0	0	0.115264	0	0
IPO5	3843	broad.mit.edu	37	13	98658457	98658457	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr13:98658457A>G	uc001vnf.1	+	14	1636	c.1571A>G	c.(1570-1572)GAA>GGA	p.E524G	IPO5_uc001vne.2_Missense_Mutation_p.E542G|IPO5_uc010tik.1_Missense_Mutation_p.E399G|IPO5_uc010til.1_Missense_Mutation_p.E464G|IPO5_uc001vng.1_Missense_Mutation_p.E145G	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	524					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						GATACTGCAGAAGAAAAATTT	0.388000													15	150					0	0	0.043863	0	0
MCTP2	55784	broad.mit.edu	37	15	94841633	94841633	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr15:94841633C>T	uc002btj.2	+	1	204	c.139C>T	c.(139-141)CGT>TGT	p.R47C	MCTP2_uc010urg.1_Missense_Mutation_p.R47C|MCTP2_uc002bti.2_Missense_Mutation_p.R47C|MCTP2_uc010boj.2_5'UTR|MCTP2_uc010bok.2_Missense_Mutation_p.R47C|MCTP2_uc002btg.3_Missense_Mutation_p.R47C|MCTP2_uc002bth.3_Missense_Mutation_p.R47C	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	47					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CTTGGACCGCCGTCTCAGCCT	0.592000													6	54					0	0	0.029380	0	0
Unknown	0	broad.mit.edu	37	16	66940	66940	+	Silent	SNP	G	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr16:66940G>A	uc002cfg.1	-	5	1355	c.696C>T	c.(694-696)AGC>AGT	p.S232S		NM_182905	NP_878908			WAS protein family homolog 1																		GCTCTCTCTTGCTGATGGACA	0.597000													7	54					0	0	0.093190	0	0
CPNE2	221184	broad.mit.edu	37	16	57147304	57147304	+	Silent	SNP	C	G	G			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr16:57147304C>G	uc002eks.1	+	3	514	c.285C>G	c.(283-285)CTC>CTG	p.L95L	CPNE2_uc010cct.1_Silent_p.L121L|CPNE2_uc010ccu.1_Silent_p.L95L	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	95	C2 1.									central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				AGTTCGCGCTCTTTGACCAGG	0.582000													9	53					0	0	0.047766	0	0
LOC283922	283922	broad.mit.edu	37	16	74372644	74372644	+	Silent	SNP	A	G	G			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr16:74372644A>G	uc002fcr.2	-	9	1661	c.315T>C	c.(313-315)CCT>CCC	p.P105P	LOC283922_uc010vms.1_RNA					Homo sapiens cDNA FLJ39449 fis, clone PROST2008360, highly similar to Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit (PDPR), mRNA.												0						TACCCTTGTCAGGGGGAACAA	0.443000													3	37					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	12					0	0	0.055883	0	0
SLC6A4	6532	broad.mit.edu	37	17	28545875	28545875	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr17:28545875C>T	uc002hey.3	-	4	962	c.418G>A	c.(418-420)GGA>AGA	p.G140R		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	140					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	TGGTACTGTCCCAGTGCGAGC	0.507000													64	140					0	0	0.139131	0	0
SMARCE1	6605	broad.mit.edu	37	17	38792704	38792704	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr17:38792704C>T	uc002hux.2	-	6	436	c.312G>A	c.(310-312)TGG>TGA	p.W104*	SMARCE1_uc010wff.1_Nonsense_Mutation_p.W69*|SMARCE1_uc010wfg.1_Nonsense_Mutation_p.W34*|SMARCE1_uc002huy.2_Nonsense_Mutation_p.W69*|SMARCE1_uc010wfh.1_Nonsense_Mutation_p.W34*|SMARCE1_uc010wfi.1_Nonsense_Mutation_p.W86*|SMARCE1_uc002huz.1_Nonsense_Mutation_p.W69*|SMARCE1_uc010wfj.1_Nonsense_Mutation_p.W86*	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	104	HMG box.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				TGAGATCTCGCCACATGCCAC	0.408000													8	149					0	0	0.038147	0	0
PRKAR1A	5573	broad.mit.edu	37	17	66525030	66525030	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr17:66525030A>T	uc002jhg.2	+	9	969	c.789A>T	c.(787-789)GAA>GAT	p.E263D	PRKAR1A_uc002jhh.2_Missense_Mutation_p.E263D|PRKAR1A_uc002jhi.2_Missense_Mutation_p.E263D|PRKAR1A_uc002jhj.2_Missense_Mutation_p.E263D|PRKAR1A_uc002jhk.2_Missense_Mutation_p.E139D|PRKAR1A_uc002jhl.2_Missense_Mutation_p.E263D|PRKAR1A_uc002jhm.2_Missense_Mutation_p.E263D	NM_212471	NP_997636	P10644	KAP0_HUMAN	cAMP-dependent protein kinase, regulatory	263	cAMP 2.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|lung(3)|thyroid(2)|soft_tissue(2)|breast(1)	12	Breast(10;1.64e-13)					ACAAGTGGGAACGTCTTACGG	0.398000			T|Mis|N|F|S	RET	papillary thyroid	myxoma|endocrine|papillary thyroid			Carney_Complex|Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial|Cardiac_Myxomas_Familial_Clustering_of				13	115					0	0	0.132662	0	0
SDK2	54549	broad.mit.edu	37	17	71418471	71418471	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr17:71418471G>A	uc010dfm.2	-	15	2000	c.2000C>T	c.(1999-2001)GCC>GTC	p.A667V	SDK2_uc010dfn.2_Missense_Mutation_p.A346V	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	667	Extracellular (Potential).|Fibronectin type-III 1.				cell adhesion	integral to membrane				ovary(2)	2						GTCGTTGACGGCACAAAGACG	0.617000													4	82					0	0	0.014758	0	0
LLGL2	3993	broad.mit.edu	37	17	73567818	73567818	+	Silent	SNP	G	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr17:73567818G>A	uc002joh.2	+	18	2401	c.2247G>A	c.(2245-2247)GTG>GTA	p.V749V	LLGL2_uc002joi.2_Silent_p.V749V|LLGL2_uc010dgg.1_Silent_p.V749V|LLGL2_uc002joj.2_Silent_p.V738V|LLGL2_uc010wsd.1_Silent_p.V376V	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	749	WD 11.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CCCTGCGTGTGCCTCCCGCCG	0.672000													7	72					0	0	0.058154	0	0
LAMA1	284217	broad.mit.edu	37	18	6986294	6986294	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr18:6986294C>T	uc002knm.2	-	37	5315	c.5221G>A	c.(5221-5223)GAA>AAA	p.E1741K	LAMA1_uc010wzj.1_Missense_Mutation_p.E1217K	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1741	Domain II and I.|Potential.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCCAATTCTTCCAGCGGCTTC	0.428000													4	94					0	0	0.009096	0	0
ZNF57	126295	broad.mit.edu	37	19	2917807	2917807	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr19:2917807A>C	uc002lwr.2	+	4	1336	c.1188A>C	c.(1186-1188)CAA>CAC	p.Q396H	ZNF57_uc010xha.1_Missense_Mutation_p.Q364H	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	396	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AATGTGAACAATGTGGGAAGG	0.428000													4	91					0	0	0.009096	0	0
LIPE	3991	broad.mit.edu	37	19	42930578	42930579	+	Missense_Mutation	DNP	AA	TT	TT			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr19:42930578_42930579AA>TT	uc002otr.2	-	1	1000_1001	c.723_724TT>AA	c.(721-726)TCTTCA>TCAACA	p.S242T	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	242					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TCTGTGTCTGAAGATGATCCCA	0.475000													41	59					0	0	0.115264	0	0
ZNF845	91664	broad.mit.edu	37	19	53855364	53855365	+	Missense_Mutation	DNP	CA	TG	TG			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr19:53855364_53855365CA>TG	uc010ydv.1	+	4	1553_1554	c.1436_1437CA>TG	c.(1435-1437)ACA>ATG	p.T479M	ZNF845_uc010ydw.1_Missense_Mutation_p.T479M	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	479	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCAGTCAGACATCATCCCTTG	0.381000													3	91					0	0	0.115264	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	G	G			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358000													2	3					0	0	0.115264	0	0
TTN	7273	broad.mit.edu	37	2	179404218	179404218	+	Silent	SNP	T	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr2:179404218T>C	uc010zfg.1	-	301	91094	c.90870A>G	c.(90868-90870)AAA>AAG	p.K30290K	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.K23985K|TTN_uc010zfi.1_Silent_p.K23918K|TTN_uc010zfj.1_Silent_p.K23793K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31217							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTGAGGCCTTTTACCACCA	0.458000													3	136					0	0	0.009096	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								29	85					0	0	0.080422	0	0
FAM83D	81610	broad.mit.edu	37	20	37580459	37580459	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr20:37580459G>A	uc002xjg.2	+	4	1185	c.1144G>A	c.(1144-1146)GCA>ACA	p.A382T		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	352					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				AGAGATGCCCGCAGAGGGCAA	0.602000													3	81					0	0	0.009096	0	0
ADCY5	111	broad.mit.edu	37	3	123008730	123008730	+	Silent	SNP	G	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr3:123008730G>A	uc003egh.1	-	19	3399	c.3399C>T	c.(3397-3399)TCC>TCT	p.S1133S	ADCY5_uc003egg.1_Silent_p.S791S	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1133	Cytoplasmic (Potential).|Guanylate cyclase 2.				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding	p.S1133S(1)		ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		CGTTGAGGCCGGAGGCAGCCA	0.557000													3	82					0	0	0.115264	0	0
PLD1	5337	broad.mit.edu	37	3	171427368	171427368	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr3:171427368T>C	uc003fhs.2	-	10	1159	c.1043A>G	c.(1042-1044)GAG>GGG	p.E348G	PLD1_uc003fht.2_Missense_Mutation_p.E348G	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	348					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TAAAGCATTCTCTTGGATAGC	0.413000													34	84					0	0	0.092188	0	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	G	G	rs144273946	by1000genomes	TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr3:197348674A>G	uc011bug.1	-	4		c.417T>C			LOC220729_uc003fxw.2_RNA|LOC220729_uc003fxy.2_RNA|LOC220729_uc010iao.1_Intron					Homo sapiens cDNA FLJ60865 complete cds, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1).												0						GGCTCTGTCCACCAAATGCAC	0.478000													4	92					0	0	0.021553	0	0
ZNF721	170960	broad.mit.edu	37	4	436647	436647	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr4:436647C>T	uc003gag.2	-	3	2300	c.1609G>A	c.(1609-1611)GCC>ACC	p.A537T	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.A569T|ZNF721_uc010ibe.2_Missense_Mutation_p.A525T	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	537						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TGTCTAAAGGCTTTGCCACAT	0.408000													4	147					0	0	0.038147	0	0
ZNF721	170960	broad.mit.edu	37	4	436658	436658	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr4:436658A>T	uc003gag.2	-	3	2289	c.1598T>A	c.(1597-1599)GTA>GAA	p.V533E	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.V565E|ZNF721_uc010ibe.2_Missense_Mutation_p.V521E	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	533						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TTTGCCACATACTTCACATGT	0.398000													4	144					0	0	0.029380	0	0
APBB2	323	broad.mit.edu	37	4	41015610	41015610	+	Silent	SNP	C	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr4:41015610C>T	uc003gvl.2	-	6	1455	c.825G>A	c.(823-825)CCG>CCA	p.P275P	APBB2_uc003gvm.2_Silent_p.P275P|APBB2_uc003gvn.2_Silent_p.P275P|APBB2_uc011byt.1_Silent_p.P258P	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	275					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						CTGTTTCATCCGGGGAGCTGG	0.512000													54	142					0	0	0.139131	0	0
GABRA1	2554	broad.mit.edu	37	5	161324271	161324271	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr5:161324271A>T	uc010jiw.2	+	11	1682	c.1214A>T	c.(1213-1215)AAA>ATA	p.K405I	GABRA1_uc010jix.2_Missense_Mutation_p.K405I|GABRA1_uc010jiy.2_Missense_Mutation_p.K405I|GABRA1_uc003lyx.3_Missense_Mutation_p.K405I|GABRA1_uc010jiz.2_Missense_Mutation_p.K405I|GABRA1_uc010jja.2_Missense_Mutation_p.K405I|GABRA1_uc010jjb.2_Missense_Mutation_p.K405I	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	405	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CCCGAAACAAAACCACCAGAA	0.473000													5	118					0	0	0.021553	0	0
TCP10L2	401285	broad.mit.edu	37	6	167592524	167592524	+	Missense_Mutation	SNP	T	C	C	rs2989545	by1000genomes	TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr6:167592524T>C	uc010kkp.2	+	6	814	c.683T>C	c.(682-684)CTG>CCG	p.L228P		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	228											0						TCCCGAAGTCTGCAAAACTCC	0.602000													3	31					0	0	0.115264	0	0
NOM1	64434	broad.mit.edu	37	7	156742958	156742958	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr7:156742958T>C	uc003wmy.2	+	1	542	c.527T>C	c.(526-528)TTA>TCA	p.L176S		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	176	Necessary for nucleolar localization and for targeting PPP1CA to the nucleolus.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		CGGGCGCTTTTAGCGGCGAAC	0.672000													17	62					0	0	0.062417	0	0
KCNB2	9312	broad.mit.edu	37	8	73849082	73849082	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr8:73849082G>C	uc003xzb.2	+	3	2080	c.1492G>C	c.(1492-1494)GCT>CCT	p.A498P		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	498	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GGCCAGGAAGGCTCTGTCGGA	0.542000													36	94					0	0	0.104719	0	0
TCEB1	6921	broad.mit.edu	37	8	74858991	74858991	+	Silent	SNP	C	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr8:74858991C>T	uc003xzx.1	-	4	298	c.213G>A	c.(211-213)TCG>TCA	p.S71S	TCEB1_uc003xzy.1_Silent_p.S71S|TCEB1_uc003xzz.1_Silent_p.S55S|TCEB1_uc003yaa.1_Silent_p.S71S	NM_005648	NP_005639	Q15369	ELOC_HUMAN	elongin C	71					interspecies interaction between organisms|positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm	protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0136)|all cancers(69;0.0431)|BRCA - Breast invasive adenocarcinoma(89;0.0499)			TGCATACTTTCGATAGCACAT	0.373000													3	52					0	0	0.115264	0	0
COL14A1	7373	broad.mit.edu	37	8	121238908	121238908	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr8:121238908C>T	uc003yox.2	+	16	2172	c.1907C>T	c.(1906-1908)ACG>ATG	p.T636M	COL14A1_uc003yoy.2_Missense_Mutation_p.T314M	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	636	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GATGAGGTGACGACAGACAGT	0.483000													25	51					0	0	0.134883	0	0
KIAA0196	9897	broad.mit.edu	37	8	126075804	126075804	+	Silent	SNP	G	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr8:126075804G>C	uc003yrt.2	-	11	1697	c.1368C>G	c.(1366-1368)GTC>GTG	p.V456V	KIAA0196_uc011lir.1_Silent_p.V308V|KIAA0196_uc003yru.1_Silent_p.V30V	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	456					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTCCTGAAAAGACATCAGCAA	0.423000													59	125					0	0	0.139131	0	0
DENND4C	55667	broad.mit.edu	37	9	19336296	19336296	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr9:19336296G>A	uc003znq.2	+	15	1943	c.1910G>A	c.(1909-1911)AGT>AAT	p.S637N	DENND4C_uc011lnc.1_5'UTR|DENND4C_uc011lnd.1_5'Flank	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	637						integral to membrane				ovary(1)|skin(1)	2						TGGCCTAGCAGTACCCGCAGT	0.393000													3	71					0	0	0.014758	0	0
IFNA21	3452	broad.mit.edu	37	9	21166611	21166611	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr9:21166611T>C	uc003zom.2	-	1	49	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_002175	NP_002166	P01568	IFN21_HUMAN	interferon, alpha 21 precursor	1					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GACAGGGCCATTGGGATGTTG	0.488000													25	58					0	0	0.050027	0	0
AKAP4	8852	broad.mit.edu	37	X	49957504	49957504	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chrX:49957504G>C	uc004dow.1	-	5	1984	c.1860C>G	c.(1858-1860)GAC>GAG	p.D620E	AKAP4_uc004dov.1_Missense_Mutation_p.D237E|AKAP4_uc010njp.1_Missense_Mutation_p.D442E|AKAP4_uc004dou.1_Missense_Mutation_p.D611E	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	620					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					TTTTCTGGGAGTCCAGGTGTT	0.463000													9	208					0	0	0.058154	0	0
KLHL13	90293	broad.mit.edu	37	X	117032912	117032912	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chrX:117032912T>G	uc004eql.2	-	7	1989	c.1927A>C	c.(1927-1929)ACA>CCA	p.T643P	KLHL13_uc004eqk.2_Missense_Mutation_p.T592P|KLHL13_uc011mtn.1_Missense_Mutation_p.T483P|KLHL13_uc011mto.1_Missense_Mutation_p.T637P|KLHL13_uc011mtp.1_Missense_Mutation_p.T645P|KLHL13_uc004eqm.2_Missense_Mutation_p.T592P|KLHL13_uc011mtq.1_Missense_Mutation_p.T627P	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	643					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						GGTGATGGTGTGGTTTCTTCT	0.418000													12	135					0	0	0.093190	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150530506	150530506	+	Frame_Shift_Del	DEL	G	-	-	rs149280379		TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr1:150530506delG	uc001eux.2	+	14	2499	c.2263delG	c.(2263-2265)GGGfs	p.G755fs	ADAMTSL4_uc001euw.2_Frame_Shift_Del_p.G755fs|ADAMTSL4_uc009wlw.2_Frame_Shift_Del_p.G778fs|ADAMTSL4_uc010pcg.1_Frame_Shift_Del_p.G716fs|ADAMTSL4_uc009wlx.2_5'UTR	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	755	TSP type-1 2.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GCAGGAATTTGGGGGGGGTGG	0.692													8	191	---	---	---	---					
EMG1	10436	broad.mit.edu	37	12	7080212	7080213	+	Splice_Site	INS	-	C	C	rs17857448		TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr12:7080212_7080213insC	uc001qsh.3	+	2	272	c.129_splice	c.e2+1	p.L43_splice	PHB2_uc001qsd.2_5'Flank|PHB2_uc010sft.1_5'Flank|PHB2_uc010sfu.1_5'Flank|EMG1_uc009zfo.2_RNA|EMG1_uc010sfv.1_RNA	NM_006331	NP_006322	Q92979	NEP1_HUMAN	ribosome biogenesis protein NEP1						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding				0						GAGGCCGTAGTTTATTGTGGTG	0.569													7	29	---	---	---	---					
ACVRL1	94	broad.mit.edu	37	12	52309001	52309008	+	Splice_Site	DEL	GCACACAG	-	-			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr12:52309001_52309008delGCACACAG	uc001rzj.2	+	7	1056	c.773_splice	c.e7-1	p.G258_splice	ACVRL1_uc001rzk.2_Splice_Site_p.G258_splice|ACVRL1_uc010snm.1_Splice_Site_p.G84_splice	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor						blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CAACCTTTCTGCACACAGGCTTCATCGC	0.370									Hereditary_Hemorrhagic_Telangiectasia				8	38	---	---	---	---					
TCF12	6938	broad.mit.edu	37	15	57555366	57555369	+	Frame_Shift_Del	DEL	AAAG	-	-			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr15:57555366_57555369delAAAG	uc002aec.2	+	17	1851_1854	c.1567_1570delAAAG	c.(1567-1572)AAAGAAfs	p.K523fs	TCF12_uc010ugm.1_Frame_Shift_Del_p.K575fs|TCF12_uc010ugn.1_Frame_Shift_Del_p.K543fs|TCF12_uc002aea.2_Frame_Shift_Del_p.K547fs|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Frame_Shift_Del_p.K547fs|TCF12_uc002aed.2_Frame_Shift_Del_p.K523fs|TCF12_uc002aee.2_Frame_Shift_Del_p.K353fs|TCF12_uc010bft.2_Frame_Shift_Del_p.K377fs|TCF12_uc010ugo.1_Frame_Shift_Del_p.K287fs|TCF12_uc010ugp.1_Frame_Shift_Del_p.K181fs|TCF12_uc010ugq.1_Frame_Shift_Del_p.K157fs|TCF12_uc010ugr.1_Frame_Shift_Del_p.K136fs	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	523_524					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		GACTGAAAACAAAGAAAAGGATGA	0.382			T	TEC	extraskeletal myxoid chondrosarcoma								17	25	---	---	---	---					
UHRF1BP1	54887	broad.mit.edu	37	6	34803152	34803152	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr6:34803152delA	uc003oju.3	+	7	985	c.751delA	c.(751-753)AAGfs	p.K251fs	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	251										ovary(3)	3						CTCACAGCTCAAGGCTATGAT	0.493													11	162	---	---	---	---					
NCR2	9436	broad.mit.edu	37	6	41303645	41303647	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr6:41303645_41303647delCTG	uc003oqh.2	+	1	118_120	c.31_33delCTG	c.(31-33)CTGdel	p.L15del	NCR2_uc003oqi.2_In_Frame_Del_p.L15del|NCR2_uc003oqj.2_In_Frame_Del_p.L15del	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	15					cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCCACTGCTACTGCTGCTGCTGC	0.635													2	4	---	---	---	---					
MYO6	4646	broad.mit.edu	37	6	76599857	76599858	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr6:76599857_76599858insA	uc003pih.1	+	26	3021_3022	c.2742_2743insA	c.(2740-2745)CAGAAAfs	p.Q914fs	MYO6_uc003pig.1_Frame_Shift_Ins_p.Q914fs|MYO6_uc003pii.1_Frame_Shift_Ins_p.Q914fs	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	914_915	Potential.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GTGCATTACAGAAAAAAAAACA	0.381													8	63	---	---	---	---					
MCPH1	79648	broad.mit.edu	37	8	6289099	6289099	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-7601-01A-11D-2086-08	TCGA-HT-7601-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	61c1c39b-845d-4939-8f36-e74df0b879f4	1f027233-400d-4586-91d7-02f137b0a7d9	g.chr8:6289099delA	uc003wqi.2	+	4	381	c.313delA	c.(313-315)AAAfs	p.K105fs	MCPH1_uc003wqh.2_Frame_Shift_Del_p.K105fs|MCPH1_uc011kwl.1_Frame_Shift_Del_p.K105fs	NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin	105						microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		AAGCCTAATTAAAAAAAAAGT	0.274													8	114	---	---	---	---					
