Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FGR	2268	broad.mit.edu	37	1	27943402	27943402	+	Silent	SNP	G	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr1:27943402G>A	uc001boj.2	-	5	794	c.648C>T	c.(646-648)TTC>TTT	p.F216F	FGR_uc001boi.2_5'Flank|FGR_uc001bok.2_Silent_p.F216F|FGR_uc001bol.2_Silent_p.F216F|FGR_uc001bom.2_Silent_p.F216F	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	216	SH2.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GCACCGAGTTGAACTGAACCC	0.388													47	101					0	0	0.139131	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960425	33960425	+	Silent	SNP	T	G	G			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr1:33960425T>G	uc001bxj.3	+	8	2648	c.2481T>G	c.(2479-2481)CCT>CCG	p.P827P	ZSCAN20_uc009vui.2_Silent_p.P826P	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	827					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GTAGTGAGCCTGGGGGAAACT	0.448													77	112					0	0	0.139131	0	0
LRRC8D	55144	broad.mit.edu	37	1	90400076	90400076	+	Silent	SNP	C	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr1:90400076C>T	uc001dnm.2	+	3	1874	c.1449C>T	c.(1447-1449)CCC>CCT	p.P483P	LRRC8D_uc001dnn.2_Silent_p.P483P	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	483						integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		CGGGGGTGCCCGATGCTGTCT	0.468													13	28					0	0	0.119110	0	0
CFHR5	81494	broad.mit.edu	37	1	196953247	196953247	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr1:196953247C>T	uc001gts.3	+	3	538	c.410C>T	c.(409-411)CCT>CTT	p.P137L		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	137	Sushi 2.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TGGTCCACTCCTCCCATATGC	0.333													15	31					0	0	0.055883	0	0
ASPM	259266	broad.mit.edu	37	1	197091601	197091601	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr1:197091601G>A	uc001gtu.2	-	14	3772	c.3515C>T	c.(3514-3516)ACG>ATG	p.T1172M	ASPM_uc001gtv.2_Missense_Mutation_p.T1172M|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1172	CH 2.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ACCAGTTTGCGTACATTCCAC	0.413													9	19					0	0	0.069234	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430773	37430773	+	Silent	SNP	G	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr10:37430773G>A	uc001iza.1	+	7	879	c.780G>A	c.(778-780)ACG>ACA	p.T260T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	316						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CACCTGACACGGCTGAAAGCT	0.493													3	43					0	0	0.115264	0	0
ANK3	288	broad.mit.edu	37	10	61958113	61958113	+	Silent	SNP	T	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr10:61958113T>C	uc001jky.2	-	14	1866	c.1674A>G	c.(1672-1674)TTA>TTG	p.L558L	ANK3_uc010qih.1_Silent_p.L541L|ANK3_uc001jkz.3_Silent_p.L552L|ANK3_uc001jlb.1_Silent_p.L87L|ANK3_uc001jlc.1_Silent_p.L219L	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	558	ANK 15.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTGTTATAGATAAAGACGCTC	0.498													11	15					0	0	0.119110	0	0
OR2AG2	338755	broad.mit.edu	37	11	6789589	6789589	+	Silent	SNP	G	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr11:6789589G>A	uc001meq.1	-	1	600	c.600C>T	c.(598-600)TAC>TAT	p.Y200Y		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	200	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CACCTGTCACGTATATTATAA	0.493													10	15					0	0	0.069234	0	0
SIPA1	6494	broad.mit.edu	37	11	65408733	65408733	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr11:65408733G>A	uc001ofb.2	+	2	508	c.341G>A	c.(340-342)CGA>CAA	p.R114Q	SIPA1_uc010rom.1_Missense_Mutation_p.R114Q|SIPA1_uc001ofd.2_Missense_Mutation_p.R114Q	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	114					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						CTTGAGCCTCGATGGTTTGCC	0.632													52	75					0	0	0.139131	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19489486	19489486	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr12:19489486A>C	uc001reb.2	+	16	2263	c.2177A>C	c.(2176-2178)GAA>GCA	p.E726A	PLEKHA5_uc010sie.1_Missense_Mutation_p.E829A|PLEKHA5_uc001rea.2_Missense_Mutation_p.E784A|PLEKHA5_uc009zin.2_Missense_Mutation_p.E484A|PLEKHA5_uc010sif.1_Missense_Mutation_p.E657A|PLEKHA5_uc010sig.1_Missense_Mutation_p.E645A|PLEKHA5_uc010sih.1_Missense_Mutation_p.E618A|PLEKHA5_uc001rec.1_Missense_Mutation_p.E472A|PLEKHA5_uc009zio.2_Missense_Mutation_p.E48A	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	726							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GATAAGTTAGAATACGATGTA	0.348													20	28					0	0	0.099896	0	0
KCNJ8	3764	broad.mit.edu	37	12	21926252	21926252	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr12:21926252T>C	uc001rff.2	-	2	637	c.299A>G	c.(298-300)GAC>GGC	p.D100G		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	100	Extracellular (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	AGCATAGATGTCCCCATGGGC	0.507											OREG0021704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	34					0	0	0.059317	0	0
P704P	641455	broad.mit.edu	37	14	20020124	20020124	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr14:20020124G>C	uc001vwc.3	-	1	149	c.97C>G	c.(97-99)CCC>GCC	p.P33A	P704P_uc001vwb.3_RNA	NM_001145442	NP_001138914	A6NI47	POTEM_HUMAN	prostate-specific P704P	33											0						CTGCACCAGGGGAAGCAGTGG	0.587													4	107					0	0	0.009096	0	0
LRRK1	79705	broad.mit.edu	37	15	101588788	101588788	+	Silent	SNP	A	G	G			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr15:101588788A>G	uc002bwr.2	+	22	3544	c.3225A>G	c.(3223-3225)ACA>ACG	p.T1075T	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_Intron	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1075					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GCTGTAGCACATTCAGAGTGA	0.448													45	28					0	0	0.139131	0	0
Unknown	0	broad.mit.edu	37	16	90161578	90161578	+	Silent	SNP	G	A	A	rs13337896	by1000genomes	TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr16:90161578G>A	uc002fqp.2	+	3	931	c.453G>A	c.(451-453)ACG>ACA	p.T151T	uc002fqq.2_Silent_p.T168T					Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.																		GCCAAGGGACGCTACACCGAA	0.587													4	54					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	0					0	0	0.038147	0	0
GAS2L2	246176	broad.mit.edu	37	17	34079638	34079638	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr17:34079638C>T	uc002hjv.1	-	1	260	c.232G>A	c.(232-234)GCC>ACC	p.A78T		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	78	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCCAGGAAGGCCAGGGCAGCG	0.652													21	30					0	0	0.076483	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274343	39274343	+	Silent	SNP	A	G	G			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr17:39274343A>G	uc002hvz.2	-	1	264	c.225T>C	c.(223-225)TGT>TGC	p.C75C		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	75	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].|11.		Missing (in allele KAP4.14).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCTGGGGCGACAGCAGCTGG	0.557													4	129					0	0	0.009096	0	0
HELZ	9931	broad.mit.edu	37	17	65174991	65174991	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr17:65174991C>T	uc010wqk.1	-	13	1401	c.1214G>A	c.(1213-1215)CGT>CAT	p.R405H	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.R405H	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGAATCCCAACGTTTAGCTGT	0.348													14	24					0	0	0.146539	0	0
Unknown	0	broad.mit.edu	37	18	109407	109407	+	RNA	SNP	T	G	G			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr18:109407T>G	uc002kke.2	+	1		c.343T>G								Homo sapiens Rho-associated, coiled-coil containing protein kinase 1, mRNA (cDNA clone IMAGE:5269982), complete cds.																		ttctctgtgctctgcctacag	0													2	2					0	0	0.009096	0	0
SMARCA4	6597	broad.mit.edu	37	19	11132434	11132434	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr19:11132434C>A	uc002mqf.3	+	19	2934	c.2650C>A	c.(2650-2652)CAC>AAC	p.H884N	SMARCA4_uc010dxp.2_Missense_Mutation_p.H884N|SMARCA4_uc010dxo.2_Missense_Mutation_p.H884N|SMARCA4_uc002mqg.1_Missense_Mutation_p.H884N|SMARCA4_uc010dxq.2_Missense_Mutation_p.H884N|SMARCA4_uc010dxr.2_Missense_Mutation_p.H884N|SMARCA4_uc002mqj.3_Missense_Mutation_p.H884N|SMARCA4_uc010dxs.2_Missense_Mutation_p.H884N|SMARCA4_uc010dxt.1_Missense_Mutation_p.H104N|SMARCA4_uc002mqh.3_Missense_Mutation_p.H7N|SMARCA4_uc002mqi.1_Missense_Mutation_p.H87N	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	884	Helicase ATP-binding.|DEGH box.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GGACGAAGGTCACCGCATGAA	0.622			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				13	16					6.72482e-11	7.47203e-11	0.132662	1	0
ZNF799	90576	broad.mit.edu	37	19	12501446	12501446	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr19:12501446T>C	uc010dyt.2	-	4	1916	c.1766A>G	c.(1765-1767)GAA>GGA	p.E589G	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	589	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TTCCTTACATTCATACGGGTT	0.413													3	27					0	0	0.115264	0	0
EPS15L1	58513	broad.mit.edu	37	19	16487940	16487940	+	Silent	SNP	C	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr19:16487940C>T	uc002ndz.1	-	22	2379	c.2373G>A	c.(2371-2373)CCG>CCA	p.P791P	EPS15L1_uc002ndx.2_Silent_p.P791P|EPS15L1_uc002ndy.2_Intron|EPS15L1_uc010xpe.1_Intron|EPS15L1_uc010xpf.1_Silent_p.P694P|EPS15L1_uc002nea.1_Intron|EPS15L1_uc010eah.1_Intron	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	791	Pro-rich.|15 X 3 AA repeats of D-P-F.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						GACCGCTGGGCGGTTTAGGCC	0.612											OREG0025332	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	19					0	0	0.119110	0	0
CCDC150	284992	broad.mit.edu	37	2	197585312	197585312	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr2:197585312C>A	uc002utp.1	+	20	2314	c.2179C>A	c.(2179-2181)CAG>AAG	p.Q727K	CCDC150_uc010zgs.1_Missense_Mutation_p.Q374K|CCDC150_uc010zgt.1_Missense_Mutation_p.Q144K|CCDC150_uc002utq.1_Missense_Mutation_p.Q42K|CCDC150_uc002utr.1_Missense_Mutation_p.Q42K	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	727	Potential.										0						TCTCAATCAACAGAGGGTGCA	0.448													8	31					5.18039e-06	5.39624e-06	0.038147	1	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								27	39					0	0	0.050027	0	0
VIL1	7429	broad.mit.edu	37	2	219295519	219295519	+	Silent	SNP	C	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr2:219295519C>T	uc002via.2	+	10	1085	c.1020C>T	c.(1018-1020)GCC>GCT	p.A340A	VIL1_uc010zke.1_Silent_p.A29A|VIL1_uc002vib.2_Silent_p.A340A|VIL1_uc002vic.1_Silent_p.A340A	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	340	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGAGTCGGCCGTCTTTCAGC	0.597													13	34					0	0	0.038395	0	0
SLC25A1	6576	broad.mit.edu	37	22	19164192	19164192	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr22:19164192T>G	uc002zoz.2	-	7	761	c.646A>C	c.(646-648)AAG>CAG	p.K216Q	SLC25A1_uc002zoy.2_Missense_Mutation_p.K113Q|SLC25A1_uc002zpa.2_Missense_Mutation_p.K164Q	NM_005984	NP_005975	P53007	TXTP_HUMAN	solute carrier family 25 (mitochondrial carrier;	216					gluconeogenesis|long-chain fatty-acyl-CoA biosynthetic process|mitochondrial citrate transport|triglyceride biosynthetic process	integral to membrane|mitochondrial inner membrane	citrate transmembrane transporter activity|protein binding				0	Colorectal(54;0.0993)	all_lung(157;9.94e-09)		Lung(27;0.124)		TTCATGGGCTTGTTGGGGTTG	0.592													11	21					0	0	0.093190	0	0
UGT2B10	7365	broad.mit.edu	37	4	69870669	69870669	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr4:69870669C>A	uc011cao.1	-	9	1517	c.1381G>T	c.(1381-1383)GCT>TCT	p.A461S	UGT2B10_uc011can.1_Missense_Mutation_p.A377S			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	498	Helical; (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GCCACACAGGCCAGCAGGAAC	0.448													8	111					0.00448238	0.00457386	0.047766	1	0
PCDH18	54510	broad.mit.edu	37	4	138452008	138452008	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr4:138452008T>C	uc003ihe.3	-	1	1622	c.1235A>G	c.(1234-1236)GAA>GGA	p.E412G	PCDH18_uc003ihf.3_Missense_Mutation_p.E405G|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.E192G|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	412	Cadherin 4.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					ATAATTGTTTTCATATGTCTT	0.403													3	23					0	0	0.009096	0	0
PCDHA11	56138	broad.mit.edu	37	5	140249016	140249016	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr5:140249016G>A	uc003lia.2	+	1	1186	c.328G>A	c.(328-330)GTG>ATG	p.V110M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.V110M	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	110	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGGTGATCGTGGACAGGCC	0.552													122	134					0	0	0.139131	0	0
DUSP22	56940	broad.mit.edu	37	6	348774	348774	+	Silent	SNP	G	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr6:348774G>T	uc003msx.2	+	7	880	c.441G>T	c.(439-441)CGG>CGT	p.R147R	DUSP22_uc011dhn.1_Silent_p.R147R|DUSP22_uc003msy.1_Silent_p.R104R	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	147					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		TCCAGTATCGGCAGTGGCTGA	0.522													18	75					2.98393e-07	3.1744e-07	0.076483	1	0
TNXB	7148	broad.mit.edu	37	6	31978785	31978785	+	Missense_Mutation	SNP	C	T	T	rs117233407	by1000genomes	TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr6:31978785C>T	uc011dpc.1	-	4	1613	c.704G>A	c.(703-705)CGG>CAG	p.R235Q	STK19_uc003nza.2_5'Flank|STK19_uc003nzb.2_5'Flank	NM_032470	NP_115859	P22105	TENX_HUMAN	tenascin XB isoform 2	3851	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGTCCGGGCCCGGCCGTCCAC	0.637													5	65					0	0	0.047766	0	0
FIGNL1	63979	broad.mit.edu	37	7	50513534	50513534	+	Silent	SNP	T	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr7:50513534T>C	uc003tpc.2	-	4	1829	c.1452A>G	c.(1450-1452)GCA>GCG	p.A484A	FIGNL1_uc003tpb.2_Silent_p.A373A|FIGNL1_uc003tpd.2_Silent_p.A484A|FIGNL1_uc003tpe.2_Silent_p.A484A|FIGNL1_uc010kyy.2_Silent_p.A484A	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	484					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				CAGCAAACAATGCACGGACCA	0.443													43	59					0	0	0.139131	0	0
SEMA3C	10512	broad.mit.edu	37	7	80374454	80374454	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr7:80374454G>A	uc003uhj.2	-	18	2574	c.2012C>T	c.(2011-2013)ACG>ATG	p.T671M	SEMA3C_uc011kgw.1_Missense_Mutation_p.T689M	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	671					immune response|response to drug	membrane	receptor activity			ovary(1)	1						CCATTTGTCCGTCACAACAGC	0.478													19	31					0	0	0.076483	0	0
JPH1	56704	broad.mit.edu	37	8	75171665	75171665	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr8:75171665C>T	uc003yae.2	-	3	1253	c.1213G>A	c.(1213-1215)GCG>ACG	p.A405T	JPH1_uc003yaf.2_Missense_Mutation_p.A405T|JPH1_uc003yag.1_Missense_Mutation_p.A269T	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	405	Ala-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			ACAGCTCTCGCGATGTCGCAC	0.607													18	22					0	0	0.043863	0	0
NUDCD1	84955	broad.mit.edu	37	8	110287672	110287672	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr8:110287672A>C	uc003ynb.3	-	7	1193	c.1082T>G	c.(1081-1083)GTA>GGA	p.V361G	NUDCD1_uc003yna.2_Missense_Mutation_p.V332G|NUDCD1_uc010mcl.2_Missense_Mutation_p.V274G|NUDCD1_uc010mcm.1_Missense_Mutation_p.V274G	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	361	CS.									ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			ATCTCCAATTACTAGCTCTGG	0.383													10	21					0	0	0.080935	0	0
EPPK1	83481	broad.mit.edu	37	8	144940576	144940576	+	Silent	SNP	C	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr8:144940576C>T	uc003zaa.1	-	2	14869	c.14856G>A	c.(14854-14856)TCG>TCA	p.S4952S		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4952	Plectin 62.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTCCTCCACCGACAGCCTCA	0.736													3	64					0	0	0.014758	0	0
ZFP37	7539	broad.mit.edu	37	9	115811700	115811700	+	Silent	SNP	T	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr9:115811700T>C	uc004bgm.1	-	3	319	c.291A>G	c.(289-291)AGA>AGG	p.R97R	ZFP37_uc011lwz.1_Silent_p.R112R|ZFP37_uc011lxa.1_Silent_p.R98R	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	97	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CTTGACTGGGTCTTTTCCCCT	0.403													22	6					0	0	0.099896	0	0
DDX31	64794	broad.mit.edu	37	9	135522404	135522404	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr9:135522404T>C	uc004cbq.1	-	12	1476	c.1324A>G	c.(1324-1326)AGT>GGT	p.S442G	DDX31_uc010mzu.1_Missense_Mutation_p.S442G|DDX31_uc004cbr.1_Missense_Mutation_p.S442G	NM_022779	NP_073616	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	442	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		ACAGAAATACTGACTGGATCA	0.493													31	44					0	0	0.080422	0	0
GSPT2	23708	broad.mit.edu	37	X	51488448	51488448	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chrX:51488448G>A	uc004dpl.2	+	1	1952	c.1726G>A	c.(1726-1728)GTG>ATG	p.V576M		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	576					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					ACCCCGCTTCGTGAAACAAGA	0.418													20	15					0	0	0.091800	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912924	77912924	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chrX:77912924G>T	uc004edc.1	-	2	1290	c.994C>A	c.(994-996)CTC>ATC	p.L332I		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	332							nucleic acid binding|zinc ion binding			ovary(1)	1						CCTTGGCAGAGTTGATGGATG	0.463													9	18					2.74318e-10	2.98172e-10	0.058154	1	0
ODZ1	10178	broad.mit.edu	37	X	123525932	123525932	+	Silent	SNP	C	T	T			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chrX:123525932C>T	uc004euj.2	-	27	5701	c.5637G>A	c.(5635-5637)GGG>GGA	p.G1879G	ODZ1_uc011muj.1_Silent_p.G1885G|ODZ1_uc010nqy.2_Silent_p.G1886G	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1879	Extracellular (Potential).|YD 7.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCCAAATTTTCCCATCAGCCC	0.378													9	7					0	0	0.119110	0	0
NES	10763	broad.mit.edu	37	1	156642804	156642804	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr1:156642804delG	uc001fpq.2	-	4	1309	c.1176delC	c.(1174-1176)CCCfs	p.P392fs		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	392	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTGAGGTGTGGGGGGGATGG	0.597													7	293	---	---	---	---					
MED12L	116931	broad.mit.edu	37	3	151148114	151148116	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr3:151148114_151148116delCAG	uc003eyp.2	+	42	6369_6371	c.6331_6333delCAG	c.(6331-6333)CAGdel	p.Q2115del	MED12L_uc011bnz.1_In_Frame_Del_p.Q1779del	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	2115	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAGCAGACCCAGCAGCAGCAGC	0.527													8	89	---	---	---	---					
MDFI	4188	broad.mit.edu	37	6	41621169	41621171	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr6:41621169_41621171delCTG	uc003oqp.3	+	6	926_928	c.597_599delCTG	c.(595-600)CTCTGC>CTC	p.C204del	MDFI_uc003oqq.3_In_Frame_Del_p.C204del|MDFI_uc010jxn.2_In_Frame_Del_p.C204del	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	204	Cys-rich.				cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			ACTCGTGCCTCTGCTGCTGCTGC	0.655													13	188	---	---	---	---					
SEC63	11231	broad.mit.edu	37	6	108214774	108214774	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chr6:108214774delT	uc003psc.3	-	16	1855	c.1586delA	c.(1585-1587)AAGfs	p.K529fs	SEC63_uc003psb.3_Frame_Shift_Del_p.K389fs	NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	529	SEC63 1.|Cytoplasmic (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TAAAGGTTTCTTTTTTTTTGA	0.368													2	4	---	---	---	---					
SHROOM4	57477	broad.mit.edu	37	X	50350672	50350674	+	In_Frame_Del	DEL	TCT	-	-	rs3747282	byFrequency	TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chrX:50350672_50350674delTCT	uc004dpe.2	-	6	3494_3496	c.3468_3470delAGA	c.(3466-3471)GAAGAG>GAG	p.1156_1157EE>E	SHROOM4_uc004dpd.3_RNA	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1156_1157	Glu-rich.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					TGGCAGctcctcttcctcctcct	0.261													3	6	---	---	---	---					
RBM41	55285	broad.mit.edu	37	X	106331986	106331986	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-7606-01A-11D-2086-08	TCGA-HT-7606-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	9734311d-3183-459b-8200-7104fba3bf64	7c7214f7-036a-4ac9-9883-1a93d9eb6f10	g.chrX:106331986delC	uc004emz.2	-	5	638	c.607delG	c.(607-609)GAAfs	p.E203fs	RBM41_uc004emy.1_Frame_Shift_Del_p.E203fs	NM_018301	NP_060771	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	203							nucleotide binding|RNA binding			ovary(1)	1						TGAAACTCTTCAAGACGTTTT	0.428													15	27	---	---	---	---					
