Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF687	57592	broad.mit.edu	37	1	151258917	151258917	+	Silent	SNP	A	G	G			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr1:151258917A>G	uc001exq.2	+	2	248	c.150A>G	c.(148-150)GAA>GAG	p.E50E	ZNF687_uc001exp.1_Silent_p.E59E|ZNF687_uc009wmo.2_Silent_p.E50E|ZNF687_uc009wmp.2_Silent_p.E50E	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TAGGAAGTGAATCTGAAGACA	0.572000													32	53					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156628820	156628820	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr1:156628820C>A	uc001fpp.2	+	14	2966	c.2630C>A	c.(2629-2631)GCC>GAC	p.A877D		NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	877					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTTCCCCAGGCCCGAGCTCTG	0.627000													2	6					0.0016	0.0016	1	1	0
RNPEP	6051	broad.mit.edu	37	1	201966606	201966606	+	Silent	SNP	C	T	T			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr1:201966606C>T	uc001gxd.2	+	5	1043	c.1014C>T	c.(1012-1014)AAC>AAT	p.N338N	RNPEP_uc001gxe.2_Silent_p.N39N|RNPEP_uc001gxf.2_Silent_p.N207N	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase	338					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		TGGTCACCAACGCCAACTGGG	0.547000													6	94					0	0	1	0	0
MLL2	8085	broad.mit.edu	37	12	49416133	49416133	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr12:49416133G>A	uc001rta.3	-	52	16342	c.16342C>T	c.(16342-16344)CGA>TGA	p.R5448*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5448	SET.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TAGATGCCTCGATTCTAGAAA	0.517000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			9	11					0	0	1	0	0
NAB2	4665	broad.mit.edu	37	12	57485457	57485457	+	Silent	SNP	T	C	C			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr12:57485457T>C	uc001smz.2	+	2	1011	c.633T>C	c.(631-633)CCT>CCC	p.P211P		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	211					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCTCCCCCCCTGCAGGGGGAG	0.711000													7	43					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106820987	106820987	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr12:106820987C>T	uc001tlp.2	+	13	1336	c.1114C>T	c.(1114-1116)CTT>TTT	p.L372F	POLR3B_uc001tlq.2_Missense_Mutation_p.L314F	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	372					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTTATCTCTTCTTTTTGAAGA	0.274000													6	16					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32911765	32911765	+	Missense_Mutation	SNP	A	C	C	rs80359382		TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr13:32911765A>C	uc001uub.1	+	11	3500	c.3273A>C	c.(3271-3273)TTA>TTC	p.L1091F		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1091					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CTCAGATGTTATTTTCCAAGC	0.333000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			27	59					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20692083	20692083	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr14:20692083G>A	uc010tlc.1	+	1	215	c.215G>A	c.(214-216)CGG>CAG	p.R72Q		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	72	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TTGGACAGGCGGCTCCACACA	0.478000													22	86					0	0	1	0	0
C14orf118	55668	broad.mit.edu	37	14	76668100	76668100	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr14:76668100G>A	uc001xsh.2	+	10	1441	c.1355G>A	c.(1354-1356)TGG>TAG	p.W452*	C14orf118_uc001xsi.2_Nonsense_Mutation_p.W447*|C14orf118_uc001xsl.2_RNA|C14orf118_uc001xsn.1_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	452										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		AGCTCTGAGTGGTTGGTGAGG	0.488000													14	56					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105174321	105174321	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr14:105174321C>T	uc001ypb.2	+	8	1860	c.1717C>T	c.(1717-1719)CCA>TCA	p.P573S	INF2_uc010tyi.1_Missense_Mutation_p.P573S|INF2_uc001ypc.2_Missense_Mutation_p.P573S|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	573	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		GCAGAAGCTGCCATCCAACGT	0.657000													19	38					0	0	1	0	0
IDH2	3418	broad.mit.edu	37	15	90631838	90631838	+	Missense_Mutation	SNP	C	T	T	rs121913503		TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr15:90631838C>T	uc002box.2	-	4	601	c.515G>A	c.(514-516)AGG>AAG	p.R172K	IDH2_uc010uqb.1_Missense_Mutation_p.R120K|IDH2_uc010uqc.1_Missense_Mutation_p.R42K|IDH2_uc010bnu.2_Intron	NM_002168	NP_002159	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+),	172		Substrate (By similarity).			2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding	p.R172K(170)|p.R172M(21)|p.R172S(12)|p.R172W(7)|p.R172?(7)|p.R172G(2)		haematopoietic_and_lymphoid_tissue(621)|central_nervous_system(80)|bone(7)|skin(3)	711	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			ATGGGCGTGCCTGCCAATGGT	0.632000			M		GBM								22	53					0	0	1	0	0
GLIS2	84662	broad.mit.edu	37	16	4386949	4386949	+	Silent	SNP	A	C	C			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr16:4386949A>C	uc002cwc.1	+	6	1056	c.999A>C	c.(997-999)CCA>CCC	p.P333P		NM_032575	NP_115964	Q9BZE0	GLIS2_HUMAN	GLIS family zinc finger 2	333					cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development	cytoplasm|nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|transcription regulatory region DNA binding|zinc ion binding				0						AGCTGCGCCCACCCCCCAAGC	0.677000													5	12					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66914237	66914237	+	Silent	SNP	G	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr17:66914237G>A	uc002jhp.2	-	14	2057	c.1878C>T	c.(1876-1878)CGC>CGT	p.R626R	ABCA8_uc002jhq.2_Silent_p.R666R|ABCA8_uc010wqq.1_Silent_p.R666R|ABCA8_uc010wqr.1_Silent_p.R605R|ABCA8_uc002jhr.2_Silent_p.R666R	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	626	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					AGAGGATCACGCGGTCTGTTT	0.453000													6	76					0	0	1	0	0
CD300A	11314	broad.mit.edu	37	17	72469878	72469878	+	Missense_Mutation	SNP	G	A	A	rs148191018	byFrequency	TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr17:72469878G>A	uc002jkv.2	+	2	565	c.244G>A	c.(244-246)GCA>ACA	p.A82T	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	82	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						GGACAGTCCTGCAAACCTCAG	0.532000													5	84					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791757	42791757	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr19:42791757C>T	uc002otf.1	+	5	683	c.643C>T	c.(643-645)CGG>TGG	p.R215W		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	215	HMG box.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CAAGCGGCACCGGGCCCTGGT	0.612000			T	DUX4	soft tissue sarcoma								18	40					0	0	1	0	0
PNKP	11284	broad.mit.edu	37	19	50370414	50370414	+	Silent	SNP	A	G	G			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr19:50370414A>G	uc002pqh.2	-	1	100	c.48T>C	c.(46-48)CCT>CCC	p.P16P	PNKP_uc002pqg.2_5'Flank|PNKP_uc002pqi.2_5'UTR|PNKP_uc002pqj.2_Silent_p.P16P|PNKP_uc010enm.2_Silent_p.P16P|PNKP_uc002pqk.2_Silent_p.P16P	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	16					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		GCGCTCCCCCAGGGGGGCTCT	0.721000								Other_BER_factors					6	12					0	0	1	0	0
OXER1	165140	broad.mit.edu	37	2	42990225	42990225	+	Missense_Mutation	SNP	C	G	G	rs143944527	byFrequency	TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr2:42990225C>G	uc002rss.2	-	1	1177	c.1095G>C	c.(1093-1095)CAG>CAC	p.Q365H		NM_148962	NP_683765	Q8TDS5	OXER1_HUMAN	G-protein coupled receptor TG1019	365	Cytoplasmic (Potential).				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)	1						AGGCCCGGCTCTGGTGGAGGA	0.652000													4	49					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17462592	17462592	+	Silent	SNP	G	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr20:17462592G>A	uc002wpm.2	+	12	2114	c.1794G>A	c.(1792-1794)CCG>CCA	p.P598P	PCSK2_uc002wpl.2_Silent_p.P579P|PCSK2_uc010zrm.1_Silent_p.P563P|PCSK2_uc002wpn.2_Silent_p.P252P	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	598					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGAGTGCCCCGTACATCGACC	0.612000													3	28					0	0	1	0	0
C21orf99	149992	broad.mit.edu	37	21	14439208	14439208	+	RNA	SNP	A	G	G			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr21:14439208A>G	uc002yja.3	+	10		c.2726A>G				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AAGAGAAGAAATGCCAATATA	0.299000													5	41					0	0	1	0	0
IL2RB	3560	broad.mit.edu	37	22	37524372	37524372	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr22:37524372G>A	uc003aqv.1	-	10	1551	c.1420C>T	c.(1420-1422)CCT>TCT	p.P474S		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	474	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GGGGTGGGAGGCCCCAGGGGC	0.677000													22	43					0	0	1	0	0
POC5	134359	broad.mit.edu	37	5	74981103	74981103	+	Missense_Mutation	SNP	C	T	T	rs34678567	by1000genomes	TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr5:74981103C>T	uc003keh.3	-	10	1533	c.1336G>A	c.(1336-1338)GCA>ACA	p.A446T	POC5_uc010izu.2_Missense_Mutation_p.A329T|POC5_uc003keg.3_Missense_Mutation_p.A421T	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	446					cell cycle	centriole				lung(1)	1						ACAGAAGATGCGGAAGCAGCC	0.552000													4	42					0	0	1	0	0
SPDYE7P	441251	broad.mit.edu	37	7	72338030	72338030	+	RNA	SNP	G	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr7:72338030G>A	uc010lal.1	-	1		c.1626C>T				NR_003666				Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.												0						acttgaacccgggaggcatcg	0.005000													2	6					0	0	1	0	0
SYAP1	94056	broad.mit.edu	37	X	16774794	16774794	+	Silent	SNP	C	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chrX:16774794C>A	uc004cxp.2	+	7	826	c.733C>A	c.(733-735)CGG>AGG	p.R245R	SYAP1_uc004cxo.2_Silent_p.R245R|SYAP1_uc011miv.1_Silent_p.R211R	NM_032796	NP_116185	Q96A49	SYAP1_HUMAN	SYAP1 protein	245										skin(1)	1	Hepatocellular(33;0.0997)					AGAGGCAGTACGGCCCAAAAC	0.343000													9	36					7.48243e-07	7.66949e-07	1	1	0
MORF4L2	9643	broad.mit.edu	37	X	102931856	102931856	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chrX:102931856T>C	uc004ekw.2	-	4	1332	c.100A>G	c.(100-102)ATG>GTG	p.M34V	MORF4L2_uc004ela.2_Missense_Mutation_p.M34V|MORF4L2_uc004ekx.2_Missense_Mutation_p.M34V|MORF4L2_uc004elb.2_Missense_Mutation_p.M34V|MORF4L2_uc004eky.2_Missense_Mutation_p.M34V|MORF4L2_uc010nos.2_Missense_Mutation_p.M34V|MORF4L2_uc004ekz.2_Missense_Mutation_p.M34V|MORF4L2_uc011mry.1_Missense_Mutation_p.M34V|MORF4L2_uc011mrz.1_Missense_Mutation_p.M34V|MORF4L2_uc004elc.2_Missense_Mutation_p.M34V|MORF4L2_uc004elf.2_Missense_Mutation_p.M34V|MORF4L2_uc004ele.2_Missense_Mutation_p.M34V|MORF4L2_uc011msa.1_Missense_Mutation_p.M34V|MORF4L2_uc011msb.1_Missense_Mutation_p.M34V|MORF4L2_uc011msc.1_Missense_Mutation_p.M34V|MORF4L2_uc011msd.1_Missense_Mutation_p.M34V|MORF4L2_uc004eld.2_Missense_Mutation_p.M34V	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	34					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						GCCCCTCTCATTTTACTTCTC	0.488000													52	61					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148049222	148049222	+	Silent	SNP	G	T	T			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chrX:148049222G>T	uc004fcp.2	+	15	3746	c.3267G>T	c.(3265-3267)CTG>CTT	p.L1089L	AFF2_uc004fcq.2_Silent_p.L1079L|AFF2_uc004fcr.2_Silent_p.L1050L|AFF2_uc011mxb.1_Silent_p.L1054L|AFF2_uc004fcs.2_Silent_p.L1054L|AFF2_uc011mxc.1_Silent_p.L730L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1089					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CTGATGCACTGGTAAGTTTCC	0.348000													20	45					2.37509e-13	2.49689e-13	1	1	0
MMP12	4321	broad.mit.edu	37	11	102738793	102738794	+	Splice_Site	INS	-	T	T	rs139197361	by1000genomes	TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr11:102738793_102738794insT	uc001phk.2	-	5	675	c.630_splice	c.e5+1	p.T210_splice		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGAGGAACAAGTGGTGCCTAAG	0.416													4	7	---	---	---	---					
SAMD4A	23034	broad.mit.edu	37	14	55236839	55236840	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr14:55236839_55236840insA	uc001xbb.2	+	8	1612_1613	c.1611_1612insA	c.(1609-1614)CAGAAAfs	p.Q537fs	SAMD4A_uc001xbc.2_Frame_Shift_Ins_p.Q449fs|SAMD4A_uc001xbg.2_Frame_Shift_Ins_p.Q129fs	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	538_539					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						CAGAGACACAGAAAAAAAGATT	0.416													26	99	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	G	G	rs2981599		TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr16:3119304_3119305insG	uc002cto.2	+	6	864_865	c.653_654insG	c.(652-654)GACfs	p.D218fs	IL32_uc002ctk.2_Frame_Shift_Ins_p.D115fs|IL32_uc010uwp.1_Frame_Shift_Ins_p.D152fs|IL32_uc010btb.2_Frame_Shift_Ins_p.D162fs|IL32_uc002ctl.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctm.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctn.2_Frame_Shift_Ins_p.D172fs|IL32_uc002cts.3_Frame_Shift_Ins_p.D172fs|IL32_uc002ctp.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctq.2_Frame_Shift_Ins_p.D218fs|IL32_uc002ctr.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctt.2_Frame_Shift_Ins_p.D172fs|IL32_uc010uwr.1_Frame_Shift_Ins_p.D132fs|IL32_uc002ctu.2_Frame_Shift_Ins_p.D163fs	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CCACGGGGGGACAAGGAGGAGC	0.574													13	242	---	---	---	---					
FBXL19	54620	broad.mit.edu	37	16	30939204	30939204	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chr16:30939204delC	uc002eab.2	+	5	765	c.607delC	c.(607-609)CCCfs	p.P203fs	FBXL19_uc002dzz.1_5'UTR|FBXL19_uc002eaa.1_Frame_Shift_Del_p.P145fs	NM_001099784	NP_001093254	Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	203	Pro-rich.						DNA binding|zinc ion binding			ovary(2)|lung(1)|breast(1)	4						GCCTGCCGGGCCCCCCCCGGA	0.711													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	M	16189	16190	+	RNA	INS	-	C	C			TCGA-HT-7681-01A-11D-2395-08	TCGA-HT-7681-10C-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	378982db-a5b2-405d-be34-30b870c8d215	16689ce9-1a6c-4702-91eb-68955024ac3e	g.chrM:16189_16190insC	uc004coz.1	+	2		c.193_194insC								Homo sapiens isolate ON mitochondrial control region, partial sequence.																		TCAAACCCCCCCCCCCCATGCT	0.455													6	2	---	---	---	---					
