Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF10	100132406	broad.mit.edu	37	1	145327544	145327544	+	Silent	SNP	A	C	C			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr1:145327544A>C	uc001end.3	+	34	4361	c.4326A>C	c.(4324-4326)TCA>TCC	p.S1442S	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oym.1_Intron|NBPF10_uc010oyn.1_Intron|NBPF10_uc010oyo.1_Intron|NBPF10_uc010oyp.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	1367											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TGCAGGACTCACTGAATAGAT	0.473000													2	4					0	0	0.115264	0	0
NR1H3	10062	broad.mit.edu	37	11	47281984	47281984	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr11:47281984A>G	uc009ylm.2	+	4	478	c.257A>G	c.(256-258)AAG>AGG	p.K86R	NR1H3_uc009yll.1_Missense_Mutation_p.K92R|NR1H3_uc010rhk.1_Missense_Mutation_p.K92R|NR1H3_uc001nek.2_Missense_Mutation_p.K41R|NR1H3_uc001nej.2_Missense_Mutation_p.K86R|NR1H3_uc001nel.2_Missense_Mutation_p.K41R|NR1H3_uc001nen.3_Missense_Mutation_p.K86R|NR1H3_uc001nem.2_Missense_Mutation_p.K86R|NR1H3_uc001nep.2_5'UTR	NM_005693	NP_005684	Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	86					apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			ovary(2)|lung(1)	3						AAGCGGAAAAAGGGGCCAGCC	0.567000													3	49					0	0	0.115264	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839036	128839036	+	Silent	SNP	G	A	A			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr11:128839036G>A	uc009zcp.2	-	22	6030	c.6030C>T	c.(6028-6030)CAC>CAT	p.H2010H	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Silent_p.H969H|ARHGAP32_uc001qez.2_Silent_p.H1661H	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	2010	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GGCGCTTGCCGTGTGGTTGGT	0.567000													3	70					0	0	0.150653	0	0
Unknown	0	broad.mit.edu	37	12	92119	92119	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr12:92119T>C	uc010sdi.1	-	2	219	c.191A>G	c.(190-192)CAC>CGC	p.H64R	uc010sdj.1_RNA					SubName: Full=DEAD/H box polypeptide 11 like 11;																		CGCCAGGCAGTGGTGCAGCTG	0.592000													6	25					0	0	0.248553	0	0
TAS2R42	353164	broad.mit.edu	37	12	11339191	11339191	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr12:11339191A>G	uc001qzr.1	-	1	353	c.353T>C	c.(352-354)CTT>CCT	p.L118P	PRB4_uc001qzf.1_Intron	NM_181429	NP_852094	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	118	Helical; Name=4; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			CCAGAGGAAAAGGGAGTGGGG	0.398000													3	48					0	0	0.150653	0	0
AK7	122481	broad.mit.edu	37	14	96944967	96944967	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr14:96944967T>C	uc001yfn.2	+	15	1765	c.1721T>C	c.(1720-1722)TTT>TCT	p.F574S		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	574					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TTCAACTATTTTGATGAACTT	0.478000													36	48					0	0	0.840704	0	0
ZZEF1	23140	broad.mit.edu	37	17	3970464	3970464	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr17:3970464A>G	uc002fxe.2	-	27	4212	c.4148T>C	c.(4147-4149)ATA>ACA	p.I1383T	ZZEF1_uc002fxi.2_5'Flank|ZZEF1_uc002fxj.1_5'UTR	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1383							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TACCATCCATATTCGAATCCC	0.393000													3	42					0	0	0.115264	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	rs28934576	by1000genomes	TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	4					0	0	0.435327	0	0
MYH2	4620	broad.mit.edu	37	17	10429940	10429940	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr17:10429940C>T	uc010coi.2	-	30	4291	c.4163G>A	c.(4162-4164)CGC>CAC	p.R1388H	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1388H|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1388	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R1388H(1)		ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTCCTCTGTGCGCTGGATGGC	0.512000													52	145					0	0	0.870114	0	0
TUBG1	7283	broad.mit.edu	37	17	40767042	40767042	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr17:40767042G>A	uc002ian.2	+	11	1737	c.1339G>A	c.(1339-1341)GGC>AGC	p.G447S		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	447					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		CATCTCCTGGGGCACCCAGGA	0.582000													4	36					0	0	0.184627	0	0
ZNF844	284391	broad.mit.edu	37	19	12187475	12187475	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr19:12187475C>G	uc002mtb.2	+	4	1683	c.1540C>G	c.(1540-1542)CAT>GAT	p.H514D	ZNF844_uc010dym.1_Missense_Mutation_p.H357D	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGCCTTCACATCTGCCTCA	0.408000													4	32					0	0	0.184627	0	0
COBLL1	22837	broad.mit.edu	37	2	165550871	165550871	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr2:165550871C>A	uc010zcw.1	-	15	3470	c.3346G>T	c.(3346-3348)GCA>TCA	p.A1116S	COBLL1_uc002ucp.2_Missense_Mutation_p.A1049S|COBLL1_uc002ucq.2_Missense_Mutation_p.A1011S|COBLL1_uc010zcx.1_Missense_Mutation_p.A1057S|COBLL1_uc002ucn.2_Missense_Mutation_p.A477S|COBLL1_uc002uco.2_Missense_Mutation_p.A780S	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	1087										ovary(2)|pancreas(1)	3						TGGACCAATGCACTGGCACTA	0.473000													4	52					0.00909568	0.00934834	0.150653	1	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								29	48					0	0	0.804634	0	0
PLCH1	23007	broad.mit.edu	37	3	155200712	155200712	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr3:155200712T>C	uc011bok.1	-	23	3404	c.3127A>G	c.(3127-3129)ATT>GTT	p.I1043V	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.I1005V	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1043					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GTAGATACAATGGTGTCCCCT	0.458000													31	57					0	0	0.834066	0	0
ANXA10	11199	broad.mit.edu	37	4	169105805	169105805	+	Silent	SNP	T	C	C			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr4:169105805T>C	uc003irm.2	+	11	1024	c.879T>C	c.(877-879)TAT>TAC	p.Y293Y	ANXA10_uc003irn.2_Silent_p.Y165Y	NM_007193	NP_009124	Q9UJ72	ANX10_HUMAN	annexin A10	293	Annexin 4.						calcium ion binding|calcium-dependent phospholipid binding				0		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		AAGAGCGATATGGAAAATCCC	0.353000													52	78					0	0	0.870114	0	0
PRDM9	56979	broad.mit.edu	37	5	23526872	23526872	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr5:23526872C>T	uc003jgo.2	+	11	1857	c.1675C>T	c.(1675-1677)CGG>TGG	p.R559W		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	559	C2H2-type 3.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGAGTGTGGGCGGGGCTTTAG	0.527000										HNSCC(3;0.000094)			28	72					0	0	0.717897	0	0
HCN1	348980	broad.mit.edu	37	5	45262356	45262356	+	Silent	SNP	G	T	T			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr5:45262356G>T	uc003jok.2	-	8	2365	c.2340C>A	c.(2338-2340)ACC>ACA	p.T780T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	780	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TGACTTCCCGGGTCAGGTTGG	0.592000													19	32					4.35082e-09	4.87819e-09	0.592651	1	0
DHX29	54505	broad.mit.edu	37	5	54577281	54577281	+	Silent	SNP	G	C	C			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr5:54577281G>C	uc003jpx.2	-	12	2148	c.2028C>G	c.(2026-2028)CTC>CTG	p.L676L	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	676	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTGTACAATAGAGTAACCTGG	0.393000													35	54					0	0	0.819951	0	0
UNC5CL	222643	broad.mit.edu	37	6	40996311	40996311	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr6:40996311G>T	uc003opi.2	-	9	1447	c.1358C>A	c.(1357-1359)CCC>CAC	p.P453H		NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	453	Death.|Cytoplasmic (Potential).				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGCCGCTGCGGGGCTGCGCTG	0.672000													27	58					3.67414e-24	4.38526e-24	0.760397	1	0
LAMA2	3908	broad.mit.edu	37	6	129468139	129468139	+	Silent	SNP	G	T	T			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr6:129468139G>T	uc003qbn.2	+	6	960	c.855G>T	c.(853-855)GGG>GGT	p.G285G	LAMA2_uc003qbo.2_Silent_p.G285G	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	285	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CAGTTGGAGGGATGTGCATCT	0.433000													7	170					7.48243e-07	7.91e-07	0.335167	1	0
ADAM28	10863	broad.mit.edu	37	8	24201057	24201057	+	Silent	SNP	A	G	G			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr8:24201057A>G	uc003xdy.2	+	18	2033	c.1950A>G	c.(1948-1950)GGA>GGG	p.G650G	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Silent_p.G337G	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	650	EGF-like.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		GTGAGGAAGGATGGATCCCTC	0.498000													23	47					0	0	0.779181	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110408325	110408325	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr8:110408325T>C	uc003yne.2	+	11	985	c.881T>C	c.(880-882)TTC>TCC	p.F294S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	294	Extracellular (Potential).|IPT/TIG 3.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGTGGGCGTTTCTTTGATCAG	0.403000										HNSCC(38;0.096)			9	13					0	0	0.387290	0	0
EPPK1	83481	broad.mit.edu	37	8	144941387	144941387	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr8:144941387G>T	uc003zaa.1	-	1	6048	c.6035C>A	c.(6034-6036)GCC>GAC	p.A2012D		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2012	Plectin 34.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCCCCCGTGGCCACCTGCAC	0.627000													13	22					3.27435e-08	3.56327e-08	0.457914	1	0
UBAP1	51271	broad.mit.edu	37	9	34250662	34250662	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr9:34250662G>T	uc003ztx.2	+	6	1508	c.1273G>T	c.(1273-1275)GAC>TAC	p.D425Y	UBAP1_uc010mka.1_Missense_Mutation_p.D461Y|UBAP1_uc003zty.2_Missense_Mutation_p.D425Y|UBAP1_uc011loi.1_Missense_Mutation_p.D461Y|UBAP1_uc011loj.1_Missense_Mutation_p.D489Y|KIF24_uc010mkb.2_Intron|UBAP1_uc003ztz.2_Missense_Mutation_p.D425Y	NM_016525	NP_057609	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	425	UBA 1.					cytoplasm					0			LUSC - Lung squamous cell carcinoma(29;0.00272)			TTAGATTCTCGACTATCTCTT	0.468000													19	31					4.35082e-09	4.87819e-09	0.592651	1	0
LOC442421	442421	broad.mit.edu	37	9	66500810	66500810	+	RNA	SNP	G	A	A	rs142815546	by1000genomes	TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr9:66500810G>A	uc004aed.1	+	3		c.903G>A								Homo sapiens similar to prostaglandin E receptor 4, subtype EP4; PGE receptor, EP4 subtype; prostaglandin E2 receptor, mRNA (cDNA clone IMAGE:5288780).												0						ACCTACGGTCGGTTGTGTGCA	0.637000													3	21					0	0	0.115264	0	0
CCNB3	85417	broad.mit.edu	37	X	50055581	50055581	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chrX:50055581T>A	uc004dox.3	+	7	3670	c.3372T>A	c.(3370-3372)AGT>AGA	p.S1124R	CCNB3_uc004doy.2_Missense_Mutation_p.S1124R|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Missense_Mutation_p.S16R	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1124					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GTGATCCAAGTTTCAACCCAA	0.383000													19	117					0	0	0.654019	0	0
ATP2B3	492	broad.mit.edu	37	X	152826160	152826160	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chrX:152826160G>A	uc004fht.1	+	17	2992	c.2866G>A	c.(2866-2868)GGG>AGG	p.G956R	ATP2B3_uc004fhs.1_Missense_Mutation_p.G956R|ATP2B3_uc010nuf.1_5'UTR|ATP2B3_uc004fhu.1_5'Flank	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	956	Extracellular (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CATCGACAGCGGGAGGAATGC	0.552000													3	73					0	0	0.150653	0	0
TRIM33	51592	broad.mit.edu	37	1	114968116	114968118	+	In_Frame_Del	DEL	TGT	-	-			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr1:114968116_114968118delTGT	uc001eew.2	-	9	1732_1734	c.1648_1650delACA	c.(1648-1650)ACAdel	p.T550del	TRIM33_uc010owr.1_In_Frame_Del_p.T140del|TRIM33_uc010ows.1_In_Frame_Del_p.T158del|TRIM33_uc001eex.2_In_Frame_Del_p.T550del	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	550	Poly-Thr.				negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATGCTGTTGTGTTGTTGTTGTT	0.429			T	RET	papillary thyroid								8	463	---	---	---	---					
SCAF1	58506	broad.mit.edu	37	19	50155567	50155569	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr19:50155567_50155569delAAG	uc002poq.2	+	7	2045_2047	c.1921_1923delAAG	c.(1921-1923)AAGdel	p.K645del		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	645	Arg-rich.|Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TGGCGGCAGCAAGAAGAAGAAGA	0.621													3	4	---	---	---	---					
TUBA3D	113457	broad.mit.edu	37	2	132238149	132238149	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chr2:132238149delT	uc002tsu.3	+	4	990	c.883delT	c.(883-885)TGCfs	p.C295fs		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	295					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CACCAATGCCTGCTTCGAGCC	0.597													10	285	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76920224	76920224	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-7686-01A-11D-2253-08	TCGA-HT-7686-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	22530a76-c1dd-4ff9-8503-ffcce2eeda5a	5cd72590-fbad-4fde-a315-5b5862bdddbf	g.chrX:76920224delA	uc004ecp.3	-	11	4085	c.3853delT	c.(3853-3855)TCCfs	p.S1285fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.S1247fs|ATRX_uc004eco.3_Frame_Shift_Del_p.S1070fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.S1217fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1285					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCATCAGAGGAAAGATTGGCT	0.373			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						13	50	---	---	---	---					
