Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC6A17	388662	broad.mit.edu	37	1	110740737	110740737	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr1:110740737G>A	uc009wfq.2	+	12	2316	c.1855G>A	c.(1855-1857)GCA>ACA	p.A619T		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	619	Helical; Name=12; (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		CTGGGCCATGGCACTCCTGAT	0.657000													3	32					0	0	0.014758	0	0
TAF5	6877	broad.mit.edu	37	10	105145230	105145230	+	Silent	SNP	C	T	T	rs145434074		TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr10:105145230C>T	uc001kwv.2	+	8	1835	c.1812C>T	c.(1810-1812)GGC>GGT	p.G604G	TAF5_uc010qqq.1_Intron	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	604	WD 3.				histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		TGTCAGGGGGCCATGACCGAG	0.413000													3	36					0	0	0.009096	0	0
RELT	84957	broad.mit.edu	37	11	73101914	73101914	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr11:73101914G>A	uc001otv.2	+	4	400	c.235G>A	c.(235-237)GCC>ACC	p.A79T	RELT_uc001otw.2_Missense_Mutation_p.A79T|RELT_uc009yto.1_5'UTR|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	79	TNFR-Cys.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						GAGGCTGGAGGCCCAGGTGGG	0.652000													3	74					0	0	0.014758	0	0
SACS	26278	broad.mit.edu	37	13	23908606	23908606	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr13:23908606C>T	uc001uon.2	-	10	9998	c.9409G>A	c.(9409-9411)GAT>AAT	p.D3137N	SACS_uc001uoo.2_Missense_Mutation_p.D2990N|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3137					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAACAATAATCAACTAAAAGT	0.373000													11	19					0	0	0.080935	0	0
HCN4	10021	broad.mit.edu	37	15	73615170	73615170	+	Silent	SNP	C	T	T			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr15:73615170C>T	uc002avp.2	-	8	4258	c.3264G>A	c.(3262-3264)GCG>GCA	p.A1088A		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	1088	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CTGGCTGAGACGCGGAGATGA	0.726000													4	3					0	0	0.014758	0	0
Unknown	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr16:70268158A>C	uc010cfp.1	-	3		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333000													3	6					0	0	0.115264	0	0
CTNS	1497	broad.mit.edu	37	17	3560060	3560060	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr17:3560060A>G	uc002fwb.2	+	9	1245	c.652A>G	c.(652-654)ATC>GTC	p.I218V	CTNS_uc002fwa.2_Missense_Mutation_p.I218V|CTNS_uc010ckj.2_Missense_Mutation_p.I218V|CTNS_uc010vrv.1_Missense_Mutation_p.I71V|CTNS_uc010vrw.1_Missense_Mutation_p.I110V	NM_004937	NP_004928	O60931	CTNS_HUMAN	cystinosin isoform 2	218	Helical; (Potential).				ATP metabolic process|brain development|cognition|glutathione metabolic process	integral to membrane|late endosome|lysosomal membrane	L-cystine transmembrane transporter activity				0				COAD - Colon adenocarcinoma(5;0.0829)	L-Cystine(DB00138)	CCTCACGCTGATCATCATCGT	0.592000													24	80					0	0	0.099896	0	0
TMC6	11322	broad.mit.edu	37	17	76120700	76120700	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr17:76120700G>C	uc002juj.1	-	7	922	c.796C>G	c.(796-798)CTG>GTG	p.L266V	TMC6_uc002jui.1_5'Flank|TMC6_uc010dhf.1_Missense_Mutation_p.L99V|TMC6_uc002juk.2_Missense_Mutation_p.L266V|TMC6_uc010dhg.1_Missense_Mutation_p.L266V|TMC6_uc002jul.1_Missense_Mutation_p.L266V|TMC6_uc002jum.3_Missense_Mutation_p.L57V|TMC6_uc002jun.3_Missense_Mutation_p.L266V|TMC6_uc002juo.2_Missense_Mutation_p.L39V|TMC6_uc010wtp.1_Missense_Mutation_p.L99V	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	266	Helical; (Potential).			L -> P (in Ref. 2; AAP69874).		endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AAGGCCACCAGCAGCAGCAGC	0.672000									Epidermodysplasia_Verruciformis_Familial_Clustering_of				2	16					0	0	0.009096	0	0
IL12RB1	3594	broad.mit.edu	37	19	18183118	18183118	+	Silent	SNP	C	T	T	rs141737618		TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr19:18183118C>T	uc002nhw.1	-	9	889	c.825G>A	c.(823-825)GCG>GCA	p.A275A	IL12RB1_uc010xqb.1_Silent_p.A275A|IL12RB1_uc002nhx.1_Silent_p.A315A|IL12RB1_uc002nhy.2_Silent_p.A275A	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	275	Extracellular (Potential).|Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						CCGTGCCAGGCGCCAGCCCTT	0.587000													9	19					0	0	0.058154	0	0
ZNF91	7644	broad.mit.edu	37	19	23544783	23544783	+	Missense_Mutation	SNP	C	T	T	rs410211		TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr19:23544783C>T	uc002nre.2	-	4	1111	c.998G>A	c.(997-999)CGT>CAT	p.R333H	ZNF91_uc010xrj.1_Missense_Mutation_p.R301H	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	333	C2H2-type 7.			R -> H (in Ref. 1; AAA59469).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAACGGCTAAAAGC	0.393000													4	66					0	0	0.021553	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	G	G			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358000													2	1					0	0	0.115264	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95494944	95494944	+	Splice_Site	SNP	C	G	G			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr2:95494944C>G	uc010fhp.2	-	8		c.797_splice	c.e8-1			NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						GCAGGAGGCCCTACAAAGCAA	0.358000													4	110					0	0	0.069234	0	0
SIRPA	140885	broad.mit.edu	37	20	1902301	1902301	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr20:1902301G>A	uc002wfq.2	+	4	1057	c.697G>A	c.(697-699)GTC>ATC	p.V233I	SIRPA_uc010zps.1_Missense_Mutation_p.V213I|SIRPA_uc002wfr.2_Missense_Mutation_p.V233I|SIRPA_uc002wfs.2_Missense_Mutation_p.V233I|SIRPA_uc002wft.2_Missense_Mutation_p.V233I	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	233	Ig-like C1-type 1.|Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GGTGGCCCACGTCACCTTGCA	0.617000													4	95					0	0	0.009096	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	A	A	rs7266938	by1000genomes	TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr20:29625877G>A	uc010ztl.1	+	2	63	c.31G>A	c.(31-33)GCC>ACC	p.A11T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GTACAGAATCGCCCTGAAATC	0.353000													5	68					0	0	0.014758	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	T	T			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr20:33345744C>T	uc002xav.2	-	8	3378	c.807G>A	c.(805-807)CAG>CAA	p.Q269Q	NCOA6_uc002xaw.2_Silent_p.Q269Q|NCOA6_uc010gew.1_Silent_p.Q226Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						gctgctgctgctgttgttgtt	0.313000													3	28					0	0	0.115264	0	0
FLNB	2317	broad.mit.edu	37	3	58149024	58149024	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr3:58149024G>A	uc003djj.2	+	43	7330	c.7165G>A	c.(7165-7167)GCC>ACC	p.A2389T	FLNB_uc010hne.2_Missense_Mutation_p.A2420T|FLNB_uc003djk.2_Missense_Mutation_p.A2378T|FLNB_uc010hnf.2_Missense_Mutation_p.A2365T|FLNB_uc003djl.2_Missense_Mutation_p.A2209T|FLNB_uc003djm.2_Missense_Mutation_p.A2196T|uc003djn.2_RNA	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2389	Filamin 23.|Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCTGGTGTCCGCCTATGGCAC	0.582000													3	66					0	0	0.009096	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572688	140572688	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr5:140572688G>T	uc003lix.2	+	1	737	c.563G>T	c.(562-564)GGC>GTC	p.G188V		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	188	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGATGAAGGCATGATATAT	0.498000													53	137					3.10202e-16	3.36052e-16	0.139131	1	0
CYP21A2	1589	broad.mit.edu	37	6	31974158	31974158	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr6:31974158A>G	uc010jtp.2	+	3	426	c.308A>G	c.(307-309)AAG>AGG	p.K103R	CYP21A2_uc011dpb.1_Missense_Mutation_p.K73R			P08686	CP21A_HUMAN	SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2; SubName: Full=Cytochrome P450 21-hydroxylase; SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_b; SubName: Full=DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B)); SubName: Full=cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNA;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						CTGGTGTCTAAGAACTACCCG	0.607000													3	11					0	0	0.009096	0	0
KLC4	89953	broad.mit.edu	37	6	43042382	43042382	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr6:43042382G>A	uc003otv.1	+	16	1909	c.1832G>A	c.(1831-1833)AGC>AAC	p.S611N	PTK7_uc003oub.1_5'Flank|PTK7_uc003ouc.1_5'Flank|PTK7_uc003oud.1_5'Flank|PTK7_uc003oue.1_5'Flank|PTK7_uc003ouf.1_5'Flank|PTK7_uc003oug.1_5'Flank|PTK7_uc011dve.1_5'Flank|KLC4_uc003otr.1_RNA|KLC4_uc011dvd.1_Missense_Mutation_p.S534N|KLC4_uc003otw.1_Missense_Mutation_p.S629N|KLC4_uc003otx.1_Missense_Mutation_p.S611N|KLC4_uc003oty.1_Missense_Mutation_p.S611N|KLC4_uc003otz.1_Missense_Mutation_p.S611N|PTK7_uc003oua.2_5'Flank	NM_201521	NP_958929	Q9NSK0	KLC4_HUMAN	kinesin-like 8 isoform a	611						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			skin(3)|ovary(1)	4			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			CTCAGTGCCAGCACCATGGAC	0.617000													3	84					0	0	0.115264	0	0
FOXR2	139628	broad.mit.edu	37	X	55650390	55650390	+	Silent	SNP	G	A	A			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chrX:55650390G>A	uc004duo.2	+	1	558	c.246G>A	c.(244-246)GTG>GTA	p.V82V		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	82					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						GGATGTGGGTGGACCCCAATA	0.552000													3	58					0	0	0.115264	0	0
BRWD3	254065	broad.mit.edu	37	X	79932312	79932312	+	Silent	SNP	G	A	A			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chrX:79932312G>A	uc004edt.2	-	41	5468	c.5205C>T	c.(5203-5205)ACC>ACT	p.T1735T	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Silent_p.T1331T|BRWD3_uc004edp.2_Silent_p.T1564T|BRWD3_uc004edq.2_Silent_p.T1331T|BRWD3_uc010nmj.1_Silent_p.T1331T|BRWD3_uc004edr.2_Silent_p.T1405T|BRWD3_uc004eds.2_Silent_p.T1331T|BRWD3_uc004edu.2_Silent_p.T1405T|BRWD3_uc004edv.2_Silent_p.T1331T|BRWD3_uc004edw.2_Silent_p.T1331T|BRWD3_uc004edx.2_Silent_p.T1331T|BRWD3_uc004edy.2_Silent_p.T1331T|BRWD3_uc004edz.2_Silent_p.T1405T|BRWD3_uc004eea.2_Silent_p.T1405T|BRWD3_uc004eeb.2_Silent_p.T1331T|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1735										ovary(4)	4						CTGAAAACATGGTATCAAATT	0.313000													5	86					0	0	0.029380	0	0
MTL5	9633	broad.mit.edu	37	11	68517872	68517872	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr11:68517872delC	uc001ooc.2	-	2	397	c.257delG	c.(256-258)GGCfs	p.G86fs	MTL5_uc001ood.1_Frame_Shift_Del_p.G86fs|MTL5_uc009ysi.1_Frame_Shift_Del_p.G86fs|MTL5_uc001ooe.2_Frame_Shift_Del_p.G86fs	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	86					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			GTCGCTGTCGCCCCCCGCGAG	0.751													2	4	---	---	---	---					
B4GALNT1	2583	broad.mit.edu	37	12	58025769	58025769	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr12:58025769delG	uc001spg.1	-	2	579	c.147delC	c.(145-147)CCCfs	p.P49fs	B4GALNT1_uc010sru.1_Frame_Shift_Del_p.P49fs|B4GALNT1_uc010srv.1_Frame_Shift_Del_p.P49fs|B4GALNT1_uc001sph.2_Frame_Shift_Del_p.P49fs|B4GALNT1_uc001spi.2_Frame_Shift_Del_p.P49fs|B4GALNT1_uc010srw.1_Frame_Shift_Del_p.P126fs	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	49	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CTGGCAGCTCGGGCCTGCGGG	0.726													2	4	---	---	---	---					
FBXL16	146330	broad.mit.edu	37	16	747263	747265	+	In_Frame_Del	DEL	TGG	-	-			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr16:747263_747265delTGG	uc002cjc.2	-	3	344_346	c.141_143delCCA	c.(139-144)TGCCAG>TGG	p.47_48CQ>W	FBXL16_uc002cja.2_5'Flank|FBXL16_uc002cjb.2_5'Flank	NM_153350	NP_699181	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	47_48	Pro-rich.										0		Hepatocellular(780;0.0218)				GGGTGGTGGCTGGCAGGGGCGGT	0.729													2	4	---	---	---	---					
HAUS8	93323	broad.mit.edu	37	19	17160706	17160707	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-HT-7691-01A-11D-2253-08	TCGA-HT-7691-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	efd30f39-5200-4c80-957d-a4f3898dd711	2891bd1f-d811-43da-b76f-60eb95191d34	g.chr19:17160706_17160707delGA	uc002nfe.2	-	11	1320_1321	c.1209_1210delTC	c.(1207-1212)TCTCGTfs	p.S403fs	HAUS8_uc002nff.2_Frame_Shift_Del_p.S402fs|HAUS8_uc002nfg.1_Frame_Shift_Del_p.S341fs|HAUS8_uc002nfh.1_Frame_Shift_Del_p.S402fs	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	403_404					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0						CTCCCTGAACGAGAGAGAGAGG	0.495													11	345	---	---	---	---					
