Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CLCNKB	1188	broad.mit.edu	37	1	16377498	16377498	+	Silent	SNP	G	A	A			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr1:16377498G>A	uc001axw.3	+	12	1262	c.1182G>A	c.(1180-1182)CCG>CCA	p.P394P	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.P394P|CLCNKB_uc001axy.3_Silent_p.P225P	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	394					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		GGTACCACCCGCGGTTCACCA	0.632000													10	49					0	0	0.069234	0	0
C1orf89	79363	broad.mit.edu	37	1	16559499	16559499	+	Silent	SNP	G	A	A			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr1:16559499G>A	uc001ayd.2	-	3	701	c.279C>T	c.(277-279)ACC>ACT	p.T93T		NM_030907	NP_112169	Q9BU20	RSG1_HUMAN	hypothetical protein LOC79363	93	Small GTPase-like.				cellular protein localization|cilium assembly|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|small GTPase mediated signal transduction	cilium|microtubule basal body	GTP binding				0		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.2e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;9.12e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		AAAATACCACGGTGGTCTGGA	0.552000													11	71					0	0	0.080935	0	0
HSP90B3P	343477	broad.mit.edu	37	1	92108899	92108899	+	Missense_Mutation	SNP	C	T	T	rs2493202	by1000genomes	TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr1:92108899C>T	uc010osx.1	+	3	926	c.926C>T	c.(925-927)TCT>TTT	p.S309F		NR_003130				SubName: Full=cDNA FLJ58812, highly similar to Endoplasmin (Heat shock protein 90kDa beta member 1);												0						TCTCCTCCATCTGTTGAACGA	0.433000													4	26					0	0	0.014758	0	0
SLC1A2	6506	broad.mit.edu	37	11	35336644	35336644	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr11:35336644G>C	uc001mwd.2	-	3	828	c.236C>G	c.(235-237)GCC>GGC	p.A79G	SLC1A2_uc001mwe.2_Missense_Mutation_p.A70G|SLC1A2_uc010rev.1_Missense_Mutation_p.A79G	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	79					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	CCCTGGGAAGGCTATTAACAT	0.478000													5	56					0	0	0.014758	0	0
AMHR2	269	broad.mit.edu	37	12	53825209	53825209	+	Silent	SNP	C	T	T			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr12:53825209C>T	uc001scx.1	+	11	1752	c.1674C>T	c.(1672-1674)GGC>GGT	p.G558G	AMHR2_uc009zmy.1_3'UTR	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	558	Cytoplasmic (Potential).				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)	TTCAGCAAGGCCCTTGTTCCA	0.517000									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				11	95					0	0	0.020292	0	0
ANKRD52	283373	broad.mit.edu	37	12	56645997	56645997	+	Silent	SNP	A	G	G			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr12:56645997A>G	uc001skm.3	-	14	1563	c.1473T>C	c.(1471-1473)TCT>TCC	p.S491S		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	491	ANK 15.						protein binding			ovary(2)	2						AGTGGAGGGGAGAGCAGCCTT	0.577000													12	87					0	0	0.093190	0	0
PGF	5228	broad.mit.edu	37	14	75416122	75416122	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr14:75416122C>T	uc010ase.1	-	3	599	c.253G>A	c.(253-255)GGC>AGC	p.G85S	PGF_uc001xqz.2_Missense_Mutation_p.G85S|PGF_uc001xra.2_Missense_Mutation_p.G84S|PGF_uc001xrb.2_Missense_Mutation_p.G85S|PGF_uc010asf.1_Silent_p.P70P	NM_002632	NP_002623	P49763	PLGF_HUMAN	placental growth factor, vascular endothelial	85					angiogenesis|cell differentiation|cell-cell signaling|positive regulation of cell division|positive regulation of cell proliferation|vascular endothelial growth factor receptor signaling pathway	extracellular region|membrane	growth factor activity|heparin binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00668)		CCGCAGCAGCCGGTGCAGCGC	0.652000													9	63					0	0	0.058154	0	0
Unknown	0	broad.mit.edu	37	15	20496622	20496622	+	RNA	SNP	A	T	T	rs2601530	by1000genomes	TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr15:20496622A>T	uc001ytf.1	+	6		c.675A>T								full-length cDNA clone CS0DI026YN18 of Placenta Cot 25-normalized of Homo sapiens (human).																		AAGTGGCCTCATGAAGGGGAA	0.438000													12	93					0	0	0.028581	0	0
SIN3A	25942	broad.mit.edu	37	15	75688839	75688839	+	Splice_Site	SNP	T	C	C			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr15:75688839T>C	uc002bai.2	-	13	2114	c.1855_splice	c.e13-1	p.L619_splice	SIN3A_uc002baj.2_Splice_Site_p.L619_splice|SIN3A_uc010uml.1_Splice_Site_p.L619_splice	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A						blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						TACATCAAGCTGAAGAGGAAG	0.313000													5	42					0	0	0.014758	0	0
IDH2	3418	broad.mit.edu	37	15	90631839	90631839	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr15:90631839T>A	uc002box.2	-	4	600	c.514A>T	c.(514-516)AGG>TGG	p.R172W	IDH2_uc010uqb.1_Missense_Mutation_p.R120W|IDH2_uc010uqc.1_Missense_Mutation_p.R42W|IDH2_uc010bnu.2_Intron	NM_002168	NP_002159	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+),	172		Substrate (By similarity).			2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding	p.R172K(170)|p.R172M(21)|p.R172S(12)|p.R172W(7)|p.R172?(7)|p.R172G(2)		haematopoietic_and_lymphoid_tissue(621)|central_nervous_system(80)|bone(7)|skin(3)	711	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			TGGGCGTGCCTGCCAATGGTG	0.627000			M		GBM								9	57					0	0	0.047766	0	0
MAST3	23031	broad.mit.edu	37	19	18248097	18248097	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr19:18248097G>A	uc002nhz.3	+	18	1934	c.1934G>A	c.(1933-1935)TGG>TAG	p.W645*		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	645	AGC-kinase C-terminal.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GCCCTGGACTGGGCAGGGCTT	0.622000													6	61					0	0	0.029380	0	0
Unknown	0	broad.mit.edu	37	19	20959168	20959168	+	RNA	SNP	C	G	G	rs7251612	by1000genomes	TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr19:20959168C>G	uc002npe.2	+	1		c.59C>G								Homo sapiens zinc finger protein 66, mRNA (cDNA clone MGC:87430 IMAGE:5270688), complete cds.																		TCTTCTTCTCCTAGAGGCCCA	0.587000													5	62					0	0	0.021553	0	0
RYR1	6261	broad.mit.edu	37	19	39026681	39026681	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr19:39026681G>A	uc002oit.2	+	82	11691	c.11561G>A	c.(11560-11562)GGG>GAG	p.G3854E	RYR1_uc002oiu.2_Missense_Mutation_p.G3849E|RYR1_uc002oiv.1_Missense_Mutation_p.G769E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3854					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AAGGCCGAGGGGCTGGGCATG	0.577000													4	17					0	0	0.009096	0	0
PNKP	11284	broad.mit.edu	37	19	50370414	50370414	+	Silent	SNP	A	G	G			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr19:50370414A>G	uc002pqh.2	-	1	100	c.48T>C	c.(46-48)CCT>CCC	p.P16P	PNKP_uc002pqg.2_5'Flank|PNKP_uc002pqi.2_5'UTR|PNKP_uc002pqj.2_Silent_p.P16P|PNKP_uc010enm.2_Silent_p.P16P|PNKP_uc002pqk.2_Silent_p.P16P	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	16					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		GCGCTCCCCCAGGGGGGCTCT	0.721000								Other_BER_factors					9	25					0	0	0.069234	0	0
MERTK	10461	broad.mit.edu	37	2	112777090	112777090	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr2:112777090G>A	uc002thk.1	+	16	2302	c.2180G>A	c.(2179-2181)CGA>CAA	p.R727Q	MERTK_uc002thl.1_Missense_Mutation_p.R551Q	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	727	Protein kinase.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TTAGCTGCTCGAAACTGCATG	0.458000													6	43					0	0	0.021553	0	0
C21orf99	149992	broad.mit.edu	37	21	14437495	14437495	+	Splice_Site	SNP	C	G	G	rs2821674	by1000genomes	TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr21:14437495C>G	uc002yja.3	+	9		c.2166_splice	c.e9-1			NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						CCTTGAGACACATTCAACTAG	0.254000													6	12					0	0	0.058154	0	0
TAB1	10454	broad.mit.edu	37	22	39814843	39814843	+	Silent	SNP	G	A	A	rs143506704	byFrequency	TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr22:39814843G>A	uc003axt.2	+	6	706	c.657G>A	c.(655-657)TCG>TCA	p.S219S	TAB1_uc003axr.2_Silent_p.S295S|TAB1_uc011aok.1_Silent_p.S53S|TAB1_uc003axu.1_Silent_p.S219S	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	219	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						TCCGTCTTTCGCAGCTGGGTG	0.542000													5	60					0	0	0.014758	0	0
POU1F1	5449	broad.mit.edu	37	3	87325590	87325590	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr3:87325590G>A	uc003dqq.1	-	1	148	c.23C>T	c.(22-24)TCG>TTG	p.S8L	POU1F1_uc010hoj.1_Missense_Mutation_p.S8L	NM_000306	NP_000297	P28069	PIT1_HUMAN	pituitary specific transcription factor 1	8					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|skin(1)	2	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		GGTATCAGCCGAAGTAAAAGC	0.458000													10	23					0	0	0.058154	0	0
IMPDH1	3614	broad.mit.edu	37	7	128040207	128040207	+	Silent	SNP	C	T	T			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr7:128040207C>T	uc011kol.1	-	6	667	c.561G>A	c.(559-561)GTG>GTA	p.V187V	IMPDH1_uc011kom.1_Silent_p.V182V|IMPDH1_uc003vmt.2_Silent_p.V162V|IMPDH1_uc003vmu.2_Silent_p.V272V|IMPDH1_uc003vmw.2_Silent_p.V262V|IMPDH1_uc011kon.1_Silent_p.V239V|IMPDH1_uc003vmv.2_Silent_p.V236V|IMPDH1_uc003vmx.2_Silent_p.V195V|IMPDH1_uc003vmy.2_Silent_p.V203V	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	187	CBS 2.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CTGCTGGAGCCACCACCAGTT	0.567000													21	129					0	0	0.076483	0	0
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	G	G			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961	Q9BRT8	CBWD1_HUMAN	COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCCACTGCACCTGAAAATATA	0.269000													8	97					0	0	0.047766	0	0
LOC442421	442421	broad.mit.edu	37	9	66499680	66499680	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr9:66499680C>A	uc004aee.1	+	1	490	c.490C>A	c.(490-492)CCC>ACC	p.P164T	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						TCATGTTAACCCCTTCCCAGG	0.582000													6	43					8.12818e-05	8.68875e-05	0.029380	1	0
EMG1	10436	broad.mit.edu	37	12	7080212	7080213	+	Splice_Site	INS	-	C	C	rs17857448		TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr12:7080212_7080213insC	uc001qsh.3	+	2	272	c.129_splice	c.e2+1	p.L43_splice	PHB2_uc001qsd.2_5'Flank|PHB2_uc010sft.1_5'Flank|PHB2_uc010sfu.1_5'Flank|EMG1_uc009zfo.2_RNA|EMG1_uc010sfv.1_RNA	NM_006331	NP_006322	Q92979	NEP1_HUMAN	ribosome biogenesis protein NEP1						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding				0						GAGGCCGTAGTTTATTGTGGTG	0.569													5	11	---	---	---	---					
C16orf74	404550	broad.mit.edu	37	16	85743879	85743881	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr16:85743879_85743881delGCT	uc002fjc.3	-	3	237_239	c.61_63delAGC	c.(61-63)AGCdel	p.S21del		NM_206967	NP_996850	Q96GX8	CP074_HUMAN	MGC17624 protein	21											0						CCTCGTCGTGGCTGCTGCTGCTG	0.635													2	4	---	---	---	---					
RNF160	26046	broad.mit.edu	37	21	30339206	30339206	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7856-01A-11D-2395-08	TCGA-HT-7856-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe1d5590-b04f-4196-86f0-d3887c399996	36437e51-9b37-4436-919f-9a5e82f7cf8f	g.chr21:30339206delT	uc002ymr.2	-	10	1758	c.1745delA	c.(1744-1746)AATfs	p.N582fs	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	536							ligase activity|zinc ion binding				0						AACCTTACCATTTTTTTTTTT	0.378													11	35	---	---	---	---					
