Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLHDC7A	127707	broad.mit.edu	37	1	18809173	18809173	+	Silent	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr1:18809173G>A	uc001bax.2	+	1	1750	c.1698G>A	c.(1696-1698)ACG>ACA	p.T566T	KLHDC7A_uc009vpg.2_Silent_p.T348T	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	566	Kelch 3.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCGCTCACGGGGATCTGGA	0.667000													15	29					0	0	0.002450	0	0
SLC9A1	6548	broad.mit.edu	37	1	27440680	27440680	+	Silent	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr1:27440680G>A	uc001bnm.2	-	2	1076	c.450C>T	c.(448-450)GGC>GGT	p.G150G	SLC9A1_uc010ofk.1_Intron|SLC9A1_uc001bnn.2_Silent_p.G150G	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	150	Extracellular (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	GGGGTGTCTCGCCTACACCCT	0.617000													28	40					0	0	0.008361	0	0
CYP4B1	1580	broad.mit.edu	37	1	47279204	47279204	+	Silent	SNP	C	T	T	rs147120348		TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr1:47279204C>T	uc001cqm.3	+	5	630	c.546C>T	c.(544-546)TGC>TGT	p.C182C	CYP4B1_uc009vyl.1_Silent_p.C19C|CYP4B1_uc001cqn.3_Silent_p.C182C|CYP4B1_uc009vym.2_Silent_p.C167C|CYP4B1_uc010omk.1_Silent_p.C19C|CYP4B1_uc010oml.1_Silent_p.C19C	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	182					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					ACATCTTCTGCGATGTGGGTC	0.582000													28	36					0	0	0.008361	0	0
LPHN2	23266	broad.mit.edu	37	1	82434955	82434955	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr1:82434955T>C	uc001dit.3	+	14	2747	c.2566T>C	c.(2566-2568)TTC>CTC	p.F856L	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.F856L|LPHN2_uc001div.2_Missense_Mutation_p.F856L|LPHN2_uc009wcd.2_Missense_Mutation_p.F856L|LPHN2_uc001diw.2_Missense_Mutation_p.F440L|LPHN2_uc009wce.1_5'Flank	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	869	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CATCTTCACCTTCTGCTTTTT	0.393000													47	120					0	0	0.003610	0	0
ETV3	2117	broad.mit.edu	37	1	157105467	157105467	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr1:157105467T>A	uc001fqr.2	-	3	369	c.80A>T	c.(79-81)GAG>GTG	p.E27V	ETV3_uc001fqt.2_Missense_Mutation_p.E27V	NM_001145312	NP_001138784	P41162	ETV3_HUMAN	ets variant gene 3 isoform 1	27							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(266;0.158)	Prostate(1639;0.174)				TGGGGATGACTCTGTTTTGTA	0.527000													44	70					0	0	0.009718	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232538163	232538163	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr1:232538163C>T	uc001hvg.2	-	20	5155	c.4997G>A	c.(4996-4998)CGA>CAA	p.R1666Q	SIPA1L2_uc001hvf.2_Missense_Mutation_p.R722Q	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1666	Potential.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CTGGAGTTGTCGAAGAATTAA	0.393000													20	24					0	0	0.003330	0	0
MAB21L1	4081	broad.mit.edu	37	13	36049234	36049234	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr13:36049234C>G	uc001uvc.2	-	1	1599	c.1042G>C	c.(1042-1044)GAG>CAG	p.E348Q	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	348					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		GTCAGGATCTCTCTTGCCAGT	0.433000													37	84					0	0	0.004289	0	0
POTEG	404785	broad.mit.edu	37	14	19562088	19562088	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr14:19562088A>G	uc001vuz.1	+	4	957	c.905A>G	c.(904-906)GAT>GGT	p.D302G	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	302										ovary(1)	1						AATGCACTGGATAGATATGGA	0.328000													17	3					0	0	0.004007	0	0
ADCY4	196883	broad.mit.edu	37	14	24787720	24787720	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr14:24787720G>A	uc001wov.2	-	25	3142	c.3136C>T	c.(3136-3138)CGG>TGG	p.R1046W	ADCY4_uc001wow.2_Missense_Mutation_p.R1046W|ADCY4_uc010toh.1_Missense_Mutation_p.R732W|ADCY4_uc001wox.2_Missense_Mutation_p.R1046W|ADCY4_uc001woy.2_Missense_Mutation_p.R1046W	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	1046	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		ATGACACCCCGGCTGTAGCAG	0.562000													27	59					0	0	0.003954	0	0
MYO9A	4649	broad.mit.edu	37	15	72172772	72172772	+	Silent	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr15:72172772G>A	uc002atl.3	-	29	5999	c.5526C>T	c.(5524-5526)AAC>AAT	p.N1842N	MYO9A_uc002atk.2_Silent_p.N637N|MYO9A_uc002atm.1_Silent_p.N638N	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1842	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CCAAAGCCACGTTGCTAATCT	0.438000													45	100					0	0	0.003214	0	0
ALDH1A3	220	broad.mit.edu	37	15	101425495	101425495	+	Silent	SNP	C	T	T	rs58142816	byFrequency	TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr15:101425495C>T	uc002bwn.3	+	2	227	c.123C>T	c.(121-123)CAC>CAT	p.H41H	ALDH1A3_uc010bpb.2_Silent_p.H41H|ALDH1A3_uc010bpa.1_Silent_p.H41H	NM_000693	NP_000684	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1A3	41					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	ATGAATGGCACGAATCCAAGA	0.348000													18	36					0	0	0.007413	0	0
SMG1	23049	broad.mit.edu	37	16	18937330	18937330	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr16:18937330T>C	uc002dfm.2	-	1	397	c.34A>G	c.(34-36)AGC>GGC	p.S12G		NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	12	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						ccgccgccgctgcTCAGCCGA	0.627000													3	13					0	0	0.004672	0	0
NFAT5	10725	broad.mit.edu	37	16	69726213	69726213	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr16:69726213G>A	uc002exm.1	+	12	3639	c.2431G>A	c.(2431-2433)GTT>ATT	p.V811I	NFAT5_uc002exi.2_Missense_Mutation_p.V735I|NFAT5_uc002exj.1_Missense_Mutation_p.V735I|NFAT5_uc002exk.1_Missense_Mutation_p.V735I|NFAT5_uc002exl.1_Missense_Mutation_p.V829I|NFAT5_uc002exn.1_Missense_Mutation_p.V828I|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	811					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GTTATCTTCAGTTTTATTTTC	0.448000													44	86					0	0	0.009718	0	0
LPO	4025	broad.mit.edu	37	17	56342147	56342147	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr17:56342147C>T	uc002ivt.2	+	10	1647	c.1331C>T	c.(1330-1332)CCA>CTA	p.P444L	LPO_uc010wns.1_Missense_Mutation_p.P385L|LPO_uc010dcp.2_Missense_Mutation_p.P361L|LPO_uc010dcq.2_Missense_Mutation_p.P115L|LPO_uc010dcr.2_Missense_Mutation_p.P7L	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	444					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						TGGATACCCCCATATCAAGGC	0.478000													35	47					0	0	0.002445	0	0
MEX3C	51320	broad.mit.edu	37	18	48703396	48703396	+	Silent	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr18:48703396G>A	uc002lfc.3	-	2	1305	c.1305C>T	c.(1303-1305)CGC>CGT	p.R435R		NM_016626	NP_057710	Q5U5Q3	MEX3C_HUMAN	ring finger and KH domain containing 2	435						cytoplasm|nucleus	RNA binding|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		Colorectal(6;0.003)|all_epithelial(6;0.0473)		Colorectal(16;0.0175)|READ - Rectum adenocarcinoma(32;0.15)		TCATTCTTGCGCGGCTAGGAG	0.453000													6	89					0	0	0.001168	0	0
PCSK4	54760	broad.mit.edu	37	19	1481915	1481915	+	Missense_Mutation	SNP	C	T	T	rs145279692		TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr19:1481915C>T	uc002ltb.1	-	15	2173	c.2111G>A	c.(2110-2112)CGC>CAC	p.R704H	C19orf25_uc010xgn.1_5'Flank|C19orf25_uc002lsy.3_5'Flank|C19orf25_uc010dsk.2_5'Flank|C19orf25_uc010xgo.1_5'Flank|C19orf25_uc002lsx.1_5'Flank|PCSK4_uc002lsz.2_Missense_Mutation_p.R191H|PCSK4_uc002lta.2_3'UTR	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	704					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGGGCAGCGGTGGTGGGG	0.711000													8	16					0	0	0.006214	0	0
ZNF256	10172	broad.mit.edu	37	19	58453810	58453810	+	Silent	SNP	T	C	C			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr19:58453810T>C	uc002qqu.2	-	3	601	c.366A>G	c.(364-366)GCA>GCG	p.A122A	ZNF256_uc010euj.2_5'UTR	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	122					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GTTTCCTACATGCCCCGTCTG	0.458000													50	93					0	0	0.003610	0	0
TANC1	85461	broad.mit.edu	37	2	160050870	160050870	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr2:160050870G>A	uc002uag.2	+	17	3119	c.2845G>A	c.(2845-2847)GAA>AAA	p.E949K	TANC1_uc010zcm.1_Missense_Mutation_p.E941K|TANC1_uc010fom.1_Missense_Mutation_p.E755K	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	949	ANK 2.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TGGCCACGAGGAAGTTGTCAC	0.552000													25	45					0	0	0.003954	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								20	57					0	0	0.001882	0	0
FEV	54738	broad.mit.edu	37	2	219846970	219846970	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr2:219846970G>C	uc002vji.1	-	3	718	c.136C>G	c.(136-138)CAG>GAG	p.Q46E		NM_017521	NP_059991	Q99581	FEV_HUMAN	FEV (ETS oncogene family)	46					cell differentiation|nervous system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity		EWSR1/FEV(10)|FUS/FEV(2)	bone(10)|soft_tissue(2)	12		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCTGGATCTGTCCGCTGCCT	0.697000			T	EWSR1| FUS	Ewing sarcoma								8	6					0	0	0.003080	0	0
SP140	11262	broad.mit.edu	37	2	231150502	231150502	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr2:231150502G>A	uc002vql.2	+	17	1715	c.1600G>A	c.(1600-1602)GAA>AAA	p.E534K	SP140_uc010zma.1_RNA|SP140_uc002vqn.2_Missense_Mutation_p.E420K|SP140_uc002vqm.2_Missense_Mutation_p.E474K|SP140_uc010fxl.2_Missense_Mutation_p.E507K	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	534					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GGTCTCCAGTGAAAAGAAGGC	0.458000													51	80					0	0	0.003610	0	0
SSTR4	6754	broad.mit.edu	37	20	23017075	23017075	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr20:23017075C>T	uc002wsr.2	+	1	1019	c.955C>T	c.(955-957)CGC>TGC	p.R319C		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	319	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity	p.R319H(1)		ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGACAACTTCCGCCGATTCTT	0.587000													44	52					0	0	0.003610	0	0
POTEH	23784	broad.mit.edu	37	22	16279207	16279207	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr22:16279207T>C	uc010gqp.2	-	4	1068	c.1016A>G	c.(1015-1017)GAT>GGT	p.D339G	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.D58G|POTEH_uc002zlj.1_Missense_Mutation_p.D174G	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	339										skin(1)	1						TCCATATCTATCCAGTGCATT	0.318000													15	258					0	0	0.008871	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659578	24659578	+	RNA	SNP	A	G	G			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr22:24659578A>G	uc002zzs.3	+	7		c.3310A>G			uc011ajp.1_5'Flank	NR_003714				Homo sapiens mRNA; cDNA DKFZp434P211 (from clone DKFZp434P211).												0						TGCGCAGGCCAACACTCACTG	0.617000													4	16					0	0	0.001168	0	0
C7	730	broad.mit.edu	37	5	40955639	40955639	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr5:40955639A>G	uc003jmh.2	+	10	1358	c.1244A>G	c.(1243-1245)CAA>CGA	p.Q415R	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	415	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AATCTTCCTCAAGTCATAAAA	0.413000													4	90					0	0	0.009096	0	0
LOC441089	441089	broad.mit.edu	37	5	79647695	79647695	+	RNA	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr5:79647695G>A	uc010jaj.1	-	1		c.91C>T				NR_003665				Homo sapiens CRSP8 pseudogene (LOC441089), non-coding RNA.												0						ACCTGCTCACGCTGGAGCGCA	0.592000													20	33					0	0	0.008871	0	0
ALDH7A1	501	broad.mit.edu	37	5	125885898	125885898	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr5:125885898G>A	uc003ktx.2	-	15	1597	c.1405C>T	c.(1405-1407)CGC>TGC	p.R469C	ALDH7A1_uc003ktv.2_Missense_Mutation_p.R90C|ALDH7A1_uc003kty.2_RNA|ALDH7A1_uc011cxa.1_Missense_Mutation_p.R432C	NM_001182	NP_001173	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	469					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	CCAAGCCAGCGAAAGATTCTG	0.348000													22	61					0	0	0.002780	0	0
MRAP2	112609	broad.mit.edu	37	6	84799071	84799071	+	Silent	SNP	G	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr6:84799071G>A	uc003pkg.3	+	4	679	c.489G>A	c.(487-489)AAG>AAA	p.K163K	MRAP2_uc010kbo.2_Silent_p.K77K	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	163					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						GGCTCATGAAGTTTGACATCC	0.493000													44	58					0	0	0.009718	0	0
ABCA13	154664	broad.mit.edu	37	7	48335325	48335325	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr7:48335325A>C	uc003toq.2	+	21	9009	c.8984A>C	c.(8983-8985)AAT>ACT	p.N2995T	ABCA13_uc010kys.1_Missense_Mutation_p.N69T	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2995					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TCCTCGCCGAATCAGCTAAAT	0.393000													43	93					0	0	0.002852	0	0
PMS2L11	441263	broad.mit.edu	37	7	76631555	76631555	+	RNA	SNP	C	T	T	rs61737188	by1000genomes	TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr7:76631555C>T	uc003ufw.3	+	4		c.696C>T			PMS2L11_uc011kgn.1_RNA	NR_023383				Homo sapiens cDNA FLJ59034 complete cds, moderately similar to Protein deltex-2.												0						GGCAATCGGGCCCCTGGCTGT	0.607000													3	18					0	0	0.009096	0	0
TRPA1	8989	broad.mit.edu	37	8	72946552	72946552	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr8:72946552C>A	uc003xza.2	-	22	2791	c.2616G>T	c.(2614-2616)AGG>AGT	p.R872S	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	872	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CAACTGTAGACCTCAACAAAG	0.294000													26	34					7.92952e-12	8.48274e-12	0.003954	1	0
WWP1	11059	broad.mit.edu	37	8	87443690	87443690	+	Silent	SNP	A	C	C			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr8:87443690A>C	uc003ydt.2	+	13	1723	c.1443A>C	c.(1441-1443)ACA>ACC	p.T481T	WWP1_uc010mai.2_Silent_p.T257T	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	481	WW 3.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						ACACAAAAACAACCCAGTGGG	0.348000													22	67					0	0	0.002299	0	0
LOC442421	442421	broad.mit.edu	37	9	66500808	66500808	+	RNA	SNP	T	G	G			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr9:66500808T>G	uc004aed.1	+	3		c.901T>G								Homo sapiens similar to prostaglandin E receptor 4, subtype EP4; PGE receptor, EP4 subtype; prostaglandin E2 receptor, mRNA (cDNA clone IMAGE:5288780).												0						CCACCTACGGTCGGTTGTGTG	0.632000													7	21					0	0	0.003080	0	0
KIAA0649	9858	broad.mit.edu	37	9	138379182	138379182	+	Silent	SNP	C	T	T			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr9:138379182C>T	uc004cfr.1	+	4	3375	c.2826C>T	c.(2824-2826)ACC>ACT	p.T942T		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	942						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		CCAGGAGCACCAGCGGCGGTG	0.652000													59	53					0	0	0.003610	0	0
SPANXE	171489	broad.mit.edu	37	X	140785749	140785749	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chrX:140785749C>T	uc004fbq.2	-	2	260	c.167G>A	c.(166-168)AGG>AAG	p.R56K		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	56						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					AAAGTTCCTCCTGTAGCGAAC	0.488000													6	169					0	0	0.003080	0	0
A1CF	29974	broad.mit.edu	37	10	52596001	52596002	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr10:52596001_52596002insT	uc001jjj.2	-	6	624_625	c.436_437insA	c.(436-438)ACCfs	p.T146fs	A1CF_uc010qhn.1_Frame_Shift_Ins_p.T154fs|A1CF_uc001jji.2_Frame_Shift_Ins_p.T146fs|A1CF_uc001jjh.2_Frame_Shift_Ins_p.T154fs|A1CF_uc010qho.1_Frame_Shift_Ins_p.T154fs|A1CF_uc009xov.2_Frame_Shift_Ins_p.T146fs	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	146	RRM 2.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						TCTCTTTTTGGTTTTTGGGATG	0.446													39	103	---	---	---	---					
PAK1	5058	broad.mit.edu	37	11	77069990	77069992	+	In_Frame_Del	DEL	CAT	-	-			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr11:77069990_77069992delCAT	uc001oyh.3	-	6	1081_1083	c.548_550delATG	c.(547-552)GATGCT>GCT	p.D183del	PAK1_uc010rso.1_In_Frame_Del_p.D85del|PAK1_uc001oyg.3_In_Frame_Del_p.D183del|PAK1_uc001oyi.1_In_Frame_Del_p.D183del|PAK1_uc010rsn.1_5'UTR	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	183	Interaction with CRIPAK.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					GGTGGGGTAGcatcatcatcatc	0.429													7	170	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546506	11546508	+	In_Frame_Del	DEL	TTG	-	-			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr12:11546506_11546508delTTG	uc010shk.1	-	3	539_541	c.504_506delCAA	c.(502-507)AACAAG>AAG	p.N168del		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			ACTTCGGGACTTGTTGTCTCCTT	0.596													7	704	---	---	---	---					
ALKBH1	8846	broad.mit.edu	37	14	78161070	78161102	+	Splice_Site	DEL	ACAAGACTTACCTCAGGAACTCTTTGCTCTGTT	-	-			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr14:78161070_78161102delACAAGACTTACCTCAGGAACTCTTTGCTCTGTT	uc001xuc.1	-	3	464	c.455_splice	c.e3+1	p.R152_splice	ALKBH1_uc001xud.1_Intron	NM_006020	NP_006011	Q13686	ALKB1_HUMAN	alkylated DNA repair protein alkB homolog						DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)|skin(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		ATTCTGATTGACAAGACTTACCTCAGGAACTCTTTGCTCTGTTCCCACAGATC	0.403													8	142	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7573996	7574003	+	Frame_Shift_Del	DEL	AGCTCTCG	-	-	rs121912662		TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr17:7573996_7574003delAGCTCTCG	uc002gim.2	-	10	1218_1225	c.1024_1031delCGAGAGCT	c.(1024-1032)CGAGAGCTGfs	p.R342fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Frame_Shift_Del_p.R210fs|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Frame_Shift_Del_p.R342fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	342_344	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Nuclear export signal.|Interaction with HIPK2.		L -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).|L -> R (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R342*(49)|p.0?(7)|p.R342fs*3(5)|p.E343*(4)|p.R342P(3)|p.L344fs*23(2)|p.R342Q(2)|p.L344P(2)|p.L344fs*22(1)|p.?(1)|p.R342_N345delRELN(1)|p.E343fs*3(1)|p.L344R(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCTCATTCAGCTCTCGGAACATCTCG	0.505		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	10	---	---	---	---					
TRIP12	9320	broad.mit.edu	37	2	230724205	230724206	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr2:230724205_230724206insC	uc002vpw.1	-	3	292_293	c.183_184insG	c.(181-186)GGGCAGfs	p.G61fs	TRIP12_uc002vpx.1_Frame_Shift_Ins_p.G103fs|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Frame_Shift_Ins_p.G61fs	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	61_62					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TTAGGCACCTGCCCCGTTTTTT	0.450													7	266	---	---	---	---					
MAFA	389692	broad.mit.edu	37	8	144511954	144511956	+	In_Frame_Del	DEL	TGG	-	-			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chr8:144511954_144511956delTGG	uc003yyc.1	-	1	621_623	c.621_623delCCA	c.(619-624)CACCAT>CAT	p.207_208HH>H		NM_201589	NP_963883	Q8NHW3	MAFA_HUMAN	v-maf musculoaponeurotic fibrosarcoma oncogene	207_208	His-rich.				insulin secretion|nitric oxide mediated signal transduction|response to glucose stimulus	nucleus	protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.237)			CGCGCCGCCAtggtggtggtggt	0.581										HNSCC(29;0.082)			4	2	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76938029	76938029	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7873-01B-11D-2395-08	TCGA-HT-7873-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc65ab63-a507-4dbf-becf-93fc7d1bea3d	b7ec26c5-3d2d-4164-9de2-7202c49e4429	g.chrX:76938029delG	uc004ecp.3	-	9	2951	c.2719delC	c.(2719-2721)CGAfs	p.R907fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.R869fs|ATRX_uc004eco.3_Frame_Shift_Del_p.R692fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.R839fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.R878fs|ATRX_uc010nly.1_Frame_Shift_Del_p.R852fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	907					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.R907*(1)		haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTAGGAAGTCGATCTCTTAAT	0.418			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						154	38	---	---	---	---					
