Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PANK4	55229	broad.mit.edu	37	1	2444388	2444388	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr1:2444388C>T	uc001ajm.1	-	13	1675	c.1666G>A	c.(1666-1668)GCG>ACG	p.A556T	PANK4_uc010nza.1_Missense_Mutation_p.A517T	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	556					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		TTCACCAGCGCCAGCTGCCGT	0.682000													6	137					0	0	0.001984	0	0
AHDC1	27245	broad.mit.edu	37	1	27875777	27875777	+	Silent	SNP	C	T	T	rs151218177		TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr1:27875777C>T	uc009vsy.2	-	6	3819	c.2850G>A	c.(2848-2850)CCG>CCA	p.P950P	AHDC1_uc009vsz.1_Silent_p.P950P	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	950							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		TGGCTGAGGGCGGGGGCACCA	0.672000													55	61					0	0	0.014410	0	0
YIPF1	54432	broad.mit.edu	37	1	54331952	54331952	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr1:54331952C>G	uc001cvu.2	-	9	1089	c.752G>C	c.(751-753)CGT>CCT	p.R251P	YIPF1_uc001cvv.2_RNA|YIPF1_uc001cvw.2_RNA|YIPF1_uc001cvx.2_RNA|YIPF1_uc001cvy.2_RNA	NM_018982	NP_061855	Q9Y548	YIPF1_HUMAN	Yip1 domain family, member 1	251	Cytoplasmic (Potential).					integral to membrane|transport vesicle				large_intestine(1)|ovary(1)	2						GTTATCCTCACGAACAGCTGG	0.483000													44	64					0	0	0.009718	0	0
OR4C16	219428	broad.mit.edu	37	11	55339961	55339961	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr11:55339961C>T	uc010rih.1	+	1	358	c.358C>T	c.(358-360)CGC>TGC	p.R120C		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GGCTGTTGACCGCTATGTGGA	0.517000													105	135					0	0	0.014410	0	0
OR4D6	219983	broad.mit.edu	37	11	59224594	59224594	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr11:59224594G>A	uc010rku.1	+	1	161	c.161G>A	c.(160-162)CGC>CAC	p.R54H		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGTGAGTCCCGCCTACACACT	0.458000													7	112					0	0	0.001984	0	0
ZNF259	8882	broad.mit.edu	37	11	116657243	116657243	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr11:116657243T>C	uc001ppp.2	-	4	512	c.479A>G	c.(478-480)GAC>GGC	p.D160G	ZNF259_uc009yzd.2_Missense_Mutation_p.D160G|ZNF259_uc001ppq.2_Missense_Mutation_p.D106G	NM_003904	NP_003895	O75312	ZPR1_HUMAN	zinc finger protein 259	160					cell proliferation|signal transduction	cytoplasm|nucleolus					0	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		TGCAGGCTGGTCCTGCTCCAG	0.438000													20	50					0	0	0.014323	0	0
FKBP4	2288	broad.mit.edu	37	12	2910516	2910516	+	Silent	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr12:2910516G>A	uc001qkz.2	+	9	1464	c.1266G>A	c.(1264-1266)GAG>GAA	p.E422E		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	FK506 binding protein 52	422					negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging				0			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	CTGAGGAGGAGAACAAGGTGA	0.557000													33	190					0	0	0.013726	0	0
KIAA0748	9840	broad.mit.edu	37	12	55356531	55356531	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr12:55356531G>A	uc001sgn.3	-	9	1261	c.1151C>T	c.(1150-1152)TCG>TTG	p.S384L	KIAA0748_uc001sgl.3_Missense_Mutation_p.S246L|KIAA0748_uc001sgm.3_Missense_Mutation_p.S131L|KIAA0748_uc010spb.1_Missense_Mutation_p.S131L|KIAA0748_uc010spc.1_Missense_Mutation_p.S246L|KIAA0748_uc010spd.1_Missense_Mutation_p.S384L|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	384										ovary(1)|central_nervous_system(1)	2						CTTGGGGTTCGAATCCAGAGT	0.507000													33	34					0	0	0.012213	0	0
MAPKAPK5	8550	broad.mit.edu	37	12	112327906	112327906	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr12:112327906T>G	uc001tta.2	+	13	1544	c.1285T>G	c.(1285-1287)TGC>GGC	p.C429G	MAPKAPK5_uc001tsz.2_Missense_Mutation_p.C427G|MAPKAPK5_uc001ttb.2_Missense_Mutation_p.C362G	NM_139078	NP_620777	Q8IW41	MAPK5_HUMAN	MAP kinase-activated protein kinase 5 isoform 2	429	Potential.				signal transduction	cytoplasm|nucleus	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)	3						TAACCGGGAATGCAAACTCCT	0.428000													4	6					0	0	0.009096	0	0
PXMP2	5827	broad.mit.edu	37	12	133277886	133277886	+	Silent	SNP	G	A	A	rs139134478	byFrequency	TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr12:133277886G>A	uc001ukt.2	+	4	515	c.450G>A	c.(448-450)CCG>CCA	p.P150P	PGAM5_uc010tbr.1_RNA	NM_018663	NP_061133	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	150	Peroxisomal (Potential).					integral to membrane|peroxisomal membrane	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		GCTTCTGGCCGGCGCTGAGGA	0.612000													6	115					0	0	0.001168	0	0
SLC39A9	55334	broad.mit.edu	37	14	69908908	69908908	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr14:69908908G>A	uc001xle.2	+	3	1008	c.328G>A	c.(328-330)GTT>ATT	p.V110I	SLC39A9_uc010aqx.2_Missense_Mutation_p.V110I|SLC39A9_uc001xlf.3_Missense_Mutation_p.V110I|SLC39A9_uc001xlg.3_RNA	NM_018375	NP_060845	Q9NUM3	S39A9_HUMAN	solute carrier family 39 (zinc transporter),	110	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		CTATATTGGTGTTTCCCTCGT	0.483000													31	193					0	0	0.007291	0	0
LTK	4058	broad.mit.edu	37	15	41796600	41796600	+	Silent	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr15:41796600G>A	uc001zoa.3	-	19	2464	c.2286C>T	c.(2284-2286)CAC>CAT	p.H762H	LTK_uc001zob.3_Silent_p.H701H|LTK_uc010ucx.1_Silent_p.H632H|LTK_uc010bcg.2_Silent_p.H460H	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	762	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GCTCAGGCTCGTGCTGCCAAC	0.592000										TSP Lung(18;0.14)			6	67					0	0	0.003080	0	0
SRRM2	23524	broad.mit.edu	37	16	2816330	2816330	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr16:2816330G>A	uc002crk.2	+	11	6350	c.5801G>A	c.(5800-5802)CGT>CAT	p.R1934H	SRRM2_uc002crj.1_Missense_Mutation_p.R1838H|SRRM2_uc002crl.1_Missense_Mutation_p.R1934H|SRRM2_uc010bsu.1_Missense_Mutation_p.R1838H	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1934	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						ACCCGCCGTCGTTCAAGGTCT	0.582000													57	71					0	0	0.014410	0	0
ZNF319	57567	broad.mit.edu	37	16	58030901	58030901	+	Silent	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr16:58030901C>T	uc002emx.1	-	2	1892	c.1269G>A	c.(1267-1269)GCG>GCA	p.A423A		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCCGCTCGGCCGCGCCGGGCA	0.657000													14	40					0	0	0.003163	0	0
RTN4RL1	146760	broad.mit.edu	37	17	1840572	1840572	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr17:1840572C>T	uc002ftp.2	-	2	563	c.544G>A	c.(544-546)GGC>AGC	p.G182S		NM_178568	NP_848663	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1 precursor	182	LRR 6.				axon regeneration	anchored to plasma membrane	receptor activity				0						AGCTTGTTGCCGTGGAGAAAC	0.602000													8	63					0	0	0.004482	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	17					0	0	0.002450	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62856443	62856443	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr17:62856443T>C	uc002jey.2	-	11	4352	c.3821A>G	c.(3820-3822)GAC>GGC	p.D1274G	LRRC37A3_uc010wqg.1_Missense_Mutation_p.D392G|LRRC37A3_uc002jex.1_Missense_Mutation_p.D251G|LRRC37A3_uc010wqf.1_Missense_Mutation_p.D312G|LRRC37A3_uc010dek.1_Missense_Mutation_p.D280G	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1274	Extracellular (Potential).					integral to membrane					0						GTGGGTTAAGTCTTTCCATCT	0.458000													21	154					0	0	0.014323	0	0
USH1G	124590	broad.mit.edu	37	17	72916511	72916511	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr17:72916511G>C	uc002jme.1	-	2	603	c.420C>G	c.(418-420)TTC>TTG	p.F140L	USH1G_uc010wro.1_Missense_Mutation_p.F37L	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	140					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					CCGCCTCGCGGAAGGCCTTGT	0.672000													4	67					0	0	0.000602	0	0
CNDP1	84735	broad.mit.edu	37	18	72201914	72201914	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr18:72201914A>T	uc002llq.2	+	1	223	c.12A>T	c.(10-12)AAA>AAT	p.K4N		NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	4					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		TGGATCCCAAACTCGGGAGAA	0.537000													13	33					0	0	0.013537	0	0
MAST3	23031	broad.mit.edu	37	19	18260436	18260436	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr19:18260436C>T	uc002nhz.3	+	27	3830	c.3830C>T	c.(3829-3831)CCG>CTG	p.P1277L		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	1277							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						TTCGATGAGCCGCAGGAGGAG	0.667000													8	32					0	0	0.003080	0	0
IL29	282618	broad.mit.edu	37	19	39788648	39788648	+	Silent	SNP	G	A	A	rs150964916	byFrequency	TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr19:39788648G>A	uc002okv.2	+	3	391	c.294G>A	c.(292-294)ACG>ACA	p.T98T		NM_172140	NP_742152	Q8IU54	IL29_HUMAN	interleukin 29 precursor	98					defense response to virus|negative regulation of cell proliferation|negative regulation of interleukin-13 production|negative regulation of interleukin-5 production|negative regulation of memory T cell differentiation|negative regulation of transcription, DNA-dependent|negative regulation of type 2 immune response|positive regulation of immune response|positive regulation of interferon-gamma production|positive regulation of MHC class I biosynthetic process|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of STAT protein	extracellular space|interleukin-28 receptor complex	cytokine activity|interleukin-28 receptor binding				0	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			TGGCCCTGACGCTGAAGGTCC	0.642000													5	75					0	0	0.001168	0	0
REG1A	5967	broad.mit.edu	37	2	79348733	79348733	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr2:79348733C>T	uc002snz.2	+	3	213	c.110C>T	c.(109-111)CCA>CTA	p.P37L	REG1A_uc010ffx.1_Missense_Mutation_p.P37L|REG1A_uc010ysd.1_Missense_Mutation_p.P37L	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	37	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						ATCAGCTGCCCAGAAGGCACC	0.527000													62	272					0	0	0.014410	0	0
RND3	390	broad.mit.edu	37	2	151328168	151328168	+	Silent	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr2:151328168G>A	uc002txe.2	-	4	700	c.456C>T	c.(454-456)CAC>CAT	p.H152H	RND3_uc002txf.2_Silent_p.H151H|RND3_uc002txg.2_Silent_p.H152H|RND3_uc010zbv.1_Intron|RND3_uc010zbw.1_Silent_p.H23H	NM_005168	NP_005159	P61587	RND3_HUMAN	ras homolog gene family, member E precursor	152					actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.106)		GCGTCTGCCTGTGATTGGAGA	0.418000													5	114					0	0	0.001168	0	0
SCN2A	6326	broad.mit.edu	37	2	166179921	166179921	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr2:166179921A>G	uc002udc.2	+	12	2217	c.1927A>G	c.(1927-1929)AAG>GAG	p.K643E	SCN2A_uc002udd.2_Missense_Mutation_p.K643E|SCN2A_uc002ude.2_Missense_Mutation_p.K643E	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	643					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CATGAATGGGAAGATGCATAG	0.617000													6	46					0	0	0.001168	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								45	58					0	0	0.013114	0	0
DIDO1	11083	broad.mit.edu	37	20	61511961	61511961	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr20:61511961C>T	uc002ydr.1	-	16	5611	c.5347G>A	c.(5347-5349)GAA>AAA	p.E1783K	DIDO1_uc002yds.1_Missense_Mutation_p.E1783K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1783	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					ATATTCTCTTCTGGAAACGGA	0.612000													16	197					0	0	0.003163	0	0
DIDO1	11083	broad.mit.edu	37	20	61511992	61511992	+	Silent	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr20:61511992C>T	uc002ydr.1	-	16	5580	c.5316G>A	c.(5314-5316)CCG>CCA	p.P1772P	DIDO1_uc002yds.1_Silent_p.P1772P	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1772	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CCCTTGGTCCCGGGAAATTGG	0.632000													11	198					0	0	0.013537	0	0
TPTE	7179	broad.mit.edu	37	21	11012923	11012923	+	RNA	SNP	T	C	C			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr21:11012923T>C	uc002yis.1	-	9		c.1698A>G						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTACCTAGCTTTTTTACTTTT	0.289000													4	42					0	0	0.009096	0	0
USP16	10600	broad.mit.edu	37	21	30419419	30419419	+	Silent	SNP	T	C	C			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr21:30419419T>C	uc002ymy.2	+	14	1990	c.1788T>C	c.(1786-1788)AAT>AAC	p.N596N	USP16_uc002ymx.2_Silent_p.N595N|USP16_uc002ymw.2_Silent_p.N596N|USP16_uc011acm.1_Silent_p.N581N|USP16_uc011acn.1_Silent_p.N262N|USP16_uc011aco.1_Silent_p.N286N	NM_006447	NP_006438	Q9Y5T5	UBP16_HUMAN	ubiquitin specific protease 16 isoform a	596					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4						AGATTCTGAATGATAGTCATA	0.378000													25	131					0	0	0.002780	0	0
PDHA2	5161	broad.mit.edu	37	4	96761529	96761529	+	Silent	SNP	A	G	G			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr4:96761529A>G	uc003htr.3	+	1	291	c.228A>G	c.(226-228)GCA>GCG	p.A76A		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	76					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	AATTGAAGGCAGATCAGCTGT	0.537000													6	133					0	0	0.003080	0	0
NEUROG2	63973	broad.mit.edu	37	4	113436146	113436146	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr4:113436146C>T	uc003ias.2	-	2	813	c.486G>A	c.(484-486)TGG>TGA	p.W162*		NM_024019	NP_076924	Q9H2A3	NGN2_HUMAN	neurogenin 2	162	Helix-loop-helix motif.				positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			skin(2)|central_nervous_system(1)	3		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		CGGTGAGTGCCCAGATGTAGT	0.552000													9	37					0	0	0.006214	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563635	140563635	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr5:140563635G>A	uc003liv.2	+	1	2656	c.1501G>A	c.(1501-1503)GCC>ACC	p.A501T	PCDHB16_uc010jfw.1_Missense_Mutation_p.A173T	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	501	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGCCCCTCGCCTCCCTGGT	0.677000													9	139					0	0	0.010729	0	0
SPINK5	11005	broad.mit.edu	37	5	147484546	147484546	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr5:147484546A>G	uc003lox.2	+	16	1535	c.1462A>G	c.(1462-1464)AAA>GAA	p.K488E	SPINK5_uc010jgs.1_Missense_Mutation_p.K460E|SPINK5_uc010jgr.2_Missense_Mutation_p.K469E|SPINK5_uc003low.2_Missense_Mutation_p.K488E|SPINK5_uc003loy.2_Missense_Mutation_p.K488E	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	488	Kazal-like 7.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAAAGGCTAAAAGAGAAGC	0.284000													4	28					0	0	0.009096	0	0
CLINT1	9685	broad.mit.edu	37	5	157240156	157240156	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr5:157240156C>G	uc003lxj.1	-	5	622	c.432G>C	c.(430-432)AGG>AGC	p.R144S	CLINT1_uc003lxi.1_Missense_Mutation_p.R126S|CLINT1_uc011ddv.1_Missense_Mutation_p.R144S	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	144	ENTH.				endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTTCACGAAGCCTGTCGTCAT	0.418000													4	88					0	0	0.000602	0	0
RUNX2	860	broad.mit.edu	37	6	45390466	45390466	+	Silent	SNP	A	G	G			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr6:45390466A>G	uc011dvx.1	+	3	405	c.195A>G	c.(193-195)CAA>CAG	p.Q65Q	RUNX2_uc011dvy.1_Silent_p.Q65Q|RUNX2_uc003oxt.2_Silent_p.Q51Q	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	65	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						agcagcagcaacagcagcagc	0.274000													4	31					0	0	0.000602	0	0
SYNE1	23345	broad.mit.edu	37	6	152697565	152697565	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr6:152697565T>C	uc010kiw.2	-	58	9877	c.9275A>G	c.(9274-9276)GAT>GGT	p.D3092G	SYNE1_uc003qot.3_Missense_Mutation_p.D3099G|SYNE1_uc003qou.3_Missense_Mutation_p.D3092G|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_Missense_Mutation_p.D170G|SYNE1_uc010kjb.1_3'UTR	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3092	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTGAGGTATATCAAAACACTT	0.358000										HNSCC(10;0.0054)			43	44					0	0	0.011902	0	0
LOC389458	389458	broad.mit.edu	37	7	5024540	5024540	+	Splice_Site	SNP	G	A	A	rs9689983	by1000genomes	TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr7:5024540G>A	uc003snr.2	+	2	104	c.-209_splice	c.e2-1		RNF216L_uc003snp.3_Splice_Site|RNF216L_uc003snq.3_Splice_Site|RNF216L_uc010ksr.2_Splice_Site|RNF216L_uc011jwe.1_Intron					Synthetic construct DNA, clone: pF1KB3788, Homo sapiens RBAK gene for RB-associated KRAB repressor, complete cds, without stop codon, in Flexi system.												0						TCTCGTTTCAGTTGCCTAAAA	0.393000													3	41					0	0	0.004672	0	0
ITGB8	3696	broad.mit.edu	37	7	20441726	20441726	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr7:20441726A>G	uc003suu.2	+	10	2369	c.1664A>G	c.(1663-1665)TAT>TGT	p.Y555C	ITGB8_uc011jyh.1_Missense_Mutation_p.Y420C	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	555	III.|Cysteine-rich tandem repeats.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						TCTTGTCCATATCACCATGGA	0.363000													9	131					0	0	0.008291	0	0
AVL9	23080	broad.mit.edu	37	7	32599062	32599062	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr7:32599062G>A	uc003tcv.1	+	10	1347	c.1201G>A	c.(1201-1203)GCC>ACC	p.A401T	AVL9_uc011kai.1_Missense_Mutation_p.A401T|AVL9_uc010kwj.1_Missense_Mutation_p.A242T	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	401						integral to membrane					0						CATGCCCCTGGCCATCTTCAC	0.388000													28	40					0	0	0.005443	0	0
IMMP2L	83943	broad.mit.edu	37	7	110303732	110303732	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr7:110303732G>A	uc003vfq.1	-	6	897	c.454C>T	c.(454-456)CCC>TCC	p.P152S	IMMP2L_uc010ljr.1_Missense_Mutation_p.P152S	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	152					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		CGCTCTGGGGGCCACAGGATA	0.448000													5	93					0	0	0.000602	0	0
PCM1	5108	broad.mit.edu	37	8	17794714	17794714	+	Silent	SNP	T	C	C			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr8:17794714T>C	uc003wyi.3	+	4	590	c.168T>C	c.(166-168)AGT>AGC	p.S56S	PCM1_uc011kyh.1_Silent_p.S56S|PCM1_uc003wyj.3_Silent_p.S56S|PCM1_uc003wyg.2_Silent_p.S56S|PCM1_uc003wyh.2_Silent_p.S56S|PCM1_uc010lta.1_Silent_p.S56S	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	56					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		GTGTAGAAAGTGATAAAAGAG	0.373000			T	RET|JAK2	papillary thyroid|CML|MPD								4	15					0	0	0.009096	0	0
FAM164A	51101	broad.mit.edu	37	8	79598805	79598805	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr8:79598805G>A	uc003ybd.2	+	4	416	c.314G>A	c.(313-315)GGC>GAC	p.G105D		NM_016010	NP_057094	Q96GY0	F164A_HUMAN	hypothetical protein LOC51101	105										ovary(1)	1						AAAGAGGGTGGCAAACTTCCT	0.398000													3	43					0	0	0.009096	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736148	12736148	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chrX:12736148T>C	uc004cuz.1	+	16	3709	c.3203T>C	c.(3202-3204)GTG>GCG	p.V1068A	FRMPD4_uc011mij.1_Missense_Mutation_p.V1060A	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1068					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TTTGGTACTGTGTCTTCACGA	0.507000													7	157					0	0	0.003080	0	0
PPP1R3F	89801	broad.mit.edu	37	X	49142309	49142309	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chrX:49142309C>T	uc004dnh.1	+	4	1173	c.1157C>T	c.(1156-1158)CCG>CTG	p.P386L	PPP1R3F_uc011mnd.1_Missense_Mutation_p.P57L|PPP1R3F_uc004dni.2_Missense_Mutation_p.P40L|PPP1R3F_uc004dnj.1_Missense_Mutation_p.P40L	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	386	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					TCTGACGTTCCGATGACTGGC	0.577000													23	38					0	0	0.003330	0	0
SERPINA7	6906	broad.mit.edu	37	X	105280577	105280577	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chrX:105280577A>G	uc004eme.1	-	1	489	c.473T>C	c.(472-474)GTC>GCC	p.V158A	SERPINA7_uc010npd.2_Missense_Mutation_p.V158A|SERPINA7_uc010npe.1_Missense_Mutation_p.V158A	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	158					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	GGTAGAAAAGACTTCAGTCTC	0.438000													15	281					0	0	0.002450	0	0
TP53	7157	broad.mit.edu	37	17	7577076	7577077	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr17:7577076_7577077insC	uc002gim.2	-	8	1055_1056	c.861_862insG	c.(859-864)GAGAATfs	p.E287fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Ins_p.E287fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.E155fs|TP53_uc010cng.1_Frame_Shift_Ins_p.E155fs|TP53_uc002gii.1_Frame_Shift_Ins_p.E155fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.E287fs|TP53_uc010cni.1_Frame_Shift_Ins_p.E287fs|TP53_uc002gij.2_Frame_Shift_Ins_p.E287fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	287_288	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		N -> D (in a sporadic cancer; somatic mutation).|N -> Y (in sporadic cancers; somatic mutation).|N -> S (in sporadic cancers; somatic mutation).|N -> K (in sporadic cancers; somatic mutation).|N -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.N288fs*13(17)|p.E287*(8)|p.0?(7)|p.E287K(6)|p.E287E(5)|p.N288Y(3)|p.E287G(2)|p.E287D(2)|p.?(2)|p.R283fs*16(2)|p.N288fs*57(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.E287V(1)|p.E287fs*17(1)|p.E287A(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.N288D(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.N288fs*18(1)|p.N288fs*17(1)|p.N288fs*15(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGCGGAGATTCTCTTCCTCTG	0.569		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			33	42	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45247389	45247389	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr17:45247389delT	uc002ild.3	-	4	398	c.271delA	c.(271-273)ATCfs	p.I91fs	CDC27_uc002ile.3_Frame_Shift_Del_p.I91fs|CDC27_uc002ilf.3_Frame_Shift_Del_p.I91fs|CDC27_uc010wkp.1_Frame_Shift_Del_p.I30fs|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	91	TPR 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						CCAGATAAGATTTGTTCCCCT	0.323													7	119	---	---	---	---					
LYPD3	27076	broad.mit.edu	37	19	43969653	43969655	+	In_Frame_Del	DEL	AGC	-	-	rs141441894	byFrequency	TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr19:43969653_43969655delAGC	uc002owl.1	-	1	177_179	c.69_71delGCT	c.(67-72)CTGCTT>CTT	p.23_24LL>L	LYPD3_uc002owm.2_In_Frame_Del_p.23_24LL>L	NM_014400	NP_055215	O95274	LYPD3_HUMAN	GPI-anchored metastasis-associated protein	23_24						anchored to plasma membrane				pancreas(1)	1		Prostate(69;0.0153)				ACCTCCGCGAAGCAGCAGCAGCA	0.675													7	172	---	---	---	---					
STXBP5L	9515	broad.mit.edu	37	3	120628568	120628569	+	In_Frame_Ins	INS	-	CGC	CGC			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr3:120628568_120628569insCGC	uc003eec.3	+	2	283_284	c.143_144insCGC	c.(142-144)GAG>GACGCG	p.48_48E>DA	STXBP5L_uc011bji.1_In_Frame_Ins_p.48_48E>DA	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	48					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GTTCTCAGAGAGGAAATTCAGG	0.480													17	31	---	---	---	---					
PLCH1	23007	broad.mit.edu	37	3	155215187	155215187	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chr3:155215187delT	uc011bok.1	-	14	2057	c.1780delA	c.(1780-1782)ACCfs	p.T594fs	PLCH1_uc011boj.1_Frame_Shift_Del_p.T594fs|PLCH1_uc011bol.1_Frame_Shift_Del_p.T576fs	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	594					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AGCTTCATGGTTTTCCTTCGG	0.468													56	82	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76939673	76939674	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-7884-01B-11D-2395-08	TCGA-HT-7884-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e8c13d36-7c29-4e40-8f16-98ea5d746d85	3dc318b4-b8f0-4bc3-87b8-6b29b91f13bf	g.chrX:76939673_76939674insT	uc004ecp.3	-	9	1306_1307	c.1074_1075insA	c.(1072-1077)AAACTGfs	p.K358fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.K320fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.K143fs|ATRX_uc004ecr.2_Frame_Shift_Ins_p.K319fs|ATRX_uc010nlx.1_Frame_Shift_Ins_p.K358fs|ATRX_uc010nly.1_Frame_Shift_Ins_p.K303fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	358_359					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GTCTCAATCAGTTTTTTTGCCT	0.366			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						71	136	---	---	---	---					
