Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IQGAP3	128239	broad.mit.edu	37	1	156499981	156499981	+	Silent	SNP	G	C	C			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr1:156499981G>C	uc001fpf.2	-	34	4395	c.4320C>G	c.(4318-4320)GTC>GTG	p.V1440V		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1440					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGTTCCGCAGGACGCGCCGCT	0.647													6	11					0	0	1	0	0
RXRG	6258	broad.mit.edu	37	1	165389159	165389159	+	Silent	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr1:165389159G>A	uc001gda.2	-	3	690	c.390C>T	c.(388-390)AGC>AGT	p.S130S		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	130	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GAGATCCGGGGCTGGTGGATG	0.522													12	37					0	0	1	0	0
H3F3A	3020	broad.mit.edu	37	1	226252059	226252059	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr1:226252059C>T	uc001hpw.2	+	2	122	c.7C>T	c.(7-9)CGT>TGT	p.R3C	H3F3A_uc010pvl.1_Missense_Mutation_p.R3C	NM_005324	NP_005315	P84243	H33_HUMAN	H3 histone, family 3B	3					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding				0	Breast(184;0.179)			GBM - Glioblastoma multiforme(131;0.203)		TACCATGGCTCGTACAAAGCA	0.498											OREG0014293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	18					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228461596	228461596	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr1:228461596G>A	uc009xez.1	+	18	5307	c.5263G>A	c.(5263-5265)GAT>AAT	p.D1755N	OBSCN_uc001hsn.2_Missense_Mutation_p.D1755N	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1755	Fibronectin type-III 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTGGCTCAAGGATGGTGTGGA	0.647													8	9					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236744701	236744701	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr1:236744701T>A	uc001hyd.1	-	20	2701	c.2576A>T	c.(2575-2577)GAT>GTT	p.D859V	HEATR1_uc009xgh.1_Missense_Mutation_p.D102V	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	859					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CTGAAAAACATCTTCTAGATG	0.328													9	39					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453													4	19					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89624228	89624228	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr10:89624228T>A	uc001kfb.2	+	2	1033	c.2T>A	c.(1-3)ATG>AAG	p.M1K	KILLIN_uc009xti.2_5'Flank	NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	1					activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(13)|p.0?(12)|p.M1fs*7(1)|p.M1fs*24(1)|p.M1T(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTCCCAGACATGACAGCCATC	0.507		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			11	19					0	0	1	0	0
IFITM1	8519	broad.mit.edu	37	11	314978	314978	+	Silent	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr11:314978C>T	uc001loy.3	+	2	423	c.243C>T	c.(241-243)ACC>ACT	p.T81T		NM_003641	NP_003632	P13164	IFM1_HUMAN	interferon induced transmembrane protein 1	81	Cytoplasmic (Potential).				negative regulation of cell proliferation|regulation of immune response|response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane	protein binding|receptor signaling protein activity				0		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		ATGCCTCCACCGCCAAGTGCC	0.572													16	51					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96181099	96181099	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr12:96181099G>A	uc001tei.2	-	2	652	c.203C>T	c.(202-204)ACG>ATG	p.T68M	NTN4_uc009ztf.2_Missense_Mutation_p.T68M|NTN4_uc009ztg.2_Missense_Mutation_p.T31M	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	68	Laminin N-terminal.			T -> K (in Ref. 1; AAG30822).	axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						AGTCAGATCCGTGTTCTCACT	0.537													11	39					0	0	1	0	0
ACADS	35	broad.mit.edu	37	12	121176335	121176335	+	Splice_Site	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr12:121176335G>A	uc001tza.3	+	7	914	c.796_splice	c.e7-1	p.Q266_splice	ACADS_uc010szl.1_Splice_Site_p.Q262_splice|ACADS_uc001tzb.3_Intron	NM_000017	NP_000008	P16219	ACADS_HUMAN	short-chain acyl-CoA dehydrogenase precursor							mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(2)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	GGTCCCCACAGCAAACCCTGG	0.682													10	34					0	0	1	0	0
F7	2155	broad.mit.edu	37	13	113770051	113770051	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr13:113770051C>T	uc001vsv.2	+	6	559	c.508C>T	c.(508-510)CGC>TGC	p.R170C	F7_uc010agp.1_Missense_Mutation_p.R163C|F7_uc001vsw.2_Missense_Mutation_p.R148C|F7_uc010tjt.1_Missense_Mutation_p.R101C	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	170	EGF-like 2.				anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	GGGCACCAAGCGCTCCTGTCG	0.617													8	27					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88652226	88652226	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr14:88652226G>A	uc001xwo.2	-	7	1727	c.1270C>T	c.(1270-1272)CGC>TGC	p.R424C	KCNK10_uc001xwm.2_Missense_Mutation_p.R429C|KCNK10_uc001xwn.2_Missense_Mutation_p.R429C	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	424	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						CCCTTCAGGCGCAGGTTGTTG	0.607													19	39					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43574758	43574758	+	Silent	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr15:43574758G>A	uc001zrf.1	-	8	1070	c.1065C>T	c.(1063-1065)AAC>AAT	p.N355N		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	355					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	CCTGCCACCCGTTGTATCCTG	0.557													3	6					0	0	1	0	0
SCAPER	49855	broad.mit.edu	37	15	77064287	77064287	+	Silent	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr15:77064287C>T	uc002bby.2	-	9	1103	c.1044G>A	c.(1042-1044)GTG>GTA	p.V348V	SCAPER_uc002bbx.2_Silent_p.V102V|SCAPER_uc002bbz.1_Silent_p.V213V|SCAPER_uc002bca.1_Silent_p.V213V|SCAPER_uc002bcb.1_Silent_p.V348V|SCAPER_uc002bcc.1_Silent_p.V348V	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	347						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						CCAATGTACTCACTGTGAACT	0.338													7	28					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3781375	3781375	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr16:3781375G>A	uc002cvv.2	-	30	5194	c.4990C>T	c.(4990-4992)CGC>TGC	p.R1664C	CREBBP_uc002cvw.2_Missense_Mutation_p.R1626C	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1664	Interaction with TRERF1.		R -> H (in RSTS1; abolishes acetyltransferase activity).		cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AAGGCGTCGCGCCCATCCATG	0.642			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				6	17					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24373167	24373167	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr16:24373167C>T	uc002dmf.2	+	4	2131	c.931C>T	c.(931-933)CGC>TGC	p.R311C		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	311					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		GGCCAACAGGCGCACCACGCC	0.562													13	41					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50325794	50325794	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr16:50325794C>T	uc002egd.1	+	3	791	c.523C>T	c.(523-525)CGG>TGG	p.R175W	ADCY7_uc002egb.1_Missense_Mutation_p.R175W|ADCY7_uc002egc.1_Missense_Mutation_p.R175W	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	175					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	ACCCAGTGTCCGGGTGGGGCT	0.652													12	32					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88967963	88967963	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr16:88967963G>A	uc002fmm.1	-	2	439	c.253C>T	c.(253-255)CCT>TCT	p.P85S	CBFA2T3_uc002fml.1_Missense_Mutation_p.P24S|CBFA2T3_uc010cif.1_Missense_Mutation_p.P24S|CBFA2T3_uc002fmn.1_Missense_Mutation_p.P85S	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	85	Mediates localization to the nucleus (By similarity).|Pro-rich.|Mediates interaction with PDE7A (in isoform 2).|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		GATGCGGCAGGCGGTGGGGGC	0.701			T	RUNX1	AML								16	35					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5462410	5462410	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr17:5462410G>A	uc002gci.2	-	4	2161	c.1606C>T	c.(1606-1608)CGG>TGG	p.R536W	NLRP1_uc002gcg.1_Missense_Mutation_p.R536W|NLRP1_uc002gck.2_Missense_Mutation_p.R536W|NLRP1_uc002gcj.2_Missense_Mutation_p.R536W|NLRP1_uc002gcl.2_Missense_Mutation_p.R536W|NLRP1_uc002gch.3_Missense_Mutation_p.R536W|NLRP1_uc010clh.2_Missense_Mutation_p.R536W	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	536	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				TTTTCCTTCCGCTTCATCTGC	0.547													28	70					0	0	1	0	0
PIK3R5	23533	broad.mit.edu	37	17	8794082	8794082	+	Silent	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr17:8794082G>A	uc002glt.2	-	7	697	c.630C>T	c.(628-630)GAC>GAT	p.D210D	PIK3R5_uc010vuz.1_Silent_p.D210D|PIK3R5_uc002glu.3_Intron|PIK3R5_uc010coa.1_Silent_p.D210D|PIK3R5_uc010cob.1_Translation_Start_Site	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	210					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GGCCCGGGACGTCACAGTGGG	0.632													3	13					0	0	1	0	0
GSDMB	55876	broad.mit.edu	37	17	38073447	38073447	+	Silent	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr17:38073447C>T	uc010cwj.2	-	1	128	c.123G>A	c.(121-123)GGG>GGA	p.G41G	GSDMB_uc010cwk.2_RNA|GSDMB_uc010cwl.2_RNA|GSDMB_uc010cwm.2_RNA|GSDMB_uc002htg.2_Silent_p.G41G|GSDMB_uc002hth.2_Silent_p.G41G|GSDMB_uc010wem.1_Silent_p.G41G	NM_001042471	NP_001035936	Q8TAX9	GSDMB_HUMAN	gasdermin B isoform 1	41						cytoplasm				breast(1)|pancreas(1)	2						TTCTCTTCTCCCCCACCAGAT	0.483													31	83					0	0	1	0	0
SHD	56961	broad.mit.edu	37	19	4284902	4284902	+	Splice_Site	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr19:4284902G>A	uc002lzw.2	+	4	2179	c.716_splice	c.e4+1	p.P239_splice	SHD_uc010dtu.2_Splice_Site_p.P239_splice	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming												0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAAACAGCCGTGAGTGGGGA	0.587													23	43					0	0	1	0	0
SRBD1	55133	broad.mit.edu	37	2	45620175	45620175	+	Silent	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr2:45620175C>T	uc002rus.2	-	20	2683	c.2607G>A	c.(2605-2607)GAG>GAA	p.E869E	SRBD1_uc010yoc.1_Silent_p.E388E	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	869					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			CTGCAATTTTCTCCATTCCTT	0.403													26	40					0	0	1	0	0
PDK1	5163	broad.mit.edu	37	2	173431601	173431601	+	Missense_Mutation	SNP	A	T	T	rs148646668		TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr2:173431601A>T	uc002uhr.2	+	6	809	c.709A>T	c.(709-711)AGG>TGG	p.R237W	PDK1_uc010zdz.1_Missense_Mutation_p.R82W|PDK1_uc010zea.1_RNA|PDK1_uc002uhq.1_Missense_Mutation_p.R257W|PDK1_uc002uhs.2_Missense_Mutation_p.R237W|PDK1_uc010zeb.1_Missense_Mutation_p.R257W	NM_002610	NP_002601	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase 1 precursor	237	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(3)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.12)			TGAAAATGCTAGGCGTCTGTG	0.323									Autosomal_Dominant_Polycystic_Kidney_Disease				3	16					0	0	1	0	0
FAM182B	728882	broad.mit.edu	37	20	25848606	25848606	+	RNA	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr20:25848606G>A	uc002wvd.1	-	1		c.181C>T								Homo sapiens cDNA FLJ30282 fis, clone BRACE2002803.												0						atcaccgtccgggcaggcctg	0													3	3					0	0	1	0	0
SPATA2	9825	broad.mit.edu	37	20	48522793	48522793	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr20:48522793G>A	uc010gie.2	-	3	1276	c.926C>T	c.(925-927)CCG>CTG	p.P309L	SPATA2_uc002xuw.2_Missense_Mutation_p.P309L|SPATA2_uc010zyn.1_Missense_Mutation_p.P172L	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	309					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			AAGCACATCCGGGCTGCCGTG	0.637													30	65					0	0	1	0	0
CBLN4	140689	broad.mit.edu	37	20	54579018	54579018	+	Silent	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr20:54579018C>T	uc002xxa.2	-	1	995	c.210G>A	c.(208-210)AAG>AAA	p.K70K		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	70	C1q.					cell junction|extracellular region|synapse				ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			AGAAGGCGACCTTGGAGTTGG	0.637													36	104					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60895628	60895628	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr20:60895628C>T	uc002ycq.2	-	50	6813	c.6746G>A	c.(6745-6747)CGG>CAG	p.R2249Q		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2249	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCGCCTAGCCGCCGTGCGTC	0.687													4	6					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45817649	45817649	+	Missense_Mutation	SNP	C	T	T	rs149619816	byFrequency	TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr21:45817649C>T	uc002zet.1	+	14	2165	c.1952C>T	c.(1951-1953)GCG>GTG	p.A651V	TRPM2_uc002zeu.1_Missense_Mutation_p.A651V|TRPM2_uc002zew.1_Missense_Mutation_p.A651V|TRPM2_uc010gpt.1_Missense_Mutation_p.A651V|TRPM2_uc002zex.1_Missense_Mutation_p.A437V|TRPM2_uc002zey.1_Missense_Mutation_p.A164V	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	651	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGCATCGCAGCGGCCTTGGCC	0.622													7	17					0	0	1	0	0
Unknown	0	broad.mit.edu	37	22	25855471	25855471	+	RNA	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr22:25855471C>T	uc003abt.2	+	5		c.678C>T			uc003abu.2_RNA|uc003abv.2_RNA					Homo sapiens cDNA clone IMAGE:3542716, partial cds.																		CTTTGGGGCCCGTCACCCTCA	0.622													12	38					0	0	1	0	0
CCBP2	1238	broad.mit.edu	37	3	42907140	42907140	+	Silent	SNP	A	G	G			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr3:42907140A>G	uc003cme.2	+	3	1325	c.1146A>G	c.(1144-1146)AAA>AAG	p.K382K	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmf.2_Silent_p.K382K|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	382	Cytoplasmic (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		TGGGGAATAAATCAGCCTGAG	0.393													14	24					0	0	1	0	0
IMPDH2	3615	broad.mit.edu	37	3	49065256	49065256	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr3:49065256A>T	uc003cvt.2	-	5	510	c.418T>A	c.(418-420)TGC>AGC	p.C140S		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	140	CBS 1.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	GGGATACCGCAGAAACCATGC	0.542													15	43					0	0	1	0	0
FAIM	55179	broad.mit.edu	37	3	138341217	138341217	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr3:138341217G>A	uc003esr.2	+	3	559	c.299G>A	c.(298-300)TGG>TAG	p.W100*	FAIM_uc003eso.1_Nonsense_Mutation_p.W134*|FAIM_uc003esp.2_Nonsense_Mutation_p.W134*|FAIM_uc003esq.2_Nonsense_Mutation_p.W122*|FAIM_uc003ess.2_Nonsense_Mutation_p.W100*	NM_001033032	NP_001028204	Q9NVQ4	FAIM1_HUMAN	Fas apoptotic inhibitory molecule isoform c	100					apoptosis	cytoplasm					0						ACCAATACTTGGGTATTACAC	0.333													14	24					0	0	1	0	0
BOD1L	259282	broad.mit.edu	37	4	13600828	13600828	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr4:13600828T>C	uc003gmz.1	-	10	7813	c.7696A>G	c.(7696-7698)AGT>GGT	p.S2566G	BOD1L_uc010idr.1_Missense_Mutation_p.S1903G	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2566							DNA binding			ovary(5)|breast(1)	6						TTGGTGGTACTGGTTTTCAAG	0.468											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	11					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145636526	145636526	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr4:145636526G>A	uc003ijs.1	+	10	2277	c.1622G>A	c.(1621-1623)GGG>GAG	p.G541E		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	541						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GGCACTAGTGGGTCCTGTAGA	0.428													15	33					0	0	1	0	0
RNF175	285533	broad.mit.edu	37	4	154636798	154636798	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr4:154636798C>T	uc003int.2	-	7	1020	c.647G>A	c.(646-648)CGG>CAG	p.R216Q	RNF175_uc003inu.1_Missense_Mutation_p.R88Q	NM_173662	NP_775933	Q8N4F7	RN175_HUMAN	ring finger protein 175	216						integral to membrane	zinc ion binding			ovary(1)|pancreas(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				TGTAGGCAACCGGCTGACACT	0.502													10	18					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23522989	23522989	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr5:23522989T>A	uc003jgo.2	+	8	1059	c.877T>A	c.(877-879)TGG>AGG	p.W293R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	293	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TGGATACTCCTGGCTGGTAAG	0.493										HNSCC(3;0.000094)			19	48					0	0	1	0	0
PRICKLE4	29964	broad.mit.edu	37	6	41753227	41753227	+	Silent	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr6:41753227C>T	uc011duf.1	+	6	779	c.531C>T	c.(529-531)TGC>TGT	p.C177C	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_5'Flank|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	137	LIM zinc-binding 1.					nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AACTCTACTGCGGCCGTCATC	0.622													18	46					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138601169	138601169	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr6:138601169G>A	uc003qhu.2	+	14	2329	c.2329G>A	c.(2329-2331)GTG>ATG	p.V777M		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	777	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GACCAGCGGCGTGCTGATGGT	0.547													17	26					0	0	1	0	0
CDCA7L	55536	broad.mit.edu	37	7	21956473	21956473	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr7:21956473C>T	uc010kuk.2	-	2	184	c.64G>A	c.(64-66)GAT>AAT	p.D22N	CDCA7L_uc003sve.3_5'UTR|CDCA7L_uc010kul.2_Missense_Mutation_p.D22N|CDCA7L_uc003svf.3_Missense_Mutation_p.D22N|CDCA7L_uc011jyk.1_Missense_Mutation_p.D22N	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	22					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						TCTTCATCATCACTGGGGGCG	0.463													30	130					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55211080	55211080	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr7:55211080G>A	uc003tqk.2	+	3	569	c.323G>A	c.(322-324)AGA>AAA	p.R108K	EGFR_uc003tqh.2_Missense_Mutation_p.R108K|EGFR_uc003tqi.2_Missense_Mutation_p.R108K|EGFR_uc003tqj.2_Missense_Mutation_p.R108K|EGFR_uc010kzg.1_Missense_Mutation_p.R108K|EGFR_uc011kco.1_Missense_Mutation_p.R55K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	108	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R108K(7)|p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGATCATCAGAGGAAATATG	0.423		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			692	44					0	0	1	0	0
CALN1	83698	broad.mit.edu	37	7	71571179	71571179	+	Silent	SNP	G	A	A	rs139754746		TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr7:71571179G>A	uc003twa.3	-	3	746	c.219C>T	c.(217-219)AGC>AGT	p.S73S	CALN1_uc003twb.3_Silent_p.S115S|CALN1_uc003twc.3_Silent_p.S73S	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	73	EF-hand 2.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				GCTCCACCTCGCTTGGCATGT	0.592													10	33					0	0	1	0	0
LEP	3952	broad.mit.edu	37	7	127892092	127892092	+	Silent	SNP	C	T	T			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr7:127892092C>T	uc003vml.2	+	2	78	c.21C>T	c.(19-21)TGC>TGT	p.C7C	LEP_uc003vmm.2_Silent_p.C7C	NM_000230	NP_000221	P41159	LEP_HUMAN	leptin precursor	7					adult feeding behavior|energy reserve metabolic process|negative regulation of appetite|placenta development|positive regulation of developmental growth	extracellular space					0						GAACCCTGTGCGGATTCTTGT	0.488													19	87					0	0	1	0	0
B4GALT1	2683	broad.mit.edu	37	9	33135343	33135343	+	Silent	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr9:33135343G>A	uc003zsg.2	-	2	681	c.492C>T	c.(490-492)GGC>GGT	p.G164G		NM_001497	NP_001488	P15291	B4GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	164	Lumenal (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	basolateral plasma membrane|brush border membrane|desmosome|external side of plasma membrane|extracellular region|glycocalyx|Golgi cisterna membrane|Golgi trans cisterna|integral to membrane	alpha-tubulin binding|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|beta-tubulin binding|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity|protein binding|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(29;0.0084)	GBM - Glioblastoma multiforme(74;0.121)	N-Acetyl-D-glucosamine(DB00141)	CATAGCGGCCGCCCATCTTCA	0.557													12	32					0	0	1	0	0
FAM75C1	441452	broad.mit.edu	37	9	90535986	90535986	+	Silent	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr9:90535986G>A	uc010mqi.2	+	4	1193	c.1164G>A	c.(1162-1164)TCG>TCA	p.S388S	FAM75C1_uc004apq.3_Silent_p.S371S	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GCCCTGCGTCGCAGAATAAAG	0.517													52	158					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123812513	123812513	+	Silent	SNP	C	T	T	rs35352264	byFrequency	TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr9:123812513C>T	uc004bkv.2	-	1	42	c.12G>A	c.(10-12)TTG>TTA	p.L4L	C5_uc010mvm.1_Silent_p.L4L|C5_uc010mvn.1_Silent_p.L4L	NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	4					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	AAAGTATTCCCAAAAGGCCCA	0.373													19	44					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133712	91133712	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chrX:91133712G>A	uc004efk.1	+	2	3318	c.2473G>A	c.(2473-2475)GTT>ATT	p.V825I	PCDH11X_uc004efl.1_Missense_Mutation_p.V825I|PCDH11X_uc004efo.1_Missense_Mutation_p.V825I|PCDH11X_uc010nmv.1_Missense_Mutation_p.V825I|PCDH11X_uc004efm.1_Missense_Mutation_p.V825I|PCDH11X_uc004efn.1_Missense_Mutation_p.V825I|PCDH11X_uc004efh.1_Missense_Mutation_p.V825I|PCDH11X_uc004efj.1_Missense_Mutation_p.V825I	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	825	Helical; (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CATAACTGTCGTTGTAGTTAT	0.463													21	13					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96053387	96053387	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr10:96053387delT	uc001kjk.2	+	23	5792	c.5158delT	c.(5158-5160)TCTfs	p.S1720fs	PLCE1_uc010qnx.1_Frame_Shift_Del_p.S1704fs|PLCE1_uc001kjm.2_Frame_Shift_Del_p.S1412fs|PLCE1_uc001kjp.2_Frame_Shift_Del_p.S78fs	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1720	Required for activation by RHOA, RHOB, GNA12, GNA13 and G-beta gamma (By similarity).				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TAACAAAACATCTGGAAAAAG	0.388													11	25	---	---	---	---					
MESP2	145873	broad.mit.edu	37	15	90320121	90320144	+	In_Frame_Del	DEL	AGGGGCAGGGGCAAGGGCAGGGGC	-	-	rs66601910		TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr15:90320121_90320144delAGGGGCAGGGGCAAGGGCAGGGGC	uc002bon.2	+	1	533_556	c.533_556delAGGGGCAGGGGCAAGGGCAGGGGC	c.(532-558)GAGGGGCAGGGGCAAGGGCAGGGGCAG>GAG	p.GQGQGQGQ195del	MESP2_uc010uqa.1_Intron	NM_001039958	NP_001035047	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog	195_202	13 X 2 AA tandem repeats of G-Q.|12.			Missing (in Ref. 2; AAI11414).	Notch signaling pathway	nucleus	DNA binding				0	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			ACGCaggcggaggggcaggggcaagggcaggggcaggggcaggg	0.473													3	4	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	G	G	rs113730440		TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr17:26684394_26684395insG	uc002haz.2	-	2	210	c.78_splice	c.e2+1	p.W26_splice	POLDIP2_uc010wag.1_RNA|TMEM199_uc002hba.2_5'Flank|SARM1_uc010wah.1_5'Flank	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2							mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													3	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	17	37200857	37200857	+	RNA	DEL	A	-	-			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr17:37200857delA	uc002hrd.1	+	4		c.2902delA								Homo sapiens cDNA FLJ43826 fis, clone TESTI4002703.																		ACTGCCAAAGAAAAAAAGGCT	0.358													2	4	---	---	---	---					
P2RX6	9127	broad.mit.edu	37	22	21380124	21380124	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr22:21380124delT	uc010gsu.1	+	9	921	c.921delT	c.(919-921)GGTfs	p.G307fs	P2RX6_uc002ztz.2_Frame_Shift_Del_p.G281fs|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	307	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						AGCAACCGGGTGTGGAGGCCC	0.657													2	4	---	---	---	---					
SEL1L3	23231	broad.mit.edu	37	4	25835187	25835188	+	Frame_Shift_Del	DEL	TA	-	-			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr4:25835187_25835188delTA	uc003gru.3	-	4	1016_1017	c.864_865delTA	c.(862-867)TTTACTfs	p.F288fs		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	288_289						integral to membrane	binding				0						AATGAAACAGTAAACCTATAAG	0.376													2	4	---	---	---	---					
RABEPK	10244	broad.mit.edu	37	9	127996226	127996226	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8110-01A-11D-2395-08	TCGA-HT-8110-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	6dbc06d4-1ab9-42f1-afd6-dd23af867c55	b325a96a-ae13-4143-a715-7e57b29f83ad	g.chr9:127996226delC	uc004bpi.2	+	9	1259	c.1086delC	c.(1084-1086)ATCfs	p.I362fs	RABEPK_uc004bpj.2_Frame_Shift_Del_p.I311fs|RABEPK_uc004bpk.2_Frame_Shift_Del_p.I362fs|RABEPK_uc004bpl.1_3'UTR|RABEPK_uc004bpm.2_Frame_Shift_Del_p.I362fs	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	362					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						AAGGGGAAATCTATGACGATT	0.388													32	90	---	---	---	---					
