Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MMEL1	79258	broad.mit.edu	37	1	2524272	2524272	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:2524272G>A	uc001ajy.2	-	20	2215	c.2001C>T	c.(1999-2001)AAC>AAT	p.N667N	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	667	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CAGCGCTCACGTTCTGTTCGT	0.637000													4	96					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2541236	2541236	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:2541236C>T	uc001ajy.2	-	5	541	c.327G>A	c.(325-327)ACG>ACA	p.T109T	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	109	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CACACGGTTCCGTGGTCGGGT	0.602000													49	86					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6202326	6202326	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:6202326G>A	uc001amb.1	-	15	2398	c.2298C>T	c.(2296-2298)CGC>CGT	p.R766R	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	766	Helicase ATP-binding.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TCTCAAACTCGCGTTCCCAGT	0.607000													69	106					0	0	1	0	0
ICMT	23463	broad.mit.edu	37	1	6285295	6285295	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:6285295C>T	uc001amk.2	-	5	773	c.700G>A	c.(700-702)GTC>ATC	p.V234I	ICMT_uc001aml.2_Missense_Mutation_p.V138I	NM_012405	NP_036537	O60725	ICMT_HUMAN	isoprenylcysteine carboxyl methyltransferase	234	Helical; (Potential).				protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;2.4e-22)|all_lung(118;2.65e-08)|Lung NSC(185;6.45e-07)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000688)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;5.52e-38)|GBM - Glioblastoma multiforme(13;6.51e-32)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;7.08e-08)|COAD - Colon adenocarcinoma(227;8.35e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		GCATAGCTGACGCCGCAGATG	0.517000													44	84					0	0	1	0	0
DNAJC11	55735	broad.mit.edu	37	1	6697342	6697342	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:6697342G>A	uc001aof.2	-	14	1546	c.1440C>T	c.(1438-1440)AGC>AGT	p.S480S	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.S428S|DNAJC11_uc010nzu.1_Silent_p.S390S	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	480					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCACCTTCTCGCTCTTCCTGC	0.567000													68	143					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8674675	8674675	+	Missense_Mutation	SNP	G	A	A	rs142313428		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:8674675G>A	uc001ape.2	-	5	1277	c.467C>T	c.(466-468)CCG>CTG	p.P156L	RERE_uc001apf.2_Missense_Mutation_p.P156L|RERE_uc001aph.1_Missense_Mutation_p.P156L	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	156	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TGATGCCACCGGCAGAGAGCA	0.488000													44	168					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15874846	15874846	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:15874846C>T	uc001aws.2	+	7	1066	c.946C>T	c.(946-948)CGG>TGG	p.R316W	DNAJC16_uc001awr.1_Missense_Mutation_p.R316W|DNAJC16_uc001awt.2_Missense_Mutation_p.R4W	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	316	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GATGACAAGGCGGTACAACAT	0.428000													34	43					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16202978	16202978	+	Missense_Mutation	SNP	G	A	A	rs139125517		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:16202978G>A	uc001axk.1	+	3	890	c.686G>A	c.(685-687)CGA>CAA	p.R229Q	SPEN_uc010obp.1_Missense_Mutation_p.R188Q	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	229	Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CGGGAGGTACGAGGCAGAAGG	0.542000													45	95					0	0	1	0	0
CROCCL1	84809	broad.mit.edu	37	1	16957459	16957459	+	RNA	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:16957459G>A	uc009vov.1	-	1		c.146C>T			CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA|CROCCL1_uc001azg.1_RNA|CROCCL1_uc001azi.1_RNA	NR_026752				Homo sapiens mRNA for FLJ00313 protein.												0						TGAGCAGGCCGGGGAGGGGCC	0.701000													4	5					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19501461	19501461	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:19501461C>T	uc001bbi.2	-	21	2844	c.2840G>A	c.(2839-2841)CGA>CAA	p.R947Q	UBR4_uc001bbm.1_Missense_Mutation_p.R158Q	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	947					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGAATCAAGTCGGTTCAAATC	0.438000													51	103					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22166340	22166340	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:22166340C>T	uc001bfj.2	-	72	9724	c.9684G>A	c.(9682-9684)ACG>ACA	p.T3228T	HSPG2_uc009vqd.2_Silent_p.T3229T	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3228	Ig-like C2-type 18.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GCAAGGTGGCCGTGTGTCCAG	0.627000													84	102					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22168798	22168798	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:22168798C>T	uc001bfj.2	-	68	9026	c.8986G>A	c.(8986-8988)GGC>AGC	p.G2996S	HSPG2_uc009vqd.2_Missense_Mutation_p.G2997S	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2996	Ig-like C2-type 15.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGGCCTGGGCCGCTGGCTGCA	0.642000													12	63					0	0	1	0	0
KDM1A	23028	broad.mit.edu	37	1	23405541	23405541	+	Silent	SNP	C	T	T	rs145299191		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:23405541C>T	uc001bgi.2	+	15	2003	c.1854C>T	c.(1852-1854)TGC>TGT	p.C618C	KDM1A_uc001bgj.2_Silent_p.C642C	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	618	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						TTTATAAATGCGACGCAGTTC	0.507000													38	204					0	0	1	0	0
HTR1D	3352	broad.mit.edu	37	1	23519885	23519885	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:23519885G>A	uc001bgn.2	-	1	1338	c.828C>T	c.(826-828)CAC>CAT	p.H276H		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	276	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	TGATTTTCACGTGGTTGAAAA	0.567000													83	103					0	0	1	0	0
EXTL1	2134	broad.mit.edu	37	1	26349416	26349416	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:26349416C>T	uc001blf.2	+	1	1146	c.279C>T	c.(277-279)GGC>GGT	p.G93G		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	93	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGCAGGGGCGATGGCCTTA	0.542000													26	128					0	0	1	0	0
TRIM63	84676	broad.mit.edu	37	1	26387782	26387782	+	Missense_Mutation	SNP	C	T	T	rs139426966		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:26387782C>T	uc001bli.1	-	3	512	c.376G>A	c.(376-378)GAA>AAA	p.E126K		NM_032588	NP_115977	Q969Q1	TRI63_HUMAN	muscle specific ring finger protein 1	126	Interaction with TTN.|B box-type.					cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTCATCTTCGTGCTCCTTG	0.582000													21	77					0	0	1	0	0
AIM1L	55057	broad.mit.edu	37	1	26650748	26650748	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:26650748C>T	uc001bmd.3	-	17	1927	c.1497G>A	c.(1495-1497)GTG>GTA	p.V499V		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	499	Ricin B-type lectin.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		CATGGTCCGGCACTGCCAGGA	0.617000													5	98					0	0	1	0	0
PHC2	1912	broad.mit.edu	37	1	33837953	33837953	+	Silent	SNP	G	A	A	rs145356735		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:33837953G>A	uc001bxg.1	-	2	324	c.270C>T	c.(268-270)ACC>ACT	p.T90T	PHC2_uc001bxh.1_Silent_p.T90T|PHC2_uc009vuh.1_Silent_p.T90T|PHC2_uc001bxi.1_Silent_p.T90T	NM_198040	NP_932157	Q8IXK0	PHC2_HUMAN	polyhomeotic-like 2 isoform a	90	Gln-rich.				multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGAGCGCCGCGGTCTGCAGCA	0.667000													41	58					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34180250	34180250	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:34180250C>T	uc001bxn.1	-	21	3252	c.3223G>A	c.(3223-3225)GCC>ACC	p.A1075T	CSMD2_uc001bxm.1_Missense_Mutation_p.A1115T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1075	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGATGCGGGCGGTGCCCTCC	0.632000													136	245					0	0	1	0	0
ZNF691	51058	broad.mit.edu	37	1	43317024	43317024	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:43317024G>A	uc001cih.2	+	2	527	c.476G>A	c.(475-477)CGG>CAG	p.R159Q	ZNF691_uc001cig.2_Missense_Mutation_p.R132Q|ZNF691_uc009vwm.2_Missense_Mutation_p.R152Q	NM_015911	NP_056995	Q5VV52	ZN691_HUMAN	zinc finger protein 691	163	C2H2-type 2.					nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CGGCACGAGCGGATCCACCTG	0.562000													40	62					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43779639	43779639	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:43779639G>A	uc001ciu.2	+	14	2488	c.2409G>A	c.(2407-2409)TCG>TCA	p.S803S	TIE1_uc010oke.1_Silent_p.S758S|TIE1_uc009vwq.2_Silent_p.S759S|TIE1_uc010okf.1_Silent_p.S448S|TIE1_uc010okg.1_Silent_p.S448S	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	803	Cytoplasmic (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGTCAGGCTCGGTCAGTGACC	0.542000													27	44					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44056971	44056971	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:44056971C>T	uc001cjr.2	+	9	1618	c.1278C>T	c.(1276-1278)AGC>AGT	p.S426S	PTPRF_uc001cjs.2_Silent_p.S426S|PTPRF_uc001cju.2_5'UTR|PTPRF_uc009vwt.2_5'UTR|PTPRF_uc001cjv.2_5'UTR	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	426	Extracellular (Potential).|Fibronectin type-III 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCATGCTGAGCGCCAGCACCA	0.726000													6	6					0	0	1	0	0
RAD54L	8438	broad.mit.edu	37	1	46739410	46739410	+	Missense_Mutation	SNP	G	A	A	rs144207599	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:46739410G>A	uc009vye.2	+	15	1715	c.1601G>A	c.(1600-1602)CGT>CAT	p.R534H	RAD54L_uc001cpl.2_Missense_Mutation_p.R534H|RAD54L_uc001cpm.1_Missense_Mutation_p.R317H	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	534	Helicase C-terminal.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		AAGCTGTGCCGTGCCCGAAGG	0.512000								Direct_reversal_of_damage|Homologous_recombination					7	13					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53925205	53925205	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:53925205G>A	uc001cvq.1	+	1	134	c.79G>A	c.(79-81)GCG>ACG	p.A27T		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	27	DM.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CAAGGGACACGCGGGCAAATG	0.612000													20	39					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55050400	55050400	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:55050400G>A	uc001cxm.1	+	2	188	c.106G>A	c.(106-108)GCA>ACA	p.A36T	ACOT11_uc001cxj.1_5'UTR|ACOT11_uc001cxk.2_Missense_Mutation_p.A2T|ACOT11_uc001cxl.1_Missense_Mutation_p.A36T	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	36	Acyl coenzyme A hydrolase 1.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						CAGTGCCATGGCAGACGGCGA	0.557000													5	130					0	0	1	0	0
DHCR24	1718	broad.mit.edu	37	1	55337128	55337128	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:55337128G>A	uc001cyc.1	-	5	900	c.771C>T	c.(769-771)CAC>CAT	p.H257H	DHCR24_uc010ooj.1_Silent_p.H119H|DHCR24_uc010ook.1_Silent_p.H216H	NM_014762	NP_055577	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase precursor	257					anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			pancreas(1)	1						GCTGGGACTCGTGGGTGAACT	0.592000													8	98					0	0	1	0	0
FAM73A	374986	broad.mit.edu	37	1	78280851	78280851	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:78280851G>A	uc001dhx.2	+	7	862	c.830G>A	c.(829-831)CGT>CAT	p.R277H	FAM73A_uc010ork.1_Missense_Mutation_p.R277H|FAM73A_uc010orl.1_Missense_Mutation_p.R239H|FAM73A_uc001dhy.1_Missense_Mutation_p.R66H	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	277						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		AGAGCCTATCGTCTCCAAGAG	0.368000													9	66					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82372829	82372829	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:82372829G>A	uc001dit.3	+	4	382	c.201G>A	c.(199-201)ACG>ACA	p.T67T	LPHN2_uc001dis.2_Silent_p.T67T|LPHN2_uc001diu.2_Silent_p.T67T|LPHN2_uc001div.2_Silent_p.T67T|LPHN2_uc009wcd.2_Silent_p.T67T	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	67	Extracellular (Potential).|SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ATGGTCGGACGGATGACAAGA	0.453000													7	215					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331490	85331490	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:85331490C>T	uc001dkl.2	-	1	353	c.314G>A	c.(313-315)CGT>CAT	p.R105H	LPAR3_uc009wcj.1_Missense_Mutation_p.R105H	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	105	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						AAGCCCCTGACGGAGAAACCA	0.502000													155	211					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91382483	91382483	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:91382483G>A	uc001dnw.2	-	6	3998	c.3856C>T	c.(3856-3858)CGA>TGA	p.R1286*	ZNF644_uc001dnv.2_Nonsense_Mutation_p.R64*|ZNF644_uc001dnx.2_Nonsense_Mutation_p.R64*	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	1286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		ACAATATGTCGTTGTAAGTGC	0.423000													27	50					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94512531	94512531	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:94512531G>A	uc001dqh.2	-	19	2966	c.2862C>T	c.(2860-2862)TAC>TAT	p.Y954Y	ABCA4_uc010otn.1_Silent_p.Y880Y	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	954	Cytoplasmic.|ABC transporter 1.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCTGGTTCTCGTAGAAGGTGA	0.552000													123	186					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94574157	94574157	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:94574157G>A	uc001dqh.2	-	4	522	c.418C>T	c.(418-420)CGG>TGG	p.R140W	ABCA4_uc010otn.1_Missense_Mutation_p.R140W	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	140	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGGTGAGTCCGGAGGGTGTCC	0.423000													6	150					0	0	1	0	0
ALG14	199857	broad.mit.edu	37	1	95492780	95492780	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:95492780G>A	uc001dra.2	-	3	378	c.325C>T	c.(325-327)CGG>TGG	p.R109W		NM_144988	NP_659425	Q96F25	ALG14_HUMAN	asparagine-linked glycosylation 14 homolog	109	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity				0		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.0615)|Epithelial(280;0.139)		TGAACCTCCCGGCTTCTTGGA	0.453000													31	57					0	0	1	0	0
CCDC76	54482	broad.mit.edu	37	1	100606421	100606421	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:100606421G>A	uc001dsv.2	+	7	534	c.515G>A	c.(514-516)GGT>GAT	p.G172D	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.G172D	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	172					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		TCTATTTTAGGTAACATTGAA	0.338000													17	46					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109801232	109801232	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:109801232C>T	uc001dxa.3	+	2	3550	c.3489C>T	c.(3487-3489)CAC>CAT	p.H1163H		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1163	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CACCGGACCACGTGGTGGTCT	0.637000													7	13					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111857960	111857960	+	Missense_Mutation	SNP	G	A	A	rs140031055		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:111857960G>A	uc001eas.2	+	6	486	c.383G>A	c.(382-384)CGC>CAC	p.R128H	CHIA_uc001ear.2_Missense_Mutation_p.R20H|CHIA_uc001eaq.2_Missense_Mutation_p.R20H|CHIA_uc009wgc.2_Missense_Mutation_p.R20H|CHIA_uc001eat.2_Intron|CHIA_uc001eav.2_5'UTR|CHIA_uc001eau.2_Intron|CHIA_uc009wgd.2_Intron	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	128					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		AAATTCCTGCGCCAGTATGAG	0.547000													86	165					0	0	1	0	0
FAM46C	54855	broad.mit.edu	37	1	118166435	118166435	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:118166435C>T	uc001ehe.2	+	2	1144	c.945C>T	c.(943-945)AAC>AAT	p.N315N		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	315											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		GGGTGGTGAACGAGAGCACCG	0.527000										Multiple Myeloma(3;1.13e-06)			45	62					0	0	1	0	0
ITGA10	8515	broad.mit.edu	37	1	145534934	145534934	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:145534934C>T	uc001eoa.2	+	15	1913	c.1837C>T	c.(1837-1839)CGA>TGA	p.R613*	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Nonsense_Mutation_p.R482*|ITGA10_uc009wiw.2_Nonsense_Mutation_p.R470*|ITGA10_uc010oyw.1_Nonsense_Mutation_p.R558*	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	613	Extracellular (Potential).|FG-GAP 7.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTACTTTGGCCGAAGTGTGGA	0.582000													39	194					0	0	1	0	0
ANXA9	8416	broad.mit.edu	37	1	150967084	150967084	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:150967084G>A	uc001ewa.2	+	13	1354	c.884G>A	c.(883-885)CGC>CAC	p.R295H		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	295	Annexin 4.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTCCTGATTCGCATCCTTATC	0.468000													117	201					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151105813	151105813	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:151105813C>T	uc001ewu.2	-	19	2240	c.1940G>A	c.(1939-1941)CGC>CAC	p.R647H	SEMA6C_uc001ewv.2_Missense_Mutation_p.R679H|SEMA6C_uc001eww.2_Missense_Mutation_p.R639H|SEMA6C_uc010pcq.1_Intron	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	647	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGAGAGAGGGCGCGGGAGCCC	0.726000													11	25					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151261051	151261051	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:151261051C>T	uc001exq.2	+	3	2261	c.2163C>T	c.(2161-2163)AGC>AGT	p.S721S	ZNF687_uc009wmo.2_Silent_p.S721S|ZNF687_uc009wmp.2_Silent_p.S721S	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	721	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCAGCTTCAGCGCCCACCAGC	0.572000													52	116					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282395	152282395	+	Missense_Mutation	SNP	C	T	T	rs139975241		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:152282395C>T	uc001ezu.1	-	3	5003	c.4967G>A	c.(4966-4968)CGT>CAT	p.R1656H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1656	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTGCATGACGAGTGCCTGA	0.567000									Ichthyosis				236	448					0	0	1	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153276410	153276410	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:153276410G>A	uc001fbn.1	-	4	505	c.452C>T	c.(451-453)TCG>TTG	p.S151L		NM_052891	NP_443123	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3 precursor	151					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATACCTGGGCGACAGGTGACC	0.552000													55	58					0	0	1	0	0
C1orf66	51093	broad.mit.edu	37	1	156702140	156702140	+	Missense_Mutation	SNP	C	T	T	rs147288369		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:156702140C>T	uc001fpu.2	+	3	938	c.304C>T	c.(304-306)CGG>TGG	p.R102W	C1orf66_uc001fpv.2_Missense_Mutation_p.R102W	NM_015997	NP_057081	Q96FB5	RRNAD_HUMAN	hypothetical protein LOC51093 isoform 1	102						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGCCTTTACCCGGATGCCTGG	0.592000													45	89					0	0	1	0	0
Unknown	0	broad.mit.edu	37	1	157895827	157895827	+	RNA	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:157895827G>A	uc001frl.1	+	1		c.64G>A								Homo sapiens cDNA FLJ32876 fis, clone TESTI2004073.																		TGGCACTCACGGTCACAGGTG	0.557000													11	18					0	0	1	0	0
SLAMF8	56833	broad.mit.edu	37	1	159802792	159802792	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:159802792G>A	uc001fue.3	+	3	704	c.494G>A	c.(493-495)CGA>CAA	p.R165Q		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	165	Ig-like C2-type.|Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					TATAGCTGGCGACGGGAGACA	0.542000													26	143					0	0	1	0	0
C1orf114	57821	broad.mit.edu	37	1	169364358	169364358	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:169364358C>T	uc001gga.1	-	6	1625	c.1457G>A	c.(1456-1458)CGT>CAT	p.R486H	BLZF1_uc001gfy.2_Intron|C1orf114_uc001gfz.1_Missense_Mutation_p.R485H|C1orf114_uc009wvq.1_Missense_Mutation_p.R485H	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	486											0	all_hematologic(923;0.208)					CTGTTTAGAACGCTTAGCTTC	0.398000													39	58					0	0	1	0	0
SLC9A11	284525	broad.mit.edu	37	1	173551052	173551052	+	Missense_Mutation	SNP	C	T	T	rs4916373		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:173551052C>T	uc001giz.2	-	7	1159	c.736G>A	c.(736-738)GTT>ATT	p.V246I	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	246					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TTGCTAAAAACGTCAGCCAAT	0.323000													26	30					0	0	1	0	0
DARS2	55157	broad.mit.edu	37	1	173826739	173826739	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:173826739G>A	uc001gjh.1	+	17	2244	c.1834G>A	c.(1834-1836)GAC>AAC	p.D612N		NM_018122	NP_060592	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	612					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			central_nervous_system(2)	2					L-Aspartic Acid(DB00128)	CCGGGGACATGACCTCATGAG	0.483000													31	122					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175097740	175097740	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:175097740G>A	uc001gkl.1	+	15	3301	c.3188G>A	c.(3187-3189)CGT>CAT	p.R1063H		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1063	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GTTGGTGCCCGTTTCCCACAC	0.527000													37	141					0	0	1	0	0
SOAT1	6646	broad.mit.edu	37	1	179310292	179310292	+	Silent	SNP	C	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:179310292C>G	uc001gml.2	+	7	690	c.627C>G	c.(625-627)GGC>GGG	p.G209G	SOAT1_uc010pni.1_Silent_p.G144G|SOAT1_uc001gmm.2_Silent_p.G151G|SOAT1_uc010pnj.1_5'UTR|SOAT1_uc010pnk.1_Silent_p.G144G	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	209					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	GGGCCACTGGCTATAGCAAGA	0.428000													98	183					0	0	1	0	0
PTGS2	5743	broad.mit.edu	37	1	186645692	186645692	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:186645692G>A	uc001gsb.2	-	7	1014	c.877C>T	c.(877-879)CGG>TGG	p.R293W	PTGS2_uc009wyo.2_Missense_Mutation_p.R140W	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	293					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	TTGTGTTCCCGCAGCCAGATT	0.507000													70	95					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198671623	198671623	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:198671623C>T	uc001gur.1	+	6	721	c.541C>T	c.(541-543)CGC>TGC	p.R181C	PTPRC_uc001gus.1_Intron|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Intron|PTPRC_uc009wzf.1_Intron|PTPRC_uc010ppg.1_Missense_Mutation_p.R117C|PTPRC_uc001guu.1_Missense_Mutation_p.R224C|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_Intron	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	181	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CTTACCTGCACGCACCTCCAA	0.498000													125	247					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201184276	201184276	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:201184276G>A	uc001gwc.2	+	3	1241	c.469G>A	c.(469-471)GTC>ATC	p.V157I	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CACCCTGACCGTCCAGGGTAA	0.458000													26	37					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201757608	201757608	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:201757608C>T	uc001gwu.2	+	10	3355	c.3008C>T	c.(3007-3009)GCG>GTG	p.A1003V	NAV1_uc001gwv.1_Missense_Mutation_p.A511V|NAV1_uc001gww.1_Missense_Mutation_p.A612V|NAV1_uc001gwx.2_Missense_Mutation_p.A612V|NAV1_uc001gwy.1_Missense_Mutation_p.A384V	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1003					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						AGTCCCACTGCGGCCACCACG	0.463000													12	202					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201982319	201982319	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:201982319G>A	uc001gxg.3	+	6	3890	c.698G>A	c.(697-699)CGT>CAT	p.R233H	ELF3_uc001gxi.3_Missense_Mutation_p.R233H|ELF3_uc001gxh.3_Missense_Mutation_p.R233H	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	233					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						GATGGTTTTCGTGACTGCAAG	0.597000													44	58					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202914187	202914187	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:202914187C>T	uc001gyq.3	-	5	808	c.541G>A	c.(541-543)GTG>ATG	p.V181M	ADIPOR1_uc010pqd.1_Missense_Mutation_p.V105M|ADIPOR1_uc001gyr.3_Intron|ADIPOR1_uc001gys.3_Missense_Mutation_p.V181M	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	181	Helical; Name=2; (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			AGGCAGAGCACTGCACCCAAA	0.448000													52	77					0	0	1	0	0
FMOD	2331	broad.mit.edu	37	1	203311549	203311549	+	Silent	SNP	G	A	A	rs142981560	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:203311549G>A	uc001gzr.2	-	3	1189	c.1053C>T	c.(1051-1053)GAC>GAT	p.D351D	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	351	LRR 11.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			TCTCGTTCCCGTCCAGGCGCA	0.642000											OREG0014119	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	50					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205138721	205138721	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:205138721G>A	uc001hbw.2	-	3	958	c.894C>T	c.(892-894)AGC>AGT	p.S298S	DSTYK_uc001hbx.2_Silent_p.S298S|DSTYK_uc001hby.1_Intron	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	298						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						GTGATCTTTCGCTCTCCATTC	0.483000													16	75					0	0	1	0	0
RAB7L1	8934	broad.mit.edu	37	1	205740772	205740772	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:205740772C>T	uc001hdf.3	-	4	546	c.206G>A	c.(205-207)CGC>CAC	p.R69H	RAB7L1_uc009xbp.2_5'UTR|RAB7L1_uc001hde.3_Missense_Mutation_p.R69H|RAB7L1_uc010prr.1_Missense_Mutation_p.R45H|RAB7L1_uc009xbq.2_Intron	NM_003929	NP_003920	O14966	RAB7L_HUMAN	RAB7, member RAS oncogene family-like 1 isoform	69					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)	1	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			AGAGGTGAAGCGCTCCTGCCC	0.498000													62	91					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207793265	207793265	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:207793265G>A	uc001hfy.2	+	35	5897	c.5757G>A	c.(5755-5757)TCG>TCA	p.S1919S	CR1_uc001hfx.2_Silent_p.S2369S	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1919	Sushi 30.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						ATGGAATCTCGAAGGAGTTAG	0.363000													6	14					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207793369	207793369	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:207793369C>T	uc001hfy.2	+	35	6001	c.5861C>T	c.(5860-5862)GCG>GTG	p.A1954V	CR1_uc001hfx.2_Missense_Mutation_p.A2404V	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1954	Sushi 30.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						CAGTGCCAGGCGGATGACAGA	0.468000											OREG0014194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	34					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220791991	220791991	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:220791991G>A	uc001hmn.3	+	9	1400	c.803G>A	c.(802-804)CGA>CAA	p.R268Q	MARK1_uc009xdw.2_Missense_Mutation_p.R268Q|MARK1_uc010pun.1_Missense_Mutation_p.R268Q|MARK1_uc001hmm.3_Missense_Mutation_p.R246Q	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	268	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		CTGCGAGAGCGAGTTTTACGA	0.353000													31	72					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227261695	227261695	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:227261695G>A	uc001hqr.2	-	19	3548	c.2605C>T	c.(2605-2607)CGT>TGT	p.R869C	CDC42BPA_uc001hqq.2_Missense_Mutation_p.R133C|CDC42BPA_uc001hqs.2_Missense_Mutation_p.R788C|CDC42BPA_uc009xes.2_Missense_Mutation_p.R869C|CDC42BPA_uc010pvs.1_Missense_Mutation_p.R869C|CDC42BPA_uc001hqp.2_Missense_Mutation_p.R25C|CDC42BPA_uc001hqu.1_Missense_Mutation_p.R25C	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	869					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				GCAAAACGACGCATTTTCCAG	0.378000													9	239					0	0	1	0	0
C1orf69	200205	broad.mit.edu	37	1	228362946	228362946	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:228362946G>A	uc001hsl.3	+	3	892	c.803G>A	c.(802-804)CGC>CAC	p.R268H	C1orf69_uc010pvw.1_Missense_Mutation_p.R75H	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	268					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CTGACGGCCCGCACCCACCAC	0.647000													24	168					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228471282	228471282	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:228471282C>T	uc009xez.1	+	33	8860	c.8816C>T	c.(8815-8817)ACG>ATG	p.T2939M	OBSCN_uc001hsn.2_Missense_Mutation_p.T2939M|OBSCN_uc001hsp.1_Missense_Mutation_p.T638M|OBSCN_uc001hsq.1_Missense_Mutation_p.T195M	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2939	Ig-like 29.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACGTGCAAGACGGAGCACCCC	0.632000													30	53					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232574983	232574983	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:232574983G>A	uc001hvg.2	-	13	4060	c.3902C>T	c.(3901-3903)GCC>GTC	p.A1301V	SIPA1L2_uc001hvf.2_Missense_Mutation_p.A375V	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1301					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AGAGACGTCGGCAGCATCAGC	0.667000													12	137					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233497841	233497841	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:233497841C>G	uc001hvt.3	+	5	1615	c.1354C>G	c.(1354-1356)CAG>GAG	p.Q452E	KIAA1804_uc001hvs.1_Missense_Mutation_p.Q452E	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	452					activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				GGCGGCTCTGCAGCAGAAGTC	0.582000													3	49					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245848743	245848743	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:245848743G>A	uc001ibf.1	+	12	2898	c.2458G>A	c.(2458-2460)GAA>AAA	p.E820K	KIF26B_uc001ibg.1_Missense_Mutation_p.E438K|KIF26B_uc001ibh.1_Missense_Mutation_p.E62K	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	820					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GAGCTCCTGCGAAGAAGGCCG	0.652000													18	36					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247021040	247021040	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:247021040C>T	uc001ibu.1	-	29	4216	c.4209G>A	c.(4207-4209)CCG>CCA	p.P1403P	AHCTF1_uc001ibv.1_Silent_p.P1412P|AHCTF1_uc009xgs.1_Silent_p.P264P|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1403	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTCCTTGAACCGGGCTTAAGT	0.343000													4	69					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7618615	7618615	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:7618615G>A	uc001ijq.2	-	10	1858	c.1779C>T	c.(1777-1779)GAC>GAT	p.D593D	ITIH5_uc001ijp.2_Silent_p.D379D|ITIH5_uc001ijr.1_Silent_p.D593D	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	593					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CCGGTTCATCGTCACTTTGCA	0.647000													4	82					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12142226	12142226	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:12142226C>T	uc001ild.3	+	9	1820	c.1721C>T	c.(1720-1722)GCG>GTG	p.A574V		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	574					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			TGGGCCACCGCGGAAGCTCTT	0.318000													47	173					0	0	1	0	0
MKX	283078	broad.mit.edu	37	10	28023587	28023587	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:28023587G>A	uc001ity.3	-	5	861	c.636C>T	c.(634-636)TAC>TAT	p.Y212Y	MKX_uc001itx.3_Silent_p.Y212Y	NM_173576	NP_775847	Q8IYA7	MKX_HUMAN	mohawk homeobox	212					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGGGTGCCACGTAGTCCTCAC	0.488000													88	59					0	0	1	0	0
Unknown	0	broad.mit.edu	37	10	30984970	30984970	+	Translation_Start_Site	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:30984970G>A	uc010qdx.1	+	2	144	c.-398G>A	c.(-400--396)CCGTG>CCATG							SubName: Full=cDNA FLJ59642, highly similar to Supervillin;																		CAACAGCGCCGTGCCCTTCAA	0.542000													3	17					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49687793	49687793	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:49687793G>A	uc001jgt.2	-	4	634	c.337C>T	c.(337-339)CGG>TGG	p.R113W	ARHGAP22_uc001jgs.2_Missense_Mutation_p.R23W|ARHGAP22_uc001jgu.2_Missense_Mutation_p.R113W|ARHGAP22_uc010qgl.1_Intron|ARHGAP22_uc010qgm.1_Missense_Mutation_p.R119W|ARHGAP22_uc001jgv.2_5'UTR|uc001jgw.2_5'Flank	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	113	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						ACCTTCTCCCGCTCCCCGGCA	0.672000													9	20					0	0	1	0	0
STOX1	219736	broad.mit.edu	37	10	70645798	70645798	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:70645798G>A	uc001jos.2	+	3	2333	c.2246G>A	c.(2245-2247)CGT>CAT	p.R749H	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.R639H	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	749						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						GACGACTTACGTCAAATGCTG	0.438000													28	78					0	0	1	0	0
TSPAN15	23555	broad.mit.edu	37	10	71258152	71258152	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:71258152G>A	uc001jpo.1	+	5	695	c.570G>A	c.(568-570)ACG>ACA	p.T190T		NM_012339	NP_036471	O95858	TSN15_HUMAN	transmembrane 4 superfamily member 15	190	Extracellular (Potential).					integral to plasma membrane|membrane fraction					0						TCAGGAACACGGTAGACACTG	0.587000													29	43					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73461953	73461953	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:73461953G>A	uc001jrx.3	+	22	2949	c.2572G>A	c.(2572-2574)GTC>ATC	p.V858I	CDH23_uc001jry.2_Missense_Mutation_p.V474I|CDH23_uc001jrz.2_Missense_Mutation_p.V474I	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	858	Cadherin 8.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CAAAATCGTCGTCTCTGTTAC	0.657000													40	178					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	80968196	80968196	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:80968196G>A	uc001kaf.2	+	6	736	c.164G>A	c.(163-165)GGC>GAC	p.G55D	ZMIZ1_uc001kae.2_Missense_Mutation_p.G55D	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	55					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGCCTGATGGGCTGTTTGACG	0.607000													4	71					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95095762	95095762	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:95095762G>A	uc001kin.2	-	41	4602	c.4479C>T	c.(4477-4479)GGC>GGT	p.G1493G	MYOF_uc001kio.2_Silent_p.G1480G|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1493	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						AGTCTGTCAGGCCCTCAAATT	0.373000													7	148					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96480238	96480238	+	Translation_Start_Site	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:96480238C>T	uc010qny.1	+	4	574	c.-284C>T	c.(-286--282)AACGA>AATGA		CYP2C18_uc001kjv.3_Missense_Mutation_p.T302M|CYP2C18_uc001kjw.3_Missense_Mutation_p.T243M|CYP2C19_uc009xus.1_Intron	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,						exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	ACAGAGACAACGAGCACCACT	0.418000													19	78					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98064310	98064310	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:98064310C>T	uc001kmf.2	+	1	226	c.56C>T	c.(55-57)ACG>ATG	p.T19M	DNTT_uc001kmg.2_Missense_Mutation_p.T19M	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	19					DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		CCCCGGCAGACGGGTGCCTTG	0.567000													21	84					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99696063	99696063	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:99696063G>A	uc001kou.1	-	3	641	c.285C>T	c.(283-285)ATC>ATT	p.I95I	CRTAC1_uc001kov.2_Silent_p.I84I|CRTAC1_uc001kot.1_5'UTR	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	95						proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CATCGACCGCGATGTTCACCA	0.667000													31	40					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104141973	104141973	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:104141973C>T	uc001kux.1	+	40	5700	c.5460C>T	c.(5458-5460)GGC>GGT	p.G1820G	GBF1_uc001kuy.1_Silent_p.G1816G|GBF1_uc001kuz.1_Silent_p.G1817G	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1820	Pro-rich.				COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		TGCAGGTGGGCGTGCCACCTA	0.682000													50	158					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105184818	105184818	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:105184818G>A	uc001kwy.1	+	20	2928	c.2841G>A	c.(2839-2841)ACG>ACA	p.T947T		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	947					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TGGTAGAGACGGGCCACCTGG	0.547000													25	102					0	0	1	0	0
CALHM2	51063	broad.mit.edu	37	10	105209166	105209166	+	Missense_Mutation	SNP	C	T	T	rs139579411		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:105209166C>T	uc001kwz.2	-	2	919	c.533G>A	c.(532-534)CGC>CAC	p.R178H	CALHM2_uc001kxa.2_Missense_Mutation_p.R178H|CALHM2_uc001kxc.2_Missense_Mutation_p.R178H|CALHM2_uc001kxb.2_Missense_Mutation_p.R178H|CALHM2_uc001kxd.1_Missense_Mutation_p.R178H	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	178						integral to membrane				skin(1)	1						CCTGAGCCTGCGGCTGACCTC	0.592000													33	123					0	0	1	0	0
C10orf78	119392	broad.mit.edu	37	10	105883598	105883598	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:105883598G>A	uc001kxu.2	+	3	275	c.262G>A	c.(262-264)GCA>ACA	p.A88T	C10orf78_uc001kxs.2_Missense_Mutation_p.A75T|C10orf78_uc001kxt.2_Missense_Mutation_p.A42T|C10orf78_uc001kxv.2_Missense_Mutation_p.A150T	NM_001002759	NP_001002759	Q86XK3	SFR1_HUMAN	hypothetical protein LOC119392 isoform a	88					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;1.31e-09)|all cancers(201;3.84e-08)|BRCA - Breast invasive adenocarcinoma(275;0.014)		AGAGAAACCAGCATCTTCCAC	0.299000													8	79					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120796752	120796752	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:120796752G>A	uc001ldu.2	-	21	3944	c.3798C>T	c.(3796-3798)GAC>GAT	p.D1266D	EIF3A_uc010qsu.1_Silent_p.D1232D	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	1266	Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TATCCCTATCGTCCCGGCGAC	0.547000													36	136					0	0	1	0	0
GPR26	2849	broad.mit.edu	37	10	125426287	125426287	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:125426287G>A	uc001lhh.2	+	1	417	c.364G>A	c.(364-366)GAC>AAC	p.D122N		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	122	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				GCGCCTCCGCGACGCGGCGCT	0.701000													8	16					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125804256	125804256	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:125804256G>A	uc001lhl.2	-	2	1239	c.726C>T	c.(724-726)CAC>CAT	p.H242H	CHST15_uc001lhm.2_Silent_p.H242H|CHST15_uc001lhn.2_Silent_p.H242H|CHST15_uc010que.1_Silent_p.H242H|CHST15_uc001lho.2_Silent_p.H242H	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	242	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						TCCCGTGCGCGTGCGCCAGGT	0.662000													15	25					0	0	1	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135101799	135101799	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:135101799T>C	uc001lmg.1	-	11	1913	c.1556A>G	c.(1555-1557)TAC>TGC	p.Y519C	TUBGCP2_uc001lmf.1_Missense_Mutation_p.Y112C|TUBGCP2_uc010qvc.1_Missense_Mutation_p.Y547C|TUBGCP2_uc009ybk.1_Missense_Mutation_p.Y519C|TUBGCP2_uc010qvd.1_Missense_Mutation_p.Y389C|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	519					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		CATGAGGAAGTAGCGCTTGAT	0.682000													15	53					0	0	1	0	0
DEAF1	10522	broad.mit.edu	37	11	654033	654033	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:654033C>T	uc001lqq.1	-	11	2215	c.1522G>A	c.(1522-1524)GGC>AGC	p.G508S	DEAF1_uc009ycf.1_RNA	NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	508	MYND-type.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GCCTCCCGGCCGCAGTTAACG	0.622000													12	53					0	0	1	0	0
LRDD	55367	broad.mit.edu	37	11	800359	800359	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:800359G>A	uc001lro.1	-	13	2276	c.2134C>T	c.(2134-2136)CGG>TGG	p.R712W	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_Intron|LRDD_uc001lrk.1_Intron|LRDD_uc001lrl.1_Missense_Mutation_p.R555W|LRDD_uc001lrm.1_Missense_Mutation_p.R399W|LRDD_uc001lrn.1_Missense_Mutation_p.R555W|LRDD_uc001lrp.1_Intron	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	712					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGAGCCTCCCGGTCCAGAGTG	0.632000													36	81					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1080294	1080294	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:1080294C>T	uc001lsx.1	+	8	1041	c.1014C>T	c.(1012-1014)GAC>GAT	p.D338D		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	338	TIL.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCGTATATGACGACATCGGGG	0.647000													5	18					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1265465	1265465	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:1265465C>T	uc009ycr.1	+	48	9395	c.9269C>T	c.(9268-9270)ACG>ATG	p.T3090M	MUC5B_uc001ltb.2_Missense_Mutation_p.T2455M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2452	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTGGATCCACGGCCACCCCG	0.667000													35	162					0	0	1	0	0
DUSP8	1850	broad.mit.edu	37	11	1578531	1578531	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:1578531C>T	uc001lts.2	-	7	1223	c.1095G>A	c.(1093-1095)CCG>CCA	p.P365P		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	365	Tyrosine-protein phosphatase.|Pro-rich.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		CGCTGGTcgccgggggcgtgg	0.537000													6	4					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2428525	2428525	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:2428525G>A	uc001lwm.3	-	20	2951	c.2942C>T	c.(2941-2943)ACG>ATG	p.T981M	TRPM5_uc010qxl.1_Missense_Mutation_p.T981M|TRPM5_uc009ydn.2_Missense_Mutation_p.T983M	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	981	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CACCTGGAACGTGTAGCTGCA	0.642000													18	15					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4944910	4944910	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:4944910G>A	uc010qyr.1	-	1	660	c.660C>T	c.(658-660)TAC>TAT	p.Y220Y		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	220	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGATGAGGGCGTATGAGAGAA	0.547000													26	89					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5322671	5322671	+	Missense_Mutation	SNP	C	T	T	rs115916434	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:5322671C>T	uc010qza.1	-	1	506	c.506G>A	c.(505-507)CGT>CAT	p.R169H	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033179	NP_149419	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAAGAGGGCACGGGAACCACA	0.423000													52	70					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6261503	6261503	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:6261503G>A	uc001mco.2	+	4	586	c.479G>A	c.(478-480)CGC>CAC	p.R160H	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.R120H	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	160	Extracellular (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACAGAGACCCGCACAGCTTAC	0.587000													6	178					0	0	1	0	0
ST5	6764	broad.mit.edu	37	11	8752647	8752647	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:8752647G>A	uc001mgt.2	-	3	376	c.190C>T	c.(190-192)CGG>TGG	p.R64W	ST5_uc009yfr.2_Intron|ST5_uc001mgu.2_Intron|ST5_uc001mgv.2_Missense_Mutation_p.R64W|ST5_uc010rbq.1_Intron|ST5_uc001mgw.1_Missense_Mutation_p.R64W	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	64	Pro-rich.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		AGGAGCACCCGGGAGCTGGAG	0.612000													6	61					0	0	1	0	0
ZNF143	7702	broad.mit.edu	37	11	9522711	9522711	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:9522711C>T	uc001mhr.2	+	11	1159	c.1041C>T	c.(1039-1041)CAC>CAT	p.H347H	ZNF143_uc009yfu.2_Silent_p.H346H|ZNF143_uc010rby.1_Silent_p.H316H	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	347	C2H2-type 4.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		GAAAAGTGCACGTTAGGACAC	0.433000													55	115					0	0	1	0	0
INSC	387755	broad.mit.edu	37	11	15197574	15197574	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:15197574G>A	uc001mly.2	+	3	531	c.485G>A	c.(484-486)CGC>CAC	p.R162H	INSC_uc001mlz.2_Missense_Mutation_p.R115H|INSC_uc001mma.2_Missense_Mutation_p.R115H|INSC_uc010rcs.1_Missense_Mutation_p.R115H|INSC_uc001mmb.2_Missense_Mutation_p.R115H|INSC_uc001mmc.2_Missense_Mutation_p.R115H	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	162					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TGCCATGCCCGCTCCATGGTC	0.622000													6	10					0	0	1	0	0
TSG101	7251	broad.mit.edu	37	11	18503252	18503252	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:18503252G>A	uc001mor.2	-	9	1134	c.1008C>T	c.(1006-1008)AAC>AAT	p.N336N		NM_006292	NP_006283	Q99816	TS101_HUMAN	tumor susceptibility gene 101	336	SB.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0						CTTCAATAGCGTTTTCTTCTG	0.388000													36	58					0	0	1	0	0
TMEM86A	144110	broad.mit.edu	37	11	18723160	18723160	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:18723160G>A	uc001moz.1	+	3	410	c.327G>A	c.(325-327)TCG>TCA	p.S109S		NM_153347	NP_699178	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	109	Helical; (Potential).					integral to membrane				ovary(1)	1						TCTACGCCTCGGCCTTTGGCA	0.587000													92	91					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31805009	31805009	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:31805009C>T	uc001mtb.2	+	10	1247	c.1212C>T	c.(1210-1212)TCC>TCT	p.S404S	ELP4_uc001mtc.2_3'UTR|ELP4_uc010rdz.1_Missense_Mutation_p.R452C	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	404					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					TGGCAGAATCCGCCAAGCGGC	0.522000													42	125					0	0	1	0	0
CSTF3	1479	broad.mit.edu	37	11	33120307	33120307	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:33120307G>A	uc001muh.2	-	13	1223	c.1057C>T	c.(1057-1059)CGC>TGC	p.R353C	TCP11L1_uc001muf.1_Intron	NM_001326	NP_001317	Q12996	CSTF3_HUMAN	cleavage stimulation factor subunit 3 isoform 1	353					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding				0						TACTTCATGCGACTCTAAGGT	0.393000													28	112					0	0	1	0	0
C11orf41	25758	broad.mit.edu	37	11	33604946	33604946	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:33604946G>A	uc001mup.3	+	10	3716	c.3592G>A	c.(3592-3594)GTG>ATG	p.V1198M	C11orf41_uc001mun.1_Missense_Mutation_p.V1198M	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1192	Helical; (Potential).					integral to membrane				ovary(2)	2						GCCCATTGCCGTGGTCACGGT	0.547000													9	11					0	0	1	0	0
EXT2	2132	broad.mit.edu	37	11	44255740	44255740	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:44255740G>C	uc001mxz.2	+	12	2216	c.1882G>C	c.(1882-1884)GAT>CAT	p.D628H	EXT2_uc010rfo.1_Missense_Mutation_p.D656H|EXT2_uc001mxy.2_Missense_Mutation_p.D641H|EXT2_uc009ykt.2_Missense_Mutation_p.D638H|EXT2_uc001mya.2_Missense_Mutation_p.D661H	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	628	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						GAACTGTGAAGATATTGCCAT	0.333000			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				17	41					0	0	1	0	0
TCN1	6947	broad.mit.edu	37	11	59623424	59623424	+	Silent	SNP	G	A	A	rs72550759	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:59623424G>A	uc001noj.2	-	6	953	c.855C>T	c.(853-855)AAC>AAT	p.N285N		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	285					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGGCTGCAGCGTTTGGATTGC	0.413000													5	126					0	0	1	0	0
INCENP	3619	broad.mit.edu	37	11	61912746	61912746	+	Silent	SNP	C	T	T	rs141016037		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:61912746C>T	uc001nsw.1	+	13	2023	c.1821C>T	c.(1819-1821)GAC>GAT	p.D607D	INCENP_uc009ynw.1_Silent_p.D607D|INCENP_uc001nsx.1_Silent_p.D603D|INCENP_uc001nsy.1_Silent_p.D17D	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	607	Potential.				chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						CTCAGATCGACGAGAAGACTG	0.577000													9	131					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62397318	62397318	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:62397318G>A	uc001nub.2	-	14	1738	c.1705C>T	c.(1705-1707)CGG>TGG	p.R569W	GANAB_uc001ntz.2_5'Flank|GANAB_uc001nua.2_Missense_Mutation_p.R591W|GANAB_uc001nuc.2_Missense_Mutation_p.R472W|GANAB_uc010rma.1_Missense_Mutation_p.R477W|GANAB_uc010rmb.1_Missense_Mutation_p.R455W	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	569					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						TGCACATCCCGGTGCTCCCAG	0.522000													5	120					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64506852	64506852	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:64506852C>T	uc009ypu.2	-	8	1020	c.793G>A	c.(793-795)GTT>ATT	p.V265I	RASGRP2_uc001oat.2_Missense_Mutation_p.V167I|RASGRP2_uc001oau.2_Missense_Mutation_p.V120I|RASGRP2_uc009ypv.2_Missense_Mutation_p.V265I|RASGRP2_uc009ypw.2_Missense_Mutation_p.V265I	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	265	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						TCAGGGCTAACGTGGCTGTGG	0.458000													11	66					0	0	1	0	0
C11orf2	738	broad.mit.edu	37	11	64875676	64875676	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:64875676G>A	uc001ocr.1	+	5	773	c.733G>A	c.(733-735)GGC>AGC	p.G245S	C11orf2_uc001ocs.1_Missense_Mutation_p.G121S	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	245					lipid transport|protein transport	Golgi apparatus|integral to membrane					0						CAGGGAGGGCGGCTCAGGCGC	0.716000													5	17					0	0	1	0	0
EFEMP2	30008	broad.mit.edu	37	11	65635366	65635366	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:65635366C>T	uc001ofy.3	-	10	1330	c.1136G>A	c.(1135-1137)CGT>CAT	p.R379H	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.R379H	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	379					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GTTTCCAGCACGGATCTGAAA	0.552000													40	132					0	0	1	0	0
PELI3	246330	broad.mit.edu	37	11	66243521	66243521	+	Silent	SNP	C	A	A	rs139368303		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:66243521C>A	uc001oic.3	+	8	1457	c.1293C>A	c.(1291-1293)GCC>GCA	p.A431A	PELI3_uc001oid.3_Silent_p.A407A|PELI3_uc001oie.3_Silent_p.A282A	NM_145065	NP_659502	Q8N2H9	PELI3_HUMAN	pellino 3 alpha isoform 1	431						cytosol	protein binding			ovary(1)	1						GCTACTGGGCCCAGACACCAC	0.672000													10	18					2.17888e-05	2.20157e-05	1	1	0
BBS1	582	broad.mit.edu	37	11	66297334	66297334	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:66297334C>T	uc001oij.1	+	14	1396	c.1384C>T	c.(1384-1386)CGT>TGT	p.R462C	BBS1_uc001oii.1_Missense_Mutation_p.R499C|BBS1_uc010rpg.1_Missense_Mutation_p.R365C|BBS1_uc001oik.1_Missense_Mutation_p.R386C|BBS1_uc001oil.1_Missense_Mutation_p.R333C|ZDHHC24_uc001oim.1_Intron|ZDHHC24_uc009yrg.1_Intron|BBS1_uc010rph.1_Missense_Mutation_p.R130C	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	462					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						GCTGCGCCTACGTGCTGCCCG	0.677000									Bardet-Biedl_syndrome				30	44					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66460877	66460877	+	Missense_Mutation	SNP	G	A	A	rs150801133	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:66460877G>A	uc001ojd.2	-	23	4706	c.4634C>T	c.(4633-4635)GCG>GTG	p.A1545V		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1545	Spectrin 12.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCTCAGGTCCGCGATCCGGGG	0.627000													9	35					0	0	1	0	0
KDM2A	22992	broad.mit.edu	37	11	67012792	67012792	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:67012792C>T	uc001ojw.2	+	14	2560	c.1696C>T	c.(1696-1698)CGG>TGG	p.R566W	KDM2A_uc001ojx.2_RNA|KDM2A_uc001ojy.2_Missense_Mutation_p.R260W|KDM2A_uc010rpn.1_Missense_Mutation_p.R127W|KDM2A_uc001ojz.1_Missense_Mutation_p.R24W	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	566	CXXC-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						AGGAGCCAGACGGAGACGAGT	0.552000													38	86					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925272	67925272	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:67925272G>A	uc001onm.1	-	11	2797	c.2541C>T	c.(2539-2541)GAC>GAT	p.D847D	SUV420H1_uc009yse.1_Silent_p.D433D|SUV420H1_uc001onn.1_Silent_p.D675D|SUV420H1_uc009ysf.2_Silent_p.D607D	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	847					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						GAATAAAATCGTCTTCAAAGT	0.403000													39	43					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68748335	68748335	+	Missense_Mutation	SNP	C	T	T	rs144924033		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:68748335C>T	uc010rqf.1	-	1	121	c.121G>A	c.(121-123)GGG>AGG	p.G41R		NM_198923	NP_944605	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	41	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(1)	1			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCTGCCATCCCGCACAGGCAG	0.597000													53	53					0	0	1	0	0
PRCP	5547	broad.mit.edu	37	11	82550376	82550376	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:82550376G>A	uc001ozs.2	-	7	1126	c.1013C>T	c.(1012-1014)TCG>TTG	p.S338L	PRCP_uc001ozr.2_Missense_Mutation_p.S359L	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	338					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						CACCTGGCCCGAATAATTGTA	0.403000													27	103					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92568224	92568224	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:92568224G>A	uc001pdj.3	+	14	10077	c.10060G>A	c.(10060-10062)GCC>ACC	p.A3354T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3354	Extracellular (Potential).|Cadherin 31.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGTGAAGACGCCTTGGTGGG	0.483000										TCGA Ovarian(4;0.039)			3	33					0	0	1	0	0
AMOTL1	154810	broad.mit.edu	37	11	94554766	94554766	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:94554766G>A	uc001pfb.2	+	4	1362	c.1192G>A	c.(1192-1194)GCC>ACC	p.A398T	AMOTL1_uc001pfc.2_Missense_Mutation_p.A348T	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	398						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				GACCTCTTCCGCCAGCGGGCC	0.662000													18	25					0	0	1	0	0
AASDHPPT	60496	broad.mit.edu	37	11	105967614	105967614	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:105967614C>T	uc001pjc.1	+	6	1056	c.910C>T	c.(910-912)CGA>TGA	p.R304*	AASDHPPT_uc010rvn.1_RNA|AASDHPPT_uc001pjd.1_Nonsense_Mutation_p.R157*	NM_015423	NP_056238	Q9NRN7	ADPPT_HUMAN	aminoadipate-semialdehyde	304					macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding				0		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)		AATTCCAATACGAAATGGTAC	0.348000													9	29					0	0	1	0	0
PCSK7	9159	broad.mit.edu	37	11	117100140	117100140	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:117100140G>A	uc001pqr.2	-	3	622	c.421C>T	c.(421-423)CGC>TGC	p.R141C		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	141		Cleavage; by autolysis (By similarity).			peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		TGGACGCTGCGCTTGGCCCGC	0.617000			T	IGH@	MLCLS								48	170					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117352692	117352692	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:117352692C>T	uc001prh.1	-	12	2727	c.2725G>A	c.(2725-2727)GTC>ATC	p.V909I		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	849	Extracellular (Potential).|Ig-like C2-type 9.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGTGTGGAGACGACCTCGTCG	0.627000													12	96					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119029628	119029628	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:119029628G>A	uc001pvs.2	+	12	1762	c.1426G>A	c.(1426-1428)GTG>ATG	p.V476M	ABCG4_uc009zar.2_Missense_Mutation_p.V476M	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	476	ABC transmembrane type-2.|Helical; Name=3; (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CATGGCTGACGTGCCCTTTCA	0.542000													47	136					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123596990	123596990	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:123596990C>T	uc001pzd.1	-	9	2062	c.1662G>A	c.(1660-1662)GCG>GCA	p.A554A	ZNF202_uc001pzc.1_Silent_p.A330A|ZNF202_uc001pze.1_Silent_p.A554A|ZNF202_uc001pzf.1_Silent_p.A554A	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	554	C2H2-type 5.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TCTTCCGGTGCGCCAGGTACC	0.577000													61	69					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909049	123909049	+	Silent	SNP	G	A	A	rs12291067	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:123909049G>A	uc001pzq.1	-	1	660	c.660C>T	c.(658-660)ATC>ATT	p.I220I		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	220	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGGAACAGACGATGGACACAT	0.557000													31	106					0	0	1	0	0
NINJ2	4815	broad.mit.edu	37	12	674455	674455	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:674455G>A	uc001qil.2	-	3	604	c.513C>T	c.(511-513)TTC>TTT	p.F171F		NM_016533	NP_057617	Q9NZG7	NINJ2_HUMAN	ninjurin 2	125	Helical; (Potential).				nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				ovary(2)	2	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			TATGTGCCCCGAAGGCTGTAA	0.537000													9	91					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5021390	5021390	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:5021390C>T	uc001qnh.2	+	2	1951	c.846C>T	c.(844-846)GGC>GGT	p.G282G		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	282					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ACCAGAAGGGCGAGCAGGCCA	0.517000													54	94					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7310123	7310123	+	Missense_Mutation	SNP	G	A	A	rs138735435		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:7310123G>A	uc001qsr.2	+	17	2844	c.2566G>A	c.(2566-2568)GTG>ATG	p.V856M	CLSTN3_uc001qss.2_Missense_Mutation_p.V868M|CLSTN3_uc001qst.2_Missense_Mutation_p.V264M	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	856	Helical; (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						TGTGGTGTGCGTGGGCTTCCT	0.667000													32	43					0	0	1	0	0
KLRC2	3822	broad.mit.edu	37	12	10584712	10584712	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:10584712T>C	uc001qyk.2	-	5	584	c.577A>G	c.(577-579)AAA>GAA	p.K193E	KLRC3_uc001qyh.2_Intron|KLRC2_uc010she.1_Missense_Mutation_p.K193E	NM_002260	NP_002251	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C,	193	Extracellular (Potential).|C-type lectin.				cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						TACTTATGTTTGAAAGCCAAA	0.313000													12	51					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12302045	12302045	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:12302045C>T	uc001rah.3	-	14	3179	c.3037G>A	c.(3037-3039)GAA>AAA	p.E1013K	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.E1013K	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1013	LDL-receptor class B 16.|Extracellular (Potential).|Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GGTTGTATTTCCAGGTTCTGA	0.438000													147	216					0	0	1	0	0
Unknown	0	broad.mit.edu	37	12	24736338	24736338	+	RNA	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:24736338C>T	uc001rgb.1	-	1		c.765G>A								Homo sapiens cDNA FLJ32894 fis, clone TESTI2004994.																		GCACCCTTTGCGAGGGGCACG	0.557000													15	43					0	0	1	0	0
C12orf11	55726	broad.mit.edu	37	12	27069110	27069110	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:27069110C>T	uc001rhk.3	-	11	1610	c.1073G>A	c.(1072-1074)CGT>CAT	p.R358H	C12orf11_uc001rhj.3_5'UTR|C12orf11_uc010sjk.1_Missense_Mutation_p.R257H	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	358					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					TAAAACAGAACGACCTGTCAA	0.338000													16	39					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49392947	49392947	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:49392947A>G	uc001rsv.1	-	1	142	c.124T>C	c.(124-126)TCC>CCC	p.S42P	uc001rsw.2_Intron	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	42						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						TAATGACAGGAAATAGTCTTC	0.607000													27	44					0	0	1	0	0
MLL2	8085	broad.mit.edu	37	12	49422916	49422916	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:49422916A>G	uc001rta.3	-	44	14179	c.14179T>C	c.(14179-14181)TCA>CCA	p.S4727P		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4727					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CACCGGCCTGAGCCCAGATGA	0.617000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			12	59					0	0	1	0	0
MLL2	8085	broad.mit.edu	37	12	49445202	49445202	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:49445202C>T	uc001rta.3	-	10	2264	c.2264G>A	c.(2263-2265)CGG>CAG	p.R755Q		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	755	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTCCTCAGGCCGGGGGGACAG	0.687000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			42	73					0	0	1	0	0
MLL2	8085	broad.mit.edu	37	12	49445921	49445921	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:49445921C>T	uc001rta.3	-	10	1545	c.1545G>A	c.(1543-1545)CTG>CTA	p.L515L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	515	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCGACTCCTCCAGTGGAGAAA	0.617000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			38	67					0	0	1	0	0
POU6F1	5463	broad.mit.edu	37	12	51586185	51586185	+	Missense_Mutation	SNP	C	T	T	rs139629485		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:51586185C>T	uc001rxy.2	-	3	511	c.319G>A	c.(319-321)GCC>ACC	p.A107T	POU6F1_uc001rxz.2_Missense_Mutation_p.A107T|POU6F1_uc001rya.2_Missense_Mutation_p.A107T	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	107	Gln/Pro-rich.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GATGGCTTGGCGGCTGGAGCT	0.597000													83	153					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52713013	52713013	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:52713013C>T	uc001saf.2	-	2	583	c.520G>A	c.(520-522)GTG>ATG	p.V174M		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	174	Rod.|Coil 1B.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCAGCCTCCACGCACTCGGCC	0.612000													81	169					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56094110	56094110	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:56094110G>A	uc001shh.2	-	5	958	c.738C>T	c.(736-738)TAC>TAT	p.Y246Y	ITGA7_uc001shg.2_Intron|ITGA7_uc010sps.1_Silent_p.Y149Y|ITGA7_uc009znx.2_Intron	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	246	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						CCCCCGCCTCGTAGGGACCGT	0.662000													24	54					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56568511	56568511	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:56568511G>A	uc001skb.2	-	16	1526	c.1420C>T	c.(1420-1422)CGA>TGA	p.R474*	SMARCC2_uc001skd.2_Nonsense_Mutation_p.R474*|SMARCC2_uc001ska.2_Nonsense_Mutation_p.R474*|SMARCC2_uc001skc.2_Nonsense_Mutation_p.R474*|SMARCC2_uc010sqf.1_Nonsense_Mutation_p.R363*	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	474	SWIRM.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGTTCAGTCGGTAAGTGTCA	0.468000													30	166					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56815752	56815752	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:56815752C>T	uc001slf.2	-	21	2741	c.2573G>A	c.(2572-2574)CGA>CAA	p.R858Q		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	858					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CTTGCGTGTTCGAGGAACAGT	0.547000													91	110					0	0	1	0	0
MARCH9	92979	broad.mit.edu	37	12	58152527	58152527	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:58152527G>A	uc001spx.1	+	4	1300	c.888G>A	c.(886-888)ACG>ACA	p.T296T	MARCH9_uc001spy.2_Silent_p.T183T	NM_138396	NP_612405	Q86YJ5	MARH9_HUMAN	membrane-associated RING-CH protein IX	296						Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding				0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CTGGGGCCACGAGCCGCCCCC	0.652000													10	26					0	0	1	0	0
USP15	9958	broad.mit.edu	37	12	62715345	62715345	+	Silent	SNP	T	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:62715345T>C	uc001src.1	+	5	585	c.576T>C	c.(574-576)AAT>AAC	p.N192N	USP15_uc001srb.1_Silent_p.N192N|USP15_uc001sra.2_Silent_p.N192N	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	192					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		AACCACTGAATAAACCAGACA	0.333000													24	33					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64811871	64811871	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:64811871G>A	uc001ssb.2	+	5	672	c.246G>A	c.(244-246)ACG>ACA	p.T82T	XPOT_uc009zqm.1_Intron	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	82	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		TTAGGGAGACGCTCATATCAT	0.323000													32	71					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64825542	64825542	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:64825542G>A	uc001ssb.2	+	18	2627	c.2201G>A	c.(2200-2202)TGT>TAT	p.C734Y		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	734	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		CTCAAAGATTGTGAAGCAAAA	0.413000													41	89					0	0	1	0	0
LEMD3	23592	broad.mit.edu	37	12	65637238	65637238	+	Silent	SNP	T	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:65637238T>C	uc001ssl.1	+	10	2382	c.2376T>C	c.(2374-2376)TTT>TTC	p.F792F	LEMD3_uc009zqo.1_Silent_p.F791F	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	792	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GGAATATGTTTGATCCCGTTA	0.318000													41	62					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70048984	70048984	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:70048984G>A	uc001svg.2	-	10	1937	c.1710C>T	c.(1708-1710)AGC>AGT	p.S570S	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Silent_p.S357S|BEST3_uc010stm.1_Silent_p.S464S	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	570	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TTTCCTCAGCGCTGGCTGAAA	0.557000													22	77					0	0	1	0	0
C12orf12	196477	broad.mit.edu	37	12	91348005	91348005	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:91348005G>A	uc001tbj.2	-	1	949	c.515C>T	c.(514-516)CCG>CTG	p.P172L		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	172										central_nervous_system(1)|pancreas(1)	2						CAGCTTGACCGGCCGCGGCAG	0.667000													37	79					0	0	1	0	0
CCDC41	51134	broad.mit.edu	37	12	94769688	94769688	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:94769688G>A	uc001tdd.2	-	8	1493	c.907C>T	c.(907-909)CGA>TGA	p.R303*	CCDC41_uc001tde.2_Nonsense_Mutation_p.R303*|CCDC41_uc009zsw.1_RNA|CCDC41_uc001tdf.2_Nonsense_Mutation_p.R303*	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	295	Potential.										0						TTTATTTCTCGTTCAGCTTTA	0.254000													5	18					0	0	1	0	0
NT5DC3	51559	broad.mit.edu	37	12	104208744	104208744	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:104208744C>T	uc010swe.1	-	2	405	c.364G>A	c.(364-366)GCA>ACA	p.A122T		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	122							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						AGGTCCCGTGCAGCATTAAAT	0.448000													74	121					0	0	1	0	0
TDG	6996	broad.mit.edu	37	12	104376688	104376688	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:104376688C>T	uc001tkg.2	+	5	813	c.590C>T	c.(589-591)ACG>ATG	p.T197M	TDG_uc009zuk.2_Missense_Mutation_p.T193M|TDG_uc010swi.1_Missense_Mutation_p.T54M|TDG_uc010swj.1_Missense_Mutation_p.R13C	NM_003211	NP_003202	Q13569	TDG_HUMAN	thymine-DNA glycosylase	197					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			ovary(3)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(302;0.00114)		GAAAGGACCACGCCCGGCAGC	0.463000								BER_DNA_glycosylases					63	118					0	0	1	0	0
KCTD10	83892	broad.mit.edu	37	12	109889453	109889453	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:109889453C>T	uc001toi.1	-	7	977	c.889G>A	c.(889-891)GTG>ATG	p.V297M	KCTD10_uc001toh.1_RNA|KCTD10_uc009zvi.1_Missense_Mutation_p.V271M|KCTD10_uc001toj.1_Missense_Mutation_p.V306M|KCTD10_uc001tok.1_Missense_Mutation_p.V116M	NM_031954	NP_114160	Q9H3F6	BACD3_HUMAN	potassium channel tetramerisation domain	297					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|nucleus|voltage-gated potassium channel complex	voltage-gated potassium channel activity				0						ATCCTCCGCACGCGCTCGATC	0.716000													46	80					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120128190	120128190	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:120128190C>T	uc001txi.1	-	46	5879	c.5826G>A	c.(5824-5826)GCG>GCA	p.A1942A	CIT_uc001txh.1_Silent_p.A1460A|CIT_uc001txj.1_Silent_p.A1984A	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1942					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTTCGGGCGGCGCTGGGCTGG	0.706000													13	22					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120189940	120189940	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:120189940G>A	uc001txi.1	-	22	2746	c.2693C>T	c.(2692-2694)GCG>GTG	p.A898V	CIT_uc001txh.1_Missense_Mutation_p.A432V|CIT_uc001txj.1_Missense_Mutation_p.A940V	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	898	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTCCAGGGCCGCCCGTGCAGC	0.627000													30	58					0	0	1	0	0
RNF10	9921	broad.mit.edu	37	12	121000755	121000755	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:121000755A>G	uc001typ.3	+	8	1619	c.1136A>G	c.(1135-1137)GAA>GGA	p.E379G	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.E285G	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	379					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAGACTCGGGAAGAGGCTCTG	0.547000													31	66					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123473364	123473364	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:123473364G>A	uc001uej.1	-	18	2926	c.2787C>T	c.(2785-2787)GAC>GAT	p.D929D	PITPNM2_uc001uek.1_Silent_p.D923D	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	929	DDHD.				metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CCGTGAGGGCGTCAGGGCAGT	0.642000													6	15					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123479976	123479976	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:123479976C>T	uc001uej.1	-	13	2153	c.2014G>A	c.(2014-2016)GAG>AAG	p.E672K	PITPNM2_uc001uek.1_Missense_Mutation_p.E672K	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	672					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GTATCCAGCTCGTAGGTGGAT	0.647000													27	124					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124826571	124826571	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:124826571C>T	uc010tba.1	-	34	5127	c.5010G>A	c.(5008-5010)CCG>CCA	p.P1670P	NCOR2_uc010tay.1_Silent_p.P1669P|NCOR2_uc010taz.1_Silent_p.P1653P|NCOR2_uc010tbb.1_Silent_p.P1662P|NCOR2_uc010tbc.1_Silent_p.P1652P|NCOR2_uc010tax.1_5'Flank	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1670					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGTACAGGTGCGGGTAGGTGG	0.652000													24	55					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125434988	125434988	+	Missense_Mutation	SNP	C	T	T	rs146274723	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:125434988C>T	uc001ugy.2	-	23	3191	c.3092G>A	c.(3091-3093)CGG>CAG	p.R1031Q	DHX37_uc001ugz.1_Missense_Mutation_p.R118Q	NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	1031							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		ACACAGCACCCGCCCCCGCTC	0.657000													29	32					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129566505	129566505	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:129566505G>A	uc009zyl.1	-	7	2050	c.1722C>T	c.(1720-1722)CAC>CAT	p.H574H	TMEM132D_uc001uia.2_Silent_p.H112H	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	574	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCACCATGGCGTGCTGGTACT	0.657000													46	79					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130921520	130921520	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:130921520G>A	uc001uil.2	-	10	2086	c.1922C>T	c.(1921-1923)CCG>CTG	p.P641L	RIMBP2_uc001uim.2_Missense_Mutation_p.P549L|RIMBP2_uc001uin.1_Missense_Mutation_p.P300L	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	641	Pro-rich.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCCCACGGGCGGCTCCAGCAT	0.711000													16	16					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130927121	130927121	+	Missense_Mutation	SNP	G	A	A	rs147881182	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:130927121G>A	uc001uil.2	-	8	889	c.725C>T	c.(724-726)ACG>ATG	p.T242M	RIMBP2_uc001uim.2_Missense_Mutation_p.T150M|RIMBP2_uc001uin.1_Translation_Start_Site	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	242						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GTTCCCCAGCGTGCTTGCCAA	0.592000													30	118					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133214643	133214643	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:133214643G>A	uc001uks.1	-	41	5679	c.5635C>T	c.(5635-5637)CGT>TGT	p.R1879C	POLE_uc001ukq.1_Missense_Mutation_p.R89C|POLE_uc001ukr.1_Missense_Mutation_p.R683C|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1879					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TCTTCCACACGGCGCTTCTTT	0.547000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					21	129					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133250239	133250239	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:133250239G>A	uc001uks.1	-	13	1325	c.1281C>T	c.(1279-1281)GCC>GCT	p.A427A	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.A400A	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	427					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TGGCCTTGGCGGCCGCCTTGA	0.582000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					124	209					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133254167	133254167	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:133254167G>A	uc001uks.1	-	7	761	c.717C>T	c.(715-717)CAC>CAT	p.H239H	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.H212H	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	239					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CACTCACCACGTGGATCTTCA	0.498000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					26	57					0	0	1	0	0
CDC16	8881	broad.mit.edu	37	13	115016143	115016143	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr13:115016143T>C	uc001vuk.1	+	12	1289	c.1091T>C	c.(1090-1092)ATG>ACG	p.M364T	CDC16_uc001vul.1_Missense_Mutation_p.M364T|CDC16_uc001vum.1_Missense_Mutation_p.M270T|CDC16_uc001vun.1_Missense_Mutation_p.M363T|CDC16_uc001vuo.1_Missense_Mutation_p.M363T	NM_003903	NP_003894	Q13042	CDC16_HUMAN	anaphase-promoting complex, subunit 6	364	TPR 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			GCACAGCTGATGAAAGGGTAC	0.428000													53	17					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20846220	20846220	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:20846220G>A	uc001vxe.2	-	39	5724	c.5684C>T	c.(5683-5685)GCG>GTG	p.A1895V	TEP1_uc010ahk.2_Missense_Mutation_p.A1238V|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.A1787V|TEP1_uc010tlh.1_Missense_Mutation_p.A233V	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1895	WD 7.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CTGGCAACCCGCATGCAGGAA	0.592000													91	34					0	0	1	0	0
NDRG2	57447	broad.mit.edu	37	14	21486616	21486616	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:21486616C>T	uc001vyy.2	-	14	1011	c.861G>A	c.(859-861)AAG>AAA	p.K287K	NDRG2_uc010tll.1_Silent_p.K283K|NDRG2_uc001vyt.2_Silent_p.K200K|NDRG2_uc001vyu.2_Silent_p.K244K|NDRG2_uc001vyv.2_Silent_p.K273K|NDRG2_uc001vyw.2_Silent_p.K273K|NDRG2_uc001vzb.2_Silent_p.K227K|NDRG2_uc001vyx.2_Silent_p.K287K|NDRG2_uc001vza.2_Silent_p.K273K|NDRG2_uc001vyz.2_Silent_p.K273K|NDRG2_uc001vzc.2_Intron|NDRG2_uc001vze.2_Silent_p.K287K|NDRG2_uc001vzd.2_Silent_p.K287K|NDRG2_uc001vzg.2_Silent_p.K273K|NDRG2_uc001vzf.2_Silent_p.K273K|NDRG2_uc010aig.2_Silent_p.K276K	NM_201540	NP_963834	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform a	287					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GGTTACTGACCTTGAGGAACG	0.572000													5	37					0	0	1	0	0
RNF31	55072	broad.mit.edu	37	14	24629769	24629769	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:24629769G>A	uc001wmn.1	+	21	3455	c.3206G>A	c.(3205-3207)CGC>CAC	p.R1069H	RNF31_uc001wml.1_Missense_Mutation_p.R918H|RNF31_uc010alg.1_Missense_Mutation_p.R828H|RNF31_uc001wmo.1_Missense_Mutation_p.R536H|RNF31_uc001wmp.2_RNA|RNF31_uc010alh.1_Missense_Mutation_p.R253H|IRF9_uc001wmq.2_5'Flank|IRF9_uc010alj.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	1069					CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		AGTATCCCCCGCAGGCGGAAG	0.562000											OREG0022619	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	17					0	0	1	0	0
RABGGTA	5875	broad.mit.edu	37	14	24737796	24737796	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:24737796G>A	uc001wof.2	-	9	1352	c.930C>T	c.(928-930)AAC>AAT	p.N310N	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Silent_p.N310N|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	310					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		GCAACTGGTCGTTGAGGGAGG	0.552000													46	21					0	0	1	0	0
KHNYN	23351	broad.mit.edu	37	14	24901644	24901644	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:24901644G>A	uc001wph.3	+	3	1379	c.1177G>A	c.(1177-1179)GCA>ACA	p.A393T	KHNYN_uc010tpc.1_Missense_Mutation_p.A434T|KHNYN_uc010alw.2_Missense_Mutation_p.A393T|CBLN3_uc001wpg.3_5'Flank	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	393										ovary(2)|liver(1)	3						GCAGGGCATGGCACGGGGTCG	0.667000											OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	51					0	0	1	0	0
FBXO34	55030	broad.mit.edu	37	14	55818984	55818984	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:55818984C>T	uc001xbu.2	+	2	2121	c.1876C>T	c.(1876-1878)CGC>TGC	p.R626C	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.R626C	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	626										ovary(2)|lung(2)|skin(1)	5						TCGAGATCCACGCTATAGAGA	0.478000													54	34					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58605364	58605364	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:58605364C>T	uc001xdc.2	-	2	824	c.713G>A	c.(712-714)GGT>GAT	p.G238D	C14orf37_uc010tro.1_Missense_Mutation_p.G276D|C14orf37_uc001xdd.2_Missense_Mutation_p.G238D|C14orf37_uc001xde.2_Missense_Mutation_p.G238D	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	238	Extracellular (Potential).					integral to membrane	binding				0						GGACTCAGCACCAGGAAAAGA	0.498000													57	32					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65253771	65253771	+	Missense_Mutation	SNP	G	A	A	rs138556050		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:65253771G>A	uc001xht.2	-	15	2966	c.2912C>T	c.(2911-2913)ACG>ATG	p.T971M	SPTB_uc001xhr.2_Missense_Mutation_p.T971M|SPTB_uc001xhs.2_Missense_Mutation_p.T971M|SPTB_uc001xhu.2_Missense_Mutation_p.T971M	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	971	Spectrin 7.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGTCTTGTCCGTGATCCACTT	0.592000													42	10					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73726060	73726060	+	Missense_Mutation	SNP	G	A	A	rs151048072		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:73726060G>A	uc010ttx.1	+	15	1955	c.1792G>A	c.(1792-1794)GAC>AAC	p.D598N	PAPLN_uc001xnw.3_Missense_Mutation_p.D571N|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.D598N|PAPLN_uc010arm.2_5'Flank	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	598						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CCCCAGGGGCGACCAAGGCAC	0.672000													57	28					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76905826	76905826	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:76905826G>A	uc001xsq.1	+	2	197	c.130G>A	c.(130-132)GGC>AGC	p.G44S	ESRRB_uc001xsr.2_Missense_Mutation_p.G44S|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	44						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CGCCAGCGGCGGCTTTGGCCT	0.692000													50	20					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91806240	91806240	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:91806240G>A	uc010aty.2	-	7	711	c.612C>T	c.(610-612)GAC>GAT	p.D204D	CCDC88C_uc010twk.1_Silent_p.D168D	NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	204					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				CGGTGCACTCGTCCCGCTGGT	0.677000													3	7					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93118358	93118358	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:93118358G>A	uc001yap.2	+	6	1116	c.964G>A	c.(964-966)GTC>ATC	p.V322I	RIN3_uc010auk.2_5'UTR|RIN3_uc001yaq.2_Missense_Mutation_p.V247I|RIN3_uc001yar.1_5'UTR|RIN3_uc001yas.1_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	322	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				tgcccccCACGTCACACCCCA	0.353000													12	5					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96864584	96864584	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:96864584C>T	uc001yfn.2	+	2	322	c.278C>T	c.(277-279)GCG>GTG	p.A93V	AK7_uc001yfm.1_Missense_Mutation_p.A93V	NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	93	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CCTGACTTTGCGGTGGAGACG	0.547000													50	34					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104490932	104490932	+	Missense_Mutation	SNP	C	T	T	rs139118201	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:104490932C>T	uc001yom.3	+	25	2663	c.2633C>T	c.(2632-2634)ACG>ATG	p.T878M	TDRD9_uc001yon.3_Missense_Mutation_p.T616M	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	878					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				CAGAAGCAGACGGTAGATCCT	0.343000													38	26					0	0	1	0	0
KIAA0284	283638	broad.mit.edu	37	14	105354097	105354097	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:105354097G>A	uc010axb.2	+	12	3745	c.3521G>A	c.(3520-3522)CGG>CAG	p.R1174Q	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.R1104Q|KIAA0284_uc001yps.2_Missense_Mutation_p.R1080Q|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1174						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		GCCATGCCCCGGAAGCGGGCC	0.697000													4	8					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106092382	106092382	+	RNA	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:106092382C>T	uc010tyt.1	-	3645		c.61636G>A			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron					Parts of antibodies, mostly variable regions.												0						AGGGGGAAGACCGATGGGCCC	0.672000													29	6					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30003072	30003072	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:30003072C>T	uc001zcr.2	-	24	4810	c.4335G>A	c.(4333-4335)GCG>GCA	p.A1445A	TJP1_uc010azl.2_Silent_p.A1433A|TJP1_uc001zcq.2_Silent_p.A1369A|TJP1_uc001zcs.2_Silent_p.A1365A	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1445					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TGTGGAGAGACGCGCTGGTGA	0.498000													56	256					0	0	1	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41102150	41102150	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:41102150C>T	uc001zmt.1	+	4	1067	c.553C>T	c.(553-555)CGC>TGC	p.R185C	DNAJC17_uc001zms.1_5'Flank|DNAJC17_uc010bbz.1_5'Flank|DNAJC17_uc010bca.1_5'Flank|DNAJC17_uc010bcb.1_5'Flank|ZFYVE19_uc001zmu.1_Missense_Mutation_p.R185C|ZFYVE19_uc001zmv.1_Missense_Mutation_p.R10C|ZFYVE19_uc001zmw.1_Missense_Mutation_p.R10C|ZFYVE19_uc001zmx.1_Missense_Mutation_p.R10C|ZFYVE19_uc010bcc.1_Missense_Mutation_p.R10C	NM_001077268	NP_001070736	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	185							zinc ion binding				0		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		AGCACGACTCCGCCAGGAGAA	0.602000													45	72					0	0	1	0	0
SQRDL	58472	broad.mit.edu	37	15	45974846	45974846	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:45974846C>T	uc001zvt.2	+	8	1224	c.1035C>T	c.(1033-1035)ACC>ACT	p.T345T	SQRDL_uc001zvu.2_Silent_p.T345T|SQRDL_uc001zvv.2_Silent_p.T345T	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	345							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		CGTCAAAGACCGCTGCTGCAG	0.463000													51	76					0	0	1	0	0
PIGB	9488	broad.mit.edu	37	15	55647590	55647590	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:55647590G>A	uc002act.2	+	12	1941	c.1625G>A	c.(1624-1626)CGG>CAG	p.R542Q	CCPG1_uc002acy.2_3'UTR|PIGB_uc010ugg.1_Missense_Mutation_p.R347Q|CCPG1_uc002acu.1_3'UTR|CCPG1_uc002acw.1_3'UTR|CCPG1_uc002acv.1_3'UTR|CCPG1_uc002acx.2_3'UTR|CCPG1_uc010bfk.1_3'UTR	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	542					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		GTCTATGAACGGAAGTTAAAA	0.358000													11	98					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67629360	67629360	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:67629360G>A	uc002aqo.1	+	5	482	c.435G>A	c.(433-435)ACG>ACA	p.T145T	IQCH_uc010ujv.1_Intron|IQCH_uc002aqn.1_Intron|IQCH_uc002aqq.1_Intron|IQCH_uc002aqp.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	145										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		CCAGCCTCACGGTTCTGCCAT	0.383000													8	134					0	0	1	0	0
UACA	55075	broad.mit.edu	37	15	70991907	70991907	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:70991907C>T	uc002asr.2	-	2	275	c.171G>A	c.(169-171)AAG>AAA	p.K57K	UACA_uc010uke.1_Silent_p.K57K|UACA_uc002asq.2_Silent_p.K44K|UACA_uc010bin.1_Silent_p.K43K	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	57	ANK 1.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						GATTGACCCCCTTTTTAGCAA	0.403000													65	90					0	0	1	0	0
SGK269	79834	broad.mit.edu	37	15	77425402	77425402	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:77425402G>A	uc002bcm.2	-	5	4330	c.4022C>T	c.(4021-4023)GCG>GTG	p.A1341V		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1341	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		ATAGTAAACCGCATCACCTGC	0.413000													6	118					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78207601	78207601	+	Silent	SNP	G	A	A	rs28451071	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:78207601G>A	uc010bky.2	-	18	2075	c.1311C>T	c.(1309-1311)GCC>GCT	p.A437A	LOC645752_uc010umq.1_Silent_p.A84A|uc002bcw.1_5'Flank|uc002bcx.1_5'Flank	NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						AACCCTCCCTGGCCGCTCCTG	0.592000													6	50					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651306	84651306	+	Missense_Mutation	SNP	G	A	A	rs150618994		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:84651306G>A	uc002bjz.3	+	21	3150	c.2926G>A	c.(2926-2928)GAC>AAC	p.D976N	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.D976N|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.D976N	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	976	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGCTGCCCCCGACATCGGCGT	0.567000													68	116					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85382932	85382932	+	Splice_Site	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:85382932G>A	uc002ble.2	+	5	1196	c.1029_splice	c.e5-1	p.R343_splice		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3						heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCTACCTCTAGGTGTCGAGAA	0.647000													53	103					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85403041	85403041	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:85403041G>A	uc002ble.2	+	8	4773	c.4606G>A	c.(4606-4608)GTG>ATG	p.V1536M		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1536	Ig-like 2.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTTGGCCATCGTGCAGGCCTC	0.657000													36	42					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86800128	86800128	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:86800128G>A	uc002blz.1	+	7	722	c.642G>A	c.(640-642)GTG>GTA	p.V214V		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	214					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TCTCTGTGGTGCTTCAGATCC	0.562000													8	39					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90176401	90176401	+	Missense_Mutation	SNP	C	T	T	rs149548398		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:90176401C>T	uc002bof.2	-	13	2766	c.2689G>A	c.(2689-2691)GGC>AGC	p.G897S	KIF7_uc010upw.1_Missense_Mutation_p.G383S	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	897	Potential.				microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			ACCACAGAGCCGTTGCTGCCA	0.622000													6	20					0	0	1	0	0
MAN2A2	4122	broad.mit.edu	37	15	91455396	91455396	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:91455396G>A	uc010bnz.2	+	15	2348	c.2233G>A	c.(2233-2235)GTC>ATC	p.V745I	MAN2A2_uc002bqc.2_Missense_Mutation_p.V745I|MAN2A2_uc010uql.1_Missense_Mutation_p.V407I|MAN2A2_uc010uqm.1_Missense_Mutation_p.V324I|MAN2A2_uc010uqn.1_RNA	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	745	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GCAGCTGTCCGTCAGCAGGCA	0.647000													45	170					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93489391	93489391	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:93489391T>C	uc002bsp.2	+	12	1897	c.1322T>C	c.(1321-1323)ATT>ACT	p.I441T	CHD2_uc002bsn.2_Missense_Mutation_p.I441T|CHD2_uc002bso.1_Missense_Mutation_p.I441T|CHD2_uc010urb.1_Missense_Mutation_p.I454T|CHD2_uc010bof.1_RNA	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	441	Chromo 2.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CAGAATTGCATTGACAGCTTC	0.418000													49	67					0	0	1	0	0
C15orf51	196968	broad.mit.edu	37	15	100339849	100339849	+	RNA	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:100339849G>A	uc010urx.1	-	4		c.1078C>T			C15orf51_uc010ury.1_RNA|uc002bvp.2_5'Flank|C15orf51_uc010urz.1_RNA|uc002bvq.2_5'Flank|uc002bvt.1_5'Flank	NR_003260				Homo sapiens cDNA FLJ43799 fis, clone TESTI4000288.												0						GCAGCTAGGCGTCGTCCACGG	0.642000													22	60					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101567987	101567987	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:101567987G>A	uc002bwr.2	+	19	2990	c.2671G>A	c.(2671-2673)GAG>AAG	p.E891K	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	891					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAAGGACTACGAGGACCTGCA	0.617000													5	10					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	814961	814961	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:814961G>A	uc002cjw.1	+	7	486	c.435G>A	c.(433-435)ACG>ACA	p.T145T	MSLN_uc002cjt.1_Silent_p.T145T|MSLN_uc002cju.1_Silent_p.T145T|MSLN_uc010brd.1_Silent_p.T144T|MSLN_uc002cjv.1_Silent_p.T145T|MSLN_uc002cjx.1_Silent_p.T145T|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	145					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				CCCGCATCACGAAGGCCAATG	0.701000													11	34					0	0	1	0	0
RPUSD1	113000	broad.mit.edu	37	16	836114	836114	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:836114C>T	uc002cka.2	-	5	1009	c.775G>A	c.(775-777)GAC>AAC	p.D259N	RPUSD1_uc002ckb.2_Missense_Mutation_p.D259N|RPUSD1_uc002ckc.2_Missense_Mutation_p.D130N|RPUSD1_uc002ckd.2_3'UTR|CHTF18_uc010uus.1_5'Flank|CHTF18_uc010bre.1_5'Flank|CHTF18_uc002cke.3_5'Flank|CHTF18_uc002ckf.3_5'Flank|CHTF18_uc010brf.2_5'Flank|CHTF18_uc002ckg.3_5'Flank	NM_058192	NP_478072	Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing	259	Pro-rich.				pseudouridine synthesis		pseudouridine synthase activity|RNA binding				0		Hepatocellular(780;0.00335)				GGGTCAGGGTCGGGGGTGGCC	0.726000													51	38					0	0	1	0	0
PRR25	388199	broad.mit.edu	37	16	855739	855739	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:855739G>A	uc010uut.1	+	1	297	c.297G>A	c.(295-297)CCG>CCA	p.P99P		NM_001013638	NP_001013660	Q96S07	PRR25_HUMAN	proline rich 25	99										large_intestine(1)	1						CAGCGCAGCCGCTCGCAAATG	0.647000													19	26					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1250283	1250283	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:1250283G>A	uc002cks.2	+	7	1079	c.831G>A	c.(829-831)CCG>CCA	p.P277P	CACNA1H_uc002ckt.2_Silent_p.P277P	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	277	Extracellular (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TCCTGCGGCCGTACTACCAGA	0.632000													3	25					0	0	1	0	0
TPSAB1	7177	broad.mit.edu	37	16	1292148	1292148	+	Silent	SNP	C	T	T	rs147278526	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:1292148C>T	uc002ckz.2	+	6	787	c.735C>T	c.(733-735)GGC>GGT	p.G245G	TPSAB1_uc010uux.1_Silent_p.G181G	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	245	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				TCAGCTGGGGCGAGGGCTGTG	0.657000													11	36					0	0	1	0	0
RAB26	25837	broad.mit.edu	37	16	2202854	2202854	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:2202854C>T	uc002cou.2	+	6	636	c.502C>T	c.(502-504)CAC>TAC	p.H168Y	RAB26_uc010bsf.2_Missense_Mutation_p.H102Y|TRAF7_uc002cow.2_5'Flank	NM_014353	NP_055168	Q9ULW5	RAB26_HUMAN	RAB26, member RAS oncogene family	168					exocrine system development|protein transport|regulation of exocytosis|small GTPase mediated signal transduction	intrinsic to plasma membrane	GTP binding|protein binding				0						GTACGCCCAGCACGACGTGGC	0.687000													17	47					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2367755	2367755	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:2367755C>T	uc002cpy.1	-	9	1596	c.884G>A	c.(883-885)CGC>CAC	p.R295H	ABCA3_uc010bsk.1_Missense_Mutation_p.R295H|ABCA3_uc010bsl.1_Missense_Mutation_p.R295H	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	295					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CCCCATCATGCGCATGTACTC	0.627000													51	62					0	0	1	0	0
NTN3	4917	broad.mit.edu	37	16	2522004	2522004	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:2522004C>T	uc002cqj.2	+	1	505	c.302C>T	c.(301-303)GCG>GTG	p.A101V		NM_006181	NP_006172	O00634	NET3_HUMAN	netrin 3 precursor	101	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				central_nervous_system(1)	1						CTGCCTCGGGCGCCCCTCAAC	0.706000													15	53					0	0	1	0	0
NTN3	4917	broad.mit.edu	37	16	2522180	2522180	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:2522180C>T	uc002cqj.2	+	1	681	c.478C>T	c.(478-480)CGT>TGT	p.R160C	TBC1D24_uc002cqk.2_5'Flank|TBC1D24_uc002cql.2_5'Flank	NM_006181	NP_006172	O00634	NET3_HUMAN	netrin 3 precursor	160	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				central_nervous_system(1)	1						GGACTATGGCCGTCTGCCTGC	0.697000													18	44					0	0	1	0	0
ZNF205	7755	broad.mit.edu	37	16	3169669	3169669	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:3169669C>T	uc002cub.2	+	7	1143	c.1008C>T	c.(1006-1008)TAC>TAT	p.Y336Y	ZNF205_uc002cua.2_Silent_p.Y336Y	NM_001042428	NP_001035893	O95201	ZN205_HUMAN	zinc finger protein 205	336	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						AGAAGCCCTACGCCTGCACTG	0.682000													86	89					0	0	1	0	0
ABAT	18	broad.mit.edu	37	16	8858658	8858658	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:8858658G>A	uc002czc.3	+	8	677	c.511G>A	c.(511-513)GCC>ACC	p.A171T	ABAT_uc002czd.3_Missense_Mutation_p.A171T|ABAT_uc010buh.2_Missense_Mutation_p.A113T|ABAT_uc010bui.2_Missense_Mutation_p.A171T	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	171				MSQLITMACGSCSNENA -> CPSSSPWPACPAPMKTT (in Ref. 2; AAB38510).	behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding	p.A171T(1)		upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	CAATGAAAACGCCTTAAAGAC	0.537000													25	97					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15711316	15711316	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:15711316G>A	uc002ddr.2	-	14	2990	c.2797C>T	c.(2797-2799)CGG>TGG	p.R933W	KIAA0430_uc002ddq.2_Missense_Mutation_p.R767W|KIAA0430_uc010uzv.1_Missense_Mutation_p.R929W|KIAA0430_uc010uzw.1_Missense_Mutation_p.R932W	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	932						peroxisome	nucleotide binding|RNA binding				0						CACACCAGCCGTCCGTTTCCT	0.512000													16	56					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15758701	15758701	+	Silent	SNP	G	A	A	rs143820142		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:15758701G>A	uc002ddt.1	+	1	109	c.66G>A	c.(64-66)GCG>GCA	p.A22A	NDE1_uc010uzy.1_Silent_p.A22A|NDE1_uc002dds.2_Silent_p.A22A	NM_017668	NP_060138	Q9NXR1	NDE1_HUMAN	nuclear distribution gene E homolog 1	22	Self-association (By similarity).|Potential.				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			ovary(1)	1						AAGATCTGGCGATGACCTACA	0.343000													90	80					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21049298	21049298	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:21049298C>T	uc010vbe.1	-	34	4735	c.4735G>A	c.(4735-4737)GCC>ACC	p.A1579T		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1579	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATCTTCTGGGCGAGACTAGAA	0.552000													4	45					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27445714	27445714	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:27445714G>A	uc002doq.1	+	3	329	c.96G>A	c.(94-96)ACG>ACA	p.T32T	IL21R_uc002dor.1_Silent_p.T32T|IL21R_uc002dos.1_Silent_p.T32T	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	32	Extracellular (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						ACCTCCAGACGGTCATCTGCA	0.632000			T	BCL6	NHL								46	43					0	0	1	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29900012	29900012	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:29900012C>T	uc002duq.3	-	6	1128	c.888G>A	c.(886-888)CCG>CCA	p.P296P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.P226P|SEZ6L2_uc002dur.3_Silent_p.P226P|SEZ6L2_uc002dus.3_Silent_p.P182P|SEZ6L2_uc010vec.1_Silent_p.P296P|SEZ6L2_uc010ved.1_Silent_p.P252P	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	296	Sushi 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CCCCATGGGCCGGCCGGGGAG	0.637000													14	75					0	0	1	0	0
C16orf92	146378	broad.mit.edu	37	16	30035371	30035371	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:30035371C>T	uc002dvs.2	+	3	362	c.341C>T	c.(340-342)GCG>GTG	p.A114V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|C16orf92_uc002dvr.2_Missense_Mutation_p.A92V	NM_001109660	NP_001103130	Q96LL3	CP092_HUMAN	hypothetical protein LOC146378 isoform 2	114	Helical; (Potential).					integral to membrane					0						CTGGTGGTGGCGTTCTTCTTT	0.582000													63	74					0	0	1	0	0
LOC595101	595101	broad.mit.edu	37	16	30316394	30316394	+	RNA	SNP	C	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:30316394C>G	uc002dxp.1	-	3		c.702G>C				NR_002453				Homo sapiens cDNA FLJ39663 fis, clone SMINT2007187.												0						TTCCTCATGTCTTTGGTGGCT	0.483000													3	36					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31230620	31230620	+	Missense_Mutation	SNP	G	A	A	rs140684083	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:31230620G>A	uc002ebn.1	+	4	726	c.497G>A	c.(496-498)CGT>CAT	p.R166H	PYDC1_uc002ebo.2_5'Flank	NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	166	Potential.				exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						GAGACAGTGCGTCAGTTCCGG	0.647000													40	134					0	0	1	0	0
C16orf58	64755	broad.mit.edu	37	16	31512031	31512031	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:31512031C>T	uc002eci.1	-	3	449	c.437G>A	c.(436-438)CGC>CAC	p.R146H	C16orf58_uc010vfq.1_Missense_Mutation_p.R4H	NM_022744	NP_073581	Q96GQ5	CP058_HUMAN	hypothetical protein LOC64755	146						integral to membrane				ovary(1)|breast(1)	2						AAAGACGATGCGGCCCAGCAT	0.512000													14	54					0	0	1	0	0
CSDAP1	440359	broad.mit.edu	37	16	31580425	31580425	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:31580425G>A	uc010vfr.1	-	1	421	c.394C>T	c.(394-396)CGC>TGC	p.R132C		NR_027011				SubName: Full=CSDA protein variant; Flags: Fragment;												0						CCTACACTGCGCAGATATTTC	0.438000													19	89					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890622	32890622	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:32890622T>G	uc002edh.1	-	5	440	c.264A>C	c.(262-264)AAA>AAC	p.K88N	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						CGTTGGTGTTTTTGTAGACCA	0.512000													3	30					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53190078	53190078	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:53190078C>T	uc002ehb.2	+	1	241	c.77C>T	c.(76-78)GCA>GTA	p.A26V	CHD9_uc002egy.2_Missense_Mutation_p.A26V|CHD9_uc002egz.1_Missense_Mutation_p.A26V|CHD9_uc002eha.1_Missense_Mutation_p.A26V|CHD9_uc002ehc.2_Missense_Mutation_p.A26V	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	26					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TCAGATGATGCATTTGTACAA	0.388000													6	45					0	0	1	0	0
LPCAT2	54947	broad.mit.edu	37	16	55613052	55613052	+	Missense_Mutation	SNP	C	T	T	rs142090669	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:55613052C>T	uc002eie.3	+	13	1527	c.1346C>T	c.(1345-1347)ACG>ATG	p.T449M	LPCAT2_uc002eic.2_Missense_Mutation_p.T179M	NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	449	2 (Potential).|EF-hand 2.|Lumenal (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0						GGCTACATAACGGAGGAAGAG	0.433000													19	131					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66424460	66424460	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:66424460C>T	uc002eom.3	+	6	1092	c.936C>T	c.(934-936)CCC>CCT	p.P312P	CDH5_uc002eon.1_Silent_p.P312P	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	312	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		AGACAAACCCCGCCCACAACG	0.557000													53	47					0	0	1	0	0
TRADD	8717	broad.mit.edu	37	16	67188655	67188655	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:67188655C>T	uc002eri.1	-	5	916	c.836G>A	c.(835-837)CGC>CAC	p.R279H	TRADD_uc002erh.1_Missense_Mutation_p.R219H	NM_003789	NP_003780	Q15628	TRADD_HUMAN	TNFRSF1A-associated via death domain	279	Interaction with KRT14 and KRT18.|Death.				activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|tumor necrosis factor-mediated signaling pathway	cytoskeleton|cytosol|receptor complex	binding, bridging|death domain binding|identical protein binding|kinase binding|signal transducer activity			lung(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		CAGCGTGGCGCGGCGGCCCTC	0.706000													7	19					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67289369	67289369	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:67289369G>A	uc002esm.2	+	4	791	c.728G>A	c.(727-729)GGA>GAA	p.G243E	SLC9A5_uc010cee.2_5'UTR|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	243					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		TACCTGAAGGGAGTCGGTCAG	0.587000													56	60					0	0	1	0	0
CENPT	80152	broad.mit.edu	37	16	67863714	67863714	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:67863714G>A	uc002eun.3	-	12	1689	c.1140C>T	c.(1138-1140)GAC>GAT	p.D380D	CENPT_uc002eum.3_Intron|CENPT_uc010vkc.1_Silent_p.D138D|CENPT_uc010vkd.1_Silent_p.D133D|CENPT_uc010vke.1_3'UTR	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	380					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		CTCCTGGCCCGTCAGCCTCAG	0.612000													57	149					0	0	1	0	0
DDX19A	55308	broad.mit.edu	37	16	70400563	70400563	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:70400563C>T	uc002eyv.2	+	9	890	c.819C>T	c.(817-819)TCC>TCT	p.S273S	DDX19B_uc010vly.1_Intron|DDX19A_uc002eys.2_Silent_p.S274S|DDX19A_uc010cfq.1_Silent_p.S28S|DDX19A_uc010cfr.2_Silent_p.S123S|DDX19A_uc010cfs.2_Silent_p.S96S|DDX19A_uc010vlz.1_Silent_p.S242S|DDX19A_uc010vma.1_Silent_p.S183S	NM_018332	NP_060802	Q9NUU7	DD19A_HUMAN	DDX19-like protein	273	Helicase ATP-binding.				mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)				TGCTTTTCTCCGCCACCTTTG	0.562000													43	92					0	0	1	0	0
MARVELD3	91862	broad.mit.edu	37	16	71674814	71674814	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:71674814G>A	uc002fau.2	+	3	1180	c.1117G>A	c.(1117-1119)GCC>ACC	p.A373T	PHLPP2_uc002fav.2_RNA|MARVELD3_uc010cge.2_3'UTR	NM_001017967	NP_001017967	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane				skin(1)	1		Ovarian(137;0.125)				CATGTACGGCGCCAGCGTGGT	0.597000													35	38					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72130788	72130788	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:72130788C>T	uc002fcb.2	+	3	746	c.391C>T	c.(391-393)CGC>TGC	p.R131C	TXNL4B_uc010vmo.1_5'Flank|DHX38_uc010vmp.1_Intron|DHX38_uc010cgn.1_RNA	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	131					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				GTTTTGGGAACGCAGTCGGCA	0.547000													148	154					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72133711	72133711	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:72133711C>T	uc002fcb.2	+	8	1396	c.1041C>T	c.(1039-1041)TAC>TAT	p.Y347Y	DHX38_uc010vmp.1_Intron|DHX38_uc010cgn.1_RNA	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	347					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				CCGAGGACTACGTGAGGAGGC	0.577000											OREG0023926	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	19					0	0	1	0	0
CDT1	81620	broad.mit.edu	37	16	88873762	88873762	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:88873762G>A	uc002flu.2	+	9	1403	c.1349G>A	c.(1348-1350)CGC>CAC	p.R450H		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	450					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		CGGCTGCAGCGCTTAGAACGG	0.657000													34	41					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88958664	88958664	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:88958664C>T	uc002fmm.1	-	4	795	c.609G>A	c.(607-609)GTG>GTA	p.V203V	CBFA2T3_uc002fml.1_Silent_p.V117V|CBFA2T3_uc010cif.1_Silent_p.V142V|CBFA2T3_uc002fmn.1_Silent_p.V178V	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	203	TAFH.|Mediates localization to the nucleus (By similarity).|Mediates interaction with PDE7A (in isoform 2).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CCAGGCCCAGCACCAGTGTGC	0.627000			T	RUNX1	AML								20	63					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89256813	89256813	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:89256813C>T	uc002fmt.2	+	8	1218	c.1141C>T	c.(1141-1143)CGG>TGG	p.R381W		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	381	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GAACCCACTTCGGACCAGCCT	0.687000													6	27					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89347172	89347172	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:89347172C>T	uc002fmx.1	-	9	6239	c.5778G>A	c.(5776-5778)CCG>CCA	p.P1926P	ANKRD11_uc002fmy.1_Silent_p.P1926P|ANKRD11_uc002fnc.1_Silent_p.P1926P|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Silent_p.P1883P	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1926	Pro-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		AGCTGGGCTCCGGGGGGATGA	0.711000													10	101					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89614459	89614459	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:89614459G>A	uc002fnj.2	+	12	1622	c.1601G>A	c.(1600-1602)CGG>CAG	p.R534Q	SPG7_uc002fnk.1_RNA|SPG7_uc002fnl.2_5'Flank	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	534	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		CACGCGGCGCGGGAGGGACAC	0.642000													49	221					0	0	1	0	0
SGSM2	9905	broad.mit.edu	37	17	2265510	2265510	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:2265510C>T	uc002fun.3	+	4	579	c.404C>T	c.(403-405)GCG>GTG	p.A135V	SGSM2_uc002fum.3_Missense_Mutation_p.A135V|SGSM2_uc010vqw.1_Missense_Mutation_p.A135V	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	135	RUN.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		GTACGCACGGCGCTCATCGAG	0.637000													46	149					0	0	1	0	0
OR1D2	4991	broad.mit.edu	37	17	2995776	2995776	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:2995776C>T	uc010vrb.1	-	1	515	c.515G>A	c.(514-516)CGA>CAA	p.R172Q		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	172	Extracellular (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GTGGATTTTTCGTGACCCACA	0.468000													52	17					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3999984	3999984	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:3999984C>T	uc002fxe.2	-	10	1747	c.1683G>A	c.(1681-1683)ACG>ACA	p.T561T	ZZEF1_uc002fxk.1_Silent_p.T561T	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	561							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TTCCAGTTTCCGTAAGAAAAC	0.368000													89	27					0	0	1	0	0
GGT6	124975	broad.mit.edu	37	17	4461802	4461802	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:4461802G>A	uc002fyd.3	-	4	1050	c.990C>T	c.(988-990)TCC>TCT	p.S330S	GGT6_uc010vsb.1_Silent_p.S182S|GGT6_uc002fyc.3_Silent_p.S298S|GGT6_uc010vsc.1_Silent_p.S336S	NM_001122890	NP_001116362	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6 isoform a	330	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			skin(1)	1						TGGGCGCCCCGGAGCGCAGGG	0.692000													3	13					0	0	1	0	0
CHRNE	1145	broad.mit.edu	37	17	4804399	4804399	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:4804399C>T	uc002fzk.1	-	7	699	c.688G>A	c.(688-690)GTC>ATC	p.V230I	C17orf107_uc002fzl.3_3'UTR	NM_000080	NP_000071	Q04844	ACHE_HUMAN	nicotinic acetylcholine receptor epsilon	230	Extracellular (Potential).				muscle contraction|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						GAGTAGATGACGTCAGTCTCC	0.652000													114	62					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577138	7577138	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:7577138C>T	uc002gim.2	-	8	994	c.800G>A	c.(799-801)CGG>CAG	p.R267Q	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R267Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R135Q|TP53_uc010cng.1_Missense_Mutation_p.R135Q|TP53_uc002gii.1_Missense_Mutation_p.R135Q|TP53_uc010cnh.1_Missense_Mutation_p.R267Q|TP53_uc010cni.1_Missense_Mutation_p.R267Q|TP53_uc002gij.2_Missense_Mutation_p.R267Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	267	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> H (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R267W(20)|p.R267P(13)|p.0?(7)|p.R267Q(7)|p.R267R(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.R267fs*78(1)|p.N268fs*77(1)|p.L265_K305del41(1)|p.R267G(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.R267L(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAAGCTGTTCCGTCCCAGTAG	0.527000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			40	14					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578463	7578463	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:7578463C>T	uc002gim.2	-	5	661	c.467G>A	c.(466-468)CGC>CAC	p.R156H	TP53_uc002gig.1_Missense_Mutation_p.R156H|TP53_uc002gih.2_Missense_Mutation_p.R156H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R24H|TP53_uc010cng.1_Missense_Mutation_p.R24H|TP53_uc002gii.1_Missense_Mutation_p.R24H|TP53_uc010cnh.1_Missense_Mutation_p.R156H|TP53_uc010cni.1_Missense_Mutation_p.R156H|TP53_uc002gij.2_Missense_Mutation_p.R156H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R63H|TP53_uc002gio.2_Missense_Mutation_p.R24H|TP53_uc010vug.1_Missense_Mutation_p.R117H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	156	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R156P(24)|p.R156H(10)|p.R156fs*14(8)|p.0?(7)|p.R156S(3)|p.R156R(3)|p.R156fs*25(3)|p.R156G(3)|p.R156L(3)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.P153fs*22(2)|p.R156C(2)|p.T155_R156delTR(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156del(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.G154_R156delGTR(1)|p.R156fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCGCGGACGCGGGTGCCGGG	0.612000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			72	24					0	0	1	0	0
PFAS	5198	broad.mit.edu	37	17	8167651	8167651	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:8167651G>A	uc002gkr.2	+	16	2054	c.1913G>A	c.(1912-1914)CGG>CAG	p.R638Q	PFAS_uc010vuv.1_Missense_Mutation_p.R214Q|PFAS_uc010cnw.1_Missense_Mutation_p.R138Q|PFAS_uc002gks.2_5'Flank	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	638					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AAGATGCCTCGGAAGGTATGT	0.622000													48	11					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10299869	10299869	+	Splice_Site	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:10299869C>T	uc002gmm.2	-	32	4623	c.4528_splice	c.e32+1	p.Q1510_splice	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,						muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TGAGGACTCACGTTGCAAGTT	0.463000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				33	14					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11660881	11660881	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:11660881G>A	uc002gne.2	+	35	6935	c.6867G>A	c.(6865-6867)CCG>CCA	p.P2289P	DNAH9_uc010coo.2_Silent_p.P1583P	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2289	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACATCAACCCGGCAGACTTGG	0.428000													16	62					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11711063	11711063	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:11711063G>A	uc002gne.2	+	44	8503	c.8435G>A	c.(8434-8436)CGC>CAC	p.R2812H	DNAH9_uc010coo.2_Missense_Mutation_p.R2106H	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2812	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CATATCAATCGCATCTTGGAG	0.532000													8	111					0	0	1	0	0
TRPV2	51393	broad.mit.edu	37	17	16336966	16336966	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:16336966G>A	uc002gpy.2	+	13	2435	c.2068G>A	c.(2068-2070)GTT>ATT	p.V690I	TRPV2_uc002gpz.2_Missense_Mutation_p.V260I	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,	690	Cytoplasmic (Potential).				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		GATGCTGACCGTTGGCACTAA	0.592000													39	145					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319341	21319341	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:21319341C>T	uc002gyv.1	+	3	1392	c.687C>T	c.(685-687)CGC>CGT	p.R229R		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	229	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCCATGTGCGCGCGCAGCTCA	0.642000										Prostate(3;0.18)			28	65					0	0	1	0	0
NEK8	284086	broad.mit.edu	37	17	27065189	27065189	+	Missense_Mutation	SNP	G	A	A	rs138066977		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:27065189G>A	uc002hcp.2	+	8	1148	c.1148G>A	c.(1147-1149)CGT>CAT	p.R383H		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	383						cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					TTCATCTCGCGTTTCCTGGAG	0.657000													18	51					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37866098	37866098	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:37866098C>T	uc002hso.2	+	5	845	c.607C>T	c.(607-609)CGC>TGC	p.R203C	ERBB2_uc002hsm.2_Missense_Mutation_p.R173C|ERBB2_uc010cwa.2_Missense_Mutation_p.R188C|ERBB2_uc002hsp.2_Missense_Mutation_p.R6C|ERBB2_uc010cwb.2_Missense_Mutation_p.R203C|ERBB2_uc010wek.1_Intron|ERBB2_uc002hsl.2_Missense_Mutation_p.R173C|ERBB2_uc002hsn.1_Missense_Mutation_p.R203C	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	203	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TAAGGGCTCCCGCTGCTGGGG	0.597000		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			74	18					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274307	39274307	+	Silent	SNP	G	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:39274307G>T	uc002hvz.2	-	1	300	c.261C>A	c.(259-261)CCC>CCA	p.P87P		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	87	13.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GGCAGCACTGGGGCTTGCAGC	0.438000													17	88					7.45023e-12	7.63002e-12	1	1	0
TUBG1	7283	broad.mit.edu	37	17	40766567	40766567	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:40766567G>A	uc002ian.2	+	10	1448	c.1050G>A	c.(1048-1050)CCG>CCA	p.P350P		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	350					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		ACTTCATCCCGTGGGGCCCCG	0.652000													108	25					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43314943	43314943	+	Silent	SNP	G	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:43314943G>T	uc002iin.2	+	9	1031	c.831G>T	c.(829-831)GCG>GCT	p.A277A		NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	277	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						AGCTGCTGGCGGCCGTGTGCT	0.607000													181	80					1.90661e-81	1.97346e-81	1	1	0
ITGA3	3675	broad.mit.edu	37	17	48157736	48157736	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:48157736C>T	uc010dbl.2	+	22	3281	c.2817C>T	c.(2815-2817)ATC>ATT	p.I939I	ITGA3_uc010dbm.2_Silent_p.I939I	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	939	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						GCACCTTCATCGAGGTCAGTG	0.577000													11	30					0	0	1	0	0
EPN3	55040	broad.mit.edu	37	17	48616601	48616601	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:48616601C>T	uc002ira.3	+	5	1251	c.816C>T	c.(814-816)GCC>GCT	p.A272A	EPN3_uc010wms.1_Silent_p.A300A|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Silent_p.A245A	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	272						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			GTGCAGGGGCCGTGGTCCACC	0.607000													73	24					0	0	1	0	0
TMEM49	81671	broad.mit.edu	37	17	57842391	57842391	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:57842391C>T	uc002ixu.3	+	6	747	c.474C>T	c.(472-474)CCC>CCT	p.P158P	TMEM49_uc010wog.1_5'UTR|TMEM49_uc010woh.1_Intron|TMEM49_uc010woi.1_Silent_p.P61P|TMEM49_uc010woj.1_Silent_p.P24P	NM_030938	NP_112200	Q96GC9	VMP1_HUMAN	transmembrane protein 49	158	Extracellular (Potential).				autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane					0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;1.15e-09)|all cancers(12;1.15e-08)			TTAATTTTCCCGAACCACCCT	0.368000													20	83					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58259033	58259033	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:58259033C>T	uc002iyo.1	-	32	4486	c.4200G>A	c.(4198-4200)CGG>CGA	p.R1400R	USP32_uc002iyn.1_Silent_p.R1070R	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1400					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TCCCCAAAGTCCGTGGGCTGC	0.483000													16	56					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62144066	62144066	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:62144066C>T	uc002jdz.2	-	8	920	c.807G>A	c.(805-807)CCG>CCA	p.P269P		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	269	Lumenal (Potential).				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						CCTTGGGGAACGGGTACTTCC	0.592000													33	5					0	0	1	0	0
BTBD17	388419	broad.mit.edu	37	17	72353024	72353024	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:72353024G>A	uc002jkn.2	-	3	1209	c.1209C>T	c.(1207-1209)GAC>GAT	p.D403D		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	403						extracellular region					0						CGCCCGCCGCGTCGCCGCCGC	0.771000													10	4					0	0	1	0	0
BTBD17	388419	broad.mit.edu	37	17	72353354	72353354	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:72353354G>A	uc002jkn.2	-	3	879	c.879C>T	c.(877-879)CAC>CAT	p.H293H		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	293						extracellular region					0						GCGACGCGGCGTGGAACTGGT	0.731000													16	3					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74289330	74289330	+	Missense_Mutation	SNP	C	T	T	rs151086130	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:74289330C>T	uc002jrd.1	-	4	1160	c.980G>A	c.(979-981)CGT>CAT	p.R327H	QRICH2_uc010wsz.1_Missense_Mutation_p.R253H|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	327							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						TACACATCCACGCTGATCCAT	0.498000													147	54					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76558007	76558007	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:76558007G>A	uc002jvv.1	-	8	837	c.731C>T	c.(730-732)GCG>GTG	p.A244V						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATACCTGGGCGCCACCTCGGC	0.587000													60	9					0	0	1	0	0
SLC38A10	124565	broad.mit.edu	37	17	79256073	79256073	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:79256073C>T	uc002jzz.1	-	5	792	c.417G>A	c.(415-417)CCG>CCA	p.P139P	SLC38A10_uc002jzy.1_Silent_p.P57P|SLC38A10_uc002kab.2_Silent_p.P139P	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	139	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GCAGGCTGAGCGGGAGCACGA	0.662000													10	58					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5423406	5423406	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr18:5423406C>T	uc002kmt.1	-	11	1396	c.1310G>A	c.(1309-1311)CGT>CAT	p.R437H	EPB41L3_uc010wzh.1_Missense_Mutation_p.R437H|EPB41L3_uc002kmu.1_Missense_Mutation_p.R437H|EPB41L3_uc010dkq.1_Missense_Mutation_p.R328H|EPB41L3_uc010dkr.2_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	437	Hydrophilic.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CATGGTATAACGTTTGCTGGA	0.478000													32	26					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21114452	21114452	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr18:21114452G>A	uc002kum.3	-	23	3823	c.3549C>T	c.(3547-3549)CGC>CGT	p.R1183R	NPC1_uc010dlu.1_5'Flank|NPC1_uc010xaz.1_Silent_p.R916R	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	1183					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CGCGCTCCACGCGGCTGCCTT	0.587000													26	19					0	0	1	0	0
RNF125	54941	broad.mit.edu	37	18	29648291	29648291	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr18:29648291C>T	uc002kxf.1	+	6	1025	c.643C>T	c.(643-645)CGA>TGA	p.R215*		NM_017831	NP_060301	Q96EQ8	RN125_HUMAN	ring finger protein 125	215					negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding				0						AGCTCTTATCCGAAGAGTCTT	0.338000													30	26					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74153957	74153957	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr18:74153957C>T	uc010dqx.1	-	2	1289	c.1054G>A	c.(1054-1056)GCC>ACC	p.A352T	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	352	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GCATTGTGGGCGTTCAAGCTG	0.657000													22	13					0	0	1	0	0
PALM	5064	broad.mit.edu	37	19	746408	746408	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:746408C>T	uc002lpm.1	+	9	952	c.758C>T	c.(757-759)GCG>GTG	p.A253V	PALM_uc002lpn.1_Missense_Mutation_p.A209V|PALM_uc010xfu.1_Missense_Mutation_p.A118V	NM_002579	NP_002570	O75781	PALM_HUMAN	paralemmin isoform 1	253					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		ACGGCCGGGGCGGCAGAGACC	0.726000													18	35					0	0	1	0	0
SHD	56961	broad.mit.edu	37	19	4290594	4290594	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:4290594G>A	uc002lzw.2	+	6	2450	c.987G>A	c.(985-987)CTG>CTA	p.L329L	SHD_uc010dtu.2_Silent_p.L289L	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	329	SH2.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGAGCATCTGGCTCTGCTGT	0.662000													36	86					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5244109	5244109	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:5244109C>T	uc002mbv.2	-	11	1607	c.1373G>A	c.(1372-1374)CGC>CAC	p.R458H	PTPRS_uc002mbu.1_Missense_Mutation_p.R445H|PTPRS_uc010xin.1_Missense_Mutation_p.R445H|PTPRS_uc002mbw.2_Missense_Mutation_p.R445H|PTPRS_uc002mbx.2_Missense_Mutation_p.R449H|PTPRS_uc002mby.2_Missense_Mutation_p.R445H	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	458	Extracellular (Potential).|Fibronectin type-III 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GCGGTAGCCGCGGATCAGGCC	0.682000													34	163					0	0	1	0	0
DUS3L	56931	broad.mit.edu	37	19	5786850	5786850	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:5786850C>T	uc002mdc.2	-	9	1493	c.1396G>A	c.(1396-1398)GGC>AGC	p.G466S	PRR22_uc002mdb.1_5'Flank|PRR22_uc010xiv.1_5'Flank|DUS3L_uc002mdd.2_Missense_Mutation_p.G224S|DUS3L_uc010duk.2_Missense_Mutation_p.G131S	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	466					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						CGAGAGCGGCCGTGGAGCTGG	0.438000													11	20					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6772867	6772867	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:6772867C>G	uc002mfu.1	+	1	146	c.49C>G	c.(49-51)CTG>GTG	p.L17V	VAV1_uc010xjh.1_Missense_Mutation_p.L17V|VAV1_uc010dva.1_Missense_Mutation_p.L17V	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	17	CH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						GTGCCGGGTGCTGCCGCCCAG	0.677000													15	80					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7619474	7619474	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:7619474C>T	uc010xjq.1	+	23	2724	c.2529C>T	c.(2527-2529)GCC>GCT	p.A843A	PNPLA6_uc002mgq.1_Silent_p.A795A|PNPLA6_uc010xjp.1_Silent_p.A768A|PNPLA6_uc002mgr.1_Silent_p.A795A|PNPLA6_uc002mgs.2_Silent_p.A833A|PNPLA6_uc002mgt.1_5'Flank	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	834	Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						GGTGGCTGGCCCAGCAGGAGG	0.652000													26	76					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8188415	8188415	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:8188415C>T	uc002mjf.2	-	23	3036	c.3015G>A	c.(3013-3015)ACG>ACA	p.T1005T		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1005	EGF-like 12; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AGCTGCCCACCGTGTTTCTGC	0.607000													40	35					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8201185	8201185	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:8201185C>T	uc002mjf.2	-	11	1375	c.1354G>A	c.(1354-1356)GAA>AAA	p.E452K		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	452	EGF-like 4; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CTGGTGCATTCGTCTACATCT	0.677000													37	103					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8601249	8601249	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:8601249G>A	uc002mkg.2	-	19	2044	c.1930C>T	c.(1930-1932)CGG>TGG	p.R644W		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	644	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CCACGCCACCGCGGCCACGTC	0.647000													59	78					0	0	1	0	0
ZNF559	84527	broad.mit.edu	37	19	9453655	9453655	+	Nonsense_Mutation	SNP	C	T	T	rs147456906	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:9453655C>T	uc002mlg.2	+	7	2175	c.1528C>T	c.(1528-1530)CGA>TGA	p.R510*	ZNF559_uc002mlf.2_Nonsense_Mutation_p.R279*|ZNF559_uc010dwl.1_Nonsense_Mutation_p.R279*|ZNF559_uc010xkn.1_Nonsense_Mutation_p.R502*|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Nonsense_Mutation_p.R574*|ZNF559_uc010dwk.1_Nonsense_Mutation_p.R279*|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	510	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATATCTTATTCGACATCTAAG	0.438000													35	90					0	0	1	0	0
ZGLP1	100125288	broad.mit.edu	37	19	10419252	10419252	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:10419252G>A	uc002mnw.3	-	1	982	c.106C>T	c.(106-108)CGT>TGT	p.R36C	FDX1L_uc002mnx.1_Intron	NM_001103167	NP_001096637	P0C6A0	ZGLP1_HUMAN	GATA like protein-1	36					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GTGGGGTCACGTTTTCTTGGG	0.617000													12	23					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10790547	10790547	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:10790547C>T	uc002mpn.2	+	8	1120	c.803C>T	c.(802-804)GCT>GTT	p.A268V	ILF3_uc002mpm.2_Missense_Mutation_p.A268V|ILF3_uc002mpl.2_Missense_Mutation_p.A268V|ILF3_uc002mpk.2_Missense_Mutation_p.A268V|ILF3_uc010xli.1_Intron|ILF3_uc002mpo.2_Missense_Mutation_p.A268V|ILF3_uc002mpp.2_Missense_Mutation_p.A89V	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	268	DZF.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CCGATGGGTGCTGGCGAGGCC	0.612000													4	89					0	0	1	0	0
CNN1	1264	broad.mit.edu	37	19	11660568	11660568	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:11660568C>T	uc002msc.1	+	7	1016	c.852C>T	c.(850-852)CCC>CCT	p.P284P	CNN1_uc010xmb.1_Silent_p.P234P|CNN1_uc010xmc.1_Silent_p.P234P	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	284					actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						TGGGTGAGCCCGCCCACAACC	0.632000													27	133					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12186611	12186611	+	Missense_Mutation	SNP	A	G	G	rs7259684	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:12186611A>G	uc002mtb.2	+	4	819	c.676A>G	c.(676-678)AAA>GAA	p.K226E	ZNF844_uc010dym.1_Missense_Mutation_p.K69E	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	226	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAACCATATAAATGTAAACA	0.373000													3	24					0	0	1	0	0
MAN2B1	4125	broad.mit.edu	37	19	12768302	12768302	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:12768302G>A	uc002mub.2	-	11	1453	c.1377C>T	c.(1375-1377)AAC>AAT	p.N459N	MAN2B1_uc010dyv.1_Silent_p.N458N	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	459					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						GCGCGTAGTCGTTGGCCACGT	0.557000													4	3					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12817117	12817117	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:12817117C>T	uc002muo.2	-	14	1746	c.1561G>A	c.(1561-1563)GAC>AAC	p.D521N	TNPO2_uc002mup.2_Missense_Mutation_p.D613N|TNPO2_uc002muq.2_Missense_Mutation_p.D521N|TNPO2_uc002mur.2_Missense_Mutation_p.D521N	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	521	HEAT 9.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						ACAAGGGTGTCCAGGATGTAG	0.587000													19	72					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15072860	15072860	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:15072860C>T	uc002naa.1	-	5	897	c.889G>A	c.(889-891)GAC>AAC	p.D297N	SLC1A6_uc010dzu.1_Missense_Mutation_p.D297N|SLC1A6_uc010xod.1_Missense_Mutation_p.D233N|SLC1A6_uc002nab.2_Missense_Mutation_p.D297N|SLC1A6_uc002nac.2_Missense_Mutation_p.D297N	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	297					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	TTGAGGCTGTCGAAGAAGTCC	0.572000													75	101					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15580456	15580456	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:15580456G>A	uc002nbf.3	-	4	1761	c.1628C>T	c.(1627-1629)CCG>CTG	p.P543L	PGLYRP2_uc002nbg.3_Missense_Mutation_p.P543L	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	543					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						GGTGAAGTGCGGCCAGGTGCG	0.721000													12	13					0	0	1	0	0
OR10H1	26539	broad.mit.edu	37	19	15918656	15918656	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:15918656G>A	uc002nbq.2	-	1	281	c.192C>T	c.(190-192)TGC>TGT	p.C64C		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CGGAGAGGGCGCACAGGAAGA	0.642000													53	118					0	0	1	0	0
KCNN1	3780	broad.mit.edu	37	19	18092920	18092920	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:18092920G>A	uc002nht.2	+	5	1211	c.901G>A	c.(901-903)GTG>ATG	p.V301M	KCNN1_uc010xqa.1_Missense_Mutation_p.V301M	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	301					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						AGCCTGGACCGTGCGCGTCTG	0.652000													12	7					0	0	1	0	0
TSSK6	83983	broad.mit.edu	37	19	19625703	19625703	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:19625703C>T	uc002nmr.2	-	1	767	c.534G>A	c.(532-534)GCG>GCA	p.A178A	TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	178	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1						CCTCGGGTGACGCGTAGGCGG	0.662000													8	48					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655182	19655182	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:19655182G>A	uc002nmv.3	+	8	1913	c.1828G>A	c.(1828-1830)GTG>ATG	p.V610M	CILP2_uc002nmw.3_Missense_Mutation_p.V616M	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	610						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GGTGACGTTCGTGGACCCCCG	0.692000													77	175					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35823774	35823774	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:35823774G>T	uc010edt.2	+	3	436	c.359G>T	c.(358-360)AGG>ATG	p.R120M	CD22_uc010xst.1_Translation_Start_Site|CD22_uc010edu.2_Missense_Mutation_p.R120M|CD22_uc010edv.2_Missense_Mutation_p.R120M|CD22_uc002nzb.3_Missense_Mutation_p.R120M	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	120	Extracellular (Potential).|Ig-like V-type.	Sialic acid (By similarity).			cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CTGGGGCTGAGGATGGAGTCC	0.542000													18	71					0.000132079	0.000133256	1	1	0
MLL4	9757	broad.mit.edu	37	19	36216664	36216664	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:36216664C>T	uc010eei.2	+	14	3830	c.3830C>T	c.(3829-3831)CCG>CTG	p.P1277L		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1277	PHD-type 2.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCATACCACCCGGCCTGTCTG	0.602000													4	12					0	0	1	0	0
GGN	199720	broad.mit.edu	37	19	38876366	38876366	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:38876366G>A	uc002oij.1	-	3	1671	c.1536C>T	c.(1534-1536)TCC>TCT	p.S512S	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Silent_p.S429S	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	512	Interactions with ZNF403/GGNBP2 and OAZ3 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			gtgcgggcgcggacacaggcg	0.249000													28	26					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38974156	38974156	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:38974156G>A	uc002oit.2	+	33	5064	c.4934G>A	c.(4933-4935)CGG>CAG	p.R1645Q	RYR1_uc002oiu.2_Missense_Mutation_p.R1645Q	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1645	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GAGGAGAACCGGTCAGGGCCA	0.687000													5	5					0	0	1	0	0
LGALS4	3960	broad.mit.edu	37	19	39299582	39299582	+	Silent	SNP	G	A	A	rs140167180		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:39299582G>A	uc002ojg.2	-	3	355	c.141C>T	c.(139-141)TTC>TTT	p.F47F	LGALS4_uc010xuj.1_Silent_p.F47F	NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	47	Galectin 1.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CAAAGTTCACGAAGAACCTGG	0.642000													7	19					0	0	1	0	0
NCCRP1	342897	broad.mit.edu	37	19	39691350	39691350	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:39691350G>A	uc002okq.1	+	6	801	c.782G>A	c.(781-783)CGG>CAG	p.R261Q		NM_001001414	NP_001001414	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1	261	FBA.				protein catabolic process					ovary(1)	1						GGGCTGCGGCGGACACGGGTG	0.632000													196	246					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40913824	40913824	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:40913824G>A	uc002onr.2	-	4	285	c.16C>T	c.(16-18)CGG>TGG	p.R6W	PRX_uc002ons.2_Missense_Mutation_p.R6W	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	6					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCGGCACTCCGGCTCCTGGCC	0.592000													23	62					0	0	1	0	0
LYPD4	147719	broad.mit.edu	37	19	42343292	42343292	+	Splice_Site	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:42343292C>T	uc002orp.1	-	2	1051	c.67_splice	c.e2+1	p.R23_splice	LYPD4_uc002orq.1_Missense_Mutation_p.R23H	NM_173506	NP_775777	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4 precursor							anchored to membrane|plasma membrane				ovary(1)	1						ACAGGACATACGAGGCAGAGT	0.577000													7	147					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42912409	42912409	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:42912409G>A	uc002otr.2	-	3	1762	c.1485C>T	c.(1483-1485)CAC>CAT	p.H495H	uc010eif.1_Intron|LIPE_uc002ots.1_Silent_p.H240H	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	495					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TGCGTTTGTAGTGCTCCCCGA	0.627000													45	211					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43259265	43259265	+	Missense_Mutation	SNP	C	T	T	rs113087470		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:43259265C>T	uc002ouo.2	-	4	961	c.863G>A	c.(862-864)CGA>CAA	p.R288Q	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_Intron|PSG8_uc002oui.2_Missense_Mutation_p.R127Q|PSG8_uc002ouh.2_Missense_Mutation_p.R288Q|PSG8_uc010ein.2_Missense_Mutation_p.R166Q|PSG8_uc002ouj.3_Missense_Mutation_p.R70Q|PSG8_uc002ouk.3_Missense_Mutation_p.R127Q|PSG8_uc002oul.3_Missense_Mutation_p.R288Q|PSG8_uc002oum.3_Missense_Mutation_p.R195Q|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.R195Q	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	288	Ig-like C2-type 2.					extracellular region					0		Prostate(69;0.00899)				TTCAATGGGTCGCTTTACCCT	0.468000													63	213					0	0	1	0	0
APOE	348	broad.mit.edu	37	19	45411904	45411904	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:45411904G>A	uc002pab.2	+	4	434	c.351G>A	c.(349-351)GCG>GCA	p.A117A		NM_000041	NP_000032	P02649	APOE_HUMAN	apolipoprotein E precursor	117	8 X 22 AA approximate tandem repeats.|2.				anti-apoptosis|Cdc42 protein signal transduction|cell death|cGMP-mediated signaling|cholesterol efflux|cholesterol homeostasis|chylomicron remnant clearance|cytoskeleton organization|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|induction of apoptosis|intracellular transport|negative regulation of blood vessel endothelial cell migration|negative regulation of cholesterol biosynthetic process|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of platelet activation|nitric oxide mediated signal transduction|phospholipid efflux|positive regulation of cGMP biosynthetic process|positive regulation of cholesterol efflux|positive regulation of cholesterol esterification|positive regulation of low-density lipoprotein particle receptor catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of nitric-oxide synthase activity|receptor-mediated endocytosis|regulation of axon extension|regulation of neuronal synaptic plasticity|response to reactive oxygen species|reverse cholesterol transport|synaptic transmission, cholinergic|triglyceride metabolic process|very-low-density lipoprotein particle clearance|very-low-density lipoprotein particle remodeling	chylomicron|dendrite|high-density lipoprotein particle|intermediate-density lipoprotein particle|low-density lipoprotein particle|neuronal cell body|very-low-density lipoprotein particle	antioxidant activity|beta-amyloid binding|heparin binding|low-density lipoprotein particle receptor binding|metal chelating activity|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding|protein heterodimerization activity|protein homodimerization activity|tau protein binding|very-low-density lipoprotein particle receptor binding				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)	Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	AGCTGCAGGCGGCGCAGGCCC	0.682000													3	13					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45885827	45885827	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:45885827C>T	uc002pbn.2	-	12	2483	c.2406G>A	c.(2404-2406)GCG>GCA	p.A802A	PPP1R13L_uc002pbm.2_Silent_p.A381A|PPP1R13L_uc002pbo.2_Silent_p.A802A	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	802	SH3.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GGCCGTGCAGCGCGGCCCACC	0.697000													31	102					0	0	1	0	0
PGLYRP1	8993	broad.mit.edu	37	19	46522887	46522887	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:46522887G>A	uc002pdx.1	-	2	350	c.306C>T	c.(304-306)GAC>GAT	p.D102D		NM_005091	NP_005082	O75594	PGRP1_HUMAN	peptidoglycan recognition protein 1 precursor	102					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region	bacterial cell surface binding|N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)	2		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		ATACGAGCCCGTCTTCTCCAA	0.592000													28	34					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48908573	48908573	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:48908573G>A	uc002pjc.3	+	3	1136	c.1048G>A	c.(1048-1050)GCC>ACC	p.A350T		NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	350	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CGACTGTCGCGCCCAGAACCG	0.652000													17	7					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50265270	50265270	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:50265270C>T	uc002ppm.2	-	2	401	c.390G>A	c.(388-390)ACG>ACA	p.T130T		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	130							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CCAGGATTTCCGTGATGTCTG	0.622000													9	111					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50912844	50912844	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:50912844C>T	uc002psb.3	+	17	2131	c.2075C>T	c.(2074-2076)GCG>GTG	p.A692V	POLD1_uc002psc.3_Missense_Mutation_p.A692V|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.A718V	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	692					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CGGCAGCTGGCGCTGAAGGTG	0.672000								DNA_polymerases_(catalytic_subunits)					10	194					0	0	1	0	0
SPIB	6689	broad.mit.edu	37	19	50926144	50926144	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:50926144G>A	uc002psd.2	+	4	214	c.189G>A	c.(187-189)CCG>CCA	p.P63P	SPIB_uc002pse.2_Silent_p.P63P|SPIB_uc010ycc.1_Intron	NM_003121	NP_003112	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	63					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			lung(1)|kidney(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CCTTCGACCCGGCAGCAGCCG	0.662000													50	136					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52569526	52569526	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:52569526C>T	uc002pyl.1	-	5	1813	c.1261G>A	c.(1261-1263)GGA>AGA	p.G421R	ZNF841_uc010ydh.1_Missense_Mutation_p.G537R|ZNF841_uc010epk.1_Intron	NM_001136499	NP_001129971	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGTTTCTCTCCGGTATGAATT	0.398000													10	25					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55175317	55175317	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:55175317G>A	uc002qgp.2	+	3	538	c.176G>A	c.(175-177)CGT>CAT	p.R59H	LILRB4_uc002qgo.1_Missense_Mutation_p.R100H|LILRB4_uc002qgq.2_Missense_Mutation_p.R59H|LILRB4_uc010ers.1_5'UTR|LILRB4_uc002qgr.2_Missense_Mutation_p.R100H|LILRB4_uc010ert.2_Missense_Mutation_p.R100H|LILRB4_uc010eru.2_Missense_Mutation_p.R88H	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	59	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		CGGGAGTACCGTCTGGATAAA	0.587000													85	117					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451430	55451430	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:55451430C>T	uc002qih.3	-	4	833	c.757G>A	c.(757-759)GAT>AAT	p.D253N	NLRP7_uc002qig.3_Missense_Mutation_p.D253N|NLRP7_uc002qii.3_Missense_Mutation_p.D253N|NLRP7_uc010esk.2_Missense_Mutation_p.D253N|NLRP7_uc010esl.2_Missense_Mutation_p.D281N	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	253	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TCAAGGCCATCGACCACGAAC	0.567000													94	98					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55493635	55493635	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:55493635A>T	uc002qij.2	+	6	655	c.569A>T	c.(568-570)AAG>ATG	p.K190M	NLRP2_uc010yfp.1_Missense_Mutation_p.K167M|NLRP2_uc010esn.2_Missense_Mutation_p.K166M|NLRP2_uc010eso.2_Missense_Mutation_p.K187M|NLRP2_uc010esp.2_Missense_Mutation_p.K168M	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	190					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GAGAGATACAAGATGCTGATC	0.542000													56	168					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494882	55494882	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:55494882C>T	uc002qij.2	+	6	1902	c.1816C>T	c.(1816-1818)CTC>TTC	p.L606F	NLRP2_uc010yfp.1_Missense_Mutation_p.L583F|NLRP2_uc010esn.2_Missense_Mutation_p.L582F|NLRP2_uc010eso.2_Missense_Mutation_p.L603F|NLRP2_uc010esp.2_Missense_Mutation_p.L584F	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	606					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GCAGGAGCTCCTCGGCTGTCT	0.517000													31	39					0	0	1	0	0
SBK2	646643	broad.mit.edu	37	19	56041301	56041301	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:56041301C>T	uc010ygc.1	-	3	846	c.846G>A	c.(844-846)GCG>GCA	p.A282A		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	282	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0						GCTGGCCCGACGCCTGCCAGA	0.731000													4	6					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176021	57176021	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:57176021C>T	uc010ygo.1	-	2	612	c.612G>A	c.(610-612)GCG>GCA	p.A204A	ZNF835_uc010ygn.1_Silent_p.A182A	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GCCAGTGGGACGCCAGGTACG	0.716000													8	21					0	0	1	0	0
ZNF416	55659	broad.mit.edu	37	19	58084870	58084870	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:58084870C>T	uc002qpf.2	-	4	573	c.402G>A	c.(400-402)GCG>GCA	p.A134A	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		GGTGAAAGACCGCACATGCCC	0.502000													14	51					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58596148	58596148	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:58596148C>T	uc002qri.2	-	7	1746	c.1437G>A	c.(1435-1437)CCG>CCA	p.P479P	ZSCAN18_uc002qrj.3_Silent_p.P478P|ZSCAN18_uc010yhs.1_Silent_p.P343P|ZSCAN18_uc002qrh.2_Silent_p.P479P|ZSCAN18_uc010yht.1_Silent_p.P535P|ZSCAN18_uc002qrk.1_3'UTR|ZSCAN18_uc002qrl.2_3'UTR	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	479					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CGCGGGTGGACGGTTGGGGGC	0.726000													5	12					0	0	1	0	0
ZNF324B	388569	broad.mit.edu	37	19	58967425	58967425	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:58967425G>A	uc002qsv.1	+	4	1221	c.1114G>A	c.(1114-1116)GCA>ACA	p.A372T	ZNF324B_uc002qsu.1_Missense_Mutation_p.A362T|ZNF324B_uc010euq.1_Missense_Mutation_p.A372T	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	372	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TTATGCTTGCGCACAGTGTGG	0.657000													4	54					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1684083	1684083	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:1684083C>T	uc002qxa.2	-	7	676	c.612G>A	c.(610-612)GCG>GCA	p.A204A	PXDN_uc002qxb.1_Silent_p.A204A|PXDN_uc002qxc.1_Silent_p.A21A	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	204	LRRCT.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCAGCAAATCCGCCAACCACA	0.587000													22	19					0	0	1	0	0
ODC1	4953	broad.mit.edu	37	2	10582006	10582006	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:10582006G>A	uc010exg.1	-	10	1397	c.963C>T	c.(961-963)GGC>GGT	p.G321G	ODC1_uc002ran.1_Silent_p.G7G|ODC1_uc002rao.1_Silent_p.G321G|ODC1_uc010yjd.1_Silent_p.G191G	NM_002539	NP_002530	P11926	DCOR_HUMAN	ornithine decarboxylase 1	321					polyamine biosynthetic process|regulation of cellular amino acid metabolic process|response to virus	cytosol	ornithine decarboxylase activity|protein binding			ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.161)	Pyridoxal Phosphate(DB00114)|Spermine(DB00127)	ATCCATAGACGCCATCATTCA	0.378000													34	236					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25464537	25464537	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:25464537C>T	uc002rgc.2	-	17	2233	c.1976G>A	c.(1975-1977)CGC>CAC	p.R659H	DNMT3A_uc002rgd.2_Missense_Mutation_p.R659H|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.R470H	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	659					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCAATGTAGCGGTCCACCTG	0.627000			Mis|F|N|S		AML								31	28					0	0	1	0	0
HADHA	3030	broad.mit.edu	37	2	26414365	26414365	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:26414365C>T	uc002rgy.2	-	19	2263	c.2133G>A	c.(2131-2133)CCG>CCA	p.P711P	HADHA_uc010yks.1_Silent_p.P624P	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	711					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	CCAGACAAGGCGGGAAGCCAA	0.552000													47	43					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26700618	26700618	+	Splice_Site	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:26700618C>T	uc002rhk.2	-	19	2342	c.2215_splice	c.e19-1	p.E739_splice	OTOF_uc002rhh.2_Splice_Site|OTOF_uc002rhi.2_Silent_p.Q48Q|OTOF_uc002rhj.2_Splice_Site	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a						cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCTTCTTCCTGTGAATCAG	0.607000													23	42					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27529116	27529116	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:27529116G>A	uc002rjo.2	+	7	902	c.902G>A	c.(901-903)CGG>CAG	p.R301Q	TRIM54_uc002rjn.2_Missense_Mutation_p.R343Q	NM_187841	NP_912730	Q9BYV2	TRI54_HUMAN	ring finger protein 30 isoform 2	301	COS.				cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGCAGGGCGGCCGGAGCCA	0.642000													51	111					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28785936	28785936	+	Silent	SNP	C	T	T	rs147698393		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:28785936C>T	uc002rmb.1	+	18	1176	c.1176C>T	c.(1174-1176)AAC>AAT	p.N392N	PLB1_uc010ezj.1_Silent_p.N403N|PLB1_uc002rmc.2_Silent_p.N80N	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	392	4 X 308-326 AA approximate repeats.|2.|Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CTGACATCAACGTAATTGGAG	0.488000													20	85					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29240816	29240816	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:29240816G>A	uc010ezl.2	+	10	1705	c.1354G>A	c.(1354-1356)GCC>ACC	p.A452T	FAM179A_uc010ymm.1_Intron|FAM179A_uc002rmr.3_Intron	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	452							binding			ovary(3)|skin(1)	4						TGCCCGCCACGCCTCAGGTGG	0.672000													9	21					0	0	1	0	0
SRBD1	55133	broad.mit.edu	37	2	45812861	45812861	+	Missense_Mutation	SNP	C	T	T	rs145594682		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:45812861C>T	uc002rus.2	-	5	777	c.701G>A	c.(700-702)CGT>CAT	p.R234H		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	234					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			ATTAAAGAGACGAATGATGTT	0.323000													31	81					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46574124	46574124	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:46574124G>A	uc002ruv.2	+	2	627	c.139G>A	c.(139-141)GTG>ATG	p.V47M		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	47	Helix-loop-helix motif.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GCCCCACAGTGTGAGCTCCCA	0.617000													13	214					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043766	71043766	+	Silent	SNP	G	A	A	rs142908853		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:71043766G>A	uc002shf.2	-	4	824	c.747C>T	c.(745-747)AAC>AAT	p.N249N	CLEC4F_uc010yqv.1_Silent_p.N249N	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	249	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						CAGCATTAGCGTTCTTTAAAC	0.418000													31	88					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71753455	71753455	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:71753455C>T	uc002sie.2	+	12	1535	c.1159C>T	c.(1159-1161)CGG>TGG	p.R387W	DYSF_uc010feg.2_Missense_Mutation_p.R418W|DYSF_uc010feh.2_Missense_Mutation_p.R387W|DYSF_uc002sig.3_Missense_Mutation_p.R387W|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R387W|DYSF_uc010fef.2_Missense_Mutation_p.R418W|DYSF_uc010fei.2_Missense_Mutation_p.R418W|DYSF_uc010fek.2_Missense_Mutation_p.R419W|DYSF_uc010fej.2_Missense_Mutation_p.R388W|DYSF_uc010fel.2_Missense_Mutation_p.R388W|DYSF_uc010feo.2_Missense_Mutation_p.R419W|DYSF_uc010fem.2_Missense_Mutation_p.R388W|DYSF_uc010fen.2_Missense_Mutation_p.R419W|DYSF_uc002sif.2_Missense_Mutation_p.R388W	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	387	Cytoplasmic (Potential).|C2 3.		FRAED -> Y (in MMD1).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GAAGGTCTTCCGGGCCGAGGA	0.672000													83	246					0	0	1	0	0
CYP26B1	56603	broad.mit.edu	37	2	72359683	72359683	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:72359683G>A	uc002sih.1	-	6	1212	c.1212C>T	c.(1210-1212)CCC>CCT	p.P404P	CYP26B1_uc010yra.1_Silent_p.P387P|CYP26B1_uc010yrb.1_Silent_p.P329P	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	404					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						CTTTGAACACGGGCGCTGTGT	0.612000													23	37					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73717091	73717091	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:73717091C>T	uc002sje.1	+	12	8119	c.8008C>T	c.(8008-8010)CGA>TGA	p.R2670*	ALMS1_uc002sjf.1_Nonsense_Mutation_p.R2626*|ALMS1_uc002sjg.2_Nonsense_Mutation_p.R2056*|ALMS1_uc002sjh.1_Nonsense_Mutation_p.R2056*	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2668					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CAAAGGTCTTCGAATGCCATT	0.378000													95	176					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74595114	74595114	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:74595114G>A	uc002skx.2	-	17	2310	c.1999C>T	c.(1999-2001)CTA>TTA	p.L667L	DCTN1_uc002skv.2_Silent_p.L533L|DCTN1_uc002sku.2_Silent_p.L533L|DCTN1_uc002skw.1_Silent_p.L643L|DCTN1_uc010ffd.2_Silent_p.L647L|DCTN1_uc002sky.2_Silent_p.L630L	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	667					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						TAGCGGTGTAGCGTGGCCTGC	0.607000													25	94					0	0	1	0	0
TLX2	3196	broad.mit.edu	37	2	74742798	74742798	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:74742798C>A	uc002smb.1	+	2	762	c.439C>A	c.(439-441)CAC>AAC	p.H147N	TLX2_uc002sma.1_Missense_Mutation_p.P17Q	NM_016170	NP_057254	O43763	TLX2_HUMAN	T-cell leukemia homeobox 2	147						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCGCATAGGCCACCCCTACCA	0.652000													36	116					4.14481e-20	4.2706e-20	1	1	0
HK2	3099	broad.mit.edu	37	2	75107689	75107689	+	Silent	SNP	C	T	T	rs144796715		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:75107689C>T	uc002snd.2	+	10	3489	c.1563C>T	c.(1561-1563)GAC>GAT	p.D521D		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	521	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						CTACCCCGGACGGCACAGGTA	0.577000													9	31					0	0	1	0	0
TCF7L1	83439	broad.mit.edu	37	2	85531438	85531438	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:85531438C>T	uc002soy.2	+	7	896	c.822C>T	c.(820-822)CTC>CTT	p.L274L		NM_031283	NP_112573	Q9HCS4	TF7L1_HUMAN	HMG-box transcription factor TCF-3	274	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)|central_nervous_system(1)	3						ACCCCGCCCTCGCCATGAACG	0.592000													67	73					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88387390	88387390	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:88387390G>A	uc002ssr.2	+	3	326	c.324G>A	c.(322-324)GCG>GCA	p.A108A	SMYD1_uc002ssq.1_Intron	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GGCTGGCGGCGCGCATCATGT	0.493000													14	18					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100022891	100022891	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:100022891C>T	uc002tad.2	-	16	2722	c.2510G>A	c.(2509-2511)CGC>CAC	p.R837H	REV1_uc002tac.2_Missense_Mutation_p.R836H	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	837					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						AACTGATGGGCGACTGGGACA	0.453000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					22	41					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	103013337	103013337	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:103013337C>T	uc002tbw.3	+	11	1767	c.1617C>T	c.(1615-1617)TCC>TCT	p.S539S	IL18R1_uc010ywc.1_Silent_p.S538S|IL18R1_uc010ywd.1_Silent_p.S383S|IL18R1_uc010fiy.2_Silent_p.S539S	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	539	Cytoplasmic (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						CTGTTCTTTCCGAGTCTTAAT	0.413000													20	42					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109383056	109383056	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:109383056G>A	uc002tem.3	+	20	6187	c.6061G>A	c.(6061-6063)GAA>AAA	p.E2021K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2021	RanBD1 2.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TCAAATGCCCGAAAAAGTAGA	0.388000													325	373					0	0	1	0	0
POLR1B	84172	broad.mit.edu	37	2	113322007	113322007	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:113322007C>T	uc002thw.2	+	10	2257	c.1677C>T	c.(1675-1677)GAC>GAT	p.D559D	POLR1B_uc010fkn.2_Silent_p.D503D|POLR1B_uc002thx.2_Silent_p.D420D|POLR1B_uc010fko.2_Intron|POLR1B_uc010fkp.2_Translation_Start_Site|POLR1B_uc010yxn.1_Silent_p.D597D|POLR1B_uc002thy.2_Silent_p.D420D|POLR1B_uc010yxo.1_Silent_p.D336D	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	559					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						TCCTGCTGGACGGTGTCATGG	0.502000													74	135					0	0	1	0	0
TMEM177	80775	broad.mit.edu	37	2	120439264	120439264	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:120439264G>A	uc010flg.1	+	2	1308	c.835G>A	c.(835-837)GTC>ATC	p.V279I	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Missense_Mutation_p.V279I|TMEM177_uc002tmd.2_Missense_Mutation_p.V279I|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	279						integral to membrane				ovary(1)	1	Colorectal(110;0.196)					CGGGAACATCGTCCCCAGACA	0.582000													95	95					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136481617	136481617	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:136481617C>T	uc002tuo.2	+	26	3425	c.3055C>T	c.(3055-3057)CGG>TGG	p.R1019W	R3HDM1_uc010fni.2_Missense_Mutation_p.R1018W|R3HDM1_uc002tup.2_Missense_Mutation_p.R964W|R3HDM1_uc010zbh.1_Missense_Mutation_p.R767W	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	1019							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		CCGGTGGCTCCGGGACCCCCA	0.542000													93	80					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141816539	141816539	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:141816539G>A	uc002tvj.1	-	9	2293	c.1321C>T	c.(1321-1323)CGA>TGA	p.R441*	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	441	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.R441Q(1)		lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCATTAAATCGGTTTATCCTT	0.328000										TSP Lung(27;0.18)			7	89					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170022532	170022532	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:170022532G>A	uc002ues.2	-	62	11881	c.11668C>T	c.(11668-11670)CGG>TGG	p.R3890W		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3890	LDL-receptor class A 35.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTGTCACACCGGAAACGGTTT	0.388000													88	104					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170060607	170060607	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:170060607G>A	uc002ues.2	-	42	8103	c.7890C>T	c.(7888-7890)ACC>ACT	p.T2630T		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2630	LDL-receptor class B 29.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GCAAATTTGTGGTCATTGCAA	0.448000													69	294					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179412628	179412628	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:179412628C>T	uc010zfg.1	-	288	86245	c.86021G>A	c.(86020-86022)CGT>CAT	p.R28674H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R22369H|TTN_uc010zfi.1_Missense_Mutation_p.R22302H|TTN_uc010zfj.1_Missense_Mutation_p.R22177H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29601							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGGGCAGGACGACCACTGAT	0.448000													26	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179430304	179430304	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:179430304C>T	uc010zfg.1	-	275	73075	c.72851G>A	c.(72850-72852)CGT>CAT	p.R24284H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R17979H|TTN_uc010zfi.1_Missense_Mutation_p.R17912H|TTN_uc010zfj.1_Missense_Mutation_p.R17787H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25211							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCTTGACACGGAACTGATA	0.418000													74	193					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604439	179604439	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:179604439C>A	uc010zfh.1	-	46	13232	c.13008G>T	c.(13006-13008)ATG>ATT	p.M4336I	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.M4269I|TTN_uc010zfj.1_Missense_Mutation_p.M4144I|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAAAGAATCCATTTCTTCTT	0.388000													31	212					2.85442e-18	2.93659e-18	1	1	0
HECW2	57520	broad.mit.edu	37	2	197183524	197183524	+	Missense_Mutation	SNP	G	A	A	rs139251909		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:197183524G>A	uc002utm.1	-	9	2273	c.2090C>T	c.(2089-2091)TCG>TTG	p.S697L	HECW2_uc002utl.1_Missense_Mutation_p.S341L	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	697					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GGATTCCTGCGACCCTTCGGC	0.612000													6	110					0	0	1	0	0
BZW1	9689	broad.mit.edu	37	2	201683504	201683504	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:201683504G>A	uc010zhg.1	+	9	994	c.942G>A	c.(940-942)ATG>ATA	p.M314I	BZW1_uc002uwc.2_Missense_Mutation_p.M282I	NM_014670	NP_055485	Q7L1Q6	BZW1_HUMAN	basic leucine zipper and W2 domains 1	282	W2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	protein binding				0						AGGAGGAGATGAAAAAAAACA	0.373000													19	33					0	0	1	0	0
CD28	940	broad.mit.edu	37	2	204599561	204599561	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:204599561C>T	uc002vah.3	+	4	811	c.589C>T	c.(589-591)CGC>TGC	p.R197C	CD28_uc010zio.1_RNA|CD28_uc010ftx.2_Missense_Mutation_p.R78C|CD28_uc002vaj.3_RNA	NM_006139	NP_006130	P10747	CD28_HUMAN	CD28 antigen precursor	197	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity				0						CATGACTCCCCGCCGCCCCGG	0.597000													83	173					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215809802	215809802	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:215809802C>T	uc002vew.2	-	49	7486	c.7266G>A	c.(7264-7266)CCG>CCA	p.P2422P	ABCA12_uc002vev.2_Silent_p.P2104P|ABCA12_uc010zjn.1_Silent_p.P1349P	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2422	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GTTTCGACTTCGGATCCATGC	0.363000													26	29					0	0	1	0	0
ATIC	471	broad.mit.edu	37	2	216209588	216209588	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:216209588C>T	uc002vex.3	+	13	1488	c.1314C>T	c.(1312-1314)AAC>AAT	p.N438N	ATIC_uc010zjo.1_Silent_p.N379N|ATIC_uc002vey.3_Silent_p.N437N	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	438					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	ACGCCAAGAACGGGCAGGTAA	0.488000			T	ALK	ALCL								28	61					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220334066	220334066	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:220334066G>A	uc010fwg.2	+	13	3680	c.3680G>A	c.(3679-3681)CGC>CAC	p.R1227H		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1227	Ig-like 6.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AATGGCCACCGCATCCAGAGC	0.642000													36	37					0	0	1	0	0
CCL20	6364	broad.mit.edu	37	2	228678691	228678691	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:228678691G>A	uc002vpl.2	+	1	134	c.64G>A	c.(64-66)GGC>AGC	p.G22S	CCL20_uc002vpm.2_Missense_Mutation_p.G22S	NM_004591	NP_004582	P78556	CCL20_HUMAN	chemokine (C-C motif) ligand 20 isoform 1	22					cell-cell signaling|chemotaxis|defense response to bacterium|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity				0		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;7.3e-11)|all cancers(144;4.13e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		CCACCTCTGCGGCGAATCAGA	0.473000													24	258					0	0	1	0	0
DIS3L2	129563	broad.mit.edu	37	2	233128091	233128091	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:233128091G>A	uc010fxz.2	+	13	1876	c.1600G>A	c.(1600-1602)GGA>AGA	p.G534R	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	534							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		GAATCTCCACGGAATTGCCAA	0.522000													17	121					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233405401	233405401	+	Silent	SNP	G	A	A	rs149931943		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:233405401G>A	uc002vsx.1	+	4	351	c.330G>A	c.(328-330)CCG>CCA	p.P110P	CHRNG_uc010fyd.2_Silent_p.P110P|CHRNG_uc010fye.1_Silent_p.P110P	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	110	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		TGTGGCGGCCGGATATCGTGC	0.642000													21	13					0	0	1	0	0
DGKD	8527	broad.mit.edu	37	2	234371341	234371341	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:234371341G>A	uc002vui.1	+	26	3158	c.3146G>A	c.(3145-3147)CGC>CAC	p.R1049H	DGKD_uc002vuj.1_Missense_Mutation_p.R1005H|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	1049					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	AGAGCTCTGCGCAGTGAGACG	0.597000													38	249					0	0	1	0	0
UGT1A8	54576	broad.mit.edu	37	2	234526381	234526381	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:234526381A>G	uc002vup.2	+	1	91	c.28A>G	c.(28-30)ATT>GTT	p.I10V	UGT1A8_uc010zmv.1_Missense_Mutation_p.I10V	NM_019076	NP_061949	Q9HAW9	UD18_HUMAN	UDP glycosyltransferase 1 family, polypeptide A8	10					drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		GACCAGCCCCATTCCCCTATG	0.572000													57	64					0	0	1	0	0
DNAJB3	414061	broad.mit.edu	37	2	234652392	234652392	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:234652392C>T	uc002vuz.2	-	1	270	c.171G>A	c.(169-171)TCG>TCA	p.S57S	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron	NM_001001394	NP_001001394	Q8WWF6	DNJB3_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 3	57	J.				protein folding		heat shock protein binding|unfolded protein binding				0						TCTTGGCGTCCGACAACACCT	0.627000													43	348					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	239975226	239975226	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:239975226C>T	uc002vyk.3	-	26	3937	c.3145G>A	c.(3145-3147)GAG>AAG	p.E1049K	HDAC4_uc010fyy.2_Missense_Mutation_p.E1006K	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	1049	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		TCTTCGTTCTCGCAAGTCTGA	0.662000													53	63					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241468876	241468876	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:241468876G>A	uc002vyz.1	-	4	493	c.264C>T	c.(262-264)CCC>CCT	p.P88P	ANKMY1_uc002vza.1_Intron|ANKMY1_uc010fzd.1_Silent_p.P177P|ANKMY1_uc002vzb.1_Intron|ANKMY1_uc002vzc.1_Intron|ANKMY1_uc002vzd.1_Intron|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Intron	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	88	MORN 3.						zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GGCTGCCATCGGGGTAGGTCT	0.602000													27	50					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241570136	241570136	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:241570136G>A	uc002vzs.1	+	1	1342	c.767G>A	c.(766-768)CGC>CAC	p.R256H	GPR35_uc010fzh.1_Missense_Mutation_p.R287H|GPR35_uc010fzi.1_Missense_Mutation_p.R287H	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	256	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		ACGATCCGTCGCGCCCTGTAC	0.622000													124	145					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241680733	241680733	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:241680733G>A	uc002vzy.2	-	33	3545	c.3399C>T	c.(3397-3399)TAC>TAT	p.Y1133Y	KIF1A_uc010fzk.2_Silent_p.Y1234Y|KIF1A_uc002vzz.1_Silent_p.Y1234Y	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1133					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CCAGCAGGTCGTACTTGCAGT	0.662000													11	14					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242148714	242148714	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:242148714C>T	uc002wax.2	+	12	1357	c.1254C>T	c.(1252-1254)TTC>TTT	p.F418F		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	418	Extracellular (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						GCCGGCTGTTCGACCACGGCG	0.463000													4	12					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242169651	242169651	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:242169651C>A	uc002waz.2	-	26	3736	c.3508G>T	c.(3508-3510)GAC>TAC	p.D1170Y	HDLBP_uc002wba.2_Missense_Mutation_p.D1170Y|HDLBP_uc002wbb.2_Missense_Mutation_p.D1122Y	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	1170	KH 14.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CAGTTGGGGTCTGGGGCTCCG	0.557000													5	118					0.00198382	0.00199853	1	1	0
STK25	10494	broad.mit.edu	37	2	242437037	242437037	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:242437037G>A	uc002wbm.2	-	9	1369	c.1098C>T	c.(1096-1098)TTC>TTT	p.F366F	STK25_uc002wbk.2_Silent_p.F185F|STK25_uc002wbl.2_3'UTR|STK25_uc002wbn.2_Silent_p.F366F|STK25_uc002wbo.2_Silent_p.F289F|STK25_uc010zos.1_Silent_p.F272F|STK25_uc010zot.1_Silent_p.F292F|STK25_uc002wbp.2_Silent_p.F366F|STK25_uc010fzo.2_Silent_p.F289F|STK25_uc010zou.1_Silent_p.F272F|STK25_uc010zov.1_Silent_p.F272F	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	366					response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TCACCTCTCCGAAGACGGGCC	0.657000													101	103					0	0	1	0	0
C2orf85	285093	broad.mit.edu	37	2	242815361	242815361	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:242815361G>A	uc010fzu.1	+	2	1677	c.1654G>A	c.(1654-1656)GTG>ATG	p.V552M		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	552	Helical; (Potential).					integral to membrane				ovary(1)	1						GTCCATGACCGTGTGCGTCTT	0.662000													101	214					0	0	1	0	0
FAM113A	64773	broad.mit.edu	37	20	2820527	2820527	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:2820527C>T	uc002wgz.1	-	2	529	c.32G>A	c.(31-33)CGC>CAC	p.R11H	FAM113A_uc002whb.1_5'UTR|FAM113A_uc002wha.1_5'UTR|FAM113A_uc010zqa.1_5'UTR|FAM113A_uc002whc.1_Missense_Mutation_p.R11H|VPS16_uc002whe.2_5'Flank|VPS16_uc002whf.2_5'Flank|VPS16_uc002whd.2_5'Flank	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773	11							hydrolase activity|protein binding			ovary(2)	2						CAGCGGGCGGCGCGGCTCCTC	0.637000													35	42					0	0	1	0	0
BFSP1	631	broad.mit.edu	37	20	17489628	17489628	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:17489628G>A	uc002wpo.2	-	5	680	c.641C>T	c.(640-642)ACG>ATG	p.T214M	BFSP1_uc002wpp.2_Missense_Mutation_p.T89M|BFSP1_uc010zrn.1_Missense_Mutation_p.T75M|BFSP1_uc010zro.1_Missense_Mutation_p.T75M	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	214	Rod.|Coil 2.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						CTCCCGCTCCGTCAGGAGCTT	0.612000													11	17					0	0	1	0	0
PLAGL2	5326	broad.mit.edu	37	20	30789887	30789887	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:30789887C>T	uc002wxn.2	-	2	312	c.95G>A	c.(94-96)CGG>CAG	p.R32Q		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	32						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTCCGCCTCCCGGCCCCGAGG	0.567000													30	111					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31368261	31368261	+	Silent	SNP	G	A	A	rs138805251		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:31368261G>A	uc002wyc.2	+	2	453	c.132G>A	c.(130-132)CCG>CCA	p.P44P	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Silent_p.P44P|DNMT3B_uc002wye.2_Silent_p.P44P|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Silent_p.P44P|DNMT3B_uc010zua.1_Silent_p.P44P|DNMT3B_uc002wyf.2_Silent_p.P56P	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	44	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						TCCGCACCCCGGAGATCAGAG	0.652000													13	39					0	0	1	0	0
C20orf186	149954	broad.mit.edu	37	20	31671678	31671678	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:31671678G>A	uc010zue.1	+	3	690	c.675G>A	c.(673-675)ACG>ACA	p.T225T		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	225	Gly-rich.					cytoplasm|extracellular region	lipid binding				0						AAGGCATCACGGGGTAAGGAG	0.627000													44	52					0	0	1	0	0
DYNLRB1	83658	broad.mit.edu	37	20	33122560	33122560	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:33122560C>T	uc002xal.2	+	3	268	c.208C>T	c.(208-210)CGA>TGA	p.R70*	DYNLRB1_uc010zuk.1_Nonsense_Mutation_p.R70*|DYNLRB1_uc002xam.2_RNA|DYNLRB1_uc002xan.2_RNA	NM_014183	NP_054902	Q9NP97	DLRB1_HUMAN	Roadblock-1	70					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity				0						CACCTTCCTTCGAATTCGCTC	0.537000													45	58					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34770234	34770234	+	Silent	SNP	G	A	A	rs139137163	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:34770234G>A	uc002xfb.2	+	6	702	c.531G>A	c.(529-531)CCG>CCA	p.P177P	EPB41L1_uc002xeu.2_Silent_p.P115P|EPB41L1_uc010zvo.1_Silent_p.P177P|EPB41L1_uc002xev.2_Silent_p.P177P|EPB41L1_uc002xew.2_Silent_p.P80P|EPB41L1_uc002xex.2_Silent_p.P146P|EPB41L1_uc002xey.2_Silent_p.P177P|EPB41L1_uc002xez.2_Silent_p.P115P	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	177	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					AGTTCTACCCGCCTGATCCTG	0.582000													38	69					0	0	1	0	0
DHX35	60625	broad.mit.edu	37	20	37659354	37659354	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:37659354C>T	uc002xjh.2	+	20	1902	c.1891C>T	c.(1891-1893)CGT>TGT	p.R631C	DHX35_uc010zwa.1_Missense_Mutation_p.R476C|DHX35_uc010zwb.1_Missense_Mutation_p.R476C|DHX35_uc010zwc.1_Missense_Mutation_p.R600C	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	631						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				AAGGACCATCCGTGATGACCA	0.438000													40	100					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44838993	44838993	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:44838993G>A	uc002xrm.2	-	6	1640	c.1239C>T	c.(1237-1239)GTC>GTT	p.V413V	CDH22_uc010ghk.1_Silent_p.V413V|CDH22_uc002xrn.1_Silent_p.V164V	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	413	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				TCACCACGCCGACCAGGGAGC	0.771000													6	4					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45217829	45217829	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:45217829C>T	uc002xsf.1	-	7	1024	c.986G>A	c.(985-987)CGG>CAG	p.R329Q	SLC13A3_uc010ghn.1_Missense_Mutation_p.R298Q|SLC13A3_uc010zxw.1_Missense_Mutation_p.R279Q|SLC13A3_uc002xsg.1_Missense_Mutation_p.R282Q|SLC13A3_uc010gho.1_Missense_Mutation_p.R282Q|SLC13A3_uc010zxx.1_Missense_Mutation_p.R231Q	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	329	Cytoplasmic (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	GTATTCTTCCCGAATTACAGC	0.502000													24	130					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47266679	47266679	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:47266679C>T	uc002xtw.1	-	24	2906	c.2883G>A	c.(2881-2883)CCG>CCA	p.P961P	PREX1_uc002xtv.1_Silent_p.P258P	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	961					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGCCACACAGCGGGTGGGGCT	0.592000													78	163					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60503309	60503309	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:60503309C>T	uc002ybn.1	+	12	1847	c.1833C>T	c.(1831-1833)AAC>AAT	p.N611N	CDH4_uc002ybp.1_Silent_p.N537N	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	611	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			TCAACGACAACGCCCCTGAGC	0.627000													82	354					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60504690	60504690	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:60504690C>T	uc002ybn.1	+	13	2043	c.2029C>T	c.(2029-2031)CGC>TGC	p.R677C	CDH4_uc002ybp.1_Missense_Mutation_p.R603C	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	677	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			ACTCAGCTTGCGCATCCTGTA	0.532000													37	105					0	0	1	0	0
TAF4	6874	broad.mit.edu	37	20	60574065	60574065	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:60574065G>A	uc002ybs.2	-	12	2887	c.2887C>T	c.(2887-2889)CGG>TGG	p.R963W		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	963					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			AGGATCTCCCGCTCCTGCTCA	0.557000													178	279					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60905854	60905854	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:60905854C>T	uc002ycq.2	-	30	3864	c.3797G>A	c.(3796-3798)CGG>CAG	p.R1266Q		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1266	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGGGGGGCCGAGGTCGGGG	0.697000													3	7					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61288352	61288352	+	Silent	SNP	G	A	A	rs147575435	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:61288352G>A	uc002ydb.1	+	2	751	c.546G>A	c.(544-546)ACG>ACA	p.T182T	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	182	Helical; Name=3; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			TTATGGGCACGGGGTCGCTGG	0.687000													13	103					0	0	1	0	0
PRIC285	85441	broad.mit.edu	37	20	62195519	62195519	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:62195519C>T	uc002yfm.2	-	9	5548	c.4656G>A	c.(4654-4656)CTG>CTA	p.L1552L	PRIC285_uc002yfl.1_Silent_p.L983L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1552					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GCTGCCACCGCAGAGGCGTGA	0.647000													12	35					0	0	1	0	0
C20orf135	140701	broad.mit.edu	37	20	62493215	62493215	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:62493215C>T	uc002ygx.1	+	1	650	c.322C>T	c.(322-324)CGC>TGC	p.R108C		NM_080622	NP_542189	Q9H3Z7	ABHGB_HUMAN	hypothetical protein LOC140701	108							hydrolase activity				0	all_cancers(38;1.77e-12)|all_epithelial(29;3.12e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					CTCGCTGGGCCGCTGGCTCGT	0.741000													12	10					0	0	1	0	0
SON	6651	broad.mit.edu	37	21	34923567	34923567	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr21:34923567C>T	uc002yse.1	+	3	2079	c.2030C>T	c.(2029-2031)TCG>TTG	p.S677L	SON_uc002ysb.1_Missense_Mutation_p.S677L|SON_uc002ysc.2_Missense_Mutation_p.S677L|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	677					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GAGGTGCCCTCGACGACAGCG	0.557000													27	97					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43230535	43230535	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr21:43230535C>T	uc002yzq.1	-	28	3836	c.3725G>A	c.(3724-3726)CGA>CAA	p.R1242Q	PRDM15_uc002yzo.2_Missense_Mutation_p.R913Q|PRDM15_uc002yzp.2_Missense_Mutation_p.R933Q|PRDM15_uc002yzr.1_Missense_Mutation_p.R933Q	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1242	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGCATGTGTCGGCTCATGGA	0.682000													29	27					0	0	1	0	0
ICOSLG	23308	broad.mit.edu	37	21	45651221	45651221	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr21:45651221G>A	uc002zee.2	-	5	938	c.804C>T	c.(802-804)GTC>GTT	p.V268V	ICOSLG_uc011afc.1_Silent_p.V178V|ICOSLG_uc002zef.2_Silent_p.V151V|ICOSLG_uc010gpp.1_Silent_p.V268V	NM_015259	NP_056074	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand precursor	268	Helical; (Potential).				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding				0				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		CCACCGCCACGACCACAAGCA	0.567000													52	72					0	0	1	0	0
SLC19A1	6573	broad.mit.edu	37	21	46951531	46951531	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr21:46951531C>T	uc002zhl.1	-	3	840	c.721G>A	c.(721-723)GCC>ACC	p.A241T	SLC19A1_uc010gpy.1_Missense_Mutation_p.A241T|SLC19A1_uc011aft.1_Missense_Mutation_p.A201T|SLC19A1_uc002zhm.1_Missense_Mutation_p.A241T|SLC19A1_uc010gpz.1_Missense_Mutation_p.A120T	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	241	Cytoplasmic (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		ACCCGCAGGGCGTGTCCCAGC	0.716000													69	60					0	0	1	0	0
SLC19A1	6573	broad.mit.edu	37	21	46951822	46951822	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr21:46951822C>T	uc002zhl.1	-	3	549	c.430G>A	c.(430-432)GTG>ATG	p.V144M	SLC19A1_uc010gpy.1_Missense_Mutation_p.V144M|SLC19A1_uc011aft.1_Missense_Mutation_p.V104M|SLC19A1_uc002zhm.1_Missense_Mutation_p.V144M|SLC19A1_uc010gpz.1_Missense_Mutation_p.V23M	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	144	Helical; (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GCGGGCCGCACGAGAGAGAAG	0.667000													5	9					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47423450	47423450	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr21:47423450C>T	uc002zhu.1	+	35	2712	c.2610C>T	c.(2608-2610)GAC>GAT	p.D870D	COL6A1_uc010gqd.1_Silent_p.D201D|COL6A1_uc002zhv.1_Silent_p.D201D|COL6A1_uc002zhw.1_Translation_Start_Site	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	870	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CCGCCCACGACGTGCGGGTGG	0.711000													21	65					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47916995	47916995	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr21:47916995G>A	uc002zjo.2	+	4	561	c.378G>A	c.(376-378)TCG>TCA	p.S126S	DIP2A_uc011afy.1_Silent_p.S62S|DIP2A_uc011afz.1_Silent_p.S126S|DIP2A_uc002zjl.2_Silent_p.S126S|DIP2A_uc002zjm.2_Silent_p.S126S|DIP2A_uc010gql.2_Silent_p.S126S|DIP2A_uc002zjn.2_Silent_p.S126S	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	126					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		TTGTGCATTCGTCTGTGGAAA	0.453000													17	18					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17589817	17589817	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:17589817G>A	uc002zly.2	+	13	1841	c.1708G>A	c.(1708-1710)GCC>ACC	p.A570T	IL17RA_uc010gqt.2_Missense_Mutation_p.A518T	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	570	Cytoplasmic (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		GCTCCGCGCCGCCCTGGACAG	0.677000													7	32					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18387494	18387494	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:18387494C>T	uc002zng.3	-	3	729	c.376G>A	c.(376-378)GTC>ATC	p.V126I	MICAL3_uc011agl.1_Missense_Mutation_p.V126I|MICAL3_uc002znh.2_Missense_Mutation_p.V126I|MICAL3_uc002znj.1_5'Flank|MICAL3_uc002znk.1_Missense_Mutation_p.V126I|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Missense_Mutation_p.V126I|MICAL3_uc011agm.1_Missense_Mutation_p.V126I	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	126						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		AGATGCAAGACGTTGTTGCGG	0.522000													36	254					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19960526	19960526	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:19960526G>A	uc002zqz.2	-	15	2743	c.2472C>T	c.(2470-2472)CAC>CAT	p.H824H	ARVCF_uc002zqy.2_Silent_p.H340H	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	824	ARM 10.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TCTGCAGCACGTGTGACGCCG	0.672000													49	164					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21082106	21082106	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:21082106G>A	uc002zsz.3	-	40	4786	c.4555C>T	c.(4555-4557)CGG>TGG	p.R1519W	PI4KA_uc002zsy.3_Missense_Mutation_p.R329W	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1519					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GGGTCCAACCGAACGAGACGG	0.547000													46	77					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22048118	22048118	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:22048118C>T	uc010gtj.1	+	16	1269	c.1153C>T	c.(1153-1155)CGC>TGC	p.R385C	PPIL2_uc002zvh.3_Missense_Mutation_p.R385C|PPIL2_uc002zvi.3_Missense_Mutation_p.R385C|PPIL2_uc002zvg.3_Missense_Mutation_p.R385C|PPIL2_uc011aij.1_Missense_Mutation_p.R364C|PPIL2_uc002zvk.3_Missense_Mutation_p.R131C	NM_148175	NP_680480	Q13356	PPIL2_HUMAN	peptidylprolyl isomerase-like 2 isoform a	385	PPIase cyclophilin-type.				blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			ovary(2)	2	Colorectal(54;0.105)					CATCACGTTTCGCTCCTGTGC	0.602000													116	152					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24479228	24479228	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:24479228G>A	uc002zzi.1	+	20	2923	c.2796G>A	c.(2794-2796)ACG>ACA	p.T932T	CABIN1_uc002zzj.1_Silent_p.T882T|CABIN1_uc002zzl.1_Silent_p.T932T	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	932					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CTGAAGACACGCACCCTTACA	0.582000													40	50					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24581087	24581087	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:24581087G>A	uc002zzn.1	+	6	852	c.808G>A	c.(808-810)GAC>AAC	p.D270N		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	270	Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CTGGACCAACGACCACGCACT	0.672000													28	52					0	0	1	0	0
ADRBK2	157	broad.mit.edu	37	22	26118335	26118335	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:26118335C>T	uc003abx.3	+	21	2132	c.1985C>T	c.(1984-1986)CCG>CTG	p.P662L	ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	662							ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	CGTCGTGCCCCGAAGTTCCTC	0.542000													40	135					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164580	26164580	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:26164580A>G	uc003abz.1	+	4	947	c.697A>G	c.(697-699)AAA>GAA	p.K233E	MYO18B_uc003aca.1_Missense_Mutation_p.K114E|MYO18B_uc010guy.1_Missense_Mutation_p.K114E|MYO18B_uc010guz.1_Missense_Mutation_p.K114E|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	233						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGCACTGAAAAAAGGCGAGGA	0.617000													4	16					0	0	1	0	0
INPP5J	27124	broad.mit.edu	37	22	31522443	31522443	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:31522443C>T	uc003aju.3	+	3	1445	c.1353C>T	c.(1351-1353)GAC>GAT	p.D451D	INPP5J_uc010gwf.2_Silent_p.D451D|INPP5J_uc003ajv.3_Silent_p.D84D|INPP5J_uc003ajs.3_Silent_p.D84D|INPP5J_uc011alk.1_Silent_p.D384D|INPP5J_uc010gwg.2_Silent_p.D16D|INPP5J_uc003ajw.2_Translation_Start_Site|INPP5J_uc003ajt.3_Silent_p.D83D|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	451	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						GCGGTGGTGACGACAGCGACG	0.657000													109	191					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	31976293	31976293	+	Silent	SNP	C	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:31976293C>A	uc003ale.2	+	12	1584	c.1191C>A	c.(1189-1191)ACC>ACA	p.T397T	SFI1_uc003ald.1_Silent_p.T373T|SFI1_uc003alf.2_Intron|SFI1_uc003alg.2_Silent_p.T315T|SFI1_uc011alp.1_Silent_p.T315T|SFI1_uc011alq.1_Intron|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	397					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						ACAATGTGACCCACGCTCATC	0.453000													5	74					0.184627	0.1849	1	1	0
SFI1	9814	broad.mit.edu	37	22	32000374	32000374	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:32000374C>T	uc003ale.2	+	19	2354	c.1961C>T	c.(1960-1962)GCG>GTG	p.A654V	SFI1_uc003ald.1_Missense_Mutation_p.A630V|SFI1_uc003alf.2_Missense_Mutation_p.A623V|SFI1_uc003alg.2_Missense_Mutation_p.A572V|SFI1_uc011alp.1_Missense_Mutation_p.A572V|SFI1_uc011alq.1_Missense_Mutation_p.A599V|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_Intron	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	654	Interaction with CETN2.				G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						CTGCACAGGGCGCTGCAGGCA	0.602000											OREG0003526	type=REGULATORY REGION|Gene=SFI1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	3	7					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36122590	36122590	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:36122590G>A	uc003aof.2	+	3	475	c.475G>A	c.(475-477)GCA>ACA	p.A159T		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	159					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						TTTGGCCCTAGCACCTGTGAC	0.547000													7	177					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37770333	37770333	+	Silent	SNP	G	A	A	rs144585839		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:37770333G>A	uc003asq.3	-	3	2028	c.1242C>T	c.(1240-1242)GCC>GCT	p.A414A		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	414	Helical; (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					AGTAGTACACGGCTCCCAGCA	0.607000													56	115					0	0	1	0	0
MFNG	4242	broad.mit.edu	37	22	37882079	37882079	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:37882079G>A	uc003ass.1	-	1	307	c.137C>T	c.(136-138)CCG>CTG	p.P46L	MFNG_uc011ani.1_5'UTR|MFNG_uc011anj.1_Missense_Mutation_p.P46L|CARD10_uc003ast.1_Intron	NM_002405	NP_002396	O00587	MFNG_HUMAN	O-fucosylpeptide	46	Lumenal (Potential).				pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			lung(1)	1	Melanoma(58;0.0574)					AGGGGGCCCCGGGTTCGGCTG	0.632000													22	111					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38051660	38051660	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:38051660G>A	uc003ati.2	+	18	2186	c.2075G>A	c.(2074-2076)CGC>CAC	p.R692H	SH3BP1_uc003atg.1_Intron|SH3BP1_uc003ath.1_Intron|SH3BP1_uc003atj.1_Intron|SH3BP1_uc003atk.1_Intron|uc003atl.1_Intron	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	692					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCTCAGCCCCGCCCCAGGAGC	0.677000													8	7					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40043868	40043868	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:40043868G>A	uc003ayc.2	+	9	1504	c.1504G>A	c.(1504-1506)GGA>AGA	p.G502R	CACNA1I_uc003ayd.2_Intron|CACNA1I_uc003aye.2_Missense_Mutation_p.G417R|CACNA1I_uc003ayf.2_Intron	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	502	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	gaGACATCTCGGAAGCCGGCA	0.353000													29	66					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40662440	40662440	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:40662440C>T	uc011aor.1	+	5	2417	c.2206C>T	c.(2206-2208)CGC>TGC	p.R736C	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Missense_Mutation_p.R736C|TNRC6B_uc003ayo.2_Missense_Mutation_p.R540C	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	736					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						GGGAGGTGGACGCCAGCCCAA	0.502000													9	21					0	0	1	0	0
SGSM3	27352	broad.mit.edu	37	22	40803287	40803287	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:40803287C>T	uc003ayu.1	+	12	1532	c.1323C>T	c.(1321-1323)CGC>CGT	p.R441R	SGSM3_uc011aos.1_Silent_p.R374R|SGSM3_uc011aot.1_Silent_p.R378R|SGSM3_uc010gyd.1_Silent_p.R484R	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	441					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						CCATCCTGCGCGTGGCACGCC	0.617000													43	85					0	0	1	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41620136	41620136	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:41620136G>A	uc003azo.2	+	9	1109	c.1055G>A	c.(1054-1056)CGC>CAC	p.R352H	L3MBTL2_uc010gyi.1_Missense_Mutation_p.R261H|L3MBTL2_uc003azn.2_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	352	MBT 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						ATCGGGGGTCGCCTACGGCTC	0.607000													45	88					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45914668	45914668	+	Splice_Site	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:45914668G>A	uc003bgj.1	+	2	332	c.185_splice	c.e2+1	p.R62_splice	FBLN1_uc003bgg.1_Splice_Site_p.R62_splice|FBLN1_uc003bgh.2_Splice_Site_p.R62_splice|FBLN1_uc010gzz.2_Splice_Site_p.R62_splice|FBLN1_uc003bgi.1_Splice_Site_p.R62_splice	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D						interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		AAGAATGCAGGTACGTTTGCC	0.567000													14	14					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46776725	46776725	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:46776725G>A	uc003bhw.1	-	22	7216	c.7216C>T	c.(7216-7218)CGA>TGA	p.R2406*	CELSR1_uc011arc.1_Nonsense_Mutation_p.R727*	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2406	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGCTTGGTTCGCTCCTCCACC	0.667000													23	102					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46806347	46806347	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:46806347G>A	uc003bhw.1	-	7	4881	c.4881C>T	c.(4879-4881)GAC>GAT	p.D1627D	CELSR1_uc011arc.1_5'Flank	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1627	Extracellular (Potential).|Laminin G-like 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CATTTTTGCCGTCGACTGACA	0.632000													76	132					0	0	1	0	0
SAPS2	9701	broad.mit.edu	37	22	50882544	50882544	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:50882544C>T	uc003blb.1	+	24	3272	c.2850C>T	c.(2848-2850)GAC>GAT	p.D950D	SAPS2_uc003bky.1_Silent_p.D917D|SAPS2_uc003bkz.1_Silent_p.D916D|SAPS2_uc003blc.2_Silent_p.D943D|SAPS2_uc003bla.1_Silent_p.D917D|SAPS2_uc003bld.1_Silent_p.D476D	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	950						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		TGACAAAGGACGGGTGAGCAG	0.667000													44	98					0	0	1	0	0
TYMP	1890	broad.mit.edu	37	22	50967656	50967656	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:50967656C>T	uc003bmb.3	-	2	446	c.326G>A	c.(325-327)CGC>CAC	p.R109H	TYMP_uc003bmc.3_Missense_Mutation_p.R109H|TYMP_uc003bmd.3_Missense_Mutation_p.R109H|TYMP_uc010hbd.2_Missense_Mutation_p.R109H|TYMP_uc003bme.3_Missense_Mutation_p.R109H|TYMP_uc003bmf.3_Missense_Mutation_p.R109H|TYMP_uc011arz.1_Missense_Mutation_p.R109H	NM_001113756	NP_001107228	P19971	TYPH_HUMAN	endothelial cell growth factor 1	109					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			ovary(1)	1		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	AAGCTGCTGGCGCCAGGCCTC	0.642000													38	87					0	0	1	0	0
NR2C2	7182	broad.mit.edu	37	3	15065637	15065637	+	Silent	SNP	T	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:15065637T>A	uc003bzj.3	+	7	937	c.720T>A	c.(718-720)CTT>CTA	p.L240L	NR2C2_uc003bzi.2_Silent_p.L259L	NM_003298	NP_003289	P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	240					cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						CAGGTCTTCTTGATCCAGGGA	0.438000													31	91					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36779958	36779958	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:36779958C>T	uc003cgi.2	-	2	684	c.193G>A	c.(193-195)GAA>AAA	p.E65K		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	65						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						CCTGCAACTTCGCTGCAGCTC	0.612000													180	45					0	0	1	0	0
MLH1	4292	broad.mit.edu	37	3	37038172	37038172	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:37038172A>C	uc003cgl.2	+	2	239	c.179A>C	c.(178-180)CAG>CCG	p.Q60P	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_Intron|MLH1_uc010hge.2_Missense_Mutation_p.Q60P|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_5'UTR|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	60					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						AAGTTGATTCAGATCCAAGAC	0.413000		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				51	11					0	0	1	0	0
PRSS50	29122	broad.mit.edu	37	3	46759103	46759103	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:46759103G>A	uc003cqe.1	-	2	190	c.131C>T	c.(130-132)CCG>CTG	p.P44L	PRSS50_uc003cqf.1_Intron	NM_013270	NP_037402	Q9UI38	TSP50_HUMAN	testes-specific protease 50 precursor	44					proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity				0						CAGCGCCCCCGGGGCTTCCCC	0.706000													36	13					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47891361	47891361	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:47891361C>T	uc003cru.2	+	22	3762	c.3336C>T	c.(3334-3336)GAC>GAT	p.D1112D	DHX30_uc003crt.2_Silent_p.D1073D	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	1112						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CCTCAGATGACGGGCGCCGGG	0.692000											OREG0015550	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	150					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48422276	48422276	+	Missense_Mutation	SNP	G	A	A	rs144607752	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:48422276G>A	uc003csr.2	+	8	1045	c.859G>A	c.(859-861)GCC>ACC	p.A287T	FBXW12_uc010hjv.2_Missense_Mutation_p.A268T|FBXW12_uc003css.2_Missense_Mutation_p.A217T|FBXW12_uc010hjw.2_Missense_Mutation_p.A186T	NM_207102	NP_996985	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12 isoform	287											0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ATGTGCCAGCGCCTGCTGGAC	0.443000													116	35					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49699985	49699985	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:49699985C>T	uc003cxe.3	+	6	10821	c.10707C>T	c.(10705-10707)TCC>TCT	p.S3569S		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3569					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCGTGGTTTCCGACAGCGAAG	0.597000													71	25					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50224060	50224060	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:50224060G>A	uc003cyj.2	+	18	2026	c.1828G>A	c.(1828-1830)GTG>ATG	p.V610M	SEMA3F_uc003cyk.2_Missense_Mutation_p.V579M	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	610	Ig-like C2-type.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		CAAGAATGCCGTGGAGTCTGT	0.627000													22	68					0	0	1	0	0
IFRD2	7866	broad.mit.edu	37	3	50326252	50326252	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:50326252G>A	uc011bdp.1	-	9	1323	c.1194C>T	c.(1192-1194)CGC>CGT	p.R398R	IFRD2_uc003czb.2_Silent_p.R500R	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	398							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCAGCACGGCGCGGAAAGTAG	0.602000													26	9					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52380763	52380763	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:52380763C>T	uc011bef.1	+	11	2193	c.1932C>T	c.(1930-1932)GAC>GAT	p.D644D	DNAH1_uc003ddt.1_Silent_p.D644D	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	644	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCTGGGGTGACGACTTAATTA	0.602000													25	7					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52407044	52407044	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:52407044C>T	uc011bef.1	+	44	7221	c.6960C>T	c.(6958-6960)GGC>GGT	p.G2320G		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2320	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGGACCACGGCGGCTGGTACG	0.542000													10	44					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58108831	58108831	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:58108831C>T	uc003djj.2	+	21	3303	c.3138C>T	c.(3136-3138)CAC>CAT	p.H1046H	FLNB_uc010hne.2_Silent_p.H1046H|FLNB_uc003djk.2_Silent_p.H1046H|FLNB_uc010hnf.2_Silent_p.H1046H|FLNB_uc003djl.2_Silent_p.H877H|FLNB_uc003djm.2_Silent_p.H877H	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1046	Filamin 9.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TGAAGGCCCACGGTCCCGGCC	0.542000													35	157					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64536656	64536656	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:64536656C>T	uc003dmg.2	-	31	4813	c.4781G>A	c.(4780-4782)CGC>CAC	p.R1594H	ADAMTS9_uc011bfo.1_Missense_Mutation_p.R1566H|ADAMTS9_uc003dmh.1_Missense_Mutation_p.R1423H|ADAMTS9_uc011bfp.1_Missense_Mutation_p.R505H	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1594	TSP type-1 13.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CACGTCACAGCGTGCCCCATG	0.552000													156	64					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123036943	123036943	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:123036943G>A	uc003egh.1	-	11	2278	c.2278C>T	c.(2278-2280)CGA>TGA	p.R760*	ADCY5_uc003egg.1_Nonsense_Mutation_p.R393*|ADCY5_uc003egi.1_Nonsense_Mutation_p.R319*	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	760	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GCACCAAATCGGTCGTCTACC	0.602000													40	11					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126216983	126216983	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:126216983C>T	uc003eiz.1	-	14	1381	c.1349G>A	c.(1348-1350)CGC>CAC	p.R450H	UROC1_uc010hsi.1_Missense_Mutation_p.R510H	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	450			R -> C (in UROD; loss of activity).		histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		GCACACCCAGCGGAAAGGCCC	0.627000													12	360					0	0	1	0	0
ACAD11	84129	broad.mit.edu	37	3	132361582	132361582	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:132361582A>G	uc003eov.3	-	3	694	c.314T>C	c.(313-315)ATA>ACA	p.I105T	ACAD11_uc003eoy.2_Missense_Mutation_p.I105T	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	105						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						GCAGTACAGTATAGGCTTGGG	0.328000													107	31					0	0	1	0	0
ZBTB38	253461	broad.mit.edu	37	3	141163946	141163946	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:141163946G>A	uc003etw.2	+	8	3698	c.2716G>A	c.(2716-2718)GCA>ACA	p.A906T	ZBTB38_uc010hun.2_Missense_Mutation_p.A903T|ZBTB38_uc010huo.2_Missense_Mutation_p.A906T|ZBTB38_uc003ety.2_Missense_Mutation_p.A906T|ZBTB38_uc010hup.2_Missense_Mutation_p.A907T	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	906					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						GTTCGATGACGCAAGTGACCA	0.502000													44	17					0	0	1	0	0
ZBTB38	253461	broad.mit.edu	37	3	141164403	141164403	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:141164403G>A	uc003etw.2	+	8	4155	c.3173G>A	c.(3172-3174)CGC>CAC	p.R1058H	ZBTB38_uc010hun.2_Missense_Mutation_p.R1055H|ZBTB38_uc010huo.2_Missense_Mutation_p.R1058H|ZBTB38_uc003ety.2_Missense_Mutation_p.R1058H|ZBTB38_uc010hup.2_Missense_Mutation_p.R1059H	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	1058	C2H2-type 7.				positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AAACATGAACGCATCCACCTG	0.478000													71	33					0	0	1	0	0
AADACL2	344752	broad.mit.edu	37	3	151461914	151461914	+	Missense_Mutation	SNP	C	T	T	rs145856421		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:151461914C>T	uc003ezc.2	+	3	515	c.395C>T	c.(394-396)ACG>ATG	p.T132M	AADACL2_uc010hvn.2_Translation_Start_Site	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	132						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AATAGATGGACGGCAAACACG	0.358000													72	25					0	0	1	0	0
MCCC1	56922	broad.mit.edu	37	3	182740306	182740306	+	Missense_Mutation	SNP	A	G	G	rs143892743		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:182740306A>G	uc003fle.2	-	16	1905	c.1768T>C	c.(1768-1770)TAC>CAC	p.Y590H	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Missense_Mutation_p.Y473H|MCCC1_uc003flg.2_Missense_Mutation_p.Y481H|MCCC1_uc011bqp.1_Missense_Mutation_p.Y543H	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	590					biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CCCTCGCTGTAAAGATTACCA	0.313000													15	57					0	0	1	0	0
DGKQ	1609	broad.mit.edu	37	4	960969	960969	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:960969G>A	uc003gbw.2	-	9	1242	c.1168C>T	c.(1168-1170)CGG>TGG	p.R390W	DGKQ_uc010ibn.2_Missense_Mutation_p.R390W	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	390					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GGCAGAGCCCGGATGACCCAG	0.711000													3	19					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306942	2306942	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:2306942C>T	uc003gex.1	-	8	1444	c.1125G>A	c.(1123-1125)GCG>GCA	p.A375A	ZFYVE28_uc011bvk.1_Silent_p.A305A|ZFYVE28_uc011bvl.1_Silent_p.A345A|ZFYVE28_uc003gew.1_Silent_p.A261A	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	375					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						GGCTGCCCTCCGCTCCTGGCC	0.667000													48	84					0	0	1	0	0
NOP14	8602	broad.mit.edu	37	4	2943380	2943380	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:2943380C>T	uc003ggj.1	-	15	2200	c.2128G>A	c.(2128-2130)GCC>ACC	p.A710T	C4orf10_uc003ggd.1_RNA|C4orf10_uc003gge.1_Intron|C4orf10_uc003ggg.1_RNA|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Intron|NOP14_uc003ggk.3_Missense_Mutation_p.A710T|NOP14_uc003ggl.2_Missense_Mutation_p.A710T	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	710					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						CCCATGATGGCGTGGAAGGAT	0.662000													19	33					0	0	1	0	0
GRK4	2868	broad.mit.edu	37	4	3037185	3037185	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:3037185G>A	uc003ggn.1	+	13	1797	c.1342G>A	c.(1342-1344)GTG>ATG	p.V448M	GRK4_uc003ggo.1_Missense_Mutation_p.V448M|GRK4_uc003ggp.1_Missense_Mutation_p.V416M|GRK4_uc003ggq.1_Missense_Mutation_p.V416M	NM_182982	NP_892027	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4 isoform	448	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCAGCACCCCGTGTTCAAGGA	0.582000													67	121					0	0	1	0	0
MSX1	4487	broad.mit.edu	37	4	4864532	4864532	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:4864532C>T	uc003gif.2	+	2	809	c.574C>T	c.(574-576)CGC>TGC	p.R192C		NM_002448	NP_002439	P28360	MSX1_HUMAN	msh homeobox 1	186	Homeobox.				apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GCGCAAGTTCCGCCAGAAGCA	0.657000													11	168					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5418644	5418644	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:5418644G>A	uc003gih.1	+	6	609	c.545G>A	c.(544-546)GGC>GAC	p.G182D	STK32B_uc010ida.1_Missense_Mutation_p.G135D	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	182	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						TCCATGGCTGGCACCAAGCCC	0.443000													3	27					0	0	1	0	0
MAN2B2	23324	broad.mit.edu	37	4	6588894	6588894	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:6588894G>A	uc003gjf.1	+	4	599	c.563G>A	c.(562-564)CGG>CAG	p.R188Q	MAN2B2_uc003gje.1_Missense_Mutation_p.R188Q|MAN2B2_uc011bwf.1_Missense_Mutation_p.R188Q	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	188					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						CAGGAGGCCCGGGTGAGTGGT	0.642000													22	42					0	0	1	0	0
HTRA3	94031	broad.mit.edu	37	4	8293224	8293224	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:8293224G>A	uc003gla.2	+	4	1040	c.836G>A	c.(835-837)CGG>CAG	p.R279Q	HTRA3_uc003gkz.2_Missense_Mutation_p.R279Q	NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	279	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						ACTGCCCAGCGGGAGGGCAGG	0.657000													38	37					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9783925	9783925	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:9783925C>T	uc003gmb.3	+	1	668	c.272C>T	c.(271-273)GCG>GTG	p.A91V		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	91	Helical; Name=2; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CTTTTCGTGGCGCTGCTGGTC	0.632000													24	101					0	0	1	0	0
PACRGL	133015	broad.mit.edu	37	4	20715162	20715162	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:20715162C>T	uc010iek.2	+	7	1000	c.609C>T	c.(607-609)AGC>AGT	p.S203S	PACRGL_uc003gpu.2_RNA|PACRGL_uc010iei.1_Silent_p.S251S|PACRGL_uc003gpz.2_Silent_p.S203S|PACRGL_uc011bxm.1_Silent_p.S150S|PACRGL_uc003gqa.2_Silent_p.S105S|PACRGL_uc003gpx.3_RNA|PACRGL_uc003gpv.2_Silent_p.S203S|PACRGL_uc003gpw.2_RNA|PACRGL_uc010iej.1_RNA|PACRGL_uc011bxn.1_Silent_p.S105S|PACRGL_uc003gpy.2_Silent_p.S150S	NM_145048	NP_659485	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like isoform 1	203							binding				0						TGCTTACAAGCGTAAGTACTG	0.373000													34	53					0	0	1	0	0
TMEM156	80008	broad.mit.edu	37	4	38990512	38990512	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:38990512C>T	uc003gto.2	-	4	806	c.698G>A	c.(697-699)CGC>CAC	p.R233H	TMEM156_uc010ifj.2_Missense_Mutation_p.R233H	NM_024943	NP_079219	Q8N614	TM156_HUMAN	transmembrane protein 156	233	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AAGTATTTTGCGGATAGTGAG	0.358000													83	151					0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68447189	68447189	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:68447189C>T	uc003hde.3	+	5	612	c.530C>T	c.(529-531)GCA>GTA	p.A177V	STAP1_uc003hdf.2_Missense_Mutation_p.A177V	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	177	SH2.				cellular membrane fusion|intracellular protein transport	cytoplasm					0						CCTATGCCAGCGTAAGTGCAC	0.393000													56	131					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70079942	70079942	+	Missense_Mutation	SNP	G	A	A	rs148268917		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:70079942G>A	uc003heh.2	-	1	508	c.499C>T	c.(499-501)CGG>TGG	p.R167W	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	167					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						TACACAAACCGTATGTTAAGT	0.418000													51	93					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77662039	77662039	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:77662039C>T	uc011cbx.1	+	5	3666	c.2713C>T	c.(2713-2715)CGG>TGG	p.R905W	SHROOM3_uc011cbz.1_Missense_Mutation_p.R729W|SHROOM3_uc003hkf.1_Missense_Mutation_p.R780W|SHROOM3_uc003hkg.2_Missense_Mutation_p.R683W	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	905					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GCCCGAGTGGCGGGACAGGCC	0.711000													11	19					0	0	1	0	0
BMP2K	55589	broad.mit.edu	37	4	79793824	79793824	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:79793824G>A	uc003hlk.2	+	13	1831	c.1665G>A	c.(1663-1665)CCG>CCA	p.P555P	BMP2K_uc003hlj.2_Silent_p.P555P|BMP2K_uc003hll.2_Silent_p.P19P	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	555	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						AACATCAGCCGTCTCAACAAC	0.443000													36	63					0	0	1	0	0
PRKG2	5593	broad.mit.edu	37	4	82026998	82026998	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:82026998G>A	uc003hmh.2	-	15	2046	c.2032C>T	c.(2032-2034)CGA>TGA	p.R678*	PRKG2_uc011ccf.1_Nonsense_Mutation_p.R258*|PRKG2_uc011ccg.1_Nonsense_Mutation_p.R258*|PRKG2_uc011cch.1_Nonsense_Mutation_p.R649*	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	678	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						TCCTCAGGTCGTCGTGTTATC	0.423000													28	121					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110915913	110915913	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:110915913G>T	uc003hzy.3	+	20	3334	c.2882G>T	c.(2881-2883)AGG>ATG	p.R961M	EGF_uc011cfu.1_Missense_Mutation_p.R919M|EGF_uc011cfv.1_Missense_Mutation_p.R920M|EGF_uc010imk.2_Missense_Mutation_p.R109M	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	961	Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CCTCACCTCAGGGAAGATGAC	0.428000													35	152					1.90571e-15	1.9576e-15	1	1	0
TRPC3	7222	broad.mit.edu	37	4	122835949	122835949	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:122835949C>T	uc003ieg.2	-	4	1401	c.1327G>A	c.(1327-1329)GCA>ACA	p.A443T	TRPC3_uc010inr.2_Intron|TRPC3_uc003ief.2_Missense_Mutation_p.A370T|TRPC3_uc011cgl.1_Missense_Mutation_p.A107T	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	358	Helical; (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						CTGCAAGGTGCGATCCAGTAG	0.483000													29	46					0	0	1	0	0
SLC25A31	83447	broad.mit.edu	37	4	128651877	128651877	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:128651877C>T	uc003ifl.2	+	1	323	c.177C>T	c.(175-177)CCC>CCT	p.P59P		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	59	Solcar 1.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						AGATCAGCCCCGAGGCGCGGT	0.701000													37	50					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151829999	151829999	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:151829999T>G	uc010ipj.2	-	10	1646	c.1172A>C	c.(1171-1173)AAA>ACA	p.K391T	LRBA_uc003ilu.3_Missense_Mutation_p.K391T|LRBA_uc010ipk.1_Missense_Mutation_p.K310T	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	391						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TGCTTTGAATTTAAATGTACC	0.363000													19	64					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151850067	151850067	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:151850067G>A	uc010ipj.2	-	3	841	c.367C>T	c.(367-369)CGG>TGG	p.R123W	LRBA_uc003ilu.3_Missense_Mutation_p.R123W|LRBA_uc010ipk.1_Missense_Mutation_p.R42W	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	123						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TGAAGATTCCGTATGCTTTTC	0.388000													33	144					0	0	1	0	0
SFRP2	6423	broad.mit.edu	37	4	154709690	154709690	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:154709690C>T	uc003inv.1	-	1	539	c.298G>A	c.(298-300)GCC>ACC	p.A100T		NM_003013	NP_003004	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2 precursor	100	FZ.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.093)	Renal(120;0.117)				CAGACGGGGGCGAAGAGCGAG	0.647000													37	220					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155490927	155490927	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:155490927C>T	uc003ioa.3	+	7	1259	c.1220C>T	c.(1219-1221)ACG>ATG	p.T407M	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.T345M|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.T188M	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	407	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TTCTTCAGCACGTATGACAGA	0.423000													46	76					0	0	1	0	0
ACSL1	2180	broad.mit.edu	37	4	185724474	185724474	+	Silent	SNP	C	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:185724474C>A	uc003iww.2	-	2	489	c.195G>T	c.(193-195)GCG>GCT	p.A65A	ACSL1_uc011ckm.1_5'UTR|ACSL1_uc003iwt.1_Silent_p.A65A|ACSL1_uc003iwu.1_Silent_p.A65A|ACSL1_uc011ckn.1_Silent_p.A65A|ACSL1_uc003iwv.1_Silent_p.A65A	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	65	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CTCCACTCACCGCCACTTCCA	0.557000													12	15					7.03913e-09	7.17653e-09	1	1	0
NPR3	4883	broad.mit.edu	37	5	32739001	32739001	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:32739001C>T	uc003jhv.2	+	3	1142	c.924C>T	c.(922-924)CAC>CAT	p.H308H	NPR3_uc010iuo.2_Silent_p.H92H|NPR3_uc011cnz.1_Silent_p.H92H|NPR3_uc003jhu.2_Silent_p.H308H	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	308	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GAGACAAACACGACTTTGAAG	0.428000													49	90					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40854138	40854138	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:40854138G>C	uc003jmg.2	+	3	2779	c.2704G>C	c.(2704-2706)GCA>CCA	p.A902P		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	902					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						CTTTCAACCAGCAGCAGCCAC	0.483000													73	119					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41159281	41159281	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:41159281G>A	uc003jmk.2	-	12	1969	c.1759C>T	c.(1759-1761)CGA>TGA	p.R587*	C6_uc003jml.1_Nonsense_Mutation_p.R587*	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	587	TSP type-1 3.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTGCATTCTCGGGTTCTCGAT	0.493000													58	80					0	0	1	0	0
MIER3	166968	broad.mit.edu	37	5	56231270	56231270	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:56231270C>T	uc003jrd.1	-	7	605	c.580G>A	c.(580-582)GAT>AAT	p.D194N	MIER3_uc003jqz.1_Missense_Mutation_p.D131N|MIER3_uc003jra.1_Missense_Mutation_p.D194N|MIER3_uc003jrb.1_Missense_Mutation_p.D18N|MIER3_uc003jrc.1_Missense_Mutation_p.D199N	NM_152622	NP_689835	Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family	194	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		TCATTACCATCGTACTCTCCA	0.313000													26	121					0	0	1	0	0
CENPK	64105	broad.mit.edu	37	5	64814369	64814369	+	Missense_Mutation	SNP	C	T	T	rs147863579		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:64814369C>T	uc003jts.2	-	11	955	c.743G>A	c.(742-744)CGT>CAT	p.R248H	CENPK_uc003jtt.2_Missense_Mutation_p.R218H|CENPK_uc003jtu.2_Missense_Mutation_p.R248H	NM_022145	NP_071428	Q9BS16	CENPK_HUMAN	SoxLZ/Sox6 leucine zipper binding protein	248					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00466)		AATTCCATTACGCAGCAGCAG	0.353000													35	77					0	0	1	0	0
SLC30A5	64924	broad.mit.edu	37	5	68413208	68413208	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:68413208G>A	uc003jvh.2	+	11	1625	c.1424G>A	c.(1423-1425)CGG>CAG	p.R475Q	SLC30A5_uc003jvj.2_RNA|SLC30A5_uc003jvk.2_Missense_Mutation_p.R204Q|SLC30A5_uc003jvi.2_Missense_Mutation_p.R304Q	NM_022902	NP_075053	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter),	475	Cytoplasmic (Potential).				cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		AAAGCCACTCGGATTTTCTCC	0.413000													65	93					0	0	1	0	0
MARVELD2	153562	broad.mit.edu	37	5	68716104	68716104	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:68716104G>A	uc003jwq.2	+	2	951	c.892G>A	c.(892-894)GTT>ATT	p.V298I	MARVELD2_uc010ixf.2_Missense_Mutation_p.V298I|MARVELD2_uc003jwr.1_Missense_Mutation_p.V298I|MARVELD2_uc003jws.1_Intron	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	298	MARVEL.|Helical; (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		TGGAATTAACGTTGCCTTGTT	0.423000													56	112					0	0	1	0	0
PDE8B	8622	broad.mit.edu	37	5	76649192	76649192	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:76649192G>A	uc003kfa.2	+	10	1173	c.1128G>A	c.(1126-1128)TCG>TCA	p.S376S	PDE8B_uc003kfb.2_Silent_p.S356S|PDE8B_uc003kfc.2_Silent_p.S376S|PDE8B_uc003kfd.2_Silent_p.S329S|PDE8B_uc003kfe.2_Intron	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	376					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		ATTTTGTCTCGCTCAAGAAAC	0.368000													24	43					0	0	1	0	0
ZCCHC9	84240	broad.mit.edu	37	5	80604490	80604490	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:80604490C>T	uc003khj.2	+	3	628	c.495C>T	c.(493-495)CAC>CAT	p.H165H	RNU5E_uc011cto.1_Intron|ZCCHC9_uc003khk.3_Silent_p.H165H|ZCCHC9_uc003khi.2_Silent_p.H165H	NM_001131035	NP_001124507	Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	165	CCHC-type 2.						nucleic acid binding|zinc ion binding			ovary(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		CCACAGAGCACGAAATAACCA	0.448000													38	54					0	0	1	0	0
KIF3A	11127	broad.mit.edu	37	5	132051569	132051569	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:132051569G>A	uc003kxo.2	-	8	1163	c.1009C>T	c.(1009-1011)CGG>TGG	p.R337W	KIF3A_uc003kxn.2_Missense_Mutation_p.R296W|KIF3A_uc011cxf.1_Missense_Mutation_p.R337W|KIF3A_uc003kxp.2_Missense_Mutation_p.R337W	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	337	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGGCATACCGTAATGTACTG	0.328000													7	22					0	0	1	0	0
TMCO6	55374	broad.mit.edu	37	5	140021557	140021557	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:140021557G>A	uc003lgl.2	+	4	518	c.417G>A	c.(415-417)GAG>GAA	p.E139E	TMCO6_uc011czj.1_3'UTR|TMCO6_uc003lgm.2_Silent_p.E139E|TMCO6_uc010jft.2_Intron|TMCO6_uc003lgn.2_Silent_p.E30E|TMCO6_uc003lgo.2_5'Flank	NM_018502	NP_060972	Q96DC7	TMCO6_HUMAN	transmembrane and coiled-coil domains 6	139					protein import into nucleus	cytoplasm|nuclear pore	binding|protein transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCACTCCGAGCAGTCCACTG	0.617000													36	167					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209817	140209817	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:140209817C>T	uc003lho.2	+	1	2168	c.2141C>T	c.(2140-2142)ACG>ATG	p.T714M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.T714M	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	714	Helical; (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGTCCTCACGCTACTGCTG	0.706000													81	128					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769478	140769478	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:140769478G>A	uc003lkc.1	+	1	2027	c.2027G>A	c.(2026-2028)CGC>CAC	p.R676H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.R676H	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	676	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCACTGACCGCCCCGACCCC	0.617000													15	279					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141035270	141035270	+	Missense_Mutation	SNP	C	T	T	rs138515824	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:141035270C>T	uc003llm.2	-	31	4106	c.4028G>A	c.(4027-4029)CGT>CAT	p.R1343H	ARAP3_uc003lll.2_Missense_Mutation_p.R294H|ARAP3_uc011dbe.1_Missense_Mutation_p.R1005H|ARAP3_uc003lln.2_Missense_Mutation_p.R1174H	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1343					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						AAACTTCTGACGGGCAAGGTC	0.597000													41	70					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150029450	150029450	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:150029450G>A	uc003lsn.2	+	3	2719	c.2345G>A	c.(2344-2346)CGG>CAG	p.R782Q	SYNPO_uc003lso.3_Missense_Mutation_p.R538Q|SYNPO_uc003lsp.2_Missense_Mutation_p.R538Q	NM_001109974	NP_001103444	Q8N3V7	SYNPO_HUMAN	synaptopodin isoform B	782	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			large_intestine(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCCAGCCCGGACCCCGCCT	0.687000													55	211					0	0	1	0	0
SLC36A1	206358	broad.mit.edu	37	5	150856223	150856223	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:150856223G>A	uc003luc.2	+	9	1112	c.895G>A	c.(895-897)GTC>ATC	p.V299I	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Missense_Mutation_p.V299I|SLC36A1_uc010jhw.1_Missense_Mutation_p.V299I	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	299	Helical; Name=7; (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	CATGGTCATCGTCACCATCCT	0.517000													54	82					0	0	1	0	0
ODZ2	57451	broad.mit.edu	37	5	167689238	167689238	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:167689238C>T	uc010jjd.2	+	29	7721	c.7721C>T	c.(7720-7722)ACG>ATG	p.T2574M	ODZ2_uc003lzr.3_Missense_Mutation_p.T2344M|ODZ2_uc003lzt.3_Missense_Mutation_p.T1947M|ODZ2_uc010jje.2_Missense_Mutation_p.T1838M	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CGGGTGACCACGGGCGTGTCC	0.572000													4	11					0	0	1	0	0
GPRIN1	114787	broad.mit.edu	37	5	176025905	176025905	+	Nonsense_Mutation	SNP	C	A	A	rs147380779	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:176025905C>A	uc003meo.1	-	2	1106	c.931G>T	c.(931-933)GGA>TGA	p.G311*		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	311						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTGTCTTTCCTGTGGACGCA	0.572000													64	115					6.75472e-32	6.9703e-32	1	1	0
SNCB	6620	broad.mit.edu	37	5	176056600	176056600	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:176056600G>A	uc003mep.2	-	3	499	c.56C>T	c.(55-57)GCG>GTG	p.A19V	SNCB_uc003meq.2_Missense_Mutation_p.A19V|SNCB_uc010jke.1_Missense_Mutation_p.A19V|hsa-mir-4281|MI0015885_5'Flank|EIF4E1B_uc010jkf.1_5'Flank	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	19							calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGTTTTCTCCGCGGCTGCCAC	0.677000													11	52					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178566910	178566910	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:178566910G>A	uc003mjw.2	-	11	1756	c.1756C>T	c.(1756-1758)CGC>TGC	p.R586C		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	586	TSP type-1 1.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TCACACTGGCGGGTCCTGAAC	0.642000													107	116					0	0	1	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179043155	179043155	+	Silent	SNP	G	A	A	rs115293737	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:179043155G>A	uc003mkf.3	-	12	1378	c.1272C>T	c.(1270-1272)TAC>TAT	p.Y424Y	HNRNPH1_uc011dgn.1_Silent_p.Y134Y|HNRNPH1_uc003mkg.3_Silent_p.Y332Y|HNRNPH1_uc003mke.3_Silent_p.Y424Y|HNRNPH1_uc003mkh.3_Silent_p.Y424Y	NM_005520	NP_005511	P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1	424	1-2.|2 X 16 AA Gly-rich approximate repeats.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding				0						TCTGGCCACCGTAGCCGCCTC	0.473000													38	229					0	0	1	0	0
MAPK9	5601	broad.mit.edu	37	5	179676062	179676062	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:179676062G>A	uc003mls.3	-	6	798	c.527C>T	c.(526-528)GCG>GTG	p.A176V	MAPK9_uc003mlt.3_Missense_Mutation_p.A176V|MAPK9_uc010jlc.2_Missense_Mutation_p.A176V|MAPK9_uc003mlv.3_Missense_Mutation_p.A176V|MAPK9_uc011dgx.1_Missense_Mutation_p.A176V	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	176	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTAGTGCACGCTGTCCGGGC	0.498000													128	161					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180046723	180046723	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:180046723G>A	uc003mma.3	-	18	2668	c.2589C>T	c.(2587-2589)TCC>TCT	p.S863S	FLT4_uc003mlz.3_Silent_p.S863S|FLT4_uc003mmb.1_Silent_p.S396S	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	863	Cytoplasmic (Potential).|Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGCCGAAAGCGGAGGCTTCCA	0.657000									Congenital_Hereditary_Lymphedema				84	160					0	0	1	0	0
TMEM14C	51522	broad.mit.edu	37	6	10725225	10725225	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:10725225G>A	uc003mzh.2	+	3	233	c.52G>A	c.(52-54)GCA>ACA	p.A18T	TMEM14C_uc010joq.1_Missense_Mutation_p.A18T|TMEM14C_uc003mzi.2_Missense_Mutation_p.A18T	NM_016462	NP_057546	Q9P0S9	TM14C_HUMAN	transmembrane protein 14C	18	Helical; (Potential).				heme biosynthetic process	integral to membrane|mitochondrial membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.135)	Epithelial(50;0.246)			CTTTGGCTACGCAGCACTGGT	0.448000													87	278					0	0	1	0	0
HCG4	54435	broad.mit.edu	37	6	29759996	29759996	+	RNA	SNP	T	C	C	rs1610645		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:29759996T>C	uc003nns.2	-	1		c.855A>G			uc010jrm.1_Intron|uc003nnt.2_Missense_Mutation_p.F71S|uc011dma.1_5'Flank	NR_002139				Homo sapiens clone HCG IV.9 unknown mRNA.												0						CTCCGATTCTTCCCAGTCGCC	0.622000													2	11					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30552327	30552327	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:30552327C>T	uc003nql.2	+	14	1470	c.1375C>T	c.(1375-1377)CGT>TGT	p.R459C	ABCF1_uc003nqk.2_Missense_Mutation_p.R460C|ABCF1_uc003nqm.2_Missense_Mutation_p.R421C|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	459	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						CTGGCGCATGCGTGTCTCCCT	0.612000													38	34					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36978766	36978766	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:36978766C>T	uc010jwp.1	+	3	489	c.318C>T	c.(316-318)ATC>ATT	p.I106I	FGD2_uc011dtu.1_Silent_p.I106I|FGD2_uc003ong.2_5'UTR|FGD2_uc011dtv.1_Intron|FGD2_uc003oni.1_5'Flank	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	106	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						AGAAGAAGATCGTCCAGGAGC	0.612000													12	72					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43044258	43044258	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:43044258C>A	uc003oub.1	+	1	230	c.32C>A	c.(31-33)CCC>CAC	p.P11H	PTK7_uc003ouc.1_Missense_Mutation_p.P11H|PTK7_uc003oud.1_Missense_Mutation_p.P11H|PTK7_uc003oue.1_Missense_Mutation_p.P11H|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_5'Flank|PTK7_uc003oua.2_Missense_Mutation_p.P11H	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	11					actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CCGGCCAGACCCCGCCGGTTG	0.736000													19	9					1.15919e-05	1.17301e-05	1	1	0
TDRD6	221400	broad.mit.edu	37	6	46656282	46656282	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:46656282C>T	uc003oyj.2	+	1	417	c.417C>T	c.(415-417)TGC>TGT	p.C139C	TDRD6_uc010jze.2_Silent_p.C133C	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	139					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CGGCAGGCTGCGGCGCGGGCT	0.711000													4	19					0	0	1	0	0
PEX3	8504	broad.mit.edu	37	6	143793364	143793364	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:143793364G>A	uc003qjl.2	+	8	908	c.646G>A	c.(646-648)GTT>ATT	p.V216I	PEX3_uc011edx.1_Missense_Mutation_p.V216I	NM_003630	NP_003621	P56589	PEX3_HUMAN	peroxisomal biogenesis factor 3	216	Cytoplasmic (Potential).				protein import into peroxisome membrane|transmembrane transport	integral to peroxisomal membrane	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.73e-06)|GBM - Glioblastoma multiforme(68;0.0117)		CAGAAATCTCGTTGAGCAGCA	0.348000													38	18					0	0	1	0	0
WTAP	9589	broad.mit.edu	37	6	160176453	160176453	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:160176453C>T	uc003qsl.2	+	8	1223	c.1001C>T	c.(1000-1002)GCG>GTG	p.A334V	WTAP_uc003qso.2_Missense_Mutation_p.A215V	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	334					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		CAACTCAGTGCGGGGTATGAA	0.483000													33	64					0	0	1	0	0
FRMD1	79981	broad.mit.edu	37	6	168463623	168463623	+	Missense_Mutation	SNP	C	T	T	rs115999698	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:168463623C>T	uc003qwo.3	-	7	886	c.821G>A	c.(820-822)CGT>CAT	p.R274H	FRMD1_uc003qwm.3_Missense_Mutation_p.R45H|FRMD1_uc011egs.1_Missense_Mutation_p.R45H|FRMD1_uc011egt.1_Missense_Mutation_p.R186H|FRMD1_uc003qwn.3_Missense_Mutation_p.R206H	NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	274	FERM.					cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CACGGTGGGACGACCTTCCTT	0.622000													29	58					0	0	1	0	0
FAM120B	84498	broad.mit.edu	37	6	170626760	170626760	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:170626760G>T	uc003qxp.2	+	2	390	c.282G>T	c.(280-282)GAG>GAT	p.E94D	FAM120B_uc003qxo.1_Missense_Mutation_p.E94D|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	94					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		GCATGGTGGAGCAGGATAAGA	0.443000													7	93					0.0293803	0.0294671	1	1	0
GPER	2852	broad.mit.edu	37	7	1132151	1132151	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:1132151G>A	uc010ksd.1	+	2	1176	c.787G>A	c.(787-789)GCG>ACG	p.A263T	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Missense_Mutation_p.A263T|GPER_uc003ska.1_Missense_Mutation_p.A263T|GPER_uc003skb.2_Missense_Mutation_p.A263T	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	263	Helical; Name=6; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CATGATCCTCGCGGTGGTGCT	0.687000													49	94					0	0	1	0	0
KIAA0415	9907	broad.mit.edu	37	7	4824642	4824642	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:4824642C>T	uc003sne.2	+	7	977	c.894C>T	c.(892-894)TTC>TTT	p.F298F	KIAA0415_uc010ksp.2_RNA	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	298					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		AGGTGGCCTTCGAGTACTGCC	0.682000													44	63					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5540761	5540761	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:5540761G>A	uc003soo.2	-	3	1233	c.1139C>T	c.(1138-1140)GCG>GTG	p.A380V	FBXL18_uc003son.3_Missense_Mutation_p.A380V	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	380	LRR 6.									central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GCAGCAGGACGCCACCAGAGT	0.687000													20	105					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27135248	27135248	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:27135248C>T	uc003sye.2	-	1	378	c.284G>A	c.(283-285)TGT>TAT	p.C95Y	HOXA1_uc003syd.2_Missense_Mutation_p.C95Y|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	95						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						GCTTGGACCACAACTTGAGTG	0.488000											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	29	149					0	0	1	0	0
GGCT	79017	broad.mit.edu	37	7	30538452	30538452	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:30538452G>A	uc003tba.2	-	3	517	c.390C>T	c.(388-390)TAC>TAT	p.Y130Y	GGCT_uc003tbb.2_Intron|GGCT_uc003tbc.2_RNA|GGCT_uc003taz.2_Silent_p.Y69Y	NM_024051	NP_076956	O75223	GGCT_HUMAN	gamma-glutamyl cyclotransferase	130					release of cytochrome c from mitochondria	cytosol	acyltransferase activity|gamma-glutamylcyclotransferase activity|protein homodimerization activity				0						GAGCACTTTCGTAATTTGTCA	0.338000													63	94					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43484733	43484733	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:43484733C>T	uc003tid.1	+	11	2567	c.1962C>T	c.(1960-1962)ACC>ACT	p.T654T	HECW1_uc011kbi.1_Silent_p.T654T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	654					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						ACCCCAGCACCGGGAGCGAGA	0.716000													33	47					0	0	1	0	0
C7orf42	55069	broad.mit.edu	37	7	66415965	66415965	+	Missense_Mutation	SNP	C	T	T	rs143613938	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:66415965C>T	uc003tvk.2	+	5	887	c.623C>T	c.(622-624)ACG>ATG	p.T208M	C7orf42_uc010lah.2_Intron|C7orf42_uc003tvl.2_Missense_Mutation_p.T208M	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	208						integral to membrane				ovary(1)	1						GTTCCTGACACGTACAGCAAC	0.522000													60	277					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72281140	72281140	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:72281140G>A	uc011kej.1	-	4	508	c.349C>T	c.(349-351)CGA>TGA	p.R117*	TYW1B_uc011keh.1_Intron|TYW1B_uc011kek.1_Intron	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	117	Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						TTGCCAAATCGAAAATCAATG	0.448000													100	132					0	0	1	0	0
FKBP6	8468	broad.mit.edu	37	7	72754699	72754699	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:72754699C>T	uc003tya.2	+	6	780	c.648C>T	c.(646-648)GCC>GCT	p.A216A	FKBP6_uc003twz.2_Silent_p.A186A|FKBP6_uc011kew.1_Silent_p.A211A|FKBP6_uc010lbe.1_RNA	NM_003602	NP_003593	O75344	FKBP6_HUMAN	FK506 binding protein 6 isoform a	216					protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				TGGTGGAGGCCGCCAAGCTTC	0.572000													24	112					0	0	1	0	0
MLXIPL	51085	broad.mit.edu	37	7	73013863	73013863	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:73013863C>T	uc003tyn.1	-	8	1112	c.1064G>A	c.(1063-1065)CGT>CAT	p.R355H	MLXIPL_uc003tyj.1_5'Flank|MLXIPL_uc003tyk.1_Missense_Mutation_p.R355H|MLXIPL_uc003tyl.1_Missense_Mutation_p.R355H|MLXIPL_uc003tym.1_Missense_Mutation_p.R355H|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.R262H|MLXIPL_uc003tyq.1_Missense_Mutation_p.R97H	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	355					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				CACCTGCAGACGGCTGTGTCC	0.587000													47	90					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584436	82584436	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:82584436G>A	uc003uhx.2	-	5	6122	c.5833C>T	c.(5833-5835)CCT>TCT	p.P1945S	PCLO_uc003uhv.2_Missense_Mutation_p.P1945S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1876					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CCATACAAAGGCTCTTTTTCA	0.373000													13	67					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83823817	83823817	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:83823817A>G	uc003uhz.2	-	1	401	c.86T>C	c.(85-87)GTG>GCG	p.V29A		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	29					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						CAGCCTTGGCACATTGTTCTT	0.418000													29	210					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91737807	91737807	+	Splice_Site	SNP	G	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:91737807G>T	uc003ulg.2	+	49	11772	c.11547_splice	c.e49-1	p.R3849_splice	AKAP9_uc003ulf.2_Splice_Site_p.R3841_splice|AKAP9_uc003uli.2_Splice_Site_p.R3472_splice|AKAP9_uc003ulj.2_Splice_Site_p.R1619_splice|AKAP9_uc003ull.2_Splice_Site_p.R745_splice	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2						G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TAATCCTTTAGGTACCCAGGC	0.423000			T	BRAF	papillary thyroid								15	98					1.67942e-08	1.70963e-08	1	1	0
FBXL13	222235	broad.mit.edu	37	7	102669158	102669158	+	Missense_Mutation	SNP	C	T	T	rs147832645	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:102669158C>T	uc003vaq.2	-	4	533	c.106G>A	c.(106-108)GTC>ATC	p.V36I	FBXL13_uc010lir.1_Missense_Mutation_p.V36I|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.V36I|FBXL13_uc003vav.2_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	36											0						TCAGCCAGGACGACATTTTCA	0.343000													29	41					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115590971	115590971	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:115590971G>A	uc003vhj.1	-	6	656	c.472C>T	c.(472-474)CGA>TGA	p.R158*	TFEC_uc003vhk.1_Nonsense_Mutation_p.R129*|TFEC_uc003vhl.3_Nonsense_Mutation_p.R129*|TFEC_uc011kmw.1_Nonsense_Mutation_p.R248*	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	158	Helix-loop-helix motif.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			TCCTTGATTCGGTAATTAATA	0.299000													15	43					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128483620	128483620	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:128483620G>A	uc003vnz.3	+	18	3009	c.2800G>A	c.(2800-2802)GCT>ACT	p.A934T	FLNC_uc003voa.3_Missense_Mutation_p.A934T	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	934	Filamin 7.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CAAGTACACCGCTGTCCAGCA	0.612000													43	79					0	0	1	0	0
C7orf45	136263	broad.mit.edu	37	7	129856218	129856218	+	Nonsense_Mutation	SNP	C	T	T	rs146470357		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:129856218C>T	uc003vpp.2	+	3	690	c.643C>T	c.(643-645)CGA>TGA	p.R215*		NM_145268	NP_660311	Q8WWF3	CG045_HUMAN	hypothetical protein LOC136263	215						integral to membrane					0	Melanoma(18;0.0435)					GCACCATTCCCGACAGAAGCC	0.438000													119	192					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141724872	141724872	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:141724872C>T	uc003vwy.2	+	8	959	c.905C>T	c.(904-906)GCG>GTG	p.A302V		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	302	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTGTATGGTGCGCAGACATTC	0.398000													19	44					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144096159	144096159	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:144096159G>A	uc011kue.1	-	8	1353	c.1353C>T	c.(1351-1353)GCC>GCT	p.A451A		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	451	Pro-rich.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					AAGGAAGATCGGCCCTTCGCA	0.632000													11	25					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147600796	147600796	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:147600796C>T	uc003weu.1	+	14	2754	c.2238C>T	c.(2236-2238)GAC>GAT	p.D746D		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	746	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTAACTGCGACGCGGACTACA	0.537000										HNSCC(39;0.1)			15	26					0	0	1	0	0
Unknown	0	broad.mit.edu	37	7	148963729	148963729	+	RNA	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:148963729C>T	uc003wfr.3	+	2		c.491C>T								Homo sapiens cDNA FLJ36716 fis, clone UTERU2010651.																		CGGGCTGCTGCAGAGGCGGCT	0.647000													9	232					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154862918	154862918	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:154862918C>T	uc003wlu.1	+	1	373	c.309C>T	c.(307-309)TCC>TCT	p.S103S	uc011kvt.1_Silent_p.P32P|uc003wlt.2_Silent_p.P32P	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	103	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		ACGAGCTGTCCGGGCGCCGCT	0.677000													41	58					0	0	1	0	0
RBM33	155435	broad.mit.edu	37	7	155457901	155457901	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:155457901G>A	uc010lqk.1	+	2	444	c.76G>A	c.(76-78)GCG>ACG	p.A26T	RBM33_uc003wme.2_Missense_Mutation_p.A26T	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	26							nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		TAAGCCTGGCGCGGAACGGTC	0.453000													41	59					0	0	1	0	0
PRSS55	203074	broad.mit.edu	37	8	10383214	10383214	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:10383214G>A	uc003wta.2	+	1	134	c.119G>A	c.(118-120)CGC>CAC	p.R40H	uc010lru.2_Intron	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	40	Extracellular (Potential).				proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						GGAGCCCACCGCCCTCAGCCC	0.662000													13	23					0	0	1	0	0
FAM167A	83648	broad.mit.edu	37	8	11301958	11301958	+	Translation_Start_Site	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:11301958C>T	uc010lry.1	-	2	583	c.-37G>A	c.(-39--35)CCGTG>CCATG		FAM167A_uc003wtw.2_Translation_Start_Site	NM_053279	NP_444509	Q96KS9	F167A_HUMAN	hypothetical protein LOC83648												0						TGCGAGGGCACGGGGGGCGCA	0.682000													24	84					0	0	1	0	0
EPB49	2039	broad.mit.edu	37	8	21926949	21926949	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:21926949C>T	uc011kyt.1	+	6	543	c.314C>T	c.(313-315)TCG>TTG	p.S105L	EPB49_uc010ltl.2_Missense_Mutation_p.S105L|EPB49_uc011kys.1_Missense_Mutation_p.S65L|EPB49_uc010ltn.2_Missense_Mutation_p.S80L|EPB49_uc011kyu.1_Missense_Mutation_p.S105L|EPB49_uc011kyv.1_Missense_Mutation_p.S105L|EPB49_uc010ltq.2_Missense_Mutation_p.S105L	NM_001114136	NP_001107608	Q08495	DEMA_HUMAN	erythrocyte membrane protein band 4.9 isoform 1	105					actin filament bundle assembly|actin filament capping	actin cytoskeleton|nucleus	actin binding			central_nervous_system(1)	1				Colorectal(74;9.05e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0631)		GACAGCCGGTCGCCTGGAATC	0.657000													17	38					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22037987	22037987	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:22037987C>T	uc003xbg.2	+	8	1312	c.1068C>T	c.(1066-1068)CCC>CCT	p.P356P	BMP1_uc003xba.2_Silent_p.P356P|BMP1_uc003xbb.2_Silent_p.P356P|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_Silent_p.P105P|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_Silent_p.P105P|BMP1_uc011kzc.1_Silent_p.P105P|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	356	CUB 1.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		CTGTCACACCCGGGGAGAAGG	0.612000													51	83					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	28989840	28989840	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:28989840C>T	uc003xhh.3	-	23	2986	c.2927G>A	c.(2926-2928)CGT>CAT	p.R976H	uc003xhi.1_Intron	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	976					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CCGAAGACTACGTGTCTTTGC	0.323000													30	70					0	0	1	0	0
HTRA4	203100	broad.mit.edu	37	8	38840023	38840023	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:38840023C>T	uc003xmj.2	+	7	1236	c.1121C>T	c.(1120-1122)GCG>GTG	p.A374V		NM_153692	NP_710159	P83105	HTRA4_HUMAN	HtrA serine peptidase 4 precursor	374					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			CCAGGAAAGGCGTTTTCAAAT	0.428000													16	46					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41554024	41554024	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:41554024C>T	uc003xok.2	-	26	2901	c.2817G>A	c.(2815-2817)CCG>CCA	p.P939P	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Silent_p.P255P|ANK1_uc003xoi.2_Silent_p.P939P|ANK1_uc003xoj.2_Silent_p.P939P|ANK1_uc003xol.2_Silent_p.P939P|ANK1_uc003xom.2_Silent_p.P980P	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	939	ZU5.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACGTCCGTGGCGGGATCACCA	0.677000													25	45					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41577305	41577305	+	Silent	SNP	G	A	A	rs61758867	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:41577305G>A	uc003xok.2	-	10	1065	c.981C>T	c.(979-981)TAC>TAT	p.Y327Y	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Silent_p.Y327Y|ANK1_uc003xoj.2_Silent_p.Y327Y|ANK1_uc003xol.2_Silent_p.Y327Y|ANK1_uc003xom.2_Silent_p.Y360Y	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	327	ANK 9.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCTCTGCGTCGTATTGCAACA	0.567000													51	103					0	0	1	0	0
PI15	51050	broad.mit.edu	37	8	75737579	75737579	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:75737579C>T	uc003yal.2	+	2	274	c.95C>T	c.(94-96)CCG>CTG	p.P32L	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.P32L	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	32						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			GACTCATCCCCGCCAACCAAT	0.478000													57	93					0	0	1	0	0
CPNE3	8895	broad.mit.edu	37	8	87559941	87559941	+	Silent	SNP	T	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:87559941T>C	uc003ydv.2	+	11	984	c.822T>C	c.(820-822)ATT>ATC	p.I274I	CPNE3_uc003ydw.1_5'UTR	NM_003909	NP_003900	O75131	CPNE3_HUMAN	copine III	274					lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			ovary(1)|skin(1)	2						ATTTTTAGATTACAGTAGAAT	0.308000													7	10					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	92972726	92972726	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:92972726C>T	uc003yfd.2	-	11	1643	c.1559G>A	c.(1558-1560)CGT>CAT	p.R520H	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R493H|RUNX1T1_uc003yfe.1_Missense_Mutation_p.R483H|RUNX1T1_uc010mao.2_Missense_Mutation_p.R493H|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R531H|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Missense_Mutation_p.R145H|RUNX1T1_uc003yfb.1_Missense_Mutation_p.R483H	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	520	MYND-type.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R483H(2)|p.R520H(2)		lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			ACTCGCTTTACGGCCACAATT	0.458000													23	39					0	0	1	0	0
EIF2C2	27161	broad.mit.edu	37	8	141595388	141595388	+	Silent	SNP	C	T	T	rs141930048	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:141595388C>T	uc003yvn.2	-	2	85	c.45G>A	c.(43-45)CCG>CCA	p.P15P	EIF2C2_uc010men.2_Intron|EIF2C2_uc010meo.2_Silent_p.P15P	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	15					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			GGATGGGGGGCGGCGGCGCAG	0.592000													30	62					0	0	1	0	0
GPR20	2843	broad.mit.edu	37	8	142367203	142367203	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:142367203G>A	uc003ywf.2	-	2	910	c.821C>T	c.(820-822)ACG>ATG	p.T274M		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	274	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CACGAGGCTCGTGTGGTGTGG	0.637000													11	45					0	0	1	0	0
ARC	23237	broad.mit.edu	37	8	143694472	143694472	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:143694472G>A	uc003ywn.1	-	1	1362	c.1161C>T	c.(1159-1161)TCC>TCT	p.S387S		NM_015193	NP_056008	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated	387					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)	1	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				CACTGGCCACGGACTCGCTGT	0.701000													11	11					0	0	1	0	0
ZFP41	286128	broad.mit.edu	37	8	144332526	144332526	+	Silent	SNP	C	T	T	rs149671213		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:144332526C>T	uc003yxw.2	+	2	871	c.513C>T	c.(511-513)TAC>TAT	p.Y171Y	ZFP41_uc003yxv.2_RNA	NM_173832	NP_776193	Q8N8Y5	ZFP41_HUMAN	zinc finger protein 41 homolog	171	C2H2-type 4.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			AGAAGCCCTACGAATGCACGC	0.592000													40	114					0	0	1	0	0
ZFP41	286128	broad.mit.edu	37	8	144332534	144332534	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:144332534C>T	uc003yxw.2	+	2	879	c.521C>T	c.(520-522)ACG>ATG	p.T174M	ZFP41_uc003yxv.2_RNA	NM_173832	NP_776193	Q8N8Y5	ZFP41_HUMAN	zinc finger protein 41 homolog	174	C2H2-type 4.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			TACGAATGCACGCACTGTGGG	0.592000													42	112					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144991396	144991396	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:144991396C>T	uc003zaf.1	-	32	13174	c.13004G>A	c.(13003-13005)CGC>CAC	p.R4335H	PLEC_uc003zab.1_Missense_Mutation_p.R4198H|PLEC_uc003zac.1_Missense_Mutation_p.R4202H|PLEC_uc003zad.2_Missense_Mutation_p.R4198H|PLEC_uc003zae.1_Missense_Mutation_p.R4166H|PLEC_uc003zag.1_Missense_Mutation_p.R4176H|PLEC_uc003zah.2_Missense_Mutation_p.R4184H|PLEC_uc003zaj.2_Missense_Mutation_p.R4225H	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4335	Globular 2.|Plectin 28.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCGCCCGGAGCGGCGGTCGAT	0.637000													21	47					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144999421	144999421	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:144999421C>T	uc003zaf.1	-	31	5257	c.5087G>A	c.(5086-5088)CGA>CAA	p.R1696Q	PLEC_uc003zab.1_Missense_Mutation_p.R1559Q|PLEC_uc003zac.1_Missense_Mutation_p.R1563Q|PLEC_uc003zad.2_Missense_Mutation_p.R1559Q|PLEC_uc003zae.1_Missense_Mutation_p.R1527Q|PLEC_uc003zag.1_Missense_Mutation_p.R1537Q|PLEC_uc003zah.2_Missense_Mutation_p.R1545Q|PLEC_uc003zaj.2_Missense_Mutation_p.R1586Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1696	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTGCCGCGCTCGCTCCACCTC	0.741000													4	15					0	0	1	0	0
PARP10	84875	broad.mit.edu	37	8	145058234	145058234	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:145058234G>A	uc003zal.3	-	7	1827	c.1719C>T	c.(1717-1719)AAC>AAT	p.N573N	PARP10_uc003zak.3_Silent_p.N279N|PARP10_uc011lku.1_Silent_p.N585N|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Silent_p.N573N	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	573						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGTGTGGGCGTTGCCAGGGA	0.662000													13	37					0	0	1	0	0
KDM4C	23081	broad.mit.edu	37	9	6990511	6990511	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:6990511G>A	uc003zkh.2	+	12	2353	c.1773G>A	c.(1771-1773)GCG>GCA	p.A591A	KDM4C_uc010mhu.2_Silent_p.A613A|KDM4C_uc011lmi.1_Silent_p.A591A|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Silent_p.A591A|KDM4C_uc011lmk.1_Intron|KDM4C_uc011lml.1_Silent_p.A278A	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	591					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						AGCAGCAGGCGCCAAGTGATG	0.408000													5	31					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8636794	8636794	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:8636794C>T	uc003zkk.2	-	12	826	c.115G>A	c.(115-117)GGA>AGA	p.G39R	PTPRD_uc003zkp.2_Missense_Mutation_p.G39R|PTPRD_uc003zkq.2_Missense_Mutation_p.G39R|PTPRD_uc003zkr.2_Missense_Mutation_p.G39R|PTPRD_uc003zks.2_Missense_Mutation_p.G39R|PTPRD_uc003zkl.2_Missense_Mutation_p.G39R|PTPRD_uc003zkm.2_Missense_Mutation_p.G39R|PTPRD_uc003zkn.2_Missense_Mutation_p.G39R|PTPRD_uc003zko.2_Missense_Mutation_p.G39R|PTPRD_uc003zkt.1_Missense_Mutation_p.G39R	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	39	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAGGCAACTCCGCCAGAGACC	0.413000										TSP Lung(15;0.13)			50	96					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774426	40774426	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:40774426G>A	uc004abs.2	-	5	1001	c.849C>T	c.(847-849)ACC>ACT	p.T283T	ZNF658_uc010mmm.1_Silent_p.T283T|ZNF658_uc010mmn.1_Silent_p.T283T	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ATTCAACAGCGGTGGTTTTGT	0.383000													8	185					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77376996	77376996	+	Missense_Mutation	SNP	G	A	A	rs141526694	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:77376996G>A	uc004ajl.1	-	26	4829	c.4591C>T	c.(4591-4593)CGC>TGC	p.R1531C	TRPM6_uc004ajk.1_Missense_Mutation_p.R1526C|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.R487C	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1531	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CTGTATCTGCGGAGAGGATTG	0.423000													41	70					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77390827	77390827	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:77390827G>A	uc004ajl.1	-	24	3613	c.3375C>T	c.(3373-3375)CAC>CAT	p.H1125H	TRPM6_uc004ajk.1_Silent_p.H1120H|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Silent_p.H81H	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1125	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CTTCTTGGTCGTGAGGAGCTC	0.537000													68	108					0	0	1	0	0
Unknown	0	broad.mit.edu	37	9	78943040	78943040	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:78943040C>T	uc004akc.1	+	5	850	c.630C>T	c.(628-630)TCC>TCT	p.S210S						Homo sapiens cDNA FLJ16215 fis, clone CTONG2025610, moderately similar to PC6B.																		GCTCACCCTCCGAGTACTGGG	0.592000													13	372					0	0	1	0	0
FLJ46321	389763	broad.mit.edu	37	9	84607751	84607751	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:84607751C>T	uc004amn.2	+	4	2413	c.2366C>T	c.(2365-2367)CCG>CTG	p.P789L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	789						integral to membrane					0						TTGCATGGTCCGGAGACTTCT	0.478000													47	88					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86465050	86465050	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:86465050C>T	uc004ana.2	-	16	3664	c.3520G>A	c.(3520-3522)GAA>AAA	p.E1174K	KIF27_uc010mpw.2_Missense_Mutation_p.E1108K|KIF27_uc010mpx.2_Missense_Mutation_p.E1077K	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	1174					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						ATCTTTTGTTCGTGTTCCTTT	0.423000													38	161					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88967854	88967854	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:88967854G>A	uc004aoq.2	-	2	476	c.261C>T	c.(259-261)CCC>CCT	p.P87P	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Silent_p.P87P|ZCCHC6_uc004aou.2_Silent_p.P87P|ZCCHC6_uc004aov.2_Silent_p.P87P|ZCCHC6_uc004aow.2_Silent_p.P87P|ZCCHC6_uc010mqf.1_Silent_p.P87P	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	87					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TCATCCAAGCGGGTTGACTGT	0.433000													94	184					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	91993634	91993634	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:91993634G>A	uc004aqo.1	-	18	3146	c.2574C>T	c.(2572-2574)GAC>GAT	p.D858D	SEMA4D_uc011ltm.1_Intron|SEMA4D_uc011ltn.1_Intron|SEMA4D_uc011lto.1_Intron|SEMA4D_uc004aqp.1_Silent_p.D856D	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	858	Cytoplasmic (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						CTCCATCTGCGTCTGAGTCAG	0.582000													30	42					0	0	1	0	0
FGD3	89846	broad.mit.edu	37	9	95738979	95738979	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:95738979C>T	uc004asw.2	+	3	1069	c.441C>T	c.(439-441)GCC>GCT	p.A147A	FGD3_uc004asx.2_Silent_p.A147A|FGD3_uc004asz.2_Silent_p.A147A	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	147					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						ACAAGGATGCCGGCCTGGCCC	0.637000													13	34					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112166752	112166752	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:112166752G>A	uc004bed.2	-	19	2041	c.1929C>T	c.(1927-1929)AGC>AGT	p.S643S	PTPN3_uc004beb.2_Silent_p.S512S|PTPN3_uc004bec.2_Silent_p.S467S|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.S598S|PTPN3_uc011lwh.1_Silent_p.S489S|PTPN3_uc011lwd.1_Silent_p.S111S|PTPN3_uc011lwe.1_Silent_p.S356S|PTPN3_uc011lwf.1_Silent_p.S311S	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	643					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						GCACCGTCCCGCTTTCGAGGC	0.502000													48	73					0	0	1	0	0
C9orf152	401546	broad.mit.edu	37	9	112963591	112963591	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:112963591C>T	uc011lwk.1	-	2	911	c.357G>A	c.(355-357)ACG>ACA	p.T119T		NM_001012993	NP_001013011	Q5JTZ5	CI152_HUMAN	hypothetical protein LOC401546	119											0						TCTCCAGGTGCGTGTGCCATG	0.587000													22	142					0	0	1	0	0
ZNF618	114991	broad.mit.edu	37	9	116811427	116811427	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:116811427C>T	uc004bid.2	+	15	1944	c.1845C>T	c.(1843-1845)TAC>TAT	p.Y615Y	ZNF618_uc004bic.2_Silent_p.Y522Y|ZNF618_uc011lxi.1_Silent_p.Y582Y|ZNF618_uc011lxj.1_Silent_p.Y583Y|ZNF618_uc010mvb.2_Silent_p.Y205Y	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	615					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGACAGTGTACGTGACGGATT	0.612000													27	195					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119097282	119097282	+	Silent	SNP	C	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:119097282C>A	uc004bjn.2	+	13	3921	c.3540C>A	c.(3538-3540)TCC>TCA	p.S1180S	PAPPA_uc011lxp.1_Silent_p.S875S|PAPPA_uc011lxq.1_Silent_p.S555S	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1180					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CCCTCCGTTCCTTCGACAACT	0.642000													62	119					4.46356e-37	4.61302e-37	1	1	0
TLR4	7099	broad.mit.edu	37	9	120476694	120476694	+	Missense_Mutation	SNP	G	A	A	rs5030723	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:120476694G>A	uc004bjz.2	+	3	2579	c.2288G>A	c.(2287-2289)CGT>CAT	p.R763H	TLR4_uc004bka.2_Missense_Mutation_p.R723H|TLR4_uc004bkb.2_Missense_Mutation_p.R563H	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	763	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CTGAGCAGTCGTGCTGGTATC	0.527000													5	94					0	0	1	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123215886	123215886	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:123215886C>T	uc004bkf.2	-	21	2822	c.2641G>A	c.(2641-2643)GAC>AAC	p.D881N	CDK5RAP2_uc004bke.2_Missense_Mutation_p.D166N|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.D881N|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.D146N|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.D146N|CDK5RAP2_uc011lya.1_Missense_Mutation_p.D146N|CDK5RAP2_uc004bkh.1_Intron|CDK5RAP2_uc004bki.2_Missense_Mutation_p.D648N	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	881					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CTCAGCAGGTCGCCCTCCGTG	0.552000													101	158					0	0	1	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123253597	123253597	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:123253597G>A	uc004bkf.2	-	13	1651	c.1470C>T	c.(1468-1470)GAC>GAT	p.D490D	CDK5RAP2_uc004bkg.2_Silent_p.D490D|CDK5RAP2_uc011lxw.1_Translation_Start_Site|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Translation_Start_Site|CDK5RAP2_uc011lya.1_Translation_Start_Site|CDK5RAP2_uc004bkh.1_Silent_p.D490D|CDK5RAP2_uc004bki.2_Silent_p.D289D	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	490					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						GAAGCAACACGTCCTTCTGAT	0.294000													17	30					0	0	1	0	0
CEP110	11064	broad.mit.edu	37	9	123858806	123858806	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:123858806C>T	uc004bkx.1	+	4	617	c.586C>T	c.(586-588)CGA>TGA	p.R196*	CEP110_uc004bkw.2_Nonsense_Mutation_p.R196*	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	196	LRR 4.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AAAATCTTTGCGAGTCCTCAA	0.294000													40	64					0	0	1	0	0
OR5C1	392391	broad.mit.edu	37	9	125551233	125551233	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:125551233C>T	uc011lzd.1	+	1	22	c.22C>T	c.(22-24)CGG>TGG	p.R8W		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						GAACCTCACCCGGGCCGCGGT	0.502000													30	139					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126128637	126128637	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:126128637G>T	uc004bnx.1	+	4	838	c.746G>T	c.(745-747)TGT>TTT	p.C249F	CRB2_uc004bnw.1_Missense_Mutation_p.C249F	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	249	Extracellular (Potential).|EGF-like 5.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CGCTGCCTCTGTTGGCCAGGT	0.736000													13	23					4.7546e-09	4.8547e-09	1	1	0
SH2D3C	10044	broad.mit.edu	37	9	130511902	130511902	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:130511902G>A	uc004bsc.2	-	5	869	c.727C>T	c.(727-729)CGG>TGG	p.R243W	SH2D3C_uc010mxo.2_Missense_Mutation_p.R83W|SH2D3C_uc004bry.2_Missense_Mutation_p.R85W|SH2D3C_uc004brz.3_5'UTR|SH2D3C_uc011mak.1_5'UTR|SH2D3C_uc004bsa.2_Missense_Mutation_p.R86W|SH2D3C_uc004bsb.2_Missense_Mutation_p.R175W	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	243	SH2.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						AGTGAGTCCCGGATGAGGAAG	0.612000													6	15					0	0	1	0	0
TRUB2	26995	broad.mit.edu	37	9	131072049	131072049	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:131072049C>T	uc004buq.1	-	8	786	c.776G>A	c.(775-777)CGC>CAC	p.R259H		NM_015679	NP_056494	O95900	TRUB2_HUMAN	TruB pseudouridine (psi) synthase homolog 2	259					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(1)	1						GAAGCCGTCGCGCGTGCGCCG	0.582000													27	54					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131388869	131388869	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:131388869G>A	uc004bvl.3	+	48	6577	c.6464G>A	c.(6463-6465)CGC>CAC	p.R2155H	SPTAN1_uc004bvm.3_Missense_Mutation_p.R2160H|SPTAN1_uc004bvn.3_Missense_Mutation_p.R2135H|SPTAN1_uc010mye.1_5'UTR|SPTAN1_uc010myf.1_5'UTR	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2155	Spectrin 22.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GAGCTGGACCGCCAGATCAAG	0.582000													14	62					0	0	1	0	0
USP20	10868	broad.mit.edu	37	9	132631191	132631191	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:132631191G>A	uc004bys.2	+	12	1397	c.1186G>A	c.(1186-1188)GTC>ATC	p.V396I	USP20_uc004byr.2_Missense_Mutation_p.V396I|USP20_uc004byt.1_Missense_Mutation_p.V396I	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	396					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				CTGCAGCCCCGTCCACCACCA	0.672000													15	96					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133780652	133780652	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:133780652C>T	uc004bzz.2	-	6	1340	c.1095G>A	c.(1093-1095)CCG>CCA	p.P365P	FIBCD1_uc011mcc.1_Silent_p.P365P	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	365	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CCACGGTGAGCGGGTACCCGT	0.657000													15	46					0	0	1	0	0
BRD3	8019	broad.mit.edu	37	9	136910513	136910513	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:136910513C>T	uc004cew.2	-	7	1305	c.1117G>A	c.(1117-1119)GCA>ACA	p.A373T	BRD3_uc004cex.2_Missense_Mutation_p.A373T	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	373	Bromo 2.					nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		AAGCCCTGTGCGTCTGGGTAC	0.592000			T	NUT|C15orf55	lethal midline carcinoma of young people								38	230					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139401406	139401406	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:139401406G>A	uc004chz.2	-	23	3663	c.3663C>T	c.(3661-3663)AAC>AAT	p.N1221N	NOTCH1_uc004cia.1_Silent_p.N451N	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1221	Extracellular (Potential).|EGF-like 32; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGTCGTCCACGTTGATCTCAC	0.672000			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			14	24					0	0	1	0	0
CLIC3	9022	broad.mit.edu	37	9	139889178	139889178	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:139889178G>A	uc004ckj.1	-	6	695	c.666C>T	c.(664-666)AGC>AGT	p.S222S		NM_004669	NP_004660	O95833	CLIC3_HUMAN	chloride intracellular channel 3	222	GST C-terminal.				signal transduction	chloride channel complex|cytoplasm|nucleus	protein binding|voltage-gated chloride channel activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGATCTCGGCGCTGTGCGGAC	0.677000													21	24					0	0	1	0	0
TUBB2C	10383	broad.mit.edu	37	9	140137526	140137526	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:140137526G>A	uc004cmh.1	+	4	958	c.856G>A	c.(856-858)GTG>ATG	p.V286M	TUBB2C_uc004cmg.1_Missense_Mutation_p.V140M	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	286					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GGCGCTGACCGTGCCCGAGCT	0.657000													31	113					0	0	1	0	0
EHMT1	79813	broad.mit.edu	37	9	140706066	140706066	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:140706066G>A	uc011mfc.1	+	19	2903	c.2866G>A	c.(2866-2868)GTC>ATC	p.V956I		NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	956	ANK 7.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CGACTGTGTCGTGTGAGTGCA	0.642000													41	50					0	0	1	0	0
ASMTL	8623	broad.mit.edu	37	X	1536976	1536976	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:1536976C>T	uc004cpx.1	-	11	1523	c.1412G>A	c.(1411-1413)CGT>CAT	p.R471H	ASMTL_uc011mhe.1_Missense_Mutation_p.R395H|ASMTL_uc004cpy.1_Missense_Mutation_p.R455H|ASMTL_uc011mhf.1_Missense_Mutation_p.R413H	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	471	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGGGTACTCACGGGCCAGCTC	0.612000													15	45					0	0	1	0	0
FANCB	2187	broad.mit.edu	37	X	14883271	14883271	+	Missense_Mutation	SNP	C	T	T	rs142289802	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:14883271C>T	uc004cwg.1	-	3	630	c.362G>A	c.(361-363)CGT>CAT	p.R121H	FANCB_uc004cwh.1_Missense_Mutation_p.R121H	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	121					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					AAAACTCAAACGCATTTCAAA	0.313000								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				20	7					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212350	26212350	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:26212350C>T	uc004dbr.2	+	2	536	c.387C>T	c.(385-387)AAC>AAT	p.N129N	MAGEB6_uc010ngc.1_Intron	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	129	Ser-rich.									ovary(3)	3						TGGCTGCCAACGGCCAAGATG	0.557000													78	18					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149532	34149532	+	Silent	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:34149532G>A	uc004ddg.2	-	1	897	c.864C>T	c.(862-864)GAC>GAT	p.D288D		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	288										ovary(4)|central_nervous_system(1)	5						CTGTGGGTTCGTCAGTTGTCT	0.577000													13	29					0	0	1	0	0
RGN	9104	broad.mit.edu	37	X	46951573	46951573	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:46951573G>A	uc004dgz.1	+	7	1777	c.808G>A	c.(808-810)GAG>AAG	p.E270K	RGN_uc004dha.1_Missense_Mutation_p.E270K|RGN_uc010nho.1_Missense_Mutation_p.E217K|RGN_uc010nhp.1_Missense_Mutation_p.E198K	NM_152869	NP_690608	Q15493	RGN_HUMAN	regucalcin	270					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding				0						GATGGACCCCGAGGGTCTTTT	0.463000													12	2					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49088267	49088267	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:49088267G>A	uc004dnb.2	-	2	210	c.148C>T	c.(148-150)CGA>TGA	p.R50*	CACNA1F_uc010nip.2_Nonsense_Mutation_p.R50*	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	50	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	TGGTTTCTTCGCTTAGGGGTC	0.652000													6	17					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50147116	50147116	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:50147116G>A	uc010njr.1	-	5	1069	c.1009C>T	c.(1009-1011)CGG>TGG	p.R337W		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	337	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TGCTGGGTCCGGTGGCTGTAA	0.438000													19	9					0	0	1	0	0
ARHGEF9	23229	broad.mit.edu	37	X	62857963	62857963	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:62857963C>T	uc004dvl.2	-	10	2335	c.1496G>A	c.(1495-1497)CGC>CAC	p.R499H	ARHGEF9_uc004dvj.1_Missense_Mutation_p.R388H|ARHGEF9_uc004dvk.1_Missense_Mutation_p.R317H|ARHGEF9_uc011mos.1_Missense_Mutation_p.R478H|ARHGEF9_uc004dvm.1_Missense_Mutation_p.R478H|ARHGEF9_uc011mot.1_Missense_Mutation_p.R446H	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	499					apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						TGACTGGCTGCGCTTGGGTTC	0.488000													7	14					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65427138	65427138	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:65427138G>A	uc011moz.1	+	14	2462	c.2402G>A	c.(2401-2403)CGG>CAG	p.R801Q	HEPH_uc004dwn.2_Missense_Mutation_p.R801Q|HEPH_uc004dwo.2_Missense_Mutation_p.R531Q|HEPH_uc010nkr.2_Missense_Mutation_p.R609Q|HEPH_uc011mpa.1_Missense_Mutation_p.R801Q|HEPH_uc010nks.2_Missense_Mutation_p.R90Q	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	798	Extracellular (Potential).|Plastocyanin-like 5.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AGGATCCCTCGGCCAAGGACT	0.478000													5	18					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70464210	70464210	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:70464210C>A	uc004dzh.1	-	20	3309	c.3222G>T	c.(3220-3222)TGG>TGT	p.W1074C	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.W1074C|ZMYM3_uc004dzj.1_Missense_Mutation_p.W1062C	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1074					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TTGACTGCACCCAGCACTTCC	0.438000													19	22					4.96729e-08	5.04909e-08	1	1	0
POF1B	79983	broad.mit.edu	37	X	84563165	84563165	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:84563165G>A	uc004eer.2	-	10	1161	c.1015C>T	c.(1015-1017)CGG>TGG	p.R339W	POF1B_uc004ees.2_Missense_Mutation_p.R339W	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	339	Potential.						actin binding				0						AGCTCCTCCCGTATGTTGCTA	0.358000													46	11					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104999270	104999270	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:104999270T>A	uc004elz.1	+	10	2048	c.1292T>A	c.(1291-1293)CTG>CAG	p.L431Q		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	431	Cytoplasmic (Potential).|TIR.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						CTTGAAGTACTGCCAGATGTC	0.378000													30	101					0	0	1	0	0
MST4	51765	broad.mit.edu	37	X	131208175	131208175	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:131208175C>T	uc004ewk.1	+	12	1540	c.1239C>T	c.(1237-1239)GAC>GAT	p.D413D	MST4_uc004ewl.1_Silent_p.D336D|MST4_uc011mux.1_Silent_p.D435D|MST4_uc010nrj.1_Silent_p.D389D|MST4_uc004ewm.1_Silent_p.D351D	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	413					cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					GTTCAGCAGACGAATCCCCCT	0.363000													124	21					0	0	1	0	0
GDI1	2664	broad.mit.edu	37	X	153670771	153670771	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:153670771G>A	uc004fli.3	+	10	1529	c.1187G>A	c.(1186-1188)AGC>AAC	p.S396N	GDI1_uc004flj.2_Missense_Mutation_p.S61N|FAM50A_uc004fll.3_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	396					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGTTGTGAGAGCCAGGTAAGC	0.612000													131	31					0	0	1	0	0
TGIF2LY	90655	broad.mit.edu	37	Y	3447483	3447483	+	Silent	SNP	C	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrY:3447483C>T	uc004fqk.2	+	2	262	c.198C>T	c.(196-198)CGC>CGT	p.R66R		NM_139214	NP_631960	Q8IUE0	TF2LY_HUMAN	TGFB-induced factor homeobox 2-like, Y-linked	66	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGATCCTCCGCGACTGGATGT	0.468000													72	17					0	0	1	0	0
ZBTB48	3104	broad.mit.edu	37	1	6647351	6647354	+	Splice_Site	DEL	AGTA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:6647351_6647354delAGTA	uc009vmc.1	+	6	1347	c.1224_splice	c.e6+1	p.A408_splice	ZBTB48_uc001anx.2_Splice_Site_p.A408_splice|ZBTB48_uc009vmd.1_Splice_Site_p.A408_splice|ZBTB48_uc001any.1_Splice_Site_p.A46_splice	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48							cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		AGCCCCATGCAGTAAGTGACAGGG	0.564													9	66	---	---	---	---					
PHF13	148479	broad.mit.edu	37	1	6680127	6680128	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:6680127_6680128insG	uc001aob.3	+	3	777_778	c.406_407insG	c.(406-408)AGGfs	p.R136fs		NM_153812	NP_722519	Q86YI8	PHF13_HUMAN	PHD finger protein 13	136					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		AGAGGGGTACAGGGGGGGCTTG	0.525													17	155	---	---	---	---					
CLIC4	25932	broad.mit.edu	37	1	25167273	25167273	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:25167273delA	uc001bjo.2	+	6	892	c.607delA	c.(607-609)AAAfs	p.K203fs	CLIC4_uc001bjn.2_RNA|CLIC4_uc001bjp.1_Frame_Shift_Del_p.K183fs	NM_013943	NP_039234	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	203	GST C-terminal.				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		GGTGGTGGCCAAAAAATATCG	0.373													63	108	---	---	---	---					
ARID1A	8289	broad.mit.edu	37	1	27088659	27088659	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:27088659delC	uc001bmv.1	+	7	2641	c.2268delC	c.(2266-2268)AACfs	p.N756fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.N756fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.N756fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.N373fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	756					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGCAGAGGAACCCCCAGATGC	0.512			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								13	225	---	---	---	---					
DLGAP3	58512	broad.mit.edu	37	1	35365314	35365314	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:35365314delG	uc001byc.2	-	3	1342	c.1342delC	c.(1342-1344)CGGfs	p.R448fs		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	448					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				ATGGAGCTCCGGGGGTGGATC	0.577													31	205	---	---	---	---					
RNF220	55182	broad.mit.edu	37	1	45110396	45110397	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:45110396_45110397delAA	uc001clv.1	+	9	1513_1514	c.1153_1154delAA	c.(1153-1155)AAAfs	p.K385fs	RNF220_uc001clw.1_Frame_Shift_Del_p.K385fs|RNF220_uc010okx.1_Frame_Shift_Del_p.K146fs|RNF220_uc010oky.1_Frame_Shift_Del_p.K172fs|RNF220_uc010okz.1_Frame_Shift_Del_p.K127fs|RNF220_uc001clx.1_Frame_Shift_Del_p.K101fs|RNF220_uc001cly.1_Frame_Shift_Del_p.K64fs|RNF220_uc001clz.1_Frame_Shift_Del_p.K64fs|RNF220_uc001cma.1_Frame_Shift_Del_p.K64fs|TMEM53_uc001cmb.1_Intron	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	385					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GTGCAGCGGCAAAGAGAACCCG	0.599													49	115	---	---	---	---					
C1orf168	199920	broad.mit.edu	37	1	57192198	57192199	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:57192198_57192199insT	uc001cym.3	-	16	2257_2258	c.1851_1852insA	c.(1849-1854)AAAGAGfs	p.K617fs	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	617_618										ovary(3)|skin(2)	5						CCGTTTTTCTCTTTTTTTTCCT	0.312													19	109	---	---	---	---					
DBT	1629	broad.mit.edu	37	1	100684291	100684293	+	In_Frame_Del	DEL	TCT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:100684291_100684293delTCT	uc001dta.2	-	5	477_479	c.444_446delAGA	c.(442-447)GAAGAT>GAT	p.E148del	DBT_uc010oug.1_Translation_Start_Site	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	148					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TTCAACAACATCTTCTTCTGAAT	0.384													69	136	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	148891565	148891568	+	RNA	DEL	TGAC	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:148891565_148891568delTGAC	uc009wkv.1	+	9		c.867_870delTGAC								Homo sapiens cDNA, FLJ17483.																		GGTGTGTGTTTGACTGAATCAGGG	0.343													13	246	---	---	---	---					
LCE1A	353131	broad.mit.edu	37	1	152800020	152800020	+	Frame_Shift_Del	DEL	C	-	-	rs4990424		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:152800020delC	uc010pdw.1	+	1	72	c.72delC	c.(70-72)TGCfs	p.C24fs		NM_178348	NP_848125	Q5T7P2	LCE1A_HUMAN	late cornified envelope 1A	24	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ctcccaagtgccccactccta	0.413													41	154	---	---	---	---					
HCN3	57657	broad.mit.edu	37	1	155258080	155258081	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:155258080_155258081delCT	uc001fjz.1	+	8	2159_2160	c.2151_2152delCT	c.(2149-2154)CCCTCTfs	p.P717fs	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Frame_Shift_Del_p.P412fs	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	717_718	Cytoplasmic (Potential).|Pro-rich.					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCTCCCAACCCTCTCTGCCTCA	0.698													13	50	---	---	---	---					
IARS2	55699	broad.mit.edu	37	1	220307791	220307791	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:220307791delG	uc001hmc.2	+	15	1989	c.1885delG	c.(1885-1887)GGGfs	p.G629fs	IARS2_uc001hmd.2_5'Flank	NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	629					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	AGACCAGCTCGGGGGTTGGTT	0.323													8	147	---	---	---	---					
DISP1	84976	broad.mit.edu	37	1	223176292	223176293	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr1:223176292_223176293delTG	uc001hnu.1	+	8	1700_1701	c.1553_1554delTG	c.(1552-1554)ATGfs	p.M518fs		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	518	Helical; (Potential).|SSD.				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		CTTTTAGTTATGTGTGTCTACA	0.361													30	143	---	---	---	---					
TAF3	83860	broad.mit.edu	37	10	8007427	8007427	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:8007427delC	uc010qbd.1	+	3	1954	c.1954delC	c.(1954-1956)CCCfs	p.P652fs		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	652	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						AGCCCCAGCACCCCCACTGGT	0.388													61	85	---	---	---	---					
ANKRD26	22852	broad.mit.edu	37	10	27322259	27322259	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:27322259delT	uc001ith.2	-	25	3871	c.3699delA	c.(3697-3699)AAAfs	p.K1233fs	ANKRD26_uc001itg.2_Frame_Shift_Del_p.K920fs|ANKRD26_uc009xku.1_Frame_Shift_Del_p.K1234fs	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1233	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						ACATAGATTGTTTTTTTAGGG	0.313													23	63	---	---	---	---					
SVIL	6840	broad.mit.edu	37	10	29760116	29760116	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:29760116delC	uc001iut.1	-	31	6339	c.5586delG	c.(5584-5586)GGGfs	p.G1862fs	LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Frame_Shift_Del_p.G776fs|SVIL_uc001iuu.1_Frame_Shift_Del_p.G1436fs	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1862	Gelsolin-like 3.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				GCACCACCATCCCCCCCTGGA	0.527													16	21	---	---	---	---					
SVIL	6840	broad.mit.edu	37	10	29822002	29822004	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:29822002_29822004delCTT	uc001iut.1	-	8	2045_2047	c.1292_1294delAAG	c.(1291-1296)GAAGGG>GGG	p.E431del	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_In_Frame_Del_p.E431del	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	431					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				tctccttccccttcttcttcttc	0.399													12	48	---	---	---	---					
ZNF365	22891	broad.mit.edu	37	10	64159513	64159513	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:64159513delA	uc001jly.3	+	5	1296	c.1234delA	c.(1234-1236)AAAfs	p.K412fs	ZNF365_uc001jmb.3_Intron|ZNF365_uc001jmc.2_Intron|ZNF365_uc001jlz.3_Frame_Shift_Del_p.K397fs|ZNF365_uc001jma.3_RNA	NM_014951	NP_055766	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform A	Error:Variant_position_missing_in_Q70YC4_after_alignment										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					CAAAATGGCTAAAAAAAAGCC	0.527													12	45	---	---	---	---					
SLK	9748	broad.mit.edu	37	10	105727509	105727511	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:105727509_105727511delCTT	uc001kxo.1	+	1	40_42	c.6_8delCTT	c.(4-9)TCCTTC>TCC	p.F4del	SLK_uc001kxp.1_In_Frame_Del_p.F4del	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	4					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GAAAAATGTCCTTCTTCAATTTC	0.394													41	157	---	---	---	---					
PWWP2B	170394	broad.mit.edu	37	10	134218375	134218375	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:134218375delC	uc001lll.3	+	2	400	c.371delC	c.(370-372)GCCfs	p.A124fs	PWWP2B_uc009ybe.2_Frame_Shift_Del_p.A124fs	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	124	Pro-rich.										0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		TTCGAAGGCGCCCCCTTCCCT	0.751													11	29	---	---	---	---					
TUBGCP2	10844	broad.mit.edu	37	10	135103416	135103418	+	In_Frame_Del	DEL	GTT	-	-	rs141945979	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr10:135103416_135103418delGTT	uc001lmg.1	-	9	1627_1629	c.1270_1272delAAC	c.(1270-1272)AACdel	p.N424del	TUBGCP2_uc001lmf.1_In_Frame_Del_p.N17del|TUBGCP2_uc010qvc.1_In_Frame_Del_p.N452del|TUBGCP2_uc009ybk.1_In_Frame_Del_p.N424del|TUBGCP2_uc010qvd.1_In_Frame_Del_p.N294del|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	424					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		AGTACTTGTCGTTGTAATCCTCC	0.581													15	74	---	---	---	---					
IFITM1	8519	broad.mit.edu	37	11	314210	314210	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:314210delC	uc001loy.3	+	1	220	c.40delC	c.(40-42)CCCfs	p.P14fs		NM_003641	NP_003632	P13164	IFM1_HUMAN	interferon induced transmembrane protein 1	14	Extracellular (Potential).				negative regulation of cell proliferation|regulation of immune response|response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane	protein binding|receptor signaling protein activity				0		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCTGGGGCCACCCCCCAGCAC	0.562													22	136	---	---	---	---					
TSPAN4	7106	broad.mit.edu	37	11	864443	864445	+	In_Frame_Del	DEL	CTG	-	-	rs61867552	byFrequency	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:864443_864445delCTG	uc001lsd.1	+	5	471_473	c.262_264delCTG	c.(262-264)CTGdel	p.L92del	TSPAN4_uc001lse.1_In_Frame_Del_p.L28del|TSPAN4_uc001lsf.1_In_Frame_Del_p.L92del|TSPAN4_uc001lsg.1_In_Frame_Del_p.L92del|TSPAN4_uc001lsh.1_In_Frame_Del_p.L92del|TSPAN4_uc001lsi.1_In_Frame_Del_p.L92del|TSPAN4_uc001lsj.1_In_Frame_Del_p.L92del	NM_003271	NP_003262	O14817	TSN4_HUMAN	tetraspanin 4 isoform a	92	Helical; (Potential).				protein complex assembly	integral to plasma membrane				breast(1)	1		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGTTCTTCCTGCTGCTGCTGC	0.650													7	221	---	---	---	---					
QSER1	79832	broad.mit.edu	37	11	32997894	32997895	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:32997894_32997895insA	uc001mty.2	+	13	5349_5350	c.5082_5083insA	c.(5080-5085)CAGAAAfs	p.Q1694fs	QSER1_uc001mtz.1_Frame_Shift_Ins_p.Q1455fs	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1694_1695										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					CTTCGGTGCAGAAAAAAAATGA	0.292													20	45	---	---	---	---					
HIPK3	10114	broad.mit.edu	37	11	33308890	33308891	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:33308890_33308891insA	uc001mul.1	+	2	1200_1201	c.930_931insA	c.(928-933)CTGAAAfs	p.L310fs	HIPK3_uc001mum.1_Frame_Shift_Ins_p.L310fs|HIPK3_uc009yjv.1_Frame_Shift_Ins_p.L310fs	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	310_311	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						CCACTGCACTGAAAAAATTGAA	0.391													34	168	---	---	---	---					
OR8H1	219469	broad.mit.edu	37	11	56058354	56058354	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:56058354delA	uc010rje.1	-	1	185	c.185delT	c.(184-186)TTCfs	p.F62fs		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GTGAGTAAGGAAAAAATACAT	0.403													10	354	---	---	---	---					
MTA2	9219	broad.mit.edu	37	11	62362913	62362916	+	Frame_Shift_Del	DEL	GAGA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:62362913_62362916delGAGA	uc001ntq.1	-	14	1684_1687	c.1303_1306delTCTC	c.(1303-1308)TCTCCTfs	p.S435fs	MTA2_uc010rlx.1_Frame_Shift_Del_p.S262fs	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	435_436					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GTTGTGTAAGGAGAGAGACTTTGA	0.510													36	157	---	---	---	---					
SLC3A2	6520	broad.mit.edu	37	11	62649529	62649529	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:62649529delA	uc001nwd.2	+	5	1116	c.892delA	c.(892-894)AAAfs	p.K298fs	SLC3A2_uc001nwb.2_Frame_Shift_Del_p.K329fs|SLC3A2_uc001nwc.2_Frame_Shift_Del_p.K299fs|SLC3A2_uc001nwe.2_Frame_Shift_Del_p.K267fs|SLC3A2_uc001nwf.2_Frame_Shift_Del_p.K236fs|SLC3A2_uc001nwg.2_Frame_Shift_Del_p.K197fs|SLC3A2_uc010rml.1_5'Flank	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	298	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						GCAATCGGCTAAAAAAAAGAG	0.463													57	65	---	---	---	---					
RCE1	9986	broad.mit.edu	37	11	66612694	66612696	+	In_Frame_Del	DEL	TCT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:66612694_66612696delTCT	uc001ojk.1	+	6	721_723	c.677_679delTCT	c.(676-681)ATCTTC>ATC	p.F227del	RCE1_uc001ojl.1_In_Frame_Del_p.F123del	NM_005133	NP_005124	Q9Y256	FACE2_HUMAN	prenyl protein peptidase RCE1 isoform 1	227					proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			ovary(1)|breast(1)	2						GTGGGGAACATCTTCTTGTCTGC	0.527													30	52	---	---	---	---					
TBX10	347853	broad.mit.edu	37	11	67402373	67402373	+	Frame_Shift_Del	DEL	G	-	-	rs144542807		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:67402373delG	uc001omp.2	-	3	379	c.291delC	c.(289-291)CCCfs	p.P97fs		NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	97	T-box.				anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TCACCTGGAAGGGGGGGAACA	0.677													43	58	---	---	---	---					
PCF11	51585	broad.mit.edu	37	11	82877339	82877340	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:82877339_82877340delAG	uc001ozx.3	+	5	1745_1746	c.1400_1401delAG	c.(1399-1401)CAGfs	p.Q467fs	PCF11_uc010rsu.1_Frame_Shift_Del_p.Q467fs	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	467					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						TCAGAAAAACAGGGGACAAAAC	0.411													11	18	---	---	---	---					
CCDC15	80071	broad.mit.edu	37	11	124845049	124845049	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr11:124845049delA	uc001qbm.3	+	5	833	c.574delA	c.(574-576)AAAfs	p.K192fs		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	192	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AACCGTGATTAAAAAAAAGGG	0.373													9	38	---	---	---	---					
CACNB3	784	broad.mit.edu	37	12	49221502	49221504	+	In_Frame_Del	DEL	GGA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:49221502_49221504delGGA	uc001rsl.1	+	13	1476_1478	c.1275_1277delGGA	c.(1273-1278)CTGGAG>CTG	p.E427del	CACNB3_uc010sly.1_In_Frame_Del_p.E414del|CACNB3_uc010slz.1_In_Frame_Del_p.E426del|CACNB3_uc001rsk.1_In_Frame_Del_p.E274del	NM_000725	NP_000716	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3	427					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0					Verapamil(DB00661)	CCCGCCACCTGGAGGAGGACTAT	0.631													33	148	---	---	---	---					
OAS1	4938	broad.mit.edu	37	12	113354493	113354494	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr12:113354493_113354494insA	uc001tud.2	+	4	940_941	c.834_835insA	c.(832-837)TTTAAAfs	p.F278fs	OAS1_uc010syn.1_Frame_Shift_Ins_p.F277fs|OAS1_uc010syo.1_3'UTR|OAS1_uc001tub.2_Frame_Shift_Ins_p.F278fs|OAS1_uc001tuc.2_Frame_Shift_Ins_p.F278fs|OAS1_uc009zwf.2_Frame_Shift_Ins_p.F277fs	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	278_279					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2						ATTATGACTTTAAAAACCCCAT	0.431													78	125	---	---	---	---					
C14orf118	55668	broad.mit.edu	37	14	76668169	76668173	+	Frame_Shift_Del	DEL	AAGAA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:76668169_76668173delAAGAA	uc001xsh.2	+	10	1510_1514	c.1424_1428delAAGAA	c.(1423-1428)CAAGAAfs	p.Q475fs	C14orf118_uc001xsi.2_Frame_Shift_Del_p.Q470fs|C14orf118_uc001xsl.2_RNA|C14orf118_uc001xsn.1_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	475_476										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		AAAATGCCACAAGAAAAGAGCCCTG	0.488													40	49	---	---	---	---					
KIAA1409	57578	broad.mit.edu	37	14	93963615	93963615	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr14:93963615delG	uc001ybv.1	+	4	433	c.350delG	c.(349-351)AGGfs	p.R117fs	KIAA1409_uc001ybs.1_Frame_Shift_Del_p.R117fs|KIAA1409_uc001ybu.1_Intron	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	294						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AGCGAGTACAGGGGGTTGCAG	0.493													28	16	---	---	---	---					
ZNF770	54989	broad.mit.edu	37	15	35274621	35274621	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:35274621delT	uc001ziw.2	-	3	1326	c.1015delA	c.(1015-1017)ATCfs	p.I339fs		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		TTGGCCAAGATTTTTTTAACA	0.328													11	26	---	---	---	---					
IL16	3603	broad.mit.edu	37	15	81592468	81592469	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr15:81592468_81592469insC	uc002bgh.3	+	14	3177_3178	c.2801_2802insC	c.(2800-2802)CTCfs	p.L934fs	IL16_uc010blq.1_Frame_Shift_Ins_p.L888fs|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Frame_Shift_Ins_p.L976fs|IL16_uc002bgg.2_Frame_Shift_Ins_p.L934fs|IL16_uc002bgi.1_Frame_Shift_Ins_p.L324fs|IL16_uc002bgj.2_Frame_Shift_Ins_p.L428fs|IL16_uc002bgk.2_Frame_Shift_Ins_p.L233fs|IL16_uc002bgl.1_Frame_Shift_Ins_p.L233fs|IL16_uc010unq.1_Frame_Shift_Ins_p.L233fs	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	934				L -> F (in Ref. 1; AAD04636).	immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						CAGAAAACTCTCCCCCCTGGCC	0.644													10	157	---	---	---	---					
C16orf42	115939	broad.mit.edu	37	16	1400178	1400180	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:1400178_1400180delAAG	uc002cll.2	-	4	650_652	c.582_584delCTT	c.(580-585)TTCTTG>TTG	p.F194del	GNPTG_uc002clm.2_5'Flank	NM_001001410	NP_001001410	Q9UJK0	TSR3_HUMAN	hypothetical protein LOC115939	194					rRNA processing						0		Hepatocellular(780;0.0893)				GTTCAGGTCCAAGAAGCCCTTGC	0.591													21	44	---	---	---	---					
CHD9	80205	broad.mit.edu	37	16	53260306	53260307	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:53260306_53260307insA	uc002ehb.2	+	4	2089_2090	c.1925_1926insA	c.(1924-1926)AGAfs	p.R642fs	CHD9_uc002egy.2_Frame_Shift_Ins_p.R642fs|CHD9_uc002egz.1_Frame_Shift_Ins_p.R642fs|CHD9_uc002eha.1_Frame_Shift_Ins_p.R642fs|CHD9_uc002ehc.2_Frame_Shift_Ins_p.R642fs|CHD9_uc002ehd.2_Frame_Shift_Ins_p.R168fs	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	642	Lys-rich.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CAAATTAAAAGAAAAAAATACG	0.292													8	28	---	---	---	---					
FAM65A	79567	broad.mit.edu	37	16	67572573	67572575	+	Splice_Site	DEL	AGG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:67572573_67572575delAGG	uc010vjp.1	+	3	261	c.165_splice	c.e3-1	p.R55_splice	FAM65A_uc010cei.1_Splice_Site|FAM65A_uc002eth.2_Splice_Site_p.R35_splice|FAM65A_uc010cej.2_In_Frame_Del_p.R38del|FAM65A_uc002eti.1_Intron|FAM65A_uc010vjq.1_Splice_Site_p.R49_splice|FAM65A_uc002etj.1_Splice_Site_p.R34_splice|FAM65A_uc002etk.2_Splice_Site_p.R34_splice	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567							cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CCTCTCCTTCAGGAGTTTCCCGG	0.660													87	91	---	---	---	---					
NUDT7	283927	broad.mit.edu	37	16	77775744	77775744	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:77775744delA	uc010chd.2	+	4	683	c.614delA	c.(613-615)GAAfs	p.E205fs	NUDT7_uc010vnj.1_Frame_Shift_Del_p.E152fs	NM_001105663	NP_001099133	P0C024	NUDT7_HUMAN	nudix motif 7	205					nucleoside diphosphate metabolic process	peroxisome	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|magnesium ion binding|manganese ion binding			ovary(1)|kidney(1)	2						ATCATTTTGGAAAAAAAACCC	0.383													43	53	---	---	---	---					
ATMIN	23300	broad.mit.edu	37	16	81076800	81076801	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr16:81076800_81076801delTG	uc002ffz.1	+	4	715_716	c.697_698delTG	c.(697-699)TGTfs	p.C233fs	ATMIN_uc002fga.2_Frame_Shift_Del_p.C75fs|ATMIN_uc010vnn.1_Frame_Shift_Del_p.C4fs|ATMIN_uc002fgb.1_Frame_Shift_Del_p.C75fs	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	233	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding				0						AATGGAAAACTGTGCACAAAAC	0.376													22	70	---	---	---	---					
GPS2	2874	broad.mit.edu	37	17	7216932	7216935	+	Frame_Shift_Del	DEL	AGTG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:7216932_7216935delAGTG	uc002gfv.1	-	6	849_852	c.586_589delCACT	c.(586-591)CACTATfs	p.H196fs	GPS2_uc002gfw.1_Frame_Shift_Del_p.H158fs|GPS2_uc002gfx.1_Frame_Shift_Del_p.H196fs|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_Frame_Shift_Del_p.H196fs	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2	196_197					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				GTGGGCCCATAGTGAGGTGGGGGC	0.574											OREG0024133	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	103	38	---	---	---	---					
KCNAB3	9196	broad.mit.edu	37	17	7829255	7829255	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:7829255delC	uc002gjm.1	-	6	488	c.488delG	c.(487-489)GGAfs	p.G163fs	KCNAB3_uc010vul.1_RNA	NM_004732	NP_004723	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related	163						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(1)	1		Prostate(122;0.157)				TTACTGTCCTCCCCAAAAAAT	0.498													10	201	---	---	---	---					
ALDH3A1	218	broad.mit.edu	37	17	19641649	19641649	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:19641649delG	uc010cqu.2	-	9	1664	c.1334delC	c.(1333-1335)CCGfs	p.P445fs	ALDH3A1_uc010vzd.1_Frame_Shift_Del_p.P445fs|ALDH3A1_uc002gwj.2_Frame_Shift_Del_p.P445fs|ALDH3A1_uc010cqv.2_Frame_Shift_Del_p.P444fs|ALDH3A1_uc002gwk.2_Frame_Shift_Del_p.P562fs|ALDH3A1_uc002gwl.1_Frame_Shift_Del_p.P372fs	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	445					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	GGCCGGGCTCGGGGGGTATCT	0.627													139	68	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29562657	29562660	+	Frame_Shift_Del	DEL	TGTT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:29562657_29562660delTGTT	uc002hgg.2	+	28	4070_4073	c.3737_3740delTGTT	c.(3736-3741)CTGTTTfs	p.L1246fs	NF1_uc002hgh.2_Frame_Shift_Del_p.L1246fs|NF1_uc010csn.1_Frame_Shift_Del_p.L1106fs|NF1_uc002hgi.1_Frame_Shift_Del_p.L279fs	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1246_1247	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTGGTTACTCTGTTTGATTCTCGG	0.412			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			236	87	---	---	---	---					
FBXL20	84961	broad.mit.edu	37	17	37420470	37420471	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:37420470_37420471delAT	uc010wed.1	-	14	1381_1382	c.1160_1161delAT	c.(1159-1161)TATfs	p.Y387fs	FBXL20_uc002hrt.2_Frame_Shift_Del_p.Y387fs|FBXL20_uc010cvu.2_Frame_Shift_Del_p.Y355fs	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	387	LRR 12.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			GCTGGCAGTCATAGAGTTCTAT	0.480													166	77	---	---	---	---					
PLEKHH3	79990	broad.mit.edu	37	17	40820242	40820244	+	In_Frame_Del	DEL	GGA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:40820242_40820244delGGA	uc002iau.2	-	13	2750_2752	c.2283_2285delTCC	c.(2281-2286)CCTCCA>CCA	p.761_762PP>P	PLEKHH3_uc010cyl.1_RNA|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_In_Frame_Del_p.122_123PP>P|PLEKHH3_uc002iaw.2_3'UTR	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	761_762					signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GTCTTGGCATGGAGGAGAAGAGC	0.650													40	15	---	---	---	---					
MGAT5B	146664	broad.mit.edu	37	17	74878237	74878237	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:74878237delG	uc002jtg.3	+	3	500	c.186delG	c.(184-186)ATGfs	p.M62fs	MGAT5B_uc002jth.2_Frame_Shift_Del_p.M62fs|MGAT5B_uc002jti.2_Frame_Shift_Del_p.M73fs			Q3V5L5	MGT5B_HUMAN	Homo sapiens GnT-IX mRNA for N-Acetylglucosaminyltransferase IX, complete cds.	62	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						CCACAGTGATGGGGGGCCCCG	0.662													7	79	---	---	---	---					
HGS	9146	broad.mit.edu	37	17	79660715	79660717	+	In_Frame_Del	DEL	AGG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr17:79660715_79660717delAGG	uc002kbg.2	+	10	850_852	c.773_775delAGG	c.(772-777)CAGGAG>CAG	p.E262del		NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	262	Interaction with SNX1 (By similarity).|UIM.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			ACGGCCCTGCAGGAGGAGGAGGA	0.729													6	5	---	---	---	---					
ADNP2	22850	broad.mit.edu	37	18	77896426	77896426	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr18:77896426delA	uc002lnw.2	+	4	3585	c.3130delA	c.(3130-3132)AAAfs	p.K1044fs		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	1044	Homeobox.				cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		ATTAGATCCTAAAAAATATGA	0.358													34	29	---	---	---	---					
MCOLN1	57192	broad.mit.edu	37	19	7594070	7594072	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr19:7594070_7594072delCTT	uc002mgo.2	+	10	1343_1345	c.1218_1220delCTT	c.(1216-1221)ACCTTC>ACC	p.F408del	MCOLN1_uc002mgp.2_In_Frame_Del_p.F373del	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	408	Helical; (Potential).		Missing (in MLIV; mild psychomotor involvement; does not affect channel activity; affects channel inhibition by low pH; still localizes to late endosomes).		calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						GCTACCTGACCTTCTTCCACAAC	0.581													21	83	---	---	---	---					
PFN4	375189	broad.mit.edu	37	2	24344101	24344103	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:24344101_24344103delCTT	uc002rfa.1	-	3	361_363	c.185_187delAAG	c.(184-189)GAAGGA>GGA	p.E62del	LOC375190_uc002rew.2_Intron|LOC375190_uc010ykl.1_5'Flank	NM_199346	NP_955378	Q8NHR9	PROF4_HUMAN	profilin family, member 4	62					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAATACAGTCCTTCTCTTCGGGC	0.424													93	103	---	---	---	---					
MIR216A	406998	broad.mit.edu	37	2	56216156	56216157	+	RNA	DEL	CA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:56216156_56216157delCA	hsa-mir-216a|MI0000292	-			c.38_39delCA			uc002rzk.2_Intron|uc010ype.1_RNA																	0						ATGAACATCTCACAGTTGCCAG	0.480													69	140	---	---	---	---					
VPS54	51542	broad.mit.edu	37	2	64199337	64199339	+	In_Frame_Del	DEL	AGG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:64199337_64199339delAGG	uc002scq.2	-	4	581_583	c.418_420delCCT	c.(418-420)CCTdel	p.P140del	VPS54_uc002scp.2_In_Frame_Del_p.P128del|VPS54_uc010fct.2_In_Frame_Del_p.P23del	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	140					protein transport|retrograde transport, endosome to Golgi						0						AGGTATCTTTAGGAGGACAAATA	0.286													14	47	---	---	---	---					
FAHD2B	151313	broad.mit.edu	37	2	97749725	97749725	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:97749725delG	uc002sxm.2	-	7	993	c.842delC	c.(841-843)CCAfs	p.P281fs		NM_199336	NP_955368	Q6P2I3	FAH2B_HUMAN	fumarylacetoacetate hydrolase domain containing	281							hydrolase activity|metal ion binding				0						ACCGACACCTGGGGGGGTCCC	0.552													16	52	---	---	---	---					
EN1	2019	broad.mit.edu	37	2	119600797	119600799	+	In_Frame_Del	DEL	TTC	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:119600797_119600799delTTC	uc002tlm.2	-	2	1910_1912	c.894_896delGAA	c.(892-897)AAGAAC>AAC	p.K298del		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	298					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						CTCCTTCTCGTTCTTCTTCTTCT	0.680													6	11	---	---	---	---					
POTEF	728378	broad.mit.edu	37	2	130872806	130872806	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:130872806delT	uc010fmh.2	-	4	1017	c.617delA	c.(616-618)AAGfs	p.K206fs		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	206	ANK 2.					cell cortex	ATP binding			skin(3)|ovary(2)	5						AGCTGTCCTCTTTTTGTTGTC	0.403													28	86	---	---	---	---					
POTEE	445582	broad.mit.edu	37	2	132021077	132021078	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:132021077_132021078insA	uc002tsn.2	+	15	2101_2102	c.2049_2050insA	c.(2047-2052)GTGAAAfs	p.V683fs	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Frame_Shift_Ins_p.V283fs|POTEE_uc002tsl.2_Frame_Shift_Ins_p.V265fs|POTEE_uc010fmy.1_Frame_Shift_Ins_p.V147fs	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	683_684	Potential.						ATP binding				0						TTGAAAGTGTGAAAAAAAAGAA	0.416													14	24	---	---	---	---					
C2orf77	129881	broad.mit.edu	37	2	170502600	170502603	+	Frame_Shift_Del	DEL	TTCT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:170502600_170502603delTTCT	uc002ufe.2	-	9	1501_1504	c.1407_1410delAGAA	c.(1405-1410)AAAGAAfs	p.K469fs		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	469_470	Potential.										0						AGTCCTGAAATTCTTTCTCCTTTT	0.373													38	352	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179598102	179598102	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:179598102delT	uc010zfg.1	-	51	12410	c.12186delA	c.(12184-12186)AAAfs	p.K4062fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.K723fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4989							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTATTCGGTATTTTTTACTGG	0.468													86	109	---	---	---	---					
HTR2B	3357	broad.mit.edu	37	2	231973400	231973401	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr2:231973400_231973401delTT	uc002vro.2	-	4	1781_1782	c.1276_1277delAA	c.(1276-1278)AAGfs	p.K426fs	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Frame_Shift_Del_p.K359fs	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	426	Cytoplasmic (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	CTTGAAAAACTTAGAGTTCTCT	0.426													34	69	---	---	---	---					
MAVS	57506	broad.mit.edu	37	20	3845039	3845041	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:3845039_3845041delCTC	uc002wjw.3	+	6	931_933	c.762_764delCTC	c.(760-765)TTCTCC>TTC	p.S258del	MAVS_uc002wjx.3_In_Frame_Del_p.S117del|MAVS_uc002wjy.3_5'UTR	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	258	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						GCACCTCCTTCTCCTCCTCATCC	0.626													53	115	---	---	---	---					
GTSF1L	149699	broad.mit.edu	37	20	42354972	42354972	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:42354972delA	uc002xld.2	-	1	671	c.363delT	c.(361-363)TTTfs	p.F121fs	GTSF1L_uc002xlc.2_Frame_Shift_Del_p.F96fs	NM_176791	NP_789761	Q9H1H1	GTSFL_HUMAN	gametocyte specific factor 1-like isoform 1	121							metal ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCTTTTGAGGAAAAAAAGTCT	0.493													18	112	---	---	---	---					
SALL4	57167	broad.mit.edu	37	20	50400983	50400983	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:50400983delC	uc002xwh.3	-	4	3084	c.2983delG	c.(2983-2985)GTTfs	p.V995fs	SALL4_uc010gii.2_Frame_Shift_Del_p.V558fs|SALL4_uc002xwi.3_Frame_Shift_Del_p.V218fs	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	995					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AGGGTAGGAACCCCCCCACTC	0.562													24	116	---	---	---	---					
ZNF831	128611	broad.mit.edu	37	20	57769140	57769140	+	Frame_Shift_Del	DEL	G	-	-	rs55786258	by1000genomes	TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:57769140delG	uc002yan.2	+	1	3066	c.3066delG	c.(3064-3066)TTGfs	p.L1022fs		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1022						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGGCACAGTTGGGGGGGGACA	0.682													18	57	---	---	---	---					
TNFRSF6B	8771	broad.mit.edu	37	20	62328415	62328417	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr20:62328415_62328417delGAG	uc002yfy.2	+	5	729_731	c.295_297delGAG	c.(295-297)GAGdel	p.E101del	RTEL1_uc011abd.1_3'UTR|RTEL1_uc011abe.1_3'UTR|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_3'UTR|TNFRSF6B_uc002yfz.2_In_Frame_Del_p.E101del	NM_032945	NP_116563	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily,	101	TNFR-Cys 2.				anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)		Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)			CGGGGAGCGTGAGGAGGAGGCAC	0.670													9	35	---	---	---	---					
DIP2A	23181	broad.mit.edu	37	21	47954526	47954527	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr21:47954526_47954527insG	uc002zjo.2	+	13	1751_1752	c.1568_1569insG	c.(1567-1569)GTGfs	p.V523fs	DIP2A_uc011afy.1_Frame_Shift_Ins_p.V459fs|DIP2A_uc011afz.1_Frame_Shift_Ins_p.V519fs|DIP2A_uc002zjl.2_Frame_Shift_Ins_p.V523fs|DIP2A_uc002zjm.2_Frame_Shift_Ins_p.V523fs|DIP2A_uc010gql.2_Frame_Shift_Ins_p.V480fs|DIP2A_uc002zjn.2_Frame_Shift_Ins_p.V523fs|DIP2A_uc002zjp.1_Frame_Shift_Ins_p.V268fs	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	523					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GGCAGTACGGTGGGGGTCACAG	0.535													26	32	---	---	---	---					
YWHAH	7533	broad.mit.edu	37	22	32352168	32352170	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:32352168_32352170delCTC	uc003alz.2	+	2	371_373	c.130_132delCTC	c.(130-132)CTCdel	p.L45del	YWHAH_uc010gwl.2_5'UTR|YWHAH_uc003ama.2_5'UTR|YWHAH_uc010gwm.2_In_Frame_Del_p.L32del	NM_003405	NP_003396	Q04917	1433F_HUMAN	tyrosine 3-monooxygenase/tryptophan	45					glucocorticoid catabolic process|glucocorticoid receptor signaling pathway|intracellular protein transport|negative regulation of dendrite morphogenesis|positive regulation of transcription, DNA-dependent|regulation of synaptic plasticity	cytoplasm	enzyme binding|glucocorticoid receptor binding|insulin-like growth factor receptor binding|protein domain specific binding			central_nervous_system(1)	1						AGATCGAAATCTCCTCTCTGTGG	0.438													18	118	---	---	---	---					
CSF2RB	1439	broad.mit.edu	37	22	37333546	37333546	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr22:37333546delC	uc003aqa.3	+	14	1913	c.1696delC	c.(1696-1698)CCCfs	p.P566fs	CSF2RB_uc003aqc.3_Frame_Shift_Del_p.P572fs	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	566	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	CACAGAGCAGCCCCCCAGCCC	0.637													7	52	---	---	---	---					
SLC9A10	285335	broad.mit.edu	37	3	112005610	112005610	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:112005610delA	uc003dyu.2	-	2	251	c.29delT	c.(28-30)TTCfs	p.F10fs	SLC9A10_uc011bhu.1_5'UTR|SLC9A10_uc010hqc.2_Frame_Shift_Del_p.F10fs	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	10	Helical; (Potential).				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						CTCAGTACTGAAAAAAAACTC	0.353													12	33	---	---	---	---					
ZBTB20	26137	broad.mit.edu	37	3	114058003	114058003	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:114058003delG	uc003ebi.2	-	5	2255	c.2075delC	c.(2074-2076)CCTfs	p.P692fs	ZBTB20_uc003ebj.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc010hqp.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebk.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebl.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebm.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebn.2_Frame_Shift_Del_p.P619fs	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	692					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TGTGCCTGCAGGGGGGGTCCC	0.632													88	28	---	---	---	---					
NPHP3	27031	broad.mit.edu	37	3	132403500	132403502	+	In_Frame_Del	DEL	TTC	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr3:132403500_132403502delTTC	uc003epe.1	-	24	3543_3545	c.3466_3468delGAA	c.(3466-3468)GAAdel	p.E1156del	NPHP3_uc003eoz.1_In_Frame_Del_p.E35del|NPHP3_uc003epd.1_In_Frame_Del_p.E398del	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	1156	TPR 8.				maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						TTTCATAAAGTTCTTCTGCTTTA	0.419													40	20	---	---	---	---					
JAKMIP1	152789	broad.mit.edu	37	4	6052396	6052397	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr4:6052396_6052397delCT	uc010idb.1	-	14	2302_2303	c.1816_1817delAG	c.(1816-1818)AGGfs	p.R606fs	JAKMIP1_uc010idc.1_Frame_Shift_Del_p.R421fs|JAKMIP1_uc010idd.1_Intron	NM_001099433	NP_001092903	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TGGCGACCTCCTCTCTCTCTCC	0.485													3	5	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24491704	24491706	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:24491704_24491706delGAG	uc003jgr.1	-	11	2187_2189	c.1855_1857delCTC	c.(1855-1857)CTCdel	p.L619del	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	619	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TGATGATGCAGAGGAGGATGGCG	0.483										HNSCC(23;0.051)			55	110	---	---	---	---					
ERBB2IP	55914	broad.mit.edu	37	5	65371013	65371014	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:65371013_65371014insC	uc003juk.1	+	23	4226_4227	c.3918_3919insC	c.(3916-3921)CAGCCCfs	p.Q1306fs	ERBB2IP_uc003jui.1_Frame_Shift_Ins_p.Q1265fs|ERBB2IP_uc003juj.1_Intron|ERBB2IP_uc011cqx.1_Frame_Shift_Ins_p.Q1313fs|ERBB2IP_uc011cqy.1_Frame_Shift_Ins_p.Q1265fs|ERBB2IP_uc011cqz.1_Frame_Shift_Ins_p.Q504fs|ERBB2IP_uc010iwx.1_Frame_Shift_Ins_p.Q1309fs|ERBB2IP_uc003jul.1_Frame_Shift_Ins_p.Q1261fs	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	1306_1307					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		CATATACACAGCCCCATTGTTC	0.421													27	230	---	---	---	---					
PPIP5K2	23262	broad.mit.edu	37	5	102537324	102537324	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:102537324delA	uc003kod.3	+	31	4240	c.3721delA	c.(3721-3723)AAAfs	p.K1241fs	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Frame_Shift_Del_p.K1220fs|PPIP5K2_uc003kof.2_Frame_Shift_Del_p.K423fs	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	1241					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						AAACACTGGGAAAAAGAAATG	0.313													13	15	---	---	---	---					
MCC	4163	broad.mit.edu	37	5	112363035	112363037	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:112363035_112363037delCTC	uc003kqj.3	-	17	2982_2984	c.2452_2454delGAG	c.(2452-2454)GAGdel	p.E818del	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_In_Frame_Del_p.E1008del	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	818					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GCCTGGAGTTCTCCTCCTCTAGC	0.507													52	90	---	---	---	---					
KDM3B	51780	broad.mit.edu	37	5	137721747	137721749	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:137721747_137721749delAAG	uc003lcy.1	+	7	1017_1019	c.817_819delAAG	c.(817-819)AAGdel	p.K275del	KDM3B_uc010jew.1_5'UTR|KDM3B_uc011cys.1_5'Flank	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	275					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						TTCCAAAGGAAAGAAGAAGAGAG	0.419													65	142	---	---	---	---					
PSD2	84249	broad.mit.edu	37	5	139189297	139189298	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:139189297_139189298delAA	uc003leu.1	+	2	477_478	c.272_273delAA	c.(271-273)GAAfs	p.E91fs		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	91					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACATTCTGGAAGATTCAGCGG	0.619													77	150	---	---	---	---					
PCDHA12	56137	broad.mit.edu	37	5	140255597	140255601	+	Frame_Shift_Del	DEL	TAAAA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:140255597_140255601delTAAAA	uc003lic.2	+	1	667_671	c.540_544delTAAAA	c.(538-546)CTTAAAATAfs	p.L180fs	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Frame_Shift_Del_p.L180fs	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	180_182	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTTGAGCTTAAAATAAAAACAAA	0.366													20	82	---	---	---	---					
HIGD2A	192286	broad.mit.edu	37	5	175815916	175815917	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr5:175815916_175815917delAG	uc003meg.2	+	1	133_134	c.96_97delAG	c.(94-99)CCAGAGfs	p.P32fs	NOP16_uc003med.2_5'Flank|NOP16_uc003mee.2_5'Flank|NOP16_uc011dfl.1_5'Flank|NOP16_uc011dfm.1_5'Flank	NM_138820	NP_620175	Q9BW72	HIG2A_HUMAN	HIG1 hypoxia inducible domain family, member 2A	32_33	Cytoplasmic (Potential).|HIG1.					integral to membrane					0	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.0965)		ACAGGAATCCAGAGAGTTTCAA	0.564													94	154	---	---	---	---					
SNAP91	9892	broad.mit.edu	37	6	84417562	84417563	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:84417562_84417563insT	uc011dze.1	-	2	401_402	c.84_85insA	c.(82-87)AAAGCCfs	p.K28fs	SNAP91_uc003pkb.2_5'UTR|SNAP91_uc003pkc.2_Frame_Shift_Ins_p.K28fs|SNAP91_uc003pkd.2_Frame_Shift_Ins_p.K28fs|SNAP91_uc003pka.2_Frame_Shift_Ins_p.K28fs|SNAP91_uc011dzf.1_5'UTR	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	28_29	ENTH.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TGAGTAGTGGCTTTGCAGACCG	0.559													98	57	---	---	---	---					
LATS1	9113	broad.mit.edu	37	6	150005515	150005515	+	Frame_Shift_Del	DEL	G	-	-	rs56149740		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr6:150005515delG	uc003qmu.1	-	4	1258	c.710delC	c.(709-711)CCAfs	p.P237fs	LATS1_uc010kif.1_Frame_Shift_Del_p.P132fs|LATS1_uc003qmv.1_Frame_Shift_Del_p.P237fs|LATS1_uc003qmw.2_Frame_Shift_Del_p.P237fs|LATS1_uc010kig.1_Frame_Shift_Del_p.P132fs	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	237					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AGGTGGTGGTGGGGGGTTCAC	0.532													18	149	---	---	---	---					
FKBP9	11328	broad.mit.edu	37	7	33014804	33014804	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:33014804delC	uc003tdh.2	+	3	559	c.378delC	c.(376-378)ATCfs	p.I126fs	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Frame_Shift_Del_p.I179fs|FKBP9_uc003tdg.2_Frame_Shift_Del_p.I126fs|FKBP9_uc010kwm.2_Frame_Shift_Del_p.I33fs	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	126	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			CTGGTGTGATCCCCCCCAATT	0.443													33	71	---	---	---	---					
PON1	5444	broad.mit.edu	37	7	94931546	94931548	+	In_Frame_Del	DEL	AGA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:94931546_94931548delAGA	uc003uns.2	-	8	975_977	c.878_880delTCT	c.(877-882)TTCTAT>TAT	p.F293del	PON1_uc011kih.1_In_Frame_Del_p.F293del	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	293					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TCTGAGTCATAGAAGAAGATTTT	0.399													20	108	---	---	---	---					
MCM7	4176	broad.mit.edu	37	7	99690987	99690989	+	In_Frame_Del	DEL	TCT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:99690987_99690989delTCT	uc003usw.1	-	14	2394_2396	c.1884_1886delAGA	c.(1882-1887)GAAGAT>GAT	p.E628del	MCM7_uc003usv.1_In_Frame_Del_p.E452del|MCM7_uc003usx.1_In_Frame_Del_p.E452del	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	628	Interaction with ATRIP.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	TTCATTCACATCTTCTTTCTCCA	0.527													107	209	---	---	---	---					
SLC13A4	26266	broad.mit.edu	37	7	135375977	135375977	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:135375977delC	uc003vta.2	-	13	2104	c.1415delG	c.(1414-1416)GGAfs	p.G472fs	SLC13A4_uc003vtb.2_Frame_Shift_Del_p.G473fs|PL-5283_uc003vsz.3_Intron	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	472	Helical; (Potential).					integral to plasma membrane	sodium:sulfate symporter activity				0						AGCATAGCCTCCCCCAACCAG	0.393													36	62	---	---	---	---					
EPHB6	2051	broad.mit.edu	37	7	142561447	142561448	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:142561447_142561448insG	uc011kst.1	+	6	946_947	c.159_160insG	c.(157-162)CCAGGGfs	p.P53fs	EPHB6_uc011ksu.1_Frame_Shift_Ins_p.P53fs|EPHB6_uc003wbs.2_Intron|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Intron	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	53_54	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CCTACCCACCAGGGGGGGTGAG	0.574													7	165	---	---	---	---					
SLC4A2	6522	broad.mit.edu	37	7	150761737	150761737	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr7:150761737delG	uc003wit.3	+	4	598	c.342delG	c.(340-342)CCGfs	p.P114fs	SLC4A2_uc011kve.1_Frame_Shift_Del_p.P105fs|SLC4A2_uc003wiu.3_Frame_Shift_Del_p.P100fs	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	114	Cytoplasmic (Potential).|Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAGCCTCCCCGACTGGAGAAA	0.687													35	61	---	---	---	---					
CLU	1191	broad.mit.edu	37	8	27468075	27468076	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:27468075_27468076delAG	uc003xfw.1	-	1	71_72	c.13_14delCT	c.(13-15)CTGfs	p.L5fs	CLU_uc010lux.1_5'UTR|CLU_uc003xfx.1_Frame_Shift_Del_p.L5fs|CLU_uc003xfy.1_Frame_Shift_Del_p.L16fs|CLU_uc003xfz.1_Frame_Shift_Del_p.L57fs	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2	5					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		AAACAGCAGCAGAGTCTTCATC	0.584													28	41	---	---	---	---					
MTFR1	9650	broad.mit.edu	37	8	66620197	66620197	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:66620197delA	uc003xvm.2	+	7	1096	c.884delA	c.(883-885)GAAfs	p.E295fs	MTFR1_uc011lep.1_Frame_Shift_Del_p.E295fs|MTFR1_uc003xvn.2_Frame_Shift_Del_p.E262fs|MTFR1_uc003xvo.1_Frame_Shift_Del_p.E285fs	NM_014637	NP_055452	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1 isoform 1	295						mitochondrion|plasma membrane				pancreas(1)	1			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			GATGAAGTTGAAAAAGGAATT	0.443													43	125	---	---	---	---					
VPS13B	157680	broad.mit.edu	37	8	100796702	100796702	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:100796702delC	uc003yiv.2	+	43	8125	c.8014delC	c.(8014-8016)CAGfs	p.Q2672fs	VPS13B_uc003yiw.2_Frame_Shift_Del_p.Q2647fs	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2672					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAAATCCCCACAGGTATTTGA	0.468													39	69	---	---	---	---					
WDR67	93594	broad.mit.edu	37	8	124105886	124105886	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr8:124105886delT	uc003ypp.1	+	5	665	c.575delT	c.(574-576)ATTfs	p.I192fs	WDR67_uc011lig.1_Frame_Shift_Del_p.I192fs|WDR67_uc011lih.1_Frame_Shift_Del_p.I82fs|WDR67_uc003ypq.1_RNA|WDR67_uc003ypo.1_Frame_Shift_Del_p.I192fs|WDR67_uc003ypr.2_RNA	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	192	WD 3.					centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GATAATTCCATTTTTGCCTGG	0.348													18	42	---	---	---	---					
FOXD4	2298	broad.mit.edu	37	9	117366	117367	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:117366_117367insG	uc003zfz.2	-	1	1051_1052	c.753_754insC	c.(751-756)CCCGGGfs	p.P251fs		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	251_252	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GGGCGTCTCCCGGGGCCGGTGT	0.728													8	69	---	---	---	---					
CCIN	881	broad.mit.edu	37	9	36170732	36170732	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:36170732delC	uc003zzb.3	+	1	1344	c.1233delC	c.(1231-1233)ATCfs	p.I411fs		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	411	Kelch 3.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			AGATGAGCATCCCCATGGATG	0.552													21	141	---	---	---	---					
RGS3	5998	broad.mit.edu	37	9	116246504	116246506	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:116246504_116246506delCTT	uc004bhq.2	+	7	821_823	c.612_614delCTT	c.(610-615)CACTTC>CAC	p.F207del	RGS3_uc004bhr.2_In_Frame_Del_p.F95del|RGS3_uc004bhs.2_In_Frame_Del_p.F97del	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	207	C2.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						TCCACGAGCACTTCTTCTTGTAA	0.473													38	77	---	---	---	---					
PHF19	26147	broad.mit.edu	37	9	123624994	123624996	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:123624994_123624996delCTT	uc004bks.1	-	11	1253_1255	c.1000_1002delAAG	c.(1000-1002)AAGdel	p.K334del	PHF19_uc011lyf.1_In_Frame_Del_p.K125del|PHF19_uc004bkr.2_RNA	NM_015651	NP_056466	Q5T6S3	PHF19_HUMAN	PHD finger protein 19 isoform a	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|breast(1)	2						GGAAGATGCACTTCTTCTTCTTG	0.606													64	374	---	---	---	---					
KIAA0649	9858	broad.mit.edu	37	9	138379043	138379043	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chr9:138379043delG	uc004cfr.1	+	4	3236	c.2687delG	c.(2686-2688)AGGfs	p.R896fs		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	896						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		CAGAGGGCCAGGGGGGTCCCA	0.701													71	137	---	---	---	---					
SHROOM2	357	broad.mit.edu	37	X	9900853	9900853	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:9900853delC	uc004csu.1	+	6	3620	c.3530delC	c.(3529-3531)GCCfs	p.A1177fs	SHROOM2_uc004csv.2_Frame_Shift_Del_p.A12fs|SHROOM2_uc011mic.1_Frame_Shift_Del_p.A12fs|SHROOM2_uc004csw.1_Frame_Shift_Del_p.A12fs	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1177					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CCCCAGTTCGCCCCCCAGAAA	0.627													23	43	---	---	---	---					
ACOT9	23597	broad.mit.edu	37	X	23723697	23723698	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:23723697_23723698insA	uc004dap.2	-	12	1066_1067	c.920_921insT	c.(919-921)TTCfs	p.F307fs	ACOT9_uc004dan.2_Frame_Shift_Ins_p.F57fs|ACOT9_uc004dao.2_Frame_Shift_Ins_p.F316fs|ACOT9_uc004daq.2_Frame_Shift_Ins_p.F265fs|ACOT9_uc004dar.2_Frame_Shift_Ins_p.F247fs|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Frame_Shift_Ins_p.F247fs	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	307					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						AGATCCGATTGAAAATGTTCCG	0.401													97	36	---	---	---	---					
POU3F4	5456	broad.mit.edu	37	X	82764415	82764418	+	Frame_Shift_Del	DEL	CTGA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:82764415_82764418delCTGA	uc004eeg.2	+	1	1147_1150	c.1083_1086delCTGA	c.(1081-1086)CTCTGAfs	p.L361fs		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	361_362					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCATGATCTCTGACTGGAGGAAG	0.412													12	5	---	---	---	---					
IRS4	8471	broad.mit.edu	37	X	107977802	107977803	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:107977802_107977803insC	uc004eoc.2	-	1	1805_1806	c.1772_1773insG	c.(1771-1773)GGCfs	p.G591fs		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	591						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTGAGCCTTTGCCCCCCCCAGA	0.545													8	566	---	---	---	---					
SLC6A14	11254	broad.mit.edu	37	X	115582769	115582770	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:115582769_115582770insT	uc004eqi.2	+	8	1197_1198	c.1093_1094insT	c.(1093-1095)ATTfs	p.I365fs		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	365	Helical; Name=7; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TGGATTTGCTATTTTTTCTATA	0.332													157	50	---	---	---	---					
USP26	83844	broad.mit.edu	37	X	132161205	132161205	+	Frame_Shift_Del	DEL	A	-	-	rs61758857		TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:132161205delA	uc010nrm.1	-	6	1514	c.1044delT	c.(1042-1044)TTTfs	p.F348fs	USP26_uc011mvf.1_Frame_Shift_Del_p.F348fs	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	348					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					AGGTATCTTTAAAAAAAAGTA	0.388													84	37	---	---	---	---					
ATP11C	286410	broad.mit.edu	37	X	138869332	138869334	+	In_Frame_Del	DEL	TCT	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:138869332_138869334delTCT	uc004faz.2	-	15	1698_1700	c.1599_1601delAGA	c.(1597-1602)GAAGAA>GAA	p.533_534EE>E	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_In_Frame_Del_p.533_534EE>E	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	533_534	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					AGCTACTTACTCTTCTATTTCTT	0.345													28	14	---	---	---	---					
FAM50A	9130	broad.mit.edu	37	X	153678435	153678437	+	In_Frame_Del	DEL	GGA	-	-			TCGA-HT-8564-01A-11D-2395-08	TCGA-HT-8564-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41cf33f-58da-40f9-890d-cec026fe2f70	7bdf8707-ae9f-433e-837e-789e5883a173	g.chrX:153678435_153678437delGGA	uc004fll.3	+	11	986_988	c.888_890delGGA	c.(886-891)GTGGAG>GTG	p.E297del		NM_004699	NP_004690	Q14320	FA50A_HUMAN	XAP-5 protein	297					spermatogenesis	nucleus				ovary(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACGCCACTGTGGAGAAGGATGAG	0.616													93	63	---	---	---	---					
