Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	qox	pox_cutoff	pox	oxoGCut	isArtifactMode	t_ref_count	t_alt_count
BTBD7	55727	broad.mit.edu	37	14	93723588	93723588	+	Missense_Mutation	SNP	G	C	C			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr14:93723588G>C	uc001ybo.3	-	5	1887	c.1561C>G	c.(1561-1563)Cga>Gga	p.R521G	BTBD7_uc010aur.3_Missense_Mutation_p.R46G|BTBD7_uc010two.2_Missense_Mutation_p.R341G|BTBD7_uc001ybp.3_Missense_Mutation_p.R170G|BTBD7_uc001ybq.4_Missense_Mutation_p.R436G	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	Homo sapiens BTB (POZ) domain containing 7 (BTBD7), transcript variant 1, mRNA.	521								p.R521L(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		TGTTCAATTCGCACAAAAGGT	0.408													0	1.48E-04	0	0	0	75	55
FREM1	158326	broad.mit.edu	37	9	14759843	14759843	+	Missense_Mutation	SNP	T	C	C			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr9:14759843T>C	uc003zlm.3	-	28	6077	c.5261A>G	c.(5260-5262)gAg>gGg	p.E1754G	FREM1_uc010mic.3_Intron|FREM1_uc003zlk.3_Non-coding_Transcript|FREM1_uc003zll.3_Missense_Mutation_p.E290G	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant 1, mRNA.	1754	Calx-beta.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		ACCCACATTCTCACAGACTTC	0.388													0	1.32E-04	0	0	0	29	20
RIC3	79608	broad.mit.edu	37	11	8190434	8190434	+	Missense_Mutation	SNP	C	T	T			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr11:8190434C>T	uc010rbm.1	-	0	157	c.103G>A	c.(103-105)Gag>Aag	p.E35K	RIC3_uc010rbl.1_5'UTR|RIC3_uc001mgd.2_Missense_Mutation_p.E35K|RIC3_uc001mgc.2_Missense_Mutation_p.E35K|RIC3_uc009yfm.2_Missense_Mutation_p.E35K|RIC3_uc001mge.2_Missense_Mutation_p.E35K|RIC3_uc009yfn.2_5'UTR|RIC3_uc001mgf.4_Missense_Mutation_p.E35K	NM_024557	NP_001193600	Q7Z5B4	RIC3_HUMAN	Homo sapiens resistance to inhibitors of cholinesterase 3 homolog (C. elegans) (RIC3), transcript variant 1, mRNA.	35						Golgi membrane|endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)	17				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		GGCGGCGGCTCCTGCCGCTTC	0.657													0	6.40E-05	0	0	0	7	6
DAAM1	23002	broad.mit.edu	37	14	59789679	59789679	+	Silent	SNP	C	T	T			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr14:59789679C>T	uc001xdz.1	+	5	635	c.510C>T	c.(508-510)taC>taT	p.Y170Y	DAAM1_uc001xea.1_Silent_p.Y170Y|DAAM1_uc001xeb.1_Silent_p.Y170Y	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	Homo sapiens dishevelled associated activator of morphogenesis 1 (DAAM1), mRNA.	170	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	Rho GTPase binding|actin binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CCATGGACTACGAGACCTCAG	0.448													0	1.48E-04	0	0	0	67	58
PDCD1	5133	broad.mit.edu	37	2	242794494	242794494	+	Missense_Mutation	SNP	C	T	T			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr2:242794494C>T	uc002wcq.4	-	2	516	c.448G>A	c.(448-450)Gaa>Aaa	p.E150K	PDCD1_uc010fzs.3_Intron|PDCD1_uc010fzt.3_Non-coding_Transcript	NM_005018	NP_005009	Q15116	PDCD1_HUMAN	Homo sapiens programmed cell death 1 (PDCD1), mRNA.	150					T cell costimulation|apoptosis|humoral immune response|multicellular organismal development	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			endometrium(1)|lung(2)|ovary(1)|prostate(3)|skin(1)	8		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		GTGGGCACTTCTGCCCTTCTC	0.677													0	3.86E-05	0	0	0	21	9
CELF5	60680	broad.mit.edu	37	19	3282183	3282183	+	Silent	SNP	G	C	C			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr19:3282183G>C	uc002lxm.3	+	6	847	c.810G>C	c.(808-810)gtG>gtC	p.V270V	CELF5_uc010dtj.2_Silent_p.V270V|CELF5_uc002lxl.2_Silent_p.V270V|CELF5_uc010xhg.2_Non-coding_Transcript|CELF5_uc002lxn.3_Non-coding_Transcript	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	Homo sapiens CUGBP, Elav-like family member 5 (CELF5), transcript variant 1, mRNA.	270					mRNA processing	cytoplasm|nucleus	RNA binding|nucleotide binding			kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)	13						GTCCCGGCGTGGCCTTCTCAC	0.622													0	1.48E-04	0	0	0	118	64
TMEM66	51669	broad.mit.edu	37	8	29927254	29927254	+	Missense_Mutation	SNP	G	T	T			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr8:29927254G>T	uc003xhs.3	-	2	788	c.604C>A	c.(604-606)Cca>Aca	p.P202T	MIR548O2_uc022atm.1_Intron|TMEM66_uc003xhv.3_Missense_Mutation_p.P30T	NM_016127	NP_057211	Q96BY9	TMM66_HUMAN	Homo sapiens transmembrane protein 66 (TMEM66), mRNA.	202						integral to membrane				endometrium(2)|large_intestine(1)|lung(11)	14				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		GAGTACGGTGGAGGAGAATAC	0.488													2.24E-13	4.10E-04	3.90E-15	0	1	83	32
NPBWR2	2832	broad.mit.edu	37	20	62737969	62737969	+	Missense_Mutation	SNP	C	A	A			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr20:62737969C>A	uc011abt.2	-	0	216	c.216G>T	c.(214-216)agG>agT	p.R72S		NM_005286	NP_005277	P48146	NPBW2_HUMAN	Homo sapiens neuropeptides B/W receptor 2 (NPBWR2), mRNA.	72						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					TCTTGGGCGCCCTTAGGATTA	0.617													2.40E-08	4.10E-04	4.32E-10	0	1	25	33
IL17REL	400935	broad.mit.edu	37	22	50436654	50436654	+	Missense_Mutation	SNP	A	G	G			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr22:50436654A>G	uc003bje.1	-	9	918	c.686T>C	c.(685-687)gTg>gCg	p.V229A		NM_001001694	NP_001001694	Q6ZVW7	I17EL_HUMAN	Homo sapiens interleukin 17 receptor E-like (IL17REL), mRNA.	229										endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		ATGGCCACTCACAGGGCAGGC	0.677													0	2.48E-04	0	0	0	78	3
ALPK2	115701	broad.mit.edu	37	18	56204584	56204584	+	Silent	SNP	G	C	C			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr18:56204584G>C	uc002lhj.4	-	4	3049	c.2835C>G	c.(2833-2835)ctC>ctG	p.L945L	ALPK2_uc002lhk.1_Silent_p.L276L	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	Homo sapiens alpha-kinase 2 (ALPK2), mRNA.	945							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CAGAAGAAAGGAGCTGTGTTT	0.532													0	2.19E-04	0	0	0	11	15
TSC22D1	8848	broad.mit.edu	37	13	45149845	45149845	+	Silent	SNP	G	C	C			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr13:45149845G>C	uc001uzn.4	-	0	857	c.366C>G	c.(364-366)tcC>tcG	p.S122S	TSC22D1_uc001uzo.2_Silent_p.S122S|TSC22D1-AS1_uc021rjb.1_5'Flank	NM_183422	NP_904358	Q15714	T22D1_HUMAN	Homo sapiens TSC22 domain family, member 1 (TSC22D1), transcript variant 1, mRNA.	122					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity	p.S122S(2)		breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TGATACTAGCGGAGATCTGAG	0.493													0	1.48E-04	0	0	0	151	127
ABHD4	63874	broad.mit.edu	37	14	23075421	23075421	+	Missense_Mutation	SNP	G	A	A			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr14:23075421G>A	uc001wgm.3	+	4	803	c.734G>A	c.(733-735)tGc>tAc	p.C245Y	ABHD4_uc010tna.1_Missense_Mutation_p.A272T|ABHD4_uc010tnb.2_Non-coding_Transcript	NM_022060	NP_071343	Q8TB40	ABHD4_HUMAN	Homo sapiens abhydrolase domain containing 4 (ABHD4), mRNA.	245					lipid catabolic process		hydrolase activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(3)|prostate(1)	14	all_cancers(95;5.49e-05)			GBM - Glioblastoma multiforme(265;0.0153)		ATTTACCACTGCAACGCACAG	0.522													0	1.01E-04	0	0	0	10	13
RIMS2	9699	broad.mit.edu	37	8	105261014	105261014	+	Missense_Mutation	SNP	C	T	T			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr8:105261014C>T	uc003yls.3	+	24	3857	c.3616C>T	c.(3616-3618)Cgc>Tgc	p.R1206C	RIMS2_uc003ylp.3_Missense_Mutation_p.R1188C|RIMS2_uc003ylw.2_Missense_Mutation_p.R1195C|RIMS2_uc003ylq.3_Missense_Mutation_p.R1002C|RIMS2_uc003ylr.3_Missense_Mutation_p.R1027C	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	Homo sapiens regulating synaptic membrane exocytosis 2 (RIMS2), transcript variant 2, mRNA.	1250					intracellular protein transport	cell junction|presynaptic membrane	Rab GTPase binding|metal ion binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GCTAGTGGGACGCCAGACTCT	0.428										HNSCC(12;0.0054)			0	1.32E-04	0	0	0	30	17
NCOR1	9611	broad.mit.edu	37	17	15983374	15983374	+	Silent	SNP	G	A	A			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr17:15983374G>A	uc002gpo.3	-	25	3674	c.3405C>T	c.(3403-3405)acC>acT	p.T1135T	NCOR1_uc002gpn.3_Silent_p.T1151T|NCOR1_uc002gpp.1_Silent_p.T1042T|NCOR1_uc010vwb.2_5'UTR|NCOR1_uc010coy.3_Silent_p.T43T|NCOR1_uc010vwc.2_5'UTR	NM_006311	NP_006302	O75376	NCOR1_HUMAN	Homo sapiens nuclear receptor corepressor 1 (NCOR1), transcript variant 1, mRNA.	1135	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TGGCTCCTGCGGTACCTGAAT	0.463													0	2.28E-04	0	0	0	29	28
LSAMP	4045	broad.mit.edu	37	3	115561414	115561414	+	Missense_Mutation	SNP	T	C	C			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr3:115561414T>C	uc011bis.2	-	4	1168	c.661A>G	c.(661-663)Atc>Gtc	p.I221V	LSAMP_uc003ebs.3_Missense_Mutation_p.I221V	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	Homo sapiens limbic system-associated membrane protein (LSAMP), mRNA.	221	Ig-like C2-type 3.				cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GATTCTGTGATAGTGGGAGGA	0.493													0	1.01E-04	0	0	0	19	13
NPEPPS	9520	broad.mit.edu	37	17	45608849	45608849	+	Missense_Mutation	SNP	C	G	G			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr17:45608849C>G	uc002ilr.4	+	0	406	c.183C>G	c.(181-183)atC>atG	p.I61M	NPEPPS_uc010wkt.2_Missense_Mutation_p.I57M|NPEPPS_uc010wku.2_Missense_Mutation_p.I61M	NM_006310	NP_006301	P55786	PSA_HUMAN	Homo sapiens aminopeptidase puromycin sensitive (NPEPPS), mRNA.	61					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						TCTCCCCCATCAACTACAGCC	0.687													0	1.57E-04	0	0	0	8	7
STON2	85439	broad.mit.edu	37	14	81744032	81744032	+	Silent	SNP	G	A	A			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr14:81744032G>A	uc010tvu.2	-	3	1821	c.1623C>T	c.(1621-1623)ttC>ttT	p.F541F	STON2_uc001xvk.1_Silent_p.F541F|STON2_uc010tvt.2_Silent_p.F338F	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	Homo sapiens stonin 2 (STON2), transcript variant 1, mRNA.	541	SHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		CTGCATGGATGAAACTCAGGA	0.498													0	1.48E-04	0	0	0	66	50
PLXDC2	84898	broad.mit.edu	37	10	20500614	20500614	+	Missense_Mutation	SNP	G	C	C			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr10:20500614G>C	uc001iqg.1	+	9	1715	c.1078G>C	c.(1078-1080)Gat>Cat	p.D360H	PLXDC2_uc001iqh.1_Missense_Mutation_p.D311H|PLXDC2_uc009xkc.1_Intron	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	Homo sapiens plexin domain containing 2 (PLXDC2), mRNA.	360	PSI.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						CAGTGGATTTGATCGTCATCG	0.443													0	1.57E-04	0	0	0	6	4
ZNF618	114991	broad.mit.edu	37	9	116811046	116811046	+	Silent	SNP	C	T	T			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr9:116811046C>T	uc004bid.3	+	14	1563	c.1464C>T	c.(1462-1464)agC>agT	p.S488S	ZNF618_uc004bic.3_Silent_p.S395S|ZNF618_uc011lxi.2_Silent_p.S455S|ZNF618_uc011lxj.2_Silent_p.S456S|ZNF618_uc010mvb.3_Silent_p.S78S	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	Homo sapiens zinc finger protein 618 (ZNF618), mRNA.	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						GCGTGGTCAGCGGGAAGGAGT	0.582													0	3.39E-04	0	0	0	67	33
ACAD10	80724	broad.mit.edu	37	12	112182761	112182761	+	Missense_Mutation	SNP	C	G	G			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr12:112182761C>G	uc009zvx.3	+	13	2322	c.2122C>G	c.(2122-2124)Cgt>Ggt	p.R708G	ACAD10_uc001tsp.3_Missense_Mutation_p.R677G|ACAD10_uc001tsq.3_Missense_Mutation_p.R677G|ACAD10_uc001tss.1_Non-coding_Transcript	NM_001136538	NP_001130010	Q6JQN1	ACD10_HUMAN	Homo sapiens acyl-CoA dehydrogenase family, member 10 (ACAD10), transcript variant 1, mRNA.	677							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CATGGAGCAACGTGTGTACCC	0.582													0	1.48E-04	0	0	0	48	57
NUP93	9688	broad.mit.edu	37	16	56782202	56782202	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr16:56782202C>T	uc002eka.3	+	1	164	c.43C>T	c.(43-45)Cag>Tag	p.Q15*		NM_014669	NP_001229725	Q8N1F7	NUP93_HUMAN	Homo sapiens nucleoporin 93kDa (NUP93), transcript variant 1, mRNA.	15					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.E14K(3)|p.Q15*(2)		breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						GCAAGCTGAACAGCTTGCTGC	0.517													0	3.39E-04	0	0	0	74	31
CCL13	6357	broad.mit.edu	37	17	32683581	32683581	+	Silent	SNP	C	G	G			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr17:32683581C>G	uc002hic.3	+	0	111	c.36C>G	c.(34-36)ctC>ctG	p.L12L		NM_005408	NP_005399	Q99616	CCL13_HUMAN	Homo sapiens chemokine (C-C motif) ligand 13 (CCL13), mRNA.	12					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|prostate(1)	2		Ovarian(249;0.0443)|Breast(31;0.151)				GCCTGCTGCTCATGACAGCAG	0.502													0	5.86E-04	0	0	0	26	22
TECPR2	9895	broad.mit.edu	37	14	102873742	102873742	+	Missense_Mutation	SNP	C	T	T			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr14:102873742C>T	uc001ylw.2	+	2	513	c.287C>T	c.(286-288)aCa>aTa	p.T96I	TECPR2_uc010txw.2_Missense_Mutation_p.T96I|TECPR2_uc010awl.3_Missense_Mutation_p.T96I|TECPR2_uc010txx.2_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	Homo sapiens tectonin beta-propeller repeat containing 2 (TECPR2), transcript variant 1, mRNA.	96							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						GCAGCAGGCACAGCCTCTGGC	0.463													0	1.48E-04	0	0	0	36	54
NDUFS5	4725	broad.mit.edu	37	1	39494585	39494586	+	Frame_Shift_Ins	INS	-	TA	TA			TCGA-BJ-A191-01A-11D-A13W-08	TCGA-BJ-A191-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c2e6a0-2341-49c4-a6dd-656e7bb505dd	62c780b8-c3a9-4c61-a1bc-18a80c5ca48d	g.chr1:39494585_39494586insTA	uc001ccx.3	+	1	299_300	c.189_190insTA	c.(187-192)ttcgtafs	p.F63fs	NDUFS5_uc001ccy.3_Frame_Shift_Ins_p.F63fs	NM_004552	NP_004543	O43920	NDUS5_HUMAN	Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) (NDUFS5), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	63					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity	p.D62Y(1)		endometrium(1)|kidney(1)|large_intestine(2)|upper_aerodigestive_tract(1)	5	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.93e-18)		NADH(DB00157)	ATGATGATTTCGTAGAGTGTTT	0.396																		74	69
