Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	qox	pox_cutoff	pox	oxoGCut	isArtifactMode	t_ref_count	t_alt_count
MUC16	94025	broad.mit.edu	37	19	9090831	9090831	+	Silent	SNP	A	G	G			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr19:9090831A>G	uc002mkp.3	-	0	1188	c.984T>C	c.(982-984)ccT>ccC	p.P328P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.	328	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCATGGAAAAAGGGATAGCTG	0.522													0	1	0	0	0	100	3
TNR	7143	broad.mit.edu	37	1	175325475	175325475	+	Missense_Mutation	SNP	A	T	T			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr1:175325475A>T	uc001gkp.1	-	13	3179	c.3098T>A	c.(3097-3099)aTc>aAc	p.I1033N	TNR_uc009wwu.1_Missense_Mutation_p.I1033N	NM_003285	NP_003276	Q92752	TENR_HUMAN	Homo sapiens tenascin R (restrictin, janusin) (TNR), mRNA.	1033	Fibronectin type-III 8.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GTTGGTGCTGATGGTGCCACT	0.498													0	1	0	0	0	164	30
KCNA4	3739	broad.mit.edu	37	11	30033580	30033580	+	Missense_Mutation	SNP	G	A	A			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr11:30033580G>A	uc021qfi.1	-	0	646	c.646C>T	c.(646-648)Cgc>Tgc	p.R216C	KCNA4_uc001msk.3_Missense_Mutation_p.R216C	NM_002233	NP_002224	P22459	KCNA4_HUMAN	Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 4 (KCNA4), mRNA.	216						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						TACTCATTGCGCAAAGGGTCA	0.483													0	1	0	0	0	101	4
ADAMTS7	11173	broad.mit.edu	37	15	79056079	79056079	+	Missense_Mutation	SNP	G	T	T			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr15:79056079G>T	uc002bej.4	-	21	4913	c.4702C>A	c.(4702-4704)Cac>Aac	p.H1568N		NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 7 (ADAMTS7), mRNA.	1568					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GTGCAGGGGTGGGTGTTGCAG	0.711													1	1	1	0	1	32	3
GNAS	2778	broad.mit.edu	37	20	57429071	57429071	+	Missense_Mutation	SNP	G	C	C			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr20:57429071G>C	uc002xzw.3	+	0	1036	c.751G>C	c.(751-753)Ggc>Cgc	p.G251R	GNAS_uc021wfl.1_Intron|GNAS_uc002xzt.3_Intron|GNAS_uc010gjq.3_Intron|GNAS_uc002xzv.3_Non-coding_Transcript	NM_080425	NP_001070958	P63092	GNAS2_HUMAN	Homo sapiens GNAS complex locus (GNAS), transcript variant 2, mRNA.	0					G-protein coupled receptor protein signaling pathway|activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	GTP binding|GTPase activity|adenylate cyclase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			ACAAGTCGACGGCAGCAGCCA	0.677			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			0	1	0	0	0	14	15
HCCS	3052	broad.mit.edu	37	X	11139095	11139095	+	Missense_Mutation	SNP	G	A	A			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chrX:11139095G>A	uc004cul.2	+	5	770	c.590G>A	c.(589-591)cGa>cAa	p.R197Q	HCCS_uc004cuk.3_Missense_Mutation_p.R197Q|HCCS_uc004cuj.3_Missense_Mutation_p.R197Q	NM_001171991	NP_005324	P53701	CCHL_HUMAN	Homo sapiens holocytochrome c synthase (HCCS), transcript variant 3, mRNA.	197					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)	7						CCAAGGGCACGAATTCGTTCC	0.453													0	1	0	0	0	244	11
LOH12CR1	118426	broad.mit.edu	37	12	12514275	12514275	+	Missense_Mutation	SNP	T	C	C			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr12:12514275T>C	uc001ral.2	+	1	560	c.194T>C	c.(193-195)cTt>cCt	p.L65P	LOH12CR1_uc009zhu.2_Intron	NM_058169	NP_477517	Q969J3	L12R1_HUMAN	Homo sapiens loss of heterozygosity, 12, chromosomal region 1 (LOH12CR1), mRNA.	65										kidney(1)|large_intestine(1)|lung(1)|ovary(1)	4		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.0205)		TTCCAGCCCCTTTTGAAAGGT	0.468													0	1	0	0	0	153	3
MATN3	4148	broad.mit.edu	37	2	20205863	20205863	+	Silent	SNP	C	T	T			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr2:20205863C>T	uc002rdl.3	-	1	495	c.432G>A	c.(430-432)caG>caA	p.Q144Q	MATN3_uc010exu.1_Silent_p.Q144Q	NM_002381	NP_002372	O15232	MATN3_HUMAN	Homo sapiens matrilin 3 (MATN3), mRNA.	144	VWFA.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTTCAGGGACTGCTTATCTG	0.567													0	1	0	0	0	108	3
TNIP1	10318	broad.mit.edu	37	5	150411907	150411907	+	Missense_Mutation	SNP	C	T	T			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr5:150411907C>T	uc003lti.3	-	16	2058	c.1817G>A	c.(1816-1818)cGa>cAa	p.R606Q	TNIP1_uc011dcn.2_Missense_Mutation_p.R124Q|TNIP1_uc010jhq.2_Intron|TNIP1_uc010jho.2_Non-coding_Transcript|TNIP1_uc010jhp.2_Missense_Mutation_p.R489Q|TNIP1_uc010jhl.3_Non-coding_Transcript|TNIP1_uc010jhn.3_Intron|TNIP1_uc010jhm.3_Missense_Mutation_p.R542Q|TNIP1_uc010jhr.2_Missense_Mutation_p.R606Q|TNIP1_uc011dco.2_Missense_Mutation_p.E612K|TNIP1_uc003ltg.3_Missense_Mutation_p.R553Q|TNIP1_uc003ltk.3_Missense_Mutation_p.R606Q|TNIP1_uc003ltj.3_Missense_Mutation_p.R606Q|TNIP1_uc021ygb.1_Missense_Mutation_p.R606Q	NM_006058	NP_006049	Q15025	TNIP1_HUMAN	Homo sapiens TNFAIP3 interacting protein 1 (TNIP1), transcript variant 5, mRNA.	606	Pro-rich.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding	p.R606Q(2)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTTGGATTTCGAACCCCTCC	0.512													0	1	0	0	0	58	3
TUBA3D	113457	broad.mit.edu	37	2	132235871	132235871	+	Silent	SNP	C	T	T			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr2:132235871C>T	uc002tsu.4	+	1	331	c.138C>T	c.(136-138)gaC>gaT	p.D46D		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	Homo sapiens tubulin, alpha 3d (TUBA3D), mRNA.	46					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		GTGGCGGGGACGACTCCTTCA	0.562													0	1	0	0	0	63	48
ZNF211	10520	broad.mit.edu	37	19	58152518	58152518	+	Missense_Mutation	SNP	T	C	C			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr19:58152518T>C	uc002qpr.2	+	5	1159	c.856T>C	c.(856-858)Ttt>Ctt	p.F286L	ZNF211_uc010yhb.1_Missense_Mutation_p.F226L|ZNF211_uc002qpp.2_Missense_Mutation_p.F235L|ZNF211_uc002qpq.2_Missense_Mutation_p.F222L|ZNF211_uc002qpt.2_Missense_Mutation_p.F234L|ZNF211_uc010yhc.1_Missense_Mutation_p.F234L|ZNF211_uc010yhe.1_Missense_Mutation_p.F213L|ZNF211_uc010yhd.1_Missense_Mutation_p.F161L	NM_006385	NP_006376	Q13398	ZN211_HUMAN	Homo sapiens zinc finger protein 211 (ZNF211), transcript variant 1, mRNA.	222						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGCGGTGGCCTTTTACAGTGG	0.468													0	1	0	0	0	97	3
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	rs121913377		TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				0	1	0	0	0	59	43
PCDHB14	56122	broad.mit.edu	37	5	140603736	140603736	+	Missense_Mutation	SNP	C	A	A			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr5:140603736C>A	uc003ljb.3	+	0	659	c.659C>A	c.(658-660)cCg>cAg	p.P220Q		NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	Homo sapiens protocadherin beta 14 (PCDHB14), mRNA.	220	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGATCCCCGCCCAAGTCT	0.478													1	1	1	0	1	122	3
MYO15A	51168	broad.mit.edu	37	17	18029723	18029723	+	Silent	SNP	G	A	A			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr17:18029723G>A	uc021trm.1	+	3	4038	c.3819G>A	c.(3817-3819)ccG>ccA	p.P1273P	MYO15A_uc021trl.1_Silent_p.P1273P	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	Homo sapiens myosin XVA (MYO15A), mRNA.	1273	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	ATP binding|actin binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TCTATGGGCCGGAGCAGGTGC	0.622													0	1	0	0	0	88	3
CYP2A13	1553	broad.mit.edu	37	19	41599590	41599590	+	Missense_Mutation	SNP	T	C	C			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr19:41599590T>C	uc002opt.3	+	5	896	c.887T>C	c.(886-888)cTg>cCg	p.L296P		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	Homo sapiens cytochrome P450, family 2, subfamily A, polypeptide 13 (CYP2A13), mRNA.	296					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	ATGACCACCCTGAACCTCTTC	0.557													0	1	0	0	0	118	3
ANK1	286	broad.mit.edu	37	8	41530310	41530310	+	Missense_Mutation	SNP	G	A	A			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr8:41530310G>A	uc003xok.3	-	37	4742	c.4658C>T	c.(4657-4659)gCg>gTg	p.A1553V	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.3_Intron|ANK1_uc003xoi.3_Missense_Mutation_p.A1553V|ANK1_uc003xoj.3_Missense_Mutation_p.A1553V|ANK1_uc003xol.3_Intron|ANK1_uc003xom.3_Missense_Mutation_p.A1594V	NM_020476	NP_065209	P16157	ANK1_HUMAN	Homo sapiens ankyrin 1, erythrocytic (ANK1), transcript variant 1, mRNA.	1553	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTCCGTGGCCGCCAAGGGGAT	0.622													0	1	0	0	0	59	3
AX746903	0	broad.mit.edu	37	4	120549923	120549923	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr4:120549923delC	uc003idj.1	+	0	979	c.99delC	c.(97-99)ctcfs	p.L33fs	PDE5A_uc003idf.3_5'Flank|PDE5A_uc003idg.3_5'Flank|PDE5A_uc003idh.3_5'UTR					Homo sapiens cDNA FLJ33983 fis, clone DFNES2004684.																		TCGAGACCCTCCCCCTTCGTC	0.711											OREG0016307	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						4	2
WDFY3	23001	broad.mit.edu	37	4	85696234	85696235	+	Frame_Shift_Ins	INS	-	T	T			TCGA-DJ-A3UR-01A-11D-A22D-08	TCGA-DJ-A3UR-10A-01D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6241539c-6660-4bd4-a960-51fcfc3e9259	d924686d-bf80-4471-b658-c02bd6b4e7ba	g.chr4:85696234_85696235insT	uc003hpd.3	-	27	4983_4984	c.4575_4576insA	c.(4573-4578)gaactgfs	p.E1525fs		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	Homo sapiens WD repeat and FYVE domain containing 3 (WDFY3), mRNA.	1525						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCTGTGAGCAGTTCAATAAAGT	0.297																		46	34
