Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	qox	pox_cutoff	pox	oxoGCut	isArtifactMode	t_ref_count	t_alt_count
IGSF1	3547	broad.mit.edu	37	X	130411859	130411859	+	Missense_Mutation	SNP	G	C	C			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chrX:130411859G>C	uc004ewe.4	-	12	2589	c.2306C>G	c.(2305-2307)cCc>cGc	p.P769R	IGSF1_uc004ewd.3_Missense_Mutation_p.P764R|IGSF1_uc022cdv.1_Missense_Mutation_p.P755R|IGSF1_uc004ewf.2_Missense_Mutation_p.P744R	NM_001170961	NP_001164432	Q8N6C5	IGSF1_HUMAN	Homo sapiens immunoglobulin superfamily, member 1 (IGSF1), transcript variant 3, mRNA.	764					regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						CGGCTCACTGGGCTCAGACCA	0.527													0	1.98E-03	0	0	0	112	7
TSHR	7253	broad.mit.edu	37	14	81609760	81609760	+	Missense_Mutation	SNP	T	C	C	rs121908864		TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr14:81609760T>C	uc001xvd.1	+	9	1514	c.1358T>C	c.(1357-1359)aTg>aCg	p.M453T		NM_000369	NP_000360	P16473	TSHR_HUMAN	Homo sapiens thyroid stimulating hormone receptor (TSHR), transcript variant 1, mRNA.	453			M -> T (in HTNA; sporadic; found in toxic thyroid nodules and hyperfunctioning thyroid adenomas).		cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity	p.M453T(62)		breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CGCTTTCTCATGTGCAACCTG	0.527			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						0	3.61E-03	0	0	0	105	52
FAM155A	728215	broad.mit.edu	37	13	108518546	108518546	+	Silent	SNP	G	C	C			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr13:108518546G>C	uc001vql.3	-	0	915	c.399C>G	c.(397-399)ccC>ccG	p.P133P		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	Homo sapiens family with sequence similarity 155, member A (FAM155A), mRNA.	133						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						CTCCCGGGGAGGGGGGCAGGG	0.721													0	9.78E-04	0	0	0	20	8
PLEK	5341	broad.mit.edu	37	2	68608012	68608012	+	Missense_Mutation	SNP	G	A	A	rs144599110		TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr2:68608012G>A	uc002sen.4	+	2	518	c.356G>A	c.(355-357)cGa>cAa	p.R119Q	PLEK_uc010fde.3_Missense_Mutation_p.R119Q	NM_002664	NP_002655	P08567	PLEK_HUMAN	Homo sapiens pleckstrin (PLEK), mRNA.	119					actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGGTCCATTCGACTGCCAGAA	0.458													0	1.98E-03	0	0	0	237	6
OR4C11	219429	broad.mit.edu	37	11	55371142	55371142	+	Silent	SNP	G	A	A	rs146621611	byFrequency	TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr11:55371142G>A	uc010rii.2	-	0	733	c.708C>T	c.(706-708)tcC>tcT	p.S236S		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily C, member 11 (OR4C11), mRNA.	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						ACGTGCAAGCGGAGAGAGCCT	0.413													0	2.48E-04	0	0	0	113	4
TOMM40	10452	broad.mit.edu	37	19	45397111	45397111	+	Silent	SNP	C	T	T			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr19:45397111C>T	uc002paa.4	+	3	706	c.510C>T	c.(508-510)ccC>ccT	p.P170P	TOMM40_uc002ozz.3_Silent_p.P170P|TOMM40_uc002ozx.4_Silent_p.P170P|TOMM40_uc002ozy.4_Silent_p.P170P	NM_001128917	NP_006105	O96008	TOM40_HUMAN	Homo sapiens translocase of outer mitochondrial membrane 40 homolog (yeast) (TOMM40), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	170					protein targeting to mitochondrion	integral to membrane of membrane fraction|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex|pore complex	porin activity|protein transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(1)	5	Lung NSC(12;0.0018)|all_lung(12;0.00481)			OV - Ovarian serous cystadenocarcinoma(262;0.0033)|Epithelial(262;0.176)		AGCTGGGCCCCGGTCTCAGGT	0.647													0	8.87E-03	0	0	0	42	20
PEX1	5189	broad.mit.edu	37	7	92120650	92120650	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr7:92120650A>G	uc003uly.3	-	20	3470	c.3374T>C	c.(3373-3375)aTg>aCg	p.M1125T	PEX1_uc011khr.2_Missense_Mutation_p.M917T|PEX1_uc010ley.3_Missense_Mutation_p.M1068T|PEX1_uc011khs.2_Missense_Mutation_p.M803T	NM_000466	NP_000457	O43933	PEX1_HUMAN	Homo sapiens peroxisomal biogenesis factor 1 (PEX1), mRNA.	1125					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GAGCCGGTACATATTGAATTT	0.408													0	6.02E-04	0	0	0	116	3
IL23R	149233	broad.mit.edu	37	1	67705965	67705965	+	Splice_Site	SNP	G	A	A			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr1:67705965G>A	uc001ddo.3	+	9	1233	c.1148_splice	c.e9+1	p.G383_splice	IL23R_uc009waz.3_Splice_Site_p.G180_splice|IL23R_uc001ddp.2_Intron|IL23R_uc010opi.2_Intron|IL23R_uc010opj.2_Intron|IL23R_uc010opk.2_Intron|IL23R_uc010opl.2_Intron|IL23R_uc010opm.2_Splice_Site|IL23R_uc001ddq.3_Splice_Site_p.G129_splice|IL23R_uc010opn.2_Splice_Site_p.G228_splice|IL23R_uc001ddr.3_Intron|IL23R_uc010opo.1_Splice_Site_p.G242_splice|IL23R_uc010opp.1_Intron|IL23R_uc010opq.1_Splice_Site_p.G212_splice|IL23R_uc010opr.1_Splice_Site|IL23R_uc010oqh.2_Splice_Site_p.G24_splice|IL23R_uc010oqf.2_Splice_Site|IL23R_uc010ops.2_Splice_Site_p.G180_splice|IL23R_uc010opt.2_Splice_Site_p.G24_splice|IL23R_uc010opu.2_Splice_Site_p.G79_splice|IL23R_uc010opv.2_Splice_Site_p.G141_splice|IL23R_uc010opw.2_Intron|IL23R_uc010opx.2_Splice_Site_p.G24_splice|IL23R_uc010opy.2_Splice_Site_p.G150_splice|IL23R_uc010opz.2_Splice_Site_p.G24_splice|IL23R_uc010oqa.2_Splice_Site_p.G24_splice|IL23R_uc010oqb.2_Splice_Site_p.G212_splice|IL23R_uc010oqc.2_Splice_Site_p.G99_splice|IL23R_uc010oqd.2_Intron|IL23R_uc010oqe.2_Intron|IL23R_uc010oqg.2_Intron|IL23R_uc001dds.3_Splice_Site_p.G128_splice|IL23R_uc001ddt.3_Intron	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	Homo sapiens interleukin 23 receptor (IL23R), mRNA.	383					inflammatory response|negative regulation of interleukin-10 production|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						TCCGAACTGGGTAGGTTTTTG	0.323													0	2.48E-04	0	0	0	38	4
FAM207A	85395	broad.mit.edu	37	21	46363721	46363721	+	Silent	SNP	G	A	A			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr21:46363721G>A	uc002zgl.3	+	1	270	c.252G>A	c.(250-252)tcG>tcA	p.S84S	FAM207A_uc002zgm.3_Intron	NM_058190	NP_478070	Q9NSI2	CU070_HUMAN	Homo sapiens family with sequence similarity 207, member A (FAM207A), mRNA.	84																	AGGCAGGCTCGAGTGCACGGA	0.602													0	6.12E-03	0	0	0	53	18
ZNF254	9534	broad.mit.edu	37	19	24310503	24310503	+	Missense_Mutation	SNP	T	G	G			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr19:24310503T>G	uc002nru.3	+	3	1835	c.1701T>G	c.(1699-1701)atT>atG	p.I567M	ZNF254_uc010xrk.2_Missense_Mutation_p.I482M	NM_203282	NP_975011	O75437	ZN254_HUMAN	Homo sapiens zinc finger protein 254 (ZNF254), mRNA.	567					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATAAGAGAATTCATACTGGAG	0.333													0	2.45E-03	0	0	0	33	13
PZP	5858	broad.mit.edu	37	12	9355129	9355129	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr12:9355129C>T	uc001qvl.3	-	2	448	c.419G>A	c.(418-420)gGa>gAa	p.G140E	PZP_uc009zgl.3_5'UTR	NM_002864	NP_002855			Homo sapiens pregnancy-zone protein (PZP), mRNA.											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						ACCTGTCTGTCCTGGTTTATA	0.498													0	1.98E-03	0	0	0	163	7
CXXC4	80319	broad.mit.edu	37	4	105412390	105412390	+	Silent	SNP	C	T	T			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr4:105412390C>T	uc003hxg.3	-	0	78	c.63G>A	c.(61-63)ttG>ttA	p.L21L	AK094561_uc003hxh.1_Intron|CXXC4_uc010ilo.3_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	Homo sapiens CXXC finger protein 4 (CXXC4), mRNA.	21					Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TTGCCATTTGCAACGACGGCT	0.617													0	4.99E-03	0	0	0	306	16
DLC1	10395	broad.mit.edu	37	8	12948874	12948874	+	Missense_Mutation	SNP	T	A	A			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr8:12948874T>A	uc003wwm.2	-	13	4252	c.3808A>T	c.(3808-3810)Act>Tct	p.T1270S	DLC1_uc003wwk.1_Missense_Mutation_p.T833S|DLC1_uc003wwl.1_Missense_Mutation_p.T867S|DLC1_uc011kxx.1_Missense_Mutation_p.T759S	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	Homo sapiens deleted in liver cancer 1 (DLC1), transcript variant 1, mRNA.	1270	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of Rho protein signal transduction|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						AGCCCTTGAGTGGCAGCTAGG	0.423													0	2.10E-03	0	0	0	81	30
ASTN2	23245	broad.mit.edu	37	9	119770423	119770423	+	Silent	SNP	G	A	A			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr9:119770423G>A	uc004bjt.2	-	5	1487	c.1386C>T	c.(1384-1386)ctC>ctT	p.L462L	ASTN2_uc022bml.1_Silent_p.L162L|ASTN2_uc022bmm.1_Silent_p.L162L	NM_014010	NP_054729	O75129	ASTN2_HUMAN	Homo sapiens astrotactin 2 (ASTN2), transcript variant 1, mRNA.	513						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TTTGTCCACAGAGGTCCCTCA	0.582													0	8.29E-03	0	0	0	77	10
ADAMTS18	170692	broad.mit.edu	37	16	77401462	77401462	+	Silent	SNP	G	A	A	rs113746494		TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr16:77401462G>A	uc002ffc.4	-	3	1073	c.654C>T	c.(652-654)ccC>ccT	p.P218P	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_Non-coding_Transcript	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 18 (ADAMTS18), mRNA.	218					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G216_G219del(2)		NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GGCCAGAGCCGGGGTAGCCAC	0.552													0	6.02E-04	0	0	0	107	5
STAT4	6775	broad.mit.edu	37	2	191900911	191900911	+	Missense_Mutation	SNP	T	A	A			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr2:191900911T>A	uc002usm.2	-	16	1864	c.1549A>T	c.(1549-1551)Atg>Ttg	p.M517L	STAT4_uc002usn.2_Missense_Mutation_p.M517L|STAT4_uc010zgk.1_Missense_Mutation_p.M362L|STAT4_uc002uso.2_Missense_Mutation_p.M517L	NM_003151	NP_003142	Q14765	STAT4_HUMAN	Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant 1, mRNA.	517					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TCTGCCAGCATATGGAGTTGA	0.458													0	3.08E-03	0	0	0	81	6
PDZRN4	29951	broad.mit.edu	37	12	41966431	41966431	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr12:41966431T>C	uc010skn.2	+	9	1858	c.1850T>C	c.(1849-1851)aTt>aCt	p.I617T	PDZRN4_uc001rmq.4_Missense_Mutation_p.I359T|PDZRN4_uc009zjz.3_Missense_Mutation_p.I357T|PDZRN4_uc001rmr.3_Missense_Mutation_p.I244T	NM_001164595	NP_001158067	Q6ZMN7	PZRN4_HUMAN	Homo sapiens PDZ domain containing ring finger 4 (PDZRN4), transcript variant 1, mRNA.	617							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCAGACTGCATTGGCAACCCA	0.473													0	1.52E-03	0	0	0	60	20
GGA2	23062	broad.mit.edu	37	16	23498084	23498084	+	Missense_Mutation	SNP	G	T	T			TCGA-EM-A2OW-01A-11D-A202-08	TCGA-EM-A2OW-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17a66d24-de77-4f2a-a8ad-d2c6a69e7671	a4765371-2387-4002-9887-2615e5136f7b	g.chr16:23498084G>T	uc002dlq.3	-	6	690	c.607C>A	c.(607-609)Cac>Aac	p.H203N	GGA2_uc010bxo.2_Non-coding_Transcript	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	Homo sapiens golgi-associated, gamma adaptin ear containing, ARF binding protein 2 (GGA2), mRNA.	203	GAT.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(48;0.0386)		TCCTCGGGGTGGTTGCTCTTT	0.507													4.71E-23	3.61E-03	2.41E-23	0	1	214	68
