Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													9	73					0	0	0.010729	0	0	
PRKAA2	5563	broad.mit.edu	37	1	57140083	57140083	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr1:57140083G>C	uc001cyk.3	+	2	195	c.124G>C	c.(124-126)GTG>CTG	p.V42L		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	42	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						AGGCCATAAAGTGGCAGTTAA	0.303000													15	84					0	0	0.003163	0	0	
AMY2B	280	broad.mit.edu	37	1	104120126	104120126	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr1:104120126G>T	uc001duq.2	+	10	1732	c.1116G>T	c.(1114-1116)TGG>TGT	p.W372C	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.W372C|AMY2B_uc001dus.1_RNA	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	372					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TTAATGATTGGGTTGGGCCAC	0.378000													51	184					1.83081e-24	2.089e-24	0.014410	1	0	
OR10J1	26476	broad.mit.edu	37	1	159410369	159410369	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr1:159410369C>G	uc010piv.1	+	1	821	c.821C>G	c.(820-822)TCA>TGA	p.S274*	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	274	Extracellular (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					AAGCCCAAGTCAGAGAACACC	0.527000													6	90					0	0	0.001168	0	0	
OR2T12	127064	broad.mit.edu	37	1	248458178	248458178	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr1:248458178C>A	uc010pzj.1	-	1	703	c.703G>T	c.(703-705)GCC>TCC	p.A235S		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	235	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GTGGCAAAGGCCTTCTTGCGG	0.517000													15	88					2.23348e-06	2.36643e-06	0.004007	1	0	
PCGF6	84108	broad.mit.edu	37	10	105108736	105108736	+	Missense_Mutation	SNP	C	G	G			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr10:105108736C>G	uc001kwt.2	-	2	449	c.381G>C	c.(379-381)GAG>GAC	p.E127D	PCGF6_uc001kwu.2_Missense_Mutation_p.E127D|PCGF6_uc009xxk.2_RNA|PCGF6_uc009xxl.2_RNA|PCGF6_uc009xxm.2_RNA	NM_001011663	NP_001011663	Q9BYE7	PCGF6_HUMAN	polycomb group ring finger 6 isoform a	127					negative regulation of transcription, DNA-dependent	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)	1		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;2.57e-09)|all cancers(201;7.21e-08)|BRCA - Breast invasive adenocarcinoma(275;0.205)		ATGGGGTCAGCTCAGAGAGAT	0.323000													16	96					0	0	0.004007	0	0	
PDCD11	22984	broad.mit.edu	37	10	105202182	105202182	+	Silent	SNP	C	T	T	rs140340054	by1000genomes	TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr10:105202182C>T	uc001kwy.1	+	32	5007	c.4920C>T	c.(4918-4920)GCC>GCT	p.A1640A		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1640					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		AGGCCCGTGCCGTGGCTGAGA	0.582000													19	55					0	0	0.008871	0	0	
TCERG1L	256536	broad.mit.edu	37	10	132944832	132944832	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr10:132944832G>A	uc001lkp.2	-	7	1212	c.1126C>T	c.(1126-1128)CGC>TGC	p.R376C	TCERG1L_uc009yax.1_RNA	NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	376										large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		AGGTCTCCGCGGTCCTTCAGG	0.547000													21	43					0	0	0.010504	0	0	
PKP3	11187	broad.mit.edu	37	11	404544	404544	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr11:404544G>A	uc001lpc.2	+	13	2445	c.2369G>A	c.(2368-2370)CGG>CAG	p.R790Q		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	790					cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAGGGCTATCGGAAGGAGGAC	0.632000													18	34					0	0	0.008871	0	0	
LOC494141	494141	broad.mit.edu	37	11	18231624	18231624	+	RNA	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr11:18231624G>A	uc009yhh.2	+	2		c.648G>A			LOC494141_uc001mnx.3_RNA|LOC494141_uc009yhi.1_RNA	NR_026541				Homo sapiens cDNA FLJ29025 fis, clone PRS03236.												0						GTGCTTGCAGGGACAACGGAA	0.463000													29	54					0	0	0.006320	0	0	
TRIM48	79097	broad.mit.edu	37	11	55036792	55036792	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr11:55036792G>C	uc010rid.1	+	5	739	c.653G>C	c.(652-654)AGG>ACG	p.R218T		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	202						intracellular	zinc ion binding				0						ACTGGACTGAGGGACAGGCTC	0.498000													5	57					0	0	0.000602	0	0	
NAALADL1	10004	broad.mit.edu	37	11	64822123	64822123	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr11:64822123C>T	uc001ocn.2	-	5	707	c.691G>A	c.(691-693)GAA>AAA	p.E231K	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	231	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						GGAAAGGTTTCGTCGGGTGAG	0.612000											OREG0032001	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	9	26					0	0	0.004482	0	0	
ABCB9	23457	broad.mit.edu	37	12	123430687	123430687	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr12:123430687C>T	uc001udm.3	-	6	1446	c.1136G>A	c.(1135-1137)CGG>CAG	p.R379Q	ABCB9_uc010tai.1_5'Flank|ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Missense_Mutation_p.R379Q|ABCB9_uc010taj.1_Missense_Mutation_p.R379Q|ABCB9_uc001udp.2_Missense_Mutation_p.R379Q|ABCB9_uc001udq.2_Missense_Mutation_p.R161Q|ABCB9_uc001udr.2_Missense_Mutation_p.R379Q	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	379	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		GGCGAAGCTCCGGACAGTCTT	0.587000													16	43					0	0	0.004007	0	0	
LOC284232	284232	broad.mit.edu	37	13	19419995	19419995	+	RNA	SNP	C	G	G	rs78291036	by1000genomes	TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr13:19419995C>G	uc010tcj.1	-	1		c.26115G>C				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						GAACTAAGAACAGTTAGATAA	0.294000													26	56					0	0	0.009535	0	0	
NALCN	259232	broad.mit.edu	37	13	101707679	101707679	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr13:101707679C>T	uc001vox.1	-	44	5374	c.5185G>A	c.(5185-5187)GAC>AAC	p.D1729N		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1729	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCACTTTCGTCGCTCTCCACA	0.473000													9	71					0	0	0.006214	0	0	
TTLL5	23093	broad.mit.edu	37	14	76330134	76330134	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr14:76330134G>T	uc001xrx.2	+	29	3656	c.3451G>T	c.(3451-3453)GCC>TCC	p.A1151S	TTLL5_uc010ask.1_Missense_Mutation_p.A1166S|TTLL5_uc001xrz.2_Missense_Mutation_p.A726S|TTLL5_uc001xsa.2_Missense_Mutation_p.A225S	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1151					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		GCTTCAATTTGCCCTGCAGCA	0.522000													25	73					4.26978e-12	4.63427e-12	0.003330	1	0	
ZFP106	64397	broad.mit.edu	37	15	42743712	42743712	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr15:42743712C>T	uc001zpw.2	-	2	1024	c.689G>A	c.(688-690)CGT>CAT	p.R230H	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Missense_Mutation_p.R13H|ZFP106_uc001zpy.1_Missense_Mutation_p.R253H	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	230						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		ATTTGTACTACGTACACTGGA	0.413000													49	82					0	0	0.014410	0	0	
FAH	2184	broad.mit.edu	37	15	80450463	80450463	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr15:80450463A>G	uc002bfj.2	+	3	225	c.143A>G	c.(142-144)CAC>CGC	p.H48R	FAH_uc002bfk.1_Missense_Mutation_p.H48R|FAH_uc002bfm.1_Missense_Mutation_p.H48R|FAH_uc002bfn.1_5'UTR|FAH_uc010unl.1_Missense_Mutation_p.H48R|FAH_uc002bfl.1_Missense_Mutation_p.H48R	NM_000137	NP_000128	P16930	FAAA_HUMAN	fumarylacetoacetase	48					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding				0						ATCATCAAGCACCTCTTTACT	0.532000									Tyrosinemia_type_1				18	79					0	0	0.008871	0	0	
DVL2	1856	broad.mit.edu	37	17	7133213	7133213	+	Silent	SNP	G	A	A	rs150085753		TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr17:7133213G>A	uc002gez.1	-	5	852	c.570C>T	c.(568-570)GCC>GCT	p.A190A	DVL2_uc010vtr.1_Silent_p.A184A|DVL2_uc010vts.1_Silent_p.A92A|DVL2_uc010clz.1_3'UTR	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	190					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						TCTCGTATCCGGCCAGGTGGC	0.637000													11	64					0	0	0.010729	0	0	
TP53	7157	broad.mit.edu	37	17	7577124	7577124	+	Missense_Mutation	SNP	C	T	T	rs121912657		TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr17:7577124C>T	uc002gim.2	-	8	1008	c.814G>A	c.(814-816)GTG>ATG	p.V272M	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.V272M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V140M|TP53_uc010cng.1_Missense_Mutation_p.V140M|TP53_uc002gii.1_Missense_Mutation_p.V140M|TP53_uc010cnh.1_Missense_Mutation_p.V272M|TP53_uc010cni.1_Missense_Mutation_p.V272M|TP53_uc002gij.2_Missense_Mutation_p.V272M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	272	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in sporadic cancers; somatic mutation).|V -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> A (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V272M(67)|p.V272L(24)|p.V272E(8)|p.0?(7)|p.V272A(7)|p.V272G(4)|p.V272fs*73(4)|p.V272V(3)|p.?(2)|p.F270fs*72(1)|p.E271fs*73(1)|p.V272fs*34(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.G266_E271delGRNSFE(1)|p.V272fs*74(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAACACGCACCTCAAAGCTG	0.527000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	21					0	0	0.004482	0	0	
Unknown	0	broad.mit.edu	37	17	39296167	39296167	+	RNA	SNP	A	G	G			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr17:39296167A>G	uc010cxk.1	-	1		c.537T>C								Homo sapiens partial mRNA for keratin associated protein 4.6 (KRTAP4.6 gene).																		GGCAGGTGGAAATGACACAGG	0.478000													3	3					0	0	0.004672	0	0	
TBC1D3P2	440452	broad.mit.edu	37	17	60342311	60342311	+	RNA	SNP	G	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr17:60342311G>T	uc010woz.1	-	14		c.1818C>A				NR_027486				Homo sapiens cDNA FLJ60189 complete cds, highly similar to TBC1 domain family member 3.												0						AAAACGAGGAGGCGAAGCTTG	0.458000													14	91					2.61193e-14	2.8699e-14	0.009535	1	0	
XAB2	56949	broad.mit.edu	37	19	7684501	7684501	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr19:7684501C>T	uc002mgx.2	-	19	2565	c.2539G>A	c.(2539-2541)GCA>ACA	p.A847T		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	847					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						CCAAACACTGCGGCTGGCACG	0.647000								Direct_reversal_of_damage|NER					9	27					0	0	0.006214	0	0	
FFAR3	2865	broad.mit.edu	37	19	35850476	35850476	+	Silent	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr19:35850476G>A	uc002nzd.2	+	2	759	c.684G>A	c.(682-684)GCG>GCA	p.A228A	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	228	Helical; Name=6; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			GGCTGTTGGCGGCCACGCTGC	0.637000													39	181					0	0	0.006230	0	0	
CYP2A6	1548	broad.mit.edu	37	19	41352841	41352841	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr19:41352841C>T	uc002opl.3	-	5	791	c.770G>A	c.(769-771)CGC>CAC	p.R257H	CYP2A6_uc010ehe.1_Missense_Mutation_p.R53H|CYP2A6_uc010ehf.1_RNA	NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	257					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	ATCCAGCGTGCGCTGGTTGTG	0.572000													4	17					0	0	0.009096	0	0	
ZNF772	400720	broad.mit.edu	37	19	57985198	57985198	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr19:57985198C>T	uc002qot.2	-	5	1175	c.914G>A	c.(913-915)CGC>CAC	p.R305H	ZNF547_uc002qpm.3_Intron|ZNF772_uc010ygy.1_Missense_Mutation_p.R264H|ZNF772_uc010ygz.1_Missense_Mutation_p.R193H|ZNF772_uc010yha.1_Missense_Mutation_p.R251H|ZNF772_uc002qou.2_Missense_Mutation_p.R193H	NM_001024596	NP_001019767	Q68DY9	ZN772_HUMAN	zinc finger protein 772 isoform 1	305	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)|Lung(386;0.174)		TATGGGTTTGCGGCTAAAGGT	0.458000													95	111					0	0	0.014410	0	0	
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	G	G			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358000													3	12					0	0	0.004672	0	0	
CNNM4	26504	broad.mit.edu	37	2	97474375	97474375	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr2:97474375G>A	uc002swx.2	+	6	2124	c.2026G>A	c.(2026-2028)GCA>ACA	p.A676T	CNNM4_uc010yuy.1_Missense_Mutation_p.A163T	NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	676					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3						CGTCTCAACTGCAGCAACCTT	0.607000													16	47					0	0	0.004990	0	0	
TTN	7273	broad.mit.edu	37	2	179641252	179641252	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr2:179641252G>A	uc010zfg.1	-	28	5563	c.5339C>T	c.(5338-5340)ACT>ATT	p.T1780I	TTN_uc010zfh.1_Missense_Mutation_p.T1734I|TTN_uc010zfi.1_Missense_Mutation_p.T1734I|TTN_uc010zfj.1_Missense_Mutation_p.T1734I|TTN_uc002unb.2_Missense_Mutation_p.T1780I|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1780							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATTTGTTAGTGGCTCTGCA	0.433000													17	111					0	0	0.004990	0	0	
CXCR2P1	3580	broad.mit.edu	37	2	218925419	218925419	+	Missense_Mutation	SNP	A	T	T	rs3181379	by1000genomes	TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr2:218925419A>T	uc002vgx.2	-	1	595	c.302T>A	c.(301-303)ATA>AAA	p.I101K	RUFY4_uc002vgw.2_Intron	NR_002712				Homo sapiens interleukin 8 receptor, beta pseudogene, mRNA (cDNA clone IMAGE:5450999), with apparent retained intron.												0						TCTGCCCCATATGGGCCTTAA	0.552000													5	57					0	0	0.000602	0	0	
AP1B1	162	broad.mit.edu	37	22	29747700	29747700	+	Silent	SNP	G	A	A	rs147984110		TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr22:29747700G>A	uc003afj.2	-	8	1237	c.1053C>T	c.(1051-1053)ATC>ATT	p.I351I	AP1B1_uc003afi.2_Silent_p.I351I|AP1B1_uc003afk.2_Silent_p.I351I|AP1B1_uc003afl.2_Silent_p.I351I|AP1B1_uc011ako.1_5'Flank	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	351					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						TGACCTGGGCGATGTTGGCCT	0.572000													13	26					0	0	0.013537	0	0	
PPPDE2	27351	broad.mit.edu	37	22	41997112	41997112	+	Missense_Mutation	SNP	C	T	T	rs144622202		TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr22:41997112C>T	uc003ban.1	-	6	569	c.496G>A	c.(496-498)GGC>AGC	p.G166S	uc003bam.1_5'Flank|PPPDE2_uc011apb.1_RNA	NM_015704	NP_056519	Q6ICB0	PPDE2_HUMAN	PPPDE peptidase domain containing 2	166											0						TAGCTCTGGCCGTTGGGTCTG	0.532000													4	10					0	0	0.009096	0	0	
C22orf40	150383	broad.mit.edu	37	22	46644115	46644115	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr22:46644115G>A	uc003bhe.2	-	2	108	c.67C>T	c.(67-69)CCG>TCG	p.P23S	C22orf40_uc003bhc.2_Missense_Mutation_p.P23S|C22orf40_uc003bhd.2_Missense_Mutation_p.P23S|C22orf40_uc003bhf.2_RNA|uc003bhg.1_5'Flank	NM_207327	NP_997210	Q6NVV7	CV040_HUMAN	hypothetical protein LOC150383	23											0						TAGCTGTACGGAGCTGTCAAG	0.582000													7	24					0	0	0.003080	0	0	
TRAIP	10293	broad.mit.edu	37	3	49867138	49867138	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr3:49867138C>T	uc003cxs.1	-	13	1254	c.1148G>A	c.(1147-1149)GGT>GAT	p.G383D	TRAIP_uc010hla.1_Missense_Mutation_p.G284D	NM_005879	NP_005870	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	383	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGGAAGGCACCAACCAGTTC	0.577000													9	42					0	0	0.004482	0	0	
GPR171	29909	broad.mit.edu	37	3	150916325	150916325	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr3:150916325G>C	uc003eyq.3	-	3	1089	c.849C>G	c.(847-849)ATC>ATG	p.I283M	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_013308	NP_037440	O14626	GP171_HUMAN	G protein-coupled receptor 171	283	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GATAGTACAGGATAGGATCAA	0.438000													11	47					0	0	0.010729	0	0	
MED12L	116931	broad.mit.edu	37	3	151129252	151129252	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr3:151129252C>A	uc003eyp.2	+	39	6030	c.5992C>A	c.(5992-5994)CAG>AAG	p.Q1998K	MED12L_uc011bnz.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1998	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTATGTTCAGCAGCAGGCCTC	0.527000													9	75					0.00621372	0.00650613	0.006214	1	0	
SDHAP2	727956	broad.mit.edu	37	3	195400728	195400728	+	Silent	SNP	A	G	G	rs12107841	by1000genomes	TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr3:195400728A>G	uc003fuw.2	+	9	1218	c.24A>G	c.(22-24)CCA>CCG	p.P8P	SDHAP2_uc011btb.1_Missense_Mutation_p.S156G|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GATTGTGCCCAGCCTGTACGC	0.587000													5	47					0	0	0.000602	0	0	
SDHAP2	727956	broad.mit.edu	37	3	195400795	195400795	+	Missense_Mutation	SNP	C	T	T	rs7615357	by1000genomes	TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr3:195400795C>T	uc003fuw.2	+	9	1285	c.91C>T	c.(91-93)CGC>TGC	p.R31C	SDHAP2_uc011btb.1_Missense_Mutation_p.S178L|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GGGGCAAACTCGCTGTTGGAC	0.592000													5	31					0	0	0.006214	0	0	
SDHAP2	727956	broad.mit.edu	37	3	195400799	195400799	+	Missense_Mutation	SNP	G	A	A	rs7635172	by1000genomes	TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr3:195400799G>A	uc003fuw.2	+	9	1289	c.95G>A	c.(94-96)TGT>TAT	p.C32Y	SDHAP2_uc011btb.1_Silent_p.L179L|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						CAAACTCGCTGTTGGACCTGG	0.597000													5	28					0	0	0.004482	0	0	
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	C	C			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr3:197348739G>C	uc011bug.1	-	4		c.352C>G			LOC220729_uc003fxw.2_RNA|LOC220729_uc003fxy.2_RNA|LOC220729_uc010iao.1_Intron					Homo sapiens cDNA FLJ60865 complete cds, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1).												0						TAATTTTCTAGCTGTGAAAGA	0.398000													9	80					0	0	0.006214	0	0	
FAM175A	84142	broad.mit.edu	37	4	84383771	84383771	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr4:84383771G>A	uc003hou.2	-	9	1146	c.1081C>T	c.(1081-1083)CGG>TGG	p.R361W	MRPS18C_uc011ccu.1_Intron|FAM175A_uc003hot.2_Missense_Mutation_p.R189W|FAM175A_uc003hov.2_Missense_Mutation_p.R252W	NM_139076	NP_620775	Q6UWZ7	F175A_HUMAN	coiled-coil domain containing 98	361					chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1						TCTAACAACCGAGATCTCTTG	0.393000													41	96					0	0	0.006999	0	0	
RXFP3	51289	broad.mit.edu	37	5	33938220	33938220	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr5:33938220C>A	uc003jic.1	+	1	1732	c.1375C>A	c.(1375-1377)CGC>AGC	p.R459S		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	459	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						CAGCGGGGGGCGCTACGACCT	0.597000													9	27					4.68919e-08	5.02817e-08	0.008291	1	0	
REEP2	51308	broad.mit.edu	37	5	137781275	137781275	+	Silent	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr5:137781275G>A	uc003lcz.2	+	7	800	c.678G>A	c.(676-678)GCG>GCA	p.A226A	REEP2_uc003lda.2_Silent_p.A228A|REEP2_uc011cyt.1_Silent_p.A187A	NM_016606	NP_057690	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	226						integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			TCAAAAAAGCGCCCAAAGCTG	0.592000													14	27					0	0	0.002450	0	0	
PCDHB8	56128	broad.mit.edu	37	5	140559227	140559227	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr5:140559227G>A	uc011dai.1	+	1	1798	c.1612G>A	c.(1612-1614)GGC>AGC	p.G538S	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	538	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCAGACCGCGGCTCCCCGGC	0.667000													42	157					0	0	0.011902	0	0	
SYNPO	11346	broad.mit.edu	37	5	150029689	150029689	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr5:150029689C>T	uc003lsn.2	+	3	2958	c.2584C>T	c.(2584-2586)CGC>TGC	p.R862C	SYNPO_uc003lso.3_Missense_Mutation_p.R618C|SYNPO_uc003lsp.2_Missense_Mutation_p.R618C	NM_001109974	NP_001103444	Q8N3V7	SYNPO_HUMAN	synaptopodin isoform B	862	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			large_intestine(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCGGCCCTCGCGCTCCTCACC	0.701000													21	58					0	0	0.003954	0	0	
RPS18	6222	broad.mit.edu	37	6	33244009	33244009	+	Silent	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr6:33244009G>A	uc003odp.1	+	5	393	c.348G>A	c.(346-348)AAG>AAA	p.K116K	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	116					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						GACTGAAGAAGATTCGGGCCC	0.562000													8	58					0	0	0.004482	0	0	
PHIP	55023	broad.mit.edu	37	6	79655835	79655835	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr6:79655835G>C	uc003pir.2	-	38	4739	c.4513C>G	c.(4513-4515)CGA>GGA	p.R1505G	PHIP_uc003piq.2_Missense_Mutation_p.R529G|PHIP_uc011dyp.1_Missense_Mutation_p.R1504G|IRAK1BP1_uc010kbg.1_RNA|PHIP_uc003pio.3_Missense_Mutation_p.R391G	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1505					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		CTTCTGGTTCGAACCACAGAA	0.433000													28	71					0	0	0.006320	0	0	
UTRN	7402	broad.mit.edu	37	6	144858781	144858781	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr6:144858781G>C	uc003qkt.2	+	43	6389	c.6297G>C	c.(6295-6297)TGG>TGC	p.W2099C		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2099					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TTATCTGTTGGTTAACAAAGG	0.348000													11	42					0	0	0.008291	0	0	
PURB	5814	broad.mit.edu	37	7	44924114	44924114	+	Missense_Mutation	SNP	C	G	G			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr7:44924114C>G	uc003tme.2	-	1	847	c.834G>C	c.(832-834)GAG>GAC	p.E278D		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	278					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						TTTCTTTCATCTCATCCGCAT	0.592000													18	155					0	0	0.007413	0	0	
SPDYE7P	441251	broad.mit.edu	37	7	72339497	72339497	+	RNA	SNP	T	C	C	rs390732	by1000genomes	TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr7:72339497T>C	uc010lal.1	-	1		c.159A>G				NR_003666				Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.												0						TCCTCAGATTTGTCCCACCAC	0.582000													5	37					0	0	0.001168	0	0	
SPDYE7P	441251	broad.mit.edu	37	7	72339511	72339511	+	RNA	SNP	A	C	C			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr7:72339511A>C	uc010lal.1	-	1		c.145T>G				NR_003666				Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.												0						CCACCACTCCATCTTCCTTTT	0.582000													4	28					0	0	0.009096	0	0	
Unknown	0	broad.mit.edu	37	7	100552607	100552607	+	RNA	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr7:100552607C>T	uc003uxk.1	+	1		c.1858C>T			uc003uxl.1_Missense_Mutation_p.P353L					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		AGTAGCCTCCCGACCATCCTG	0.577000													17	222					0	0	0.004990	0	0	
NOS3	4846	broad.mit.edu	37	7	150706297	150706297	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr7:150706297C>T	uc003wif.2	+	19	2562	c.2266C>T	c.(2266-2268)CGG>TGG	p.R756W	NOS3_uc011kuy.1_Missense_Mutation_p.R550W	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	756	FAD-binding FR-type.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CGTGCACAGGCGGAAGATGTT	0.627000											OREG0018442	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	39					0	0	0.004482	0	0	
TERF1	7013	broad.mit.edu	37	8	73934526	73934526	+	Missense_Mutation	SNP	A	G	G	rs147608592	byFrequency	TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr8:73934526A>G	uc003xzd.2	+	4	638	c.613A>G	c.(613-615)AAT>GAT	p.N205D	TERF1_uc003xze.2_Missense_Mutation_p.N205D	NM_017489	NP_059523	P54274	TERF1_HUMAN	telomeric repeat binding factor 1 isoform 1	205	TRFH dimerization.				age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			ovary(1)|lung(1)|skin(1)	3	Breast(64;0.218)		Epithelial(68;0.0984)			TGGTGATCCAAATTCTCATAT	0.299000													48	40					0	0	0.014410	0	0	
FAM135B	51059	broad.mit.edu	37	8	139263141	139263141	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr8:139263141G>T	uc003yuy.2	-	6	656	c.485C>A	c.(484-486)TCT>TAT	p.S162Y	FAM135B_uc003yux.2_Missense_Mutation_p.S63Y|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	162										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CGAGATCACAGACAGGTGGAA	0.597000										HNSCC(54;0.14)			29	103					9.80776e-20	1.10492e-19	0.006320	1	0	
PTPRD	5789	broad.mit.edu	37	9	8486014	8486014	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr9:8486014C>T	uc003zkk.2	-	27	3514	c.2803G>A	c.(2803-2805)GTC>ATC	p.V935I	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.V926I|PTPRD_uc003zkm.2_Missense_Mutation_p.V922I|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	935	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GATAACTGGACGGAGGTTGAA	0.483000										TSP Lung(15;0.13)			18	71					0	0	0.007413	0	0	
PLIN2	123	broad.mit.edu	37	9	19120904	19120904	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr9:19120904T>C	uc003zno.2	-	5	748	c.569A>G	c.(568-570)TAC>TGC	p.Y190C	PLIN2_uc011lna.1_Missense_Mutation_p.Y162C|PLIN2_uc011lnb.1_Intron	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	190					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						GAGAGGGAGGTACTGTTCTAC	0.413000													16	83					0	0	0.003163	0	0	
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	G	G			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr9:20414343A>G	uc003zoe.2	-	5	760	c.501T>C	c.(499-501)AGT>AGC	p.S167S	MLLT3_uc011lne.1_Silent_p.S135S|MLLT3_uc011lnf.1_Silent_p.S164S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.V129A	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.139000			T	MLL	ALL								6	57					0	0	0.001168	0	0	
CNTNAP3	79937	broad.mit.edu	37	9	39103860	39103860	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr9:39103860A>T	uc004abi.2	-	16	2656	c.2417T>A	c.(2416-2418)TTC>TAC	p.F806Y	CNTNAP3_uc004abj.2_Missense_Mutation_p.F805Y|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Missense_Mutation_p.F806Y	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	806	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAAGCAGGGAAATGAAGGTA	0.418000													13	28					0	0	0.006122	0	0	
KGFLP2	654466	broad.mit.edu	37	9	41962661	41962661	+	RNA	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr9:41962661G>A	uc004aca.3	-	3		c.848C>T				NR_003670				Homo sapiens cDNA FLJ76381 complete cds.												0						TTTCCCCTCCGTTGTTTGTCC	0.358000													4	39					0	0	0.001984	0	0	
NLGN4X	57502	broad.mit.edu	37	X	5811225	5811225	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chrX:5811225G>A	uc010ndh.2	-	6	2585	c.2084C>T	c.(2083-2085)GCG>GTG	p.A695V	NLGN4X_uc004crp.2_Missense_Mutation_p.A715V|NLGN4X_uc004crq.2_Missense_Mutation_p.A695V|NLGN4X_uc010ndi.2_Missense_Mutation_p.A732V|NLGN4X_uc004crr.2_Missense_Mutation_p.A695V|NLGN4X_uc010ndj.2_Missense_Mutation_p.A695V	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	695	Helical; (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GTAGTACAGCGCCGCAAAAGC	0.507000													15	78					0	0	0.003163	0	0	
CDKN1C	1028	broad.mit.edu	37	11	2906683	2906699	+	Frame_Shift_Del	DEL	CCATCGTGGATGTGCTG	-	-			TCGA-CD-8526-01A-11D-2340-08	TCGA-CD-8526-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	da9892ce-21ca-435e-a73c-38ba1612bebb	bf2b79e2-2d4d-4714-ba49-9da643c998a5	g.chr11:2906683_2906699delCCATCGTGGATGTGCTG	uc001lws.3	-	1	297_313	c.21_37delCAGCACATCCACGATGG	c.(19-39)CGCAGCACATCCACGATGGAGfs	p.R7fs	CDKN1C_uc001lwu.3_Splice_Site|CDKN1C_uc009ydr.2_Splice_Site|CDKN1C_uc001lwt.3_Splice_Site|CDKN1C_uc001lwr.3_Frame_Shift_Del_p.R7fs	NM_000076	NP_000067	P49918	CDN1C_HUMAN	cyclin-dependent kinase inhibitor 1C isoform a	7_13					cell cycle arrest|G1 phase of mitotic cell cycle|negative regulation of epithelial cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding			central_nervous_system(1)	1		all_epithelial(84;0.000187)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|Breast(177;0.00328)|all_neural(188;0.00681)|all_lung(207;0.157)|Lung NSC(207;0.216)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACAAGACGCTCCATCGTGGATGTGCTGCGGAGGGACG	0.539									Beckwith-Wiedemann_syndrome				4	7	---	---	---	---						.
