Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
HSPG2	3339	broad.mit.edu	37	1	22165524	22165524	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:22165524G>A	uc001bfj.2	-	74	9984	c.9944C>T	c.(9943-9945)ACG>ATG	p.T3315M	HSPG2_uc009vqd.2_Missense_Mutation_p.T3316M	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3315	Ig-like C2-type 19.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GAGCTGCACCGTCTCCCCTGC	0.672													4	44					0	0	0.009096	0	0	
EIF3I	8668	broad.mit.edu	37	1	32689716	32689716	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:32689716G>A	uc001bur.3	+	4	711	c.178G>A	c.(178-180)GCT>ACT	p.A60T	C1orf91_uc001buo.3_5'Flank|C1orf91_uc001bup.3_5'Flank|C1orf91_uc009vub.1_5'Flank|C1orf91_uc010oha.1_5'Flank|C1orf91_uc001buq.3_5'Flank|EIF3I_uc009vuc.2_Missense_Mutation_p.A60T|EIF3I_uc001bus.2_Missense_Mutation_p.A12T	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	60	WD 2.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				GTGTGTGGACGCTGACTGTAT	0.537													13	63					0	0	0.119110	0	0	
CSMD2	114784	broad.mit.edu	37	1	34158580	34158580	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:34158580G>T	uc001bxn.1	-	25	3911	c.3882C>A	c.(3880-3882)CAC>CAA	p.H1294Q	CSMD2_uc001bxm.1_Missense_Mutation_p.H1334Q|CSMD2_uc001bxo.1_Missense_Mutation_p.H207Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1294	CUB 8.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGTTGAGATTGTGTTCATAGG	0.552													13	127					0.00010058	0.000104587	0.093190	1	0	
PDE4B	5142	broad.mit.edu	37	1	66827323	66827323	+	Silent	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:66827323A>C	uc001dcn.2	+	10	1058	c.867A>C	c.(865-867)CCA>CCC	p.P289P	PDE4B_uc009war.2_Silent_p.P197P|PDE4B_uc001dco.2_Silent_p.P289P|PDE4B_uc001dcp.2_Silent_p.P274P|PDE4B_uc001dcq.2_Silent_p.P117P|PDE4B_uc009was.2_Silent_p.P56P	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	289					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	TGGAGATCCCATCTCCTACCC	0.393													8	58					0	0	0.038147	0	0	
LRRC7	57554	broad.mit.edu	37	1	70488966	70488966	+	Missense_Mutation	SNP	G	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:70488966G>C	uc001dep.2	+	15	1619	c.1589G>C	c.(1588-1590)TGT>TCT	p.C530S	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	530						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GCATGGGGTTGTATAAGTGGC	0.557													13	84					0	0	0.119110	0	0	
IFI44L	10964	broad.mit.edu	37	1	79093853	79093853	+	Missense_Mutation	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:79093853T>C	uc010oro.1	+	2	432	c.253T>C	c.(253-255)TTT>CTT	p.F85L	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	85						cytoplasm					0						TTCCCTATGGTTTTCACTTCA	0.313													4	31					0	0	0.009096	0	0	
BARHL2	343472	broad.mit.edu	37	1	91180275	91180275	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:91180275G>A	uc001dns.2	-	2	706	c.664C>T	c.(664-666)CGT>TGT	p.R222C		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	222						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GGACTCTCACGGCTACTCGTA	0.542													15	117					0	0	0.132662	0	0	
GFI1	2672	broad.mit.edu	37	1	92946367	92946367	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:92946367C>T	uc001dou.3	-	4	741	c.577G>A	c.(577-579)GCT>ACT	p.A193T	GFI1_uc001dov.3_Missense_Mutation_p.A193T|GFI1_uc001dow.3_Missense_Mutation_p.A193T	NM_001127215	NP_001120687	Q99684	GFI1_HUMAN	growth factor independent 1	193	Ala/Gly-rich.				negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)	1		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		CCAGGGCCAGCGGTGGCACCG	0.652													3	5					0	0	0.115264	0	0	
AMY2B	280	broad.mit.edu	37	1	104122108	104122108	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:104122108G>A	uc001duq.2	+	12	2138	c.1522G>A	c.(1522-1524)GAA>AAA	p.E508K	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.E508K|AMY2B_uc001dus.1_Intron	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	508					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		AATTCATGCTGAATCtaaatt	0.294													12	125					0	0	0.080935	0	0	
CA14	23632	broad.mit.edu	37	1	150230572	150230572	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:150230572G>A	uc001etx.2	+	1	358	c.49G>A	c.(49-51)GAT>AAT	p.D17N	CA14_uc009wln.2_Missense_Mutation_p.D17N	NM_012113	NP_036245	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV precursor	17	Extracellular (Potential).					integral to membrane	carbonate dehydratase activity|metal ion binding			ovary(1)	1	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCTGGCTGCAGATGGGGGTAG	0.532													4	15					0	0	0.009096	0	0	
FLG	2312	broad.mit.edu	37	1	152276266	152276266	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:152276266C>T	uc001ezu.1	-	3	11132	c.11096G>A	c.(11095-11097)CGG>CAG	p.R3699Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3699	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGCTGACCGGCCACGTGT	0.592									Ichthyosis				25	171					0	0	0.074837	0	0	
FLG	2312	broad.mit.edu	37	1	152277297	152277297	+	Silent	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:152277297C>A	uc001ezu.1	-	3	10101	c.10065G>T	c.(10063-10065)GTG>GTT	p.V3355V		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3355	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGCCTGACACTGACTGTG	0.572									Ichthyosis				68	422					3.28615e-30	3.88093e-30	0.139131	1	0	
OR6K3	391114	broad.mit.edu	37	1	158687131	158687131	+	Missense_Mutation	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:158687131A>C	uc010pip.1	-	1	823	c.823T>G	c.(823-825)TTG>GTG	p.L275V		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	275	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CTGAAACGCAAGTACATGAGT	0.463													9	74					0	0	0.069234	0	0	
FCER1A	2205	broad.mit.edu	37	1	159272174	159272174	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:159272174C>T	uc001ftq.2	+	2	119	c.20C>T	c.(19-21)TCC>TTC	p.S7F		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	7						integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	GCCATGGAATCCCCTACTCTA	0.483													10	126					0	0	0.105934	0	0	
C1orf129	80133	broad.mit.edu	37	1	170965696	170965696	+	Missense_Mutation	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:170965696A>C	uc001ghg.2	+	14	1516	c.1386A>C	c.(1384-1386)CAA>CAC	p.Q462H	C1orf129_uc009wvy.2_Missense_Mutation_p.Q269H|C1orf129_uc010plz.1_Missense_Mutation_p.Q462H	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	462							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTGGACTGCAACAGGTGGATA	0.423													11	93					0	0	0.069234	0	0	
DNM3	26052	broad.mit.edu	37	1	171810859	171810859	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:171810859G>A	uc001gie.2	+	1	239	c.63G>A	c.(61-63)TCG>TCA	p.S21S	DNM3_uc001gid.3_Silent_p.S21S|DNM3_uc009wwb.2_Silent_p.S21S|DNM3_uc001gif.2_Silent_p.S21S	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	21					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						ACGCGTTTTCGGCGCTGGGAC	0.687													4	11					0	0	0.009096	0	0	
CFH	3075	broad.mit.edu	37	1	196716354	196716354	+	Missense_Mutation	SNP	C	T	T	rs145347741	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:196716354C>T	uc001gtj.3	+	22	3847	c.3607C>T	c.(3607-3609)CGG>TGG	p.R1203W		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1203	Sushi 20.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TGTGTGTAAACGGGGATATCG	0.383													10	82					0	0	0.093190	0	0	
WNT3A	89780	broad.mit.edu	37	1	228246694	228246694	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:228246694C>T	uc001hrq.1	+	4	665	c.587C>T	c.(586-588)GCC>GTC	p.A196V	WNT3A_uc001hrp.1_Missense_Mutation_p.A196V	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	196					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				CAGGCCATCGCCAGCCACATG	0.667													3	13					0	0	0.115264	0	0	
OR2W5	441932	broad.mit.edu	37	1	247654765	247654765	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:247654765C>T	uc001icz.1	+	1	336	c.336C>T	c.(334-336)TGC>TGT	p.C112C		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCACCGAGTGCGTCCTCCTGG	0.602													10	65					0	0	0.058154	0	0	
OR2T12	127064	broad.mit.edu	37	1	248458139	248458139	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr1:248458139G>T	uc010pzj.1	-	1	742	c.742C>A	c.(742-744)CTC>ATC	p.L248I		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CCATAAAAGAGTCCCACCACA	0.507													14	75					4.3838e-07	4.84819e-07	0.105934	1	0	
DIP2C	22982	broad.mit.edu	37	10	428632	428632	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr10:428632C>T	uc001ifp.2	-	17	2036	c.1946G>A	c.(1945-1947)TGT>TAT	p.C649Y	DIP2C_uc009xhj.1_Missense_Mutation_p.C345Y	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	649						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGCACAAGGACAGATGACCTC	0.488													5	19					0	0	0.021553	0	0	
ITIH5	80760	broad.mit.edu	37	10	7679382	7679382	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr10:7679382G>A	uc001ijq.2	-	5	540	c.461C>T	c.(460-462)GCC>GTC	p.A154V	ITIH5_uc001ijr.1_Missense_Mutation_p.A154V	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	154	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CAGGAAAAAGGCGGCTTTGTC	0.567													10	54					0	0	0.058154	0	0	
MAP3K8	1326	broad.mit.edu	37	10	30749642	30749642	+	Silent	SNP	G	A	A	rs150841663		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr10:30749642G>A	uc001ivi.1	+	9	1977	c.1281G>A	c.(1279-1281)TCG>TCA	p.S427S	MAP3K8_uc009xlf.1_Silent_p.S427S|MAP3K8_uc001ivj.1_Silent_p.S427S	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	427			Missing (in oncogenic form).		cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)				CAGATTCTTCGTGCACAGGAA	0.453													4	36					0	0	0.014758	0	0	
PCDH15	65217	broad.mit.edu	37	10	55955568	55955568	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr10:55955568A>G	uc001jju.1	-	11	1575	c.1180T>C	c.(1180-1182)TAT>CAT	p.Y394H	PCDH15_uc010qhq.1_Missense_Mutation_p.Y399H|PCDH15_uc010qhr.1_Missense_Mutation_p.Y394H|PCDH15_uc010qhs.1_Missense_Mutation_p.Y399H|PCDH15_uc010qht.1_Missense_Mutation_p.Y394H|PCDH15_uc010qhu.1_Missense_Mutation_p.Y394H|PCDH15_uc001jjv.1_Missense_Mutation_p.Y372H|PCDH15_uc010qhv.1_Missense_Mutation_p.Y394H|PCDH15_uc010qhw.1_Missense_Mutation_p.Y357H|PCDH15_uc010qhx.1_Missense_Mutation_p.Y394H|PCDH15_uc010qhy.1_Missense_Mutation_p.Y399H|PCDH15_uc010qhz.1_Missense_Mutation_p.Y394H|PCDH15_uc010qia.1_Missense_Mutation_p.Y372H|PCDH15_uc010qib.1_Missense_Mutation_p.Y372H|PCDH15_uc001jjw.2_Missense_Mutation_p.Y394H	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	394	Cadherin 3.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATTGTAAAATATGGACTTTGA	0.403										HNSCC(58;0.16)			5	45					0	0	0.014758	0	0	
TET1	80312	broad.mit.edu	37	10	70450715	70450715	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr10:70450715C>T	uc001jok.3	+	12	6060	c.5555C>T	c.(5554-5556)CCG>CTG	p.P1852L		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1852					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TCCTGGTCCCCGAAGACTGCT	0.502													11	88					0	0	0.080935	0	0	
CRTAC1	55118	broad.mit.edu	37	10	99770980	99770980	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr10:99770980A>G	uc001kou.1	-	2	495	c.139T>C	c.(139-141)TAT>CAT	p.Y47H	CRTAC1_uc001kov.2_Missense_Mutation_p.Y36H	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	47	FG-GAP 1; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		TTACTGTCATAGTCAGGAGGC	0.562													13	90					0	0	0.105934	0	0	
NOLC1	9221	broad.mit.edu	37	10	103919306	103919306	+	Missense_Mutation	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr10:103919306A>C	uc001kuo.2	+	7	1075	c.840A>C	c.(838-840)AAA>AAC	p.K280N	NOLC1_uc001kup.2_Missense_Mutation_p.K290N|NOLC1_uc001kuq.2_Missense_Mutation_p.K281N|NOLC1_uc009xxb.1_5'UTR|NOLC1_uc001kur.2_5'UTR	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	280	11 X 12 AA approximate repeats of an acidic serine cluster.|Interacts with RPA194.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		AGCAAAAAAAACCCATGAAAA	0.323													6	33					0	0	0.021553	0	0	
C10orf96	374355	broad.mit.edu	37	10	118084562	118084562	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr10:118084562C>T	uc001lck.2	+	2	290	c.39C>T	c.(37-39)ACC>ACT	p.T13T		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	13	Potential.									ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		TCATCTTCACCGAGCATCAGG	0.522													4	32					0	0	0.021553	0	0	
TH	7054	broad.mit.edu	37	11	2185600	2185600	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:2185600G>A	uc001lvq.2	-	14	1469	c.1450C>T	c.(1450-1452)CGC>TGC	p.R484C	TH_uc001lvp.2_Missense_Mutation_p.R480C|TH_uc001lvr.2_Missense_Mutation_p.R453C|TH_uc010qxj.1_Missense_Mutation_p.R457C|TH_uc001lvs.2_Missense_Mutation_p.R359C|TH_uc001lvt.2_Missense_Mutation_p.R363C	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	484					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	GAGAAGGGGCGCTGGATGCGT	0.687													14	37					0	0	0.033300	0	0	
UBQLN3	50613	broad.mit.edu	37	11	5530452	5530452	+	Missense_Mutation	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:5530452T>C	uc001may.1	-	2	423	c.337A>G	c.(337-339)AGT>GGT	p.S113G	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	113										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATCCAGGACTTGGGCCCTGG	0.612													11	36					0	0	0.069234	0	0	
UBQLNL	143630	broad.mit.edu	37	11	5537480	5537480	+	Silent	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:5537480T>C	uc001maz.3	-	1	477	c.192A>G	c.(190-192)CAA>CAG	p.Q64Q	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	64	Ubiquitin-like.									large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CCATCTGGCATTGGAAGTGAG	0.498													6	68					0	0	0.021553	0	0	
ANO3	63982	broad.mit.edu	37	11	26581277	26581277	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:26581277G>A	uc001mqt.3	+	14	1543	c.1398G>A	c.(1396-1398)TTG>TTA	p.L466L	ANO3_uc010rdr.1_Silent_p.L450L|ANO3_uc010rds.1_Silent_p.L305L|ANO3_uc010rdt.1_Silent_p.L320L|MUC15_uc001mqw.2_3'UTR|MUC15_uc001mqx.2_3'UTR|MUC15_uc001mqy.2_3'UTR	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	466	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGACATATTTGTTCGATAATG	0.328													19	132					0	0	0.049695	0	0	
OR4C16	219428	broad.mit.edu	37	11	55340006	55340006	+	Missense_Mutation	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:55340006A>C	uc010rih.1	+	1	403	c.403A>C	c.(403-405)AGC>CGC	p.S135R		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GACCATCATAAGCCAGTGGGT	0.507													24	144					0	0	0.076483	0	0	
OR4P4	81300	broad.mit.edu	37	11	55406228	55406228	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:55406228T>G	uc010rij.1	+	1	395	c.395T>G	c.(394-396)ATT>AGT	p.I132S		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						CACTACACCATTATTATGAGC	0.433													10	73					0	0	0.069234	0	0	
OR5T2	219464	broad.mit.edu	37	11	55999981	55999981	+	Silent	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:55999981A>C	uc010rjc.1	-	1	681	c.681T>G	c.(679-681)TCT>TCG	p.S227S		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	227	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGTCAGAATAAGAAATAGCAA	0.423													28	108					0	0	0.108266	0	0	
MS4A14	84689	broad.mit.edu	37	11	60184378	60184378	+	Missense_Mutation	SNP	C	A	A	rs145801550		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:60184378C>A	uc001npj.2	+	5	2502	c.1937C>A	c.(1936-1938)TCC>TAC	p.S646Y	MS4A14_uc001npi.2_Missense_Mutation_p.S534Y|MS4A14_uc001npn.2_Missense_Mutation_p.S384Y|MS4A14_uc001npk.2_Missense_Mutation_p.S629Y|MS4A14_uc001npl.2_Missense_Mutation_p.S384Y|MS4A14_uc001npm.2_Missense_Mutation_p.S384Y	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	646	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						GATTCAGAATCCCAAATACAG	0.463													11	62					5.50884e-06	5.89265e-06	0.093190	1	0	
DDB1	1642	broad.mit.edu	37	11	61079287	61079287	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:61079287G>A	uc001nrc.3	-	18	2472	c.2246C>T	c.(2245-2247)ACG>ATG	p.T749M	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Missense_Mutation_p.T749M	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	749	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						CAAGGCTGTCGTGCCCCCACT	0.463								NER					20	72					0	0	0.062417	0	0	
PCNXL3	399909	broad.mit.edu	37	11	65387389	65387389	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:65387389T>G	uc001oey.2	+	8	1994	c.1994T>G	c.(1993-1995)TTC>TGC	p.F665C		NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	665						integral to membrane					0						GTGCACTATTTCTACGATGAG	0.617													5	18					0	0	0.021553	0	0	
P2RY6	5031	broad.mit.edu	37	11	73008084	73008084	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:73008084G>A	uc001otm.2	+	4	926	c.521G>A	c.(520-522)CGC>CAC	p.R174H	P2RY6_uc001otn.2_Missense_Mutation_p.R174H|P2RY6_uc001oto.2_Missense_Mutation_p.R174H|P2RY6_uc001otp.2_Missense_Mutation_p.R174H|P2RY6_uc001otq.2_Missense_Mutation_p.R174H|P2RY6_uc001otr.2_Missense_Mutation_p.R174H|P2RY6_uc001ots.2_Missense_Mutation_p.R174H	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	174	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						CAGCGTAACCGCACTGTCTGC	0.637													11	110					0	0	0.080935	0	0	
FUT4	2526	broad.mit.edu	37	11	94278700	94278700	+	Silent	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:94278700C>A	uc001pez.2	+	1	1684	c.1401C>A	c.(1399-1401)TCC>TCA	p.S467S	PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.1_5'Flank	NM_002033	NP_002024	P22083	FUT4_HUMAN	fucosyltransferase 4	467	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			skin(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GTGCCTCCTCCCTGGCCTCGT	0.667													10	53					0.000978159	0.000993383	0.080935	1	0	
PGR	5241	broad.mit.edu	37	11	100933339	100933339	+	Missense_Mutation	SNP	A	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:100933339A>T	uc001pgh.2	-	4	2794	c.2051T>A	c.(2050-2052)ATT>AAT	p.I684N	PGR_uc001pgg.2_Missense_Mutation_p.I65N|PGR_uc001pgi.2_Intron|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	684	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CAGTGGTGGAATCAACTGTAT	0.468													25	194					0	0	0.091800	0	0	
GUCY1A2	2977	broad.mit.edu	37	11	106810753	106810753	+	Silent	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:106810753A>G	uc001pjg.1	-	4	1029	c.639T>C	c.(637-639)TCT>TCC	p.S213S	GUCY1A2_uc010rvo.1_Silent_p.S213S|GUCY1A2_uc009yxn.1_Silent_p.S213S	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	213					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GTTTTCCAAAAGAAGTTCTAA	0.453													14	92					0	0	0.105934	0	0	
IL10RA	3587	broad.mit.edu	37	11	117866365	117866365	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:117866365C>T	uc001prv.2	+	6	827	c.750C>T	c.(748-750)CTC>CTT	p.L250L	IL10RA_uc010rxl.1_Silent_p.L230L|IL10RA_uc010rxm.1_Silent_p.L230L|IL10RA_uc010rxn.1_Silent_p.L101L|IL10RA_uc001prw.2_Silent_p.L101L	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	250	Helical; (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CCGGAGCCCTCGCCTACTGCC	0.587													12	51					0	0	0.093190	0	0	
CXCR5	643	broad.mit.edu	37	11	118765000	118765000	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:118765000G>A	uc001pue.3	+	2	857	c.747G>A	c.(745-747)CAG>CAA	p.Q249Q	CXCR5_uc001puf.2_Silent_p.Q204Q	NM_001716	NP_001707	P32302	CXCR5_HUMAN	Burkitt lymphoma receptor 1 isoform 1	249	Cytoplasmic (Potential).				B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GCCAGGCCCAGCGGCGCCCTC	0.617													5	32					0	0	0.014758	0	0	
TECTA	7007	broad.mit.edu	37	11	120998532	120998532	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:120998532G>A	uc010rzo.1	+	8	1846	c.1846G>A	c.(1846-1848)GAC>AAC	p.D616N		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	616	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CACATGCTCCGACCTGACGGC	0.642													16	65					0	0	0.146539	0	0	
OR8D4	338662	broad.mit.edu	37	11	123778075	123778075	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr11:123778075C>T	uc010saa.1	+	1	937	c.937C>T	c.(937-939)CCA>TCA	p.P313S		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		ATCTTTATCTCCAGGATAAAT	0.269													4	18					0	0	0.009096	0	0	
CACNA1C	775	broad.mit.edu	37	12	2622033	2622033	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:2622033C>T	uc009zdu.1	+	9	1586	c.1273C>T	c.(1273-1275)CGG>TGG	p.R425W	CACNA1C_uc009zdv.1_Missense_Mutation_p.R422W|CACNA1C_uc001qkb.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkc.2_Missense_Mutation_p.R425W|CACNA1C_uc001qke.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkf.2_Missense_Mutation_p.R425W|CACNA1C_uc001qjz.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkd.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkg.2_Missense_Mutation_p.R425W|CACNA1C_uc009zdw.1_Missense_Mutation_p.R425W|CACNA1C_uc001qkh.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkl.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkn.2_Missense_Mutation_p.R425W|CACNA1C_uc001qko.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkp.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkr.2_Missense_Mutation_p.R425W|CACNA1C_uc001qku.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkq.2_Missense_Mutation_p.R425W|CACNA1C_uc001qks.2_Missense_Mutation_p.R425W|CACNA1C_uc001qkt.2_Missense_Mutation_p.R425W|CACNA1C_uc001qka.1_Intron|CACNA1C_uc001qki.1_Missense_Mutation_p.R161W|CACNA1C_uc001qkj.1_Missense_Mutation_p.R161W|CACNA1C_uc001qkk.1_Missense_Mutation_p.R161W|CACNA1C_uc001qkm.1_Missense_Mutation_p.R161W|CACNA1C_uc009zdy.1_Missense_Mutation_p.R50W|CACNA1C_uc001qkv.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	425	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCAGAAGCTGCGGGAGAAGCA	0.552													5	16					0	0	0.021553	0	0	
TAS2R13	50838	broad.mit.edu	37	12	11061719	11061719	+	Missense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:11061719C>A	uc001qzg.1	-	1	443	c.179G>T	c.(178-180)TGG>TTG	p.W60L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron	NM_023920	NP_076409	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	60	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|skin(1)	2						TAATATTTCCCAGATCAGCCC	0.373													10	58					1.58986e-06	1.72898e-06	0.069234	1	0	
PDE3A	5139	broad.mit.edu	37	12	20766614	20766614	+	Missense_Mutation	SNP	G	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:20766614G>C	uc001reh.1	+	3	1271	c.1249G>C	c.(1249-1251)GAC>CAC	p.D417H		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	417					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTCTGAAAAAGACAAGCTTGC	0.428													6	67					0	0	0.029380	0	0	
SLCO1B3	28234	broad.mit.edu	37	12	21011495	21011495	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:21011495T>G	uc001rek.2	+	4	475	c.349T>G	c.(349-351)TTC>GTC	p.F117V	SLCO1B3_uc001rel.2_Missense_Mutation_p.F117V|SLCO1B3_uc010sil.1_Missense_Mutation_p.F117V|LST-3TM12_uc010sim.1_Missense_Mutation_p.F117V	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	117	Helical; Name=3; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					ACCACATTTCTTCATGGGATA	0.338													18	82					0	0	0.049695	0	0	
PYROXD1	79912	broad.mit.edu	37	12	21602575	21602575	+	Missense_Mutation	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:21602575T>C	uc001rew.2	+	4	491	c.364T>C	c.(364-366)TGT>CGT	p.C122R	PYROXD1_uc009ziq.2_5'UTR|PYROXD1_uc009zir.2_Intron	NM_024854	NP_079130	Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase	122							oxidoreductase activity			ovary(1)	1						aaagttgatatgtgaaggaaa	0.259													7	31					0	0	0.029380	0	0	
LRRK2	120892	broad.mit.edu	37	12	40714877	40714877	+	Missense_Mutation	SNP	A	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:40714877A>T	uc001rmg.3	+	35	5178	c.5057A>T	c.(5056-5058)GAG>GTG	p.E1686V	LRRK2_uc009zjw.2_Missense_Mutation_p.E524V|LRRK2_uc001rmi.2_Missense_Mutation_p.E519V	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1686					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CCCCATTGTGAGAACTCTGAA	0.398													11	148					0	0	0.069234	0	0	
NR4A1	3164	broad.mit.edu	37	12	52448549	52448549	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:52448549T>G	uc001rzs.2	+	3	751	c.437T>G	c.(436-438)TTC>TGC	p.F146C	NR4A1_uc010sno.1_Missense_Mutation_p.F159C|NR4A1_uc001rzr.2_Missense_Mutation_p.F146C|NR4A1_uc009zmb.1_Missense_Mutation_p.F146C|NR4A1_uc001rzt.2_Missense_Mutation_p.F146C|NR4A1_uc009zmc.2_5'Flank	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	146					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		ACGCCCAGCTTCCAGCCGCCC	0.687													10	42					0	0	0.080935	0	0	
KRT3	3850	broad.mit.edu	37	12	53186067	53186067	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:53186067C>T	uc001say.2	-	5	1210	c.1144G>A	c.(1144-1146)GCT>ACT	p.A382T		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	382	Rod.|Coil 2.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						CTTCTCTGAGCGATATCCTCA	0.547													7	19					0	0	0.038147	0	0	
OR6C6	283365	broad.mit.edu	37	12	55688654	55688654	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:55688654G>A	uc010sph.1	-	1	363	c.363C>T	c.(361-363)TAC>TAT	p.Y121Y		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						AGATGGCAACGTAGCGGTCAT	0.388													12	46					0	0	0.080935	0	0	
KCNC2	3747	broad.mit.edu	37	12	75601257	75601257	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:75601257G>A	uc001sxg.1	-	2	1051	c.507C>T	c.(505-507)TTC>TTT	p.F169F	KCNC2_uc009zry.2_Silent_p.F169F|KCNC2_uc001sxe.2_Silent_p.F169F|KCNC2_uc001sxf.2_Silent_p.F169F|KCNC2_uc010stw.1_Silent_p.F169F	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	169	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						CGGGGGTCTCGAAGATGTCCA	0.721													5	26					0	0	0.014758	0	0	
ACSS3	79611	broad.mit.edu	37	12	81532956	81532956	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:81532956G>T	uc001szl.1	+	4	783	c.692G>T	c.(691-693)AGG>ATG	p.R231M	ACSS3_uc001szm.1_Missense_Mutation_p.R230M	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	231						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CCTGGAAGGAGGGTAGAGTAC	0.348													12	45					0.00010058	0.000104587	0.093190	1	0	
USP44	84101	broad.mit.edu	37	12	95927656	95927656	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:95927656C>T	uc001teg.2	-	2	521	c.377G>A	c.(376-378)GGT>GAT	p.G126D	USP44_uc001teh.2_Missense_Mutation_p.G126D|USP44_uc009zte.2_Missense_Mutation_p.G123D	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	126					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						AGAATCATCACCTGTACCCAT	0.428													9	73					0	0	0.058154	0	0	
BTBD11	121551	broad.mit.edu	37	12	108013802	108013802	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:108013802G>A	uc001tmk.1	+	11	3013	c.2492G>A	c.(2491-2493)CGG>CAG	p.R831Q	BTBD11_uc009zut.1_Missense_Mutation_p.R712Q|BTBD11_uc001tmj.2_Missense_Mutation_p.R831Q|BTBD11_uc001tml.1_Missense_Mutation_p.R368Q	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	831	ANK 5.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						GAGTCTTTGCGGATCGCCTTC	0.428													7	17					0	0	0.029380	0	0	
ZCCHC8	55596	broad.mit.edu	37	12	122975087	122975087	+	Missense_Mutation	SNP	A	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:122975087A>T	uc001ucn.2	-	4	476	c.345T>A	c.(343-345)TTT>TTA	p.F115L	ZCCHC8_uc009zxp.2_5'UTR|ZCCHC8_uc009zxq.2_5'UTR	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	115						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		AATTTGATACAAATTCCTCTA	0.333													5	12					0	0	0.014758	0	0	
TMEM132B	114795	broad.mit.edu	37	12	126139127	126139127	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr12:126139127C>T	uc001uhe.1	+	9	3116	c.3108C>T	c.(3106-3108)GAC>GAT	p.D1036D	TMEM132B_uc001uhf.1_Silent_p.D548D	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	1036	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TCCCAGAGGACGGCGGCCCAT	0.473													13	60					0	0	0.132662	0	0	
EFHA1	221154	broad.mit.edu	37	13	22095431	22095431	+	Missense_Mutation	SNP	G	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:22095431G>C	uc001uof.2	-	6	572	c.550C>G	c.(550-552)CTG>GTG	p.L184V		NM_152726	NP_689939	Q8IYU8	EFHA1_HUMAN	EF-hand domain family, member A1	184	EF-hand 1.						calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)		TCTGTATCCAGCATTTTAAAA	0.308													7	27					0	0	0.047766	0	0	
TNFRSF19	55504	broad.mit.edu	37	13	24190051	24190051	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:24190051C>T	uc001uov.1	+	4	290	c.226C>T	c.(226-228)CGG>TGG	p.R76W	TNFRSF19_uc001uot.2_Missense_Mutation_p.R76W|TNFRSF19_uc010tcu.1_5'UTR|TNFRSF19_uc001uow.2_Missense_Mutation_p.R76W	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	76	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TGTGACGTGCCGGCTGCACAG	0.537													37	72					0	0	0.086207	0	0	
RXFP2	122042	broad.mit.edu	37	13	32365959	32365959	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:32365959C>T	uc001utt.2	+	15	1233	c.1162C>T	c.(1162-1164)CGA>TGA	p.R388*	RXFP2_uc010aba.2_Nonsense_Mutation_p.R347*	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	388	Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		CAAAAACTTTCGATACTGCTC	0.423													21	64					0	0	0.091800	0	0	
ZC3H13	23091	broad.mit.edu	37	13	46541793	46541793	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:46541793G>A	uc010tfw.1	-	14	4173	c.4167C>T	c.(4165-4167)CGC>CGT	p.R1389R	ZC3H13_uc001vaq.2_5'UTR|ZC3H13_uc001vas.1_Silent_p.R1389R	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1389							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TTGCTTCACAGCGTTTCACAG	0.313													12	104					0	0	0.080935	0	0	
LRCH1	23143	broad.mit.edu	37	13	47224395	47224395	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:47224395G>A	uc001vbj.2	+	2	603	c.367G>A	c.(367-369)GAA>AAA	p.E123K	LRCH1_uc010acp.2_Missense_Mutation_p.E123K|LRCH1_uc001vbk.2_Missense_Mutation_p.E123K|LRCH1_uc001vbl.3_Missense_Mutation_p.E123K	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	123	LRR 2.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TGTATCACTGGAAATTCTTAA	0.348													6	25					0	0	0.029380	0	0	
PCDH17	27253	broad.mit.edu	37	13	58207414	58207414	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:58207414C>T	uc001vhq.1	+	1	1626	c.734C>T	c.(733-735)GCG>GTG	p.A245V	PCDH17_uc010aec.1_Missense_Mutation_p.A245V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	245	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GTCTTCGAGGCGCCATCCTAC	0.602													11	73					0	0	0.080935	0	0	
PCDH17	27253	broad.mit.edu	37	13	58299127	58299127	+	Missense_Mutation	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:58299127A>C	uc001vhq.1	+	4	4071	c.3179A>C	c.(3178-3180)AAA>ACA	p.K1060T	PCDH17_uc010aec.1_Missense_Mutation_p.K1059T|PCDH17_uc001vhr.1_Missense_Mutation_p.K149T	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1060	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGTGAAGCAAAACCAGGAGCC	0.552													12	105					0	0	0.080935	0	0	
PCDH20	64881	broad.mit.edu	37	13	61985660	61985660	+	Missense_Mutation	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:61985660T>C	uc001vid.3	-	2	2936	c.2572A>G	c.(2572-2574)AGA>GGA	p.R858G	PCDH20_uc010thj.1_Missense_Mutation_p.R858G	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	831	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGTTCTTTTCTTAAAAGACTC	0.408													28	47					0	0	0.099896	0	0	
GPC5	2262	broad.mit.edu	37	13	92408651	92408651	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:92408651G>T	uc010tif.1	+	5	1623	c.1257G>T	c.(1255-1257)TGG>TGT	p.W419C		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	419						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TTCCCTGCTGGAATGGAGAAG	0.383													11	103					1.08611e-07	1.21663e-07	0.080935	1	0	
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:115047559C>T	uc001vup.2	+	2	308	c.271C>T	c.(271-273)CTG>TTG	p.L91L	UPF3A_uc010tkn.1_Silent_p.L91L|UPF3A_uc001vuq.2_Silent_p.L91L|UPF3A_uc001vus.2_RNA|UPF3A_uc001vur.2_RNA	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731													5	1					0	0	0.014758	0	0	
OR10G2	26534	broad.mit.edu	37	14	22102698	22102698	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr14:22102698C>T	uc010tmc.1	-	1	301	c.301G>A	c.(301-303)GGC>AGC	p.G101S		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	101	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		GCCACACAGCCACCAAACGGG	0.507													4	40					0	0	0.009096	0	0	
FOXG1	2290	broad.mit.edu	37	14	29237297	29237297	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr14:29237297G>A	uc001wqe.2	+	1	1011	c.812G>A	c.(811-813)GGC>GAC	p.G271D		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	271	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GGCACCACGGGCAAGCTGCGG	0.701													16	37					0	0	0.132662	0	0	
SYT16	83851	broad.mit.edu	37	14	62463155	62463155	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr14:62463155A>G	uc001xfu.1	+	1	615	c.418A>G	c.(418-420)ATT>GTT	p.I140V	SYT16_uc010tsd.1_Missense_Mutation_p.I140V	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	140										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GCTTTCTTCTATTGCGGAGGA	0.473													10	131					0	0	0.069234	0	0	
Unknown	0	broad.mit.edu	37	15	22473099	22473099	+	RNA	SNP	G	A	A	rs28399672	by1000genomes	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:22473099G>A	uc001yuj.1	-	2		c.172C>T								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:H6.																		GGGGGCTGGCGGACCCAGCTC	0.597													21	209					0	0	0.049695	0	0	
NIPA2	81614	broad.mit.edu	37	15	23021278	23021278	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:23021278G>A	uc001yux.2	-	4	672	c.59C>T	c.(58-60)TCC>TTC	p.S20F	NIPA2_uc001yuy.2_Missense_Mutation_p.S20F|NIPA2_uc001yuz.2_Missense_Mutation_p.S20F|NIPA2_uc001yva.2_Missense_Mutation_p.S20F|NIPA2_uc001yvb.2_Missense_Mutation_p.S20F|NIPA2_uc010ayb.2_Missense_Mutation_p.S20F	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	20	Helical; (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		GAAAATGCTGGAGCTCATAGC	0.428													10	73					0	0	0.069234	0	0	
SNRPN	6638	broad.mit.edu	37	15	25222082	25222082	+	Missense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:25222082C>A	uc001ywp.1	+	10	1216	c.326C>A	c.(325-327)GCA>GAA	p.A109E	SNRPN_uc001ywq.1_Missense_Mutation_p.A109E|SNRPN_uc001ywr.1_Missense_Mutation_p.A109E|SNRPN_uc001yws.1_Missense_Mutation_p.A109E|SNRPN_uc001ywt.1_Missense_Mutation_p.A109E|SNRPN_uc001ywv.1_Missense_Mutation_p.A112E|SNRPN_uc001yww.1_Missense_Mutation_p.A109E|SNRPN_uc001ywx.1_Missense_Mutation_p.A109E|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	109					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		GTTGGTAGGGCAGCTGGTAGA	0.562									Prader-Willi_syndrome				15	55					1.5739e-10	1.80963e-10	0.146539	1	0	
GABRG3	2567	broad.mit.edu	37	15	27271960	27271960	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:27271960A>G	uc001zbg.1	+	3	428	c.262A>G	c.(262-264)ATA>GTA	p.I88V	GABRG3_uc001zbf.2_Missense_Mutation_p.I88V	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	88	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TGTGTCATCAATAAACATGGT	0.378													8	8					0	0	0.038147	0	0	
TTBK2	146057	broad.mit.edu	37	15	43067607	43067607	+	Missense_Mutation	SNP	G	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:43067607G>C	uc001zqo.2	-	13	2163	c.1724C>G	c.(1723-1725)ACT>AGT	p.T575S	TTBK2_uc010bcy.2_Missense_Mutation_p.T506S	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	575					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AGGACTTCCAGTTGTTTTATG	0.443													19	52					0	0	0.049695	0	0	
MFAP1	4236	broad.mit.edu	37	15	44105482	44105482	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:44105482G>A	uc001zth.1	-	5	875	c.691C>T	c.(691-693)CGC>TGC	p.R231C		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	231						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		TCAGCCATGCGTTTTGCTTCC	0.483													27	168					0	0	0.125774	0	0	
Unknown	0	broad.mit.edu	37	15	82620400	82620400	+	RNA	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:82620400T>C	uc010bls.1	+	1		c.493T>C								Homo sapiens mRNA for FLJ00317 protein.																		GACCCAAGGGTCAGCCTGAGT	0.672													4	17					0	0	0.009096	0	0	
ANPEP	290	broad.mit.edu	37	15	90349397	90349397	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:90349397G>A	uc002bop.3	-	2	710	c.418C>T	c.(418-420)CGT>TGT	p.R140C		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	140	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CCCACACCACGCAGGACCACC	0.617													25	36					0	0	0.083992	0	0	
SLCO3A1	28232	broad.mit.edu	37	15	92706046	92706046	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:92706046G>A	uc002bqx.2	+	10	2015	c.1814G>A	c.(1813-1815)AGC>AAC	p.S605N	SLCO3A1_uc002bqy.2_Missense_Mutation_p.S605N|SLCO3A1_uc002bqz.1_Missense_Mutation_p.S547N	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	605	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CTGTTCTGGAGCACGTTCTGT	0.562													13	56					0	0	0.093190	0	0	
LASS3	204219	broad.mit.edu	37	15	100942975	100942975	+	Silent	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr15:100942975T>C	uc002bvz.2	-	13	1597	c.1095A>G	c.(1093-1095)TTA>TTG	p.L365L	LASS3_uc002bwa.2_Silent_p.L376L|LASS3_uc002bwb.2_Silent_p.L365L	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	365						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			GGCCGTTCTTTAAACAATCCA	0.433													4	28					0	0	0.009096	0	0	
SEC14L5	9717	broad.mit.edu	37	16	5064923	5064923	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr16:5064923G>A	uc002cye.2	+	16	2223	c.2043G>A	c.(2041-2043)TCG>TCA	p.S681S		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	681	Ser-rich.					integral to membrane|intracellular	transporter activity				0						CCGCCACCTCGTCCTCCTCCT	0.657													6	50					0	0	0.021553	0	0	
A2BP1	54715	broad.mit.edu	37	16	7568266	7568266	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr16:7568266G>A	uc002cys.2	+	5	1133	c.145G>A	c.(145-147)GCG>ACG	p.A49T	A2BP1_uc010buf.1_Missense_Mutation_p.A49T|A2BP1_uc002cyr.1_Missense_Mutation_p.A49T|A2BP1_uc002cyt.2_Missense_Mutation_p.A49T|A2BP1_uc010uxz.1_Missense_Mutation_p.A92T|A2BP1_uc010uya.1_Missense_Mutation_p.A85T|A2BP1_uc002cyv.1_Missense_Mutation_p.A49T|A2BP1_uc010uyb.1_Missense_Mutation_p.A49T|A2BP1_uc002cyw.2_Missense_Mutation_p.A69T|A2BP1_uc002cyy.2_Missense_Mutation_p.A69T|A2BP1_uc002cyx.2_Missense_Mutation_p.A69T|A2BP1_uc010uyc.1_Missense_Mutation_p.A69T	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	49					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TCCCCACCCCGCGCCAGAGTA	0.662													19	115					0	0	0.069288	0	0	
PMM2	5373	broad.mit.edu	37	16	8941586	8941586	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr16:8941586C>T	uc002czf.3	+	8	715	c.645C>T	c.(643-645)GGC>GGT	p.G215G	PMM2_uc010uyf.1_RNA|PMM2_uc010uyg.1_Silent_p.G132G|PMM2_uc010uyh.1_Silent_p.G90G|PMM2_uc010buj.2_RNA|PMM2_uc010uyi.1_Silent_p.G68G|PMM2_uc002czg.1_5'Flank	NM_000303	NP_000294	O15305	PMM2_HUMAN	phosphomannomutase 2	215					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			ovary(1)	1						TCCAGGGTGGCAATGACCATG	0.547													8	45					0	0	0.038147	0	0	
TEPP	374739	broad.mit.edu	37	16	58019442	58019442	+	Missense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr16:58019442C>A	uc002emw.3	+	6	781	c.744C>A	c.(742-744)TTC>TTA	p.F248L	TEPP_uc002emv.3_Missense_Mutation_p.F275L	NM_199456	NP_955535	Q6URK8	TEPP_HUMAN	testis/prostate/placenta-expressed protein	248						extracellular region				kidney(1)|central_nervous_system(1)|skin(1)	3						CCCTGCCTTTCGACTCCCTGT	0.627													4	39					0.00909568	0.00913066	0.009096	1	0	
CENPN	55839	broad.mit.edu	37	16	81061840	81061840	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr16:81061840G>A	uc002ffx.2	+	10	1665	c.875G>A	c.(874-876)CGA>CAA	p.R292Q	CENPN_uc010vnl.1_Missense_Mutation_p.R258Q|CENPN_uc010vnm.1_Missense_Mutation_p.R272Q|CENPN_uc002ffy.3_Missense_Mutation_p.R292Q	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	292					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						GAACCCCTCCGATGCCTAATA	0.393													9	48					0	0	0.047766	0	0	
KLHL36	79786	broad.mit.edu	37	16	84690914	84690914	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr16:84690914C>T	uc002fig.2	+	3	642	c.501C>T	c.(499-501)ATC>ATT	p.I167I	KLHL36_uc010chl.2_Silent_p.I166I	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	167	BACK.									skin(2)	2						ATGCCTTCATCGATGGCTTCA	0.572													7	69					0	0	0.029380	0	0	
TUBB3	10381	broad.mit.edu	37	16	90002028	90002028	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr16:90002028G>A	uc002fph.1	+	4	1234	c.1169G>A	c.(1168-1170)CGG>CAG	p.R390Q	TUBB3_uc002fpf.2_Missense_Mutation_p.R737Q|TUBB3_uc010ciz.1_Missense_Mutation_p.R318Q|TUBB3_uc002fpg.1_Missense_Mutation_p.R244Q|TUBB3_uc002fpi.1_Missense_Mutation_p.R318Q|TUBB3_uc002fpj.1_Missense_Mutation_p.R318Q|TUBB3_uc010cjb.1_Missense_Mutation_p.R244Q|TUBB3_uc002fpk.1_Missense_Mutation_p.R244Q	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	390					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GCCATGTTCCGGCGCAAGGCC	0.627													25	167					0	0	0.099896	0	0	
SERPINF2	5345	broad.mit.edu	37	17	1657612	1657612	+	Silent	SNP	C	T	T	rs147941157		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:1657612C>T	uc002ftk.1	+	10	1337	c.1260C>T	c.(1258-1260)TTC>TTT	p.F420F	SERPINF2_uc010vqr.1_Silent_p.F356F	NM_000934	NP_000925	P08697	A2AP_HUMAN	alpha-2-antiplasmin isoform a precursor	420					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	TCTTCATCTTCGAGGACACCA	0.652													42	95					0	0	0.117977	0	0	
POLR2A	5430	broad.mit.edu	37	17	7416898	7416898	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:7416898C>T	uc002ghf.3	+	29	5549	c.5315C>T	c.(5314-5316)ACT>ATT	p.T1772I		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1772	26.|52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				TATTCACCTACTAGTCCCAAC	0.463													56	299					0	0	0.139131	0	0	
GAS7	8522	broad.mit.edu	37	17	9820567	9820567	+	Missense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:9820567C>A	uc002gmg.1	-	14	1570	c.1409G>T	c.(1408-1410)CGC>CTC	p.R470L	GAS7_uc010vvc.1_Missense_Mutation_p.R284L|GAS7_uc002gmh.1_Missense_Mutation_p.R330L|GAS7_uc010vvd.1_Missense_Mutation_p.R422L|GAS7_uc002gmi.2_Missense_Mutation_p.R406L|GAS7_uc002gmj.1_Missense_Mutation_p.R410L|GAS7_uc010coh.1_Missense_Mutation_p.R410L	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	470					cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						GTCCACAGGGCGGATGTTGCC	0.637			T	MLL	AML*								12	45					3.07112e-06	3.31224e-06	0.080935	1	0	
MYO1D	4642	broad.mit.edu	37	17	30986210	30986210	+	Silent	SNP	G	A	A	rs150683059		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:30986210G>A	uc002hho.1	-	17	2280	c.2268C>T	c.(2266-2268)TAC>TAT	p.Y756Y	MYO1D_uc002hhp.1_Silent_p.Y756Y	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	756						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CGTGCTTCCCGTAGTCTCGCA	0.532											OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	104					0	0	0.069234	0	0	
AMAC1	146861	broad.mit.edu	37	17	33521011	33521011	+	Missense_Mutation	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:33521011A>C	uc002hjd.2	-	1	402	c.316T>G	c.(316-318)TTC>GTC	p.F106V		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	106	DUF6 1.|Helical; (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		AGGGCACAGAAGAAGGCCCGG	0.587													21	163					0	0	0.049695	0	0	
KRT39	390792	broad.mit.edu	37	17	39114929	39114929	+	Missense_Mutation	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:39114929T>C	uc002hvo.1	-	7	1436	c.1400A>G	c.(1399-1401)GAG>GGG	p.E467G	KRT39_uc010wfm.1_Missense_Mutation_p.E200G	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	467	Tail.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				ATCCTTAATCTCCTTGGTGAT	0.498													25	76					0	0	0.083992	0	0	
KRT35	3886	broad.mit.edu	37	17	39635168	39635168	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:39635168C>T	uc002hws.2	-	4	834	c.791G>A	c.(790-792)CGA>CAA	p.R264Q		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	264	Rod.|Coil 2.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				CTCCAGAACTCGGTTCAGGTC	0.552													19	44					0	0	0.038395	0	0	
STAT3	6774	broad.mit.edu	37	17	40476996	40476996	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:40476996C>T	uc002hzl.1	-	16	1689	c.1449G>A	c.(1447-1449)CTG>CTA	p.L483L	STAT3_uc002hzk.1_Silent_p.L483L|STAT3_uc002hzm.1_Silent_p.L483L|STAT3_uc010wgh.1_Silent_p.L385L|STAT3_uc002hzn.1_Silent_p.L483L	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	483					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		GATTGTTGGTCAGCATGTTGT	0.547									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				19	74					0	0	0.055883	0	0	
SLC35B1	10237	broad.mit.edu	37	17	47782507	47782507	+	Silent	SNP	G	A	A	rs150721486	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:47782507G>A	uc002iph.1	-	5	594	c.507C>T	c.(505-507)GTC>GTT	p.V169V	SLC35B1_uc002ipi.1_Silent_p.V102V|SLC35B1_uc002ipj.1_Silent_p.V45V|SLC35B1_uc010wly.1_Silent_p.V169V	NM_005827	NP_005818	P78383	S35B1_HUMAN	solute carrier family 35, member B1	169	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0						CTCCATAGCCGACTGTGTGTT	0.488													22	88					0	0	0.069288	0	0	
ABCA8	10351	broad.mit.edu	37	17	66902186	66902186	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:66902186C>T	uc002jhp.2	-	17	2456	c.2277G>A	c.(2275-2277)TCG>TCA	p.S759S	ABCA8_uc002jhq.2_Silent_p.S799S|ABCA8_uc010wqq.1_Silent_p.S799S|ABCA8_uc010wqr.1_Silent_p.S738S|ABCA8_uc002jhr.2_Silent_p.S799S	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	759						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TTTATTTACCCGATTCATTAA	0.328													14	88					0	0	0.105934	0	0	
FADS6	283985	broad.mit.edu	37	17	72889611	72889611	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:72889611C>T	uc002jmd.1	-	1	95	c.83G>A	c.(82-84)CGG>CAG	p.R28Q		NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	34					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CTCCAGCTCCCGCAGCAGCGC	0.706													4	9					0	0	0.021553	0	0	
TNRC6C	57690	broad.mit.edu	37	17	76089149	76089149	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:76089149G>A	uc002jud.2	+	16	4706	c.4106G>A	c.(4105-4107)CGT>CAT	p.R1369H	TNRC6C_uc002juf.2_Missense_Mutation_p.R1366H	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1369					gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGCTGGTCACGTGCCAAATCT	0.502													9	39					0	0	0.047766	0	0	
BAHCC1	57597	broad.mit.edu	37	17	79410252	79410252	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr17:79410252C>T	uc002kaf.2	+	3	1877	c.1877C>T	c.(1876-1878)CCG>CTG	p.P626L	BAHCC1_uc002kae.2_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	626							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CTGCCTGCGCCGCCGGACGAG	0.662													5	34					0	0	0.014758	0	0	
LAMA1	284217	broad.mit.edu	37	18	7036008	7036008	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr18:7036008G>A	uc002knm.2	-	13	1911	c.1817C>T	c.(1816-1818)TCG>TTG	p.S606L	LAMA1_uc010wzj.1_Missense_Mutation_p.S82L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	606	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCAGCATGCGACATGAGGTT	0.433													10	21					0	0	0.080935	0	0	
CDH2	1000	broad.mit.edu	37	18	25727656	25727656	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr18:25727656T>G	uc002kwg.2	-	2	612	c.153A>C	c.(151-153)GAA>GAC	p.E51D		NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	51					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GAGGCTGTCCTTCATGCACAT	0.398													11	31					0	0	0.080935	0	0	
SMAD2	4087	broad.mit.edu	37	18	45395639	45395639	+	Nonsense_Mutation	SNP	G	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr18:45395639G>C	uc002lcy.2	-	4	743	c.495C>G	c.(493-495)TAC>TAG	p.Y165*	SMAD2_uc002lcz.2_Nonsense_Mutation_p.Y165*|SMAD2_uc010xdc.1_Nonsense_Mutation_p.Y135*|SMAD2_uc010xdd.1_Nonsense_Mutation_p.Y135*	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	165	MH1.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						TCTGATAGTGGTAAGGGTTTA	0.368													4	14					0	0	0.009096	0	0	
ZNF516	9658	broad.mit.edu	37	18	74154275	74154275	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr18:74154275C>T	uc010dqx.1	-	2	971	c.736G>A	c.(736-738)GGG>AGG	p.G246R	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGGAACTCCCCGGGGCTCAGC	0.687													3	10					0	0	0.115264	0	0	
ZNF236	7776	broad.mit.edu	37	18	74622027	74622027	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr18:74622027G>T	uc002lmi.2	+	15	2747	c.2549G>T	c.(2548-2550)GGG>GTG	p.G850V	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	850					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TCCTCAGATGGGTTTGTGGCT	0.498													10	49					2.80697e-09	3.19922e-09	0.080935	1	0	
EMR1	2015	broad.mit.edu	37	19	6897451	6897451	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:6897451G>A	uc002mfw.2	+	5	445	c.407G>A	c.(406-408)TGC>TAC	p.C136Y	EMR1_uc010dvc.2_Missense_Mutation_p.C136Y|EMR1_uc010dvb.2_Missense_Mutation_p.C84Y|EMR1_uc010xji.1_Intron|EMR1_uc010xjj.1_Missense_Mutation_p.C136Y	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	136	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					ATCAATGAGTGCCTCACCAGC	0.478													8	53					0	0	0.038147	0	0	
MAN2B1	4125	broad.mit.edu	37	19	12760024	12760024	+	Missense_Mutation	SNP	T	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:12760024T>A	uc002mub.2	-	20	2438	c.2362A>T	c.(2362-2364)AAC>TAC	p.N788Y	MAN2B1_uc010dyv.1_Missense_Mutation_p.N787Y	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	788					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						AGCTGCATGTTTCCATCCTGG	0.582													8	35					0	0	0.058154	0	0	
RAD23A	5886	broad.mit.edu	37	19	13059627	13059627	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:13059627G>A	uc002mvw.1	+	5	709	c.600G>A	c.(598-600)ACG>ACA	p.T200T	RAD23A_uc002mvx.1_Silent_p.T200T|RAD23A_uc002mvz.1_Silent_p.T200T|RAD23A_uc002mwa.1_Silent_p.T200T|RAD23A_uc002mvy.1_Silent_p.T35T|RAD23A_uc010xmw.1_Silent_p.T35T	NM_005053	NP_005044	P54725	RD23A_HUMAN	UV excision repair protein RAD23 homolog A	200	UBA 1.				interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)	1						ATCTGCTCACGGTGAGGTGGG	0.647								NER					40	76					0	0	0.104719	0	0	
OR10H2	26538	broad.mit.edu	37	19	15839276	15839276	+	Silent	SNP	C	T	T	rs147373947	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:15839276C>T	uc002nbm.2	+	1	443	c.423C>T	c.(421-423)TGC>TGT	p.C141C		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CACGGGGCTGCGCCTGCCTGG	0.632													21	38					0	0	0.055883	0	0	
ZNF253	56242	broad.mit.edu	37	19	20003046	20003046	+	Silent	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:20003046T>C	uc002noj.2	+	4	1082	c.990T>C	c.(988-990)CAT>CAC	p.H330H	ZNF253_uc002nok.2_Silent_p.H254H|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	330	C2H2-type 6.			Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTACTATACATAAGAGAATTC	0.388													8	34					0	0	0.038147	0	0	
ZNF737	100129842	broad.mit.edu	37	19	20728762	20728762	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:20728762G>A	uc002npa.2	-	4	427	c.247C>T	c.(247-249)CGA>TGA	p.R83*		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	83					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CAAAGATCTCGGGCAAAATGA	0.328													7	42					0	0	0.038147	0	0	
ZNF431	170959	broad.mit.edu	37	19	21365865	21365865	+	Silent	SNP	T	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:21365865T>A	uc002npp.2	+	5	906	c.759T>A	c.(757-759)ATT>ATA	p.I253I	ZNF431_uc010ecq.2_Silent_p.I162I|ZNF431_uc010ecr.2_Silent_p.I254I	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	253	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						ACAAGAGAATTCATACTGGAG	0.363													6	59					0	0	0.021553	0	0	
ZNF99	7652	broad.mit.edu	37	19	22940707	22940707	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:22940707T>G	uc010xrh.1	-	5	1731	c.1731A>C	c.(1729-1731)AAA>AAC	p.K577N		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TATGAATTACTTTATGTCTAG	0.363													12	37					0	0	0.080935	0	0	
TSHZ3	57616	broad.mit.edu	37	19	31768677	31768677	+	Silent	SNP	C	T	T	rs151270303		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:31768677C>T	uc002nsy.3	-	2	2087	c.2022G>A	c.(2020-2022)CCG>CCA	p.P674P		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	674					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					ACCCATCCCGCGGGGGGCTGG	0.657													10	44					0	0	0.058154	0	0	
ACTN4	81	broad.mit.edu	37	19	39215080	39215080	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:39215080C>T	uc002oja.1	+	16	1944	c.1885C>T	c.(1885-1887)CTG>TTG	p.L629L	ACTN4_uc002ojb.1_5'Flank	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	629	Spectrin 3.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGTGCAGCAGCTGGTGCCAAA	0.701													6	37					0	0	0.021553	0	0	
RTN2	6253	broad.mit.edu	37	19	45998025	45998025	+	Silent	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:45998025G>T	uc002pcb.2	-	3	546	c.318C>A	c.(316-318)GGC>GGA	p.G106G	RTN2_uc002pcc.2_Silent_p.G106G|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	106						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		CCAAGCTGTCGCCCAGGCTGG	0.711													10	68					6.40141e-05	6.73697e-05	0.080935	1	0	
ZC3H4	23211	broad.mit.edu	37	19	47588354	47588354	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:47588354C>T	uc002pga.3	-	8	1104	c.1066G>A	c.(1066-1068)GGA>AGA	p.G356R	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	356	Gly-rich.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TCGTTCATTCCGCCCTTGTTC	0.587													46	163					0	0	0.139131	0	0	
KLK13	26085	broad.mit.edu	37	19	51559890	51559890	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:51559890C>T	uc002pvn.2	-	5	831	c.788G>A	c.(787-789)CGA>CAA	p.R263Q	KLK13_uc002pvl.2_RNA|KLK13_uc002pvm.2_RNA|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Missense_Mutation_p.R190Q|KLK13_uc002pvq.2_RNA|KLK13_uc010eoo.2_Missense_Mutation_p.R111Q	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor	263	Peptidase S1.				proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		TTCATATTTTCGGATTGTTTC	0.512													56	183					0	0	0.139131	0	0	
ZNF347	84671	broad.mit.edu	37	19	53645344	53645344	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:53645344A>G	uc002qbb.1	-	5	806	c.737T>C	c.(736-738)TTA>TCA	p.L246S	ZNF347_uc010eql.1_Missense_Mutation_p.L247S|ZNF347_uc002qbc.1_Missense_Mutation_p.L247S	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TGTGAGTAATAAAGAAGAGAT	0.358													24	102					0	0	0.069288	0	0	
LENG9	94059	broad.mit.edu	37	19	54974143	54974143	+	Missense_Mutation	SNP	C	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:54974143C>G	uc010yez.1	-	1	752	c.633G>C	c.(631-633)AAG>AAC	p.K211N		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	211					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		TGCTCCCTCGCTTGGGGGCAG	0.716													4	32					0	0	0.009096	0	0	
NLRP11	204801	broad.mit.edu	37	19	56307512	56307512	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:56307512C>T	uc010ygf.1	-	8	2987	c.2276G>A	c.(2275-2277)AGG>AAG	p.R759K	NLRP11_uc002qlz.2_Missense_Mutation_p.R606K|NLRP11_uc002qmb.2_Missense_Mutation_p.R660K|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	759	LRR 3.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CCCGTCGCTCCTCAGCGGATT	0.493													52	162					0	0	0.139131	0	0	
ZNF583	147949	broad.mit.edu	37	19	56935080	56935080	+	Silent	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:56935080T>C	uc010ygl.1	+	5	1218	c.1053T>C	c.(1051-1053)CCT>CCC	p.P351P	ZNF583_uc002qnc.2_Silent_p.P351P|ZNF583_uc010ygm.1_Silent_p.P351P	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	351				P -> R (in Ref. 3; AAB81088).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		GAGAGAAACCTTATGTGTGTA	0.403													26	71					0	0	0.099896	0	0	
PEG3	5178	broad.mit.edu	37	19	57335747	57335747	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:57335747G>T	uc002qnu.2	-	1	628	c.277C>A	c.(277-279)CAG>AAG	p.Q93K	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_5'UTR|ZIM2_uc002qnq.2_5'UTR|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_5'UTR|PEG3_uc002qnt.2_Missense_Mutation_p.Q93K|PEG3_uc002qnv.2_Missense_Mutation_p.Q93K|PEG3_uc002qnw.2_5'UTR|PEG3_uc002qnx.2_5'UTR|PEG3_uc010etr.2_Missense_Mutation_p.Q93K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	93	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTCAGGTACTGCTCAAGGACC	0.542													33	85					9.65021e-13	1.11942e-12	0.045705	1	0	
ZNF134	7693	broad.mit.edu	37	19	58132192	58132192	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr19:58132192C>T	uc002qpn.2	+	3	804	c.705C>T	c.(703-705)AGC>AGT	p.S235S	ZNF134_uc002qpo.2_Silent_p.S62S|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	235	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		ATGAATGCAGCGAATGTGGAA	0.443													13	40					0	0	0.105934	0	0	
PXDN	7837	broad.mit.edu	37	2	1643130	1643130	+	Missense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:1643130C>A	uc002qxa.2	-	20	4081	c.4017G>T	c.(4015-4017)GAG>GAT	p.E1339D		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1339					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GGTAGCTGAACTCAAGAGACC	0.507													7	24					0.000274275	0.000284071	0.047766	1	0	
BIRC6	57448	broad.mit.edu	37	2	32707635	32707635	+	Missense_Mutation	SNP	G	A	A	rs144411884		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:32707635G>A	uc010ezu.2	+	39	7815	c.7681G>A	c.(7681-7683)GTT>ATT	p.V2561I		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2561					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GACAGTTAGCGTTTCAGTCTC	0.393													8	60					0	0	0.047766	0	0	
RASGRP3	25780	broad.mit.edu	37	2	33752219	33752220	+	Missense_Mutation	DNP	AC	CA	CA			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:33752219_33752220AC>CA	uc002rox.2	+	11	1450_1451	c.823_824AC>CA	c.(823-825)ACA>CAA	p.T275Q	RASGRP3_uc010ync.1_Missense_Mutation_p.T275Q|RASGRP3_uc002roy.2_Missense_Mutation_p.T275Q	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	275	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					GAATGAAATGACAGAGTTGGTC	0.485													10	28					0	0	0.115264	0	0	
NRXN1	9378	broad.mit.edu	37	2	50780014	50780014	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:50780014G>T	uc010fbq.2	-	9	3067	c.1590C>A	c.(1588-1590)TTC>TTA	p.F530L	NRXN1_uc002rxb.3_Missense_Mutation_p.F162L|NRXN1_uc002rxe.3_Missense_Mutation_p.F490L|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCAAAGAGATGAAAGACTCTG	0.418													15	67					3.35478e-16	3.90891e-16	0.132662	1	0	
CCDC85A	114800	broad.mit.edu	37	2	56570051	56570051	+	Silent	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:56570051A>G	uc002rzn.2	+	3	1780	c.1278A>G	c.(1276-1278)AGA>AGG	p.R426R		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	426	Potential.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGGAGGCAAGAGTAAGACAGC	0.418													3	8					0	0	0.014758	0	0	
EIF2AK3	9451	broad.mit.edu	37	2	88890523	88890523	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:88890523A>G	uc002stc.3	-	5	1017	c.815T>C	c.(814-816)ATG>ACG	p.M272T		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	272	Lumenal (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						TCTCGTTTCCATGTCTGGAAT	0.368													15	57					0	0	0.146539	0	0	
MGAT4A	11320	broad.mit.edu	37	2	99260500	99260500	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:99260500C>T	uc002sze.2	-	10	1220	c.906G>A	c.(904-906)GCG>GCA	p.A302A	C2orf64_uc002sza.2_RNA|MGAT4A_uc010yvm.1_Silent_p.A174A|MGAT4A_uc010fil.2_Silent_p.A56A	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	302	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						TAAGATCCGGCGCTTGAAACA	0.408													6	63					0	0	0.029380	0	0	
LRP1B	53353	broad.mit.edu	37	2	140990805	140990805	+	Nonsense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:140990805C>A	uc002tvj.1	-	91	14722	c.13750G>T	c.(13750-13752)GAA>TAA	p.E4584*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4584	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGAAGCAGTTCTTTCCTTTCA	0.333										TSP Lung(27;0.18)			13	38					5.50884e-06	5.89265e-06	0.093190	1	0	
LRP1B	53353	broad.mit.edu	37	2	141215210	141215210	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:141215210T>G	uc002tvj.1	-	61	10608	c.9636A>C	c.(9634-9636)CAA>CAC	p.Q3212H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3212	Extracellular (Potential).|LDL-receptor class B 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGGAATATCTTGATTAGGGA	0.418										TSP Lung(27;0.18)			27	82					0	0	0.134883	0	0	
LRP1B	53353	broad.mit.edu	37	2	141751631	141751631	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:141751631T>G	uc002tvj.1	-	16	3549	c.2577A>C	c.(2575-2577)CAA>CAC	p.Q859H	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	859	Extracellular (Potential).|LDL-receptor class A 3.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCACCGAGCTTGGATACAGT	0.423										TSP Lung(27;0.18)			19	78					0	0	0.055883	0	0	
LRP2	4036	broad.mit.edu	37	2	170063434	170063434	+	Nonsense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:170063434C>A	uc002ues.2	-	39	7009	c.6796G>T	c.(6796-6798)GAG>TAG	p.E2266*		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2266	LDL-receptor class B 23.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCAGAGTTCTCTCCATTGATA	0.403													16	117					1.3612e-06	1.4865e-06	0.132662	1	0	
TTN	7273	broad.mit.edu	37	2	179439346	179439346	+	Missense_Mutation	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:179439346A>C	uc010zfg.1	-	275	64033	c.63809T>G	c.(63808-63810)GTT>GGT	p.V21270G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V14965G|TTN_uc010zfi.1_Missense_Mutation_p.V14898G|TTN_uc010zfj.1_Missense_Mutation_p.V14773G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22197							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCCTTGGTAACTGCAGTTAC	0.433													7	59					0	0	0.029380	0	0	
TTN	7273	broad.mit.edu	37	2	179669304	179669304	+	Silent	SNP	G	A	A	rs143623862		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:179669304G>A	uc002und.2	-	2	291	c.66C>T	c.(64-66)ACC>ACT	p.T22T	TTN_uc010zfg.1_Silent_p.T22T|TTN_uc010zfh.1_Silent_p.T22T|TTN_uc010zfi.1_Silent_p.T22T|TTN_uc010zfj.1_Silent_p.T22T|TTN_uc002unb.2_Silent_p.T22T			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	22							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAAGGTTGCGGTACTACCCT	0.438													6	41					0	0	0.029380	0	0	
ZNF804A	91752	broad.mit.edu	37	2	185802547	185802547	+	Silent	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:185802547T>G	uc002uph.2	+	4	3018	c.2424T>G	c.(2422-2424)CCT>CCG	p.P808P		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	808						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CCTGCAAGCCTAAAAAGAAAC	0.383													5	49					0	0	0.021553	0	0	
SLC11A1	6556	broad.mit.edu	37	2	219258851	219258851	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:219258851C>T	uc002vhv.2	+	13	1663	c.1323C>T	c.(1321-1323)TTC>TTT	p.F441F	SLC11A1_uc010zkc.1_Silent_p.F374F|SLC11A1_uc002vhu.1_Silent_p.F236F|SLC11A1_uc002vhw.2_Silent_p.F323F|SLC11A1_uc010fvr.2_Silent_p.F236F	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	441	Helical; (Potential).			F -> V (in Ref. 5; CAA57541).	activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCTCCCGTTCGCCGTGCTGC	0.537													6	56					0	0	0.021553	0	0	
DGKD	8527	broad.mit.edu	37	2	234299087	234299087	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:234299087C>T	uc002vui.1	+	3	318	c.306C>T	c.(304-306)AGC>AGT	p.S102S	DGKD_uc002vuj.1_Silent_p.S58S	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	102	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CAGATGCCAGCGTAGCTGAAT	0.423													7	52					0	0	0.029380	0	0	
HDLBP	3069	broad.mit.edu	37	2	242181952	242181952	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:242181952C>T	uc002waz.2	-	17	2320	c.2092G>A	c.(2092-2094)GAC>AAC	p.D698N	HDLBP_uc002wba.2_Missense_Mutation_p.D698N|HDLBP_uc002wbb.2_Missense_Mutation_p.D650N	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	698	KH 8.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		ACAACGGTGTCGCTTCCTGAA	0.602													4	42					0	0	0.009096	0	0	
D2HGDH	728294	broad.mit.edu	37	2	242695360	242695360	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr2:242695360G>A	uc002wce.1	+	9	1410	c.1237G>A	c.(1237-1239)GAC>AAC	p.D413N	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Missense_Mutation_p.D279N|D2HGDH_uc002wcg.1_RNA|D2HGDH_uc002wch.2_RNA|D2HGDH_uc002wci.2_Missense_Mutation_p.D112N	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	413					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GCGGCTCTACGACATCGTGAC	0.567													9	79					0	0	0.047766	0	0	
VPS16	64601	broad.mit.edu	37	20	2847197	2847197	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr20:2847197A>G	uc002whe.2	+	24	2545	c.2497A>G	c.(2497-2499)AGG>GGG	p.R833G	VPS16_uc002whh.2_Intron|PTPRA_uc002whj.2_Intron|VPS16_uc002whf.2_Missense_Mutation_p.R689G|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Missense_Mutation_p.R519G|VPS16_uc002whi.2_Missense_Mutation_p.R317G	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	833					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						TCAACGGGCCAGGGCACAAGC	0.582													28	92					0	0	0.134883	0	0	
PLCB1	23236	broad.mit.edu	37	20	8665634	8665634	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr20:8665634C>T	uc002wnb.2	+	10	921	c.918C>T	c.(916-918)GTC>GTT	p.V306V	PLCB1_uc010zrb.1_Silent_p.V205V|PLCB1_uc002wna.2_Silent_p.V306V|PLCB1_uc002wnc.1_Silent_p.V205V	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	306					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AAAACGGAGTCGTTTCACCTG	0.413													16	134					0	0	0.132662	0	0	
SEMG1	6406	broad.mit.edu	37	20	43837052	43837052	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr20:43837052C>T	uc002xni.2	+	2	1171	c.1114C>T	c.(1114-1116)CGC>TGC	p.R372C	SEMG1_uc002xnj.2_Missense_Mutation_p.R312C|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	372	58 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				TGTATCCCAACGCAGTATTTA	0.418													19	53					0	0	0.038395	0	0	
TFAP2C	7022	broad.mit.edu	37	20	55206365	55206365	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr20:55206365C>T	uc002xya.2	+	2	396	c.153C>T	c.(151-153)GTC>GTT	p.V51V	TFAP2C_uc010zzi.1_5'UTR	NM_003222	NP_003213	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma	51	Gln/Pro-rich (transactivation domain).				cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Colorectal(105;0.229)			ACACTGGAGTCGCCGAATATC	0.687													9	67					0	0	0.069234	0	0	
DSCR9	257203	broad.mit.edu	37	21	38593774	38593774	+	RNA	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr21:38593774A>C	uc010gnk.2	+	1		c.886A>C								Homo sapiens mRNA, complete cds.												0						CAGCGTTAGCATGTGGAGGCA	0.522													30	79					0	0	0.054565	0	0	
RIPK4	54101	broad.mit.edu	37	21	43161417	43161417	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr21:43161417C>T	uc002yzn.1	-	8	1984	c.1936G>A	c.(1936-1938)GAG>AAG	p.E646K		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	646						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						TGCCCCGTCTCCGCGGCCACG	0.692													17	51					0	0	0.043863	0	0	
LARGE	9215	broad.mit.edu	37	22	34046630	34046630	+	Missense_Mutation	SNP	G	A	A	rs143437080	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr22:34046630G>A	uc003and.3	-	4	710	c.131C>T	c.(130-132)CCG>CTG	p.P44L	LARGE_uc003ane.3_Missense_Mutation_p.P44L|LARGE_uc010gwp.2_Missense_Mutation_p.P44L|LARGE_uc011ame.1_5'UTR|LARGE_uc011amf.1_Missense_Mutation_p.P44L	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	44	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				GGACTCCAGCGGTGACAGAGA	0.632													4	45					0	0	0.009096	0	0	
TEF	7008	broad.mit.edu	37	22	41791804	41791804	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr22:41791804G>A	uc003azy.2	+	4	838	c.752G>A	c.(751-753)CGG>CAG	p.R251Q	TEF_uc003azx.2_Missense_Mutation_p.R221Q|TEF_uc011apa.1_Missense_Mutation_p.R256Q	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	251	Basic motif.				rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAACGGTCACGGGATGCCCGG	0.582													24	49					0	0	0.083992	0	0	
PKDREJ	10343	broad.mit.edu	37	22	46653338	46653338	+	Missense_Mutation	SNP	G	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr22:46653338G>C	uc003bhh.2	-	1	5882	c.5882C>G	c.(5881-5883)GCT>GGT	p.A1961G		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1961	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTCTGCTGAAGCTTTTCTGTC	0.388													7	41					0	0	0.029380	0	0	
CELSR1	9620	broad.mit.edu	37	22	46929691	46929691	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr22:46929691C>T	uc003bhw.1	-	1	3377	c.3377G>A	c.(3376-3378)TGC>TAC	p.C1126Y		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1126	Extracellular (Potential).|Cadherin 9.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGCCGGGATGCAGCCGATCAC	0.607													13	78					0	0	0.093190	0	0	
GRM7	2917	broad.mit.edu	37	3	6903385	6903385	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:6903385C>T	uc003bqm.2	+	1	584	c.310C>T	c.(310-312)CGG>TGG	p.R104W	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.R104W|GRM7_uc003bql.2_Missense_Mutation_p.R104W	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	104	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GCTGGGCGCGCGGATCCTGGA	0.597													8	42					0	0	0.047766	0	0	
HDAC11	79885	broad.mit.edu	37	3	13538326	13538326	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:13538326C>T	uc003bxy.2	+	4	476	c.343C>T	c.(343-345)CGG>TGG	p.R115W	HDAC11_uc010heb.2_Missense_Mutation_p.R87W|HDAC11_uc011aux.1_Intron|HDAC11_uc003bxz.2_Missense_Mutation_p.R87W|HDAC11_uc011auy.1_Missense_Mutation_p.R64W	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	115	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						GAGGCCCCTTCGGACCCAGAC	0.572											OREG0015411	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	31					0	0	0.069234	0	0	
SETD2	29072	broad.mit.edu	37	3	47098880	47098880	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:47098880G>A	uc003cqs.2	-	15	6447	c.6394C>T	c.(6394-6396)CGG>TGG	p.R2132W	SETD2_uc003cqv.2_Missense_Mutation_p.R2199W|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2132	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.R1629fs*15(1)		kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TGAGCCTCCCGTTGAGCCACC	0.453			N|F|S|Mis		clear cell renal carcinoma								16	115					0	0	0.033300	0	0	
STAB1	23166	broad.mit.edu	37	3	52556844	52556844	+	Missense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:52556844C>A	uc003dej.2	+	62	6872	c.6798C>A	c.(6796-6798)CAC>CAA	p.H2266Q	STAB1_uc003dek.1_Missense_Mutation_p.H281Q|STAB1_uc003del.2_Missense_Mutation_p.H153Q	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2266	Extracellular (Potential).|Link.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCACTGCCCACCCTGTGGTTT	0.612													21	119					7.41877e-09	8.41869e-09	0.062417	1	0	
ROBO2	6092	broad.mit.edu	37	3	77684060	77684060	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:77684060G>T	uc003dpy.3	+	24	4443	c.3800G>T	c.(3799-3801)AGC>ATC	p.S1267I	ROBO2_uc003dpz.2_Missense_Mutation_p.S1332I|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.S1271I	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1267	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CGACCTACCAGCCCATTTTCT	0.468													11	121					0.00010058	0.000104587	0.093190	1	0	
ARL13B	200894	broad.mit.edu	37	3	93758768	93758768	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:93758768G>A	uc003drc.2	+	6	1020	c.734G>A	c.(733-735)GGT>GAT	p.G245D	ARL13B_uc010hop.2_Missense_Mutation_p.G96D|ARL13B_uc003drd.2_Missense_Mutation_p.G138D|ARL13B_uc003dre.2_Missense_Mutation_p.G230D|ARL13B_uc003drf.2_Missense_Mutation_p.G245D|ARL13B_uc003drg.2_Missense_Mutation_p.G142D	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	245	Potential.						GTP binding				0						GGAACCAGTGGTCTGGCTGAG	0.388													4	27					0	0	0.014758	0	0	
COPB2	9276	broad.mit.edu	37	3	139078162	139078162	+	Silent	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:139078162C>A	uc003etf.3	-	18	2383	c.2253G>T	c.(2251-2253)CTG>CTT	p.L751L	COPB2_uc011bmv.1_Silent_p.L722L|COPB2_uc010hui.2_Silent_p.L722L	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	751	WD 9.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						CAGCTTCTGGCAGCCGTCCAG	0.403													10	86					4.68919e-08	5.27534e-08	0.069234	1	0	
CLSTN2	64084	broad.mit.edu	37	3	140282887	140282887	+	Missense_Mutation	SNP	G	A	A	rs140778211		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:140282887G>A	uc003etn.2	+	16	2757	c.2567G>A	c.(2566-2568)CGG>CAG	p.R856Q		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	856	Cytoplasmic (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TACCGGGTCCGGATCGCCCAC	0.547										HNSCC(16;0.037)			24	95					0	0	0.076483	0	0	
CCNL1	57018	broad.mit.edu	37	3	156866355	156866355	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:156866355G>T	uc003fbf.2	-	11	1855	c.1256C>A	c.(1255-1257)TCT>TAT	p.S419Y	CCNL1_uc003fbd.1_Intron|CCNL1_uc003fbe.2_Missense_Mutation_p.S213Y|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA	NM_020307	NP_064703	Q9UK58	CCNL1_HUMAN	cyclin L1	419	RS.				regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			GTATGTTCCAGATCGACTCCG	0.428													10	59					0.000978159	0.000993383	0.080935	1	0	
SI	6476	broad.mit.edu	37	3	164785157	164785157	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr3:164785157T>G	uc003fei.2	-	6	668	c.606A>C	c.(604-606)CAA>CAC	p.Q202H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	202	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCCTAATAACTTGGATGCTAA	0.308										HNSCC(35;0.089)			9	73					0	0	0.047766	0	0	
PIGG	54872	broad.mit.edu	37	4	515701	515701	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr4:515701G>A	uc003gak.3	+	8	1721	c.1585G>A	c.(1585-1587)GTG>ATG	p.V529M	PIGG_uc003gaj.3_Missense_Mutation_p.V521M|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.V396M|PIGG_uc003gal.3_Missense_Mutation_p.V440M|PIGG_uc003gai.2_Intron|PIGG_uc011buw.1_3'UTR|PIGG_uc003gam.2_3'UTR|PIGG_uc003gan.2_Missense_Mutation_p.V440M	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	529					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TCTGACCAACGTGCTCGTGGG	0.572													11	29					0	0	0.069234	0	0	
DCAF4L1	285429	broad.mit.edu	37	4	41984183	41984183	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr4:41984183G>A	uc003gwk.2	+	1	471	c.374G>A	c.(373-375)CGG>CAG	p.R125Q		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	125										skin(1)	1						GTCCCCAACCGGAAGGTGAAG	0.562													16	83					0	0	0.146539	0	0	
UNC5C	8633	broad.mit.edu	37	4	96256683	96256683	+	Missense_Mutation	SNP	T	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr4:96256683T>A	uc003htp.1	-	2	378	c.224A>T	c.(223-225)AAG>ATG	p.K75M	UNC5C_uc010ilc.1_Missense_Mutation_p.K75M|UNC5C_uc003htq.2_Missense_Mutation_p.K75M	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	75	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GGGCTTATTCTTCACAATATA	0.423													12	38					0	0	0.132662	0	0	
TACR3	6870	broad.mit.edu	37	4	104511023	104511023	+	Missense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr4:104511023C>A	uc003hxe.1	-	5	1357	c.1214G>T	c.(1213-1215)AGA>ATA	p.R405I		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	405	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGACTCCATTCTGGTCACGGT	0.507													41	110					1.07121e-22	1.25939e-22	0.092188	1	0	
GYPA	2993	broad.mit.edu	37	4	144918764	144918764	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr4:144918764T>G	uc003ijn.2	-	5	411	c.295A>C	c.(295-297)ATT>CTT	p.I99L	GYPB_uc011chs.1_Intron|GYPB_uc011cht.1_RNA|GYPB_uc011chu.1_RNA|GYPB_uc010ioo.1_Intron|GYPB_uc010iop.2_RNA|GYPB_uc011chv.1_RNA|GYPB_uc011chw.1_Intron|GYPB_uc011chx.1_RNA|GYPB_uc003ijm.1_Missense_Mutation_p.I67L|GYPB_uc011chy.1_RNA|GYPB_uc011chz.1_Intron			P02724	GLPA_HUMAN	SubName: Full=Glycophorin MiX; Flags: Fragment;	96	Helical.				interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)	2	all_hematologic(180;0.15)					ACACACAAAATAATGAGTATT	0.328													7	28					0	0	0.029380	0	0	
KLKB1	3818	broad.mit.edu	37	4	187158094	187158094	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr4:187158094G>A	uc003iyy.2	+	5	559	c.488G>A	c.(487-489)CGG>CAG	p.R163Q	KLKB1_uc011clc.1_5'UTR|KLKB1_uc011cld.1_Missense_Mutation_p.R125Q	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	163	Apple 2.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GCAGAGTACCGGTGAGTACAA	0.413													7	34					0	0	0.038147	0	0	
TTC23L	153657	broad.mit.edu	37	5	34850318	34850318	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:34850318G>T	uc003jiu.2	+	4	387	c.284G>T	c.(283-285)CGA>CTA	p.R95L		NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	95	Potential.						binding			central_nervous_system(1)	1						GAGCTGATTCGATGTGTCATC	0.438													15	174					5.35267e-07	5.89471e-07	0.043863	1	0	
MRPS30	10884	broad.mit.edu	37	5	44809103	44809103	+	Silent	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:44809103T>G	uc003joh.2	+	1	77	c.39T>G	c.(37-39)GGT>GGG	p.G13G	MRPS30_uc003joi.1_5'Flank	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	13					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TGCTACGCGGTCCGAGGCTTT	0.637													3	12					0	0	0.115264	0	0	
HCN1	348980	broad.mit.edu	37	5	45262804	45262804	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:45262804T>G	uc003jok.2	-	8	1917	c.1892A>C	c.(1891-1893)GAG>GCG	p.E631A		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	631	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTGCACCATCTCCCTGTCATG	0.453													31	58					0	0	0.134883	0	0	
HCN1	348980	broad.mit.edu	37	5	45645310	45645310	+	Missense_Mutation	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:45645310T>C	uc003jok.2	-	2	851	c.826A>G	c.(826-828)AGA>GGA	p.R276G		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	276	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TGTATGTATCTAATTAACCTT	0.333													4	32					0	0	0.009096	0	0	
ADAMTS19	171019	broad.mit.edu	37	5	128984623	128984623	+	Silent	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:128984623C>A	uc003kvb.1	+	13	2118	c.2118C>A	c.(2116-2118)TCC>TCA	p.S706S	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	706	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GAACTTCCTCCCCAAAGCATA	0.438													24	109					5.35356e-11	6.18265e-11	0.076483	1	0	
PCDHA9	9752	broad.mit.edu	37	5	140229433	140229433	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:140229433C>T	uc003lhu.2	+	1	2077	c.1353C>T	c.(1351-1353)AAC>AAT	p.N451N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.N451N	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACAACGCACCAGCGT	0.672													18	127					0	0	0.049695	0	0	
PCDHA13	56136	broad.mit.edu	37	5	140261977	140261977	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:140261977G>A	uc003lif.2	+	1	124	c.124G>A	c.(124-126)GGC>AGC	p.G42S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.G42S|PCDHA13_uc003lid.2_Missense_Mutation_p.G42S	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	42	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAAAACACGGCACCTTCGT	0.657													37	116					0	0	0.080422	0	0	
PCDHB4	56131	broad.mit.edu	37	5	140503532	140503532	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:140503532G>A	uc003lip.1	+	1	1952	c.1952G>A	c.(1951-1953)CGC>CAC	p.R651H		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	651	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCCTCCGCGCTCGGCCACC	0.706													8	86					0	0	0.038147	0	0	
PCDHGB2	56103	broad.mit.edu	37	5	140741307	140741307	+	Silent	SNP	C	T	T	rs1860252		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:140741307C>T	uc003ljs.1	+	1	1605	c.1605C>T	c.(1603-1605)CGC>CGT	p.R535R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Silent_p.R535R|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	535	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGGCCCGCGACCAGGGCT	0.687													6	49					0	0	0.029380	0	0	
PCDHGB3	56102	broad.mit.edu	37	5	140752045	140752045	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:140752045C>T	uc003ljw.1	+	1	2084	c.2084C>T	c.(2083-2085)GCG>GTG	p.A695V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.A695V|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	695	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTAGTAGTGGCGTTGGCCTTG	0.572													11	89					0	0	0.069234	0	0	
PCDHGB4	8641	broad.mit.edu	37	5	140768837	140768837	+	Missense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:140768837C>A	uc003lkc.1	+	1	1386	c.1386C>A	c.(1384-1386)AAC>AAA	p.N462K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.N462K	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	462	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCCGAGAACAACCCGCCTG	0.547													21	104					8.34094e-07	9.14699e-07	0.049695	1	0	
ARAP3	64411	broad.mit.edu	37	5	141052170	141052170	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:141052170C>T	uc003llm.2	-	9	1412	c.1334G>A	c.(1333-1335)CGG>CAG	p.R445Q	ARAP3_uc011dbe.1_Missense_Mutation_p.R107Q|ARAP3_uc003lln.2_Missense_Mutation_p.R367Q|ARAP3_uc003llo.1_Missense_Mutation_p.R445Q	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	445	PH 2.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CTTGGTCTCCCGGACGCTGCA	0.637													5	38					0	0	0.014758	0	0	
ZNF454	285676	broad.mit.edu	37	5	178391973	178391973	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr5:178391973A>G	uc003mjo.1	+	5	839	c.568A>G	c.(568-570)AGT>GGT	p.S190G	ZNF454_uc010jkz.1_Missense_Mutation_p.S190G	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	190	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		CTTCTCTAAGAGTTCAACTCT	0.338													8	34					0	0	0.047766	0	0	
ATXN1	6310	broad.mit.edu	37	6	16326864	16326864	+	Missense_Mutation	SNP	C	T	T	rs139918586		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:16326864C>T	uc003nbt.2	-	8	2649	c.1678G>A	c.(1678-1680)GTG>ATG	p.V560M	ATXN1_uc010jpi.2_Missense_Mutation_p.V560M|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	560	Self-association.|Interaction with USP7.|RNA-binding.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GGGGAGGCCACGGACTGCACC	0.632													8	50					0	0	0.047766	0	0	
NUP153	9972	broad.mit.edu	37	6	17629497	17629497	+	Missense_Mutation	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:17629497T>C	uc003ncd.1	-	18	3133	c.2933A>G	c.(2932-2934)AAT>AGT	p.N978S	NUP153_uc011dje.1_Missense_Mutation_p.N1009S|NUP153_uc010jpl.1_Missense_Mutation_p.N936S	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	978					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			AAAATTATCATTCTTACTATC	0.323													8	52					0	0	0.058154	0	0	
SLC44A4	80736	broad.mit.edu	37	6	31833651	31833651	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:31833651G>A	uc010jti.2	-	14	1552	c.1486C>T	c.(1486-1488)CGT>TGT	p.R496C	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	496	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	CATCCTTACCGGAGTGTGCGG	0.602													9	84					0	0	0.058154	0	0	
SCUBE3	222663	broad.mit.edu	37	6	35210049	35210049	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:35210049C>T	uc003okf.1	+	13	1492	c.1486C>T	c.(1486-1488)CTG>TTG	p.L496L	SCUBE3_uc003okg.1_Silent_p.L495L|SCUBE3_uc003okh.1_Silent_p.L383L	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	496					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CCGTTTGCACCTGCGAAACAA	0.527													12	88					0	0	0.093190	0	0	
ABCC10	89845	broad.mit.edu	37	6	43415571	43415571	+	Silent	SNP	C	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:43415571C>G	uc003ouy.1	+	18	4070	c.3855C>G	c.(3853-3855)GGC>GGG	p.G1285G	ABCC10_uc003ouz.1_Silent_p.G1257G|ABCC10_uc010jyo.1_Silent_p.G391G	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1285	ABC transporter 2.|ATP 2 (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CAGGCTCCGGCAAGTCTTCCC	0.652													22	111					0	0	0.055883	0	0	
TDRD6	221400	broad.mit.edu	37	6	46660186	46660186	+	Silent	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:46660186C>A	uc003oyj.2	+	1	4321	c.4321C>A	c.(4321-4323)CGG>AGG	p.R1441R	TDRD6_uc010jze.2_Silent_p.R1435R	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1441					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CTTTTCCCAACGGACCAGCGA	0.388													33	109					8.16721e-17	9.55893e-17	0.045705	1	0	
IMPG1	3617	broad.mit.edu	37	6	76751766	76751766	+	Nonsense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:76751766C>A	uc003pik.1	-	2	275	c.145G>T	c.(145-147)GAA>TAA	p.E49*		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	49					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TACATTTTTTCAGTACTTTCA	0.353													8	79					3.09899e-07	3.44185e-07	0.047766	1	0	
UBE2CBP	90025	broad.mit.edu	37	6	83748171	83748171	+	Missense_Mutation	SNP	G	A	A	rs147405452	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:83748171G>A	uc003pjp.2	-	5	739	c.631C>T	c.(631-633)CGT>TGT	p.R211C	UBE2CBP_uc011dyx.1_RNA|UBE2CBP_uc003pjr.2_Missense_Mutation_p.R179C	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	211						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)		ACCTTGCAACGCTTACAAATT	0.328													7	73					0	0	0.038147	0	0	
PRDM13	59336	broad.mit.edu	37	6	100060991	100060991	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:100060991C>T	uc003pqg.1	+	4	741	c.480C>T	c.(478-480)TGC>TGT	p.C160C		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	160					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		GTTTCCACTGCGTGTTCAGCG	0.627													6	38					0	0	0.021553	0	0	
FOXO3	2309	broad.mit.edu	37	6	108985242	108985242	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:108985242G>A	uc003psk.2	+	3	1522	c.1206G>A	c.(1204-1206)TCG>TCA	p.S402S	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Silent_p.S402S|FOXO3_uc011ean.1_Silent_p.S182S|FOXO3_uc010kdj.1_Silent_p.S182S	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	402					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		CCCAGCCATCGCCCACTGGGG	0.582													17	50					0	0	0.038395	0	0	
TRDN	10345	broad.mit.edu	37	6	123892170	123892170	+	Missense_Mutation	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:123892170A>C	uc003pzj.1	-	2	152	c.130T>G	c.(130-132)TTC>GTC	p.F44V	TRDN_uc003pzk.1_Missense_Mutation_p.F44V|TRDN_uc003pzl.1_Missense_Mutation_p.F44V|TRDN_uc010ken.2_Missense_Mutation_p.F44V|TRDN_uc010keo.1_Missense_Mutation_p.F44V	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	44	Cytoplasmic.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		GGGGAGCTGAACGTCGTCACT	0.463													34	65					0	0	0.054565	0	0	
C6orf174	387104	broad.mit.edu	37	6	127837188	127837188	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:127837188G>A	uc003qbd.2	-	2	1437	c.572C>T	c.(571-573)CCG>CTG	p.P191L		NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	191	Gly-rich.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CCTGGGCGGCGGCGGCTGCGG	0.637													3	11					0	0	0.115264	0	0	
BCLAF1	9774	broad.mit.edu	37	6	136599126	136599126	+	Missense_Mutation	SNP	C	T	T	rs140335385	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:136599126C>T	uc003qgx.1	-	4	1146	c.893G>A	c.(892-894)CGA>CAA	p.R298Q	BCLAF1_uc003qgw.1_Missense_Mutation_p.R298Q|BCLAF1_uc003qgy.1_Missense_Mutation_p.R296Q|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R296Q	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	298					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGGACTTCTTCGTGAAGGGAT	0.468													15	55					0	0	0.119110	0	0	
SHPRH	257218	broad.mit.edu	37	6	146244889	146244889	+	Silent	SNP	C	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:146244889C>G	uc003qlf.2	-	18	3834	c.3435G>C	c.(3433-3435)GTG>GTC	p.V1145V	SHPRH_uc003qld.2_Silent_p.V1154V|SHPRH_uc003qle.2_Silent_p.V1154V|SHPRH_uc003qlg.1_Silent_p.V701V|SHPRH_uc003qlh.2_Silent_p.V70V|SHPRH_uc003qli.1_Silent_p.V70V	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1145					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CTCTGTGGATCACATTTAGCC	0.363													4	38					0	0	0.009096	0	0	
GRM1	2911	broad.mit.edu	37	6	146720447	146720447	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:146720447G>A	uc010khw.1	+	8	2742	c.2272G>A	c.(2272-2274)GGC>AGC	p.G758S	GRM1_uc010khv.1_Missense_Mutation_p.G758S|GRM1_uc003qll.2_Missense_Mutation_p.G758S|GRM1_uc011edz.1_Missense_Mutation_p.G758S|GRM1_uc011eea.1_Missense_Mutation_p.G758S	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	758	Helical; Name=5; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGCCCCTTTGGGCTACAATGG	0.512													11	110					0	0	0.093190	0	0	
PARK2	5071	broad.mit.edu	37	6	162206908	162206908	+	Missense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr6:162206908C>A	uc003qtx.3	-	7	901	c.767G>T	c.(766-768)CGC>CTC	p.R256L	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Missense_Mutation_p.R65L|PARK2_uc003qtw.3_Missense_Mutation_p.R65L|PARK2_uc003qty.3_Missense_Mutation_p.R228L|PARK2_uc003qtz.3_Missense_Mutation_p.R107L|PARK2_uc010kke.1_Missense_Mutation_p.R256L|PARK2_uc011egf.1_5'UTR	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	256	RING-type 1; atypical.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		AATCACGTGGCGGGAGTTGCA	0.502													3	19					0.004672	0.00470808	0.115264	1	0	
MMD2	221938	broad.mit.edu	37	7	4949553	4949553	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr7:4949553C>T	uc003sno.3	-	6	764	c.568G>A	c.(568-570)GTC>ATC	p.V190I	MMD2_uc003snl.1_RNA|MMD2_uc003snn.3_Missense_Mutation_p.V166I|MMD2_uc010ksq.2_Missense_Mutation_p.V166I	NM_001100600	NP_001094070	Q8IY49	PAQRA_HUMAN	monocyte to macrophage	190	Helical; (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		CCCATTACGACGTAGCAGAGA	0.532													6	41					0	0	0.021553	0	0	
KDELR2	11014	broad.mit.edu	37	7	6509271	6509271	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr7:6509271C>T	uc003sqe.3	-	3	468	c.307G>A	c.(307-309)GGA>AGA	p.G103R	DAGLB_uc003sqd.3_Intron|KDELR2_uc003sqf.3_Missense_Mutation_p.G103R	NM_006854	NP_006845	P33947	ERD22_HUMAN	KDEL receptor 2 isoform 1	103	Helical; (Potential).				intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	KDEL sequence binding|protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GAGAGGCCTCCCACAGGGACC	0.363													6	83					0	0	0.029380	0	0	
OSBPL3	26031	broad.mit.edu	37	7	24892212	24892212	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr7:24892212C>T	uc003sxf.2	-	11	1474	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.E357K|OSBPL3_uc003sxh.2_Missense_Mutation_p.E326K|OSBPL3_uc003sxi.2_Missense_Mutation_p.E326K|OSBPL3_uc003sxj.1_Missense_Mutation_p.E122K|OSBPL3_uc003sxk.1_Missense_Mutation_p.E91K	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	357					lipid transport		lipid binding|protein binding			skin(1)	1						TTCTCTCTCTCCGCTGACATG	0.408													13	30					0	0	0.105934	0	0	
PCLO	27445	broad.mit.edu	37	7	82544081	82544081	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr7:82544081T>G	uc003uhx.2	-	7	13510	c.13221A>C	c.(13219-13221)GAA>GAC	p.E4407D	PCLO_uc003uhv.2_Missense_Mutation_p.E4407D|PCLO_uc010lec.2_Missense_Mutation_p.E1372D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4338					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCCGTGATTCTTCCCTCATGT	0.507													11	19					0	0	0.080935	0	0	
SAMD9L	219285	broad.mit.edu	37	7	92763852	92763852	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr7:92763852G>T	uc003umh.1	-	5	2649	c.1433C>A	c.(1432-1434)ACT>AAT	p.T478N	SAMD9L_uc003umj.1_Missense_Mutation_p.T478N|SAMD9L_uc003umi.1_Missense_Mutation_p.T478N|SAMD9L_uc010lfb.1_Missense_Mutation_p.T478N|SAMD9L_uc003umk.1_Missense_Mutation_p.T478N|SAMD9L_uc010lfc.1_Missense_Mutation_p.T478N|SAMD9L_uc010lfd.1_Missense_Mutation_p.T478N|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	478										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CCACATGTTAGTTGTCTTGTC	0.408													9	80					1.12685e-05	1.20044e-05	0.047766	1	0	
DENND2A	27147	broad.mit.edu	37	7	140285420	140285420	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr7:140285420G>A	uc010lnj.2	-	3	1359	c.1214C>T	c.(1213-1215)CCC>CTC	p.P405L	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.P405L|DENND2A_uc003vvw.2_Missense_Mutation_p.P405L|DENND2A_uc003vvx.2_Missense_Mutation_p.P405L	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	405										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GGAAGAGGTGGGAGAAGCAGG	0.527													14	94					0	0	0.132662	0	0	
OR9A2	135924	broad.mit.edu	37	7	142723354	142723354	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr7:142723354C>T	uc003wcc.1	-	1	866	c.866G>A	c.(865-867)CGG>CAG	p.R289Q		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	289	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					TTTGTCATTCCGAAGAGTAAA	0.448													8	72					0	0	0.069234	0	0	
CASP2	835	broad.mit.edu	37	7	143001810	143001810	+	Silent	SNP	C	T	T	rs142190608	byFrequency	TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr7:143001810C>T	uc003wco.2	+	10	1308	c.1161C>T	c.(1159-1161)ATC>ATT	p.I387I	CASP2_uc003wcp.2_3'UTR|CASP2_uc011kta.1_Silent_p.I271I|CASP2_uc003wcq.2_RNA|CASP2_uc011ktb.1_Silent_p.I137I	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	387					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)					CCTGGTACATCGAGGCTCTTG	0.557													14	94					0	0	0.119110	0	0	
CSMD1	64478	broad.mit.edu	37	8	2967856	2967856	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:2967856G>A	uc011kwk.1	-	43	6825	c.6435C>T	c.(6433-6435)GCC>GCT	p.A2145A	CSMD1_uc011kwj.1_Silent_p.A1537A|CSMD1_uc010lrg.2_Silent_p.A213A	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2145	Extracellular (Potential).|Sushi 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACCCACAAGGGGCTGCAAAGG	0.453													4	12					0	0	0.014758	0	0	
GATA4	2626	broad.mit.edu	37	8	11614478	11614478	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:11614478C>T	uc003wuc.2	+	6	1586	c.1032C>T	c.(1030-1032)AGC>AGT	p.S344S	GATA4_uc003wub.1_Silent_p.S138S|GATA4_uc011kxc.1_Silent_p.S345S	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	344					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		CTCCCGCCAGCGGTGCTTCCA	0.617													18	94					0	0	0.043863	0	0	
KCNU1	157855	broad.mit.edu	37	8	36763262	36763262	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:36763262G>T	uc010lvw.2	+	20	2133	c.2046G>T	c.(2044-2046)CAG>CAT	p.Q682H	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	682	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ATTCTGACCAGCTTGATAGCA	0.413													18	82					2.4624e-09	2.8188e-09	0.049695	1	0	
PLAT	5327	broad.mit.edu	37	8	42036423	42036423	+	Missense_Mutation	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:42036423C>T	uc003xos.2	-	13	1731	c.1522G>A	c.(1522-1524)GCC>ACC	p.A508T	PLAT_uc010lxf.1_Missense_Mutation_p.A425T|PLAT_uc010lxg.1_Missense_Mutation_p.A333T|PLAT_uc003xot.2_Missense_Mutation_p.A462T|PLAT_uc011lcm.1_Missense_Mutation_p.A419T|PLAT_uc011lcn.1_Missense_Mutation_p.A382T	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	508	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ACCTGGCAGGCGTCGTGCAAG	0.567													10	72					0	0	0.058154	0	0	
ZFHX4	79776	broad.mit.edu	37	8	77767332	77767332	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:77767332G>T	uc003yav.2	+	10	8427	c.8040G>T	c.(8038-8040)CAG>CAT	p.Q2680H	ZFHX4_uc003yau.1_Missense_Mutation_p.Q2725H|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q2680H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2680						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAGCCCACAGAAATACATCT	0.428										HNSCC(33;0.089)			7	28					0.00198382	0.00200689	0.029380	1	0	
INTS8	55656	broad.mit.edu	37	8	95839622	95839622	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:95839622A>G	uc003yhb.2	+	3	563	c.437A>G	c.(436-438)TAT>TGT	p.Y146C	INTS8_uc003yha.1_Missense_Mutation_p.Y146C|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_5'Flank	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	146					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					GTACTTCTCTATAATAGATGG	0.423													37	115					0	0	0.098360	0	0	
RIMS2	9699	broad.mit.edu	37	8	104987701	104987701	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:104987701G>T	uc003yls.2	+	14	2469	c.2228G>T	c.(2227-2229)AGA>ATA	p.R743I	RIMS2_uc003ylp.2_Missense_Mutation_p.R965I|RIMS2_uc003ylw.2_Missense_Mutation_p.R757I|RIMS2_uc003ylq.2_Missense_Mutation_p.R757I|RIMS2_uc003ylr.2_Missense_Mutation_p.R804I|RIMS2_uc003ylt.2_Missense_Mutation_p.R350I	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1027					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGAAGGACTAGATCATGGTCA	0.363										HNSCC(12;0.0054)			13	38					2.27111e-07	2.53316e-07	0.093190	1	0	
DPYS	1807	broad.mit.edu	37	8	105436539	105436539	+	Silent	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:105436539T>G	uc003yly.3	-	7	1300	c.1171A>C	c.(1171-1173)AGA>CGA	p.R391R		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	391					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTCCTTTTCTTGGATAGAGA	0.373													10	77					0	0	0.069234	0	0	
LRP12	29967	broad.mit.edu	37	8	105509626	105509626	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:105509626T>G	uc003yma.2	-	5	1249	c.1154A>C	c.(1153-1155)AAC>ACC	p.N385T	LRP12_uc003ymb.2_Missense_Mutation_p.N366T|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	385	Extracellular (Potential).|LDL-receptor class A 3.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ACACCCCCAGTTACCTCCACA	0.443													13	62					0	0	0.093190	0	0	
EXT1	2131	broad.mit.edu	37	8	118819534	118819534	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:118819534G>A	uc003yok.1	-	9	2578	c.1805C>T	c.(1804-1806)TCT>TTT	p.S602F		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	602	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			CCGCTCCTTAGAGTTATCCCA	0.537			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				16	67					0	0	0.132662	0	0	
TG	7038	broad.mit.edu	37	8	134107329	134107329	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr8:134107329G>T	uc003ytw.2	+	42	7322	c.7281G>T	c.(7279-7281)GAG>GAT	p.E2427D	TG_uc010mdw.2_Missense_Mutation_p.E1186D|TG_uc011ljb.1_Missense_Mutation_p.E796D|TG_uc011ljc.1_Missense_Mutation_p.E560D|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2427					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCAGCCATGAGAGGGCTCAGC	0.602													17	157					0.000422831	0.000436202	0.146539	1	0	
GLIS3	169792	broad.mit.edu	37	9	4286252	4286252	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr9:4286252G>A	uc003zhx.1	-	2	887	c.174C>T	c.(172-174)CTC>CTT	p.L58L	GLIS3_uc003zic.1_Silent_p.L58L|GLIS3_uc003zie.1_Silent_p.L58L|GLIS3_uc010mhh.1_Intron|GLIS3_uc003zid.1_5'UTR|GLIS3_uc010mhi.1_Intron|GLIS3_uc003zif.1_5'UTR|GLIS3_uc003zig.1_Intron|GLIS3_uc003zih.1_Intron|GLIS3_uc003zii.1_Silent_p.L58L	NM_001042413	NP_001035878	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		TCTTGAGATGGAGGTTGTTAG	0.592													6	59					0	0	0.021553	0	0	
RANBP6	26953	broad.mit.edu	37	9	6014769	6014769	+	Missense_Mutation	SNP	C	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr9:6014769C>G	uc003zjr.2	-	1	850	c.839G>C	c.(838-840)AGT>ACT	p.S280T	RANBP6_uc011lmf.1_Intron|RANBP6_uc003zjs.2_Intron	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	280					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		CTGCAGATTACTAAGCCTAGA	0.423													619	56					0	0	0.139131	0	0	
Unknown	0	broad.mit.edu	37	9	90745686	90745686	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr9:90745686A>G	uc011lti.1	-	4	2295	c.2266T>C	c.(2266-2268)TCC>CCC	p.S756P	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;																		GCCTTCAAGGACCCATGATCA	0.587													12	47					0	0	0.080935	0	0	
DNM1	1759	broad.mit.edu	37	9	131010944	131010944	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr9:131010944G>A	uc011mau.1	+	19	2075	c.1988G>A	c.(1987-1989)CGG>CAG	p.R663Q	DNM1_uc011mat.1_Missense_Mutation_p.R663Q|DNM1_uc004bub.1_Missense_Mutation_p.R36Q|DNM1_uc004buc.1_Missense_Mutation_p.R130Q|DNM1_uc004bud.3_RNA	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	663	GED.				receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						GAGACCATCCGGAATCTTGTG	0.537													41	110					0	0	0.092188	0	0	
NLGN4X	57502	broad.mit.edu	37	X	5811502	5811502	+	Missense_Mutation	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:5811502T>C	uc010ndh.2	-	6	2308	c.1807A>G	c.(1807-1809)ATA>GTA	p.I603V	NLGN4X_uc004crp.2_Missense_Mutation_p.I623V|NLGN4X_uc004crq.2_Missense_Mutation_p.I603V|NLGN4X_uc010ndi.2_Missense_Mutation_p.I640V|NLGN4X_uc004crr.2_Missense_Mutation_p.I603V|NLGN4X_uc010ndj.2_Missense_Mutation_p.I603V	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	603	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TACTGGAATATCTCGTTCAAG	0.488													20	150					0	0	0.043863	0	0	
MAP3K15	389840	broad.mit.edu	37	X	19431478	19431478	+	Missense_Mutation	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:19431478T>C	uc004czk.1	-	11	1659	c.22A>G	c.(22-24)AAT>GAT	p.N8D	MAP3K15_uc004czj.1_5'UTR	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	Error:Variant_position_missing_in_Q6ZN16_after_alignment							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					TCCTTACCATTTCTGTGGGTG	0.393													56	197					0	0	0.139131	0	0	
MAGEB18	286514	broad.mit.edu	37	X	26157428	26157428	+	Missense_Mutation	SNP	A	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:26157428A>G	uc004dbq.1	+	2	513	c.326A>G	c.(325-327)AAG>AGG	p.K109R		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	109	MAGE.						protein binding			central_nervous_system(1)	1						CCTTTAAACAAGAAAGTAGTG	0.418													12	20					0	0	0.080935	0	0	
MAGEB6	158809	broad.mit.edu	37	X	26212528	26212528	+	Missense_Mutation	SNP	C	T	T	rs142927857		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:26212528C>T	uc004dbr.2	+	2	714	c.565C>T	c.(565-567)CGC>TGC	p.R189C	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	189										ovary(3)	3						CATTTTTAAGCGCTTAAGCAA	0.468													19	79					0	0	0.043863	0	0	
DCAF8L1	139425	broad.mit.edu	37	X	27998645	27998645	+	Silent	SNP	T	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:27998645T>C	uc004dbx.1	-	1	922	c.807A>G	c.(805-807)GAA>GAG	p.E269E		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	269	WD 2.									ovary(3)|skin(1)	4						CATTAATTAGTTCTGCTACCC	0.493													18	78					0	0	0.038395	0	0	
MAGEB2	4113	broad.mit.edu	37	X	30237209	30237209	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:30237209T>G	uc004dbz.2	+	2	615	c.512T>G	c.(511-513)GTC>GGC	p.V171G		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	171	MAGE.						protein binding			ovary(1)	1						CTGAATAAAGTCAACCCCAAC	0.502													8	23					0	0	0.038147	0	0	
DMD	1756	broad.mit.edu	37	X	31893328	31893328	+	Missense_Mutation	SNP	G	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:31893328G>T	uc004dda.1	-	48	7319	c.7075C>A	c.(7075-7077)CAA>AAA	p.Q2359K	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.Q1015K|DMD_uc004dcx.2_Missense_Mutation_p.Q1018K|DMD_uc004dcz.2_Missense_Mutation_p.Q2236K|DMD_uc004dcy.1_Missense_Mutation_p.Q2355K|DMD_uc004ddb.1_Missense_Mutation_p.Q2351K|DMD_uc010ngn.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2359			Missing (in DMD).		muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGTCCTTCTTGGTTTGGTTGG	0.333													3	22					2.56e-06	2.77245e-06	0.009096	1	0	
MAGEB16	139604	broad.mit.edu	37	X	35820607	35820607	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:35820607C>T	uc010ngt.1	+	2	573	c.294C>T	c.(292-294)TCC>TCT	p.S98S		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	98										lung(3)|ovary(2)|breast(1)|skin(1)	7						GTCCAAGCTCCTCAGAGGATA	0.478													11	28					0	0	0.069234	0	0	
BCOR	54880	broad.mit.edu	37	X	39933151	39933151	+	Missense_Mutation	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:39933151G>A	uc004den.3	-	4	1740	c.1448C>T	c.(1447-1449)CCG>CTG	p.P483L	BCOR_uc004dep.3_Missense_Mutation_p.P483L|BCOR_uc004deo.3_Missense_Mutation_p.P483L|BCOR_uc004dem.3_Missense_Mutation_p.P483L|BCOR_uc004deq.3_Missense_Mutation_p.P483L	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	483					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TGTTTCTTTCGGAATCTCACT	0.517													15	47					0	0	0.119110	0	0	
CHST7	56548	broad.mit.edu	37	X	46433819	46433819	+	Silent	SNP	C	T	T			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:46433819C>T	uc004dgt.2	+	1	628	c.453C>T	c.(451-453)GGC>GGT	p.G151G		NM_019886	NP_063939	Q9NS84	CHST7_HUMAN	chondroitin 6-sulfotransferase 7	151	Lumenal (Potential).				chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)	3						GCTTGCAGGGCGCGCTGCGCG	0.507													18	69					0	0	0.033300	0	0	
EBP	10682	broad.mit.edu	37	X	48386665	48386665	+	Silent	SNP	C	T	T	rs147786080		TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:48386665C>T	uc004djx.3	+	5	718	c.513C>T	c.(511-513)CGC>CGT	p.R171R	EBP_uc004djy.3_Silent_p.R171R|EBP_uc004djz.2_Silent_p.R171R	NM_006579	NP_006570	Q15125	EBP_HUMAN	emopamil binding protein (sterol isomerase)	171					cholesterol biosynthetic process|skeletal system development	endoplasmic reticulum membrane|integral to plasma membrane	cholestenol delta-isomerase activity|drug transmembrane transporter activity|steroid delta-isomerase activity|transmembrane receptor activity			ovary(1)	1						CAGAGCACCGCGACGGATTCC	0.582													6	30					0	0	0.038147	0	0	
PRICKLE3	4007	broad.mit.edu	37	X	49032238	49032238	+	Silent	SNP	A	C	C			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:49032238A>C	uc004dmy.1	-	9	1658	c.1632T>G	c.(1630-1632)TCT>TCG	p.S544S	PRICKLE3_uc011mmv.1_Silent_p.S476S|PRICKLE3_uc011mmw.1_Silent_p.S463S|PRICKLE3_uc011mmx.1_Silent_p.S506S	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	544	Poly-Ser.						protein binding|zinc ion binding			breast(1)	1						AGCTGGAGCAAGATTCCGAGT	0.502													14	142					0	0	0.119110	0	0	
ITIH5L	347365	broad.mit.edu	37	X	54785377	54785377	+	Missense_Mutation	SNP	T	G	G			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:54785377T>G	uc004dtj.2	-	8	1160	c.1130A>C	c.(1129-1131)AAC>ACC	p.N377T		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	377	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						AGGCTCCTGGTTGCTATGGTT	0.577													3	13					0	0	0.115264	0	0	
OGT	8473	broad.mit.edu	37	X	70767789	70767789	+	Silent	SNP	G	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:70767789G>A	uc004eaa.1	+	5	781	c.564G>A	c.(562-564)CCG>CCA	p.P188P	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.P178P|OGT_uc004eac.2_Silent_p.P49P|OGT_uc004ead.2_5'UTR	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	188	TPR 4.				cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					AGACGCAACCGAACTTTGCAG	0.393													26	123					0	0	0.116897	0	0	
IL1RAPL2	26280	broad.mit.edu	37	X	104478507	104478507	+	Nonsense_Mutation	SNP	C	A	A			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chrX:104478507C>A	uc004elz.1	+	4	1118	c.362C>A	c.(361-363)TCA>TAA	p.S121*		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	121	Ig-like C2-type 1.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						TACAGAAACTCAACATATTGC	0.373													11	162					3.86212e-05	4.08103e-05	0.069234	1	0	
IFT88	8100	broad.mit.edu	37	13	21217687	21217689	+	In_Frame_Del	DEL	AGG	-	-			TCGA-HU-8604-01A-11D-2394-08	TCGA-HU-8604-11A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ffbf151-e573-440e-8950-6f3404f84402	212b32a6-4117-4619-b0b8-90d7c6bb1900	g.chr13:21217687_21217689delAGG	uc001unh.2	+	21	2199_2201	c.1803_1805delAGG	c.(1801-1806)CTAGGA>CTA	p.G602del	IFT88_uc001uni.2_In_Frame_Del_p.G593del|IFT88_uc001unj.2_In_Frame_Del_p.G592del|IFT88_uc010tcq.1_In_Frame_Del_p.G573del	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	602	TPR 10.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TATCTAAGCTAGGAGAATTATAT	0.345													28	64	---	---	---	---						.
