Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LDLRAP1	26119	broad.mit.edu	37	1	25889193	25889193	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:25889193A>G	uc001bkl.3	+	5	632	c.518A>G	c.(517-519)CAG>CGG	p.Q173R	LDLRAP1_uc009vrw.2_5'Flank|LDLRAP1_uc009vrx.2_5'Flank	NM_015627	NP_056442	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein	173	PID.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		GAGTTTTGGCAGGTGTCCAAG	0.383000													23	30					0	0	0.083992	0	0
GTF2B	2959	broad.mit.edu	37	1	89325567	89325567	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:89325567T>C	uc001dmo.3	-	5	652	c.533A>G	c.(532-534)AAA>AGA	p.K178R		NM_001514	NP_001505	Q00403	TF2B_HUMAN	general transcription factor IIB	178	1.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	thyroid hormone receptor binding|translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0131)|Epithelial(280;0.0255)		AAACTTACCTTTAAATGTCCT	0.234000													42	50					0	0	0.104719	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	G	G	rs9424867		TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													8	23					0	0	0.038147	0	0
GOLPH3L	55204	broad.mit.edu	37	1	150634375	150634375	+	Silent	SNP	A	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:150634375A>T	uc001evj.2	-	4	562	c.345T>A	c.(343-345)GGT>GGA	p.G115G	GOLPH3L_uc010pci.1_Silent_p.G71G	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	115						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			GTAAAACATCACCTGTTGGGC	0.383000													32	64					0	0	0.054565	0	0
DENND4B	9909	broad.mit.edu	37	1	153915526	153915526	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:153915526A>T	uc001fdd.1	-	3	799	c.398T>A	c.(397-399)CTG>CAG	p.L133Q		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	133	MABP.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGGAGGGGCCAGGTTTGCTGA	0.637000													24	39					0	0	0.083992	0	0
FAM5C	339479	broad.mit.edu	37	1	190068039	190068039	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:190068039G>C	uc001gse.1	-	8	1642	c.1410C>G	c.(1408-1410)AGC>AGG	p.S470R	FAM5C_uc010pot.1_Missense_Mutation_p.S368R	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	470						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AGAGCCCCTGGCTGAGCATGT	0.577000													35	117					0	0	0.064281	0	0
PCNXL2	80003	broad.mit.edu	37	1	233190130	233190130	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:233190130T>C	uc001hvl.2	-	25	4470	c.4235A>G	c.(4234-4236)AAC>AGC	p.N1412S	PCNXL2_uc001hvk.1_Missense_Mutation_p.N64S|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1412						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				AGAGCTGTAGTTGCCCCAACG	0.438000													17	21					0	0	0.033300	0	0
CUBN	8029	broad.mit.edu	37	10	17157562	17157562	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr10:17157562A>G	uc001ioo.2	-	7	680	c.628T>C	c.(628-630)TGT>CGT	p.C210R		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	210	EGF-like 2; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGGATGCACACTGGGGTCCG	0.542000													35	58					0	0	0.059317	0	0
CCDC6	8030	broad.mit.edu	37	10	61666066	61666066	+	Silent	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr10:61666066T>C	uc001jks.3	-	1	753	c.117A>G	c.(115-117)GGA>GGG	p.G39G		NM_005436	NP_005427	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	39	Poly-Gly.					cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton			ovary(3)|breast(1)	4				Kidney(211;0.0597)		cgccgccgcctcccccgccgc	0.552000													9	31					0	0	0.033300	0	0
IDE	3416	broad.mit.edu	37	10	94239044	94239044	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr10:94239044T>C	uc001kia.2	-	15	1950	c.1874A>G	c.(1873-1875)TAT>TGT	p.Y625C	IDE_uc010qnp.1_Missense_Mutation_p.Y70C|IDE_uc001khz.2_Intron	NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	625					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATACATCCCATAGATGGTATT	0.408000													48	71					0	0	0.139131	0	0
CSNK2A1P	283106	broad.mit.edu	37	11	11373529	11373529	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr11:11373529C>A	uc001mjp.2	-	1	1376	c.1138G>T	c.(1138-1140)GGG>TGG	p.G380W	GALNTL4_uc001mjo.2_Intron	NM_177559	NP_808227			casein kinase II alpha 1 subunit isoform a												0						ACAGGCATCCCAAGGGGGTTG	0.597000													12	10					0.00244969	0.00249969	0.119110	1	0
SLC22A8	9376	broad.mit.edu	37	11	62782340	62782340	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr11:62782340T>C	uc001nwo.2	-	2	227	c.91A>G	c.(91-93)ATG>GTG	p.M31V	SLC22A8_uc001nwp.2_Missense_Mutation_p.M31V|SLC22A8_uc009yom.2_Intron|SLC22A8_uc010rmm.1_Intron|SLC22A8_uc009yon.2_Missense_Mutation_p.M31V	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	31	Extracellular (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						TGGTTGGCCATGTTGAGGATC	0.617000													71	151					0	0	0.139131	0	0
PITPNM1	9600	broad.mit.edu	37	11	67263727	67263727	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr11:67263727T>C	uc001olx.2	-	14	2428	c.2239A>G	c.(2239-2241)AAG>GAG	p.K747E	PITPNM1_uc001olw.2_Missense_Mutation_p.K29E|PITPNM1_uc001oly.2_Missense_Mutation_p.K747E|PITPNM1_uc001olz.2_Missense_Mutation_p.K746E	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	747	DDHD.				brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						GCCTGGAACTTCGGGGCCAGC	0.642000													29	32					0	0	0.144211	0	0
ALG9	79796	broad.mit.edu	37	11	111715419	111715419	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr11:111715419A>G	uc001pmb.2	-	10	1022	c.923T>C	c.(922-924)ATT>ACT	p.I308T	ALG9_uc001ply.2_Missense_Mutation_p.I137T|ALG9_uc001plz.2_Missense_Mutation_p.I137T|ALG9_uc010rwm.1_Missense_Mutation_p.I308T|ALG9_uc010rwn.1_Missense_Mutation_p.I262T|ALG9_uc010rwo.1_Missense_Mutation_p.I136T|ALG9_uc009yyh.1_Missense_Mutation_p.I203T	NM_001077690	NP_001071158	Q9H6U8	ALG9_HUMAN	asparagine-linked glycosylation 9 protein	308	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			large_intestine(1)|ovary(1)	2		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		AAATCCATTAATTAAATAGAA	0.393000													36	43					0	0	0.059317	0	0
NCAPD2	9918	broad.mit.edu	37	12	6638743	6638743	+	Silent	SNP	C	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr12:6638743C>A	uc001qoo.2	+	28	3683	c.3637C>A	c.(3637-3639)CGG>AGG	p.R1213R	NCAPD2_uc010sfd.1_Silent_p.R1168R	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1213					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						GCTGTGTCAGCGGTTCCGCAC	0.602000													17	80					2.35188e-11	2.64256e-11	0.038395	1	0
OS9	10956	broad.mit.edu	37	12	58087952	58087952	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr12:58087952C>T	uc001spj.2	+	1	67	c.8C>T	c.(7-9)GCG>GTG	p.A3V	OS9_uc010srx.1_Missense_Mutation_p.A3V|OS9_uc001spk.2_Missense_Mutation_p.A3V|OS9_uc001spl.2_Missense_Mutation_p.A3V|OS9_uc001spm.2_Missense_Mutation_p.A3V|OS9_uc001spn.2_Missense_Mutation_p.A3V|OS9_uc010sry.1_Missense_Mutation_p.A3V|OS9_uc010srz.1_Missense_Mutation_p.A3V	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	3					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			AAGATGGCGGCGGAAACGCTG	0.582000													59	157					0	0	0.139131	0	0
LOC284232	284232	broad.mit.edu	37	13	19414170	19414170	+	RNA	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr13:19414170T>C	uc010tcj.1	-	1		c.31940A>G				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						GATTGAACAGTTGGTTCAAGT	0.269000													4	14					0	0	0.029380	0	0
ESD	2098	broad.mit.edu	37	13	47345616	47345616	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr13:47345616A>G	uc001vbn.2	-	10	967	c.784T>C	c.(784-786)TAC>CAC	p.Y262H	ESD_uc001vbo.2_3'UTR	NM_001984	NP_001975	P10768	ESTD_HUMAN	esterase D/formylglutathione hydrolase	262						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			ovary(1)	1		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	ATGAAGTAGTAGCTATGATCA	0.328000													17	51					0	0	0.146539	0	0
ATP7B	540	broad.mit.edu	37	13	52511445	52511445	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr13:52511445T>G	uc001vfw.2	-	19	4145	c.3988A>C	c.(3988-3990)ATT>CTT	p.I1330L	ATP7B_uc010adv.2_Missense_Mutation_p.I900L|ATP7B_uc001vfx.2_Missense_Mutation_p.I1123L|ATP7B_uc001vfy.2_Missense_Mutation_p.I1219L|ATP7B_uc010tgt.1_Missense_Mutation_p.I1265L|ATP7B_uc010tgu.1_Missense_Mutation_p.I1282L|ATP7B_uc010tgv.1_Missense_Mutation_p.I1252L|ATP7B_uc001vfv.2_Missense_Mutation_p.I602L|ATP7B_uc010tgs.1_Missense_Mutation_p.I541L	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1330	Helical; (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		AGGTTATAAATCAGTGCCAGG	0.532000									Wilson_disease				29	36					0	0	0.125774	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756790	94756790	+	Silent	SNP	C	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr14:94756790C>T	uc001yct.2	-	2	607	c.141G>A	c.(139-141)GAG>GAA	p.E47E	SERPINA10_uc001ycu.3_Silent_p.E47E	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	47					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		CTTCCTCTTCCTCCTTGGGAG	0.622000													8	19					0	0	0.093190	0	0
ADAM6	8755	broad.mit.edu	37	14	106774188	106774188	+	RNA	SNP	G	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr14:106774188G>T	uc010tyt.1	-	430		c.15573C>A								Parts of antibodies, mostly variable regions.												0						CATACGTTAGGTTCCCAGTGT	0.512000													9	28					3.09899e-07	3.33224e-07	0.047766	1	0
MYO1E	4643	broad.mit.edu	37	15	59515313	59515313	+	Silent	SNP	C	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr15:59515313C>G	uc002aga.2	-	9	1227	c.855G>C	c.(853-855)CTG>CTC	p.L285L		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	285	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		TGATGTTTCCCAGGTGGAGAA	0.507000													8	44					0	0	0.038147	0	0
RORA	6095	broad.mit.edu	37	15	60849084	60849084	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr15:60849084T>C	uc002agv.2	-	3	419	c.263A>G	c.(262-264)GAA>GGA	p.E88G	RORA_uc002agt.3_Intron|RORA_uc002agw.2_Intron|RORA_uc002agx.2_Intron	NM_134260	NP_599022	P35398	RORA_HUMAN	RAR-related orphan receptor A isoform b	88	Modulating.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTCCTTATCTTCCTTTTGTGA	0.403000													72	69					0	0	0.139131	0	0
GFER	2671	broad.mit.edu	37	16	2035934	2035934	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr16:2035934A>C	uc002cob.2	+	3	593	c.523A>C	c.(523-525)AAT>CAT	p.N175H	GFER_uc002coc.2_Missense_Mutation_p.N100H	NM_005262	NP_005253	P55789	ALR_HUMAN	erv1-like growth factor	175	ERV/ALR sulfhydryl oxidase.				cell proliferation|spermatogenesis	extracellular region|mitochondrial intermembrane space	growth factor activity|thiol oxidase activity				0						CCACCTGCACAATGAAGTGAA	0.587000													110	73					0	0	0.139131	0	0
GFER	2671	broad.mit.edu	37	16	2035967	2035967	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr16:2035967T>A	uc002cob.2	+	3	626	c.556T>A	c.(556-558)TTC>ATC	p.F186I	GFER_uc002coc.2_Missense_Mutation_p.F111I	NM_005262	NP_005253	P55789	ALR_HUMAN	erv1-like growth factor	186	ERV/ALR sulfhydryl oxidase.				cell proliferation|spermatogenesis	extracellular region|mitochondrial intermembrane space	growth factor activity|thiol oxidase activity				0						CAAGCCTGACTTCGACTGCTC	0.612000													92	62					0	0	0.139131	0	0
BFAR	51283	broad.mit.edu	37	16	14755823	14755823	+	Silent	SNP	G	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr16:14755823G>T	uc002dco.2	+	6	1139	c.858G>T	c.(856-858)CTG>CTT	p.L286L	BFAR_uc002dcp.2_Silent_p.L161L|BFAR_uc010uzh.1_Silent_p.L158L	NM_016561	NP_057645	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	286	Lumenal (Potential).				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			ovary(1)|skin(1)	2						TGCTCTACCTGTACCTGTTTG	0.567000													146	105					1.02779e-63	1.22355e-63	0.139131	1	0
XYLT1	64131	broad.mit.edu	37	16	17202725	17202725	+	Nonsense_Mutation	SNP	C	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr16:17202725C>A	uc002dfa.2	-	12	2792	c.2707G>T	c.(2707-2709)GAG>TAG	p.E903*		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	903	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						AGCCATCCCTCCAGCGCTGTG	0.667000													7	103					0.00307968	0.00311079	0.038147	1	0
SLC12A4	6560	broad.mit.edu	37	16	67982000	67982000	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr16:67982000G>A	uc002euz.2	-	14	1952	c.1811C>T	c.(1810-1812)ACC>ATC	p.T604I	SLC12A4_uc010ceu.2_Missense_Mutation_p.T598I|SLC12A4_uc010vkh.1_Missense_Mutation_p.T573I|SLC12A4_uc010vki.1_Missense_Mutation_p.T604I|SLC12A4_uc010vkj.1_Missense_Mutation_p.T606I|SLC12A4_uc002eva.2_Missense_Mutation_p.T604I|SLC12A4_uc010cev.1_5'Flank|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	604	Cytoplasmic (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCAGTTGGGGGTCCTCAGGAG	0.617000													51	163					0	0	0.139131	0	0
KIAA0664	23277	broad.mit.edu	37	17	2595388	2595388	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr17:2595388G>T	uc002fuy.1	-	23	3533	c.3447C>A	c.(3445-3447)CAC>CAA	p.H1149Q	KIAA0664_uc002fux.1_Missense_Mutation_p.H1082Q|KIAA0664_uc010ckc.1_Missense_Mutation_p.H135Q	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	1149	TPR 4.						binding			breast(2)	2						CGACAAGGTGGTGGCTGCCGG	0.667000													8	3					1.12685e-05	1.18616e-05	0.047766	1	0
NDEL1	81565	broad.mit.edu	37	17	8350137	8350137	+	Silent	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr17:8350137T>C	uc002glj.2	+	4	503	c.306T>C	c.(304-306)AGT>AGC	p.S102S	NDEL1_uc002gli.2_Silent_p.S102S	NM_030808	NP_110435	Q9GZM8	NDEL1_HUMAN	nudE nuclear distribution gene E homolog (A.	102	Interaction with KATNB1 (By similarity).|Potential.|Self-association (By similarity).				chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|microtubule|spindle					0						ATGATTTAAGTCAGACTCGGG	0.463000													50	50					0	0	0.139131	0	0
IGFBP4	3487	broad.mit.edu	37	17	38612795	38612795	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr17:38612795A>G	uc002hus.2	+	4	1049	c.737A>G	c.(736-738)GAG>GGG	p.E246G		NM_001552	NP_001543	P22692	IBP4_HUMAN	insulin-like growth factor binding protein 4	246	Thyroglobulin type-1.				DNA metabolic process|signal transduction|skeletal system development						0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			CCAAAGGGGGAGCTGGACTGC	0.657000													21	67					0	0	0.069288	0	0
ACLY	47	broad.mit.edu	37	17	40025023	40025023	+	Silent	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr17:40025023T>C	uc002hyg.2	-	28	3313	c.3150A>G	c.(3148-3150)GAA>GAG	p.E1050E	ACLY_uc002hyh.2_Silent_p.E1040E|ACLY_uc002hyi.2_Silent_p.E1104E|ACLY_uc010wfx.1_Silent_p.E1094E|ACLY_uc010wfy.1_Silent_p.E779E	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	1050					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				TGTCAATATATTCATCAGCTT	0.438000													36	115					0	0	0.080422	0	0
CSNK1D	1453	broad.mit.edu	37	17	80202675	80202675	+	Silent	SNP	C	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr17:80202675C>T	uc002kej.2	-	9	1546	c.1230G>A	c.(1228-1230)CAG>CAA	p.Q410Q	SLC16A3_uc002kee.2_Intron|CSNK1D_uc002kef.2_Intron|CSNK1D_uc002kei.2_3'UTR|CSNK1D_uc002keg.1_RNA|CSNK1D_uc010dil.2_RNA|CSNK1D_uc002keh.2_3'UTR	NM_001893	NP_001884	P48730	KC1D_HUMAN	casein kinase 1, delta isoform 1	410					circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)	2	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			GCACGACAGACTGAAGACCAC	0.557000											OREG0024822	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	37					0	0	0.104719	0	0
SMARCA4	6597	broad.mit.edu	37	19	11132430	11132430	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr19:11132430A>T	uc002mqf.3	+	19	2930	c.2646A>T	c.(2644-2646)GAA>GAT	p.E882D	SMARCA4_uc010dxp.2_Missense_Mutation_p.E882D|SMARCA4_uc010dxo.2_Missense_Mutation_p.E882D|SMARCA4_uc002mqg.1_Missense_Mutation_p.E882D|SMARCA4_uc010dxq.2_Missense_Mutation_p.E882D|SMARCA4_uc010dxr.2_Missense_Mutation_p.E882D|SMARCA4_uc002mqj.3_Missense_Mutation_p.E882D|SMARCA4_uc010dxs.2_Missense_Mutation_p.E882D|SMARCA4_uc010dxt.1_Missense_Mutation_p.E102D|SMARCA4_uc002mqh.3_Missense_Mutation_p.E5D|SMARCA4_uc002mqi.1_Missense_Mutation_p.E85D	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	882	Helicase ATP-binding.|DEGH box.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TTGTGGACGAAGGTCACCGCA	0.632000			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				11	22					0	0	0.069234	0	0
KLK14	43847	broad.mit.edu	37	19	51581412	51581412	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr19:51581412T>C	uc002pvs.1	-	7	875	c.656A>G	c.(655-657)GAC>GGC	p.D219G		NM_022046	NP_071329	Q9P0G3	KLK14_HUMAN	kallikrein 14 preproprotein	219	Peptidase S1.				epidermis morphogenesis|fertilization|negative regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis|seminal clot liquefaction	extracellular space	serine-type endopeptidase activity			skin(1)	1		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00422)		TCCCCCAGAGTCACCCTGAGG	0.622000													3	31					0	0	0.115264	0	0
SAPS1	22870	broad.mit.edu	37	19	55752903	55752903	+	Nonsense_Mutation	SNP	A	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr19:55752903A>T	uc002qjw.3	-	8	1192	c.950T>A	c.(949-951)TTG>TAG	p.L317*	SAPS1_uc002qjv.2_Nonsense_Mutation_p.L379*	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	317	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		TAGGGCGTGCAAGGCGCCCAC	0.672000													4	11					0	0	0.009096	0	0
NCKAP5	344148	broad.mit.edu	37	2	133721438	133721438	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr2:133721438T>G	uc002ttp.2	-	8	808	c.434A>C	c.(433-435)AAG>ACG	p.K145T	NCKAP5_uc002ttq.2_Missense_Mutation_p.K145T|NCKAP5_uc002tts.1_Missense_Mutation_p.K120T	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	145	Potential.						protein binding				0						CTCTGACAGCTTTTCCTGAAG	0.428000													35	57					0	0	0.064281	0	0
ACVR2A	92	broad.mit.edu	37	2	148677893	148677893	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr2:148677893G>A	uc002twg.2	+	9	1326	c.1057G>A	c.(1057-1059)GCA>ACA	p.A353T	ACVR2A_uc010zbn.1_Missense_Mutation_p.A245T|ACVR2A_uc002twh.2_Missense_Mutation_p.A353T	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	353	Cytoplasmic (Potential).|Protein kinase.				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		TGGCAAGTCTGCAGGCGATAC	0.383000													31	50					0	0	0.045705	0	0
NEB	4703	broad.mit.edu	37	2	152482148	152482148	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr2:152482148A>G	uc010fnx.2	-	67	9814	c.9623T>C	c.(9622-9624)TTA>TCA	p.L3208S		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3208	Nebulin 87.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTGTGTATAAGCGCTGTGA	0.358000													8	15					0	0	0.038147	0	0
SSFA2	6744	broad.mit.edu	37	2	182778659	182778659	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr2:182778659A>T	uc002uoi.2	+	10	1896	c.1574A>T	c.(1573-1575)CAG>CTG	p.Q525L	SSFA2_uc002uoh.2_Missense_Mutation_p.Q525L|SSFA2_uc002uoj.2_Missense_Mutation_p.Q525L|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.Q372L|SSFA2_uc002uol.2_Missense_Mutation_p.Q372L|SSFA2_uc002uom.2_5'Flank	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	525						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			AATCATCTTCAGGTAAAATTT	0.318000													20	17					0	0	0.043863	0	0
ICOS	29851	broad.mit.edu	37	2	204822592	204822592	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr2:204822592A>C	uc002vam.2	+	4	639	c.572A>C	c.(571-573)AAA>ACA	p.K191T	ICOS_uc010zip.1_Missense_Mutation_p.K191T|ICOS_uc010fua.2_Intron	NM_012092	NP_036224	Q9Y6W8	ICOS_HUMAN	inducible T-cell co-stimulator precursor	191	Cytoplasmic (Potential).				immune response|T cell costimulation	extracellular region					0						ACAGCCAAAAAATCTAGACTC	0.388000													28	44					0	0	0.144211	0	0
DNPEP	23549	broad.mit.edu	37	2	220239739	220239739	+	Silent	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr2:220239739G>A	uc010zlg.1	-	14	1351	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	DNPEP_uc010zlf.1_RNA|DNPEP_uc002vle.2_Silent_p.L415L|DNPEP_uc002vlf.1_Silent_p.L401L|DNPEP_uc002vlh.2_Silent_p.L362L|DNPEP_uc002vli.1_Silent_p.L362L	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	405					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	TCCGGACCATGAGATCCTAGG	0.582000													22	33					0	0	0.055883	0	0
DNMT3B	1789	broad.mit.edu	37	20	31375212	31375212	+	Silent	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr20:31375212G>A	uc002wyc.2	+	6	930	c.609G>A	c.(607-609)CCG>CCA	p.P203P	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Silent_p.P203P|DNMT3B_uc002wye.2_Silent_p.P203P|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Silent_p.P161P|DNMT3B_uc010zua.1_Silent_p.P127P|DNMT3B_uc002wyf.2_Silent_p.P215P	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	203	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						TGGAGTCCCCGCAGGTGGAGG	0.637000													44	30					0	0	0.124865	0	0
NCOA6	23054	broad.mit.edu	37	20	33330861	33330861	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr20:33330861T>C	uc002xav.2	-	12	5770	c.3199A>G	c.(3199-3201)AGA>GGA	p.R1067G	NCOA6_uc002xaw.2_Missense_Mutation_p.R1067G	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1067	NCOA1-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						ATGGGCATTCTCTGGGAGTCG	0.537000													191	113					0	0	0.139131	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47628617	47628617	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr20:47628617C>A	uc002xtx.3	+	28	4066	c.3914C>A	c.(3913-3915)CCT>CAT	p.P1305H	ARFGEF2_uc010zyf.1_Missense_Mutation_p.P598H	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1305					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TCTGAGAGGCCTCGGGTTCGT	0.512000													46	144					6.32628e-17	7.35614e-17	0.139131	1	0
APOL6	80830	broad.mit.edu	37	22	36055131	36055131	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr22:36055131C>G	uc003aoe.2	+	3	814	c.520C>G	c.(520-522)CTT>GTT	p.L174V	APOL6_uc003aod.2_RNA	NM_030641	NP_085144	Q9BWW8	APOL6_HUMAN	apolipoprotein L6	174					lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity				0						TATCTATAATCTTAGAAACAC	0.493000													8	57					0	0	0.038147	0	0
GOLGB1	2804	broad.mit.edu	37	3	121433805	121433805	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr3:121433805G>A	uc003eei.3	-	10	1418	c.1292C>T	c.(1291-1293)TCC>TTC	p.S431F	GOLGB1_uc010hrc.2_Missense_Mutation_p.S436F|GOLGB1_uc003eej.3_Missense_Mutation_p.S397F|GOLGB1_uc011bjm.1_Missense_Mutation_p.S317F|GOLGB1_uc010hrd.1_Missense_Mutation_p.S395F	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	431	Potential.|Cytoplasmic (Potential).				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AATTTCTTTGGATTTTTGCTG	0.328000													30	29					0	0	0.134883	0	0
TNIP2	79155	broad.mit.edu	37	4	2746482	2746482	+	Missense_Mutation	SNP	G	A	A	rs150823075		TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr4:2746482G>A	uc003gfg.2	-	4	935	c.848C>T	c.(847-849)GCG>GTG	p.A283V	TNIP2_uc003gff.2_Missense_Mutation_p.A176V|TNIP2_uc003gfh.2_Intron	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	283	Potential.					cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCTGGAGGCCGCCAGCTCCTG	0.607000													44	54					0	0	0.111260	0	0
DCUN1D4	23142	broad.mit.edu	37	4	52765463	52765463	+	Silent	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr4:52765463T>C	uc003gze.2	+	8	667	c.534T>C	c.(532-534)AAT>AAC	p.N178N	DCUN1D4_uc003gzf.2_Silent_p.N178N|DCUN1D4_uc011bzn.1_Silent_p.N118N|DCUN1D4_uc003gzg.2_RNA|DCUN1D4_uc003gzh.2_RNA|DCUN1D4_uc011bzo.1_Silent_p.N222N	NM_001040402	NP_001035492	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain	178	DCUN1.									ovary(2)	2			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			AACTCAGAAATACTTTGGATT	0.299000													8	15					0	0	0.058154	0	0
PDE5A	8654	broad.mit.edu	37	4	120446828	120446828	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr4:120446828T>A	uc003idh.2	-	12	1810	c.1655A>T	c.(1654-1656)CAG>CTG	p.Q552L	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.Q510L|PDE5A_uc003idg.2_Missense_Mutation_p.Q500L|uc003idi.3_Intron	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	552					platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	TTTAAGGGTCTGGGCAGATGG	0.413000													38	59					0	0	0.080422	0	0
HMGB2	3148	broad.mit.edu	37	4	174254247	174254247	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr4:174254247T>C	uc011ckc.1	-	2	389	c.269A>G	c.(268-270)AAG>AGG	p.K90R	HMGB2_uc003ita.3_Missense_Mutation_p.K90R|HMGB2_uc003itb.2_Missense_Mutation_p.K90R|HMGB2_uc003itc.2_Missense_Mutation_p.K90R	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	90					base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		ATTGGGGTCCTTTTTCTTCCC	0.398000													91	149					0	0	0.139131	0	0
SNX25	83891	broad.mit.edu	37	4	186188140	186188140	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr4:186188140G>A	uc003ixh.2	+	5	619	c.430G>A	c.(430-432)GAG>AAG	p.E144K		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	144	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		GCCGGTAGTGGAGTTACTGAG	0.423000													34	48					0	0	0.064281	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1323010	1323010	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr5:1323010T>C	uc003jch.2	-	13	1343	c.1297A>G	c.(1297-1299)ATC>GTC	p.I433V	CLPTM1L_uc003jcg.2_Missense_Mutation_p.I264V	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like	433	Helical; (Potential).				apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		AAGCTGTTGATTAACCAGGAG	0.388000													37	83					0	0	0.080422	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5240027	5240027	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr5:5240027C>G	uc003jdl.2	+	16	2650	c.2512C>G	c.(2512-2514)CTG>GTG	p.L838V	ADAMTS16_uc003jdk.1_Missense_Mutation_p.L838V	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	838	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CAACGAGACACTGATTGTGGA	0.478000													12	102					0	0	0.119110	0	0
PDZD2	23037	broad.mit.edu	37	5	32059458	32059458	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr5:32059458C>A	uc003jhl.2	+	13	2702	c.2314C>A	c.(2314-2316)CTG>ATG	p.L772M	PDZD2_uc003jhm.2_Missense_Mutation_p.L772M|PDZD2_uc011cnx.1_Missense_Mutation_p.L598M	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	772	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GGAGAGCAACCTGAGGTTTGT	0.448000													20	29					2.94398e-08	3.23515e-08	0.043863	1	0
C5orf42	65250	broad.mit.edu	37	5	37181023	37181023	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr5:37181023C>T	uc011cpa.1	-	27	5737	c.5506G>A	c.(5506-5508)GTA>ATA	p.V1836I	C5orf42_uc011coy.1_Missense_Mutation_p.V337I|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.V911I	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1836										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GGAGTTGCTACTGCAACTGAA	0.403000													21	37					0	0	0.062417	0	0
DAB2	1601	broad.mit.edu	37	5	39394411	39394411	+	Silent	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr5:39394411T>C	uc003jlx.2	-	2	543	c.12A>G	c.(10-12)GAA>GAG	p.E4E	DAB2_uc003jlw.2_Silent_p.E4E	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	4					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			TTGTTTCTACTTCGTTAGACA	0.478000													28	35					0	0	0.125774	0	0
FBN2	2201	broad.mit.edu	37	5	127641530	127641530	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr5:127641530G>C	uc003kuu.2	-	43	5972	c.5533C>G	c.(5533-5535)CTG>GTG	p.L1845V		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1845	EGF-like 29; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CAAACCAACAGCAGGTCATTG	0.363000													11	98					0	0	0.069234	0	0
RUFY1	80230	broad.mit.edu	37	5	178987050	178987050	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr5:178987050A>G	uc003mka.1	+	2	335	c.335A>G	c.(334-336)GAG>GGG	p.E112G	RUFY1_uc003mkb.1_Missense_Mutation_p.E4G|RUFY1_uc003mkc.1_Missense_Mutation_p.E4G	NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	112					endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGATGGAGGAGCGTGCCAAC	0.597000										HNSCC(44;0.11)			13	11					0	0	0.146539	0	0
DDAH2	23564	broad.mit.edu	37	6	31696435	31696435	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr6:31696435C>T	uc003nwp.2	-	2	1016	c.385G>A	c.(385-387)GTT>ATT	p.V129I	DDAH2_uc003nwq.2_Missense_Mutation_p.V129I	NM_013974	NP_039268	O95865	DDAH2_HUMAN	dimethylarginine dimethylaminohydrolase 2	129					anti-apoptosis|arginine catabolic process|citrulline metabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction	cytoplasm	dimethylargininase activity|protein binding				0					L-Citrulline(DB00155)	GTGAAGAGAACGTCAGTGCCA	0.572000													16	22					0	0	0.033300	0	0
GSTA1	2938	broad.mit.edu	37	6	52658943	52658943	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr6:52658943A>G	uc003paz.2	-	5	506	c.394T>C	c.(394-396)TAC>CAC	p.Y132H		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	132	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	GCAGGGAAGTAGCGATTTTTT	0.433000													98	191					0	0	0.139131	0	0
IBTK	25998	broad.mit.edu	37	6	82904254	82904254	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr6:82904254T>G	uc003pjl.1	-	23	3807	c.3280A>C	c.(3280-3282)ATT>CTT	p.I1094L	IBTK_uc011dyu.1_Missense_Mutation_p.I45L|IBTK_uc011dyv.1_Missense_Mutation_p.I1079L|IBTK_uc011dyw.1_Missense_Mutation_p.I893L|IBTK_uc010kbi.1_Missense_Mutation_p.I788L|IBTK_uc003pjm.2_Missense_Mutation_p.I1094L	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	1094					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TTACTGGGAATAGGCTGTGGA	0.368000													19	22					0	0	0.049695	0	0
KLHL32	114792	broad.mit.edu	37	6	97562031	97562031	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr6:97562031G>T	uc010kcm.1	+	7	1472	c.1000G>T	c.(1000-1002)GTG>TTG	p.V334L	KLHL32_uc003poy.2_Missense_Mutation_p.V334L|KLHL32_uc011ead.1_Missense_Mutation_p.V298L|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Missense_Mutation_p.V265L|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	334	Kelch 1.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TCCCATGCCTGTGGGAAGGAG	0.562000													6	84					0.00116845	0.00120458	0.021553	1	0
RGS17	26575	broad.mit.edu	37	6	153332802	153332802	+	Silent	SNP	A	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr6:153332802A>T	uc003qpm.2	-	5	696	c.540T>A	c.(538-540)ACT>ACA	p.T180T		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	180	RGS.				negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		TGTGCATTAAAGTATATATCT	0.353000									Lung_Cancer_Familial_Clustering_of				9	30					0	0	0.058154	0	0
PPIA	5478	broad.mit.edu	37	7	44839397	44839397	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr7:44839397G>T	uc003tlw.2	+	4	369	c.286G>T	c.(286-288)GGC>TGC	p.G96C	PPIA_uc003tlx.2_RNA|PPIA_uc010kyl.2_RNA	NM_021130	NP_066953	P62937	PPIA_HUMAN	peptidylprolyl isomerase A	96	PPIase cyclophilin-type.				entry into host cell|leukocyte migration|platelet activation|platelet degranulation|protein folding|provirus integration|regulation of viral genome replication|RNA-dependent DNA replication|uncoating of virus	cytosol|extracellular region|nucleus	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding|virion binding				0					Cyclosporine(DB00091)|L-Proline(DB00172)	TACGGGTCCTGGCATCTTGTC	0.483000													22	94					1.96292e-10	2.18102e-10	0.055883	1	0
CUL1	8454	broad.mit.edu	37	7	148495672	148495672	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr7:148495672T>C	uc010lpg.2	+	20	2565	c.2039T>C	c.(2038-2040)TTA>TCA	p.L680S	CUL1_uc003wey.2_Missense_Mutation_p.L680S|CUL1_uc003wez.2_Missense_Mutation_p.L570S|CUL1_uc003wfa.2_Missense_Mutation_p.L341S	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	680					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			AGTAAGAAATTAAGGGTTAAC	0.383000													46	31					0	0	0.111260	0	0
MFHAS1	9258	broad.mit.edu	37	8	8654999	8654999	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr8:8654999C>G	uc003wsj.1	-	2	3564	c.3001G>C	c.(3001-3003)GAG>CAG	p.E1001Q		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	1001		Breakpoint for translocation to form chimeric MASL1.									0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		CTCAGCAACTCCCCTGTAGGA	0.552000													3	48					0	0	0.115264	0	0
SLC7A2	6542	broad.mit.edu	37	8	17419589	17419589	+	Silent	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr8:17419589G>A	uc011kyc.1	+	10	1810	c.1641G>A	c.(1639-1641)CAG>CAA	p.Q547Q	SLC7A2_uc011kyd.1_Silent_p.L586L|SLC7A2_uc011kye.1_Silent_p.Q587Q|SLC7A2_uc011kyf.1_Silent_p.L547L	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	547	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	TCTGGAGGCAGCCCCAGAATC	0.468000													28	32					0	0	0.108266	0	0
KIAA0196	9897	broad.mit.edu	37	8	126085409	126085409	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr8:126085409T>G	uc003yrt.2	-	9	1465	c.1136A>C	c.(1135-1137)CAT>CCT	p.H379P	KIAA0196_uc011lir.1_Missense_Mutation_p.H231P	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	379					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GTCTGCTGTATGAAGCATCAG	0.448000													32	44					0	0	0.059317	0	0
ADCY8	114	broad.mit.edu	37	8	132052526	132052526	+	Silent	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr8:132052526G>A	uc003ytd.3	-	1	310	c.54C>T	c.(52-54)ATC>ATT	p.I18I	ADCY8_uc010mds.2_Silent_p.I18I	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	18	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GCGTCGGGTGGATGGTGTAGA	0.697000										HNSCC(32;0.087)			4	3					0	0	0.009096	0	0
BAI1	575	broad.mit.edu	37	8	143623373	143623373	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr8:143623373G>C	uc003ywm.2	+	27	3961	c.3778G>C	c.(3778-3780)GAG>CAG	p.E1260Q		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1260	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GTCTCTGCCCGAGGAGGAGAA	0.682000													3	18					0	0	0.115264	0	0
CYP11B1	1584	broad.mit.edu	37	8	143957217	143957217	+	Silent	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr8:143957217G>A	uc003yxi.2	-	6	1039	c.1032C>T	c.(1030-1032)AGC>AGT	p.S344S	CYP11B1_uc010mex.2_Silent_p.S20S|CYP11B1_uc003yxh.2_Silent_p.S60S|CYP11B1_uc003yxj.2_Silent_p.S344S|CYP11B1_uc010mey.2_Silent_p.S415S	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	344					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CGGCGGCCAGGCTCTCCTGGC	0.652000									Familial_Hyperaldosteronism_type_I				57	80					0	0	0.139131	0	0
RPL8	6132	broad.mit.edu	37	8	146016869	146016869	+	Missense_Mutation	SNP	T	C	C	rs11539893	byFrequency	TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr8:146016869T>C	uc003zeb.2	-	4	403	c.292A>G	c.(292-294)ATT>GTT	p.I98V	RPL8_uc003zdz.2_RNA|RPL8_uc003zea.2_Missense_Mutation_p.I62V|RPL8_uc003zec.2_Missense_Mutation_p.I98V|RPL8_uc010mgc.2_3'UTR	NM_033301	NP_150644	P62917	RL8_HUMAN	ribosomal protein L8	98					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		ACATTGCCAATGTTGAGCTGG	0.607000													3	33					0	0	0.115264	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr9:20414340G>A	uc003zoe.2	-	5	763	c.504C>T	c.(502-504)AGC>AGT	p.S168S	MLLT3_uc011lne.1_Silent_p.S136S|MLLT3_uc011lnf.1_Silent_p.S165S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.A130V	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.144000			T	MLL	ALL								6	65					0	0	0.021553	0	0
FAM75A6	389730	broad.mit.edu	37	9	43626666	43626666	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr9:43626666G>A	uc011lrb.1	-	4	2050	c.2021C>T	c.(2020-2022)ACC>ATC	p.T674I		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	674						integral to membrane					0						ATTTTGTGGGGTCTCACCCAG	0.542000													100	98					0	0	0.139131	0	0
Unknown	0	broad.mit.edu	37	9	78953204	78953204	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr9:78953204T>C	uc004akc.1	+	7	1202	c.982T>C	c.(982-984)TGC>CGC	p.C328R						Homo sapiens cDNA FLJ16215 fis, clone CTONG2025610, moderately similar to PC6B.																		CTGCAAGGGGTGCCAGGGCCC	0.522000													10	20					0	0	0.080935	0	0
HNRNPK	3190	broad.mit.edu	37	9	86587099	86587099	+	Silent	SNP	G	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr9:86587099G>T	uc004ang.3	-	11	875	c.651C>A	c.(649-651)CCC>CCA	p.P217P	HNRNPK_uc011lsw.1_5'UTR|HNRNPK_uc004and.3_5'UTR|HNRNPK_uc004ank.3_Silent_p.P217P|HNRNPK_uc004anf.3_Silent_p.P217P|HNRNPK_uc004anh.3_Silent_p.P193P|HNRNPK_uc011lsx.1_Silent_p.P193P|HNRNPK_uc004ani.3_Silent_p.P217P|HNRNPK_uc004anj.3_Silent_p.P217P|HNRNPK_uc004ann.3_Silent_p.P193P|HNRNPK_uc004anl.3_Silent_p.P217P|HNRNPK_uc004anm.3_Silent_p.P217P|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	217	5 X 4 AA repeats of G-X-G-G.|Necessary for interaction with DDX1.|2 X 22 AA approximate repeats.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GTCCTTTGATGGGAGACTAAA	0.403000													32	34					1.74807e-11	1.98644e-11	0.045705	1	0
SNAPC4	6621	broad.mit.edu	37	9	139272475	139272475	+	Silent	SNP	G	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr9:139272475G>T	uc004chh.2	-	21	3813	c.3804C>A	c.(3802-3804)GCC>GCA	p.A1268A		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	1268					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CCAGGTCCAGGGCCCCCTTCT	0.731000													8	16					5.18039e-06	5.51105e-06	0.038147	1	0
BCOR	54880	broad.mit.edu	37	X	39932880	39932880	+	Silent	SNP	G	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chrX:39932880G>T	uc004den.3	-	4	2011	c.1719C>A	c.(1717-1719)GCC>GCA	p.A573A	BCOR_uc004dep.3_Silent_p.A573A|BCOR_uc004deo.3_Silent_p.A573A|BCOR_uc004dem.3_Silent_p.A573A|BCOR_uc004deq.3_Silent_p.A573A	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	573					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TGGCATTGGGGGCGGGTGATG	0.617000													28	5					5.61819e-17	6.60963e-17	0.108266	1	0
CXorf38	159013	broad.mit.edu	37	X	40506303	40506303	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chrX:40506303A>G	uc004dew.2	-	2	312	c.307T>C	c.(307-309)TGC>CGC	p.C103R	CXorf38_uc011mko.1_Intron|CXorf38_uc004dev.1_5'UTR|CXorf38_uc010nhd.2_RNA	NM_144970	NP_659407	Q8TB03	CX038_HUMAN	hypothetical protein LOC159013	103										ovary(1)	1						CCCGGCCGGCAGTTTCCCCAG	0.622000													14	7					0	0	0.105934	0	0
GJB1	2705	broad.mit.edu	37	X	70444364	70444364	+	Silent	SNP	C	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chrX:70444364C>T	uc004dzf.3	+	2	902	c.807C>T	c.(805-807)ACC>ACT	p.T269T	BCYRN1_uc011mpt.1_Intron|GJB1_uc004dzg.3_Silent_p.T269T	NM_001097642	NP_001091111	P08034	CXB1_HUMAN	gap junction protein, beta 1, 32kDa	269	Cytoplasmic (Probable).				cell-cell signaling|cellular membrane organization|gap junction assembly|nervous system development	connexon complex|endoplasmic reticulum membrane|integral to membrane	gap junction channel activity			breast(1)	1	Renal(35;0.156)					GCCCTGGCACCGGGGCTGGGC	0.637000													5	3					0	0	0.029380	0	0
FBXO42	54455	broad.mit.edu	37	1	16577319	16577320	+	Frame_Shift_Ins	INS	-	TATTAAA	TATTAAA			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:16577319_16577320insTATTAAA	uc001ayg.2	-	10	2215_2216	c.1999_2000insTTTAATA	c.(1999-2001)AGCfs	p.S667fs	FBXO42_uc001aye.3_Frame_Shift_Ins_p.S385fs|FBXO42_uc001ayf.2_Frame_Shift_Ins_p.S574fs	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	667										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		CACAGAACTGCTATTAAATACT	0.475													30	198	---	---	---	---					
ASAP3	55616	broad.mit.edu	37	1	23779230	23779231	+	Frame_Shift_Ins	INS	-	GG	GG			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:23779230_23779231insGG	uc001bha.2	-	4	506_507	c.382_383insCC	c.(382-384)CTGfs	p.L128fs	ASAP3_uc010odz.1_5'UTR|ASAP3_uc010oea.1_Frame_Shift_Ins_p.L128fs|ASAP3_uc001bhc.1_Frame_Shift_Ins_p.L128fs	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	128					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CAGACTGTCCAGGGGGAAAGAG	0.559													80	133	---	---	---	---					
CCDC18	343099	broad.mit.edu	37	1	93680444	93680444	+	Frame_Shift_Del	DEL	C	-	-			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:93680444delC	uc001dpq.2	+	12	2162	c.1994delC	c.(1993-1995)GCTfs	p.A665fs	CCDC18_uc009wdl.1_Frame_Shift_Del_p.A226fs	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	546	Potential.							p.A665T(1)		ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GTTAACATGGCTCACAGAACT	0.388													11	22	---	---	---	---					
RPTN	126638	broad.mit.edu	37	1	152127881	152127884	+	Frame_Shift_Del	DEL	TGTC	-	-			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr1:152127881_152127884delTGTC	uc001ezs.1	-	3	1756_1759	c.1691_1694delGACA	c.(1690-1695)AGACAAfs	p.R564fs		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	564_565	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						GCTCTGGCCTTGTCTGTCTGTCTG	0.485													7	791	---	---	---	---					
HECTD2	143279	broad.mit.edu	37	10	93252242	93252243	+	Splice_Site	INS	-	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr10:93252242_93252243insT	uc001khl.2	+	13	1532	c.1432_splice	c.e13+1	p.G478_splice	LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Splice_Site_p.G482_splice|HECTD2_uc001khm.2_Splice_Site|HECTD2_uc009xty.1_Splice_Site_p.G67_splice|HECTD2_uc001khn.1_Splice_Site_p.G128_splice	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						CCAGATTATGGTAAGTATGTAA	0.312													14	23	---	---	---	---					
STK24	8428	broad.mit.edu	37	13	99114124	99114125	+	Frame_Shift_Ins	INS	-	C	C			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr13:99114124_99114125insC	uc001vnm.1	-	8	1227_1228	c.992_993insG	c.(991-993)GGCfs	p.G331fs	STK24_uc001vnn.1_Frame_Shift_Ins_p.G319fs|STK24_uc010tim.1_Frame_Shift_Ins_p.G300fs	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	331					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CAGAATCACTGCCCCCCGAGGC	0.535													41	71	---	---	---	---					
ACMSD	130013	broad.mit.edu	37	2	135659397	135659398	+	Frame_Shift_Ins	INS	-	T	T			TCGA-A4-8310-01A-11D-2396-08	TCGA-A4-8310-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6aaac72-5533-41b0-8bdb-8639f0339dd0	d8660b1d-6a91-4944-9e79-5911f80f873e	g.chr2:135659397_135659398insT	uc002ttz.2	+	10	1045_1046	c.978_979insT	c.(976-981)GCATTTfs	p.A326fs	ACMSD_uc002tua.2_Frame_Shift_Ins_p.A268fs|uc010zbe.1_Intron	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	326_327					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		ATGCCCTGGCATTTTTGGGTCT	0.297													18	25	---	---	---	---					
