Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SDF4	51150	broad.mit.edu	37	1	1153925	1153925	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:1153925G>A	uc001adh.3	-	6	1154	c.825C>T	c.(823-825)GAC>GAT	p.D275D	SDF4_uc001adg.2_RNA|SDF4_uc001adi.3_Silent_p.D275D|SDF4_uc009vjv.2_Silent_p.D153D|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	275					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		CCCAGTTGTCGTCAATGTCCT	0.607000													8	173					0	0	0.004482	0	0
CCNL2	81669	broad.mit.edu	37	1	1334456	1334456	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:1334456G>A	uc001afi.2	-	1	263	c.231C>T	c.(229-231)CTC>CTT	p.L77L	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Silent_p.L77L|CCNL2_uc001afj.2_Silent_p.L77L|CCNL2_uc001afk.2_Silent_p.L77L|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	77					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CCACCACGCGGAGGTCGGTCT	0.692000													17	34					0	0	0.016522	0	0
CCNL2	81669	broad.mit.edu	37	1	1334592	1334592	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:1334592G>A	uc001afi.2	-	1	127	c.95C>T	c.(94-96)TCG>TTG	p.S32L	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Missense_Mutation_p.S32L|CCNL2_uc001afj.2_Missense_Mutation_p.S32L|CCNL2_uc001afk.2_Missense_Mutation_p.S32L|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	32					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CACCCCCTGCGACCCTGAGGG	0.607000													28	34					0	0	0.010818	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6528353	6528353	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:6528353C>T	uc001ano.1	-	21	2812	c.2711G>A	c.(2710-2712)CGA>CAA	p.R904Q	PLEKHG5_uc001ann.1_Missense_Mutation_p.R885Q|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Missense_Mutation_p.R925Q|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Missense_Mutation_p.R409Q|PLEKHG5_uc009vma.1_Missense_Mutation_p.R688Q|PLEKHG5_uc010nzr.1_Missense_Mutation_p.R917Q|PLEKHG5_uc001ank.1_Missense_Mutation_p.R848Q|PLEKHG5_uc009vmb.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anl.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anm.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anr.1_Missense_Mutation_p.R111Q	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	904					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GGAAGGAACTCGTGGGGACTC	0.662000													9	12					0	0	0.004482	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854436	12854436	+	Silent	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:12854436G>C	uc001auj.1	+	3	763	c.660G>C	c.(658-660)CTG>CTC	p.L220L		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	220											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCACGTCTGATAAGAAAGC	0.393000													336	339					0	0	0.014410	0	0
THRAP3	9967	broad.mit.edu	37	1	36748232	36748232	+	Missense_Mutation	SNP	G	A	A	rs148045717		TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:36748232G>A	uc001cae.3	+	3	292	c.68G>A	c.(67-69)CGT>CAT	p.R23H	THRAP3_uc001caf.3_Missense_Mutation_p.R23H|THRAP3_uc001cag.1_Missense_Mutation_p.R23H	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	23	Arg-rich.|Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCAAGATCTCGTTCTCGTTCA	0.453000			T	USP6	aneurysmal bone cysts								77	86					0	0	0.014410	0	0
MACF1	23499	broad.mit.edu	37	1	39910503	39910503	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:39910503G>C	uc010oiu.1	+	45	15061	c.14930G>C	c.(14929-14931)AGA>ACA	p.R4977T	MACF1_uc010ois.1_Missense_Mutation_p.R4475T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6542	Spectrin 14.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATGGAAGAAAGAAAGGTACAG	0.418000													33	32					0	0	0.015359	0	0
MAST2	23139	broad.mit.edu	37	1	46494445	46494445	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:46494445C>T	uc001cov.2	+	18	2341	c.2058C>T	c.(2056-2058)TGC>TGT	p.C686C	MAST2_uc001cow.2_Silent_p.C686C|MAST2_uc001coy.1_Silent_p.C360C|MAST2_uc001coz.1_Silent_p.C571C|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	686	Protein kinase.				regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CCCAGGTATGCGGGACCCCAG	0.597000													5	234					0	0	0.001984	0	0
ST7L	54879	broad.mit.edu	37	1	113126670	113126670	+	Silent	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:113126670T>C	uc001ecd.2	-	7	1085	c.780A>G	c.(778-780)GCA>GCG	p.A260A	ST7L_uc009wgh.2_Intron|ST7L_uc001ecc.2_Silent_p.A77A|ST7L_uc010owg.1_Silent_p.A195A|ST7L_uc010owh.1_Intron|ST7L_uc001ece.2_Silent_p.A260A|ST7L_uc001ecf.2_Silent_p.A243A|ST7L_uc001ecg.2_RNA|ST7L_uc010owi.1_Silent_p.A195A|ST7L_uc001ech.2_Silent_p.A243A|ST7L_uc001eci.2_Silent_p.A260A|ST7L_uc009wgi.1_RNA|ST7L_uc010owj.1_Silent_p.A243A	NM_017744	NP_060214	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7-like isoform 1	260					negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGCCTTGAGTGCCTGTTTAA	0.433000													75	75					0	0	0.014410	0	0
ATP1A1	476	broad.mit.edu	37	1	116931284	116931284	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:116931284G>A	uc001ege.2	+	6	865	c.526G>A	c.(526-528)GAG>AAG	p.E176K	ATP1A1_uc010owv.1_Missense_Mutation_p.E145K|ATP1A1_uc010oww.1_Missense_Mutation_p.E176K|ATP1A1_uc010owx.1_Missense_Mutation_p.E145K	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	176	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TCGAAATGGTGAGAAAATGAG	0.398000													86	115					0	0	0.014410	0	0
LOC200030	200030	broad.mit.edu	37	1	148025786	148025786	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:148025786G>A	uc001eqf.2	-	7	1101	c.1066C>T	c.(1066-1068)CAG>TAG	p.Q356*	LOC200030_uc001eqe.2_5'UTR|LOC200030_uc001eqg.2_5'UTR|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Nonsense_Mutation_p.Q16*|NBPF14_uc001eqs.1_5'Flank	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	356	Potential.					cytoplasm					0						TGCTTGAGCTGCTCTGCAAGC	0.527000													85	319					0	0	0.014410	0	0
LOC200030	200030	broad.mit.edu	37	1	148025829	148025829	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:148025829C>T	uc001eqf.2	-	7	1058	c.1023G>A	c.(1021-1023)ATG>ATA	p.M341I	LOC200030_uc001eqe.2_5'UTR|LOC200030_uc001eqg.2_5'UTR|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Missense_Mutation_p.M1I|NBPF14_uc001eqs.1_5'Flank	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	341	Potential.					cytoplasm					0						CATTCCTCAGCATAGATTTTA	0.532000													131	466					0	0	0.014410	0	0
SHE	126669	broad.mit.edu	37	1	154474217	154474217	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:154474217C>T	uc001ffb.2	-	1	373	c.286G>A	c.(286-288)GTC>ATC	p.V96I	SHE_uc001ffc.2_RNA|TDRD10_uc001ffd.2_5'Flank|TDRD10_uc009wow.2_5'Flank	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	96										breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TTGGGGCCGACGCCGGCCCTG	0.731000													4	3					0	0	0.004482	0	0
TDRD10	126668	broad.mit.edu	37	1	154493835	154493835	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:154493835G>A	uc009wow.2	+	6	1087	c.249G>A	c.(247-249)GTG>GTA	p.V83V	TDRD10_uc001ffd.2_Silent_p.V83V|TDRD10_uc001ffe.2_Silent_p.V4V	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	83	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGCAGAAAGTGACACTTGCAA	0.502000													58	331					0	0	0.014410	0	0
XPR1	9213	broad.mit.edu	37	1	180849312	180849312	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:180849312G>C	uc001goi.2	+	14	2101	c.1909G>C	c.(1909-1911)GAT>CAT	p.D637H	XPR1_uc009wxn.2_Missense_Mutation_p.D572H	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	637	EXS.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						CCTGAACGCAGATGATCAGAC	0.517000													45	65					0	0	0.014410	0	0
LRRN2	10446	broad.mit.edu	37	1	204587907	204587907	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:204587907C>T	uc001hbe.1	-	3	1602	c.1214G>A	c.(1213-1215)CGC>CAC	p.R405H	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.R405H|LRRN2_uc009xbf.1_Missense_Mutation_p.R405H|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	405	Extracellular (Potential).|LRRCT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GACCGGGAGGCGCTGGAGGTC	0.662000													7	78					0	0	0.008291	0	0
SLC26A9	115019	broad.mit.edu	37	1	205888030	205888030	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:205888030C>T	uc001hdq.2	-	19	2308	c.2194G>A	c.(2194-2196)GAC>AAC	p.D732N	SLC26A9_uc001hdm.2_5'Flank|SLC26A9_uc001hdn.2_5'Flank|SLC26A9_uc001hdo.2_Missense_Mutation_p.D400N|SLC26A9_uc001hdp.2_Missense_Mutation_p.D732N	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	732	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGGACTGCGTCATGTATGCTG	0.517000											OREG0014164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	288	347					0	0	0.014410	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49667829	49667829	+	Missense_Mutation	SNP	C	T	T	rs75710233	byFrequency	TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr10:49667829C>T	uc001jgt.2	-	5	854	c.557G>A	c.(556-558)CGC>CAC	p.R186H	ARHGAP22_uc001jgs.2_Missense_Mutation_p.R96H|ARHGAP22_uc001jgu.2_Missense_Mutation_p.R202H|ARHGAP22_uc010qgl.1_Missense_Mutation_p.R143H|ARHGAP22_uc010qgm.1_Missense_Mutation_p.R192H|ARHGAP22_uc001jgv.2_5'UTR	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	186	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						AGTGAGCCCGCGCTCCCGGAT	0.642000													66	152					0	0	0.014410	0	0
SGMS1	259230	broad.mit.edu	37	10	52071078	52071078	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr10:52071078T>C	uc001jje.2	-	9	1793	c.839A>G	c.(838-840)TAT>TGT	p.Y280C	SGMS1_uc010qhk.1_Missense_Mutation_p.Y111C|SGMS1_uc009xot.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	286	Helical; (Potential).				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						GCTGTACAGATAGTCCCCACA	0.453000													27	39					0	0	0.007291	0	0
IDE	3416	broad.mit.edu	37	10	94297234	94297234	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr10:94297234G>C	uc001kia.2	-	2	248	c.172C>G	c.(172-174)CCT>GCT	p.P58A		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	58					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTCTTCAGGAGACTTGGTA	0.388000													108	114					0	0	0.014410	0	0
RIC8A	60626	broad.mit.edu	37	11	209483	209483	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:209483T>A	uc001log.2	+	3	534	c.209T>A	c.(208-210)GTC>GAC	p.V70D	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Missense_Mutation_p.V70D|RIC8A_uc001loh.2_Missense_Mutation_p.V63D	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	70						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTGCAGAGTGTCCGAATCCTG	0.642000													33	109					0	0	0.009718	0	0
APLNR	187	broad.mit.edu	37	11	57004337	57004337	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:57004337G>C	uc001njo.2	-	1	591	c.142C>G	c.(142-144)CTG>GTG	p.L48V	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	48	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						CAGAGCACCAGACCGTTGCCC	0.592000													71	105					0	0	0.014410	0	0
MS4A15	219995	broad.mit.edu	37	11	60540926	60540926	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:60540926T>A	uc009ynf.1	+	5	687	c.467T>A	c.(466-468)ATT>AAT	p.I156N	MS4A15_uc001npx.2_Missense_Mutation_p.I63N|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Missense_Mutation_p.I115N	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	156	Helical; (Potential).					integral to membrane	receptor activity			lung(1)	1						GGGACAGCCATTCTGCTCATG	0.572000													27	22					0	0	0.019004	0	0
VWCE	220001	broad.mit.edu	37	11	61026184	61026184	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:61026184G>A	uc001nra.2	-	20	3110	c.2831C>T	c.(2830-2832)CCA>CTA	p.P944L	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	944						extracellular region	calcium ion binding			ovary(1)	1						AGCCCCCACTGGGGGCTGCTG	0.662000													41	164					0	0	0.014410	0	0
STARD10	10809	broad.mit.edu	37	11	72470333	72470333	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:72470333C>G	uc001osy.2	-	3	592	c.301G>C	c.(301-303)GAG>CAG	p.E101Q	ARAP1_uc001osv.2_Intron|STARD10_uc001osz.3_Missense_Mutation_p.E101Q|STARD10_uc001ota.2_Missense_Mutation_p.E55Q|STARD10_uc001otb.2_Missense_Mutation_p.E101Q	NM_006645	NP_006636	Q9Y365	PCTL_HUMAN	START domain containing 10	101	START.										0			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			TCAAAAGTCTCAATGACGTTG	0.562000													47	70					0	0	0.014410	0	0
ARRB1	408	broad.mit.edu	37	11	74985127	74985127	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:74985127G>C	uc001owe.1	-	11	1127	c.905C>G	c.(904-906)TCT>TGT	p.S302C	ARRB1_uc001owf.1_Missense_Mutation_p.S302C	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	302					G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						CAGGGTGCTAGAGGCCAAGTT	0.602000													180	212					0	0	0.014410	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48142257	48142257	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr12:48142257G>A	uc009zkp.2	-	11	1537	c.1097C>T	c.(1096-1098)TCC>TTC	p.S366F	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Missense_Mutation_p.S366F|RAPGEF3_uc001rpz.3_Missense_Mutation_p.S408F|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Missense_Mutation_p.S420F	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	366					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		ATGAGCACTGGAATCTGGTCC	0.478000													42	57					0	0	0.014410	0	0
MLL2	8085	broad.mit.edu	37	12	49425839	49425839	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr12:49425839G>A	uc001rta.3	-	39	12649	c.12649C>T	c.(12649-12651)CAG>TAG	p.Q4217*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4217	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGCTGCTGCTGAGGACTTAAG	0.622000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			22	40					0	0	0.012213	0	0
MLL2	8085	broad.mit.edu	37	12	49426526	49426526	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr12:49426526G>A	uc001rta.3	-	39	11962	c.11962C>T	c.(11962-11964)CAG>TAG	p.Q3988*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3988	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGTTGTTGCTGAGGAGACAGT	0.378000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			16	11					0	0	0.024245	0	0
HSP90B1	7184	broad.mit.edu	37	12	104327895	104327895	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr12:104327895G>C	uc001tkb.1	+	5	678	c.573G>C	c.(571-573)TTG>TTC	p.L191F	HSP90B1_uc010swg.1_Intron|HSP90B1_uc009zui.1_Missense_Mutation_p.L191F	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	191					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CTTCTGAATTGATTGGCCAGT	0.428000													6	190					0	0	0.006214	0	0
UCHL3	7347	broad.mit.edu	37	13	76123978	76123978	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr13:76123978C>G	uc001vjq.2	+	1	52	c.22C>G	c.(22-24)CCG>GCG	p.P8A		NM_006002	NP_005993	P15374	UCHL3_HUMAN	ubiquitin carboxyl-terminal esterase L3	8	Interaction with ubiquitin.				ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity				0				GBM - Glioblastoma multiforme(99;0.0125)		ACGCTGGCTGCCGCTGGAGGC	0.607000											OREG0022446	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	53					0	0	0.004990	0	0
INSM2	84684	broad.mit.edu	37	14	36005048	36005048	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:36005048C>T	uc001wth.1	+	1	1801	c.1590C>T	c.(1588-1590)TGC>TGT	p.C530C		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	530	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		GCAAGCACTGCCCGTCCACTT	0.627000													21	102					0	0	0.010504	0	0
FKBP3	2287	broad.mit.edu	37	14	45603575	45603575	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:45603575G>A	uc010tqf.1	-	1	158	c.85C>T	c.(85-87)CTG>TTG	p.L29L	FANCM_uc001wwc.2_5'Flank|FANCM_uc001wwd.3_5'Flank|FANCM_uc010anf.2_5'Flank	NM_002013	NP_002004	Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	29					protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity				0						TGTTCCTGCAGAAACTTGATA	0.652000													80	110					0	0	0.014410	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256349	69256349	+	Silent	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:69256349C>G	uc001xkh.1	-	2	1048	c.918G>C	c.(916-918)CTG>CTC	p.L306L	ZFP36L1_uc001xki.1_Silent_p.L306L	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	306					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TGGAGCTGCTCAGGTAGCCCT	0.597000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	89	124					0	0	0.014410	0	0
MLH3	27030	broad.mit.edu	37	14	75514890	75514890	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:75514890G>C	uc001xrd.1	-	2	1685	c.1469C>G	c.(1468-1470)TCT>TGT	p.S490C	MLH3_uc001xre.1_Missense_Mutation_p.S490C|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	490					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TTCCAGGAAAGATTTTTTATG	0.378000								MMR					60	93					0	0	0.014410	0	0
PPP2R5C	5527	broad.mit.edu	37	14	102391505	102391505	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:102391505C>G	uc001yko.2	+	14	1611	c.1471C>G	c.(1471-1473)CCT>GCT	p.P491A	PPP2R5C_uc010txr.1_Missense_Mutation_p.P522A|PPP2R5C_uc001ykk.2_Missense_Mutation_p.P507A|PPP2R5C_uc001ykp.2_Missense_Mutation_p.P452A	NM_002719	NP_002710	Q13362	2A5G_HUMAN	gamma isoform of regulatory subunit B56, protein	491					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity			ovary(1)|breast(1)	2						GAAGGACCGTCCTCTTGCACG	0.552000													7	474					0	0	0.004482	0	0
SNORD116-1	100033413	broad.mit.edu	37	15	25296712	25296712	+	RNA	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:25296712G>C	uc001yxg.2	+	1		c.90G>C				NR_003316				Homo sapiens small nucleolar RNA, C/D box 116-1 (SNORD116-1), non-coding RNA.												0						CATCGGAACTGAGGTCCAGCA	0.473000													83	132					0	0	0.014410	0	0
GABRB3	2562	broad.mit.edu	37	15	26793190	26793190	+	Nonsense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:26793190G>C	uc001zaz.2	-	9	1314	c.1172C>G	c.(1171-1173)TCA>TGA	p.S391*	GABRB3_uc010uae.1_Nonsense_Mutation_p.S306*|GABRB3_uc001zba.2_Nonsense_Mutation_p.S391*|GABRB3_uc001zbb.2_Nonsense_Mutation_p.S447*	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	391	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGATATTGCTGAATTCCTGGT	0.493000													98	128					0	0	0.014410	0	0
APBA2	321	broad.mit.edu	37	15	29368274	29368274	+	Nonsense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:29368274C>A	uc001zck.2	+	5	1256	c.1049C>A	c.(1048-1050)TCA>TAA	p.S350*	APBA2_uc010azj.2_Nonsense_Mutation_p.S350*|APBA2_uc010uat.1_Nonsense_Mutation_p.S350*|APBA2_uc001zcl.2_Nonsense_Mutation_p.S350*|APBA2_uc001zcm.1_Nonsense_Mutation_p.S54*	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	350					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		AAGGTGGCATCATTTCCAAGT	0.373000													9	322					0.00185496	0.00202925	0.016723	1	0
TYRO3	7301	broad.mit.edu	37	15	41859568	41859568	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:41859568C>A	uc001zof.1	+	7	1018	c.794C>A	c.(793-795)GCC>GAC	p.A265D		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	265	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.A265G(1)		ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GTGACACAGGCCCCAGGAGGC	0.557000													8	250					0.00448238	0.00487085	0.004482	1	0
DMXL2	23312	broad.mit.edu	37	15	51857284	51857284	+	Splice_Site	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:51857284C>A	uc002abf.2	-	4	589	c.364_splice	c.e4+1	p.D122_splice	DMXL2_uc010ufy.1_Splice_Site_p.D122_splice|DMXL2_uc010bfa.2_Splice_Site_p.D122_splice	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2							cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TTGCTAAATACCTTGAGGATC	0.289000													6	9					3.59834e-05	3.98999e-05	0.021553	1	0
LOC645752	645752	broad.mit.edu	37	15	78211648	78211648	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:78211648A>G	uc010bky.2	-	11	883	c.119T>C	c.(118-120)CTA>CCA	p.L40P		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						CGCCAGGGATAGGGGCTCAGC	0.522000													4	96					0	0	0.014758	0	0
MCTP2	55784	broad.mit.edu	37	15	95019963	95019963	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:95019963T>C	uc002btj.2	+	21	2574	c.2509T>C	c.(2509-2511)TCC>CCC	p.S837P	MCTP2_uc010boj.2_Missense_Mutation_p.S566P|MCTP2_uc010bok.2_Missense_Mutation_p.S782P|MCTP2_uc002btl.2_Missense_Mutation_p.S425P	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	837					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAATCCCTATTCCATCGACAA	0.323000													6	187					0	0	0.001984	0	0
MCTP2	55784	broad.mit.edu	37	15	95019965	95019965	+	Silent	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:95019965C>A	uc002btj.2	+	21	2576	c.2511C>A	c.(2509-2511)TCC>TCA	p.S837S	MCTP2_uc010boj.2_Silent_p.S566S|MCTP2_uc010bok.2_Silent_p.S782S|MCTP2_uc002btl.2_Silent_p.S425S	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	837					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			ATCCCTATTCCATCGACAATA	0.323000													6	192					2.0095e-06	2.25895e-06	0.001984	1	0
SYNM	23336	broad.mit.edu	37	15	99670884	99670884	+	Silent	SNP	C	G	G	rs112125623		TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:99670884C>G	uc002bup.2	+	6	2439	c.2319C>G	c.(2317-2319)GTC>GTG	p.V773V	SYNM_uc002buo.2_Silent_p.V773V|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	773	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						TGGAGGAGGTCGAAGATGTGT	0.547000													3	65					0	0	0.004672	0	0
GGA2	23062	broad.mit.edu	37	16	23503028	23503028	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:23503028G>C	uc002dlq.2	-	5	521	c.445C>G	c.(445-447)CGA>GGA	p.R149G	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	149	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		TAAGCGTCTCGAATCTTGATG	0.353000													8	367					0	0	0.006214	0	0
CCDC102A	92922	broad.mit.edu	37	16	57552177	57552177	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:57552177G>C	uc002elw.2	-	6	1264	c.1051C>G	c.(1051-1053)CAG>GAG	p.Q351E		NM_033212	NP_149989	Q96A19	C102A_HUMAN	coiled-coil domain containing 102A	351	Potential.									ovary(1)	1						TTTTCGGCCTGCAGCCGCTCC	0.682000													7	45					0	0	0.023175	0	0
WDR59	79726	broad.mit.edu	37	16	74990405	74990405	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:74990405G>A	uc002fdh.1	-	3	310	c.208C>T	c.(208-210)CAT>TAT	p.H70Y	WDR59_uc002fdi.2_Missense_Mutation_p.H70Y|WDR59_uc002fdj.2_Missense_Mutation_p.H70Y	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	70	WD 1.									ovary(1)|breast(1)	2						AAGCTGTCATGAGGATTCCAC	0.468000													54	76					0	0	0.014410	0	0
ZDHHC7	55625	broad.mit.edu	37	16	85010706	85010706	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:85010706C>T	uc002fiq.2	-	7	1098	c.745G>A	c.(745-747)GAG>AAG	p.E249K	ZDHHC7_uc010voi.1_Missense_Mutation_p.E286K|ZDHHC7_uc002fir.1_RNA	NM_017740	NP_060210	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7 isoform 2	249						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(1)	1						CTTACCGTCTCGTCGTTGCAT	0.448000													128	156					0	0	0.014410	0	0
ITGAE	3682	broad.mit.edu	37	17	3659152	3659152	+	Missense_Mutation	SNP	A	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:3659152A>T	uc002fwo.3	-	11	1310	c.1211T>A	c.(1210-1212)ATT>AAT	p.I404N		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	404	FG-GAP 3.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		ACTGAAGCCAATCTGTGCCAG	0.592000													3	12					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7579415	7579415	+	Nonsense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:7579415C>T	uc002gim.2	-	4	466	c.272G>A	c.(271-273)TGG>TAG	p.W91*	TP53_uc002gig.1_Nonsense_Mutation_p.W91*|TP53_uc002gih.2_Nonsense_Mutation_p.W91*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.W91*|TP53_uc010cni.1_Nonsense_Mutation_p.W91*|TP53_uc002gij.2_Nonsense_Mutation_p.W91*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.W52*|TP53_uc010cnk.1_Nonsense_Mutation_p.W106*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	91	Interaction with WWOX.		W -> C (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W91*(11)|p.0?(7)|p.G59fs*23(3)|p.V73fs*9(1)|p.D48fs*55(1)|p.W91fs*57(1)|p.A88fs*52(1)|p.W91fs*13(1)|p.P87fs*54(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGACAGGGGCCAGGAGGGGGC	0.632000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	134					0	0	0.008871	0	0
MYH13	8735	broad.mit.edu	37	17	10216500	10216500	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:10216500G>A	uc002gmk.1	-	30	4246	c.4156C>T	c.(4156-4158)CGC>TGC	p.R1386C		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1386	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCCTCTGTGCGCTGAATGGCG	0.617000													8	341					0	0	0.008291	0	0
KRT13	3860	broad.mit.edu	37	17	39659037	39659037	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:39659037T>A	uc002hwu.1	-	5	988	c.925A>T	c.(925-927)ACC>TCC	p.T309S	KRT13_uc002hwv.1_Missense_Mutation_p.T309S|KRT13_uc002hww.2_Missense_Mutation_p.T202S|KRT13_uc010wfr.1_Missense_Mutation_p.T202S|KRT13_uc010cxo.2_Missense_Mutation_p.T309S|KRT13_uc002hwx.1_Missense_Mutation_p.T297S	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	309	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GCAGTGTTGGTAGACACCTCC	0.577000													212	254					0	0	0.014410	0	0
DBF4B	80174	broad.mit.edu	37	17	42828063	42828063	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:42828063C>T	uc002ihf.2	+	14	1503	c.1290C>T	c.(1288-1290)CTC>CTT	p.L430L	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	430					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				CCACAACCCTCCTGCCGGCCT	0.617000													59	80					0	0	0.014410	0	0
EPN3	55040	broad.mit.edu	37	17	48615544	48615544	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:48615544G>A	uc002ira.3	+	3	1102	c.667G>A	c.(667-669)GAG>AAG	p.E223K	EPN3_uc010wms.1_Missense_Mutation_p.E278K|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.E223K	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	223	UIM 1.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CATGAGCCGTGAGGAGGCAGA	0.667000													16	23					0	0	0.016522	0	0
EPN3	55040	broad.mit.edu	37	17	48616322	48616322	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:48616322G>C	uc002ira.3	+	4	1194	c.759G>C	c.(757-759)GAG>GAC	p.E253D	EPN3_uc010wms.1_Intron|EPN3_uc010wmt.1_Intron|EPN3_uc010wmu.1_Intron	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	253	UIM 2.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AGGAGCACGAGAAGGTAGTGG	0.687000													3	12					0	0	0.014758	0	0
SPATA20	64847	broad.mit.edu	37	17	48628090	48628090	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:48628090G>A	uc002irf.2	+	10	1288	c.1147G>A	c.(1147-1149)GAA>AAA	p.E383K	SPATA20_uc002irc.2_Missense_Mutation_p.E50K|SPATA20_uc002ire.2_Missense_Mutation_p.E339K|SPATA20_uc002ird.2_Missense_Mutation_p.E399K|SPATA20_uc010wmv.1_3'UTR|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	383					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CTATAGCGCAGAAGATGCAGA	0.672000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	168	181					0	0	0.014410	0	0
SPATA20	64847	broad.mit.edu	37	17	48628385	48628385	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:48628385G>A	uc002irf.2	+	11	1503	c.1362G>A	c.(1360-1362)CAG>CAA	p.Q454Q	SPATA20_uc002irc.2_Silent_p.Q121Q|SPATA20_uc002ire.2_Silent_p.Q410Q|SPATA20_uc002ird.2_Silent_p.Q470Q|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	454					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			TGCAGGGCCAGAATGTGCTGA	0.637000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	65					0	0	0.014410	0	0
TEX2	55852	broad.mit.edu	37	17	62238165	62238165	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:62238165C>G	uc002jec.2	-	8	2973	c.2800G>C	c.(2800-2802)GAA>CAA	p.E934Q	TEX2_uc002jed.2_Missense_Mutation_p.E941Q|TEX2_uc002jee.2_Missense_Mutation_p.E934Q	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	934					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CCTTACCCTTCTTTGCCAATT	0.463000													577	239					0	0	0.014410	0	0
CACNG4	27092	broad.mit.edu	37	17	65026963	65026963	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:65026963T>C	uc002jft.1	+	4	842	c.827T>C	c.(826-828)ATG>ACG	p.M276T		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	276	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			GAGCTGTCCATGTACACGCTG	0.647000													36	141					0	0	0.010771	0	0
SLC38A10	124565	broad.mit.edu	37	17	79249777	79249777	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:79249777C>T	uc002jzz.1	-	8	1279	c.904G>A	c.(904-906)GAG>AAG	p.E302K	SLC38A10_uc002jzy.1_Missense_Mutation_p.E220K|SLC38A10_uc002kab.2_Missense_Mutation_p.E302K	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	302					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ACCTGCTGCTCACACAGCAGC	0.597000													81	309					0	0	0.014410	0	0
DSC2	1824	broad.mit.edu	37	18	28660162	28660162	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr18:28660162G>C	uc002kwl.3	-	10	1874	c.1420C>G	c.(1420-1422)CCA>GCA	p.P474A	DSC2_uc002kwk.3_Missense_Mutation_p.P474A	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	474	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GTCTGTATTGGAGGGTTACAC	0.443000													154	125					0	0	0.014410	0	0
C19orf21	126353	broad.mit.edu	37	19	757669	757669	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:757669C>T	uc002lpo.2	+	2	806	c.723C>T	c.(721-723)AAC>AAT	p.N241N		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	241										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTGGCCAACGGGCACGTGG	0.672000													30	24					0	0	0.010818	0	0
SH2D3A	10045	broad.mit.edu	37	19	6755293	6755293	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:6755293C>T	uc002mft.2	-	5	724	c.530G>A	c.(529-531)CGA>CAA	p.R177Q	SH2D3A_uc010xjg.1_Missense_Mutation_p.R55Q	NM_005490	NP_005481	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	177					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2						ACTGCTCGTTCGGGGCAAGGC	0.592000													6	368					0	0	0.001984	0	0
PIK3R2	5296	broad.mit.edu	37	19	18279617	18279617	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:18279617G>A	uc002nia.1	+	15	2402	c.1890G>A	c.(1888-1890)ACG>ACA	p.T630T	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	630	SH2 2.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						TCAACCGCACGCAGGCAGAGG	0.657000											OREG0025359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	30					0	0	0.013726	0	0
LMTK3	114783	broad.mit.edu	37	19	49001422	49001422	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:49001422C>A	uc002pjk.2	-	12	2991	c.2991G>T	c.(2989-2991)AGG>AGT	p.R997S		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		TCTCCTCCCTCCTTGGGGGTG	0.647000													12	295					2.27111e-07	2.58875e-07	0.013537	1	0
LMTK3	114783	broad.mit.edu	37	19	49001524	49001524	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:49001524C>G	uc002pjk.2	-	12	2889	c.2889G>C	c.(2887-2889)CAG>CAC	p.Q963H		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTGGGGCTCTCTGGTCCCCGT	0.647000													6	100					0	0	0.021553	0	0
PRR12	57479	broad.mit.edu	37	19	50099849	50099849	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:50099849G>A	uc002poo.3	+	4	2257	c.2257G>A	c.(2257-2259)GCC>ACC	p.A753T		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CGGGGCAGGCGCCAAGGAGCT	0.692000													11	11					0	0	0.008291	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:53856730G>A	uc010ydv.1	+	4	2919	c.2802G>A	c.(2800-2802)AAG>AAA	p.K934K	ZNF845_uc010ydw.1_Silent_p.K934K	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934	C2H2-type 26.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAATTCATAAGACAATTCATA	0.368000													3	31					0	0	0.009096	0	0
POMC	5443	broad.mit.edu	37	2	25387560	25387560	+	Missense_Mutation	SNP	A	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:25387560A>C	uc002rfy.1	-	3	345	c.82T>G	c.(82-84)TGC>GGC	p.C28G	POMC_uc002rfz.1_Missense_Mutation_p.C28G|POMC_uc002rga.1_Missense_Mutation_p.C28G	NM_001035256	NP_001030333	P01189	COLI_HUMAN	proopiomelanocortin preproprotein	28					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	CTCTCCAGGCACCAGCCACGC	0.617000													9	99					0	0	0.013726	0	0
ETAA1	54465	broad.mit.edu	37	2	67631299	67631299	+	Silent	SNP	A	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:67631299A>G	uc002sdz.1	+	5	1624	c.1485A>G	c.(1483-1485)CAA>CAG	p.Q495Q		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	495						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						ACGAAATTCAAAATTGTATAG	0.279000													4	11					0	0	0.009096	0	0
WDR54	84058	broad.mit.edu	37	2	74652604	74652604	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:74652604A>G	uc002slb.2	+	9	919	c.859A>G	c.(859-861)AGT>GGT	p.S287G		NM_032118	NP_115494	Q9H977	WDR54_HUMAN	WD repeat domain 54	287	WD 4.										0						AAACCCAGAGAGTGGCTACAT	0.597000													3	153					0	0	0.009096	0	0
GGT8P	645367	broad.mit.edu	37	2	91968909	91968909	+	RNA	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:91968909C>T	uc010fho.1	+	2		c.1240C>T				NR_003503				Homo sapiens cDNA FLJ31276 fis, clone KIDNE2006376, weakly similar to GAMMA-GLUTAMYLTRANSPEPTIDASE 1 PRECURSOR (EC 2.3.2.2).												0						GCCACCCACCCGTGACAGGCG	0.642000													3	16					0	0	0.009096	0	0
AFF3	3899	broad.mit.edu	37	2	100623250	100623250	+	Silent	SNP	G	A	A	rs138844530	by1000genomes	TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:100623250G>A	uc002tag.2	-	6	953	c.717C>T	c.(715-717)GAC>GAT	p.D239D	AFF3_uc002taf.2_Silent_p.D264D|AFF3_uc010fiq.1_Silent_p.D239D|AFF3_uc010yvr.1_Silent_p.D393D|AFF3_uc002tah.1_Silent_p.D264D|AFF3_uc010fir.1_Silent_p.D316D|AFF3_uc002tai.2_Silent_p.D161D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	239					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GATCTTGGCCGTCCATTGGCC	0.572000													61	55					0	0	0.014410	0	0
NEB	4703	broad.mit.edu	37	2	152397247	152397247	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:152397247C>T	uc010fnx.2	-	109	15839	c.15648G>A	c.(15646-15648)TTG>TTA	p.L5216L	NEB_uc002txr.2_Silent_p.L1639L	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5216	Nebulin 142.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TAGCATGCTTCAAGGCTGTGG	0.433000													10	87					0	0	0.020292	0	0
IFIH1	64135	broad.mit.edu	37	2	163174420	163174420	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:163174420T>A	uc002uce.2	-	1	620	c.398A>T	c.(397-399)GAC>GTC	p.D133V	IFIH1_uc002ucf.2_Missense_Mutation_p.D133V	NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	133	CARD 2.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						ATCCAAGACGTCTCTAACTAG	0.483000													16	754					0	0	0.028581	0	0
CCDC108	255101	broad.mit.edu	37	2	219886640	219886640	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:219886640C>T	uc002vjl.1	-	18	3076	c.2992G>A	c.(2992-2994)GAG>AAG	p.E998K	CCDC108_uc002vjm.3_5'Flank	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	998						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGGCCAGCTCCTTTTCCTTT	0.597000													120	79					0	0	0.014410	0	0
OBSL1	23363	broad.mit.edu	37	2	220420911	220420911	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:220420911G>A	uc010fwk.2	-	14	4497	c.4440C>T	c.(4438-4440)GCC>GCT	p.A1480A	OBSL1_uc002vmh.1_Silent_p.A379A|OBSL1_uc010zli.1_Silent_p.A287A|OBSL1_uc010fwl.1_Silent_p.A955A	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1480	Ig-like 12.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CCCAGCGCACGGCCCCCGCTG	0.657000													4	13					0	0	0.021553	0	0
CPXM1	56265	broad.mit.edu	37	20	2775058	2775058	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr20:2775058C>A	uc002wgu.2	-	14	2047	c.1983G>T	c.(1981-1983)TGG>TGT	p.W661C	CPXM1_uc010gas.2_Missense_Mutation_p.W587C	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	661					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						TCAGCAGACGCCAATAATCCC	0.597000													17	86					3.62473e-10	4.28139e-10	0.012319	1	0
HNF4A	3172	broad.mit.edu	37	20	43048484	43048484	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr20:43048484C>T	uc002xma.2	+	7	949	c.860C>T	c.(859-861)GCC>GTC	p.A287V	HNF4A_uc002xlt.2_Missense_Mutation_p.A265V|HNF4A_uc002xlu.2_Missense_Mutation_p.A265V|HNF4A_uc002xlv.2_Missense_Mutation_p.A265V|HNF4A_uc002xly.2_Missense_Mutation_p.A287V|HNF4A_uc002xlz.2_Missense_Mutation_p.A287V|HNF4A_uc010ggq.2_Missense_Mutation_p.A280V	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	287					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			AATGAGTATGCCTACCTCAAA	0.557000													5	234					0	0	0.021553	0	0
CTCFL	140690	broad.mit.edu	37	20	56090811	56090811	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr20:56090811C>G	uc010gix.1	-	5	1801	c.1139G>C	c.(1138-1140)AGA>ACA	p.R380T	CTCFL_uc010giw.1_Missense_Mutation_p.R380T|CTCFL_uc002xym.2_Missense_Mutation_p.R380T|CTCFL_uc010giz.1_5'UTR|CTCFL_uc010giy.1_5'UTR|CTCFL_uc010gja.1_Missense_Mutation_p.R380T|CTCFL_uc010gjb.1_Missense_Mutation_p.R380T|CTCFL_uc010gjc.1_Missense_Mutation_p.R380T|CTCFL_uc010gjd.1_Missense_Mutation_p.R380T|CTCFL_uc010gje.2_Missense_Mutation_p.R380T|CTCFL_uc010gjf.2_Missense_Mutation_p.R175T|CTCFL_uc010gjg.2_Missense_Mutation_p.R112T|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Missense_Mutation_p.R175T|CTCFL_uc010gjj.1_Missense_Mutation_p.R380T	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	380	C2H2-type 5.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GTAGGTATCTCTGCTGGCATA	0.483000													226	343					0	0	0.014410	0	0
ZBTB46	140685	broad.mit.edu	37	20	62407208	62407208	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr20:62407208G>A	uc002ygv.1	-	3	1246	c.1045C>T	c.(1045-1047)CTG>TTG	p.L349L	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GGAGGGCCCAGATAGCTGGCT	0.662000													120	128					0	0	0.014410	0	0
C21orf99	149992	broad.mit.edu	37	21	14439254	14439254	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr21:14439254G>A	uc002yja.3	+	10		c.2772G>A				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AGGAAAAATCGAAGAGCAACA	0.303000													15	21					0	0	0.028581	0	0
MB	4151	broad.mit.edu	37	22	36013290	36013290	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:36013290G>A	uc003anz.2	-	1	95	c.15C>T	c.(13-15)GAC>GAT	p.D5D	MB_uc003aoa.2_Silent_p.D5D|MB_uc003aob.2_Silent_p.D5D	NM_005368	NP_005359	P02144	MYG_HUMAN	myoglobin	5							heme binding|oxygen transporter activity				0						GCCATTCCCCGTCGCTGAGCC	0.577000													4	137					0	0	0.001984	0	0
PICK1	9463	broad.mit.edu	37	22	38470965	38470965	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:38470965C>G	uc003auq.2	+	13	1464	c.1074C>G	c.(1072-1074)TTC>TTG	p.F358L	PICK1_uc003aur.2_Missense_Mutation_p.F358L|PICK1_uc003aus.2_Missense_Mutation_p.F358L|PICK1_uc003aut.2_Missense_Mutation_p.F358L	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	358					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					CCGACGTCTTCCCCATCGAGG	0.532000													23	38					0	0	0.024334	0	0
MKL1	57591	broad.mit.edu	37	22	40814967	40814967	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:40814967G>A	uc003ayv.1	-	9	1682	c.1475C>T	c.(1474-1476)TCG>TTG	p.S492L	MKL1_uc003ayw.1_Missense_Mutation_p.S492L|MKL1_uc010gye.1_Missense_Mutation_p.S492L|MKL1_uc010gyf.1_Missense_Mutation_p.S442L	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	492					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity	p.S492S(1)		ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTGCAGTGGCGAGGCCTGCAG	0.677000			T	RBM15	acute megakaryocytic leukemia								18	54					0	0	0.007413	0	0
PARVB	29780	broad.mit.edu	37	22	44564537	44564537	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:44564537C>T	uc003ben.2	+	13	1126	c.1074C>T	c.(1072-1074)ACC>ACT	p.T358T	PARVB_uc003bem.2_Silent_p.T391T|PARVB_uc010gzn.2_Silent_p.T283T|PARVB_uc003beo.2_Silent_p.T321T	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	358	CH 2.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				ACCTGTTCACCAAGTACAAGA	0.552000													8	111					0	0	0.004482	0	0
GTSE1	51512	broad.mit.edu	37	22	46712115	46712115	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:46712115C>T	uc011aqy.1	+	7	1450	c.1238C>T	c.(1237-1239)CCC>CTC	p.P413L	GTSE1_uc011aqz.1_Missense_Mutation_p.P260L|GTSE1_uc003bhl.1_Missense_Mutation_p.P38L|GTSE1_uc003bhm.1_Missense_Mutation_p.P38L	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	394					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CTCACGGCACCCCCCTCAGCA	0.627000													5	133					0	0	0.014758	0	0
CELSR1	9620	broad.mit.edu	37	22	46930992	46930992	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:46930992G>A	uc003bhw.1	-	1	2076	c.2076C>T	c.(2074-2076)TAC>TAT	p.Y692Y		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	692	Extracellular (Potential).|Cadherin 5.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GACGAAGCTCGTAGGTGGGCT	0.642000													12	28					0	0	0.013537	0	0
LHFPL4	375323	broad.mit.edu	37	3	9547649	9547649	+	Splice_Site	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:9547649G>A	uc003bry.2	-	3	929	c.643_splice	c.e3+1	p.D215_splice		NM_198560	NP_940962	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4							integral to membrane				ovary(2)|skin(1)	3	Medulloblastoma(99;0.227)					CAGCACACTCGCCTTTGTTCT	0.592000													176	173					0	0	0.014410	0	0
EFHB	151651	broad.mit.edu	37	3	19925989	19925989	+	Silent	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:19925989G>C	uc003cbl.3	-	11	2248	c.2052C>G	c.(2050-2052)CTC>CTG	p.L684L	EFHB_uc003cbm.2_Silent_p.L554L	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	684					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						GAAGTGTCCGGAGAGTCTTTT	0.393000													64	90					0	0	0.014410	0	0
COL6A6	131873	broad.mit.edu	37	3	130287049	130287049	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:130287049G>A	uc010htl.2	+	5	2033	c.2002G>A	c.(2002-2004)GAC>AAC	p.D668N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	668	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CCAGTTCAGCGACATCAATAA	0.423000													114	153					0	0	0.014410	0	0
ZNF876P	642280	broad.mit.edu	37	4	247622	247622	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:247622G>A	uc010iba.2	+	2		c.456G>A				NR_027481				Homo sapiens cDNA clone IMAGE:4828836.												0						AGACATACTGGAGAGAAATCA	0.323000													3	3					0	0	0.004672	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	G	G	rs121913483		TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562000		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				10	16					0	0	0.004990	0	0
FGFR3	2261	broad.mit.edu	37	4	1803584	1803584	+	Silent	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:1803584C>A	uc003gdr.3	+	7	1018	c.762C>A	c.(760-762)ATC>ATA	p.I254I	FGFR3_uc003gdu.2_Silent_p.I254I|FGFR3_uc003gds.3_Silent_p.I254I|FGFR3_uc003gdq.3_Silent_p.I254I|FGFR3_uc010icb.1_Silent_p.I96I|FGFR3_uc003gdt.1_Silent_p.I96I	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	254	Ig-like C2-type 3.|Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACCGGCCCATCCTGCAGGCGG	0.557000		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				10	14					4.72057e-08	5.41869e-08	0.021523	1	0
FGFR3	2261	broad.mit.edu	37	4	1803749	1803749	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:1803749C>T	uc003gdr.3	+	7	1183	c.927C>T	c.(925-927)CTC>CTT	p.L309L	FGFR3_uc003gdu.2_Silent_p.L309L|FGFR3_uc003gds.3_Silent_p.L309L|FGFR3_uc003gdq.3_Silent_p.L309L|FGFR3_uc010icb.1_Intron|FGFR3_uc003gdt.1_Intron	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	309	Ig-like C2-type 3.|Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	TTACCGTGCTCAAGGTGGGCC	0.662000		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				11	10					0	0	0.016723	0	0
UNC5C	8633	broad.mit.edu	37	4	96127913	96127913	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:96127913G>T	uc003htp.1	-	11	1922	c.1768C>A	c.(1768-1770)CCT>ACT	p.P590T	UNC5C_uc010ilc.1_Missense_Mutation_p.P609T	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	590	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CTCACCACAGGGGTCAAAAGT	0.537000													20	96					4.35082e-09	5.06559e-09	0.010504	1	0
EXOSC9	5393	broad.mit.edu	37	4	122722582	122722582	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:122722582G>A	uc003iea.2	+	1	111	c.3G>A	c.(1-3)ATG>ATA	p.M1I	EXOSC9_uc003idz.2_Missense_Mutation_p.M1I|EXOSC9_uc003ieb.2_5'Flank	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	1	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						CCAACACCATGAAGGAAACGC	0.607000													74	94					0	0	0.014410	0	0
TRIML1	339976	broad.mit.edu	37	4	189068521	189068521	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:189068521G>A	uc003izm.1	+	6	1517	c.1402G>A	c.(1402-1404)GTC>ATC	p.V468I	TRIML1_uc003izn.1_Missense_Mutation_p.V192I	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	468	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GAACAGCCACGTCTGAGGGGC	0.542000													23	37					0	0	0.014410	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725009	140725009	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:140725009C>T	uc003ljm.1	+	1	1409	c.1409C>T	c.(1408-1410)TCC>TTC	p.S470F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.S230F|PCDHGA3_uc011dap.1_Missense_Mutation_p.S470F	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	470	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGAGCCTCCATCTTCTCA	0.547000													150	126					0	0	0.014410	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811015	140811015	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:140811015T>C	uc003lkt.1	+	1	858	c.689T>C	c.(688-690)GTG>GCG	p.V230A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.V230A	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	230	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCATCCGCGTGATGGTTCTG	0.657000													57	78					0	0	0.014410	0	0
CLINT1	9685	broad.mit.edu	37	5	157240138	157240138	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:157240138C>G	uc003lxj.1	-	5	640	c.450G>C	c.(448-450)AAG>AAC	p.K150N	CLINT1_uc003lxi.1_Missense_Mutation_p.K132N|CLINT1_uc011ddv.1_Missense_Mutation_p.K150N	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	150					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTTTGCTTTCTTTCGCTCTT	0.423000													54	54					0	0	0.014410	0	0
NSD1	64324	broad.mit.edu	37	5	176710832	176710832	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:176710832C>G	uc003mfr.3	+	20	6192	c.6054C>G	c.(6052-6054)TTC>TTG	p.F2018L	NSD1_uc003mft.3_Missense_Mutation_p.F1749L|NSD1_uc011dfx.1_Missense_Mutation_p.F1666L	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2018	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ATGCTCGGTTCATGAATCATT	0.453000			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			3	148					0	0	0.004672	0	0
DBN1	1627	broad.mit.edu	37	5	176895847	176895847	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:176895847C>G	uc003mgy.2	-	2	312	c.140G>C	c.(139-141)GGA>GCA	p.G47A	DBN1_uc003mgx.2_Missense_Mutation_p.G49A|DBN1_uc010jkn.1_5'UTR|DBN1_uc003mgz.1_5'UTR	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	47	ADF-H.				actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATTCCTACCTCCTGATGCTGC	0.612000													5	158					0	0	0.003080	0	0
FLT4	2324	broad.mit.edu	37	5	180048230	180048230	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:180048230C>T	uc003mma.3	-	14	2122	c.2043G>A	c.(2041-2043)ACG>ACA	p.T681T	FLT4_uc003mlz.3_Silent_p.T681T|FLT4_uc003mmb.1_Silent_p.T214T|FLT4_uc011dgy.1_Silent_p.T681T	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	681	Ig-like C2-type 7.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCAAGTTCTGCGTGAGCCGAG	0.637000									Congenital_Hereditary_Lymphedema				53	45					0	0	0.014410	0	0
OR14J1	442191	broad.mit.edu	37	6	29274483	29274483	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:29274483C>T	uc011dln.1	+	1	17	c.17C>T	c.(16-18)TCA>TTA	p.S6L		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AATTTGACTTCAATGAGTGGA	0.403000													41	41					0	0	0.009718	0	0
BRD2	6046	broad.mit.edu	37	6	32945959	32945959	+	Silent	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:32945959C>G	uc003ocn.3	+	10	3336	c.1635C>G	c.(1633-1635)CCC>CCG	p.P545P	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.P545P|BRD2_uc003ocp.3_Silent_p.P425P|BRD2_uc010juh.2_Silent_p.P545P	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	545	Arg/Lys-rich (highly basic).				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TATCCAAGCCCAAGAGGAAAA	0.463000													52	61					0	0	0.014410	0	0
BRD2	6046	broad.mit.edu	37	6	32947799	32947799	+	Nonsense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:32947799C>G	uc003ocn.3	+	11	3737	c.2036C>G	c.(2035-2037)TCA>TGA	p.S679*	BRD2_uc003ocq.3_Nonsense_Mutation_p.S679*|BRD2_uc003ocp.3_Nonsense_Mutation_p.S559*|BRD2_uc010juh.2_Nonsense_Mutation_p.S714*	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	679	ET.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TTACGTGATTCAAACCCAGAA	0.498000													46	68					0	0	0.011902	0	0
EYS	346007	broad.mit.edu	37	6	66204905	66204905	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:66204905C>T	uc011dxu.1	-	4	937	c.399G>A	c.(397-399)ATG>ATA	p.M133I	EYS_uc003peq.2_Missense_Mutation_p.M133I|EYS_uc003per.1_Missense_Mutation_p.M133I|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	133					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TAACAGTGTGCATTCCTTTTA	0.393000													4	115					0	0	0.021553	0	0
SLC22A2	6582	broad.mit.edu	37	6	160679695	160679695	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:160679695G>T	uc003qtf.2	-	1	265	c.95C>A	c.(94-96)ACC>AAC	p.T32N	SLC22A2_uc003qte.1_Missense_Mutation_p.T32N|SLC22A2_uc003qth.1_Missense_Mutation_p.T32N	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	32	Helical; (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GGGCGCGAAGGTAGCCGAGAG	0.612000													6	94					4.68919e-08	5.41869e-08	0.008291	1	0
HECW1	23072	broad.mit.edu	37	7	43519234	43519234	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:43519234G>C	uc003tid.1	+	17	3730	c.3125G>C	c.(3124-3126)CGA>CCA	p.R1042P	HECW1_uc011kbi.1_Missense_Mutation_p.R1008P	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1042	WW 2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CACAACAGTCGAGCTACCACT	0.493000													4	302					0	0	0.014758	0	0
RELN	5649	broad.mit.edu	37	7	103138606	103138606	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:103138606G>C	uc003vca.2	-	54	8921	c.8761C>G	c.(8761-8763)CTT>GTT	p.L2921V	RELN_uc010liz.2_Missense_Mutation_p.L2921V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2921					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCTCGGCAAGAATTCCACAC	0.433000													3	185					0	0	0.004672	0	0
FAM71F1	84691	broad.mit.edu	37	7	128363345	128363345	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:128363345C>T	uc003vno.1	+	4	835	c.782C>T	c.(781-783)GCC>GTC	p.A261V	FAM71F1_uc010llo.1_Missense_Mutation_p.A162V|FAM71F1_uc011koq.1_Missense_Mutation_p.A153V|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.A162V|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.A261V	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	261										skin(1)	1						CAGATTTTTGCCGACTTACAC	0.502000													5	233					0	0	0.021553	0	0
CHRM2	1129	broad.mit.edu	37	7	136700056	136700056	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:136700056G>T	uc003vtf.1	+	4	1067	c.444G>T	c.(442-444)TGG>TGT	p.W148C	CHRM2_uc003vtg.1_Missense_Mutation_p.W148C|CHRM2_uc003vtj.1_Missense_Mutation_p.W148C|CHRM2_uc003vtk.1_Missense_Mutation_p.W148C|CHRM2_uc003vtl.1_Missense_Mutation_p.W148C|CHRM2_uc003vtm.1_Missense_Mutation_p.W148C|CHRM2_uc003vti.1_Missense_Mutation_p.W148C|CHRM2_uc003vto.1_Missense_Mutation_p.W148C|CHRM2_uc003vtn.1_Missense_Mutation_p.W148C|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	148	Helical; Name=4; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CAGCTGCCTGGGTCCTCTCTT	0.488000													8	65					7.48243e-07	8.46969e-07	0.006214	1	0
PRKAG2	51422	broad.mit.edu	37	7	151372582	151372582	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:151372582C>G	uc003wkk.2	-	4	1219	c.608G>C	c.(607-609)AGG>ACG	p.R203T	PRKAG2_uc011kvl.1_Missense_Mutation_p.R79T|PRKAG2_uc003wkj.2_Missense_Mutation_p.R159T|PRKAG2_uc010lqe.1_RNA|PRKAG2_uc003wkm.1_Missense_Mutation_p.R203T	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	203					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CGGGCAGAACCTCTGCCCTGT	0.587000													50	59					0	0	0.014410	0	0
MLL3	58508	broad.mit.edu	37	7	151879016	151879016	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:151879016G>A	uc003wla.2	-	36	6148	c.5929C>T	c.(5929-5931)CAA>TAA	p.Q1977*	MLL3_uc003wkz.2_Nonsense_Mutation_p.Q1038*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1977	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTGGGAAATTGATCTGTCATC	0.458000			N		medulloblastoma								87	563					0	0	0.014410	0	0
ERLIN2	11160	broad.mit.edu	37	8	37597912	37597912	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr8:37597912G>A	uc003xke.3	+	3	252	c.137G>A	c.(136-138)GGC>GAC	p.G46D	uc003xkb.1_5'Flank|ERLIN2_uc003xkc.3_Missense_Mutation_p.G46D|ERLIN2_uc003xkd.2_Missense_Mutation_p.G46D|ERLIN2_uc003xkf.3_Missense_Mutation_p.G46D|ERLIN2_uc003xkg.2_Missense_Mutation_p.G46D	NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	46	Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TCGACCAGCGGCCCTGGTTTC	0.537000													16	494					0	0	0.028581	0	0
ST18	9705	broad.mit.edu	37	8	53028901	53028901	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr8:53028901C>T	uc003xqz.2	-	20	3093	c.2937G>A	c.(2935-2937)CTG>CTA	p.L979L	ST18_uc011ldq.1_Silent_p.L626L|ST18_uc011ldr.1_Silent_p.L944L|ST18_uc011lds.1_Silent_p.L884L|ST18_uc003xra.2_Silent_p.L979L	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	979	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCAGCTCTTTCAGCAGACTTT	0.433000													70	60					0	0	0.014410	0	0
ST18	9705	broad.mit.edu	37	8	53028912	53028912	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr8:53028912C>T	uc003xqz.2	-	20	3082	c.2926G>A	c.(2926-2928)GAA>AAA	p.E976K	ST18_uc011ldq.1_Missense_Mutation_p.E623K|ST18_uc011ldr.1_Missense_Mutation_p.E941K|ST18_uc011lds.1_Missense_Mutation_p.E881K|ST18_uc003xra.2_Missense_Mutation_p.E976K	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	976	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AGCAGACTTTCATTGTTCTGT	0.438000													61	62					0	0	0.014410	0	0
GRHL2	79977	broad.mit.edu	37	8	102631907	102631907	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr8:102631907C>G	uc010mbu.2	+	9	1569	c.1239C>G	c.(1237-1239)ATC>ATG	p.I413M		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	413						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ATTGCCAGATCAAGGTCTTCT	0.338000													5	187					0	0	0.021553	0	0
VLDLR	7436	broad.mit.edu	37	9	2651933	2651933	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr9:2651933G>A	uc003zhk.1	+	17	2792	c.2395G>A	c.(2395-2397)GCA>ACA	p.A799T	VLDLR_uc003zhl.1_Missense_Mutation_p.A771T|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Missense_Mutation_p.A730T	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	799	Helical; (Potential).				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity	p.A799T(1)		ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		GACTTCTGCCGCATGGGCCAT	0.433000													32	73					0	0	0.015359	0	0
TYRP1	7306	broad.mit.edu	37	9	12704628	12704628	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr9:12704628C>A	uc003zkv.3	+	6	1362	c.1184C>A	c.(1183-1185)CCA>CAA	p.P395Q		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	395	Lumenal, melanosome (Potential).			PN -> SQ (in Ref. 7; CAA35820).	melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		CATTTGTCTCCAAATGATCCT	0.443000									Oculocutaneous_Albinism				34	74					3.90053e-15	4.6749e-15	0.012213	1	0
C9orf24	84688	broad.mit.edu	37	9	34397497	34397497	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr9:34397497C>T	uc003zuh.1	-	1	353	c.135G>A	c.(133-135)CCG>CCA	p.P45P		NM_032596	NP_115985	Q8NCR6	CI024_HUMAN	testes development-related NYD-SP22 isoform 1	45										ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.123)		TCCCACTTACCGGAGTCAGAA	0.522000													90	208					0	0	0.014410	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396007	38396007	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr9:38396007C>T	uc004aay.2	+	2	374	c.262C>T	c.(262-264)CGC>TGC	p.R88C		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	88					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GGAAGCCTTCCGCCTGGGGTC	0.677000													21	257					0	0	0.010504	0	0
Unknown	0	broad.mit.edu	37	MT	3413	3413	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chrM:3413G>A	uc004cos.3	+	2		c.1706G>A			uc011mfh.1_5'Flank					Homo sapiens mRNA expressed only in placental villi, clone SMAP47.																		ACTACGCAAAGGCCCCAACGT	0.488000													11	7					0	0	0.016723	0	0
Unknown	0	broad.mit.edu	37	MT	12957	12957	+	RNA	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chrM:12957T>C	uc004cox.3	+	1		c.621T>C			uc004coy.2_5'Flank					Homo sapiens NADH dehydrogenase subunit 5 (MTND5) mRNA, RNA 5, complete cds; mitochondrial gene for mitochondrial product.																		CTAAACGCTAATCCAAGCCTC	0.522000													17	9					0	0	0.012319	0	0
ZMYM3	9203	broad.mit.edu	37	X	70472882	70472882	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chrX:70472882C>G	uc004dzh.1	-	2	311	c.224G>C	c.(223-225)GGA>GCA	p.G75A	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.G75A|ZMYM3_uc004dzj.1_Missense_Mutation_p.G75A|ZMYM3_uc011mpu.1_5'Flank|ZMYM3_uc004dzk.3_Missense_Mutation_p.G75A|ZMYM3_uc004dzl.3_Missense_Mutation_p.G75A|ZMYM3_uc004dzm.3_Missense_Mutation_p.G75A	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	75					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CTCAGTGGCTCCATCCAGGAC	0.652000													3	35					0	0	0.009096	0	0
STAG2	10735	broad.mit.edu	37	X	123176469	123176469	+	Nonsense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chrX:123176469C>T	uc004etz.3	+	6	775	c.436C>T	c.(436-438)CGA>TGA	p.R146*	STAG2_uc004eua.2_Nonsense_Mutation_p.R146*|STAG2_uc004eub.2_Nonsense_Mutation_p.R146*|STAG2_uc004euc.2_Nonsense_Mutation_p.R146*|STAG2_uc004eud.2_Nonsense_Mutation_p.R146*|STAG2_uc004eue.2_Nonsense_Mutation_p.R146*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	146					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGAGATAATTCGAAAAATGAC	0.284000													71	4					0	0	0.014410	0	0
IL9R	3581	broad.mit.edu	37	X	155232601	155232601	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chrX:155232601G>A	uc004fnv.1	+	2	238	c.59G>A	c.(58-60)CGA>CAA	p.R20Q	IL9R_uc010nvn.2_5'UTR|IL9R_uc004fnu.1_Missense_Mutation_p.R67Q	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	20					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCCCTGAGGCGAGACATGGGC	0.612000													131	136					0	0	0.014410	0	0
CCNL2	81669	broad.mit.edu	37	1	1334456	1334456	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:1334456G>A	uc001afi.2	-	1	263	c.231C>T	c.(229-231)CTC>CTT	p.L77L	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Silent_p.L77L|CCNL2_uc001afj.2_Silent_p.L77L|CCNL2_uc001afk.2_Silent_p.L77L|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	77					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CCACCACGCGGAGGTCGGTCT	0.692000													11	18					0	0	0.002450	0	0
CCNL2	81669	broad.mit.edu	37	1	1334592	1334592	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:1334592G>A	uc001afi.2	-	1	127	c.95C>T	c.(94-96)TCG>TTG	p.S32L	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Missense_Mutation_p.S32L|CCNL2_uc001afj.2_Missense_Mutation_p.S32L|CCNL2_uc001afk.2_Missense_Mutation_p.S32L|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	32					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CACCCCCTGCGACCCTGAGGG	0.607000													21	21					0	0	0.010504	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6528353	6528353	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:6528353C>T	uc001ano.1	-	21	2812	c.2711G>A	c.(2710-2712)CGA>CAA	p.R904Q	PLEKHG5_uc001ann.1_Missense_Mutation_p.R885Q|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Missense_Mutation_p.R925Q|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Missense_Mutation_p.R409Q|PLEKHG5_uc009vma.1_Missense_Mutation_p.R688Q|PLEKHG5_uc010nzr.1_Missense_Mutation_p.R917Q|PLEKHG5_uc001ank.1_Missense_Mutation_p.R848Q|PLEKHG5_uc009vmb.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anl.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anm.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anr.1_Missense_Mutation_p.R111Q	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	904					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GGAAGGAACTCGTGGGGACTC	0.662000													7	7					0	0	0.001984	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854436	12854436	+	Silent	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:12854436G>C	uc001auj.1	+	3	763	c.660G>C	c.(658-660)CTG>CTC	p.L220L		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	220											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCACGTCTGATAAGAAAGC	0.393000													333	356					0	0	0.014410	0	0
CROCCL1	84809	broad.mit.edu	37	1	16946407	16946407	+	RNA	SNP	T	G	G	rs10796418	by1000genomes	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:16946407T>G	uc010ocf.1	-	3		c.491A>C			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						AGCAATCTCCTCACTCAGCTG	0.672000													6	28					0	0	0.001984	0	0
THRAP3	9967	broad.mit.edu	37	1	36748232	36748232	+	Missense_Mutation	SNP	G	A	A	rs148045717		TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:36748232G>A	uc001cae.3	+	3	292	c.68G>A	c.(67-69)CGT>CAT	p.R23H	THRAP3_uc001caf.3_Missense_Mutation_p.R23H|THRAP3_uc001cag.1_Missense_Mutation_p.R23H	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	23	Arg-rich.|Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCAAGATCTCGTTCTCGTTCA	0.453000			T	USP6	aneurysmal bone cysts								75	96					0	0	0.014410	0	0
MACF1	23499	broad.mit.edu	37	1	39910503	39910503	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:39910503G>C	uc010oiu.1	+	45	15061	c.14930G>C	c.(14929-14931)AGA>ACA	p.R4977T	MACF1_uc010ois.1_Missense_Mutation_p.R4475T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6542	Spectrin 14.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATGGAAGAAAGAAAGGTACAG	0.418000													44	54					0	0	0.009718	0	0
MACF1	23499	broad.mit.edu	37	1	39926417	39926417	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:39926417G>C	uc010oiu.1	+	57	16934	c.16803G>C	c.(16801-16803)CAG>CAC	p.Q5601H	MACF1_uc010ois.1_Missense_Mutation_p.Q5099H|MACF1_uc001cde.1_5'Flank|MACF1_uc001cdf.1_5'Flank	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7057	1 (Potential).|EF-hand 1.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATAAGGACCAGGATGGGAAGA	0.438000													5	267					0	0	0.001168	0	0
ST7L	54879	broad.mit.edu	37	1	113126670	113126670	+	Silent	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:113126670T>C	uc001ecd.2	-	7	1085	c.780A>G	c.(778-780)GCA>GCG	p.A260A	ST7L_uc009wgh.2_Intron|ST7L_uc001ecc.2_Silent_p.A77A|ST7L_uc010owg.1_Silent_p.A195A|ST7L_uc010owh.1_Intron|ST7L_uc001ece.2_Silent_p.A260A|ST7L_uc001ecf.2_Silent_p.A243A|ST7L_uc001ecg.2_RNA|ST7L_uc010owi.1_Silent_p.A195A|ST7L_uc001ech.2_Silent_p.A243A|ST7L_uc001eci.2_Silent_p.A260A|ST7L_uc009wgi.1_RNA|ST7L_uc010owj.1_Silent_p.A243A	NM_017744	NP_060214	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7-like isoform 1	260					negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGCCTTGAGTGCCTGTTTAA	0.433000													86	97					0	0	0.014410	0	0
ATP1A1	476	broad.mit.edu	37	1	116931284	116931284	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:116931284G>A	uc001ege.2	+	6	865	c.526G>A	c.(526-528)GAG>AAG	p.E176K	ATP1A1_uc010owv.1_Missense_Mutation_p.E145K|ATP1A1_uc010oww.1_Missense_Mutation_p.E176K|ATP1A1_uc010owx.1_Missense_Mutation_p.E145K	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	176	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TCGAAATGGTGAGAAAATGAG	0.398000													84	133					0	0	0.014410	0	0
LOC200030	200030	broad.mit.edu	37	1	148025829	148025829	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:148025829C>T	uc001eqf.2	-	7	1058	c.1023G>A	c.(1021-1023)ATG>ATA	p.M341I	LOC200030_uc001eqe.2_5'UTR|LOC200030_uc001eqg.2_5'UTR|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Missense_Mutation_p.M1I|NBPF14_uc001eqs.1_5'Flank	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	341	Potential.					cytoplasm					0						CATTCCTCAGCATAGATTTTA	0.532000													116	384					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	1	148882025	148882025	+	RNA	SNP	C	T	T	rs150449871	by1000genomes	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:148882025C>T	uc009wkv.1	+	3		c.246C>T								Homo sapiens cDNA, FLJ17483.																		TGTTTTCTAGCAGTGACAAAT	0.343000													7	133					0	0	0.001984	0	0
TDRD10	126668	broad.mit.edu	37	1	154493835	154493835	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:154493835G>A	uc009wow.2	+	6	1087	c.249G>A	c.(247-249)GTG>GTA	p.V83V	TDRD10_uc001ffd.2_Silent_p.V83V|TDRD10_uc001ffe.2_Silent_p.V4V	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	83	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGCAGAAAGTGACACTTGCAA	0.502000													30	304					0	0	0.010818	0	0
F5	2153	broad.mit.edu	37	1	169525999	169525999	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:169525999G>C	uc001ggg.1	-	6	982	c.837C>G	c.(835-837)AAC>AAG	p.N279K	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	279	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCTTATGATGGTTCTGCTCCA	0.517000													4	111					0	0	0.009096	0	0
XPR1	9213	broad.mit.edu	37	1	180849312	180849312	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:180849312G>C	uc001goi.2	+	14	2101	c.1909G>C	c.(1909-1911)GAT>CAT	p.D637H	XPR1_uc009wxn.2_Missense_Mutation_p.D572H	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	637	EXS.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						CCTGAACGCAGATGATCAGAC	0.517000													83	83					0	0	0.014410	0	0
LRRN2	10446	broad.mit.edu	37	1	204587907	204587907	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:204587907C>T	uc001hbe.1	-	3	1602	c.1214G>A	c.(1213-1215)CGC>CAC	p.R405H	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.R405H|LRRN2_uc009xbf.1_Missense_Mutation_p.R405H|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	405	Extracellular (Potential).|LRRCT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GACCGGGAGGCGCTGGAGGTC	0.662000													4	69					0	0	0.003080	0	0
SLC26A9	115019	broad.mit.edu	37	1	205888030	205888030	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:205888030C>T	uc001hdq.2	-	19	2308	c.2194G>A	c.(2194-2196)GAC>AAC	p.D732N	SLC26A9_uc001hdm.2_5'Flank|SLC26A9_uc001hdn.2_5'Flank|SLC26A9_uc001hdo.2_Missense_Mutation_p.D400N|SLC26A9_uc001hdp.2_Missense_Mutation_p.D732N	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	732	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGGACTGCGTCATGTATGCTG	0.517000											OREG0014164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	261	295					0	0	0.014410	0	0
NEBL	10529	broad.mit.edu	37	10	21309109	21309109	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr10:21309109G>A	uc001iqk.2	-	3	540	c.186C>T	c.(184-186)TTC>TTT	p.F62F		NM_213569	NP_998734	O76041	NEBL_HUMAN	nebulette non-muscle isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CCACCGTGGTGAAGGACTGCT	0.413000													8	144					0	0	0.006214	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49667829	49667829	+	Missense_Mutation	SNP	C	T	T	rs75710233	byFrequency	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr10:49667829C>T	uc001jgt.2	-	5	854	c.557G>A	c.(556-558)CGC>CAC	p.R186H	ARHGAP22_uc001jgs.2_Missense_Mutation_p.R96H|ARHGAP22_uc001jgu.2_Missense_Mutation_p.R202H|ARHGAP22_uc010qgl.1_Missense_Mutation_p.R143H|ARHGAP22_uc010qgm.1_Missense_Mutation_p.R192H|ARHGAP22_uc001jgv.2_5'UTR	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	186	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						AGTGAGCCCGCGCTCCCGGAT	0.642000													48	124					0	0	0.014410	0	0
SGMS1	259230	broad.mit.edu	37	10	52071078	52071078	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr10:52071078T>C	uc001jje.2	-	9	1793	c.839A>G	c.(838-840)TAT>TGT	p.Y280C	SGMS1_uc010qhk.1_Missense_Mutation_p.Y111C|SGMS1_uc009xot.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	286	Helical; (Potential).				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						GCTGTACAGATAGTCCCCACA	0.453000													51	58					0	0	0.014410	0	0
IDE	3416	broad.mit.edu	37	10	94297234	94297234	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr10:94297234G>C	uc001kia.2	-	2	248	c.172C>G	c.(172-174)CCT>GCT	p.P58A		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	58					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTCTTCAGGAGACTTGGTA	0.388000													79	110					0	0	0.014410	0	0
WDR11	55717	broad.mit.edu	37	10	122618295	122618295	+	Silent	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr10:122618295C>A	uc010qtf.1	+	3	577	c.339C>A	c.(337-339)GCC>GCA	p.A113A	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	113	WD 2.					integral to membrane					0						AAGAGCATGCCAAGCCTATCC	0.468000													5	56					2.61681e-11	2.97195e-11	0.002450	1	0
RIC8A	60626	broad.mit.edu	37	11	209483	209483	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:209483T>A	uc001log.2	+	3	534	c.209T>A	c.(208-210)GTC>GAC	p.V70D	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Missense_Mutation_p.V70D|RIC8A_uc001loh.2_Missense_Mutation_p.V63D	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	70						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTGCAGAGTGTCCGAATCCTG	0.642000													21	66					0	0	0.008871	0	0
OR4S2	219431	broad.mit.edu	37	11	55418712	55418712	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:55418712C>T	uc001nhs.1	+	1	333	c.333C>T	c.(331-333)TTC>TTT	p.F111F		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				CTGAGATCTTCATCCTTACTG	0.403000													17	542					0	0	0.007413	0	0
APLNR	187	broad.mit.edu	37	11	57004337	57004337	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:57004337G>C	uc001njo.2	-	1	591	c.142C>G	c.(142-144)CTG>GTG	p.L48V	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	48	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						CAGAGCACCAGACCGTTGCCC	0.592000													62	72					0	0	0.014410	0	0
MS4A15	219995	broad.mit.edu	37	11	60540926	60540926	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:60540926T>A	uc009ynf.1	+	5	687	c.467T>A	c.(466-468)ATT>AAT	p.I156N	MS4A15_uc001npx.2_Missense_Mutation_p.I63N|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Missense_Mutation_p.I115N	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	156	Helical; (Potential).					integral to membrane	receptor activity			lung(1)	1						GGGACAGCCATTCTGCTCATG	0.572000													30	25					0	0	0.003755	0	0
VWCE	220001	broad.mit.edu	37	11	61026184	61026184	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:61026184G>A	uc001nra.2	-	20	3110	c.2831C>T	c.(2830-2832)CCA>CTA	p.P944L	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	944						extracellular region	calcium ion binding			ovary(1)	1						AGCCCCCACTGGGGGCTGCTG	0.662000													33	89					0	0	0.014410	0	0
STARD10	10809	broad.mit.edu	37	11	72470333	72470333	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:72470333C>G	uc001osy.2	-	3	592	c.301G>C	c.(301-303)GAG>CAG	p.E101Q	ARAP1_uc001osv.2_Intron|STARD10_uc001osz.3_Missense_Mutation_p.E101Q|STARD10_uc001ota.2_Missense_Mutation_p.E55Q|STARD10_uc001otb.2_Missense_Mutation_p.E101Q	NM_006645	NP_006636	Q9Y365	PCTL_HUMAN	START domain containing 10	101	START.										0			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			TCAAAAGTCTCAATGACGTTG	0.562000													58	58					0	0	0.014410	0	0
ARRB1	408	broad.mit.edu	37	11	74985127	74985127	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:74985127G>C	uc001owe.1	-	11	1127	c.905C>G	c.(904-906)TCT>TGT	p.S302C	ARRB1_uc001owf.1_Missense_Mutation_p.S302C	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	302					G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						CAGGGTGCTAGAGGCCAAGTT	0.602000													139	167					0	0	0.014410	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48142257	48142257	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr12:48142257G>A	uc009zkp.2	-	11	1537	c.1097C>T	c.(1096-1098)TCC>TTC	p.S366F	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Missense_Mutation_p.S366F|RAPGEF3_uc001rpz.3_Missense_Mutation_p.S408F|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Missense_Mutation_p.S420F	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	366					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		ATGAGCACTGGAATCTGGTCC	0.478000													24	43					0	0	0.005443	0	0
MLL2	8085	broad.mit.edu	37	12	49425839	49425839	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr12:49425839G>A	uc001rta.3	-	39	12649	c.12649C>T	c.(12649-12651)CAG>TAG	p.Q4217*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4217	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGCTGCTGCTGAGGACTTAAG	0.622000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			21	33					0	0	0.008361	0	0
MLL2	8085	broad.mit.edu	37	12	49426526	49426526	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr12:49426526G>A	uc001rta.3	-	39	11962	c.11962C>T	c.(11962-11964)CAG>TAG	p.Q3988*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3988	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGTTGTTGCTGAGGAGACAGT	0.378000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			13	14					0	0	0.013537	0	0
HSP90B1	7184	broad.mit.edu	37	12	104327895	104327895	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr12:104327895G>C	uc001tkb.1	+	5	678	c.573G>C	c.(571-573)TTG>TTC	p.L191F	HSP90B1_uc010swg.1_Intron|HSP90B1_uc009zui.1_Missense_Mutation_p.L191F	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	191					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CTTCTGAATTGATTGGCCAGT	0.428000													4	215					0	0	0.001168	0	0
INSM2	84684	broad.mit.edu	37	14	36005048	36005048	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:36005048C>T	uc001wth.1	+	1	1801	c.1590C>T	c.(1588-1590)TGC>TGT	p.C530C		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	530	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		GCAAGCACTGCCCGTCCACTT	0.627000													23	82					0	0	0.012319	0	0
FKBP3	2287	broad.mit.edu	37	14	45603575	45603575	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:45603575G>A	uc010tqf.1	-	1	158	c.85C>T	c.(85-87)CTG>TTG	p.L29L	FANCM_uc001wwc.2_5'Flank|FANCM_uc001wwd.3_5'Flank|FANCM_uc010anf.2_5'Flank	NM_002013	NP_002004	Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	29					protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity				0						TGTTCCTGCAGAAACTTGATA	0.652000													41	83					0	0	0.010771	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256349	69256349	+	Silent	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:69256349C>G	uc001xkh.1	-	2	1048	c.918G>C	c.(916-918)CTG>CTC	p.L306L	ZFP36L1_uc001xki.1_Silent_p.L306L	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	306					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TGGAGCTGCTCAGGTAGCCCT	0.597000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	92					0	0	0.014410	0	0
MLH3	27030	broad.mit.edu	37	14	75514890	75514890	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:75514890G>C	uc001xrd.1	-	2	1685	c.1469C>G	c.(1468-1470)TCT>TGT	p.S490C	MLH3_uc001xre.1_Missense_Mutation_p.S490C|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	490					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TTCCAGGAAAGATTTTTTATG	0.378000								MMR					118	190					0	0	0.014410	0	0
PPP2R5C	5527	broad.mit.edu	37	14	102391505	102391505	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr14:102391505C>G	uc001yko.2	+	14	1611	c.1471C>G	c.(1471-1473)CCT>GCT	p.P491A	PPP2R5C_uc010txr.1_Missense_Mutation_p.P522A|PPP2R5C_uc001ykk.2_Missense_Mutation_p.P507A|PPP2R5C_uc001ykp.2_Missense_Mutation_p.P452A	NM_002719	NP_002710	Q13362	2A5G_HUMAN	gamma isoform of regulatory subunit B56, protein	491					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity			ovary(1)|breast(1)	2						GAAGGACCGTCCTCTTGCACG	0.552000													6	374					0	0	0.001984	0	0
SNORD116-1	100033413	broad.mit.edu	37	15	25296712	25296712	+	RNA	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:25296712G>C	uc001yxg.2	+	1		c.90G>C				NR_003316				Homo sapiens small nucleolar RNA, C/D box 116-1 (SNORD116-1), non-coding RNA.												0						CATCGGAACTGAGGTCCAGCA	0.473000													81	91					0	0	0.014410	0	0
GABRB3	2562	broad.mit.edu	37	15	26793190	26793190	+	Nonsense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:26793190G>C	uc001zaz.2	-	9	1314	c.1172C>G	c.(1171-1173)TCA>TGA	p.S391*	GABRB3_uc010uae.1_Nonsense_Mutation_p.S306*|GABRB3_uc001zba.2_Nonsense_Mutation_p.S391*|GABRB3_uc001zbb.2_Nonsense_Mutation_p.S447*	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	391	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGATATTGCTGAATTCCTGGT	0.493000													104	127					0	0	0.014410	0	0
DMXL2	23312	broad.mit.edu	37	15	51857284	51857284	+	Splice_Site	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:51857284C>A	uc002abf.2	-	4	589	c.364_splice	c.e4+1	p.D122_splice	DMXL2_uc010ufy.1_Splice_Site_p.D122_splice|DMXL2_uc010bfa.2_Splice_Site_p.D122_splice	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2							cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TTGCTAAATACCTTGAGGATC	0.289000													23	27					3.5997e-14	4.11764e-14	0.014323	1	0
MCTP2	55784	broad.mit.edu	37	15	95019963	95019963	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr15:95019963T>C	uc002btj.2	+	21	2574	c.2509T>C	c.(2509-2511)TCC>CCC	p.S837P	MCTP2_uc010boj.2_Missense_Mutation_p.S566P|MCTP2_uc010bok.2_Missense_Mutation_p.S782P|MCTP2_uc002btl.2_Missense_Mutation_p.S425P	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	837					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAATCCCTATTCCATCGACAA	0.323000													5	170					0	0	0.001168	0	0
NTN3	4917	broad.mit.edu	37	16	2522390	2522390	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:2522390G>C	uc002cqj.2	+	1	891	c.688G>C	c.(688-690)GCA>CCA	p.A230P	TBC1D24_uc002cqk.2_5'Flank|TBC1D24_uc002cql.2_5'Flank	NM_006181	NP_006172	O00634	NET3_HUMAN	netrin 3 precursor	230	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				central_nervous_system(1)	1						GCCTAGCACGGCAGGTGACCC	0.667000													3	56					0	0	0.004672	0	0
GGA2	23062	broad.mit.edu	37	16	23503028	23503028	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:23503028G>C	uc002dlq.2	-	5	521	c.445C>G	c.(445-447)CGA>GGA	p.R149G	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	149	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		TAAGCGTCTCGAATCTTGATG	0.353000													8	333					0	0	0.004482	0	0
IL4R	3566	broad.mit.edu	37	16	27356334	27356334	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:27356334C>G	uc002don.2	+	5	596	c.354C>G	c.(352-354)AGC>AGG	p.S118R	IL4R_uc002dom.2_Missense_Mutation_p.S118R|IL4R_uc002dop.3_Missense_Mutation_p.S103R|IL4R_uc010bxy.2_Missense_Mutation_p.S118R|IL4R_uc002doo.2_5'UTR	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	118	Extracellular (Potential).			S->A: No effect on IL4 binding.	immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						TCAAGCCCAGCGAGCATGGTG	0.647000													3	128					0	0	0.004672	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29884594	29884594	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:29884594A>G	uc002duq.3	-	14	2695	c.2455T>C	c.(2455-2457)TCC>CCC	p.S819P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.S749P|SEZ6L2_uc002dur.3_Missense_Mutation_p.S749P|SEZ6L2_uc002dus.3_Missense_Mutation_p.S705P|SEZ6L2_uc010vec.1_Missense_Mutation_p.S819P|SEZ6L2_uc010ved.1_Missense_Mutation_p.S775P	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	819	Sushi 5.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GTCCACTGGGAGGGGTGGCCG	0.642000													5	46					0	0	0.013537	0	0
CX3CL1	6376	broad.mit.edu	37	16	57413597	57413597	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:57413597C>T	uc002eli.2	+	2	189	c.122C>T	c.(121-123)TCA>TTA	p.S41L		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	41	Extracellular (Potential).|Chemokine.				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						AAGATGACATCAAAGATACCT	0.517000													5	90					0	0	0.014758	0	0
Unknown	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:70268158A>C	uc010cfp.1	-	3		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333000													4	19					0	0	0.009096	0	0
WDR59	79726	broad.mit.edu	37	16	74990405	74990405	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:74990405G>A	uc002fdh.1	-	3	310	c.208C>T	c.(208-210)CAT>TAT	p.H70Y	WDR59_uc002fdi.2_Missense_Mutation_p.H70Y|WDR59_uc002fdj.2_Missense_Mutation_p.H70Y	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	70	WD 1.									ovary(1)|breast(1)	2						AAGCTGTCATGAGGATTCCAC	0.468000													40	75					0	0	0.006230	0	0
ZDHHC7	55625	broad.mit.edu	37	16	85010706	85010706	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:85010706C>T	uc002fiq.2	-	7	1098	c.745G>A	c.(745-747)GAG>AAG	p.E249K	ZDHHC7_uc010voi.1_Missense_Mutation_p.E286K|ZDHHC7_uc002fir.1_RNA	NM_017740	NP_060210	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7 isoform 2	249						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(1)	1						CTTACCGTCTCGTCGTTGCAT	0.448000													105	131					0	0	0.014410	0	0
ITGAE	3682	broad.mit.edu	37	17	3659152	3659152	+	Missense_Mutation	SNP	A	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:3659152A>T	uc002fwo.3	-	11	1310	c.1211T>A	c.(1210-1212)ATT>AAT	p.I404N		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	404	FG-GAP 3.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		ACTGAAGCCAATCTGTGCCAG	0.592000													7	7					0	0	0.003080	0	0
TP53	7157	broad.mit.edu	37	17	7579415	7579415	+	Nonsense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:7579415C>T	uc002gim.2	-	4	466	c.272G>A	c.(271-273)TGG>TAG	p.W91*	TP53_uc002gig.1_Nonsense_Mutation_p.W91*|TP53_uc002gih.2_Nonsense_Mutation_p.W91*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.W91*|TP53_uc010cni.1_Nonsense_Mutation_p.W91*|TP53_uc002gij.2_Nonsense_Mutation_p.W91*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.W52*|TP53_uc010cnk.1_Nonsense_Mutation_p.W106*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	91	Interaction with WWOX.		W -> C (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W91*(11)|p.0?(7)|p.G59fs*23(3)|p.V73fs*9(1)|p.D48fs*55(1)|p.W91fs*57(1)|p.A88fs*52(1)|p.W91fs*13(1)|p.P87fs*54(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGACAGGGGCCAGGAGGGGGC	0.632000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	97					0	0	0.012319	0	0
KRT13	3860	broad.mit.edu	37	17	39659037	39659037	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:39659037T>A	uc002hwu.1	-	5	988	c.925A>T	c.(925-927)ACC>TCC	p.T309S	KRT13_uc002hwv.1_Missense_Mutation_p.T309S|KRT13_uc002hww.2_Missense_Mutation_p.T202S|KRT13_uc010wfr.1_Missense_Mutation_p.T202S|KRT13_uc010cxo.2_Missense_Mutation_p.T309S|KRT13_uc002hwx.1_Missense_Mutation_p.T297S	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	309	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GCAGTGTTGGTAGACACCTCC	0.577000													161	198					0	0	0.014410	0	0
DBF4B	80174	broad.mit.edu	37	17	42828063	42828063	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:42828063C>T	uc002ihf.2	+	14	1503	c.1290C>T	c.(1288-1290)CTC>CTT	p.L430L	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	430					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				CCACAACCCTCCTGCCGGCCT	0.617000													57	59					0	0	0.014410	0	0
EPN3	55040	broad.mit.edu	37	17	48615544	48615544	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:48615544G>A	uc002ira.3	+	3	1102	c.667G>A	c.(667-669)GAG>AAG	p.E223K	EPN3_uc010wms.1_Missense_Mutation_p.E278K|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.E223K	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	223	UIM 1.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CATGAGCCGTGAGGAGGCAGA	0.667000													21	11					0	0	0.003330	0	0
EPN3	55040	broad.mit.edu	37	17	48616322	48616322	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:48616322G>C	uc002ira.3	+	4	1194	c.759G>C	c.(757-759)GAG>GAC	p.E253D	EPN3_uc010wms.1_Intron|EPN3_uc010wmt.1_Intron|EPN3_uc010wmu.1_Intron	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	253	UIM 2.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AGGAGCACGAGAAGGTAGTGG	0.687000													7	9					0	0	0.008291	0	0
SPATA20	64847	broad.mit.edu	37	17	48628090	48628090	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:48628090G>A	uc002irf.2	+	10	1288	c.1147G>A	c.(1147-1149)GAA>AAA	p.E383K	SPATA20_uc002irc.2_Missense_Mutation_p.E50K|SPATA20_uc002ire.2_Missense_Mutation_p.E339K|SPATA20_uc002ird.2_Missense_Mutation_p.E399K|SPATA20_uc010wmv.1_3'UTR|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	383					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CTATAGCGCAGAAGATGCAGA	0.672000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	154	190					0	0	0.014410	0	0
SPATA20	64847	broad.mit.edu	37	17	48628385	48628385	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:48628385G>A	uc002irf.2	+	11	1503	c.1362G>A	c.(1360-1362)CAG>CAA	p.Q454Q	SPATA20_uc002irc.2_Silent_p.Q121Q|SPATA20_uc002ire.2_Silent_p.Q410Q|SPATA20_uc002ird.2_Silent_p.Q470Q|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	454					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			TGCAGGGCCAGAATGTGCTGA	0.637000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	62					0	0	0.014410	0	0
TEX2	55852	broad.mit.edu	37	17	62238165	62238165	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:62238165C>G	uc002jec.2	-	8	2973	c.2800G>C	c.(2800-2802)GAA>CAA	p.E934Q	TEX2_uc002jed.2_Missense_Mutation_p.E941Q|TEX2_uc002jee.2_Missense_Mutation_p.E934Q	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	934					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CCTTACCCTTCTTTGCCAATT	0.463000													610	266					0	0	0.014410	0	0
CACNG4	27092	broad.mit.edu	37	17	65026963	65026963	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:65026963T>C	uc002jft.1	+	4	842	c.827T>C	c.(826-828)ATG>ACG	p.M276T		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	276	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			GAGCTGTCCATGTACACGCTG	0.647000													26	112					0	0	0.007291	0	0
SLC38A10	124565	broad.mit.edu	37	17	79249777	79249777	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:79249777C>T	uc002jzz.1	-	8	1279	c.904G>A	c.(904-906)GAG>AAG	p.E302K	SLC38A10_uc002jzy.1_Missense_Mutation_p.E220K|SLC38A10_uc002kab.2_Missense_Mutation_p.E302K	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	302					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ACCTGCTGCTCACACAGCAGC	0.597000													60	218					0	0	0.014410	0	0
DSC2	1824	broad.mit.edu	37	18	28660162	28660162	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr18:28660162G>C	uc002kwl.3	-	10	1874	c.1420C>G	c.(1420-1422)CCA>GCA	p.P474A	DSC2_uc002kwk.3_Missense_Mutation_p.P474A	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	474	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GTCTGTATTGGAGGGTTACAC	0.443000													201	174					0	0	0.014410	0	0
C19orf21	126353	broad.mit.edu	37	19	757669	757669	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:757669C>T	uc002lpo.2	+	2	806	c.723C>T	c.(721-723)AAC>AAT	p.N241N		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	241										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTGGCCAACGGGCACGTGG	0.672000													25	24					0	0	0.005443	0	0
PIK3R2	5296	broad.mit.edu	37	19	18279617	18279617	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:18279617G>A	uc002nia.1	+	15	2402	c.1890G>A	c.(1888-1890)ACG>ACA	p.T630T	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	630	SH2 2.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						TCAACCGCACGCAGGCAGAGG	0.657000											OREG0025359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	23					0	0	0.006122	0	0
PRR12	57479	broad.mit.edu	37	19	50099849	50099849	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:50099849G>A	uc002poo.3	+	4	2257	c.2257G>A	c.(2257-2259)GCC>ACC	p.A753T		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CGGGGCAGGCGCCAAGGAGCT	0.692000													6	11					0	0	0.001168	0	0
NLRP9	338321	broad.mit.edu	37	19	56244727	56244727	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr19:56244727C>A	uc002qly.2	-	2	498	c.470G>T	c.(469-471)GGA>GTA	p.G157V		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	157	NACHT.|ATP (Potential).					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GGTTGTTTTTCCAATTCCATC	0.408000													4	136					0.00909568	0.00964142	0.009096	1	0
ADCY3	109	broad.mit.edu	37	2	25057766	25057766	+	Missense_Mutation	SNP	G	A	A	rs142082596	by1000genomes	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:25057766G>A	uc002rfs.3	-	9	1901	c.1702C>T	c.(1702-1704)CGC>TGC	p.R568C	ADCY3_uc002rfr.3_Missense_Mutation_p.R201C|ADCY3_uc010ykm.1_Missense_Mutation_p.R568C	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	568	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TCCTGCAGGCGCAGCCTCCGG	0.652000													3	40					0	0	0.004672	0	0
ETAA1	54465	broad.mit.edu	37	2	67631299	67631299	+	Silent	SNP	A	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:67631299A>G	uc002sdz.1	+	5	1624	c.1485A>G	c.(1483-1485)CAA>CAG	p.Q495Q		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	495						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						ACGAAATTCAAAATTGTATAG	0.279000													42	40					0	0	0.006999	0	0
AFF3	3899	broad.mit.edu	37	2	100623250	100623250	+	Silent	SNP	G	A	A	rs138844530	by1000genomes	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:100623250G>A	uc002tag.2	-	6	953	c.717C>T	c.(715-717)GAC>GAT	p.D239D	AFF3_uc002taf.2_Silent_p.D264D|AFF3_uc010fiq.1_Silent_p.D239D|AFF3_uc010yvr.1_Silent_p.D393D|AFF3_uc002tah.1_Silent_p.D264D|AFF3_uc010fir.1_Silent_p.D316D|AFF3_uc002tai.2_Silent_p.D161D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	239					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GATCTTGGCCGTCCATTGGCC	0.572000													37	50					0	0	0.004878	0	0
SH3RF3	344558	broad.mit.edu	37	2	110065844	110065844	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:110065844G>A	uc010ywt.1	+	8	2047	c.2047G>A	c.(2047-2049)GCA>ACA	p.A683T		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	683							zinc ion binding			ovary(1)	1						CGTCAGTGCCGCAAACCTCAA	0.622000													3	35					0	0	0.004672	0	0
NEB	4703	broad.mit.edu	37	2	152397247	152397247	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:152397247C>T	uc010fnx.2	-	109	15839	c.15648G>A	c.(15646-15648)TTG>TTA	p.L5216L	NEB_uc002txr.2_Silent_p.L1639L	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5216	Nebulin 142.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TAGCATGCTTCAAGGCTGTGG	0.433000													8	146					0	0	0.006214	0	0
CCDC108	255101	broad.mit.edu	37	2	219886640	219886640	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:219886640C>T	uc002vjl.1	-	18	3076	c.2992G>A	c.(2992-2994)GAG>AAG	p.E998K	CCDC108_uc002vjm.3_5'Flank	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	998						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGGCCAGCTCCTTTTCCTTT	0.597000													80	57					0	0	0.014410	0	0
TUBA4A	7277	broad.mit.edu	37	2	220115274	220115274	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:220115274C>T	uc002vkt.1	-	4	1205	c.1147G>A	c.(1147-1149)GCC>ACC	p.A383T	TUBA4A_uc010zkz.1_Missense_Mutation_p.A368T|TUBA4B_uc002vku.2_5'Flank|TUBA4B_uc002vkv.1_5'Flank	NM_006000	NP_005991	P68366	TBA4A_HUMAN	tubulin, alpha 4a	383					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)	3		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCGGCGATGGCGGTCGTGTTG	0.622000													4	71					0	0	0.009096	0	0
OBSL1	23363	broad.mit.edu	37	2	220420911	220420911	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr2:220420911G>A	uc010fwk.2	-	14	4497	c.4440C>T	c.(4438-4440)GCC>GCT	p.A1480A	OBSL1_uc002vmh.1_Silent_p.A379A|OBSL1_uc010zli.1_Silent_p.A287A|OBSL1_uc010fwl.1_Silent_p.A955A	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1480	Ig-like 12.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CCCAGCGCACGGCCCCCGCTG	0.657000													5	9					0	0	0.001984	0	0
CPXM1	56265	broad.mit.edu	37	20	2775058	2775058	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr20:2775058C>A	uc002wgu.2	-	14	2047	c.1983G>T	c.(1981-1983)TGG>TGT	p.W661C	CPXM1_uc010gas.2_Missense_Mutation_p.W587C	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	661					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						TCAGCAGACGCCAATAATCCC	0.597000													19	61					1.64113e-05	1.78726e-05	0.010504	1	0
CTCFL	140690	broad.mit.edu	37	20	56090811	56090811	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr20:56090811C>G	uc010gix.1	-	5	1801	c.1139G>C	c.(1138-1140)AGA>ACA	p.R380T	CTCFL_uc010giw.1_Missense_Mutation_p.R380T|CTCFL_uc002xym.2_Missense_Mutation_p.R380T|CTCFL_uc010giz.1_5'UTR|CTCFL_uc010giy.1_5'UTR|CTCFL_uc010gja.1_Missense_Mutation_p.R380T|CTCFL_uc010gjb.1_Missense_Mutation_p.R380T|CTCFL_uc010gjc.1_Missense_Mutation_p.R380T|CTCFL_uc010gjd.1_Missense_Mutation_p.R380T|CTCFL_uc010gje.2_Missense_Mutation_p.R380T|CTCFL_uc010gjf.2_Missense_Mutation_p.R175T|CTCFL_uc010gjg.2_Missense_Mutation_p.R112T|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Missense_Mutation_p.R175T|CTCFL_uc010gjj.1_Missense_Mutation_p.R380T	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	380	C2H2-type 5.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GTAGGTATCTCTGCTGGCATA	0.483000													219	278					0	0	0.014410	0	0
ZBTB46	140685	broad.mit.edu	37	20	62407208	62407208	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr20:62407208G>A	uc002ygv.1	-	3	1246	c.1045C>T	c.(1045-1047)CTG>TTG	p.L349L	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GGAGGGCCCAGATAGCTGGCT	0.662000													85	97					0	0	0.014410	0	0
C21orf99	149992	broad.mit.edu	37	21	14439254	14439254	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr21:14439254G>A	uc002yja.3	+	10		c.2772G>A				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AGGAAAAATCGAAGAGCAACA	0.303000													12	24					0	0	0.001855	0	0
SLC25A1	6576	broad.mit.edu	37	22	19164390	19164390	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:19164390G>A	uc002zoz.2	-	6	715	c.600C>T	c.(598-600)TTC>TTT	p.F200F	SLC25A1_uc002zoy.2_Silent_p.F97F|SLC25A1_uc002zpa.2_Silent_p.F148F	NM_005984	NP_005975	P53007	TXTP_HUMAN	solute carrier family 25 (mitochondrial carrier;	200	Helical; Name=4; (Potential).|Solcar 2.				gluconeogenesis|long-chain fatty-acyl-CoA biosynthetic process|mitochondrial citrate transport|triglyceride biosynthetic process	integral to membrane|mitochondrial inner membrane	citrate transmembrane transporter activity|protein binding				0	Colorectal(54;0.0993)	all_lung(157;9.94e-09)		Lung(27;0.124)		AGGTCATGACGAAGAAGCGGA	0.642000													4	125					0	0	0.001168	0	0
PICK1	9463	broad.mit.edu	37	22	38470965	38470965	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:38470965C>G	uc003auq.2	+	13	1464	c.1074C>G	c.(1072-1074)TTC>TTG	p.F358L	PICK1_uc003aur.2_Missense_Mutation_p.F358L|PICK1_uc003aus.2_Missense_Mutation_p.F358L|PICK1_uc003aut.2_Missense_Mutation_p.F358L	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	358					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					CCGACGTCTTCCCCATCGAGG	0.532000													19	37					0	0	0.007413	0	0
MKL1	57591	broad.mit.edu	37	22	40814967	40814967	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:40814967G>A	uc003ayv.1	-	9	1682	c.1475C>T	c.(1474-1476)TCG>TTG	p.S492L	MKL1_uc003ayw.1_Missense_Mutation_p.S492L|MKL1_uc010gye.1_Missense_Mutation_p.S492L|MKL1_uc010gyf.1_Missense_Mutation_p.S442L	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	492					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity	p.S492S(1)		ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTGCAGTGGCGAGGCCTGCAG	0.677000			T	RBM15	acute megakaryocytic leukemia								10	44					0	0	0.008291	0	0
PARVB	29780	broad.mit.edu	37	22	44564537	44564537	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:44564537C>T	uc003ben.2	+	13	1126	c.1074C>T	c.(1072-1074)ACC>ACT	p.T358T	PARVB_uc003bem.2_Silent_p.T391T|PARVB_uc010gzn.2_Silent_p.T283T|PARVB_uc003beo.2_Silent_p.T321T	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	358	CH 2.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				ACCTGTTCACCAAGTACAAGA	0.552000													11	86					0	0	0.010729	0	0
GTSE1	51512	broad.mit.edu	37	22	46712115	46712115	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:46712115C>T	uc011aqy.1	+	7	1450	c.1238C>T	c.(1237-1239)CCC>CTC	p.P413L	GTSE1_uc011aqz.1_Missense_Mutation_p.P260L|GTSE1_uc003bhl.1_Missense_Mutation_p.P38L|GTSE1_uc003bhm.1_Missense_Mutation_p.P38L	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	394					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CTCACGGCACCCCCCTCAGCA	0.627000													4	117					0	0	0.014758	0	0
CELSR1	9620	broad.mit.edu	37	22	46930992	46930992	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr22:46930992G>A	uc003bhw.1	-	1	2076	c.2076C>T	c.(2074-2076)TAC>TAT	p.Y692Y		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	692	Extracellular (Potential).|Cadherin 5.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GACGAAGCTCGTAGGTGGGCT	0.642000													9	28					0	0	0.013537	0	0
LHFPL4	375323	broad.mit.edu	37	3	9547649	9547649	+	Splice_Site	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:9547649G>A	uc003bry.2	-	3	929	c.643_splice	c.e3+1	p.D215_splice		NM_198560	NP_940962	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4							integral to membrane				ovary(2)|skin(1)	3	Medulloblastoma(99;0.227)					CAGCACACTCGCCTTTGTTCT	0.592000													129	140					0	0	0.014410	0	0
SLC6A11	6538	broad.mit.edu	37	3	10885923	10885923	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:10885923C>T	uc003bvz.2	+	5	682	c.648C>T	c.(646-648)GAC>GAT	p.D216D		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	216	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CCATCTCTGACGGGATCGAGC	0.587000													3	81					0	0	0.004672	0	0
EFHB	151651	broad.mit.edu	37	3	19925989	19925989	+	Silent	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:19925989G>C	uc003cbl.3	-	11	2248	c.2052C>G	c.(2050-2052)CTC>CTG	p.L684L	EFHB_uc003cbm.2_Silent_p.L554L	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	684					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						GAAGTGTCCGGAGAGTCTTTT	0.393000													78	94					0	0	0.014410	0	0
RAD54L2	23132	broad.mit.edu	37	3	51667682	51667682	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:51667682C>T	uc011bdt.1	+	7	1040	c.915C>T	c.(913-915)CAC>CAT	p.H305H	RAD54L2_uc003dbh.2_5'UTR|RAD54L2_uc011bdu.1_5'UTR|RAD54L2_uc003dbj.2_5'UTR	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	305	Helicase ATP-binding.|ATP (By similarity).					nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TTCTGGCCCACAGCATGGGTC	0.527000													6	197					0	0	0.001168	0	0
PARP3	10039	broad.mit.edu	37	3	51979556	51979556	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:51979556G>C	uc003dby.2	+	7	1278	c.907G>C	c.(907-909)GAG>CAG	p.E303Q	PARP3_uc003dbz.2_Missense_Mutation_p.E310Q	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	303					DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GGCAGTCTCTGAGCAGGAGAA	0.622000													3	99					0	0	0.004672	0	0
FLNB	2317	broad.mit.edu	37	3	58089735	58089735	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:58089735C>T	uc003djj.2	+	10	1698	c.1533C>T	c.(1531-1533)TAC>TAT	p.Y511Y	FLNB_uc010hne.2_Silent_p.Y511Y|FLNB_uc003djk.2_Silent_p.Y511Y|FLNB_uc010hnf.2_Silent_p.Y511Y|FLNB_uc003djl.2_Silent_p.Y342Y|FLNB_uc003djm.2_Silent_p.Y342Y	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	511	Filamin 3.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ATGGGGTCTACGCATTCGAGT	0.542000													4	158					0	0	0.009096	0	0
GOLGB1	2804	broad.mit.edu	37	3	121386444	121386444	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:121386444G>A	uc003eei.3	-	20	9544	c.9418C>T	c.(9418-9420)CAG>TAG	p.Q3140*	GOLGB1_uc010hrc.2_Nonsense_Mutation_p.Q3150*|GOLGB1_uc003eej.3_Nonsense_Mutation_p.Q3106*	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	3140	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AGCTGCTGCTGAGCTTCAGAA	0.423000													4	121					0	0	0.014758	0	0
COL6A6	131873	broad.mit.edu	37	3	130287049	130287049	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:130287049G>A	uc010htl.2	+	5	2033	c.2002G>A	c.(2002-2004)GAC>AAC	p.D668N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	668	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CCAGTTCAGCGACATCAATAA	0.423000													128	151					0	0	0.014410	0	0
DLG1	1739	broad.mit.edu	37	3	196771534	196771534	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:196771534G>C	uc003fxo.3	-	26	2865	c.2675C>G	c.(2674-2676)TCT>TGT	p.S892C	DLG1_uc011bub.1_Missense_Mutation_p.S788C|DLG1_uc011buc.1_Missense_Mutation_p.S776C|DLG1_uc011bud.1_Missense_Mutation_p.S575C|DLG1_uc003fxn.3_Missense_Mutation_p.S914C|DLG1_uc011bue.1_Missense_Mutation_p.S880C|DLG1_uc010ial.2_Missense_Mutation_p.S892C	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	892					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GTAAGAACCAGATTGTTCTTC	0.378000													6	210					0	0	0.001984	0	0
ZNF876P	642280	broad.mit.edu	37	4	247622	247622	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:247622G>A	uc010iba.2	+	2		c.456G>A				NR_027481				Homo sapiens cDNA clone IMAGE:4828836.												0						AGACATACTGGAGAGAAATCA	0.323000													3	14					0	0	0.004672	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	G	G	rs121913483		TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562000		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				8	9					0	0	0.010729	0	0
UNC5C	8633	broad.mit.edu	37	4	96127913	96127913	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:96127913G>T	uc003htp.1	-	11	1922	c.1768C>A	c.(1768-1770)CCT>ACT	p.P590T	UNC5C_uc010ilc.1_Missense_Mutation_p.P609T	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	590	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CTCACCACAGGGGTCAAAAGT	0.537000													16	80					3.41278e-10	3.84846e-10	0.004990	1	0
EXOSC9	5393	broad.mit.edu	37	4	122722582	122722582	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:122722582G>A	uc003iea.2	+	1	111	c.3G>A	c.(1-3)ATG>ATA	p.M1I	EXOSC9_uc003idz.2_Missense_Mutation_p.M1I|EXOSC9_uc003ieb.2_5'Flank	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	1	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						CCAACACCATGAAGGAAACGC	0.607000													58	87					0	0	0.014410	0	0
TRIML1	339976	broad.mit.edu	37	4	189068521	189068521	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr4:189068521G>A	uc003izm.1	+	6	1517	c.1402G>A	c.(1402-1404)GTC>ATC	p.V468I	TRIML1_uc003izn.1_Missense_Mutation_p.V192I	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	468	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GAACAGCCACGTCTGAGGGGC	0.542000													29	38					0	0	0.014410	0	0
WDR41	55255	broad.mit.edu	37	5	76749713	76749713	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:76749713C>A	uc003kff.1	-	6	739	c.452G>T	c.(451-453)GGT>GTT	p.G151V	WDR41_uc011csy.1_Missense_Mutation_p.G151V|WDR41_uc011csz.1_Missense_Mutation_p.G96V|WDR41_uc011cta.1_RNA|WDR41_uc011ctb.1_Intron	NM_018268	NP_060738	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	151	WD 3.										0		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		GTCATTCCCACCAGAAAGCCA	0.353000													7	146					1.06961e-07	1.18103e-07	0.003080	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140725009	140725009	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:140725009C>T	uc003ljm.1	+	1	1409	c.1409C>T	c.(1408-1410)TCC>TTC	p.S470F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.S230F|PCDHGA3_uc011dap.1_Missense_Mutation_p.S470F	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	470	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGAGCCTCCATCTTCTCA	0.547000													127	146					0	0	0.014410	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811015	140811015	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:140811015T>C	uc003lkt.1	+	1	858	c.689T>C	c.(688-690)GTG>GCG	p.V230A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.V230A	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	230	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCATCCGCGTGATGGTTCTG	0.657000													60	79					0	0	0.014410	0	0
CLINT1	9685	broad.mit.edu	37	5	157240138	157240138	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:157240138C>G	uc003lxj.1	-	5	640	c.450G>C	c.(448-450)AAG>AAC	p.K150N	CLINT1_uc003lxi.1_Missense_Mutation_p.K132N|CLINT1_uc011ddv.1_Missense_Mutation_p.K150N	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	150					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTTTGCTTTCTTTCGCTCTT	0.423000													70	73					0	0	0.014410	0	0
FLT4	2324	broad.mit.edu	37	5	180048230	180048230	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr5:180048230C>T	uc003mma.3	-	14	2122	c.2043G>A	c.(2041-2043)ACG>ACA	p.T681T	FLT4_uc003mlz.3_Silent_p.T681T|FLT4_uc003mmb.1_Silent_p.T214T|FLT4_uc011dgy.1_Silent_p.T681T	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	681	Ig-like C2-type 7.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCAAGTTCTGCGTGAGCCGAG	0.637000									Congenital_Hereditary_Lymphedema				26	27					0	0	0.006320	0	0
OR14J1	442191	broad.mit.edu	37	6	29274483	29274483	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:29274483C>T	uc011dln.1	+	1	17	c.17C>T	c.(16-18)TCA>TTA	p.S6L		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AATTTGACTTCAATGAGTGGA	0.403000													138	218					0	0	0.014410	0	0
BRD2	6046	broad.mit.edu	37	6	32945959	32945959	+	Silent	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:32945959C>G	uc003ocn.3	+	10	3336	c.1635C>G	c.(1633-1635)CCC>CCG	p.P545P	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.P545P|BRD2_uc003ocp.3_Silent_p.P425P|BRD2_uc010juh.2_Silent_p.P545P	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	545	Arg/Lys-rich (highly basic).				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TATCCAAGCCCAAGAGGAAAA	0.463000													33	48					0	0	0.012213	0	0
BRD2	6046	broad.mit.edu	37	6	32947799	32947799	+	Nonsense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:32947799C>G	uc003ocn.3	+	11	3737	c.2036C>G	c.(2035-2037)TCA>TGA	p.S679*	BRD2_uc003ocq.3_Nonsense_Mutation_p.S679*|BRD2_uc003ocp.3_Nonsense_Mutation_p.S559*|BRD2_uc010juh.2_Nonsense_Mutation_p.S714*	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	679	ET.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TTACGTGATTCAAACCCAGAA	0.498000													42	50					0	0	0.007835	0	0
RIMS1	22999	broad.mit.edu	37	6	72892038	72892038	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:72892038C>T	uc003pga.2	+	6	941	c.864C>T	c.(862-864)AGC>AGT	p.S288S	RIMS1_uc011dyb.1_5'UTR|RIMS1_uc003pgc.2_5'UTR|RIMS1_uc003pgb.3_5'UTR	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	288					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CCCTGAAGAGCGAGCGGAAAC	0.542000													3	95					0	0	0.004672	0	0
WTAP	9589	broad.mit.edu	37	6	160157288	160157288	+	Splice_Site	SNP	A	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:160157288A>T	uc003qsl.2	+	2	215	c.-7_splice	c.e2-2		WTAP_uc010kjx.2_Splice_Site|WTAP_uc003qsk.2_Splice_Site|WTAP_uc003qsm.1_Splice_Site|WTAP_uc003qsn.2_Splice_Site	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1						cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		TTTTTTTTTTAGGATTCAAGA	0.318000													5	274					0	0	0.014758	0	0
MACC1	346389	broad.mit.edu	37	7	20199090	20199090	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:20199090C>A	uc003sus.3	-	5	1203	c.894G>T	c.(892-894)AAG>AAT	p.K298N	MACC1_uc010kug.2_Missense_Mutation_p.K298N	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	298					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TGAAAGGATCCTTTCTTACTT	0.413000													21	92					2.4624e-09	2.73791e-09	0.008871	1	0
HECW1	23072	broad.mit.edu	37	7	43519234	43519234	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:43519234G>C	uc003tid.1	+	17	3730	c.3125G>C	c.(3124-3126)CGA>CCA	p.R1042P	HECW1_uc011kbi.1_Missense_Mutation_p.R1008P	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1042	WW 2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CACAACAGTCGAGCTACCACT	0.493000													7	246					0	0	0.003080	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117407188	117407188	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:117407188C>G	uc003vjf.2	-	9	2913	c.2821G>C	c.(2821-2823)GAA>CAA	p.E941Q		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	941	ANK 6.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TCTCTCCTTTCTGGCTCAAGC	0.433000													4	180					0	0	0.014758	0	0
CHRM2	1129	broad.mit.edu	37	7	136700056	136700056	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:136700056G>T	uc003vtf.1	+	4	1067	c.444G>T	c.(442-444)TGG>TGT	p.W148C	CHRM2_uc003vtg.1_Missense_Mutation_p.W148C|CHRM2_uc003vtj.1_Missense_Mutation_p.W148C|CHRM2_uc003vtk.1_Missense_Mutation_p.W148C|CHRM2_uc003vtl.1_Missense_Mutation_p.W148C|CHRM2_uc003vtm.1_Missense_Mutation_p.W148C|CHRM2_uc003vti.1_Missense_Mutation_p.W148C|CHRM2_uc003vto.1_Missense_Mutation_p.W148C|CHRM2_uc003vtn.1_Missense_Mutation_p.W148C|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	148	Helical; Name=4; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CAGCTGCCTGGGTCCTCTCTT	0.488000													21	99					2.98393e-07	3.27204e-07	0.016522	1	0
PRKAG2	51422	broad.mit.edu	37	7	151372582	151372582	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:151372582C>G	uc003wkk.2	-	4	1219	c.608G>C	c.(607-609)AGG>ACG	p.R203T	PRKAG2_uc011kvl.1_Missense_Mutation_p.R79T|PRKAG2_uc003wkj.2_Missense_Mutation_p.R159T|PRKAG2_uc010lqe.1_RNA|PRKAG2_uc003wkm.1_Missense_Mutation_p.R203T	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	203					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CGGGCAGAACCTCTGCCCTGT	0.587000													45	59					0	0	0.013114	0	0
MLL3	58508	broad.mit.edu	37	7	151879016	151879016	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr7:151879016G>A	uc003wla.2	-	36	6148	c.5929C>T	c.(5929-5931)CAA>TAA	p.Q1977*	MLL3_uc003wkz.2_Nonsense_Mutation_p.Q1038*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1977	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTGGGAAATTGATCTGTCATC	0.458000			N		medulloblastoma								93	509					0	0	0.014410	0	0
ERLIN2	11160	broad.mit.edu	37	8	37597912	37597912	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr8:37597912G>A	uc003xke.3	+	3	252	c.137G>A	c.(136-138)GGC>GAC	p.G46D	uc003xkb.1_5'Flank|ERLIN2_uc003xkc.3_Missense_Mutation_p.G46D|ERLIN2_uc003xkd.2_Missense_Mutation_p.G46D|ERLIN2_uc003xkf.3_Missense_Mutation_p.G46D|ERLIN2_uc003xkg.2_Missense_Mutation_p.G46D	NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	46	Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TCGACCAGCGGCCCTGGTTTC	0.537000													20	417					0	0	0.014323	0	0
ST18	9705	broad.mit.edu	37	8	53028901	53028901	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr8:53028901C>T	uc003xqz.2	-	20	3093	c.2937G>A	c.(2935-2937)CTG>CTA	p.L979L	ST18_uc011ldq.1_Silent_p.L626L|ST18_uc011ldr.1_Silent_p.L944L|ST18_uc011lds.1_Silent_p.L884L|ST18_uc003xra.2_Silent_p.L979L	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	979	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCAGCTCTTTCAGCAGACTTT	0.433000													64	97					0	0	0.014410	0	0
ST18	9705	broad.mit.edu	37	8	53028912	53028912	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr8:53028912C>T	uc003xqz.2	-	20	3082	c.2926G>A	c.(2926-2928)GAA>AAA	p.E976K	ST18_uc011ldq.1_Missense_Mutation_p.E623K|ST18_uc011ldr.1_Missense_Mutation_p.E941K|ST18_uc011lds.1_Missense_Mutation_p.E881K|ST18_uc003xra.2_Missense_Mutation_p.E976K	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	976	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AGCAGACTTTCATTGTTCTGT	0.438000													54	93					0	0	0.014410	0	0
GRHL2	79977	broad.mit.edu	37	8	102631907	102631907	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr8:102631907C>G	uc010mbu.2	+	9	1569	c.1239C>G	c.(1237-1239)ATC>ATG	p.I413M		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	413						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ATTGCCAGATCAAGGTCTTCT	0.338000													6	224					0	0	0.003080	0	0
VLDLR	7436	broad.mit.edu	37	9	2651933	2651933	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr9:2651933G>A	uc003zhk.1	+	17	2792	c.2395G>A	c.(2395-2397)GCA>ACA	p.A799T	VLDLR_uc003zhl.1_Missense_Mutation_p.A771T|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Missense_Mutation_p.A730T	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	799	Helical; (Potential).				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity	p.A799T(1)		ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		GACTTCTGCCGCATGGGCCAT	0.433000													43	108					0	0	0.013114	0	0
TYRP1	7306	broad.mit.edu	37	9	12704628	12704628	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr9:12704628C>A	uc003zkv.3	+	6	1362	c.1184C>A	c.(1183-1185)CCA>CAA	p.P395Q		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	395	Lumenal, melanosome (Potential).			PN -> SQ (in Ref. 7; CAA35820).	melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		CATTTGTCTCCAAATGATCCT	0.443000									Oculocutaneous_Albinism				98	238					1.14069e-49	1.32387e-49	0.014410	1	0
C9orf24	84688	broad.mit.edu	37	9	34397497	34397497	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr9:34397497C>T	uc003zuh.1	-	1	353	c.135G>A	c.(133-135)CCG>CCA	p.P45P		NM_032596	NP_115985	Q8NCR6	CI024_HUMAN	testes development-related NYD-SP22 isoform 1	45										ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.123)		TCCCACTTACCGGAGTCAGAA	0.522000													79	187					0	0	0.014410	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396007	38396007	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr9:38396007C>T	uc004aay.2	+	2	374	c.262C>T	c.(262-264)CGC>TGC	p.R88C		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	88					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GGAAGCCTTCCGCCTGGGGTC	0.677000													19	234					0	0	0.010504	0	0
Unknown	0	broad.mit.edu	37	MT	3413	3413	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chrM:3413G>A	uc004cos.3	+	2		c.1706G>A			uc011mfh.1_5'Flank					Homo sapiens mRNA expressed only in placental villi, clone SMAP47.																		ACTACGCAAAGGCCCCAACGT	0.488000													14	11					0	0	0.003163	0	0
Unknown	0	broad.mit.edu	37	MT	12957	12957	+	RNA	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chrM:12957T>C	uc004cox.3	+	1		c.621T>C			uc004coy.2_5'Flank					Homo sapiens NADH dehydrogenase subunit 5 (MTND5) mRNA, RNA 5, complete cds; mitochondrial gene for mitochondrial product.																		CTAAACGCTAATCCAAGCCTC	0.522000													30	12					0	0	0.010818	0	0
ATRX	546	broad.mit.edu	37	X	76939481	76939481	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chrX:76939481C>G	uc004ecp.3	-	9	1499	c.1267G>C	c.(1267-1269)GTA>CTA	p.V423L	ATRX_uc004ecq.3_Missense_Mutation_p.V385L|ATRX_uc004eco.3_Missense_Mutation_p.V208L|ATRX_uc004ecr.2_Missense_Mutation_p.V384L|ATRX_uc010nlx.1_Missense_Mutation_p.V423L|ATRX_uc010nly.1_Missense_Mutation_p.V368L	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	423					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCTTTGTTTACAGCATCCATC	0.378000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						4	306					0	0	0.009096	0	0
STAG2	10735	broad.mit.edu	37	X	123176469	123176469	+	Nonsense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chrX:123176469C>T	uc004etz.3	+	6	775	c.436C>T	c.(436-438)CGA>TGA	p.R146*	STAG2_uc004eua.2_Nonsense_Mutation_p.R146*|STAG2_uc004eub.2_Nonsense_Mutation_p.R146*|STAG2_uc004euc.2_Nonsense_Mutation_p.R146*|STAG2_uc004eud.2_Nonsense_Mutation_p.R146*|STAG2_uc004eue.2_Nonsense_Mutation_p.R146*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	146					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGAGATAATTCGAAAAATGAC	0.284000													72	10					0	0	0.014410	0	0
IL9R	3581	broad.mit.edu	37	X	155232601	155232601	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chrX:155232601G>A	uc004fnv.1	+	2	238	c.59G>A	c.(58-60)CGA>CAA	p.R20Q	IL9R_uc010nvn.2_5'UTR|IL9R_uc004fnu.1_Missense_Mutation_p.R67Q	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	20					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCCCTGAGGCGAGACATGGGC	0.612000													71	128					0	0	0.014410	0	0
SDF4	51150	broad.mit.edu	37	1	1153925	1153925	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:1153925G>A	uc001adh.3	-	6	1154	c.825C>T	c.(823-825)GAC>GAT	p.D275D	SDF4_uc001adg.2_RNA|SDF4_uc001adi.3_Silent_p.D275D|SDF4_uc009vjv.2_Silent_p.D153D|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	275					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		CCCAGTTGTCGTCAATGTCCT	0.607000													8	173					0	0	0.004482	0	0
CCNL2	81669	broad.mit.edu	37	1	1334456	1334456	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:1334456G>A	uc001afi.2	-	1	263	c.231C>T	c.(229-231)CTC>CTT	p.L77L	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Silent_p.L77L|CCNL2_uc001afj.2_Silent_p.L77L|CCNL2_uc001afk.2_Silent_p.L77L|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	77					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CCACCACGCGGAGGTCGGTCT	0.692000													17	34					0	0	0.016522	0	0
CCNL2	81669	broad.mit.edu	37	1	1334592	1334592	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:1334592G>A	uc001afi.2	-	1	127	c.95C>T	c.(94-96)TCG>TTG	p.S32L	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Missense_Mutation_p.S32L|CCNL2_uc001afj.2_Missense_Mutation_p.S32L|CCNL2_uc001afk.2_Missense_Mutation_p.S32L|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	32					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CACCCCCTGCGACCCTGAGGG	0.607000													28	34					0	0	0.010818	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6528353	6528353	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:6528353C>T	uc001ano.1	-	21	2812	c.2711G>A	c.(2710-2712)CGA>CAA	p.R904Q	PLEKHG5_uc001ann.1_Missense_Mutation_p.R885Q|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Missense_Mutation_p.R925Q|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Missense_Mutation_p.R409Q|PLEKHG5_uc009vma.1_Missense_Mutation_p.R688Q|PLEKHG5_uc010nzr.1_Missense_Mutation_p.R917Q|PLEKHG5_uc001ank.1_Missense_Mutation_p.R848Q|PLEKHG5_uc009vmb.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anl.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anm.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anr.1_Missense_Mutation_p.R111Q	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	904					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GGAAGGAACTCGTGGGGACTC	0.662000													9	12					0	0	0.004482	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854436	12854436	+	Silent	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:12854436G>C	uc001auj.1	+	3	763	c.660G>C	c.(658-660)CTG>CTC	p.L220L		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	220											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCACGTCTGATAAGAAAGC	0.393000													326	349					0	0	0.014410	0	0
THRAP3	9967	broad.mit.edu	37	1	36748232	36748232	+	Missense_Mutation	SNP	G	A	A	rs148045717		TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:36748232G>A	uc001cae.3	+	3	292	c.68G>A	c.(67-69)CGT>CAT	p.R23H	THRAP3_uc001caf.3_Missense_Mutation_p.R23H|THRAP3_uc001cag.1_Missense_Mutation_p.R23H	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	23	Arg-rich.|Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCAAGATCTCGTTCTCGTTCA	0.453000			T	USP6	aneurysmal bone cysts								77	86					0	0	0.014410	0	0
MACF1	23499	broad.mit.edu	37	1	39910503	39910503	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:39910503G>C	uc010oiu.1	+	45	15061	c.14930G>C	c.(14929-14931)AGA>ACA	p.R4977T	MACF1_uc010ois.1_Missense_Mutation_p.R4475T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6542	Spectrin 14.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATGGAAGAAAGAAAGGTACAG	0.418000													33	32					0	0	0.015359	0	0
ST7L	54879	broad.mit.edu	37	1	113126670	113126670	+	Silent	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:113126670T>C	uc001ecd.2	-	7	1085	c.780A>G	c.(778-780)GCA>GCG	p.A260A	ST7L_uc009wgh.2_Intron|ST7L_uc001ecc.2_Silent_p.A77A|ST7L_uc010owg.1_Silent_p.A195A|ST7L_uc010owh.1_Intron|ST7L_uc001ece.2_Silent_p.A260A|ST7L_uc001ecf.2_Silent_p.A243A|ST7L_uc001ecg.2_RNA|ST7L_uc010owi.1_Silent_p.A195A|ST7L_uc001ech.2_Silent_p.A243A|ST7L_uc001eci.2_Silent_p.A260A|ST7L_uc009wgi.1_RNA|ST7L_uc010owj.1_Silent_p.A243A	NM_017744	NP_060214	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7-like isoform 1	260					negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGCCTTGAGTGCCTGTTTAA	0.433000													75	75					0	0	0.014410	0	0
ATP1A1	476	broad.mit.edu	37	1	116931284	116931284	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:116931284G>A	uc001ege.2	+	6	865	c.526G>A	c.(526-528)GAG>AAG	p.E176K	ATP1A1_uc010owv.1_Missense_Mutation_p.E145K|ATP1A1_uc010oww.1_Missense_Mutation_p.E176K|ATP1A1_uc010owx.1_Missense_Mutation_p.E145K	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	176	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TCGAAATGGTGAGAAAATGAG	0.398000													86	115					0	0	0.014410	0	0
LOC200030	200030	broad.mit.edu	37	1	148025786	148025786	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:148025786G>A	uc001eqf.2	-	7	1101	c.1066C>T	c.(1066-1068)CAG>TAG	p.Q356*	LOC200030_uc001eqe.2_5'UTR|LOC200030_uc001eqg.2_5'UTR|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Nonsense_Mutation_p.Q16*|NBPF14_uc001eqs.1_5'Flank	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	356	Potential.					cytoplasm					0						TGCTTGAGCTGCTCTGCAAGC	0.527000													81	323					0	0	0.014410	0	0
LOC200030	200030	broad.mit.edu	37	1	148025829	148025829	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:148025829C>T	uc001eqf.2	-	7	1058	c.1023G>A	c.(1021-1023)ATG>ATA	p.M341I	LOC200030_uc001eqe.2_5'UTR|LOC200030_uc001eqg.2_5'UTR|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Missense_Mutation_p.M1I|NBPF14_uc001eqs.1_5'Flank	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	341	Potential.					cytoplasm					0						CATTCCTCAGCATAGATTTTA	0.532000													135	459					0	0	0.014410	0	0
SHE	126669	broad.mit.edu	37	1	154474217	154474217	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:154474217C>T	uc001ffb.2	-	1	373	c.286G>A	c.(286-288)GTC>ATC	p.V96I	SHE_uc001ffc.2_RNA|TDRD10_uc001ffd.2_5'Flank|TDRD10_uc009wow.2_5'Flank	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	96										breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TTGGGGCCGACGCCGGCCCTG	0.731000													4	3					0	0	0.004482	0	0
TDRD10	126668	broad.mit.edu	37	1	154493835	154493835	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:154493835G>A	uc009wow.2	+	6	1087	c.249G>A	c.(247-249)GTG>GTA	p.V83V	TDRD10_uc001ffd.2_Silent_p.V83V|TDRD10_uc001ffe.2_Silent_p.V4V	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	83	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGCAGAAAGTGACACTTGCAA	0.502000													58	331					0	0	0.014410	0	0
XPR1	9213	broad.mit.edu	37	1	180849312	180849312	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:180849312G>C	uc001goi.2	+	14	2101	c.1909G>C	c.(1909-1911)GAT>CAT	p.D637H	XPR1_uc009wxn.2_Missense_Mutation_p.D572H	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	637	EXS.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						CCTGAACGCAGATGATCAGAC	0.517000													45	65					0	0	0.014410	0	0
LRRN2	10446	broad.mit.edu	37	1	204587907	204587907	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:204587907C>T	uc001hbe.1	-	3	1602	c.1214G>A	c.(1213-1215)CGC>CAC	p.R405H	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.R405H|LRRN2_uc009xbf.1_Missense_Mutation_p.R405H|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	405	Extracellular (Potential).|LRRCT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GACCGGGAGGCGCTGGAGGTC	0.662000													7	78					0	0	0.008291	0	0
SLC26A9	115019	broad.mit.edu	37	1	205888030	205888030	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:205888030C>T	uc001hdq.2	-	19	2308	c.2194G>A	c.(2194-2196)GAC>AAC	p.D732N	SLC26A9_uc001hdm.2_5'Flank|SLC26A9_uc001hdn.2_5'Flank|SLC26A9_uc001hdo.2_Missense_Mutation_p.D400N|SLC26A9_uc001hdp.2_Missense_Mutation_p.D732N	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	732	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGGACTGCGTCATGTATGCTG	0.517000											OREG0014164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	288	347					0	0	0.014410	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49667829	49667829	+	Missense_Mutation	SNP	C	T	T	rs75710233	byFrequency	TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr10:49667829C>T	uc001jgt.2	-	5	854	c.557G>A	c.(556-558)CGC>CAC	p.R186H	ARHGAP22_uc001jgs.2_Missense_Mutation_p.R96H|ARHGAP22_uc001jgu.2_Missense_Mutation_p.R202H|ARHGAP22_uc010qgl.1_Missense_Mutation_p.R143H|ARHGAP22_uc010qgm.1_Missense_Mutation_p.R192H|ARHGAP22_uc001jgv.2_5'UTR	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	186	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						AGTGAGCCCGCGCTCCCGGAT	0.642000													66	152					0	0	0.014410	0	0
SGMS1	259230	broad.mit.edu	37	10	52071078	52071078	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr10:52071078T>C	uc001jje.2	-	9	1793	c.839A>G	c.(838-840)TAT>TGT	p.Y280C	SGMS1_uc010qhk.1_Missense_Mutation_p.Y111C|SGMS1_uc009xot.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	286	Helical; (Potential).				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						GCTGTACAGATAGTCCCCACA	0.453000													27	39					0	0	0.007291	0	0
IDE	3416	broad.mit.edu	37	10	94297234	94297234	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr10:94297234G>C	uc001kia.2	-	2	248	c.172C>G	c.(172-174)CCT>GCT	p.P58A		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	58					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTCTTCAGGAGACTTGGTA	0.388000													108	114					0	0	0.014410	0	0
RIC8A	60626	broad.mit.edu	37	11	209483	209483	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:209483T>A	uc001log.2	+	3	534	c.209T>A	c.(208-210)GTC>GAC	p.V70D	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Missense_Mutation_p.V70D|RIC8A_uc001loh.2_Missense_Mutation_p.V63D	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	70						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTGCAGAGTGTCCGAATCCTG	0.642000													33	109					0	0	0.009718	0	0
APLNR	187	broad.mit.edu	37	11	57004337	57004337	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:57004337G>C	uc001njo.2	-	1	591	c.142C>G	c.(142-144)CTG>GTG	p.L48V	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	48	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						CAGAGCACCAGACCGTTGCCC	0.592000													71	105					0	0	0.014410	0	0
MS4A15	219995	broad.mit.edu	37	11	60540926	60540926	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:60540926T>A	uc009ynf.1	+	5	687	c.467T>A	c.(466-468)ATT>AAT	p.I156N	MS4A15_uc001npx.2_Missense_Mutation_p.I63N|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Missense_Mutation_p.I115N	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	156	Helical; (Potential).					integral to membrane	receptor activity			lung(1)	1						GGGACAGCCATTCTGCTCATG	0.572000													27	22					0	0	0.019004	0	0
VWCE	220001	broad.mit.edu	37	11	61026184	61026184	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:61026184G>A	uc001nra.2	-	20	3110	c.2831C>T	c.(2830-2832)CCA>CTA	p.P944L	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	944						extracellular region	calcium ion binding			ovary(1)	1						AGCCCCCACTGGGGGCTGCTG	0.662000													41	164					0	0	0.014410	0	0
STARD10	10809	broad.mit.edu	37	11	72470333	72470333	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:72470333C>G	uc001osy.2	-	3	592	c.301G>C	c.(301-303)GAG>CAG	p.E101Q	ARAP1_uc001osv.2_Intron|STARD10_uc001osz.3_Missense_Mutation_p.E101Q|STARD10_uc001ota.2_Missense_Mutation_p.E55Q|STARD10_uc001otb.2_Missense_Mutation_p.E101Q	NM_006645	NP_006636	Q9Y365	PCTL_HUMAN	START domain containing 10	101	START.										0			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			TCAAAAGTCTCAATGACGTTG	0.562000													47	70					0	0	0.014410	0	0
ARRB1	408	broad.mit.edu	37	11	74985127	74985127	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:74985127G>C	uc001owe.1	-	11	1127	c.905C>G	c.(904-906)TCT>TGT	p.S302C	ARRB1_uc001owf.1_Missense_Mutation_p.S302C	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	302					G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						CAGGGTGCTAGAGGCCAAGTT	0.602000													180	212					0	0	0.014410	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48142257	48142257	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr12:48142257G>A	uc009zkp.2	-	11	1537	c.1097C>T	c.(1096-1098)TCC>TTC	p.S366F	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Missense_Mutation_p.S366F|RAPGEF3_uc001rpz.3_Missense_Mutation_p.S408F|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Missense_Mutation_p.S420F	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	366					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		ATGAGCACTGGAATCTGGTCC	0.478000													42	57					0	0	0.014410	0	0
MLL2	8085	broad.mit.edu	37	12	49425839	49425839	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr12:49425839G>A	uc001rta.3	-	39	12649	c.12649C>T	c.(12649-12651)CAG>TAG	p.Q4217*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4217	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGCTGCTGCTGAGGACTTAAG	0.622000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			22	40					0	0	0.012213	0	0
MLL2	8085	broad.mit.edu	37	12	49426526	49426526	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr12:49426526G>A	uc001rta.3	-	39	11962	c.11962C>T	c.(11962-11964)CAG>TAG	p.Q3988*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3988	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGTTGTTGCTGAGGAGACAGT	0.378000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			16	11					0	0	0.024245	0	0
HSP90B1	7184	broad.mit.edu	37	12	104327895	104327895	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr12:104327895G>C	uc001tkb.1	+	5	678	c.573G>C	c.(571-573)TTG>TTC	p.L191F	HSP90B1_uc010swg.1_Intron|HSP90B1_uc009zui.1_Missense_Mutation_p.L191F	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	191					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CTTCTGAATTGATTGGCCAGT	0.428000													6	190					0	0	0.006214	0	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	T	T	rs144465613	byFrequency	TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:23887583C>T	uc001wjx.2	-	30	4111	c.4005G>A	c.(4003-4005)TCG>TCA	p.S1335S	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													4	96					0	0	0.001984	0	0
INSM2	84684	broad.mit.edu	37	14	36005048	36005048	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:36005048C>T	uc001wth.1	+	1	1801	c.1590C>T	c.(1588-1590)TGC>TGT	p.C530C		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	530	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		GCAAGCACTGCCCGTCCACTT	0.627000													21	102					0	0	0.010504	0	0
FKBP3	2287	broad.mit.edu	37	14	45603575	45603575	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:45603575G>A	uc010tqf.1	-	1	158	c.85C>T	c.(85-87)CTG>TTG	p.L29L	FANCM_uc001wwc.2_5'Flank|FANCM_uc001wwd.3_5'Flank|FANCM_uc010anf.2_5'Flank	NM_002013	NP_002004	Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	29					protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity				0						TGTTCCTGCAGAAACTTGATA	0.652000													80	110					0	0	0.014410	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256349	69256349	+	Silent	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:69256349C>G	uc001xkh.1	-	2	1048	c.918G>C	c.(916-918)CTG>CTC	p.L306L	ZFP36L1_uc001xki.1_Silent_p.L306L	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	306					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TGGAGCTGCTCAGGTAGCCCT	0.597000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	89	124					0	0	0.014410	0	0
MLH3	27030	broad.mit.edu	37	14	75514890	75514890	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:75514890G>C	uc001xrd.1	-	2	1685	c.1469C>G	c.(1468-1470)TCT>TGT	p.S490C	MLH3_uc001xre.1_Missense_Mutation_p.S490C|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	490					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TTCCAGGAAAGATTTTTTATG	0.378000								MMR					60	93					0	0	0.014410	0	0
PPP2R5C	5527	broad.mit.edu	37	14	102391505	102391505	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:102391505C>G	uc001yko.2	+	14	1611	c.1471C>G	c.(1471-1473)CCT>GCT	p.P491A	PPP2R5C_uc010txr.1_Missense_Mutation_p.P522A|PPP2R5C_uc001ykk.2_Missense_Mutation_p.P507A|PPP2R5C_uc001ykp.2_Missense_Mutation_p.P452A	NM_002719	NP_002710	Q13362	2A5G_HUMAN	gamma isoform of regulatory subunit B56, protein	491					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity			ovary(1)|breast(1)	2						GAAGGACCGTCCTCTTGCACG	0.552000													7	474					0	0	0.004482	0	0
SNORD116-1	100033413	broad.mit.edu	37	15	25296712	25296712	+	RNA	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:25296712G>C	uc001yxg.2	+	1		c.90G>C				NR_003316				Homo sapiens small nucleolar RNA, C/D box 116-1 (SNORD116-1), non-coding RNA.												0						CATCGGAACTGAGGTCCAGCA	0.473000													83	132					0	0	0.014410	0	0
GABRB3	2562	broad.mit.edu	37	15	26793190	26793190	+	Nonsense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:26793190G>C	uc001zaz.2	-	9	1314	c.1172C>G	c.(1171-1173)TCA>TGA	p.S391*	GABRB3_uc010uae.1_Nonsense_Mutation_p.S306*|GABRB3_uc001zba.2_Nonsense_Mutation_p.S391*|GABRB3_uc001zbb.2_Nonsense_Mutation_p.S447*	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	391	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGATATTGCTGAATTCCTGGT	0.493000													98	128					0	0	0.014410	0	0
APBA2	321	broad.mit.edu	37	15	29368274	29368274	+	Nonsense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:29368274C>A	uc001zck.2	+	5	1256	c.1049C>A	c.(1048-1050)TCA>TAA	p.S350*	APBA2_uc010azj.2_Nonsense_Mutation_p.S350*|APBA2_uc010uat.1_Nonsense_Mutation_p.S350*|APBA2_uc001zcl.2_Nonsense_Mutation_p.S350*|APBA2_uc001zcm.1_Nonsense_Mutation_p.S54*	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	350					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		AAGGTGGCATCATTTCCAAGT	0.373000													9	322					0.00185496	0.00206397	0.016723	1	0
TYRO3	7301	broad.mit.edu	37	15	41859568	41859568	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:41859568C>A	uc001zof.1	+	7	1018	c.794C>A	c.(793-795)GCC>GAC	p.A265D		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	265	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.A265G(1)		ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GTGACACAGGCCCCAGGAGGC	0.557000													8	250					0.00448238	0.00495256	0.004482	1	0
DMXL2	23312	broad.mit.edu	37	15	51857284	51857284	+	Splice_Site	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:51857284C>A	uc002abf.2	-	4	589	c.364_splice	c.e4+1	p.D122_splice	DMXL2_uc010ufy.1_Splice_Site_p.D122_splice|DMXL2_uc010bfa.2_Splice_Site_p.D122_splice	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2							cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TTGCTAAATACCTTGAGGATC	0.289000													6	9					3.59834e-05	4.09019e-05	0.021553	1	0
MCTP2	55784	broad.mit.edu	37	15	95019963	95019963	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:95019963T>C	uc002btj.2	+	21	2574	c.2509T>C	c.(2509-2511)TCC>CCC	p.S837P	MCTP2_uc010boj.2_Missense_Mutation_p.S566P|MCTP2_uc010bok.2_Missense_Mutation_p.S782P|MCTP2_uc002btl.2_Missense_Mutation_p.S425P	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	837					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAATCCCTATTCCATCGACAA	0.323000													6	187					0	0	0.001984	0	0
MCTP2	55784	broad.mit.edu	37	15	95019965	95019965	+	Silent	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:95019965C>A	uc002btj.2	+	21	2576	c.2511C>A	c.(2509-2511)TCC>TCA	p.S837S	MCTP2_uc010boj.2_Silent_p.S566S|MCTP2_uc010bok.2_Silent_p.S782S|MCTP2_uc002btl.2_Silent_p.S425S	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	837					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			ATCCCTATTCCATCGACAATA	0.323000													6	192					2.0095e-06	2.30073e-06	0.001984	1	0
SYNM	23336	broad.mit.edu	37	15	99670884	99670884	+	Silent	SNP	C	G	G	rs112125623		TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:99670884C>G	uc002bup.2	+	6	2439	c.2319C>G	c.(2317-2319)GTC>GTG	p.V773V	SYNM_uc002buo.2_Silent_p.V773V|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	773	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						TGGAGGAGGTCGAAGATGTGT	0.547000													3	65					0	0	0.004672	0	0
GGA2	23062	broad.mit.edu	37	16	23503028	23503028	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:23503028G>C	uc002dlq.2	-	5	521	c.445C>G	c.(445-447)CGA>GGA	p.R149G	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	149	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		TAAGCGTCTCGAATCTTGATG	0.353000													8	367					0	0	0.006214	0	0
WDR59	79726	broad.mit.edu	37	16	74990405	74990405	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:74990405G>A	uc002fdh.1	-	3	310	c.208C>T	c.(208-210)CAT>TAT	p.H70Y	WDR59_uc002fdi.2_Missense_Mutation_p.H70Y|WDR59_uc002fdj.2_Missense_Mutation_p.H70Y	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	70	WD 1.									ovary(1)|breast(1)	2						AAGCTGTCATGAGGATTCCAC	0.468000													54	76					0	0	0.014410	0	0
ZDHHC7	55625	broad.mit.edu	37	16	85010706	85010706	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:85010706C>T	uc002fiq.2	-	7	1098	c.745G>A	c.(745-747)GAG>AAG	p.E249K	ZDHHC7_uc010voi.1_Missense_Mutation_p.E286K|ZDHHC7_uc002fir.1_RNA	NM_017740	NP_060210	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7 isoform 2	249						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(1)	1						CTTACCGTCTCGTCGTTGCAT	0.448000													128	156					0	0	0.014410	0	0
ITGAE	3682	broad.mit.edu	37	17	3659152	3659152	+	Missense_Mutation	SNP	A	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:3659152A>T	uc002fwo.3	-	11	1310	c.1211T>A	c.(1210-1212)ATT>AAT	p.I404N		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	404	FG-GAP 3.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		ACTGAAGCCAATCTGTGCCAG	0.592000													3	12					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7579415	7579415	+	Nonsense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:7579415C>T	uc002gim.2	-	4	466	c.272G>A	c.(271-273)TGG>TAG	p.W91*	TP53_uc002gig.1_Nonsense_Mutation_p.W91*|TP53_uc002gih.2_Nonsense_Mutation_p.W91*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.W91*|TP53_uc010cni.1_Nonsense_Mutation_p.W91*|TP53_uc002gij.2_Nonsense_Mutation_p.W91*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.W52*|TP53_uc010cnk.1_Nonsense_Mutation_p.W106*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	91	Interaction with WWOX.		W -> C (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W91*(11)|p.0?(7)|p.G59fs*23(3)|p.V73fs*9(1)|p.D48fs*55(1)|p.W91fs*57(1)|p.A88fs*52(1)|p.W91fs*13(1)|p.P87fs*54(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGACAGGGGCCAGGAGGGGGC	0.632000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	134					0	0	0.008871	0	0
MYH13	8735	broad.mit.edu	37	17	10216500	10216500	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:10216500G>A	uc002gmk.1	-	30	4246	c.4156C>T	c.(4156-4158)CGC>TGC	p.R1386C		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1386	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCCTCTGTGCGCTGAATGGCG	0.617000													8	341					0	0	0.008291	0	0
KRT13	3860	broad.mit.edu	37	17	39659037	39659037	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:39659037T>A	uc002hwu.1	-	5	988	c.925A>T	c.(925-927)ACC>TCC	p.T309S	KRT13_uc002hwv.1_Missense_Mutation_p.T309S|KRT13_uc002hww.2_Missense_Mutation_p.T202S|KRT13_uc010wfr.1_Missense_Mutation_p.T202S|KRT13_uc010cxo.2_Missense_Mutation_p.T309S|KRT13_uc002hwx.1_Missense_Mutation_p.T297S	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	309	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GCAGTGTTGGTAGACACCTCC	0.577000													212	254					0	0	0.014410	0	0
DBF4B	80174	broad.mit.edu	37	17	42828063	42828063	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:42828063C>T	uc002ihf.2	+	14	1503	c.1290C>T	c.(1288-1290)CTC>CTT	p.L430L	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	430					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				CCACAACCCTCCTGCCGGCCT	0.617000													59	80					0	0	0.014410	0	0
EPN3	55040	broad.mit.edu	37	17	48615544	48615544	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:48615544G>A	uc002ira.3	+	3	1102	c.667G>A	c.(667-669)GAG>AAG	p.E223K	EPN3_uc010wms.1_Missense_Mutation_p.E278K|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.E223K	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	223	UIM 1.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CATGAGCCGTGAGGAGGCAGA	0.667000													16	23					0	0	0.016522	0	0
EPN3	55040	broad.mit.edu	37	17	48616322	48616322	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:48616322G>C	uc002ira.3	+	4	1194	c.759G>C	c.(757-759)GAG>GAC	p.E253D	EPN3_uc010wms.1_Intron|EPN3_uc010wmt.1_Intron|EPN3_uc010wmu.1_Intron	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	253	UIM 2.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AGGAGCACGAGAAGGTAGTGG	0.687000													3	12					0	0	0.014758	0	0
SPATA20	64847	broad.mit.edu	37	17	48628090	48628090	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:48628090G>A	uc002irf.2	+	10	1288	c.1147G>A	c.(1147-1149)GAA>AAA	p.E383K	SPATA20_uc002irc.2_Missense_Mutation_p.E50K|SPATA20_uc002ire.2_Missense_Mutation_p.E339K|SPATA20_uc002ird.2_Missense_Mutation_p.E399K|SPATA20_uc010wmv.1_3'UTR|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	383					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CTATAGCGCAGAAGATGCAGA	0.672000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	168	181					0	0	0.014410	0	0
SPATA20	64847	broad.mit.edu	37	17	48628385	48628385	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:48628385G>A	uc002irf.2	+	11	1503	c.1362G>A	c.(1360-1362)CAG>CAA	p.Q454Q	SPATA20_uc002irc.2_Silent_p.Q121Q|SPATA20_uc002ire.2_Silent_p.Q410Q|SPATA20_uc002ird.2_Silent_p.Q470Q|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	454					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			TGCAGGGCCAGAATGTGCTGA	0.637000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	65					0	0	0.014410	0	0
TEX2	55852	broad.mit.edu	37	17	62238165	62238165	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:62238165C>G	uc002jec.2	-	8	2973	c.2800G>C	c.(2800-2802)GAA>CAA	p.E934Q	TEX2_uc002jed.2_Missense_Mutation_p.E941Q|TEX2_uc002jee.2_Missense_Mutation_p.E934Q	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	934					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CCTTACCCTTCTTTGCCAATT	0.463000													577	239					0	0	0.014410	0	0
CACNG4	27092	broad.mit.edu	37	17	65026963	65026963	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:65026963T>C	uc002jft.1	+	4	842	c.827T>C	c.(826-828)ATG>ACG	p.M276T		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	276	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			GAGCTGTCCATGTACACGCTG	0.647000													36	141					0	0	0.010771	0	0
SLC38A10	124565	broad.mit.edu	37	17	79249777	79249777	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:79249777C>T	uc002jzz.1	-	8	1279	c.904G>A	c.(904-906)GAG>AAG	p.E302K	SLC38A10_uc002jzy.1_Missense_Mutation_p.E220K|SLC38A10_uc002kab.2_Missense_Mutation_p.E302K	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	302					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ACCTGCTGCTCACACAGCAGC	0.597000													81	309					0	0	0.014410	0	0
DSC2	1824	broad.mit.edu	37	18	28660162	28660162	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr18:28660162G>C	uc002kwl.3	-	10	1874	c.1420C>G	c.(1420-1422)CCA>GCA	p.P474A	DSC2_uc002kwk.3_Missense_Mutation_p.P474A	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	474	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GTCTGTATTGGAGGGTTACAC	0.443000													154	125					0	0	0.014410	0	0
C19orf21	126353	broad.mit.edu	37	19	757669	757669	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:757669C>T	uc002lpo.2	+	2	806	c.723C>T	c.(721-723)AAC>AAT	p.N241N		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	241										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTGGCCAACGGGCACGTGG	0.672000													30	24					0	0	0.010818	0	0
PIK3R2	5296	broad.mit.edu	37	19	18279617	18279617	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:18279617G>A	uc002nia.1	+	15	2402	c.1890G>A	c.(1888-1890)ACG>ACA	p.T630T	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	630	SH2 2.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						TCAACCGCACGCAGGCAGAGG	0.657000											OREG0025359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	30					0	0	0.013726	0	0
CYP2S1	29785	broad.mit.edu	37	19	41709523	41709523	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:41709523G>A	uc002opw.2	+	7	1200	c.1145G>A	c.(1144-1146)CGA>CAA	p.R382Q	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Missense_Mutation_p.R107Q	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	382					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						ACCCGCTTCCGAGGGTACACC	0.667000													4	5					0	0	0.014758	0	0
LMTK3	114783	broad.mit.edu	37	19	49001422	49001422	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:49001422C>A	uc002pjk.2	-	12	2991	c.2991G>T	c.(2989-2991)AGG>AGT	p.R997S		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		TCTCCTCCCTCCTTGGGGGTG	0.647000													12	295					2.27111e-07	2.6385e-07	0.013537	1	0
LMTK3	114783	broad.mit.edu	37	19	49001524	49001524	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:49001524C>G	uc002pjk.2	-	12	2889	c.2889G>C	c.(2887-2889)CAG>CAC	p.Q963H		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTGGGGCTCTCTGGTCCCCGT	0.647000													6	100					0	0	0.021553	0	0
PRR12	57479	broad.mit.edu	37	19	50099849	50099849	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:50099849G>A	uc002poo.3	+	4	2257	c.2257G>A	c.(2257-2259)GCC>ACC	p.A753T		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CGGGGCAGGCGCCAAGGAGCT	0.692000													11	11					0	0	0.008291	0	0
ETAA1	54465	broad.mit.edu	37	2	67631299	67631299	+	Silent	SNP	A	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:67631299A>G	uc002sdz.1	+	5	1624	c.1485A>G	c.(1483-1485)CAA>CAG	p.Q495Q		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	495						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						ACGAAATTCAAAATTGTATAG	0.279000													4	11					0	0	0.009096	0	0
WDR54	84058	broad.mit.edu	37	2	74652604	74652604	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:74652604A>G	uc002slb.2	+	9	919	c.859A>G	c.(859-861)AGT>GGT	p.S287G		NM_032118	NP_115494	Q9H977	WDR54_HUMAN	WD repeat domain 54	287	WD 4.										0						AAACCCAGAGAGTGGCTACAT	0.597000													3	153					0	0	0.009096	0	0
AFF3	3899	broad.mit.edu	37	2	100623250	100623250	+	Silent	SNP	G	A	A	rs138844530	by1000genomes	TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:100623250G>A	uc002tag.2	-	6	953	c.717C>T	c.(715-717)GAC>GAT	p.D239D	AFF3_uc002taf.2_Silent_p.D264D|AFF3_uc010fiq.1_Silent_p.D239D|AFF3_uc010yvr.1_Silent_p.D393D|AFF3_uc002tah.1_Silent_p.D264D|AFF3_uc010fir.1_Silent_p.D316D|AFF3_uc002tai.2_Silent_p.D161D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	239					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GATCTTGGCCGTCCATTGGCC	0.572000													61	55					0	0	0.014410	0	0
NEB	4703	broad.mit.edu	37	2	152397247	152397247	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:152397247C>T	uc010fnx.2	-	109	15839	c.15648G>A	c.(15646-15648)TTG>TTA	p.L5216L	NEB_uc002txr.2_Silent_p.L1639L	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5216	Nebulin 142.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TAGCATGCTTCAAGGCTGTGG	0.433000													10	87					0	0	0.020292	0	0
IFIH1	64135	broad.mit.edu	37	2	163174420	163174420	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:163174420T>A	uc002uce.2	-	1	620	c.398A>T	c.(397-399)GAC>GTC	p.D133V	IFIH1_uc002ucf.2_Missense_Mutation_p.D133V	NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	133	CARD 2.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						ATCCAAGACGTCTCTAACTAG	0.483000													14	756					0	0	0.028581	0	0
CCDC108	255101	broad.mit.edu	37	2	219886640	219886640	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:219886640C>T	uc002vjl.1	-	18	3076	c.2992G>A	c.(2992-2994)GAG>AAG	p.E998K	CCDC108_uc002vjm.3_5'Flank	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	998						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGGCCAGCTCCTTTTCCTTT	0.597000													120	79					0	0	0.014410	0	0
OBSL1	23363	broad.mit.edu	37	2	220420911	220420911	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:220420911G>A	uc010fwk.2	-	14	4497	c.4440C>T	c.(4438-4440)GCC>GCT	p.A1480A	OBSL1_uc002vmh.1_Silent_p.A379A|OBSL1_uc010zli.1_Silent_p.A287A|OBSL1_uc010fwl.1_Silent_p.A955A	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1480	Ig-like 12.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CCCAGCGCACGGCCCCCGCTG	0.657000													4	13					0	0	0.021553	0	0
CPXM1	56265	broad.mit.edu	37	20	2775058	2775058	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr20:2775058C>A	uc002wgu.2	-	14	2047	c.1983G>T	c.(1981-1983)TGG>TGT	p.W661C	CPXM1_uc010gas.2_Missense_Mutation_p.W587C	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	661					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						TCAGCAGACGCCAATAATCCC	0.597000													17	86					3.62473e-10	4.37181e-10	0.012319	1	0
HNF4A	3172	broad.mit.edu	37	20	43048484	43048484	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr20:43048484C>T	uc002xma.2	+	7	949	c.860C>T	c.(859-861)GCC>GTC	p.A287V	HNF4A_uc002xlt.2_Missense_Mutation_p.A265V|HNF4A_uc002xlu.2_Missense_Mutation_p.A265V|HNF4A_uc002xlv.2_Missense_Mutation_p.A265V|HNF4A_uc002xly.2_Missense_Mutation_p.A287V|HNF4A_uc002xlz.2_Missense_Mutation_p.A287V|HNF4A_uc010ggq.2_Missense_Mutation_p.A280V	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	287					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			AATGAGTATGCCTACCTCAAA	0.557000													5	234					0	0	0.021553	0	0
CTCFL	140690	broad.mit.edu	37	20	56090811	56090811	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr20:56090811C>G	uc010gix.1	-	5	1801	c.1139G>C	c.(1138-1140)AGA>ACA	p.R380T	CTCFL_uc010giw.1_Missense_Mutation_p.R380T|CTCFL_uc002xym.2_Missense_Mutation_p.R380T|CTCFL_uc010giz.1_5'UTR|CTCFL_uc010giy.1_5'UTR|CTCFL_uc010gja.1_Missense_Mutation_p.R380T|CTCFL_uc010gjb.1_Missense_Mutation_p.R380T|CTCFL_uc010gjc.1_Missense_Mutation_p.R380T|CTCFL_uc010gjd.1_Missense_Mutation_p.R380T|CTCFL_uc010gje.2_Missense_Mutation_p.R380T|CTCFL_uc010gjf.2_Missense_Mutation_p.R175T|CTCFL_uc010gjg.2_Missense_Mutation_p.R112T|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Missense_Mutation_p.R175T|CTCFL_uc010gjj.1_Missense_Mutation_p.R380T	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	380	C2H2-type 5.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GTAGGTATCTCTGCTGGCATA	0.483000													226	343					0	0	0.014410	0	0
ZBTB46	140685	broad.mit.edu	37	20	62407208	62407208	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr20:62407208G>A	uc002ygv.1	-	3	1246	c.1045C>T	c.(1045-1047)CTG>TTG	p.L349L	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GGAGGGCCCAGATAGCTGGCT	0.662000													120	128					0	0	0.014410	0	0
C21orf99	149992	broad.mit.edu	37	21	14439254	14439254	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr21:14439254G>A	uc002yja.3	+	10		c.2772G>A				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AGGAAAAATCGAAGAGCAACA	0.303000													15	21					0	0	0.028581	0	0
MB	4151	broad.mit.edu	37	22	36013290	36013290	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:36013290G>A	uc003anz.2	-	1	95	c.15C>T	c.(13-15)GAC>GAT	p.D5D	MB_uc003aoa.2_Silent_p.D5D|MB_uc003aob.2_Silent_p.D5D	NM_005368	NP_005359	P02144	MYG_HUMAN	myoglobin	5							heme binding|oxygen transporter activity				0						GCCATTCCCCGTCGCTGAGCC	0.577000													4	137					0	0	0.001984	0	0
PICK1	9463	broad.mit.edu	37	22	38470965	38470965	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:38470965C>G	uc003auq.2	+	13	1464	c.1074C>G	c.(1072-1074)TTC>TTG	p.F358L	PICK1_uc003aur.2_Missense_Mutation_p.F358L|PICK1_uc003aus.2_Missense_Mutation_p.F358L|PICK1_uc003aut.2_Missense_Mutation_p.F358L	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	358					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					CCGACGTCTTCCCCATCGAGG	0.532000													23	38					0	0	0.024334	0	0
MKL1	57591	broad.mit.edu	37	22	40814967	40814967	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:40814967G>A	uc003ayv.1	-	9	1682	c.1475C>T	c.(1474-1476)TCG>TTG	p.S492L	MKL1_uc003ayw.1_Missense_Mutation_p.S492L|MKL1_uc010gye.1_Missense_Mutation_p.S492L|MKL1_uc010gyf.1_Missense_Mutation_p.S442L	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	492					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity	p.S492S(1)		ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTGCAGTGGCGAGGCCTGCAG	0.677000			T	RBM15	acute megakaryocytic leukemia								18	54					0	0	0.007413	0	0
PARVB	29780	broad.mit.edu	37	22	44564537	44564537	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:44564537C>T	uc003ben.2	+	13	1126	c.1074C>T	c.(1072-1074)ACC>ACT	p.T358T	PARVB_uc003bem.2_Silent_p.T391T|PARVB_uc010gzn.2_Silent_p.T283T|PARVB_uc003beo.2_Silent_p.T321T	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	358	CH 2.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				ACCTGTTCACCAAGTACAAGA	0.552000													8	111					0	0	0.004482	0	0
GTSE1	51512	broad.mit.edu	37	22	46712115	46712115	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:46712115C>T	uc011aqy.1	+	7	1450	c.1238C>T	c.(1237-1239)CCC>CTC	p.P413L	GTSE1_uc011aqz.1_Missense_Mutation_p.P260L|GTSE1_uc003bhl.1_Missense_Mutation_p.P38L|GTSE1_uc003bhm.1_Missense_Mutation_p.P38L	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	394					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CTCACGGCACCCCCCTCAGCA	0.627000													5	133					0	0	0.014758	0	0
CELSR1	9620	broad.mit.edu	37	22	46930992	46930992	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:46930992G>A	uc003bhw.1	-	1	2076	c.2076C>T	c.(2074-2076)TAC>TAT	p.Y692Y		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	692	Extracellular (Potential).|Cadherin 5.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GACGAAGCTCGTAGGTGGGCT	0.642000													12	28					0	0	0.013537	0	0
LHFPL4	375323	broad.mit.edu	37	3	9547649	9547649	+	Splice_Site	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:9547649G>A	uc003bry.2	-	3	929	c.643_splice	c.e3+1	p.D215_splice		NM_198560	NP_940962	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4							integral to membrane				ovary(2)|skin(1)	3	Medulloblastoma(99;0.227)					CAGCACACTCGCCTTTGTTCT	0.592000													176	173					0	0	0.014410	0	0
EFHB	151651	broad.mit.edu	37	3	19925989	19925989	+	Silent	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:19925989G>C	uc003cbl.3	-	11	2248	c.2052C>G	c.(2050-2052)CTC>CTG	p.L684L	EFHB_uc003cbm.2_Silent_p.L554L	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	684					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						GAAGTGTCCGGAGAGTCTTTT	0.393000													64	90					0	0	0.014410	0	0
COL6A6	131873	broad.mit.edu	37	3	130287049	130287049	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:130287049G>A	uc010htl.2	+	5	2033	c.2002G>A	c.(2002-2004)GAC>AAC	p.D668N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	668	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CCAGTTCAGCGACATCAATAA	0.423000													114	153					0	0	0.014410	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	G	G	rs121913483		TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562000		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				10	16					0	0	0.004990	0	0
FGFR3	2261	broad.mit.edu	37	4	1803584	1803584	+	Silent	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:1803584C>A	uc003gdr.3	+	7	1018	c.762C>A	c.(760-762)ATC>ATA	p.I254I	FGFR3_uc003gdu.2_Silent_p.I254I|FGFR3_uc003gds.3_Silent_p.I254I|FGFR3_uc003gdq.3_Silent_p.I254I|FGFR3_uc010icb.1_Silent_p.I96I|FGFR3_uc003gdt.1_Silent_p.I96I	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	254	Ig-like C2-type 3.|Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACCGGCCCATCCTGCAGGCGG	0.557000		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				10	14					4.72057e-08	5.52482e-08	0.021523	1	0
FGFR3	2261	broad.mit.edu	37	4	1803749	1803749	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:1803749C>T	uc003gdr.3	+	7	1183	c.927C>T	c.(925-927)CTC>CTT	p.L309L	FGFR3_uc003gdu.2_Silent_p.L309L|FGFR3_uc003gds.3_Silent_p.L309L|FGFR3_uc003gdq.3_Silent_p.L309L|FGFR3_uc010icb.1_Intron|FGFR3_uc003gdt.1_Intron	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	309	Ig-like C2-type 3.|Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	TTACCGTGCTCAAGGTGGGCC	0.662000		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				11	10					0	0	0.016723	0	0
BMP2K	55589	broad.mit.edu	37	4	79832652	79832652	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:79832652G>A	uc003hlk.2	+	16	3117	c.2951G>A	c.(2950-2952)CGC>CAC	p.R984H	PAQR3_uc003hlm.2_Intron|PAQR3_uc003hln.2_Intron|uc010ijm.1_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	984						nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						CGCCAAAGGCGCACAAAGCAG	0.502000													4	122					0	0	0.014758	0	0
UNC5C	8633	broad.mit.edu	37	4	96127913	96127913	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:96127913G>T	uc003htp.1	-	11	1922	c.1768C>A	c.(1768-1770)CCT>ACT	p.P590T	UNC5C_uc010ilc.1_Missense_Mutation_p.P609T	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	590	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CTCACCACAGGGGTCAAAAGT	0.537000													20	96					4.35082e-09	5.16864e-09	0.010504	1	0
EXOSC9	5393	broad.mit.edu	37	4	122722582	122722582	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:122722582G>A	uc003iea.2	+	1	111	c.3G>A	c.(1-3)ATG>ATA	p.M1I	EXOSC9_uc003idz.2_Missense_Mutation_p.M1I|EXOSC9_uc003ieb.2_5'Flank	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	1	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						CCAACACCATGAAGGAAACGC	0.607000													74	94					0	0	0.014410	0	0
TRIML1	339976	broad.mit.edu	37	4	189068521	189068521	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:189068521G>A	uc003izm.1	+	6	1517	c.1402G>A	c.(1402-1404)GTC>ATC	p.V468I	TRIML1_uc003izn.1_Missense_Mutation_p.V192I	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	468	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GAACAGCCACGTCTGAGGGGC	0.542000													23	37					0	0	0.014410	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725009	140725009	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:140725009C>T	uc003ljm.1	+	1	1409	c.1409C>T	c.(1408-1410)TCC>TTC	p.S470F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.S230F|PCDHGA3_uc011dap.1_Missense_Mutation_p.S470F	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	470	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGAGCCTCCATCTTCTCA	0.547000													150	126					0	0	0.014410	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811015	140811015	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:140811015T>C	uc003lkt.1	+	1	858	c.689T>C	c.(688-690)GTG>GCG	p.V230A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.V230A	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	230	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCATCCGCGTGATGGTTCTG	0.657000													57	78					0	0	0.014410	0	0
CLINT1	9685	broad.mit.edu	37	5	157240138	157240138	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:157240138C>G	uc003lxj.1	-	5	640	c.450G>C	c.(448-450)AAG>AAC	p.K150N	CLINT1_uc003lxi.1_Missense_Mutation_p.K132N|CLINT1_uc011ddv.1_Missense_Mutation_p.K150N	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	150					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTTTGCTTTCTTTCGCTCTT	0.423000													54	54					0	0	0.014410	0	0
NSD1	64324	broad.mit.edu	37	5	176710832	176710832	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:176710832C>G	uc003mfr.3	+	20	6192	c.6054C>G	c.(6052-6054)TTC>TTG	p.F2018L	NSD1_uc003mft.3_Missense_Mutation_p.F1749L|NSD1_uc011dfx.1_Missense_Mutation_p.F1666L	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2018	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ATGCTCGGTTCATGAATCATT	0.453000			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			3	148					0	0	0.004672	0	0
DBN1	1627	broad.mit.edu	37	5	176895847	176895847	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:176895847C>G	uc003mgy.2	-	2	312	c.140G>C	c.(139-141)GGA>GCA	p.G47A	DBN1_uc003mgx.2_Missense_Mutation_p.G49A|DBN1_uc010jkn.1_5'UTR|DBN1_uc003mgz.1_5'UTR	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	47	ADF-H.				actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATTCCTACCTCCTGATGCTGC	0.612000													5	158					0	0	0.003080	0	0
FLT4	2324	broad.mit.edu	37	5	180048230	180048230	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:180048230C>T	uc003mma.3	-	14	2122	c.2043G>A	c.(2041-2043)ACG>ACA	p.T681T	FLT4_uc003mlz.3_Silent_p.T681T|FLT4_uc003mmb.1_Silent_p.T214T|FLT4_uc011dgy.1_Silent_p.T681T	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	681	Ig-like C2-type 7.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCAAGTTCTGCGTGAGCCGAG	0.637000									Congenital_Hereditary_Lymphedema				53	45					0	0	0.014410	0	0
OR14J1	442191	broad.mit.edu	37	6	29274483	29274483	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:29274483C>T	uc011dln.1	+	1	17	c.17C>T	c.(16-18)TCA>TTA	p.S6L		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AATTTGACTTCAATGAGTGGA	0.403000													41	41					0	0	0.009718	0	0
BRD2	6046	broad.mit.edu	37	6	32945959	32945959	+	Silent	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:32945959C>G	uc003ocn.3	+	10	3336	c.1635C>G	c.(1633-1635)CCC>CCG	p.P545P	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.P545P|BRD2_uc003ocp.3_Silent_p.P425P|BRD2_uc010juh.2_Silent_p.P545P	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	545	Arg/Lys-rich (highly basic).				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TATCCAAGCCCAAGAGGAAAA	0.463000													52	61					0	0	0.014410	0	0
BRD2	6046	broad.mit.edu	37	6	32947799	32947799	+	Nonsense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:32947799C>G	uc003ocn.3	+	11	3737	c.2036C>G	c.(2035-2037)TCA>TGA	p.S679*	BRD2_uc003ocq.3_Nonsense_Mutation_p.S679*|BRD2_uc003ocp.3_Nonsense_Mutation_p.S559*|BRD2_uc010juh.2_Nonsense_Mutation_p.S714*	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	679	ET.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TTACGTGATTCAAACCCAGAA	0.498000													46	68					0	0	0.011902	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333342	33333342	+	Silent	SNP	G	A	A	rs140475230	by1000genomes	TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:33333342G>A	uc003shx.2	-	1	798	c.664C>T	c.(664-666)CTG>TTG	p.L222L		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						GGAGGCAGCAGCTTCTCAAGA	0.562000													3	32					0	0	0.009096	0	0
CUL7	9820	broad.mit.edu	37	6	43013806	43013806	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:43013806C>T	uc003otq.2	-	13	2987	c.2684G>A	c.(2683-2685)AGT>AAT	p.S895N	CUL7_uc010jyg.2_Missense_Mutation_p.S174N|CUL7_uc011dvb.1_Missense_Mutation_p.S979N|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	895	DOC.				interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CGAGTCCTCACTAGCCACAAG	0.592000													4	22					0	0	0.024334	0	0
EYS	346007	broad.mit.edu	37	6	66204905	66204905	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:66204905C>T	uc011dxu.1	-	4	937	c.399G>A	c.(397-399)ATG>ATA	p.M133I	EYS_uc003peq.2_Missense_Mutation_p.M133I|EYS_uc003per.1_Missense_Mutation_p.M133I|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	133					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TAACAGTGTGCATTCCTTTTA	0.393000													4	115					0	0	0.021553	0	0
SLC22A2	6582	broad.mit.edu	37	6	160679695	160679695	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:160679695G>T	uc003qtf.2	-	1	265	c.95C>A	c.(94-96)ACC>AAC	p.T32N	SLC22A2_uc003qte.1_Missense_Mutation_p.T32N|SLC22A2_uc003qth.1_Missense_Mutation_p.T32N	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	32	Helical; (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GGGCGCGAAGGTAGCCGAGAG	0.612000													6	94					4.68919e-08	5.52482e-08	0.008291	1	0
HECW1	23072	broad.mit.edu	37	7	43519234	43519234	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:43519234G>C	uc003tid.1	+	17	3730	c.3125G>C	c.(3124-3126)CGA>CCA	p.R1042P	HECW1_uc011kbi.1_Missense_Mutation_p.R1008P	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1042	WW 2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CACAACAGTCGAGCTACCACT	0.493000													4	302					0	0	0.014758	0	0
RELN	5649	broad.mit.edu	37	7	103138606	103138606	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:103138606G>C	uc003vca.2	-	54	8921	c.8761C>G	c.(8761-8763)CTT>GTT	p.L2921V	RELN_uc010liz.2_Missense_Mutation_p.L2921V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2921					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCTCGGCAAGAATTCCACAC	0.433000													3	185					0	0	0.004672	0	0
FAM71F1	84691	broad.mit.edu	37	7	128363345	128363345	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:128363345C>T	uc003vno.1	+	4	835	c.782C>T	c.(781-783)GCC>GTC	p.A261V	FAM71F1_uc010llo.1_Missense_Mutation_p.A162V|FAM71F1_uc011koq.1_Missense_Mutation_p.A153V|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.A162V|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.A261V	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	261										skin(1)	1						CAGATTTTTGCCGACTTACAC	0.502000													5	233					0	0	0.021553	0	0
CHRM2	1129	broad.mit.edu	37	7	136700056	136700056	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:136700056G>T	uc003vtf.1	+	4	1067	c.444G>T	c.(442-444)TGG>TGT	p.W148C	CHRM2_uc003vtg.1_Missense_Mutation_p.W148C|CHRM2_uc003vtj.1_Missense_Mutation_p.W148C|CHRM2_uc003vtk.1_Missense_Mutation_p.W148C|CHRM2_uc003vtl.1_Missense_Mutation_p.W148C|CHRM2_uc003vtm.1_Missense_Mutation_p.W148C|CHRM2_uc003vti.1_Missense_Mutation_p.W148C|CHRM2_uc003vto.1_Missense_Mutation_p.W148C|CHRM2_uc003vtn.1_Missense_Mutation_p.W148C|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	148	Helical; Name=4; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CAGCTGCCTGGGTCCTCTCTT	0.488000													8	65					7.48243e-07	8.62937e-07	0.006214	1	0
PRKAG2	51422	broad.mit.edu	37	7	151372582	151372582	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:151372582C>G	uc003wkk.2	-	4	1219	c.608G>C	c.(607-609)AGG>ACG	p.R203T	PRKAG2_uc011kvl.1_Missense_Mutation_p.R79T|PRKAG2_uc003wkj.2_Missense_Mutation_p.R159T|PRKAG2_uc010lqe.1_RNA|PRKAG2_uc003wkm.1_Missense_Mutation_p.R203T	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	203					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CGGGCAGAACCTCTGCCCTGT	0.587000													50	59					0	0	0.014410	0	0
MLL3	58508	broad.mit.edu	37	7	151879016	151879016	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:151879016G>A	uc003wla.2	-	36	6148	c.5929C>T	c.(5929-5931)CAA>TAA	p.Q1977*	MLL3_uc003wkz.2_Nonsense_Mutation_p.Q1038*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1977	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTGGGAAATTGATCTGTCATC	0.458000			N		medulloblastoma								87	563					0	0	0.014410	0	0
ERLIN2	11160	broad.mit.edu	37	8	37597912	37597912	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr8:37597912G>A	uc003xke.3	+	3	252	c.137G>A	c.(136-138)GGC>GAC	p.G46D	uc003xkb.1_5'Flank|ERLIN2_uc003xkc.3_Missense_Mutation_p.G46D|ERLIN2_uc003xkd.2_Missense_Mutation_p.G46D|ERLIN2_uc003xkf.3_Missense_Mutation_p.G46D|ERLIN2_uc003xkg.2_Missense_Mutation_p.G46D	NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	46	Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TCGACCAGCGGCCCTGGTTTC	0.537000													16	494					0	0	0.028581	0	0
ST18	9705	broad.mit.edu	37	8	53028901	53028901	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr8:53028901C>T	uc003xqz.2	-	20	3093	c.2937G>A	c.(2935-2937)CTG>CTA	p.L979L	ST18_uc011ldq.1_Silent_p.L626L|ST18_uc011ldr.1_Silent_p.L944L|ST18_uc011lds.1_Silent_p.L884L|ST18_uc003xra.2_Silent_p.L979L	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	979	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCAGCTCTTTCAGCAGACTTT	0.433000													70	60					0	0	0.014410	0	0
ST18	9705	broad.mit.edu	37	8	53028912	53028912	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr8:53028912C>T	uc003xqz.2	-	20	3082	c.2926G>A	c.(2926-2928)GAA>AAA	p.E976K	ST18_uc011ldq.1_Missense_Mutation_p.E623K|ST18_uc011ldr.1_Missense_Mutation_p.E941K|ST18_uc011lds.1_Missense_Mutation_p.E881K|ST18_uc003xra.2_Missense_Mutation_p.E976K	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	976	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AGCAGACTTTCATTGTTCTGT	0.438000													61	62					0	0	0.014410	0	0
GRHL2	79977	broad.mit.edu	37	8	102631907	102631907	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr8:102631907C>G	uc010mbu.2	+	9	1569	c.1239C>G	c.(1237-1239)ATC>ATG	p.I413M		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	413						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ATTGCCAGATCAAGGTCTTCT	0.338000													5	187					0	0	0.021553	0	0
VLDLR	7436	broad.mit.edu	37	9	2651933	2651933	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr9:2651933G>A	uc003zhk.1	+	17	2792	c.2395G>A	c.(2395-2397)GCA>ACA	p.A799T	VLDLR_uc003zhl.1_Missense_Mutation_p.A771T|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Missense_Mutation_p.A730T	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	799	Helical; (Potential).				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity	p.A799T(1)		ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		GACTTCTGCCGCATGGGCCAT	0.433000													32	73					0	0	0.015359	0	0
TYRP1	7306	broad.mit.edu	37	9	12704628	12704628	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr9:12704628C>A	uc003zkv.3	+	6	1362	c.1184C>A	c.(1183-1185)CCA>CAA	p.P395Q		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	395	Lumenal, melanosome (Potential).			PN -> SQ (in Ref. 7; CAA35820).	melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		CATTTGTCTCCAAATGATCCT	0.443000									Oculocutaneous_Albinism				34	74					3.90053e-15	4.77739e-15	0.012213	1	0
C9orf24	84688	broad.mit.edu	37	9	34397497	34397497	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr9:34397497C>T	uc003zuh.1	-	1	353	c.135G>A	c.(133-135)CCG>CCA	p.P45P		NM_032596	NP_115985	Q8NCR6	CI024_HUMAN	testes development-related NYD-SP22 isoform 1	45										ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.123)		TCCCACTTACCGGAGTCAGAA	0.522000													90	208					0	0	0.014410	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396007	38396007	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr9:38396007C>T	uc004aay.2	+	2	374	c.262C>T	c.(262-264)CGC>TGC	p.R88C		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	88					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GGAAGCCTTCCGCCTGGGGTC	0.677000													21	257					0	0	0.010504	0	0
Unknown	0	broad.mit.edu	37	MT	3413	3413	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrM:3413G>A	uc004cos.3	+	2		c.1706G>A			uc011mfh.1_5'Flank					Homo sapiens mRNA expressed only in placental villi, clone SMAP47.																		ACTACGCAAAGGCCCCAACGT	0.488000													11	7					0	0	0.016723	0	0
Unknown	0	broad.mit.edu	37	MT	12957	12957	+	RNA	SNP	T	C	C			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrM:12957T>C	uc004cox.3	+	1		c.621T>C			uc004coy.2_5'Flank					Homo sapiens NADH dehydrogenase subunit 5 (MTND5) mRNA, RNA 5, complete cds; mitochondrial gene for mitochondrial product.																		CTAAACGCTAATCCAAGCCTC	0.522000													17	9					0	0	0.012319	0	0
ZMYM3	9203	broad.mit.edu	37	X	70472882	70472882	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrX:70472882C>G	uc004dzh.1	-	2	311	c.224G>C	c.(223-225)GGA>GCA	p.G75A	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.G75A|ZMYM3_uc004dzj.1_Missense_Mutation_p.G75A|ZMYM3_uc011mpu.1_5'Flank|ZMYM3_uc004dzk.3_Missense_Mutation_p.G75A|ZMYM3_uc004dzl.3_Missense_Mutation_p.G75A|ZMYM3_uc004dzm.3_Missense_Mutation_p.G75A	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	75					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CTCAGTGGCTCCATCCAGGAC	0.652000													3	35					0	0	0.009096	0	0
STAG2	10735	broad.mit.edu	37	X	123176469	123176469	+	Nonsense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrX:123176469C>T	uc004etz.3	+	6	775	c.436C>T	c.(436-438)CGA>TGA	p.R146*	STAG2_uc004eua.2_Nonsense_Mutation_p.R146*|STAG2_uc004eub.2_Nonsense_Mutation_p.R146*|STAG2_uc004euc.2_Nonsense_Mutation_p.R146*|STAG2_uc004eud.2_Nonsense_Mutation_p.R146*|STAG2_uc004eue.2_Nonsense_Mutation_p.R146*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	146					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGAGATAATTCGAAAAATGAC	0.284000													71	4					0	0	0.014410	0	0
IL9R	3581	broad.mit.edu	37	X	155232601	155232601	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrX:155232601G>A	uc004fnv.1	+	2	238	c.59G>A	c.(58-60)CGA>CAA	p.R20Q	IL9R_uc010nvn.2_5'UTR|IL9R_uc004fnu.1_Missense_Mutation_p.R67Q	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	20					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCCCTGAGGCGAGACATGGGC	0.612000													131	136					0	0	0.014410	0	0
CCNL2	81669	broad.mit.edu	37	1	1334456	1334456	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:1334456G>A	uc001afi.2	-	1	263	c.231C>T	c.(229-231)CTC>CTT	p.L77L	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Silent_p.L77L|CCNL2_uc001afj.2_Silent_p.L77L|CCNL2_uc001afk.2_Silent_p.L77L|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	77					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CCACCACGCGGAGGTCGGTCT	0.692000													11	18					0	0	0.002450	0	0
CCNL2	81669	broad.mit.edu	37	1	1334592	1334592	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:1334592G>A	uc001afi.2	-	1	127	c.95C>T	c.(94-96)TCG>TTG	p.S32L	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Missense_Mutation_p.S32L|CCNL2_uc001afj.2_Missense_Mutation_p.S32L|CCNL2_uc001afk.2_Missense_Mutation_p.S32L|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	32					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CACCCCCTGCGACCCTGAGGG	0.607000													21	21					0	0	0.010504	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6528353	6528353	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:6528353C>T	uc001ano.1	-	21	2812	c.2711G>A	c.(2710-2712)CGA>CAA	p.R904Q	PLEKHG5_uc001ann.1_Missense_Mutation_p.R885Q|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Missense_Mutation_p.R925Q|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Missense_Mutation_p.R409Q|PLEKHG5_uc009vma.1_Missense_Mutation_p.R688Q|PLEKHG5_uc010nzr.1_Missense_Mutation_p.R917Q|PLEKHG5_uc001ank.1_Missense_Mutation_p.R848Q|PLEKHG5_uc009vmb.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anl.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anm.1_Missense_Mutation_p.R848Q|PLEKHG5_uc001anr.1_Missense_Mutation_p.R111Q	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	904					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GGAAGGAACTCGTGGGGACTC	0.662000													7	7					0	0	0.001984	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854436	12854436	+	Silent	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:12854436G>C	uc001auj.1	+	3	763	c.660G>C	c.(658-660)CTG>CTC	p.L220L		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	220											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCACGTCTGATAAGAAAGC	0.393000													336	358					0	0	0.014410	0	0
THRAP3	9967	broad.mit.edu	37	1	36748232	36748232	+	Missense_Mutation	SNP	G	A	A	rs148045717		TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:36748232G>A	uc001cae.3	+	3	292	c.68G>A	c.(67-69)CGT>CAT	p.R23H	THRAP3_uc001caf.3_Missense_Mutation_p.R23H|THRAP3_uc001cag.1_Missense_Mutation_p.R23H	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	23	Arg-rich.|Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCAAGATCTCGTTCTCGTTCA	0.453000			T	USP6	aneurysmal bone cysts								75	96					0	0	0.014410	0	0
MACF1	23499	broad.mit.edu	37	1	39910503	39910503	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:39910503G>C	uc010oiu.1	+	45	15061	c.14930G>C	c.(14929-14931)AGA>ACA	p.R4977T	MACF1_uc010ois.1_Missense_Mutation_p.R4475T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6542	Spectrin 14.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATGGAAGAAAGAAAGGTACAG	0.418000													44	54					0	0	0.009718	0	0
MACF1	23499	broad.mit.edu	37	1	39926417	39926417	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:39926417G>C	uc010oiu.1	+	57	16934	c.16803G>C	c.(16801-16803)CAG>CAC	p.Q5601H	MACF1_uc010ois.1_Missense_Mutation_p.Q5099H|MACF1_uc001cde.1_5'Flank|MACF1_uc001cdf.1_5'Flank	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7057	1 (Potential).|EF-hand 1.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATAAGGACCAGGATGGGAAGA	0.438000													5	267					0	0	0.001168	0	0
ST7L	54879	broad.mit.edu	37	1	113126670	113126670	+	Silent	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:113126670T>C	uc001ecd.2	-	7	1085	c.780A>G	c.(778-780)GCA>GCG	p.A260A	ST7L_uc009wgh.2_Intron|ST7L_uc001ecc.2_Silent_p.A77A|ST7L_uc010owg.1_Silent_p.A195A|ST7L_uc010owh.1_Intron|ST7L_uc001ece.2_Silent_p.A260A|ST7L_uc001ecf.2_Silent_p.A243A|ST7L_uc001ecg.2_RNA|ST7L_uc010owi.1_Silent_p.A195A|ST7L_uc001ech.2_Silent_p.A243A|ST7L_uc001eci.2_Silent_p.A260A|ST7L_uc009wgi.1_RNA|ST7L_uc010owj.1_Silent_p.A243A	NM_017744	NP_060214	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7-like isoform 1	260					negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGCCTTGAGTGCCTGTTTAA	0.433000													86	97					0	0	0.014410	0	0
ATP1A1	476	broad.mit.edu	37	1	116931284	116931284	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:116931284G>A	uc001ege.2	+	6	865	c.526G>A	c.(526-528)GAG>AAG	p.E176K	ATP1A1_uc010owv.1_Missense_Mutation_p.E145K|ATP1A1_uc010oww.1_Missense_Mutation_p.E176K|ATP1A1_uc010owx.1_Missense_Mutation_p.E145K	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	176	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TCGAAATGGTGAGAAAATGAG	0.398000													84	133					0	0	0.014410	0	0
LOC200030	200030	broad.mit.edu	37	1	148025786	148025786	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:148025786G>A	uc001eqf.2	-	7	1101	c.1066C>T	c.(1066-1068)CAG>TAG	p.Q356*	LOC200030_uc001eqe.2_5'UTR|LOC200030_uc001eqg.2_5'UTR|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Nonsense_Mutation_p.Q16*|NBPF14_uc001eqs.1_5'Flank	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	356	Potential.					cytoplasm					0						TGCTTGAGCTGCTCTGCAAGC	0.527000													85	294					0	0	0.014410	0	0
LOC200030	200030	broad.mit.edu	37	1	148025829	148025829	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:148025829C>T	uc001eqf.2	-	7	1058	c.1023G>A	c.(1021-1023)ATG>ATA	p.M341I	LOC200030_uc001eqe.2_5'UTR|LOC200030_uc001eqg.2_5'UTR|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Missense_Mutation_p.M1I|NBPF14_uc001eqs.1_5'Flank	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	341	Potential.					cytoplasm					0						CATTCCTCAGCATAGATTTTA	0.532000													113	387					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	1	148882025	148882025	+	RNA	SNP	C	T	T	rs150449871	by1000genomes	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:148882025C>T	uc009wkv.1	+	3		c.246C>T								Homo sapiens cDNA, FLJ17483.																		TGTTTTCTAGCAGTGACAAAT	0.343000													7	133					0	0	0.001984	0	0
TDRD10	126668	broad.mit.edu	37	1	154493835	154493835	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:154493835G>A	uc009wow.2	+	6	1087	c.249G>A	c.(247-249)GTG>GTA	p.V83V	TDRD10_uc001ffd.2_Silent_p.V83V|TDRD10_uc001ffe.2_Silent_p.V4V	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	83	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGCAGAAAGTGACACTTGCAA	0.502000													30	304					0	0	0.010818	0	0
F5	2153	broad.mit.edu	37	1	169525999	169525999	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:169525999G>C	uc001ggg.1	-	6	982	c.837C>G	c.(835-837)AAC>AAG	p.N279K	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	279	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCTTATGATGGTTCTGCTCCA	0.517000													4	111					0	0	0.009096	0	0
XPR1	9213	broad.mit.edu	37	1	180849312	180849312	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:180849312G>C	uc001goi.2	+	14	2101	c.1909G>C	c.(1909-1911)GAT>CAT	p.D637H	XPR1_uc009wxn.2_Missense_Mutation_p.D572H	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	637	EXS.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						CCTGAACGCAGATGATCAGAC	0.517000													83	83					0	0	0.014410	0	0
LRRN2	10446	broad.mit.edu	37	1	204587907	204587907	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:204587907C>T	uc001hbe.1	-	3	1602	c.1214G>A	c.(1213-1215)CGC>CAC	p.R405H	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.R405H|LRRN2_uc009xbf.1_Missense_Mutation_p.R405H|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	405	Extracellular (Potential).|LRRCT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GACCGGGAGGCGCTGGAGGTC	0.662000													4	69					0	0	0.003080	0	0
SLC26A9	115019	broad.mit.edu	37	1	205888030	205888030	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:205888030C>T	uc001hdq.2	-	19	2308	c.2194G>A	c.(2194-2196)GAC>AAC	p.D732N	SLC26A9_uc001hdm.2_5'Flank|SLC26A9_uc001hdn.2_5'Flank|SLC26A9_uc001hdo.2_Missense_Mutation_p.D400N|SLC26A9_uc001hdp.2_Missense_Mutation_p.D732N	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	732	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGGACTGCGTCATGTATGCTG	0.517000											OREG0014164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	261	295					0	0	0.014410	0	0
NEBL	10529	broad.mit.edu	37	10	21309109	21309109	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr10:21309109G>A	uc001iqk.2	-	3	540	c.186C>T	c.(184-186)TTC>TTT	p.F62F		NM_213569	NP_998734	O76041	NEBL_HUMAN	nebulette non-muscle isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CCACCGTGGTGAAGGACTGCT	0.413000													8	144					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr10:48968566A>G	uc001jgc.1	+	3		c.1234A>G								full-length cDNA clone CS0DI009YC01 of Placenta Cot 25-normalized of Homo sapiens (human).																		ACAGGATAACAAACTGGAAAA	0.284000													7	95					0	0	0.003080	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49667829	49667829	+	Missense_Mutation	SNP	C	T	T	rs75710233	byFrequency	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr10:49667829C>T	uc001jgt.2	-	5	854	c.557G>A	c.(556-558)CGC>CAC	p.R186H	ARHGAP22_uc001jgs.2_Missense_Mutation_p.R96H|ARHGAP22_uc001jgu.2_Missense_Mutation_p.R202H|ARHGAP22_uc010qgl.1_Missense_Mutation_p.R143H|ARHGAP22_uc010qgm.1_Missense_Mutation_p.R192H|ARHGAP22_uc001jgv.2_5'UTR	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	186	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						AGTGAGCCCGCGCTCCCGGAT	0.642000													48	124					0	0	0.014410	0	0
SGMS1	259230	broad.mit.edu	37	10	52071078	52071078	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr10:52071078T>C	uc001jje.2	-	9	1793	c.839A>G	c.(838-840)TAT>TGT	p.Y280C	SGMS1_uc010qhk.1_Missense_Mutation_p.Y111C|SGMS1_uc009xot.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	286	Helical; (Potential).				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						GCTGTACAGATAGTCCCCACA	0.453000													51	58					0	0	0.014410	0	0
IDE	3416	broad.mit.edu	37	10	94297234	94297234	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr10:94297234G>C	uc001kia.2	-	2	248	c.172C>G	c.(172-174)CCT>GCT	p.P58A		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	58					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTCTTCAGGAGACTTGGTA	0.388000													79	110					0	0	0.014410	0	0
WDR11	55717	broad.mit.edu	37	10	122618295	122618295	+	Silent	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr10:122618295C>A	uc010qtf.1	+	3	577	c.339C>A	c.(337-339)GCC>GCA	p.A113A	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	113	WD 2.					integral to membrane					0						AAGAGCATGCCAAGCCTATCC	0.468000													5	56					2.61681e-11	2.94166e-11	0.002450	1	0
RIC8A	60626	broad.mit.edu	37	11	209483	209483	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:209483T>A	uc001log.2	+	3	534	c.209T>A	c.(208-210)GTC>GAC	p.V70D	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Missense_Mutation_p.V70D|RIC8A_uc001loh.2_Missense_Mutation_p.V63D	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	70						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTGCAGAGTGTCCGAATCCTG	0.642000													21	66					0	0	0.008871	0	0
OR4S2	219431	broad.mit.edu	37	11	55418712	55418712	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:55418712C>T	uc001nhs.1	+	1	333	c.333C>T	c.(331-333)TTC>TTT	p.F111F		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				CTGAGATCTTCATCCTTACTG	0.403000													17	542					0	0	0.007413	0	0
APLNR	187	broad.mit.edu	37	11	57004337	57004337	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:57004337G>C	uc001njo.2	-	1	591	c.142C>G	c.(142-144)CTG>GTG	p.L48V	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	48	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						CAGAGCACCAGACCGTTGCCC	0.592000													62	72					0	0	0.014410	0	0
MS4A15	219995	broad.mit.edu	37	11	60540926	60540926	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:60540926T>A	uc009ynf.1	+	5	687	c.467T>A	c.(466-468)ATT>AAT	p.I156N	MS4A15_uc001npx.2_Missense_Mutation_p.I63N|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Missense_Mutation_p.I115N	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	156	Helical; (Potential).					integral to membrane	receptor activity			lung(1)	1						GGGACAGCCATTCTGCTCATG	0.572000													30	25					0	0	0.003755	0	0
VWCE	220001	broad.mit.edu	37	11	61026184	61026184	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:61026184G>A	uc001nra.2	-	20	3110	c.2831C>T	c.(2830-2832)CCA>CTA	p.P944L	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	944						extracellular region	calcium ion binding			ovary(1)	1						AGCCCCCACTGGGGGCTGCTG	0.662000													33	89					0	0	0.014410	0	0
STARD10	10809	broad.mit.edu	37	11	72470333	72470333	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:72470333C>G	uc001osy.2	-	3	592	c.301G>C	c.(301-303)GAG>CAG	p.E101Q	ARAP1_uc001osv.2_Intron|STARD10_uc001osz.3_Missense_Mutation_p.E101Q|STARD10_uc001ota.2_Missense_Mutation_p.E55Q|STARD10_uc001otb.2_Missense_Mutation_p.E101Q	NM_006645	NP_006636	Q9Y365	PCTL_HUMAN	START domain containing 10	101	START.										0			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			TCAAAAGTCTCAATGACGTTG	0.562000													58	58					0	0	0.014410	0	0
ARRB1	408	broad.mit.edu	37	11	74985127	74985127	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:74985127G>C	uc001owe.1	-	11	1127	c.905C>G	c.(904-906)TCT>TGT	p.S302C	ARRB1_uc001owf.1_Missense_Mutation_p.S302C	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	302					G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						CAGGGTGCTAGAGGCCAAGTT	0.602000													139	167					0	0	0.014410	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48142257	48142257	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr12:48142257G>A	uc009zkp.2	-	11	1537	c.1097C>T	c.(1096-1098)TCC>TTC	p.S366F	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Missense_Mutation_p.S366F|RAPGEF3_uc001rpz.3_Missense_Mutation_p.S408F|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Missense_Mutation_p.S420F	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	366					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		ATGAGCACTGGAATCTGGTCC	0.478000													24	43					0	0	0.005443	0	0
MLL2	8085	broad.mit.edu	37	12	49425839	49425839	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr12:49425839G>A	uc001rta.3	-	39	12649	c.12649C>T	c.(12649-12651)CAG>TAG	p.Q4217*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4217	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGCTGCTGCTGAGGACTTAAG	0.622000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			21	33					0	0	0.008361	0	0
MLL2	8085	broad.mit.edu	37	12	49426526	49426526	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr12:49426526G>A	uc001rta.3	-	39	11962	c.11962C>T	c.(11962-11964)CAG>TAG	p.Q3988*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3988	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGTTGTTGCTGAGGAGACAGT	0.378000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			13	14					0	0	0.013537	0	0
GEFT	115557	broad.mit.edu	37	12	58005752	58005752	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr12:58005752C>G	uc001spb.2	+	1	535	c.75C>G	c.(73-75)TGC>TGG	p.C25W	GEFT_uc009zpy.2_Intron|GEFT_uc001soz.1_Intron|GEFT_uc001spa.2_5'UTR|GEFT_uc001spd.2_5'Flank	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	25					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					AATGCGGCTGCTGCTTCGCCC	0.582000													3	14					0	0	0.001984	0	0
HSP90B1	7184	broad.mit.edu	37	12	104327895	104327895	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr12:104327895G>C	uc001tkb.1	+	5	678	c.573G>C	c.(571-573)TTG>TTC	p.L191F	HSP90B1_uc010swg.1_Intron|HSP90B1_uc009zui.1_Missense_Mutation_p.L191F	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	191					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CTTCTGAATTGATTGGCCAGT	0.428000													4	215					0	0	0.001168	0	0
INSM2	84684	broad.mit.edu	37	14	36005048	36005048	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:36005048C>T	uc001wth.1	+	1	1801	c.1590C>T	c.(1588-1590)TGC>TGT	p.C530C		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	530	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		GCAAGCACTGCCCGTCCACTT	0.627000													23	82					0	0	0.012319	0	0
FKBP3	2287	broad.mit.edu	37	14	45603575	45603575	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:45603575G>A	uc010tqf.1	-	1	158	c.85C>T	c.(85-87)CTG>TTG	p.L29L	FANCM_uc001wwc.2_5'Flank|FANCM_uc001wwd.3_5'Flank|FANCM_uc010anf.2_5'Flank	NM_002013	NP_002004	Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	29					protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity				0						TGTTCCTGCAGAAACTTGATA	0.652000													41	83					0	0	0.010771	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256349	69256349	+	Silent	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:69256349C>G	uc001xkh.1	-	2	1048	c.918G>C	c.(916-918)CTG>CTC	p.L306L	ZFP36L1_uc001xki.1_Silent_p.L306L	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	306					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TGGAGCTGCTCAGGTAGCCCT	0.597000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	92					0	0	0.014410	0	0
MLH3	27030	broad.mit.edu	37	14	75514890	75514890	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:75514890G>C	uc001xrd.1	-	2	1685	c.1469C>G	c.(1468-1470)TCT>TGT	p.S490C	MLH3_uc001xre.1_Missense_Mutation_p.S490C|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	490					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TTCCAGGAAAGATTTTTTATG	0.378000								MMR					118	190					0	0	0.014410	0	0
PPP2R5C	5527	broad.mit.edu	37	14	102391505	102391505	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr14:102391505C>G	uc001yko.2	+	14	1611	c.1471C>G	c.(1471-1473)CCT>GCT	p.P491A	PPP2R5C_uc010txr.1_Missense_Mutation_p.P522A|PPP2R5C_uc001ykk.2_Missense_Mutation_p.P507A|PPP2R5C_uc001ykp.2_Missense_Mutation_p.P452A	NM_002719	NP_002710	Q13362	2A5G_HUMAN	gamma isoform of regulatory subunit B56, protein	491					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity			ovary(1)|breast(1)	2						GAAGGACCGTCCTCTTGCACG	0.552000													6	374					0	0	0.001984	0	0
SNORD116-1	100033413	broad.mit.edu	37	15	25296712	25296712	+	RNA	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:25296712G>C	uc001yxg.2	+	1		c.90G>C				NR_003316				Homo sapiens small nucleolar RNA, C/D box 116-1 (SNORD116-1), non-coding RNA.												0						CATCGGAACTGAGGTCCAGCA	0.473000													81	91					0	0	0.014410	0	0
GABRB3	2562	broad.mit.edu	37	15	26793190	26793190	+	Nonsense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:26793190G>C	uc001zaz.2	-	9	1314	c.1172C>G	c.(1171-1173)TCA>TGA	p.S391*	GABRB3_uc010uae.1_Nonsense_Mutation_p.S306*|GABRB3_uc001zba.2_Nonsense_Mutation_p.S391*|GABRB3_uc001zbb.2_Nonsense_Mutation_p.S447*	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	391	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGATATTGCTGAATTCCTGGT	0.493000													104	127					0	0	0.014410	0	0
DMXL2	23312	broad.mit.edu	37	15	51857284	51857284	+	Splice_Site	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:51857284C>A	uc002abf.2	-	4	589	c.364_splice	c.e4+1	p.D122_splice	DMXL2_uc010ufy.1_Splice_Site_p.D122_splice|DMXL2_uc010bfa.2_Splice_Site_p.D122_splice	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2							cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TTGCTAAATACCTTGAGGATC	0.289000													23	27					3.5997e-14	4.07466e-14	0.014323	1	0
MCTP2	55784	broad.mit.edu	37	15	95019963	95019963	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:95019963T>C	uc002btj.2	+	21	2574	c.2509T>C	c.(2509-2511)TCC>CCC	p.S837P	MCTP2_uc010boj.2_Missense_Mutation_p.S566P|MCTP2_uc010bok.2_Missense_Mutation_p.S782P|MCTP2_uc002btl.2_Missense_Mutation_p.S425P	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	837					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAATCCCTATTCCATCGACAA	0.323000													5	170					0	0	0.001168	0	0
NTN3	4917	broad.mit.edu	37	16	2522390	2522390	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:2522390G>C	uc002cqj.2	+	1	891	c.688G>C	c.(688-690)GCA>CCA	p.A230P	TBC1D24_uc002cqk.2_5'Flank|TBC1D24_uc002cql.2_5'Flank	NM_006181	NP_006172	O00634	NET3_HUMAN	netrin 3 precursor	230	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				central_nervous_system(1)	1						GCCTAGCACGGCAGGTGACCC	0.667000													3	56					0	0	0.004672	0	0
GGA2	23062	broad.mit.edu	37	16	23503028	23503028	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:23503028G>C	uc002dlq.2	-	5	521	c.445C>G	c.(445-447)CGA>GGA	p.R149G	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	149	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		TAAGCGTCTCGAATCTTGATG	0.353000													8	333					0	0	0.004482	0	0
IL4R	3566	broad.mit.edu	37	16	27356334	27356334	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:27356334C>G	uc002don.2	+	5	596	c.354C>G	c.(352-354)AGC>AGG	p.S118R	IL4R_uc002dom.2_Missense_Mutation_p.S118R|IL4R_uc002dop.3_Missense_Mutation_p.S103R|IL4R_uc010bxy.2_Missense_Mutation_p.S118R|IL4R_uc002doo.2_5'UTR	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	118	Extracellular (Potential).			S->A: No effect on IL4 binding.	immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						TCAAGCCCAGCGAGCATGGTG	0.647000													3	128					0	0	0.004672	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29884594	29884594	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:29884594A>G	uc002duq.3	-	14	2695	c.2455T>C	c.(2455-2457)TCC>CCC	p.S819P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.S749P|SEZ6L2_uc002dur.3_Missense_Mutation_p.S749P|SEZ6L2_uc002dus.3_Missense_Mutation_p.S705P|SEZ6L2_uc010vec.1_Missense_Mutation_p.S819P|SEZ6L2_uc010ved.1_Missense_Mutation_p.S775P	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	819	Sushi 5.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GTCCACTGGGAGGGGTGGCCG	0.642000													5	46					0	0	0.013537	0	0
CX3CL1	6376	broad.mit.edu	37	16	57413597	57413597	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:57413597C>T	uc002eli.2	+	2	189	c.122C>T	c.(121-123)TCA>TTA	p.S41L		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	41	Extracellular (Potential).|Chemokine.				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						AAGATGACATCAAAGATACCT	0.517000													5	90					0	0	0.014758	0	0
WDR59	79726	broad.mit.edu	37	16	74990405	74990405	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:74990405G>A	uc002fdh.1	-	3	310	c.208C>T	c.(208-210)CAT>TAT	p.H70Y	WDR59_uc002fdi.2_Missense_Mutation_p.H70Y|WDR59_uc002fdj.2_Missense_Mutation_p.H70Y	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	70	WD 1.									ovary(1)|breast(1)	2						AAGCTGTCATGAGGATTCCAC	0.468000													40	75					0	0	0.006230	0	0
ZDHHC7	55625	broad.mit.edu	37	16	85010706	85010706	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:85010706C>T	uc002fiq.2	-	7	1098	c.745G>A	c.(745-747)GAG>AAG	p.E249K	ZDHHC7_uc010voi.1_Missense_Mutation_p.E286K|ZDHHC7_uc002fir.1_RNA	NM_017740	NP_060210	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7 isoform 2	249						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(1)	1						CTTACCGTCTCGTCGTTGCAT	0.448000													105	131					0	0	0.014410	0	0
ITGAE	3682	broad.mit.edu	37	17	3659152	3659152	+	Missense_Mutation	SNP	A	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:3659152A>T	uc002fwo.3	-	11	1310	c.1211T>A	c.(1210-1212)ATT>AAT	p.I404N		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	404	FG-GAP 3.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		ACTGAAGCCAATCTGTGCCAG	0.592000													7	7					0	0	0.003080	0	0
TP53	7157	broad.mit.edu	37	17	7579415	7579415	+	Nonsense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:7579415C>T	uc002gim.2	-	4	466	c.272G>A	c.(271-273)TGG>TAG	p.W91*	TP53_uc002gig.1_Nonsense_Mutation_p.W91*|TP53_uc002gih.2_Nonsense_Mutation_p.W91*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.W91*|TP53_uc010cni.1_Nonsense_Mutation_p.W91*|TP53_uc002gij.2_Nonsense_Mutation_p.W91*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.W52*|TP53_uc010cnk.1_Nonsense_Mutation_p.W106*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	91	Interaction with WWOX.		W -> C (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W91*(11)|p.0?(7)|p.G59fs*23(3)|p.V73fs*9(1)|p.D48fs*55(1)|p.W91fs*57(1)|p.A88fs*52(1)|p.W91fs*13(1)|p.P87fs*54(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGACAGGGGCCAGGAGGGGGC	0.632000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	97					0	0	0.012319	0	0
KRT13	3860	broad.mit.edu	37	17	39659037	39659037	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:39659037T>A	uc002hwu.1	-	5	988	c.925A>T	c.(925-927)ACC>TCC	p.T309S	KRT13_uc002hwv.1_Missense_Mutation_p.T309S|KRT13_uc002hww.2_Missense_Mutation_p.T202S|KRT13_uc010wfr.1_Missense_Mutation_p.T202S|KRT13_uc010cxo.2_Missense_Mutation_p.T309S|KRT13_uc002hwx.1_Missense_Mutation_p.T297S	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	309	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GCAGTGTTGGTAGACACCTCC	0.577000													161	198					0	0	0.014410	0	0
DBF4B	80174	broad.mit.edu	37	17	42828063	42828063	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:42828063C>T	uc002ihf.2	+	14	1503	c.1290C>T	c.(1288-1290)CTC>CTT	p.L430L	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	430					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				CCACAACCCTCCTGCCGGCCT	0.617000													57	59					0	0	0.014410	0	0
EPN3	55040	broad.mit.edu	37	17	48615544	48615544	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:48615544G>A	uc002ira.3	+	3	1102	c.667G>A	c.(667-669)GAG>AAG	p.E223K	EPN3_uc010wms.1_Missense_Mutation_p.E278K|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.E223K	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	223	UIM 1.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CATGAGCCGTGAGGAGGCAGA	0.667000													21	11					0	0	0.003330	0	0
EPN3	55040	broad.mit.edu	37	17	48616322	48616322	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:48616322G>C	uc002ira.3	+	4	1194	c.759G>C	c.(757-759)GAG>GAC	p.E253D	EPN3_uc010wms.1_Intron|EPN3_uc010wmt.1_Intron|EPN3_uc010wmu.1_Intron	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	253	UIM 2.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AGGAGCACGAGAAGGTAGTGG	0.687000													7	9					0	0	0.008291	0	0
SPATA20	64847	broad.mit.edu	37	17	48628090	48628090	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:48628090G>A	uc002irf.2	+	10	1288	c.1147G>A	c.(1147-1149)GAA>AAA	p.E383K	SPATA20_uc002irc.2_Missense_Mutation_p.E50K|SPATA20_uc002ire.2_Missense_Mutation_p.E339K|SPATA20_uc002ird.2_Missense_Mutation_p.E399K|SPATA20_uc010wmv.1_3'UTR|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	383					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CTATAGCGCAGAAGATGCAGA	0.672000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	154	190					0	0	0.014410	0	0
SPATA20	64847	broad.mit.edu	37	17	48628385	48628385	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:48628385G>A	uc002irf.2	+	11	1503	c.1362G>A	c.(1360-1362)CAG>CAA	p.Q454Q	SPATA20_uc002irc.2_Silent_p.Q121Q|SPATA20_uc002ire.2_Silent_p.Q410Q|SPATA20_uc002ird.2_Silent_p.Q470Q|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	454					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			TGCAGGGCCAGAATGTGCTGA	0.637000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	62					0	0	0.014410	0	0
DHX40P1	653645	broad.mit.edu	37	17	58066651	58066651	+	Silent	SNP	C	T	T	rs144367363	by1000genomes	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:58066651C>T	uc002iyf.2	-	9	721	c.486G>A	c.(484-486)CAG>CAA	p.Q162Q	uc002iye.1_Intron	NR_002924				Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 40 pseudogene, mRNA (cDNA clone IMAGE:5170263).												0						ACTGGTAAAGCTGTTTAAGAG	0.333000													4	46					0	0	0.009096	0	0
TEX2	55852	broad.mit.edu	37	17	62238165	62238165	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:62238165C>G	uc002jec.2	-	8	2973	c.2800G>C	c.(2800-2802)GAA>CAA	p.E934Q	TEX2_uc002jed.2_Missense_Mutation_p.E941Q|TEX2_uc002jee.2_Missense_Mutation_p.E934Q	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	934					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CCTTACCCTTCTTTGCCAATT	0.463000													610	266					0	0	0.014410	0	0
CACNG4	27092	broad.mit.edu	37	17	65026963	65026963	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:65026963T>C	uc002jft.1	+	4	842	c.827T>C	c.(826-828)ATG>ACG	p.M276T		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	276	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			GAGCTGTCCATGTACACGCTG	0.647000													26	112					0	0	0.007291	0	0
SLC38A10	124565	broad.mit.edu	37	17	79249777	79249777	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr17:79249777C>T	uc002jzz.1	-	8	1279	c.904G>A	c.(904-906)GAG>AAG	p.E302K	SLC38A10_uc002jzy.1_Missense_Mutation_p.E220K|SLC38A10_uc002kab.2_Missense_Mutation_p.E302K	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	302					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ACCTGCTGCTCACACAGCAGC	0.597000													60	218					0	0	0.014410	0	0
DSC2	1824	broad.mit.edu	37	18	28660162	28660162	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr18:28660162G>C	uc002kwl.3	-	10	1874	c.1420C>G	c.(1420-1422)CCA>GCA	p.P474A	DSC2_uc002kwk.3_Missense_Mutation_p.P474A	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	474	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GTCTGTATTGGAGGGTTACAC	0.443000													201	174					0	0	0.014410	0	0
C19orf21	126353	broad.mit.edu	37	19	757669	757669	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:757669C>T	uc002lpo.2	+	2	806	c.723C>T	c.(721-723)AAC>AAT	p.N241N		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	241										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTGGCCAACGGGCACGTGG	0.672000													25	24					0	0	0.005443	0	0
PIK3R2	5296	broad.mit.edu	37	19	18279617	18279617	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:18279617G>A	uc002nia.1	+	15	2402	c.1890G>A	c.(1888-1890)ACG>ACA	p.T630T	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	630	SH2 2.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						TCAACCGCACGCAGGCAGAGG	0.657000											OREG0025359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	23					0	0	0.006122	0	0
CYP2S1	29785	broad.mit.edu	37	19	41709523	41709523	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:41709523G>A	uc002opw.2	+	7	1200	c.1145G>A	c.(1144-1146)CGA>CAA	p.R382Q	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Missense_Mutation_p.R107Q	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	382					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						ACCCGCTTCCGAGGGTACACC	0.667000													3	4					0	0	0.009096	0	0
PRR12	57479	broad.mit.edu	37	19	50099849	50099849	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:50099849G>A	uc002poo.3	+	4	2257	c.2257G>A	c.(2257-2259)GCC>ACC	p.A753T		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CGGGGCAGGCGCCAAGGAGCT	0.692000													6	11					0	0	0.001168	0	0
NLRP9	338321	broad.mit.edu	37	19	56244727	56244727	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr19:56244727C>A	uc002qly.2	-	2	498	c.470G>T	c.(469-471)GGA>GTA	p.G157V		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	157	NACHT.|ATP (Potential).					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GGTTGTTTTTCCAATTCCATC	0.408000													4	136					0.00909568	0.00962725	0.009096	1	0
ADCY3	109	broad.mit.edu	37	2	25057766	25057766	+	Missense_Mutation	SNP	G	A	A	rs142082596	by1000genomes	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:25057766G>A	uc002rfs.3	-	9	1901	c.1702C>T	c.(1702-1704)CGC>TGC	p.R568C	ADCY3_uc002rfr.3_Missense_Mutation_p.R201C|ADCY3_uc010ykm.1_Missense_Mutation_p.R568C	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	568	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TCCTGCAGGCGCAGCCTCCGG	0.652000													3	40					0	0	0.004672	0	0
ETAA1	54465	broad.mit.edu	37	2	67631299	67631299	+	Silent	SNP	A	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:67631299A>G	uc002sdz.1	+	5	1624	c.1485A>G	c.(1483-1485)CAA>CAG	p.Q495Q		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	495						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						ACGAAATTCAAAATTGTATAG	0.279000													42	40					0	0	0.006999	0	0
AFF3	3899	broad.mit.edu	37	2	100623250	100623250	+	Silent	SNP	G	A	A	rs138844530	by1000genomes	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:100623250G>A	uc002tag.2	-	6	953	c.717C>T	c.(715-717)GAC>GAT	p.D239D	AFF3_uc002taf.2_Silent_p.D264D|AFF3_uc010fiq.1_Silent_p.D239D|AFF3_uc010yvr.1_Silent_p.D393D|AFF3_uc002tah.1_Silent_p.D264D|AFF3_uc010fir.1_Silent_p.D316D|AFF3_uc002tai.2_Silent_p.D161D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	239					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GATCTTGGCCGTCCATTGGCC	0.572000													37	50					0	0	0.004878	0	0
SH3RF3	344558	broad.mit.edu	37	2	110065844	110065844	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:110065844G>A	uc010ywt.1	+	8	2047	c.2047G>A	c.(2047-2049)GCA>ACA	p.A683T		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	683							zinc ion binding			ovary(1)	1						CGTCAGTGCCGCAAACCTCAA	0.622000													3	35					0	0	0.004672	0	0
NEB	4703	broad.mit.edu	37	2	152397247	152397247	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:152397247C>T	uc010fnx.2	-	109	15839	c.15648G>A	c.(15646-15648)TTG>TTA	p.L5216L	NEB_uc002txr.2_Silent_p.L1639L	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5216	Nebulin 142.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TAGCATGCTTCAAGGCTGTGG	0.433000													8	146					0	0	0.006214	0	0
CCDC108	255101	broad.mit.edu	37	2	219886640	219886640	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:219886640C>T	uc002vjl.1	-	18	3076	c.2992G>A	c.(2992-2994)GAG>AAG	p.E998K	CCDC108_uc002vjm.3_5'Flank	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	998						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGGCCAGCTCCTTTTCCTTT	0.597000													80	57					0	0	0.014410	0	0
TUBA4A	7277	broad.mit.edu	37	2	220115274	220115274	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:220115274C>T	uc002vkt.1	-	4	1205	c.1147G>A	c.(1147-1149)GCC>ACC	p.A383T	TUBA4A_uc010zkz.1_Missense_Mutation_p.A368T|TUBA4B_uc002vku.2_5'Flank|TUBA4B_uc002vkv.1_5'Flank	NM_006000	NP_005991	P68366	TBA4A_HUMAN	tubulin, alpha 4a	383					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)	3		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCGGCGATGGCGGTCGTGTTG	0.622000													4	71					0	0	0.009096	0	0
OBSL1	23363	broad.mit.edu	37	2	220420911	220420911	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr2:220420911G>A	uc010fwk.2	-	14	4497	c.4440C>T	c.(4438-4440)GCC>GCT	p.A1480A	OBSL1_uc002vmh.1_Silent_p.A379A|OBSL1_uc010zli.1_Silent_p.A287A|OBSL1_uc010fwl.1_Silent_p.A955A	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1480	Ig-like 12.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CCCAGCGCACGGCCCCCGCTG	0.657000													5	9					0	0	0.001984	0	0
CPXM1	56265	broad.mit.edu	37	20	2775058	2775058	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr20:2775058C>A	uc002wgu.2	-	14	2047	c.1983G>T	c.(1981-1983)TGG>TGT	p.W661C	CPXM1_uc010gas.2_Missense_Mutation_p.W587C	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	661					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						TCAGCAGACGCCAATAATCCC	0.597000													19	61					1.64113e-05	1.77156e-05	0.010504	1	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	A	A	rs7266938	by1000genomes	TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr20:29625877G>A	uc010ztl.1	+	2	63	c.31G>A	c.(31-33)GCC>ACC	p.A11T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GTACAGAATCGCCCTGAAATC	0.353000													13	212					0	0	0.012319	0	0
CTCFL	140690	broad.mit.edu	37	20	56090811	56090811	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr20:56090811C>G	uc010gix.1	-	5	1801	c.1139G>C	c.(1138-1140)AGA>ACA	p.R380T	CTCFL_uc010giw.1_Missense_Mutation_p.R380T|CTCFL_uc002xym.2_Missense_Mutation_p.R380T|CTCFL_uc010giz.1_5'UTR|CTCFL_uc010giy.1_5'UTR|CTCFL_uc010gja.1_Missense_Mutation_p.R380T|CTCFL_uc010gjb.1_Missense_Mutation_p.R380T|CTCFL_uc010gjc.1_Missense_Mutation_p.R380T|CTCFL_uc010gjd.1_Missense_Mutation_p.R380T|CTCFL_uc010gje.2_Missense_Mutation_p.R380T|CTCFL_uc010gjf.2_Missense_Mutation_p.R175T|CTCFL_uc010gjg.2_Missense_Mutation_p.R112T|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Missense_Mutation_p.R175T|CTCFL_uc010gjj.1_Missense_Mutation_p.R380T	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	380	C2H2-type 5.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GTAGGTATCTCTGCTGGCATA	0.483000													219	278					0	0	0.014410	0	0
ZBTB46	140685	broad.mit.edu	37	20	62407208	62407208	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr20:62407208G>A	uc002ygv.1	-	3	1246	c.1045C>T	c.(1045-1047)CTG>TTG	p.L349L	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GGAGGGCCCAGATAGCTGGCT	0.662000													85	97					0	0	0.014410	0	0
C21orf99	149992	broad.mit.edu	37	21	14439254	14439254	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr21:14439254G>A	uc002yja.3	+	10		c.2772G>A				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AGGAAAAATCGAAGAGCAACA	0.303000													12	24					0	0	0.001855	0	0
SLC25A1	6576	broad.mit.edu	37	22	19164390	19164390	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:19164390G>A	uc002zoz.2	-	6	715	c.600C>T	c.(598-600)TTC>TTT	p.F200F	SLC25A1_uc002zoy.2_Silent_p.F97F|SLC25A1_uc002zpa.2_Silent_p.F148F	NM_005984	NP_005975	P53007	TXTP_HUMAN	solute carrier family 25 (mitochondrial carrier;	200	Helical; Name=4; (Potential).|Solcar 2.				gluconeogenesis|long-chain fatty-acyl-CoA biosynthetic process|mitochondrial citrate transport|triglyceride biosynthetic process	integral to membrane|mitochondrial inner membrane	citrate transmembrane transporter activity|protein binding				0	Colorectal(54;0.0993)	all_lung(157;9.94e-09)		Lung(27;0.124)		AGGTCATGACGAAGAAGCGGA	0.642000													4	125					0	0	0.001168	0	0
PICK1	9463	broad.mit.edu	37	22	38470965	38470965	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:38470965C>G	uc003auq.2	+	13	1464	c.1074C>G	c.(1072-1074)TTC>TTG	p.F358L	PICK1_uc003aur.2_Missense_Mutation_p.F358L|PICK1_uc003aus.2_Missense_Mutation_p.F358L|PICK1_uc003aut.2_Missense_Mutation_p.F358L	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	358					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					CCGACGTCTTCCCCATCGAGG	0.532000													19	37					0	0	0.007413	0	0
MKL1	57591	broad.mit.edu	37	22	40814967	40814967	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:40814967G>A	uc003ayv.1	-	9	1682	c.1475C>T	c.(1474-1476)TCG>TTG	p.S492L	MKL1_uc003ayw.1_Missense_Mutation_p.S492L|MKL1_uc010gye.1_Missense_Mutation_p.S492L|MKL1_uc010gyf.1_Missense_Mutation_p.S442L	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	492					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity	p.S492S(1)		ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTGCAGTGGCGAGGCCTGCAG	0.677000			T	RBM15	acute megakaryocytic leukemia								10	44					0	0	0.008291	0	0
PARVB	29780	broad.mit.edu	37	22	44564537	44564537	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:44564537C>T	uc003ben.2	+	13	1126	c.1074C>T	c.(1072-1074)ACC>ACT	p.T358T	PARVB_uc003bem.2_Silent_p.T391T|PARVB_uc010gzn.2_Silent_p.T283T|PARVB_uc003beo.2_Silent_p.T321T	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	358	CH 2.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				ACCTGTTCACCAAGTACAAGA	0.552000													11	86					0	0	0.010729	0	0
GTSE1	51512	broad.mit.edu	37	22	46712115	46712115	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:46712115C>T	uc011aqy.1	+	7	1450	c.1238C>T	c.(1237-1239)CCC>CTC	p.P413L	GTSE1_uc011aqz.1_Missense_Mutation_p.P260L|GTSE1_uc003bhl.1_Missense_Mutation_p.P38L|GTSE1_uc003bhm.1_Missense_Mutation_p.P38L	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	394					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CTCACGGCACCCCCCTCAGCA	0.627000													4	117					0	0	0.014758	0	0
CELSR1	9620	broad.mit.edu	37	22	46930992	46930992	+	Silent	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr22:46930992G>A	uc003bhw.1	-	1	2076	c.2076C>T	c.(2074-2076)TAC>TAT	p.Y692Y		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	692	Extracellular (Potential).|Cadherin 5.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GACGAAGCTCGTAGGTGGGCT	0.642000													9	28					0	0	0.013537	0	0
LHFPL4	375323	broad.mit.edu	37	3	9547649	9547649	+	Splice_Site	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:9547649G>A	uc003bry.2	-	3	929	c.643_splice	c.e3+1	p.D215_splice		NM_198560	NP_940962	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4							integral to membrane				ovary(2)|skin(1)	3	Medulloblastoma(99;0.227)					CAGCACACTCGCCTTTGTTCT	0.592000													129	140					0	0	0.014410	0	0
SLC6A11	6538	broad.mit.edu	37	3	10885923	10885923	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:10885923C>T	uc003bvz.2	+	5	682	c.648C>T	c.(646-648)GAC>GAT	p.D216D		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	216	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CCATCTCTGACGGGATCGAGC	0.587000													3	81					0	0	0.004672	0	0
EFHB	151651	broad.mit.edu	37	3	19925989	19925989	+	Silent	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:19925989G>C	uc003cbl.3	-	11	2248	c.2052C>G	c.(2050-2052)CTC>CTG	p.L684L	EFHB_uc003cbm.2_Silent_p.L554L	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	684					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						GAAGTGTCCGGAGAGTCTTTT	0.393000													78	94					0	0	0.014410	0	0
RAD54L2	23132	broad.mit.edu	37	3	51667682	51667682	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:51667682C>T	uc011bdt.1	+	7	1040	c.915C>T	c.(913-915)CAC>CAT	p.H305H	RAD54L2_uc003dbh.2_5'UTR|RAD54L2_uc011bdu.1_5'UTR|RAD54L2_uc003dbj.2_5'UTR	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	305	Helicase ATP-binding.|ATP (By similarity).					nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TTCTGGCCCACAGCATGGGTC	0.527000													6	197					0	0	0.001168	0	0
PARP3	10039	broad.mit.edu	37	3	51979556	51979556	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:51979556G>C	uc003dby.2	+	7	1278	c.907G>C	c.(907-909)GAG>CAG	p.E303Q	PARP3_uc003dbz.2_Missense_Mutation_p.E310Q	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	303					DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GGCAGTCTCTGAGCAGGAGAA	0.622000													3	99					0	0	0.004672	0	0
FLNB	2317	broad.mit.edu	37	3	58089735	58089735	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:58089735C>T	uc003djj.2	+	10	1698	c.1533C>T	c.(1531-1533)TAC>TAT	p.Y511Y	FLNB_uc010hne.2_Silent_p.Y511Y|FLNB_uc003djk.2_Silent_p.Y511Y|FLNB_uc010hnf.2_Silent_p.Y511Y|FLNB_uc003djl.2_Silent_p.Y342Y|FLNB_uc003djm.2_Silent_p.Y342Y	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	511	Filamin 3.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ATGGGGTCTACGCATTCGAGT	0.542000													4	158					0	0	0.009096	0	0
GOLGB1	2804	broad.mit.edu	37	3	121386444	121386444	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:121386444G>A	uc003eei.3	-	20	9544	c.9418C>T	c.(9418-9420)CAG>TAG	p.Q3140*	GOLGB1_uc010hrc.2_Nonsense_Mutation_p.Q3150*|GOLGB1_uc003eej.3_Nonsense_Mutation_p.Q3106*	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	3140	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AGCTGCTGCTGAGCTTCAGAA	0.423000													4	121					0	0	0.014758	0	0
COL6A6	131873	broad.mit.edu	37	3	130287049	130287049	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:130287049G>A	uc010htl.2	+	5	2033	c.2002G>A	c.(2002-2004)GAC>AAC	p.D668N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	668	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CCAGTTCAGCGACATCAATAA	0.423000													128	151					0	0	0.014410	0	0
DLG1	1739	broad.mit.edu	37	3	196771534	196771534	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr3:196771534G>C	uc003fxo.3	-	26	2865	c.2675C>G	c.(2674-2676)TCT>TGT	p.S892C	DLG1_uc011bub.1_Missense_Mutation_p.S788C|DLG1_uc011buc.1_Missense_Mutation_p.S776C|DLG1_uc011bud.1_Missense_Mutation_p.S575C|DLG1_uc003fxn.3_Missense_Mutation_p.S914C|DLG1_uc011bue.1_Missense_Mutation_p.S880C|DLG1_uc010ial.2_Missense_Mutation_p.S892C	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	892					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GTAAGAACCAGATTGTTCTTC	0.378000													6	210					0	0	0.001984	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	G	G	rs121913483		TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562000		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				8	9					0	0	0.010729	0	0
UNC5C	8633	broad.mit.edu	37	4	96127913	96127913	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:96127913G>T	uc003htp.1	-	11	1922	c.1768C>A	c.(1768-1770)CCT>ACT	p.P590T	UNC5C_uc010ilc.1_Missense_Mutation_p.P609T	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	590	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CTCACCACAGGGGTCAAAAGT	0.537000													16	80					3.41278e-10	3.81016e-10	0.004990	1	0
EXOSC9	5393	broad.mit.edu	37	4	122722582	122722582	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:122722582G>A	uc003iea.2	+	1	111	c.3G>A	c.(1-3)ATG>ATA	p.M1I	EXOSC9_uc003idz.2_Missense_Mutation_p.M1I|EXOSC9_uc003ieb.2_5'Flank	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	1	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						CCAACACCATGAAGGAAACGC	0.607000													58	87					0	0	0.014410	0	0
TRIML1	339976	broad.mit.edu	37	4	189068521	189068521	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr4:189068521G>A	uc003izm.1	+	6	1517	c.1402G>A	c.(1402-1404)GTC>ATC	p.V468I	TRIML1_uc003izn.1_Missense_Mutation_p.V192I	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	468	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GAACAGCCACGTCTGAGGGGC	0.542000													29	38					0	0	0.014410	0	0
WDR41	55255	broad.mit.edu	37	5	76749713	76749713	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:76749713C>A	uc003kff.1	-	6	739	c.452G>T	c.(451-453)GGT>GTT	p.G151V	WDR41_uc011csy.1_Missense_Mutation_p.G151V|WDR41_uc011csz.1_Missense_Mutation_p.G96V|WDR41_uc011cta.1_RNA|WDR41_uc011ctb.1_Intron	NM_018268	NP_060738	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	151	WD 3.										0		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		GTCATTCCCACCAGAAAGCCA	0.353000													7	146					1.06961e-07	1.17011e-07	0.003080	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140725009	140725009	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:140725009C>T	uc003ljm.1	+	1	1409	c.1409C>T	c.(1408-1410)TCC>TTC	p.S470F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.S230F|PCDHGA3_uc011dap.1_Missense_Mutation_p.S470F	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	470	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGAGCCTCCATCTTCTCA	0.547000													127	146					0	0	0.014410	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811015	140811015	+	Missense_Mutation	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:140811015T>C	uc003lkt.1	+	1	858	c.689T>C	c.(688-690)GTG>GCG	p.V230A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.V230A	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	230	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCATCCGCGTGATGGTTCTG	0.657000													60	79					0	0	0.014410	0	0
CLINT1	9685	broad.mit.edu	37	5	157240138	157240138	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:157240138C>G	uc003lxj.1	-	5	640	c.450G>C	c.(448-450)AAG>AAC	p.K150N	CLINT1_uc003lxi.1_Missense_Mutation_p.K132N|CLINT1_uc011ddv.1_Missense_Mutation_p.K150N	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	150					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTTTGCTTTCTTTCGCTCTT	0.423000													70	73					0	0	0.014410	0	0
FLT4	2324	broad.mit.edu	37	5	180048230	180048230	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr5:180048230C>T	uc003mma.3	-	14	2122	c.2043G>A	c.(2041-2043)ACG>ACA	p.T681T	FLT4_uc003mlz.3_Silent_p.T681T|FLT4_uc003mmb.1_Silent_p.T214T|FLT4_uc011dgy.1_Silent_p.T681T	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	681	Ig-like C2-type 7.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCAAGTTCTGCGTGAGCCGAG	0.637000									Congenital_Hereditary_Lymphedema				26	27					0	0	0.006320	0	0
OR14J1	442191	broad.mit.edu	37	6	29274483	29274483	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:29274483C>T	uc011dln.1	+	1	17	c.17C>T	c.(16-18)TCA>TTA	p.S6L		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AATTTGACTTCAATGAGTGGA	0.403000													138	218					0	0	0.014410	0	0
BRD2	6046	broad.mit.edu	37	6	32945959	32945959	+	Silent	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:32945959C>G	uc003ocn.3	+	10	3336	c.1635C>G	c.(1633-1635)CCC>CCG	p.P545P	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.P545P|BRD2_uc003ocp.3_Silent_p.P425P|BRD2_uc010juh.2_Silent_p.P545P	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	545	Arg/Lys-rich (highly basic).				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TATCCAAGCCCAAGAGGAAAA	0.463000													33	48					0	0	0.012213	0	0
BRD2	6046	broad.mit.edu	37	6	32947799	32947799	+	Nonsense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:32947799C>G	uc003ocn.3	+	11	3737	c.2036C>G	c.(2035-2037)TCA>TGA	p.S679*	BRD2_uc003ocq.3_Nonsense_Mutation_p.S679*|BRD2_uc003ocp.3_Nonsense_Mutation_p.S559*|BRD2_uc010juh.2_Nonsense_Mutation_p.S714*	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	679	ET.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TTACGTGATTCAAACCCAGAA	0.498000													42	50					0	0	0.007835	0	0
RIMS1	22999	broad.mit.edu	37	6	72892038	72892038	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:72892038C>T	uc003pga.2	+	6	941	c.864C>T	c.(862-864)AGC>AGT	p.S288S	RIMS1_uc011dyb.1_5'UTR|RIMS1_uc003pgc.2_5'UTR|RIMS1_uc003pgb.3_5'UTR	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	288					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CCCTGAAGAGCGAGCGGAAAC	0.542000													3	95					0	0	0.004672	0	0
WTAP	9589	broad.mit.edu	37	6	160157288	160157288	+	Splice_Site	SNP	A	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:160157288A>T	uc003qsl.2	+	2	215	c.-7_splice	c.e2-2		WTAP_uc010kjx.2_Splice_Site|WTAP_uc003qsk.2_Splice_Site|WTAP_uc003qsm.1_Splice_Site|WTAP_uc003qsn.2_Splice_Site	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1						cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		TTTTTTTTTTAGGATTCAAGA	0.318000													5	274					0	0	0.014758	0	0
MACC1	346389	broad.mit.edu	37	7	20199090	20199090	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:20199090C>A	uc003sus.3	-	5	1203	c.894G>T	c.(892-894)AAG>AAT	p.K298N	MACC1_uc010kug.2_Missense_Mutation_p.K298N	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	298					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TGAAAGGATCCTTTCTTACTT	0.413000													21	92					2.4624e-09	2.71196e-09	0.008871	1	0
HECW1	23072	broad.mit.edu	37	7	43519234	43519234	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:43519234G>C	uc003tid.1	+	17	3730	c.3125G>C	c.(3124-3126)CGA>CCA	p.R1042P	HECW1_uc011kbi.1_Missense_Mutation_p.R1008P	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1042	WW 2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CACAACAGTCGAGCTACCACT	0.493000													7	246					0	0	0.003080	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117407188	117407188	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:117407188C>G	uc003vjf.2	-	9	2913	c.2821G>C	c.(2821-2823)GAA>CAA	p.E941Q		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	941	ANK 6.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TCTCTCCTTTCTGGCTCAAGC	0.433000													4	180					0	0	0.014758	0	0
CHRM2	1129	broad.mit.edu	37	7	136700056	136700056	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:136700056G>T	uc003vtf.1	+	4	1067	c.444G>T	c.(442-444)TGG>TGT	p.W148C	CHRM2_uc003vtg.1_Missense_Mutation_p.W148C|CHRM2_uc003vtj.1_Missense_Mutation_p.W148C|CHRM2_uc003vtk.1_Missense_Mutation_p.W148C|CHRM2_uc003vtl.1_Missense_Mutation_p.W148C|CHRM2_uc003vtm.1_Missense_Mutation_p.W148C|CHRM2_uc003vti.1_Missense_Mutation_p.W148C|CHRM2_uc003vto.1_Missense_Mutation_p.W148C|CHRM2_uc003vtn.1_Missense_Mutation_p.W148C|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	148	Helical; Name=4; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CAGCTGCCTGGGTCCTCTCTT	0.488000													21	99					2.98393e-07	3.24254e-07	0.016522	1	0
PRKAG2	51422	broad.mit.edu	37	7	151372582	151372582	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:151372582C>G	uc003wkk.2	-	4	1219	c.608G>C	c.(607-609)AGG>ACG	p.R203T	PRKAG2_uc011kvl.1_Missense_Mutation_p.R79T|PRKAG2_uc003wkj.2_Missense_Mutation_p.R159T|PRKAG2_uc010lqe.1_RNA|PRKAG2_uc003wkm.1_Missense_Mutation_p.R203T	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	203					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CGGGCAGAACCTCTGCCCTGT	0.587000													45	59					0	0	0.013114	0	0
MLL3	58508	broad.mit.edu	37	7	151879016	151879016	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr7:151879016G>A	uc003wla.2	-	36	6148	c.5929C>T	c.(5929-5931)CAA>TAA	p.Q1977*	MLL3_uc003wkz.2_Nonsense_Mutation_p.Q1038*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1977	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTGGGAAATTGATCTGTCATC	0.458000			N		medulloblastoma								93	509					0	0	0.014410	0	0
ERLIN2	11160	broad.mit.edu	37	8	37597912	37597912	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr8:37597912G>A	uc003xke.3	+	3	252	c.137G>A	c.(136-138)GGC>GAC	p.G46D	uc003xkb.1_5'Flank|ERLIN2_uc003xkc.3_Missense_Mutation_p.G46D|ERLIN2_uc003xkd.2_Missense_Mutation_p.G46D|ERLIN2_uc003xkf.3_Missense_Mutation_p.G46D|ERLIN2_uc003xkg.2_Missense_Mutation_p.G46D	NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	46	Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TCGACCAGCGGCCCTGGTTTC	0.537000													20	417					0	0	0.014323	0	0
ST18	9705	broad.mit.edu	37	8	53028901	53028901	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr8:53028901C>T	uc003xqz.2	-	20	3093	c.2937G>A	c.(2935-2937)CTG>CTA	p.L979L	ST18_uc011ldq.1_Silent_p.L626L|ST18_uc011ldr.1_Silent_p.L944L|ST18_uc011lds.1_Silent_p.L884L|ST18_uc003xra.2_Silent_p.L979L	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	979	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCAGCTCTTTCAGCAGACTTT	0.433000													64	97					0	0	0.014410	0	0
ST18	9705	broad.mit.edu	37	8	53028912	53028912	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr8:53028912C>T	uc003xqz.2	-	20	3082	c.2926G>A	c.(2926-2928)GAA>AAA	p.E976K	ST18_uc011ldq.1_Missense_Mutation_p.E623K|ST18_uc011ldr.1_Missense_Mutation_p.E941K|ST18_uc011lds.1_Missense_Mutation_p.E881K|ST18_uc003xra.2_Missense_Mutation_p.E976K	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	976	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AGCAGACTTTCATTGTTCTGT	0.438000													54	93					0	0	0.014410	0	0
GRHL2	79977	broad.mit.edu	37	8	102631907	102631907	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr8:102631907C>G	uc010mbu.2	+	9	1569	c.1239C>G	c.(1237-1239)ATC>ATG	p.I413M		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	413						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ATTGCCAGATCAAGGTCTTCT	0.338000													6	224					0	0	0.003080	0	0
VLDLR	7436	broad.mit.edu	37	9	2651933	2651933	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr9:2651933G>A	uc003zhk.1	+	17	2792	c.2395G>A	c.(2395-2397)GCA>ACA	p.A799T	VLDLR_uc003zhl.1_Missense_Mutation_p.A771T|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Missense_Mutation_p.A730T	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	799	Helical; (Potential).				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity	p.A799T(1)		ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		GACTTCTGCCGCATGGGCCAT	0.433000													43	108					0	0	0.013114	0	0
TYRP1	7306	broad.mit.edu	37	9	12704628	12704628	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr9:12704628C>A	uc003zkv.3	+	6	1362	c.1184C>A	c.(1183-1185)CCA>CAA	p.P395Q		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	395	Lumenal, melanosome (Potential).			PN -> SQ (in Ref. 7; CAA35820).	melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		CATTTGTCTCCAAATGATCCT	0.443000									Oculocutaneous_Albinism				98	238					1.14069e-49	1.30938e-49	0.014410	1	0
C9orf24	84688	broad.mit.edu	37	9	34397497	34397497	+	Silent	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr9:34397497C>T	uc003zuh.1	-	1	353	c.135G>A	c.(133-135)CCG>CCA	p.P45P		NM_032596	NP_115985	Q8NCR6	CI024_HUMAN	testes development-related NYD-SP22 isoform 1	45										ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.123)		TCCCACTTACCGGAGTCAGAA	0.522000													79	187					0	0	0.014410	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396007	38396007	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr9:38396007C>T	uc004aay.2	+	2	374	c.262C>T	c.(262-264)CGC>TGC	p.R88C		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	88					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GGAAGCCTTCCGCCTGGGGTC	0.677000													19	234					0	0	0.010504	0	0
Unknown	0	broad.mit.edu	37	MT	3413	3413	+	RNA	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrM:3413G>A	uc004cos.3	+	2		c.1706G>A			uc011mfh.1_5'Flank					Homo sapiens mRNA expressed only in placental villi, clone SMAP47.																		ACTACGCAAAGGCCCCAACGT	0.488000													14	11					0	0	0.003163	0	0
Unknown	0	broad.mit.edu	37	MT	12957	12957	+	RNA	SNP	T	C	C			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrM:12957T>C	uc004cox.3	+	1		c.621T>C			uc004coy.2_5'Flank					Homo sapiens NADH dehydrogenase subunit 5 (MTND5) mRNA, RNA 5, complete cds; mitochondrial gene for mitochondrial product.																		CTAAACGCTAATCCAAGCCTC	0.522000													30	12					0	0	0.010818	0	0
ATRX	546	broad.mit.edu	37	X	76939481	76939481	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrX:76939481C>G	uc004ecp.3	-	9	1499	c.1267G>C	c.(1267-1269)GTA>CTA	p.V423L	ATRX_uc004ecq.3_Missense_Mutation_p.V385L|ATRX_uc004eco.3_Missense_Mutation_p.V208L|ATRX_uc004ecr.2_Missense_Mutation_p.V384L|ATRX_uc010nlx.1_Missense_Mutation_p.V423L|ATRX_uc010nly.1_Missense_Mutation_p.V368L	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	423					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCTTTGTTTACAGCATCCATC	0.378000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						4	306					0	0	0.009096	0	0
STAG2	10735	broad.mit.edu	37	X	123176469	123176469	+	Nonsense_Mutation	SNP	C	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrX:123176469C>T	uc004etz.3	+	6	775	c.436C>T	c.(436-438)CGA>TGA	p.R146*	STAG2_uc004eua.2_Nonsense_Mutation_p.R146*|STAG2_uc004eub.2_Nonsense_Mutation_p.R146*|STAG2_uc004euc.2_Nonsense_Mutation_p.R146*|STAG2_uc004eud.2_Nonsense_Mutation_p.R146*|STAG2_uc004eue.2_Nonsense_Mutation_p.R146*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	146					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGAGATAATTCGAAAAATGAC	0.284000													72	10					0	0	0.014410	0	0
IL9R	3581	broad.mit.edu	37	X	155232601	155232601	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chrX:155232601G>A	uc004fnv.1	+	2	238	c.59G>A	c.(58-60)CGA>CAA	p.R20Q	IL9R_uc010nvn.2_5'UTR|IL9R_uc004fnu.1_Missense_Mutation_p.R67Q	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	20					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCCCTGAGGCGAGACATGGGC	0.612000													71	128					0	0	0.014410	0	0
UBXN11	91544	broad.mit.edu	37	1	26608820	26608843	+	In_Frame_Del	DEL	GGGACTGGGGCCGGGACCGGGACC	-	-	rs61775084	by1000genomes	TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:26608820_26608843delGGGACTGGGGCCGGGACCGGGACC	uc001blw.2	-	16	1783_1806	c.1510_1533delGGTCCCGGTCCCGGCCCCAGTCCC	c.(1510-1533)GGTCCCGGTCCCGGCCCCAGTCCCdel	p.GPGPGPSP504del	UBXN11_uc001blz.1_Splice_Site_p.I469_splice|UBXN11_uc001blv.2_In_Frame_Del_p.GPGPGPSP466del|UBXN11_uc001bly.2_In_Frame_Del_p.GPGPGPSP384del|UBXN11_uc001blx.2_In_Frame_Del_p.GPGPGPSP262del|UBXN11_uc001bma.2_In_Frame_Del_p.GPGPGPSP471del	NM_183008	NP_892120	Q5T124	UBX11_HUMAN	socius isoform 2	504_511	Pro-rich.					cytoplasm|cytoskeleton				ovary(1)	1						gtccaggacagggactggggccgggaccgggaccgggactgggg	0.312													8	116	---	---	---	---					
UBXN11	91544	broad.mit.edu	37	1	26608878	26608883	+	In_Frame_Del	DEL	CCGGGA	-	-	rs1134581		TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr1:26608878_26608883delCCGGGA	uc001blw.2	-	16	1743_1748	c.1470_1475delTCCCGG	c.(1468-1476)GGTCCCGGC>GGC	p.490_492GPG>G	UBXN11_uc001blz.1_In_Frame_Del_p.457_459GPG>G|UBXN11_uc001blv.2_In_Frame_Del_p.452_454GPG>G|UBXN11_uc001bly.2_In_Frame_Del_p.370_372GPG>G|UBXN11_uc001blx.2_In_Frame_Del_p.248_250GPG>G|UBXN11_uc001bma.2_In_Frame_Del_p.457_459GPG>G|UBXN11_uc001bmb.1_In_Frame_Del_p.490_492GPG>G	NM_183008	NP_892120	Q5T124	UBX11_HUMAN	socius isoform 2	490_492	Pro-rich.|3 X 8 AA tandem repeats of P-G-P-G-P-G-P- S.|1.		Missing.|Missing.			cytoplasm|cytoskeleton				ovary(1)	1						gggactggggccgggaccgggaccgg	0.282													50	126	---	---	---	---					
CORO1B	57175	broad.mit.edu	37	11	67207603	67207603	+	Frame_Shift_Del	DEL	C	-	-			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:67207603delC	uc001olj.1	-	7	1029	c.993delG	c.(991-993)AAGfs	p.K331fs	PTPRCAP_uc001oli.1_5'Flank|CORO1B_uc009yrs.1_RNA|CORO1B_uc001olk.1_Frame_Shift_Del_p.K331fs|CORO1B_uc009yrt.1_RNA|CORO1B_uc009yru.1_RNA|CORO1B_uc001oll.1_Frame_Shift_Del_p.K331fs	NM_020441	NP_065174	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	331					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CGATCTCGCACTTGCTGACCT	0.622													78	96	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	21847859	21847862	+	RNA	DEL	TATC	-	-			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:21847859_21847862delTATC	uc002diq.3	+	3		c.1752_1755delTATC			uc010vbm.1_5'UTR|uc002djn.3_Intron					Homo sapiens cDNA FLJ59829 complete cds.																		GTCTTGATGTTATCATCTGCTGAG	0.583													45	137	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	G	G	rs113730440		TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:26684394_26684395insG	uc002haz.2	-	2	210	c.78_splice	c.e2+1	p.W26_splice	POLDIP2_uc010wag.1_RNA|TMEM199_uc002hba.2_5'Flank|SARM1_uc010wah.1_5'Flank	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2							mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													10	5	---	---	---	---					
CD300A	11314	broad.mit.edu	37	17	72469708	72469709	+	Frame_Shift_Ins	INS	-	G	G			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr17:72469708_72469709insG	uc002jkv.2	+	2	395_396	c.74_75insG	c.(73-75)GCGfs	p.A25fs	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	25	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						AGGACCGTGGCGGGCCCCGTGG	0.569													7	674	---	---	---	---					
FANCD2	2177	broad.mit.edu	37	3	10088407	10088410	+	Splice_Site	DEL	AGTA	-	-	rs146316187		TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr3:10088407_10088410delAGTA	uc003buw.2	+	15	1356	c.1278_splice	c.e15+1	p.L426_splice	FANCD2_uc003bux.1_Splice_Site_p.L426_splice|FANCD2_uc003buy.1_Splice_Site_p.L426_splice|FANCD2_uc010hcw.1_5'Flank	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform						DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TTCATTACTTAGTAAGTGTCAGAG	0.235			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				25	82	---	---	---	---					
SMPD2	6610	broad.mit.edu	37	6	109763791	109763791	+	Frame_Shift_Del	DEL	C	-	-			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:109763791delC	uc003pti.2	+	6	848	c.454delC	c.(454-456)CGTfs	p.R152fs	PPIL6_uc003ptg.3_5'Flank|PPIL6_uc010kdo.2_5'Flank|PPIL6_uc010kdp.2_5'Flank|PPIL6_uc003pth.1_5'Flank	NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	152					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		CCTAGCACATCGTGTGGCCCA	0.537													100	148	---	---	---	---					
ODF1	4956	broad.mit.edu	37	8	103572984	103572992	+	In_Frame_Del	DEL	TGCAGCCCC	-	-	rs72175040	byFrequency	TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	23886794-9d4c-4511-82ee-830db88796d5	g.chr8:103572984_103572992delTGCAGCCCC	uc003ykt.2	+	2	733_741	c.625_633delTGCAGCCCC	c.(625-633)TGCAGCCCCdel	p.CSP215del		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	215_217	C-X-P repeat region.				cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			CACTTCTCCTtgcagcccctgcagcccct	0.364													17	102	---	---	---	---					
CORO1B	57175	broad.mit.edu	37	11	67207603	67207603	+	Frame_Shift_Del	DEL	C	-	-			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr11:67207603delC	uc001olj.1	-	7	1029	c.993delG	c.(991-993)AAGfs	p.K331fs	PTPRCAP_uc001oli.1_5'Flank|CORO1B_uc009yrs.1_RNA|CORO1B_uc001olk.1_Frame_Shift_Del_p.K331fs|CORO1B_uc009yrt.1_RNA|CORO1B_uc009yru.1_RNA|CORO1B_uc001oll.1_Frame_Shift_Del_p.K331fs	NM_020441	NP_065174	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	331					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CGATCTCGCACTTGCTGACCT	0.622													65	74	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	21847859	21847862	+	RNA	DEL	TATC	-	-			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr16:21847859_21847862delTATC	uc002diq.3	+	3		c.1752_1755delTATC			uc010vbm.1_5'UTR|uc002djn.3_Intron					Homo sapiens cDNA FLJ59829 complete cds.																		GTCTTGATGTTATCATCTGCTGAG	0.583													47	151	---	---	---	---					
SMPD2	6610	broad.mit.edu	37	6	109763791	109763791	+	Frame_Shift_Del	DEL	C	-	-			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:109763791delC	uc003pti.2	+	6	848	c.454delC	c.(454-456)CGTfs	p.R152fs	PPIL6_uc003ptg.3_5'Flank|PPIL6_uc010kdo.2_5'Flank|PPIL6_uc010kdp.2_5'Flank|PPIL6_uc003pth.1_5'Flank	NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	152					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		CCTAGCACATCGTGTGGCCCA	0.537													117	143	---	---	---	---					
GRM1	2911	broad.mit.edu	37	6	146350671	146350672	+	Frame_Shift_Ins	INS	-	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-10A-01D-1458-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	23886794-9d4c-4511-82ee-830db88796d5	g.chr6:146350671_146350672insT	uc010khw.1	+	2	488_489	c.18_19insT	c.(16-21)TTGTTTfs	p.L6fs	GRM1_uc010khu.1_Frame_Shift_Ins_p.L6fs|GRM1_uc010khv.1_Frame_Shift_Ins_p.L6fs|GRM1_uc003qll.2_Frame_Shift_Ins_p.L6fs|GRM1_uc011edz.1_Frame_Shift_Ins_p.L6fs|GRM1_uc011eea.1_Frame_Shift_Ins_p.L6fs	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	6_7					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGCTCCTTTTGTTTTTTTTCCC	0.644													8	363	---	---	---	---					
CORO1B	57175	broad.mit.edu	37	11	67207603	67207603	+	Frame_Shift_Del	DEL	C	-	-			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:67207603delC	uc001olj.1	-	7	1029	c.993delG	c.(991-993)AAGfs	p.K331fs	PTPRCAP_uc001oli.1_5'Flank|CORO1B_uc009yrs.1_RNA|CORO1B_uc001olk.1_Frame_Shift_Del_p.K331fs|CORO1B_uc009yrt.1_RNA|CORO1B_uc009yru.1_RNA|CORO1B_uc001oll.1_Frame_Shift_Del_p.K331fs	NM_020441	NP_065174	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	331					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CGATCTCGCACTTGCTGACCT	0.622													78	96	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	21847859	21847862	+	RNA	DEL	TATC	-	-			TCGA-B3-4104-01A-01D-1252-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	1acb9bbe-a10a-44f8-a959-4eee82714570	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:21847859_21847862delTATC	uc002diq.3	+	3		c.1752_1755delTATC			uc010vbm.1_5'UTR|uc002djn.3_Intron					Homo sapiens cDNA FLJ59829 complete cds.																		GTCTTGATGTTATCATCTGCTGAG	0.583													45	137	---	---	---	---					
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575213	+	Frame_Shift_Ins	INS	-	T	T			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr1:74575212_74575213insT	uc001dfy.3	-	5	924_925	c.732_733insA	c.(730-735)AAACAGfs	p.K244fs	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	244_245				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						ovary(2)	2						TTTTCCTGCTGTTTTTTTTTGT	0.327													8	197	---	---	---	---					
CORO1B	57175	broad.mit.edu	37	11	67207603	67207603	+	Frame_Shift_Del	DEL	C	-	-			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr11:67207603delC	uc001olj.1	-	7	1029	c.993delG	c.(991-993)AAGfs	p.K331fs	PTPRCAP_uc001oli.1_5'Flank|CORO1B_uc009yrs.1_RNA|CORO1B_uc001olk.1_Frame_Shift_Del_p.K331fs|CORO1B_uc009yrt.1_RNA|CORO1B_uc009yru.1_RNA|CORO1B_uc001oll.1_Frame_Shift_Del_p.K331fs	NM_020441	NP_065174	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	331					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CGATCTCGCACTTGCTGACCT	0.622													65	74	---	---	---	---					
SLTM	79811	broad.mit.edu	37	15	59182564	59182565	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr15:59182564_59182565delCT	uc002afp.2	-	15	2082_2083	c.1994_1995delAG	c.(1993-1995)GAGfs	p.E665fs	SLTM_uc002afn.2_Frame_Shift_Del_p.E207fs|SLTM_uc002afo.2_Frame_Shift_Del_p.E647fs|SLTM_uc002afq.2_Frame_Shift_Del_p.E234fs|SLTM_uc010bgd.2_Frame_Shift_Del_p.E234fs	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	665	Arg/Glu-rich.|Potential.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TTTCTAGGCGCTCTCTCTCTCT	0.475													10	396	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	21847859	21847862	+	RNA	DEL	TATC	-	-			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr16:21847859_21847862delTATC	uc002diq.3	+	3		c.1752_1755delTATC			uc010vbm.1_5'UTR|uc002djn.3_Intron					Homo sapiens cDNA FLJ59829 complete cds.																		GTCTTGATGTTATCATCTGCTGAG	0.583													47	151	---	---	---	---					
TDRD6	221400	broad.mit.edu	37	6	46660414	46660415	+	Frame_Shift_Ins	INS	-	A	A			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr6:46660414_46660415insA	uc003oyj.2	+	1	4549_4550	c.4549_4550insA	c.(4549-4551)GAAfs	p.E1517fs	TDRD6_uc010jze.2_Frame_Shift_Ins_p.E1511fs	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1517					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GTATAATCCAGAAAAAAAAATG	0.351													7	221	---	---	---	---					
ZNF367	195828	broad.mit.edu	37	9	99180257	99180258	+	In_Frame_Ins	INS	-	GGG	GGG			TCGA-B3-4104-01A-01D-1458-08	TCGA-B3-4104-11A-01D-1252-08									Somatic	Phase_I	Capture				Illumina GAIIx	368382d0-ad7f-4735-b04a-e806d2a2d9a4	30b05e92-5b2e-4c1c-9c29-cde6dc5a94e1	g.chr9:99180257_99180258insGGG	uc004awf.2	-	1	412_413	c.57_58insCCC	c.(55-60)insCCC	p.19_20insP	ZNF367_uc004awg.2_In_Frame_Ins_p.19_20insP	NM_153695	NP_710162	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	19_20	Pro-rich.				regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0167)				CAGAAGATGACGggcggcggcg	0.658													3	4	---	---	---	---					
