Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SRRM1	10250	broad.mit.edu	37	1	24979017	24979017	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr1:24979017A>T	uc001bjm.2	+	7	1042	c.818A>T	c.(817-819)AAG>ATG	p.K273M	SRRM1_uc010oel.1_Missense_Mutation_p.K273M|SRRM1_uc009vrh.1_Missense_Mutation_p.K234M|SRRM1_uc009vri.1_Missense_Mutation_p.K190M|SRRM1_uc010oem.1_RNA	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	273	Pro-rich.|Arg-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		GAGAAGGAGAAGACCCGACCA	0.502000													6	14					0	0	0.021553	0	0
PEF1	553115	broad.mit.edu	37	1	32100869	32100869	+	Silent	SNP	T	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr1:32100869T>C	uc001bth.1	-	2	291	c.279A>G	c.(277-279)CCA>CCG	p.P93P	PEF1_uc001bte.1_5'Flank|PEF1_uc001btf.1_5'Flank|PEF1_uc001btg.1_Silent_p.P23P|PEF1_uc010ogm.1_Silent_p.P93P	NM_012392	NP_036524	Q9UBV8	PEF1_HUMAN	penta-EF-hand domain containing 1	93	9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P.|8.				response to calcium ion	cytoplasm|membrane	calcium ion binding|protein heterodimerization activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)|all_neural(195;0.186)		STAD - Stomach adenocarcinoma(196;0.0546)		AACTTGGAGGTGGCTGACCAT	0.587000													19	60					0	0	0.038395	0	0
SLC1A7	6512	broad.mit.edu	37	1	53555558	53555558	+	Silent	SNP	G	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr1:53555558G>A	uc001cuy.2	-	9	1443	c.1275C>T	c.(1273-1275)GCC>GCT	p.A425A	SLC1A7_uc001cux.2_Silent_p.A78A	NM_006671	NP_006662	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter),	425	Helical; (Potential).					integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|large_intestine(1)	3				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	TGACGAGGCCGGCCTGGGGGA	0.627000													3	59					0	0	0.115264	0	0
NBPF10	100132406	broad.mit.edu	37	1	145360624	145360624	+	Silent	SNP	G	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr1:145360624G>A	uc001end.3	+	76	9509	c.9474G>A	c.(9472-9474)TCG>TCA	p.S3158S	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oyq.1_Intron|NBPF10_uc010oyr.1_Silent_p.S456S	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3083											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GATGTTATTCGACTCCTTCAG	0.478000													3	12					0	0	0.115264	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232650793	232650793	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr1:232650793A>C	uc001hvg.2	-	1	451	c.293T>G	c.(292-294)CTG>CGG	p.L98R		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	98					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GCTTTCCCACAGTGCCTTGCA	0.517000													31	121					0	0	0.054565	0	0
CUBN	8029	broad.mit.edu	37	10	16871011	16871011	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr10:16871011T>A	uc001ioo.2	-	66	10609	c.10557A>T	c.(10555-10557)AGA>AGT	p.R3519S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3519	CUB 27.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGAATGAGCCTCTGTCTCCAT	0.502000													8	27					0	0	0.058154	0	0
EPC1	80314	broad.mit.edu	37	10	32582651	32582651	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr10:32582651C>A	uc001iwg.1	-	3	598	c.328G>T	c.(328-330)GCT>TCT	p.A110S	EPC1_uc001iwi.3_Missense_Mutation_p.A60S|EPC1_uc009xlt.2_Missense_Mutation_p.A60S|EPC1_uc001iwh.1_Missense_Mutation_p.A110S	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	110					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)				GGCTGTTCAGCATCCAAACTA	0.368000													9	26					3.86212e-05	4.1035e-05	0.069234	1	0
ZNF33B	7582	broad.mit.edu	37	10	43088537	43088537	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr10:43088537T>G	uc001jaf.1	-	5	1976	c.1861A>C	c.(1861-1863)AAG>CAG	p.K621Q	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.K509Q|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	621	C2H2-type 11.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGTTGTGACTTCTGGCAGAAG	0.363000													37	123					0	0	0.086207	0	0
PDE6C	5146	broad.mit.edu	37	10	95400272	95400272	+	Silent	SNP	G	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr10:95400272G>A	uc001kiu.3	+	13	1833	c.1695G>A	c.(1693-1695)CGG>CGA	p.R565R		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	565				R -> Q (in Ref. 1; AAA96392 and 2; AAA92886).	visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				ACAATTGGCGGCATGGGTTCA	0.453000													4	156					0	0	0.029380	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110036283	110036283	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr11:110036283T>A	uc009yxw.2	+	6	2524	c.2473T>A	c.(2473-2475)TGT>AGT	p.C825S	ZC3H12C_uc010rwc.1_Missense_Mutation_p.C826S|ZC3H12C_uc010rwd.1_Missense_Mutation_p.C826S|ZC3H12C_uc001pkr.3_Missense_Mutation_p.C794S	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	825							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		GATCCCATACTGTGGAATGCC	0.502000													4	20					0	0	0.009096	0	0
ESPL1	9700	broad.mit.edu	37	12	53687097	53687097	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr12:53687097G>A	uc001sck.2	+	31	6293	c.6202G>A	c.(6202-6204)GAC>AAC	p.D2068N	ESPL1_uc001scj.2_Missense_Mutation_p.D1743N|PFDN5_uc001scl.2_5'Flank|PFDN5_uc001scm.2_5'Flank|PFDN5_uc001scn.2_5'Flank|PFDN5_uc001sco.2_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	2068					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GACTGACCGCGACATTGACCG	0.532000													3	54					0	0	0.115264	0	0
STAT2	6773	broad.mit.edu	37	12	56742947	56742947	+	Silent	SNP	C	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr12:56742947C>T	uc001slc.2	-	16	1518	c.1440G>A	c.(1438-1440)CAG>CAA	p.Q480Q	STAT2_uc001slb.2_Silent_p.Q22Q|STAT2_uc001sld.2_Silent_p.Q476Q|STAT2_uc010sqn.1_Intron	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	480					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						ACTCCCCTACCTGAAGGTTTG	0.562000													35	99					0	0	0.064281	0	0
GCN1L1	10985	broad.mit.edu	37	12	120616498	120616498	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr12:120616498G>A	uc001txo.2	-	7	603	c.590C>T	c.(589-591)GCT>GTT	p.A197V		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	197					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCATGCCAGCATAGTTCTG	0.557000													3	58					0	0	0.115264	0	0
FREM2	341640	broad.mit.edu	37	13	39265553	39265553	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr13:39265553A>G	uc001uwv.2	+	1	4381	c.4072A>G	c.(4072-4074)ACT>GCT	p.T1358A		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1358	Extracellular (Potential).|CSPG 9.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ACGAAAACCTACTGGTGCCTT	0.383000													20	62					0	0	0.043863	0	0
TPT1	7178	broad.mit.edu	37	13	45913688	45913688	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr13:45913688T>A	uc001uzy.1	-	4	436	c.343A>T	c.(343-345)ATG>TTG	p.M115L	TPT1_uc001uzz.1_Missense_Mutation_p.M81L|SNORA31_uc001vaa.1_5'Flank|LOC100190939_uc010tfr.1_5'Flank|LOC100190939_uc001vac.2_5'Flank	NM_003295	NP_003286	P13693	TCTP_HUMAN	tumor protein, translationally-controlled 1	115					anti-apoptosis|response to virus	extracellular space|multivesicular body	calcium ion binding|protein binding				0		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000232)		GCCCCTGTCATAAAAGGTTTT	0.328000													34	118					0	0	0.086207	0	0
MLNR	2862	broad.mit.edu	37	13	49796387	49796387	+	Silent	SNP	C	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr13:49796387C>G	uc010tgj.1	+	2	1113	c.1113C>G	c.(1111-1113)CTC>CTG	p.L371L		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	371	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		AACTGCTGCTCGCAAGGAAGT	0.547000													18	55					0	0	0.043863	0	0
HERC2P2	400322	broad.mit.edu	37	15	23312250	23312250	+	Missense_Mutation	SNP	A	G	G	rs139598302	by1000genomes	TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr15:23312250A>G	uc001yvr.2	-	19	2872	c.2672T>C	c.(2671-2673)GTG>GCG	p.V891A	HERC2P2_uc001yvq.2_5'Flank|HERC2P2_uc001yvo.3_5'Flank|HERC2P2_uc001yvp.3_Splice_Site					RecName: Full=Putative HERC2-like protein 3;												0						CATGTCCCTCACCCTTTCGGT	0.458000													3	23					0	0	0.115264	0	0
GOLGA6L5	374650	broad.mit.edu	37	15	85053142	85053142	+	RNA	SNP	C	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr15:85053142C>T	uc002bkm.2	-	9		c.1905G>A			uc002bkl.1_5'Flank	NR_003246				Homo sapiens cDNA FLJ33459 fis, clone BRAMY2000585.												0						TTTTTCAATTCCTTGACCCGC	0.393000													5	5					0	0	0.021553	0	0
WASH3P	374666	broad.mit.edu	37	15	102515344	102515344	+	Missense_Mutation	SNP	A	C	C	rs141089280	by1000genomes	TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr15:102515344A>C	uc002cdi.2	+	9	1988	c.568A>C	c.(568-570)AAG>CAG	p.K190Q	WASH3P_uc002cdl.2_Missense_Mutation_p.K190Q|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.K190Q|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						GCTGGAGAAGAAGCAGCAGAA	0.662000													3	25					0	0	0.115264	0	0
TSC2	7249	broad.mit.edu	37	16	2122849	2122849	+	Splice_Site	SNP	G	A	A	rs45517218		TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr16:2122849G>A	uc002con.2	+	21	2327	c.2221_splice	c.e21-1	p.L741_splice	TSC2_uc010bsd.2_Splice_Site_p.L741_splice|TSC2_uc002coo.2_Splice_Site_p.L741_splice|TSC2_uc010uvv.1_Splice_Site_p.L704_splice|TSC2_uc010uvw.1_Splice_Site_p.L692_splice|TSC2_uc002cop.2_Splice_Site_p.L541_splice	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1						cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				TTGGTCATCAGCTTTCAGGCC	0.627000			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				22	26					0	0	0.076483	0	0
Unknown	0	broad.mit.edu	37	16	15023280	15023280	+	Splice_Site	SNP	T	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr16:15023280T>C	uc010uzk.1	+	6	1123	c.847_splice	c.e6+2	p.G283_splice	NPIP_uc002dcx.3_Splice_Site					SubName: Full=cDNA FLJ57488, highly similar to Polycystin-1;																		CGCTGGCGGGTGAGGAGATCG	0.701000													4	18					0	0	0.058154	0	0
NCOR1	9611	broad.mit.edu	37	17	15973543	15973543	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr17:15973543C>A	uc002gpo.2	-	31	4689	c.4449G>T	c.(4447-4449)AGG>AGT	p.R1483S	NCOR1_uc002gpn.2_Missense_Mutation_p.R1499S|NCOR1_uc002gpp.1_Missense_Mutation_p.R1390S|NCOR1_uc002gpm.2_5'Flank|NCOR1_uc010vwb.1_Missense_Mutation_p.R67S|NCOR1_uc010coy.2_Missense_Mutation_p.R391S|NCOR1_uc010vwc.1_Missense_Mutation_p.R294S	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1483	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TCACAGGGGTCCTCCGTGCAC	0.483000													7	249					1.12685e-05	1.21628e-05	0.047766	1	0
SLC38A10	124565	broad.mit.edu	37	17	79220316	79220316	+	Silent	SNP	C	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr17:79220316C>T	uc002jzz.1	-	16	2775	c.2400G>A	c.(2398-2400)CAG>CAA	p.Q800Q	SLC38A10_uc002jzy.1_Silent_p.Q718Q	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	800					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CCAGGGAGCGCTGGTTAAGGT	0.682000													12	28					0	0	0.093190	0	0
ZNF532	55205	broad.mit.edu	37	18	56587630	56587630	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr18:56587630C>T	uc002lho.2	+	4	2658	c.2111C>T	c.(2110-2112)ACT>ATT	p.T704I	ZNF532_uc002lhp.2_Missense_Mutation_p.T702I|ZNF532_uc010xeg.1_Missense_Mutation_p.T702I|ZNF532_uc002lhr.2_Missense_Mutation_p.T702I|ZNF532_uc002lhs.2_Missense_Mutation_p.T702I	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	704					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TCAACTTCCACTCTTCAGAGC	0.473000													16	46					0	0	0.132662	0	0
CCNE1	898	broad.mit.edu	37	19	30308341	30308341	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr19:30308341A>G	uc002nsn.2	+	6	538	c.355A>G	c.(355-357)ATC>GTC	p.I119V	CCNE1_uc002nso.2_Missense_Mutation_p.I104V	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	119					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			AGTCTGGAAAATCATGTTAAA	0.423000													5	96					0	0	0.014758	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41800265	41800265	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr19:41800265C>G	uc002oqb.3	+	9	1578	c.1289C>G	c.(1288-1290)CCT>CGT	p.P430R	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.P330R|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.P330R|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.P430R|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.P316R|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.P330R|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.P330R|HNRNPUL1_uc010eho.2_Missense_Mutation_p.P330R|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.P330R|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.P286R|HNRNPUL1_uc010ehl.1_Missense_Mutation_p.P330R	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	430	Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						GTGGGCCTGCCTGCTGCTGGC	0.443000													15	44					0	0	0.119110	0	0
SOS1	6654	broad.mit.edu	37	2	39285904	39285904	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr2:39285904C>T	uc002rrk.3	-	3	296	c.255G>A	c.(253-255)TGG>TGA	p.W85*	SOS1_uc010ynr.1_RNA	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	85					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				CAGCTATTGCCCATTTATCAA	0.338000									Noonan_syndrome				27	67					0	0	0.116897	0	0
TANC1	85461	broad.mit.edu	37	2	160086335	160086335	+	Silent	SNP	C	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr2:160086335C>A	uc002uag.2	+	27	4672	c.4398C>A	c.(4396-4398)CCC>CCA	p.P1466P	TANC1_uc010zcm.1_3'UTR|TANC1_uc010fon.2_Silent_p.P310P	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1466						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AAACTTCTCCCCAGGAAGAAT	0.517000													31	87					4.2108e-06	4.6183e-06	0.144211	1	0
IRS1	3667	broad.mit.edu	37	2	227662872	227662872	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr2:227662872C>T	uc002voh.3	-	1	635	c.583G>A	c.(583-585)GTG>ATG	p.V195M		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	195	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		TTCAGCTTCACGAAGCTGATG	0.567000											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	55					0	0	0.055883	0	0
ZFP64	55734	broad.mit.edu	37	20	50769885	50769885	+	Silent	SNP	C	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr20:50769885C>T	uc002xwl.2	-	6	1195	c.846G>A	c.(844-846)TCG>TCA	p.S282S	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Silent_p.S280S|ZFP64_uc002xwn.2_Silent_p.S228S	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCTTCTCCCCCGAGTGCACCC	0.552000													14	25					0	0	0.105934	0	0
IFNGR2	3460	broad.mit.edu	37	21	34799207	34799207	+	Silent	SNP	A	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr21:34799207A>T	uc002yrp.3	+	4	1077	c.429A>T	c.(427-429)CCA>CCT	p.P143P	IFNGR2_uc002yrq.3_Silent_p.P162P|IFNGR2_uc010gma.2_Silent_p.P64P|IFNGR2_uc002yrr.3_Silent_p.P64P	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	143	Extracellular (Potential).|Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	TCGGGCCTCCAGAAAACATTG	0.373000													75	185					0	0	0.139131	0	0
MKL1	57591	broad.mit.edu	37	22	40813489	40813489	+	Silent	SNP	G	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr22:40813489G>A	uc003ayv.1	-	10	2280	c.2073C>T	c.(2071-2073)TCC>TCT	p.S691S	MKL1_uc003ayw.1_Silent_p.S691S|MKL1_uc010gye.1_Silent_p.S691S|MKL1_uc010gyf.1_Silent_p.S641S	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	691	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AGCCAGGCTGGGACGAGGGCT	0.692000			T	RBM15	acute megakaryocytic leukemia								2	5					0	0	0.115264	0	0
CPNE4	131034	broad.mit.edu	37	3	131254172	131254172	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr3:131254172G>A	uc003eok.2	-	16	1976	c.1541C>T	c.(1540-1542)GCA>GTA	p.A514V	CPNE4_uc011blq.1_Missense_Mutation_p.A532V|CPNE4_uc003eol.2_Missense_Mutation_p.A532V|CPNE4_uc003eom.2_Missense_Mutation_p.A514V|CPNE4_uc003eoj.2_Missense_Mutation_p.A65V	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	514										upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AGCTGGAGATGCCTGCAGGGA	0.453000													20	71					0	0	0.062417	0	0
TIFA	92610	broad.mit.edu	37	4	113199250	113199250	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr4:113199250T>G	uc003ial.2	-	2	605	c.323A>C	c.(322-324)AAA>ACA	p.K108T		NM_052864	NP_443096	Q96CG3	TIFA_HUMAN	TRAF-interacting protein with a	108							protein binding			breast(1)	1		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00172)		CAGGTCCATTTTATTTAGGTA	0.388000													11	30					0	0	0.105934	0	0
METTL14	57721	broad.mit.edu	37	4	119631350	119631350	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr4:119631350T>A	uc003icf.2	+	11	1380	c.1264T>A	c.(1264-1266)TCT>ACT	p.S422T	METTL14_uc003icg.2_Missense_Mutation_p.S384T	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	422	Gly-rich.					nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						AGGTGGAACTTCTGCTGGCCG	0.527000													14	67					0	0	0.119110	0	0
KIAA1109	84162	broad.mit.edu	37	4	123161284	123161284	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr4:123161284G>C	uc003ieh.2	+	27	4492	c.4447G>C	c.(4447-4449)GAA>CAA	p.E1483Q	KIAA1109_uc003iei.1_Missense_Mutation_p.E1236Q|KIAA1109_uc010ins.1_Missense_Mutation_p.E826Q|KIAA1109_uc003iek.2_Missense_Mutation_p.E102Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1483					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						ATATATTGTAGAAGGTGAGAA	0.398000													20	72					0	0	0.055883	0	0
ATG10	83734	broad.mit.edu	37	5	81474374	81474374	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr5:81474374C>A	uc003khs.2	+	6	850	c.421C>A	c.(421-423)CTA>ATA	p.L141I	ATG10_uc003khr.2_Missense_Mutation_p.L141I|ATG10_uc010jas.2_Missense_Mutation_p.L105I	NM_001131028	NP_001124500	Q9H0Y0	ATG10_HUMAN	APG10 autophagy 10-like	141					autophagy in response to ER overload|positive regulation of protein modification process|protein lipidation|protein modification by small protein conjugation|protein transport	cytoplasm	Atg12 ligase activity|protein binding				0		Lung NSC(167;0.0258)|all_lung(232;0.0294)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;9.94e-41)|Epithelial(54;6.3e-36)|all cancers(79;2.31e-30)		GATGCGACTGCTACAGGGACC	0.353000													9	44					1.08611e-07	1.21074e-07	0.080935	1	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607000													3	3					0	0	0.115264	0	0
WDR36	134430	broad.mit.edu	37	5	110428267	110428267	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr5:110428267G>T	uc003kpd.2	+	1	398	c.281G>T	c.(280-282)CGC>CTC	p.R94L	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	94					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GCGCTCAAGCGCCGGTTCTAT	0.567000													4	32					0.000602214	0.000620463	0.014758	1	0
ARHGAP26	23092	broad.mit.edu	37	5	142283206	142283206	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr5:142283206G>C	uc011dbj.1	+	8	839	c.804G>C	c.(802-804)ATG>ATC	p.M268I	ARHGAP26_uc003lmt.2_Missense_Mutation_p.M268I|ARHGAP26_uc003lmw.2_Missense_Mutation_p.M268I	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	268	PH.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTACACCATGGAGGGATACC	0.473000													9	39					0	0	0.058154	0	0
GABRB2	2561	broad.mit.edu	37	5	160753381	160753381	+	Silent	SNP	C	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr5:160753381C>G	uc003lys.1	-	10	1403	c.1185G>C	c.(1183-1185)CTG>CTC	p.L395L	GABRB2_uc011deh.1_Intron|GABRB2_uc003lyr.1_Intron|GABRB2_uc003lyt.1_Intron|GABRB2_uc010jiu.1_Intron	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	395	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TAACCGTATACAGAGAGAAAT	0.204000													4	89					0	0	0.009096	0	0
DOCK2	1794	broad.mit.edu	37	5	169477372	169477372	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr5:169477372G>C	uc003maf.2	+	41	4264	c.4184G>C	c.(4183-4185)GGA>GCA	p.G1395A	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.G887A	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1395	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTGCCCCGGGAGATGATGTG	0.562000													28	84					0	0	0.134883	0	0
F12	2161	broad.mit.edu	37	5	176831305	176831305	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr5:176831305G>A	uc003mgo.3	-	9	959	c.910C>T	c.(910-912)CCG>TCG	p.P304S	F12_uc011dfy.1_5'UTR|F12_uc003mgn.3_5'UTR|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	304	Pro-rich.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCGGGGTCGGAGGCGCCGCC	0.701000									Hereditary_Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	18					0	0	0.029380	0	0
MAML1	9794	broad.mit.edu	37	5	179193285	179193285	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr5:179193285G>T	uc003mkm.2	+	2	1537	c.1274G>T	c.(1273-1275)GGC>GTC	p.G425V	MAML1_uc003mkn.1_Missense_Mutation_p.G425V	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	425					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCAGCCCCGGGCCAGATGTCC	0.637000													6	170					0.000157383	0.000164647	0.038147	1	0
ZBTB9	221504	broad.mit.edu	37	6	33423041	33423041	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr6:33423041A>G	uc003oeq.2	+	2	432	c.164A>G	c.(163-165)CAG>CGG	p.Q55R		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	55	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCCTGGTGCAGGGCCGGGAA	0.552000													59	154					0	0	0.139131	0	0
EEF1A1	1915	broad.mit.edu	37	6	74229620	74229620	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr6:74229620T>C	uc003phi.2	-	1	167	c.130A>G	c.(130-132)AAG>GAG	p.K44E	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Missense_Mutation_p.K44E|EEF1A1_uc003phf.2_Missense_Mutation_p.K44E|EEF1A1_uc003phg.2_Missense_Mutation_p.K44E|EEF1A1_uc003phh.2_5'UTR|EEF1A1_uc003phj.2_Missense_Mutation_p.K44E|EEF1A1_uc003phk.2_Missense_Mutation_p.K44E|EEF1A1_uc003phl.2_Missense_Mutation_p.K44E|EEF1A1_uc003phm.1_RNA	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	44						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						GCAGCCTCCTTCTCAAATTTT	0.423000													12	125					0	0	0.093190	0	0
ZNF292	23036	broad.mit.edu	37	6	87964665	87964665	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr6:87964665T>C	uc003plm.3	+	8	1359	c.1318T>C	c.(1318-1320)TGG>CGG	p.W440R		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GAAAACTCAATGGCCCTTTGA	0.378000													3	27					0	0	0.009096	0	0
SEMA3A	10371	broad.mit.edu	37	7	83636753	83636753	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr7:83636753G>C	uc003uhz.2	-	10	1371	c.1056C>G	c.(1054-1056)TTC>TTG	p.F352L		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	352	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ATGGACCAAGGAACACCCTTC	0.453000													3	92					0	0	0.115264	0	0
ANKIB1	54467	broad.mit.edu	37	7	92019370	92019370	+	Silent	SNP	T	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr7:92019370T>C	uc003ulw.2	+	15	2368	c.1992T>C	c.(1990-1992)TAT>TAC	p.Y664Y	ANKIB1_uc010lew.1_5'UTR	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	664							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGTGTTCTTATCCATATGGAT	0.333000													27	79					0	0	0.108266	0	0
SLC26A5	375611	broad.mit.edu	37	7	103019735	103019735	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr7:103019735A>C	uc003vbz.2	-	16	1868	c.1632T>G	c.(1630-1632)ATT>ATG	p.I544M	SLC26A5_uc003vbt.1_Missense_Mutation_p.I544M|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.I512M|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	544	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TTGCATAGTAAATTGGTGCAT	0.318000													30	57					0	0	0.125774	0	0
UBE3C	9690	broad.mit.edu	37	7	157046775	157046775	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr7:157046775A>G	uc010lqs.2	+	20	3134	c.2822A>G	c.(2821-2823)CAG>CGG	p.Q941R	UBE3C_uc003wni.3_Missense_Mutation_p.Q304R	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	941	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		GCTTTCCGCCAGGGCCTTGCC	0.567000													19	33					0	0	0.049695	0	0
PDLIM2	64236	broad.mit.edu	37	8	22452077	22452077	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr8:22452077C>T	uc003xcc.1	+	10	1150	c.1016C>T	c.(1015-1017)TCA>TTA	p.S339L		NM_176871	NP_789847	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 isoform 1	Error:Variant_position_missing_in_Q96JY6_after_alignment						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		ATGAGATTGTCACTGGAAGCT	0.527000													8	120					0	0	0.058154	0	0
SLC7A13	157724	broad.mit.edu	37	8	87226722	87226722	+	Nonsense_Mutation	SNP	T	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr8:87226722T>A	uc003ydq.1	-	4	1431	c.1333A>T	c.(1333-1335)AGA>TGA	p.R445*	SLC7A13_uc003ydr.1_3'UTR	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	445	Cytoplasmic (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						CAAGCCAATCTTATTTTAAAA	0.348000													14	30					0	0	0.146539	0	0
ZHX2	22882	broad.mit.edu	37	8	123965936	123965936	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr8:123965936A>C	uc003ypk.1	+	3	2753	c.2186A>C	c.(2185-2187)CAA>CCA	p.Q729P		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	729						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GTGGTTCCACAATATTACAAG	0.527000													21	67					0	0	0.069288	0	0
FLJ43860	389690	broad.mit.edu	37	8	142477599	142477599	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr8:142477599G>A	uc003ywi.2	-	18	2303	c.2222C>T	c.(2221-2223)ACG>ATG	p.T741M	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	741							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GTCGATGGCCGTCCAGATGAG	0.662000													7	20					0	0	0.029380	0	0
KIAA0368	23392	broad.mit.edu	37	9	114178598	114178598	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr9:114178598A>G	uc004bfe.1	-	19	2252	c.2252T>C	c.(2251-2253)ATG>ACG	p.M751T	KIAA0368_uc010muc.1_Missense_Mutation_p.M573T	NM_001080398	NP_001073867			KIAA0368 protein												0						GGTCCCGGTCATGTACTTGAC	0.383000													10	30					0	0	0.093190	0	0
SFRS17A	8227	broad.mit.edu	37	X	1718090	1718090	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chrX:1718090A>T	uc004cqa.2	+	4	1113	c.917A>T	c.(916-918)CAA>CTA	p.Q306L	SFRS17A_uc010ncx.1_Missense_Mutation_p.Q306L|SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	306					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACAGGAAACAAAAGGAGCTG	0.577000													4	19					0	0	0.014758	0	0
CBARA1	10367	broad.mit.edu	37	10	74322786	74322786	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr10:74322786delA	uc001jtb.1	-	3	330	c.197delT	c.(196-198)CTAfs	p.L66fs		NM_006077	NP_006068	Q9BPX6	MICU1_HUMAN	calcium binding atopy-related autoantigen 1	66					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			ovary(1)	1						GTCACTTTTTAGGTTGTCTAC	0.398													7	32	---	---	---	---					
IFIT5	24138	broad.mit.edu	37	10	91178386	91178387	+	Frame_Shift_Ins	INS	-	GCTC	GCTC			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr10:91178386_91178387insGCTC	uc010qnh.1	+	2	1661_1662	c.1430_1431insGCTC	c.(1429-1431)GAGfs	p.E477fs	IFIT5_uc010qng.1_Frame_Shift_Ins_p.E429fs	NM_012420	NP_036552	Q13325	IFIT5_HUMAN	interferon-induced protein with	477							binding				0						GCTCTCTGTGAGCTCCGACTTT	0.371													11	104	---	---	---	---					
AMOTL1	154810	broad.mit.edu	37	11	94602565	94602565	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr11:94602565delC	uc001pfb.2	+	12	2861	c.2691delC	c.(2689-2691)GGCfs	p.G897fs	AMOTL1_uc001pfc.2_Frame_Shift_Del_p.G847fs	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	897						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CCAGCCGCGGCCGGCTGAGCA	0.647													3	4	---	---	---	---					
DENR	8562	broad.mit.edu	37	12	123253468	123253468	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr12:123253468delG	uc001uda.2	+	7	688	c.552delG	c.(550-552)GAGfs	p.E184fs	DENR_uc010tag.1_Intron|DENR_uc001udb.2_Frame_Shift_Del_p.E138fs	NM_003677	NP_003668	O43583	DENR_HUMAN	density-regulated protein	184							protein binding|translation initiation factor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.28e-05)|Epithelial(86;6.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.199)		AATGGCCAGAGGTGAGTGCAT	0.363													16	40	---	---	---	---					
LRP2	4036	broad.mit.edu	37	2	170034511	170034513	+	In_Frame_Del	DEL	GAT	-	-	rs80338752		TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr2:170034511_170034513delGAT	uc002ues.2	-	53	10406_10408	c.10193_10195delATC	c.(10192-10197)CATCGA>CGA	p.H3398del		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3398	LDL-receptor class B 33.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.R3399*(1)		ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACCGTGTGTCGATGGTGGCCCTC	0.424													18	38	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179514942	179514959	+	In_Frame_Del	DEL	TTTCCTCTTCAGGAGCAA	-	-			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr2:179514942_179514959delTTTCCTCTTCAGGAGCAA	uc010zfg.1	-	164	32671_32688	c.32447_32464delTTGCTCCTGAAGAGGAAA	c.(32446-32466)ATTGCTCCTGAAGAGGAAAAG>AAG	p.IAPEEE10816del	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_RNA|TTN_uc002umx.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11743_11748							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAACTGGCTTTTCCTCTTCAGGAGCAATTTCCTCTTC	0.381													3	6	---	---	---	---					
SUCNR1	56670	broad.mit.edu	37	3	151599109	151599110	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr3:151599109_151599110insT	uc003ezf.1	+	3	877_878	c.778_779insT	c.(778-780)CTGfs	p.L260fs		NM_033050	NP_149039	Q9BXA5	SUCR1_HUMAN	succinate receptor 1	260	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	CGCTTCACGCCTGGGGAGTTGG	0.490													13	245	---	---	---	---					
ZNF318	24149	broad.mit.edu	37	6	43333130	43333130	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr6:43333130delT	uc003oux.2	-	2	526	c.448delA	c.(448-450)ATCfs	p.I150fs	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	150					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CCAACAGTGATCCTTAAGCTC	0.473													25	48	---	---	---	---					
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	-	-			TCGA-BQ-5884-01A-11D-1589-08	TCGA-BQ-5884-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f2fe918-229b-4e08-a866-96bb1c6fc7d9	9f67477d-e1e3-4aa5-9789-db50e9359ddd	g.chr9:100616701_100616706delGCCGCC	uc004axu.2	+	1	1165_1170	c.505_510delGCCGCC	c.(505-510)GCCGCCdel	p.AA177del		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	177_178	Ala-rich.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.573													3	6	---	---	---	---					
