Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PHACTR4	65979	broad.mit.edu	37	1	28800653	28800653	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr1:28800653A>T	uc001bpw.2	+	7	1693	c.1411A>T	c.(1411-1413)ATG>TTG	p.M471L	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.M455L|PHACTR4_uc001bpy.2_Missense_Mutation_p.M481L	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	471							actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		CACTATTGAAATGCTAAAAGT	0.393000													17	157					0	0	0.033300	0	0
FAM151A	338094	broad.mit.edu	37	1	55077293	55077293	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr1:55077293A>C	uc001cxn.2	-	6	1058	c.926T>G	c.(925-927)TTC>TGC	p.F309C	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	309						integral to membrane					0						CAGCTGCTTGAACTGTGACAG	0.567000													9	123					0	0	0.004482	0	0
SSX2IP	117178	broad.mit.edu	37	1	85121610	85121610	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr1:85121610G>A	uc001dkh.2	-	12	1569	c.1294C>T	c.(1294-1296)CTC>TTC	p.L432F	SSX2IP_uc001dkf.2_Missense_Mutation_p.L404F|SSX2IP_uc001dkg.2_RNA|SSX2IP_uc010orz.1_Missense_Mutation_p.L405F|SSX2IP_uc001dki.2_Missense_Mutation_p.L432F|SSX2IP_uc010osa.1_Missense_Mutation_p.L405F|SSX2IP_uc001dkj.2_Missense_Mutation_p.L432F|SSX2IP_uc009wci.2_Intron|SSX2IP_uc001dkk.1_Missense_Mutation_p.L428F	NM_014021	NP_054740	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting	432	Potential.				cell adhesion	nucleus|protein complex				ovary(2)	2				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TCTTCTTTGAGACGTTCCTTT	0.388000													6	57					0	0	0.021553	0	0
TXNIP	10628	broad.mit.edu	37	1	145439917	145439917	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr1:145439917G>A	uc001enn.3	+	3	804	c.463G>A	c.(463-465)GAT>AAT	p.D155N	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.D100N	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	155					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAATACCCCTGATTTAATGGT	0.428000													16	134					0	0	0.024245	0	0
PYHIN1	149628	broad.mit.edu	37	1	158912063	158912063	+	Silent	SNP	T	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr1:158912063T>G	uc001ftb.2	+	5	1121	c.876T>G	c.(874-876)GCT>GCG	p.A292A	PYHIN1_uc001ftc.2_Silent_p.A283A|PYHIN1_uc001ftd.2_Silent_p.A292A|PYHIN1_uc001fte.2_Silent_p.A283A	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	292	HIN-200.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					TATCTGAAGCTGGTCCTGACC	0.353000													4	57					0	0	0.029380	0	0
CACNA1S	779	broad.mit.edu	37	1	201017795	201017795	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr1:201017795G>T	uc001gvv.2	-	36	4583	c.4356C>A	c.(4354-4356)AAC>AAA	p.N1452K		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1452	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCAGGGGCATGTTCATGCCCA	0.617000													6	58					8.12818e-05	9.18838e-05	0.029380	1	0
OR2T12	127064	broad.mit.edu	37	1	248458256	248458256	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr1:248458256A>G	uc010pzj.1	-	1	625	c.625T>C	c.(625-627)TTT>CTT	p.F209L		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATGAGGGAAAAGGGGACCAGG	0.547000													3	80					0	0	0.004672	0	0
STAM	8027	broad.mit.edu	37	10	17735224	17735225	+	Missense_Mutation	DNP	GC	AA	AA			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr10:17735224_17735225GC>AA	uc001ipj.1	+	6	664_665	c.448_449GC>AA	c.(448-450)GCA>AAA	p.A150K	STAM_uc010qcf.1_Missense_Mutation_p.A39K|STAM_uc009xjw.1_5'Flank	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	150					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						TTGTTAGGCTGCAGAACAAGCA	0.406000													8	97					0	0	0.004672	0	0
AGAP7	653268	broad.mit.edu	37	10	51465326	51465326	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr10:51465326T>G	uc001jio.2	-	7	1256	c.1130A>C	c.(1129-1131)AAG>ACG	p.K377T	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron	NM_001077685	NP_001071153	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	377	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						TAGGTGTTTCTTTTTATTGGC	0.522000													10	158					0	0	0.006214	0	0
KIAA1279	26128	broad.mit.edu	37	10	70775391	70775391	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr10:70775391C>T	uc001joy.2	+	7	1181	c.1085C>T	c.(1084-1086)GCT>GTT	p.A362V		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	362					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1						CGGAAAAAAGCTGTGCAGTTT	0.413000													9	111					0	0	0.006214	0	0
PTPRJ	5795	broad.mit.edu	37	11	48152110	48152110	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr11:48152110T>C	uc001ngp.3	+	8	1812	c.1457T>C	c.(1456-1458)ATC>ACC	p.I486T	PTPRJ_uc001ngo.3_Missense_Mutation_p.I486T	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	486	Extracellular (Potential).|Fibronectin type-III 5.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						CAGATGCATATCACACAGGAG	0.478000													6	43					0	0	0.021553	0	0
KAT5	10524	broad.mit.edu	37	11	65480307	65480307	+	Splice_Site	SNP	T	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr11:65480307T>A	uc001ofi.2	+	3	398	c.148_splice	c.e3+2	p.F50_splice	KAT5_uc001ofj.2_Splice_Site_p.F50_splice|KAT5_uc001ofk.2_Splice_Site_p.F83_splice|KAT5_uc010roo.1_Splice_Site_p.F83_splice|KAT5_uc001ofl.2_Splice_Site	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2						androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						ACATTGACTGTGAGTTCTGGG	0.547000													5	99					0	0	0.021553	0	0
NDUFV1	4723	broad.mit.edu	37	11	67379406	67379406	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr11:67379406C>A	uc001omj.2	+	8	1272	c.1119C>A	c.(1117-1119)TTC>TTA	p.F373L	NDUFV1_uc010rpv.1_Missense_Mutation_p.F272L|NDUFV1_uc001oml.2_Missense_Mutation_p.F366L|NDUFV1_uc001omk.3_Missense_Mutation_p.F364L|NDUFV1_uc009yrz.1_3'UTR|NDUFV1_uc010rpw.1_Missense_Mutation_p.F82L	NM_007103	NP_009034	P49821	NDUV1_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 1	373					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	TCATTGAGTTCTATAAGCACG	0.612000													10	79					1.76689e-08	2.08815e-08	0.006214	1	0
SLC26A10	65012	broad.mit.edu	37	12	58016635	58016635	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr12:58016635T>C	uc001spe.2	+	6	1168	c.857T>C	c.(856-858)ATT>ACT	p.I286T	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_5'Flank	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	286						integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					TCGCTGCCCATTGCACTGGTT	0.572000													12	81					0	0	0.013537	0	0
YEATS4	8089	broad.mit.edu	37	12	69759615	69759615	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr12:69759615A>C	uc001sux.2	+	4	505	c.284A>C	c.(283-285)GAA>GCA	p.E95A		NM_006530	NP_006521	O95619	YETS4_HUMAN	glioma-amplified sequence-41	95	YEATS.				histone H2A acetylation|histone H4 acetylation|mitosis|positive regulation of transcription, DNA-dependent|regulation of growth	NuA4 histone acetyltransferase complex|nuclear matrix	DNA binding|protein C-terminus binding|sequence-specific DNA binding transcription factor activity|structural constituent of cytoskeleton				0	all_epithelial(5;9.25e-35)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;6.89e-18)|BRCA - Breast invasive adenocarcinoma(5;3.14e-09)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			GGATGGGGTGAATTCGAAATA	0.279000													26	125					0	0	0.037714	0	0
KCNC2	3747	broad.mit.edu	37	12	75436984	75436984	+	Silent	SNP	G	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr12:75436984G>T	uc001sxg.1	-	5	2362	c.1818C>A	c.(1816-1818)GGC>GGA	p.G606G	KCNC2_uc009zry.2_Intron|KCNC2_uc001sxe.2_Intron|KCNC2_uc001sxf.2_Intron|KCNC2_uc010stw.1_Silent_p.G551G	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	606	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						TGCCTGCCAAGCCCGCTATGT	0.423000													6	69					8.12818e-05	9.18838e-05	0.029380	1	0
UBE3B	89910	broad.mit.edu	37	12	109939240	109939240	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr12:109939240C>T	uc001top.2	+	13	1786	c.1183C>T	c.(1183-1185)CGG>TGG	p.R395W	UBE3B_uc001toq.2_Missense_Mutation_p.R395W|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.R395W	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	395					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GCCTCTGATCCGGATCTTCTT	0.552000													31	166					0	0	0.034045	0	0
TNFRSF19	55504	broad.mit.edu	37	13	24243093	24243093	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr13:24243093A>C	uc001uov.1	+	9	1166	c.1102A>C	c.(1102-1104)AAC>CAC	p.N368H	TNFRSF19_uc001uot.2_Missense_Mutation_p.N368H|TNFRSF19_uc010tcu.1_Missense_Mutation_p.N236H|TNFRSF19_uc001uow.2_Missense_Mutation_p.N368H	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	368	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TCATTCTGAAAACTTTACAGC	0.413000													12	125					0	0	0.013537	0	0
CKAP2	26586	broad.mit.edu	37	13	53042426	53042426	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr13:53042426T>A	uc001vgv.2	+	7	1690	c.1493T>A	c.(1492-1494)ATG>AAG	p.M498K	CKAP2_uc001vgu.2_Missense_Mutation_p.M497K|CKAP2_uc010tha.1_Missense_Mutation_p.M449K	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	498					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		ATTGAAGAGATGCGACACACG	0.299000													3	36					0	0	0.009096	0	0
CLEC14A	161198	broad.mit.edu	37	14	38723829	38723829	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr14:38723829C>T	uc001wum.1	-	1	1746	c.1399G>A	c.(1399-1401)GGG>AGG	p.G467R		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	467	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCACAGTCCCCGACTTTCACC	0.597000													17	116					0	0	0.007413	0	0
C15orf2	23742	broad.mit.edu	37	15	24923231	24923231	+	Silent	SNP	T	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr15:24923231T>A	uc001ywo.2	+	1	2691	c.2217T>A	c.(2215-2217)ACT>ACA	p.T739T		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	739					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GCGGCAACACTGCCTCAGTCC	0.557000													18	176					0	0	0.008871	0	0
HERC2	8924	broad.mit.edu	37	15	28510872	28510872	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr15:28510872T>A	uc001zbj.2	-	14	1868	c.1762A>T	c.(1762-1764)AGT>TGT	p.S588C	HERC2_uc001zbl.1_Missense_Mutation_p.S283C	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	588	RCC1 2.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCGTCCTCACTGGAGCCTTCA	0.577000													10	70					0	0	0.006214	0	0
TMEM62	80021	broad.mit.edu	37	15	43426530	43426530	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr15:43426530A>G	uc001zqr.2	+	2	535	c.256A>G	c.(256-258)ATT>GTT	p.I86V	TMEM62_uc010bda.2_5'UTR	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	86						integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		TTCTGAAACTATTGACATCAT	0.507000													6	64					0	0	0.003080	0	0
FES	2242	broad.mit.edu	37	15	91438758	91438758	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr15:91438758G>T	uc002bpv.2	+	19	2535	c.2439G>T	c.(2437-2439)GAG>GAT	p.E813D	FES_uc010uqj.1_Missense_Mutation_p.E685D|FES_uc010uqk.1_Missense_Mutation_p.E795D|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.E672D|FES_uc002bpx.2_Missense_Mutation_p.E743D|FES_uc002bpy.2_Missense_Mutation_p.E755D	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	813	Protein kinase.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TCTACCAGGAGCTGCAGAGCA	0.642000													5	79					2.0095e-06	2.33942e-06	0.029380	1	0
DECR2	26063	broad.mit.edu	37	16	457438	457438	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr16:457438T>G	uc002chb.2	+	4	321	c.215T>G	c.(214-216)CTG>CGG	p.L72R	DECR2_uc002chc.2_5'UTR|DECR2_uc010bqv.2_5'UTR|DECR2_uc002chd.2_5'UTR|DECR2_uc002che.1_RNA	NM_020664	NP_065715	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2	72						peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding				0		Hepatocellular(16;0.00015)				GCCAGGAAGCTGGCTGGGGCC	0.652000													5	77					0	0	0.021553	0	0
TSC2	7249	broad.mit.edu	37	16	2126139	2126139	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr16:2126139T>C	uc002con.2	+	24	2816	c.2710T>C	c.(2710-2712)TTC>CTC	p.F904L	TSC2_uc010bsd.2_Missense_Mutation_p.F904L|TSC2_uc002coo.2_Missense_Mutation_p.F904L|TSC2_uc010uvv.1_Missense_Mutation_p.F867L|TSC2_uc010uvw.1_Missense_Mutation_p.F855L|TSC2_uc002cop.2_Missense_Mutation_p.F704L	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	904					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CCGCCTGCCCTTCCGGAAGGA	0.567000			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				11	68					0	0	0.013537	0	0
TAOK2	9344	broad.mit.edu	37	16	29994548	29994548	+	Silent	SNP	G	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr16:29994548G>A	uc002dva.1	+	12	1938	c.1155G>A	c.(1153-1155)GAG>GAA	p.E385E	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Silent_p.E385E|TAOK2_uc002dvc.1_Silent_p.E385E|TAOK2_uc010bzm.1_Silent_p.E392E|TAOK2_uc002dvd.1_Silent_p.E212E	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	385	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						aggaggaggaggaagaggagg	0.478000													3	57					0	0	0.004672	0	0
PRPF8	10594	broad.mit.edu	37	17	1564455	1564455	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr17:1564455A>T	uc002fte.2	-	28	4454	c.4340T>A	c.(4339-4341)GTT>GAT	p.V1447D		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1447						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CTGCTTCAAAACCTAGATGGC	0.547000													8	62					0	0	0.003080	0	0
NEURL4	84461	broad.mit.edu	37	17	7220554	7220554	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr17:7220554G>A	uc002gga.1	-	28	4461	c.4454C>T	c.(4453-4455)GCT>GTT	p.A1485V	GPS2_uc002gfv.1_5'Flank|GPS2_uc002gfw.1_5'Flank|GPS2_uc002gfx.1_5'Flank|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_5'UTR|NEURL4_uc002ggb.1_Missense_Mutation_p.A1483V	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	1485							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTCCGCCCCAGCATATTGAAG	0.647000													3	36					0	0	0.014758	0	0
CDRT15P	94158	broad.mit.edu	37	17	13927900	13927900	+	RNA	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr17:13927900T>C	uc002god.1	+	1		c.86T>C				NR_003261				Homo sapiens CMT1A duplicated region transcript 15 pseudogene (CDRT15P), non-coding RNA.												0						GAGCCTTTTCTGACGATGCCG	0.572000													3	39					0	0	0.021553	0	0
SCRN2	90507	broad.mit.edu	37	17	45915217	45915217	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr17:45915217T>C	uc002imd.2	-	8	1397	c.1271A>G	c.(1270-1272)TAT>TGT	p.Y424C	SCRN2_uc002imc.2_Missense_Mutation_p.Y432C|SCRN2_uc002imf.2_3'UTR|SCRN2_uc002ime.2_RNA	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	secernin 2 isoform 1	424					proteolysis		dipeptidase activity			ovary(1)	1						AGCTTACGCATAAGCCTGGCT	0.657000													6	31					0	0	0.003080	0	0
TEX2	55852	broad.mit.edu	37	17	62290509	62290509	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr17:62290509C>T	uc002jec.2	-	2	1242	c.1069G>A	c.(1069-1071)GGC>AGC	p.G357S	TEX2_uc002jed.2_Missense_Mutation_p.G357S|TEX2_uc002jee.2_Missense_Mutation_p.G357S	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	357					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CTTCCGTAGCCATCCCCCTCA	0.498000													11	90					0	0	0.008291	0	0
MYO1F	4542	broad.mit.edu	37	19	8604865	8604865	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr19:8604865T>G	uc002mkg.2	-	16	1772	c.1658A>C	c.(1657-1659)AAG>ACG	p.K553T		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	553	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GGGGCGCCCCTTCTTGTCTCC	0.632000													5	63					0	0	0.021553	0	0
SRBD1	55133	broad.mit.edu	37	2	45647009	45647009	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr2:45647009T>C	uc002rus.2	-	17	2150	c.2074A>G	c.(2074-2076)AAG>GAG	p.K692E	SRBD1_uc010yoc.1_Missense_Mutation_p.K211E	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	692					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AGTGTTGCCTTGAGTAAAGTC	0.383000													15	126					0	0	0.033300	0	0
EIF5B	9669	broad.mit.edu	37	2	99978207	99978207	+	Silent	SNP	A	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr2:99978207A>T	uc002tab.2	+	4	1027	c.843A>T	c.(841-843)GTA>GTT	p.V281V		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	281					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						AAGAAACTGTAAAATCCAAAG	0.388000													13	145					0	0	0.020292	0	0
SLC20A1	6574	broad.mit.edu	37	2	113404533	113404533	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr2:113404533A>T	uc002tib.2	+	2	574	c.128A>T	c.(127-129)GAT>GTT	p.D43V	uc010fkq.1_5'Flank	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	43	Extracellular (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						GGAGCCAATGATGTAGCAAAT	0.502000													9	79					0	0	0.004482	0	0
SLC20A1	6574	broad.mit.edu	37	2	113404573	113404573	+	Silent	SNP	A	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr2:113404573A>G	uc002tib.2	+	2	614	c.168A>G	c.(166-168)GTA>GTG	p.V56V	uc010fkq.1_5'Flank	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	56	Extracellular (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						GCTCAGGTGTAGTGACCCTGA	0.507000													5	63					0	0	0.014758	0	0
ERCC3	2071	broad.mit.edu	37	2	128050232	128050232	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr2:128050232T>A	uc002toh.1	-	3	520	c.425A>T	c.(424-426)AAG>ATG	p.K142M	ERCC3_uc002toe.1_5'Flank|ERCC3_uc002tof.1_Missense_Mutation_p.K78M|ERCC3_uc002tog.1_Missense_Mutation_p.K78M|ERCC3_uc010flx.1_Translation_Start_Site|ERCC3_uc010yzh.1_RNA|ERCC3_uc010fly.2_Missense_Mutation_p.S95C	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	142					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTTGCTGAGCTTCCTGAGGTA	0.493000			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				12	88					0	0	0.010729	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669022	234669022	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr2:234669022T>C	uc002vvb.2	+	1	104	c.89T>C	c.(88-90)ATA>ACA	p.I30T	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Missense_Mutation_p.I30T	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	30					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	GCTGGGAAGATACTGTTGATC	0.612000													5	36					0	0	0.014758	0	0
LOC728323	728323	broad.mit.edu	37	2	243056830	243056830	+	RNA	SNP	G	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr2:243056830G>A	uc010zpd.1	+	3		c.291G>A			LOC728323_uc010zpe.1_RNA|LOC728323_uc010zpf.1_RNA|LOC728323_uc010zpg.1_Intron	NR_024437				Homo sapiens cDNA FLJ60027 complete cds, moderately similar to F-box only protein 25.												0						CAATAATGAAGAGCATGAATA	0.269000													4	27					0	0	0.021553	0	0
CST7	8530	broad.mit.edu	37	20	24930141	24930141	+	Silent	SNP	C	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr20:24930141C>T	uc002wtx.1	+	1	276	c.66C>T	c.(64-66)GCC>GCT	p.A22A		NM_003650	NP_003641	O76096	CYTF_HUMAN	cystatin F	Error:Variant_position_missing_in_O76096_after_alignment					immune response	cytoplasm|extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1						CCCGGGCAGCCATGCGAGCGG	0.682000													5	51					0	0	0.029380	0	0
IL5RA	3568	broad.mit.edu	37	3	3143448	3143448	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr3:3143448G>A	uc011ask.1	-	6	939	c.295C>T	c.(295-297)CGG>TGG	p.R99W	IL5RA_uc010hbq.2_Missense_Mutation_p.R99W|IL5RA_uc010hbr.2_Missense_Mutation_p.R99W|IL5RA_uc010hbs.2_Missense_Mutation_p.R99W|IL5RA_uc011asl.1_Missense_Mutation_p.R99W|IL5RA_uc011asm.1_Missense_Mutation_p.R99W|IL5RA_uc010hbt.2_Missense_Mutation_p.R99W|IL5RA_uc011asn.1_Missense_Mutation_p.R99W|IL5RA_uc010hbu.2_Missense_Mutation_p.R99W	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	99	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		AGGATGGTCCGCACACTTGCT	0.463000													4	66					0	0	0.009096	0	0
PLCXD2	257068	broad.mit.edu	37	3	111432757	111432757	+	Silent	SNP	C	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr3:111432757C>T	uc003dya.2	+	3	1234	c.648C>T	c.(646-648)CCC>CCT	p.P216P	PLCXD2_uc003dyb.2_Silent_p.P216P|PLCXD2_uc003dxz.2_Silent_p.P216P	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	216					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						ACCACTGTCCCTTCTACAAGC	0.443000													12	72					0	0	0.013537	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169664290	169664290	+	RNA	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr3:169664290T>C	uc011bpp.1	-	2		c.3513A>G				NR_027622				Homo sapiens cDNA FLJ41016 fis, clone UTERU2018784.												0						CTTGTTGTCCTTGGCCACAAA	0.522000													6	63					0	0	0.021553	0	0
DRD5	1816	broad.mit.edu	37	4	9784079	9784079	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr4:9784079C>G	uc003gmb.3	+	1	822	c.426C>G	c.(424-426)ATC>ATG	p.I142M		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	142	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ACTGGGCCATCTCCAGGCCCT	0.597000													5	44					0	0	0.014758	0	0
C4orf14	84273	broad.mit.edu	37	4	57842784	57842784	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr4:57842784C>A	uc003hck.2	-	1	1043	c.968G>T	c.(967-969)GGA>GTA	p.G323V	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	323							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					CTCTTCCACTCCATAGCCGGT	0.612000													7	118					0.000157383	0.00017537	0.003080	1	0
OTUD4	54726	broad.mit.edu	37	4	146076795	146076795	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr4:146076795C>A	uc003ika.3	-	9	677	c.539G>T	c.(538-540)AGA>ATA	p.R180I	OTUD4_uc003ijz.3_Missense_Mutation_p.R179I	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	244							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AAGAACCTTTCTAGACAAAGG	0.358000													9	134					0.000274275	0.000297131	0.004482	1	0
CCT5	22948	broad.mit.edu	37	5	10261751	10261751	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr5:10261751T>G	uc003jeq.2	+	8	1244	c.1073T>G	c.(1072-1074)CTT>CGT	p.L358R	CCT5_uc011cmq.1_Missense_Mutation_p.L205R|CCT5_uc003jer.2_Missense_Mutation_p.L358R|CCT5_uc010its.2_Missense_Mutation_p.L358R|CCT5_uc011cmr.1_Missense_Mutation_p.L303R|CCT5_uc011cms.1_Missense_Mutation_p.L320R|CCT5_uc011cmt.1_Missense_Mutation_p.L265R	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	358					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						TTTGCTGGTCTTGTACAGGAG	0.498000													32	294					0	0	0.012213	0	0
GPR98	84059	broad.mit.edu	37	5	90052965	90052965	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr5:90052965T>A	uc003kju.2	+	57	12023	c.11927T>A	c.(11926-11928)TTT>TAT	p.F3976Y	GPR98_uc003kjt.2_Missense_Mutation_p.F1682Y|GPR98_uc003kjv.2_Missense_Mutation_p.F1576Y	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3976	Calx-beta 26.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATTCTTGAATTTGCAGATAAA	0.413000													4	39					0	0	0.009096	0	0
ARAP3	64411	broad.mit.edu	37	5	141033934	141033934	+	Silent	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr5:141033934T>C	uc003llm.2	-	33	4296	c.4218A>G	c.(4216-4218)CCA>CCG	p.P1406P	ARAP3_uc003lll.2_Silent_p.P357P|ARAP3_uc011dbe.1_Silent_p.P1055P|ARAP3_uc003lln.2_Silent_p.P1237P	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1406					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CCTCATACACTGGCTCCTCGT	0.577000													13	95					0	0	0.016723	0	0
FBXO38	81545	broad.mit.edu	37	5	147781650	147781650	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr5:147781650A>G	uc003lpf.1	+	4	488	c.368A>G	c.(367-369)CAT>CGT	p.H123R	FBXO38_uc003lpg.1_Missense_Mutation_p.H123R|FBXO38_uc003lph.2_Missense_Mutation_p.H123R	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	123						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTAAGGGGCCATGAGGCTTTT	0.458000													17	108					0	0	0.033300	0	0
RFX6	222546	broad.mit.edu	37	6	117241541	117241541	+	Silent	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr6:117241541T>C	uc003pxm.2	+	12	1314	c.1251T>C	c.(1249-1251)GAT>GAC	p.D417D		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	417					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						AAAGGGTTGATTTGAACAGCA	0.418000													21	205					0	0	0.010504	0	0
MAD1L1	8379	broad.mit.edu	37	7	1855740	1855740	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr7:1855740G>A	uc003slh.1	-	19	2389	c.2123C>T	c.(2122-2124)ACC>ATC	p.T708I	MAD1L1_uc003sle.1_Missense_Mutation_p.T437I|MAD1L1_uc003slf.1_Missense_Mutation_p.T708I|MAD1L1_uc003slg.1_Missense_Mutation_p.T708I|MAD1L1_uc010ksh.1_Missense_Mutation_p.T708I|MAD1L1_uc003sli.1_Missense_Mutation_p.T616I|MAD1L1_uc003sld.1_Missense_Mutation_p.T164I	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	708					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GAGCTCGAGGGTGAGCGAGCT	0.667000													13	49					0	0	0.016723	0	0
GLI3	2737	broad.mit.edu	37	7	42004728	42004728	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr7:42004728G>T	uc011kbh.1	-	15	4034	c.3943C>A	c.(3943-3945)CAG>AAG	p.Q1315K	GLI3_uc011kbg.1_Missense_Mutation_p.Q1256K	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1315					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ACTGGGTCCTGGTTCTGCATG	0.652000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				5	76					0.000602214	0.000643462	0.014758	1	0
SPDYE7P	441251	broad.mit.edu	37	7	72339497	72339497	+	RNA	SNP	T	C	C	rs390732	by1000genomes	TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr7:72339497T>C	uc010lal.1	-	1		c.159A>G				NR_003666				Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.												0						TCCTCAGATTTGTCCCACCAC	0.582000													3	57					0	0	0.004672	0	0
CALCR	799	broad.mit.edu	37	7	93055856	93055856	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr7:93055856A>G	uc003umv.1	-	15	1600	c.1339T>C	c.(1339-1341)TGG>CGG	p.W447R	CALCR_uc011kia.1_Missense_Mutation_p.W227R|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.W413R|CALCR_uc003umw.2_Missense_Mutation_p.W413R	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	429	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CGCTGGTTCCACTGAATTTTG	0.542000													13	107					0	0	0.013537	0	0
EPHB6	2051	broad.mit.edu	37	7	142562311	142562311	+	Silent	SNP	G	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr7:142562311G>T	uc011kst.1	+	7	1540	c.753G>T	c.(751-753)GGG>GGT	p.G251G	EPHB6_uc011ksu.1_Silent_p.G251G|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_5'UTR|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	251	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GTGGGGCTGGGGGGGCCTCCC	0.682000													30	159					2.08457e-15	2.50148e-15	0.010818	1	0
FBXO16	157574	broad.mit.edu	37	8	28321296	28321296	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr8:28321296T>G	uc003xgu.2	-	4	273	c.175A>C	c.(175-177)ACA>CCA	p.T59P	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.T46P|FBXO16_uc003xgw.2_Missense_Mutation_p.T46P	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	59										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		AACAGGCCTGTGAGGATTCTT	0.443000													9	58					0	0	0.004482	0	0
PDP1	54704	broad.mit.edu	37	8	94935503	94935503	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr8:94935503T>A	uc003yge.2	+	2	1485	c.1216T>A	c.(1216-1218)TTA>ATA	p.L406I	PDP1_uc003ygf.2_Missense_Mutation_p.L431I|PDP1_uc010max.2_Missense_Mutation_p.L431I|PDP1_uc011lgm.1_Missense_Mutation_p.L406I|PDP1_uc011lgn.1_Missense_Mutation_p.L465I	NM_018444	NP_060914	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic	406					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						TTACCACCGATTAAGGCCACA	0.458000													12	129					0	0	0.013537	0	0
NFIB	4781	broad.mit.edu	37	9	14307404	14307404	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr9:14307404A>T	uc003zle.2	-	2	581	c.146T>A	c.(145-147)ATG>AAG	p.M49K	NFIB_uc003zlf.2_Missense_Mutation_p.M49K|NFIB_uc011lmo.1_Missense_Mutation_p.M49K	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	49	CTF/NF-I.				anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		ATCCTTTGACATTCGCTTCTC	0.453000			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								6	79					0	0	0.021553	0	0
GAPVD1	26130	broad.mit.edu	37	9	128117986	128117986	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr9:128117986T>A	uc010mwx.2	+	25	4201	c.3875T>A	c.(3874-3876)CTT>CAT	p.L1292H	GAPVD1_uc004bpp.2_Missense_Mutation_p.L1301H|GAPVD1_uc004bpq.2_Missense_Mutation_p.L1274H|GAPVD1_uc004bpr.2_Missense_Mutation_p.L1253H|GAPVD1_uc004bps.2_Missense_Mutation_p.L1247H|GAPVD1_uc004bpt.2_Missense_Mutation_p.L307H	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1292					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CTGCAGTTTCTTTATGGTGCA	0.408000													5	53					0	0	0.029380	0	0
Unknown	0	broad.mit.edu	37	MT	10705	10705	+	RNA	SNP	T	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chrM:10705T>C	uc004cov.3	+	1		c.128T>C			uc004cow.1_5'Flank|uc004cox.3_5'Flank					Homo sapiens potential LAG1 interactor mRNA, partial cds.																		AGCCCTACTAGTCTCAATCTC	0.458000													3	83					0	0	0.004672	0	0
GPRASP1	9737	broad.mit.edu	37	X	101910683	101910683	+	Silent	SNP	G	C	C			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chrX:101910683G>C	uc004ejj.3	+	5	2643	c.1842G>C	c.(1840-1842)GGG>GGC	p.G614G	GPRASP1_uc004eji.3_Silent_p.G614G|GPRASP1_uc010nod.2_Silent_p.G614G	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	614	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						CCATTATTGGGTCCTGGTTTT	0.512000													21	112					0	0	0.012319	0	0
F8	2157	broad.mit.edu	37	X	154157883	154157883	+	Silent	SNP	C	T	T			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chrX:154157883C>T	uc004fmt.2	-	14	4353	c.4182G>A	c.(4180-4182)ACG>ACA	p.T1394T		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1394	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TATGACTCCTCGTAAGGCAAT	0.428000													25	99					0	0	0.018920	0	0
INSRR	3645	broad.mit.edu	37	1	156816378	156816378	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr1:156816378delG	uc010pht.1	-	8	1997	c.1743delC	c.(1741-1743)ACCfs	p.T581fs	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	581	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCTCCTCAGTGGTTAGCGTGA	0.607													7	70	---	---	---	---					
SFRS2IP	9169	broad.mit.edu	37	12	46320707	46320708	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr12:46320707_46320708delTC	uc001rox.2	-	11	3063_3064	c.2776_2777delGA	c.(2776-2778)GAAfs	p.E926fs	SFRS2IP_uc001row.2_Frame_Shift_Del_p.E611fs|SFRS2IP_uc001roy.1_Frame_Shift_Del_p.E1000fs	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	926	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		GGTTCTCCTTTCTCTCTCTCTC	0.446													8	302	---	---	---	---					
MYH10	4628	broad.mit.edu	37	17	8452026	8452026	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr17:8452026delT	uc002gll.2	-	9	1065	c.969delA	c.(967-969)AAAfs	p.K323fs	MYH10_uc002glm.2_Frame_Shift_Del_p.K333fs|MYH10_uc010cnx.2_Frame_Shift_Del_p.K332fs|MYH10_uc010cny.1_RNA	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	323	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GGAAATTATCTTTGTCTTGCT	0.383													19	195	---	---	---	---					
PRPSAP1	5635	broad.mit.edu	37	17	74307703	74307703	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr17:74307703delT	uc010wta.1	-	10	1524	c.1078delA	c.(1078-1080)ATTfs	p.I360fs	PRPSAP1_uc010wtb.1_Frame_Shift_Del_p.I257fs	NM_002766	NP_002757	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate	331					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			ovary(1)	1						TCAGAAAGAATCAAACTGATA	0.468													10	89	---	---	---	---					
LYAR	55646	broad.mit.edu	37	4	4276371	4276375	+	Frame_Shift_Del	DEL	CTTCA	-	-			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr4:4276371_4276375delCTTCA	uc011bvy.1	-	7	694_698	c.551_555delTGAAG	c.(550-555)GTGAAGfs	p.V184fs	LYAR_uc011bvx.1_Frame_Shift_Del_p.V67fs|LYAR_uc003ght.2_Frame_Shift_Del_p.V184fs	NM_001145725	NP_001139197	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive homolog	184_185	Potential.|Lys-rich.					nucleolus	metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ttttATTCTTCTTCACCTCCCCTTG	0.361													13	166	---	---	---	---					
SNX30	401548	broad.mit.edu	37	9	115567070	115567071	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BQ-5889-01A-11D-1589-08	TCGA-BQ-5889-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	46b1253a-f381-46d3-ad7d-e0ed2bda9eff	fc277028-a6e0-4459-8608-40506e4c36cb	g.chr9:115567070_115567071insA	uc004bgj.3	+	2	319_320	c.171_172insA	c.(169-174)CCCAACfs	p.P57fs		NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	57_58					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						TCATTTTGCCCAACGGTGGTAC	0.401													27	241	---	---	---	---					
