Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
CROCCL1	84809	broad.mit.edu	37	1	16946437	16946437	+	RNA	SNP	C	T	T	rs2262202		TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr1:16946437C>T	uc010ocf.1	-	3		c.461G>A			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						AGCCTTCCGCCGGGCCAGCAG	0.672000													7	14					0	0	0.003080	0	0	
SNIP1	79753	broad.mit.edu	37	1	38003386	38003386	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr1:38003386T>A	uc001cbi.2	-	4	1227	c.1154A>T	c.(1153-1155)GAG>GTG	p.E385V	SNIP1_uc010oid.1_RNA	NM_024700	NP_078976	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein	385	Poly-Glu.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			upper_aerodigestive_tract(1)|lung(1)	2		Myeloproliferative disorder(586;0.0393)				CTCCTCATCCTCGTCATCTTT	0.423000													24	111					0	0	0.007291	0	0	
NBPF10	100132406	broad.mit.edu	37	1	145359169	145359169	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr1:145359169T>A	uc001end.3	+	74	9369	c.9334T>A	c.(9334-9336)TTG>ATG	p.L3112M	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oyq.1_Intron|NBPF10_uc010oyr.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3037											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCGTGTTGGCTTGGCTGTTGA	0.458000													6	251					0	0	0.001168	0	0	
FCRL3	115352	broad.mit.edu	37	1	157665941	157665941	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr1:157665941C>T	uc001frb.2	-	7	1313	c.1021G>A	c.(1021-1023)GCA>ACA	p.A341T	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.A341T|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.A67T|FCRL3_uc001frc.1_Missense_Mutation_p.A341T	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	341	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TGCAGCTCTGCCAACAGGGAA	0.522000													13	74					0	0	0.002450	0	0	
RABGAP1L	9910	broad.mit.edu	37	1	174926639	174926639	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr1:174926639A>G	uc001gjx.2	+	20	2581	c.2386A>G	c.(2386-2388)ATG>GTG	p.M796V	RABGAP1L_uc001gkb.3_5'UTR|RABGAP1L_uc001gkc.3_Missense_Mutation_p.M103V|RABGAP1L_uc001gkd.3_Missense_Mutation_p.M122V|RABGAP1L_uc001gke.3_Missense_Mutation_p.M115V|RABGAP1L_uc001gkf.2_Missense_Mutation_p.M53V|RABGAP1L_uc001gkg.2_Missense_Mutation_p.M53V|RABGAP1L_uc001gkh.3_Missense_Mutation_p.M53V	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	796					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						ATATCAGACAATGCGAGAGAG	0.353000													7	50					0	0	0.008291	0	0	
SMYD3	64754	broad.mit.edu	37	1	245927347	245927347	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr1:245927347C>G	uc001ibl.2	-	11	1276	c.1181G>C	c.(1180-1182)AGA>ACA	p.R394T	SMYD3_uc001ibk.2_Missense_Mutation_p.R335T|SMYD3_uc001ibi.2_Missense_Mutation_p.E206D|SMYD3_uc001ibj.2_Missense_Mutation_p.R205T	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	394						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		ACTCACCAGTCTCAGATTCTT	0.468000													10	79					0	0	0.001368	0	0	
CUBN	8029	broad.mit.edu	37	10	17152954	17152954	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr10:17152954T>A	uc001ioo.2	-	9	1031	c.979A>T	c.(979-981)ACA>TCA	p.T327S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	327	EGF-like 4; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GACCCAGGTGTATTCACACAC	0.522000													22	58					0	0	0.002780	0	0	
GDF10	2662	broad.mit.edu	37	10	48438519	48438519	+	Silent	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr10:48438519G>A	uc001jfb.2	-	1	648	c.192C>T	c.(190-192)GCC>GCT	p.A64A	GDF10_uc009xnp.2_Silent_p.A64A|GDF10_uc009xnq.1_Silent_p.A64A	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	64					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CCAACGTGGCGGCCGCGTCCC	0.746000													3	8					0	0	0.004672	0	0	
A1CF	29974	broad.mit.edu	37	10	52596017	52596017	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr10:52596017C>A	uc001jjj.2	-	6	609	c.421G>T	c.(421-423)GGG>TGG	p.G141W	A1CF_uc010qhn.1_Missense_Mutation_p.G149W|A1CF_uc001jji.2_Missense_Mutation_p.G141W|A1CF_uc001jjh.2_Missense_Mutation_p.G149W|A1CF_uc010qho.1_Missense_Mutation_p.G149W|A1CF_uc009xov.2_Missense_Mutation_p.G141W	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	141	RRM 2.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						GGGATGCCCCCAACAAATAAT	0.453000													27	86					4.72057e-08	6.99344e-08	0.003954	1	0	
SGPL1	8879	broad.mit.edu	37	10	72629560	72629560	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr10:72629560A>C	uc001jrm.2	+	9	938	c.716A>C	c.(715-717)CAA>CCA	p.Q239P	SGPL1_uc009xqk.2_RNA	NM_003901	NP_003892	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	239	Cytoplasmic (Potential).				apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity				0					Pyridoxal Phosphate(DB00114)	GTGGCTCCCCAAAGTGCCCAT	0.453000													6	50					0	0	0.002450	0	0	
POLR3A	11128	broad.mit.edu	37	10	79789149	79789149	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr10:79789149A>C	uc001jzn.2	-	1	111	c.17T>G	c.(16-18)TTC>TGC	p.F6C		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	6					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			CGTCTCCCGGAACTGCTCCTT	0.602000											OREG0020298	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	52					0	0	0.001984	0	0	
LOC440040	440040	broad.mit.edu	37	11	49597912	49597912	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr11:49597912G>A	uc010rhy.1	+	2	503	c.25G>A	c.(25-27)GCT>ACT	p.A9T	LOC440040_uc009ymb.2_Missense_Mutation_p.A9T	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						CATTATTGGAGCTCTCTTTTC	0.507000													7	41					0	0	0.001984	0	0	
ALDH3B2	222	broad.mit.edu	37	11	67431918	67431918	+	Silent	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr11:67431918G>A	uc001omr.2	-	8	1261	c.822C>T	c.(820-822)ATC>ATT	p.I274I	ALDH3B2_uc001oms.2_Silent_p.I274I|ALDH3B2_uc009ysa.1_Silent_p.I274I	NM_000695	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3B2	274					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			lung(1)|kidney(1)	2					NADH(DB00157)	CCTGCCGGTTGATGAACTTGA	0.642000													7	116					0	0	0.006214	0	0	
ALDH3B2	222	broad.mit.edu	37	11	67431927	67431927	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr11:67431927G>C	uc001omr.2	-	8	1252	c.813C>G	c.(811-813)ATC>ATG	p.I271M	ALDH3B2_uc001oms.2_Missense_Mutation_p.I271M|ALDH3B2_uc009ysa.1_Missense_Mutation_p.I271M	NM_000695	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3B2	271					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			lung(1)|kidney(1)	2					NADH(DB00157)	TGATGAACTTGATGGCCTCGT	0.647000													7	118					0	0	0.004482	0	0	
ALDH3B2	222	broad.mit.edu	37	11	67431978	67431978	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr11:67431978G>C	uc001omr.2	-	8	1201	c.762C>G	c.(760-762)ATC>ATG	p.I254M	ALDH3B2_uc001oms.2_Missense_Mutation_p.I254M|ALDH3B2_uc009ysa.1_Missense_Mutation_p.I254M	NM_000695	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3B2	254					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			lung(1)|kidney(1)	2					NADH(DB00157)	TGGGCCCGAAGATCTCCTCCT	0.652000													6	93					0	0	0.003080	0	0	
ATM	472	broad.mit.edu	37	11	108218089	108218089	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr11:108218089C>G	uc001pkb.1	+	59	9053	c.8668C>G	c.(8668-8670)CTA>GTA	p.L2890V	ATM_uc009yxr.1_Missense_Mutation_p.L2890V|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.L1542V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2890	PI3K/PI4K.		L -> V (in T-prolymphocytic leukemia).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.L2890V(2)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ACATATAGATCTAGGTAAGTA	0.313000			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			15	48					0	0	0.003163	0	0	
PPP2R1B	5519	broad.mit.edu	37	11	111613304	111613304	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr11:111613304T>A	uc001plx.1	-	13	1724	c.1640A>T	c.(1639-1641)AAT>ATT	p.N547I	PPP2R1B_uc001plw.1_Missense_Mutation_p.N547I|PPP2R1B_uc010rwi.1_Missense_Mutation_p.N483I|PPP2R1B_uc010rwj.1_Missense_Mutation_p.N386I|PPP2R1B_uc010rwk.1_Missense_Mutation_p.N502I|PPP2R1B_uc010rwl.1_Missense_Mutation_p.N420I	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	547	HEAT 14.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		GAAGCGAACATTTGCTACTTG	0.368000													11	35					0	0	0.008291	0	0	
NLRX1	79671	broad.mit.edu	37	11	119045756	119045756	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr11:119045756G>A	uc001pvu.2	+	6	1659	c.1444G>A	c.(1444-1446)GTG>ATG	p.V482M	NLRX1_uc010rzc.1_Missense_Mutation_p.V304M|NLRX1_uc001pvv.2_Missense_Mutation_p.V482M|NLRX1_uc001pvw.2_Missense_Mutation_p.V482M|NLRX1_uc001pvx.2_Missense_Mutation_p.V482M	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	482	Required for interaction with MAVS.|NACHT.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGCCCCATGTGTGGAGCCAGG	0.612000													10	51					0	0	0.006214	0	0	
IL23A	51561	broad.mit.edu	37	12	56733273	56733273	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr12:56733273G>A	uc001sla.2	+	2	392	c.226G>A	c.(226-228)GGC>AGC	p.G76S		NM_016584	NP_057668	Q9NPF7	IL23A_HUMAN	interleukin 23, alpha subunit p19 precursor	76					defense response to Gram-negative bacterium|inflammatory response|innate immune response|negative regulation of interleukin-10 production|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to virus|tissue remodeling	interleukin-23 complex	cytokine activity				0						GTGTGGAGATGGCTGTGACCC	0.502000													17	72					0	0	0.006122	0	0	
ATP5B	506	broad.mit.edu	37	12	57033084	57033084	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr12:57033084T>C	uc001slr.2	-	9	1400	c.1295A>G	c.(1294-1296)AAA>AGA	p.K432R	BAZ2A_uc001slq.1_5'Flank|BAZ2A_uc010sqr.1_5'Flank	NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	432					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						CTGGAGGGATTTGTAGTCCTA	0.428000													17	55					0	0	0.006122	0	0	
NCOR2	9612	broad.mit.edu	37	12	124904591	124904591	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr12:124904591T>C	uc010tba.1	-	13	1511	c.1394A>G	c.(1393-1395)GAG>GGG	p.E465G	NCOR2_uc010tay.1_Missense_Mutation_p.E465G|NCOR2_uc010taz.1_Missense_Mutation_p.E465G|NCOR2_uc010tbb.1_Missense_Mutation_p.E465G|NCOR2_uc010tbc.1_Missense_Mutation_p.E464G|NCOR2_uc001ugj.1_Missense_Mutation_p.E465G|NCOR2_uc001ugk.1_Missense_Mutation_p.E465G	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	465	SANT 1.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GAGGACGCACTCAGCCACTGT	0.388000													11	92					0	0	0.004656	0	0	
UBC	7316	broad.mit.edu	37	12	125398003	125398003	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr12:125398003C>G	uc001ugs.3	-	2	763	c.315G>C	c.(313-315)AAG>AAC	p.K105N	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.K105N|UBC_uc001ugt.2_Missense_Mutation_p.K105N|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_5'UTR	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	105	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGTCCTGGATCTTTGCTTTGA	0.532000													50	248					0	0	0.003610	0	0	
TUBA3C	7278	broad.mit.edu	37	13	19751365	19751365	+	Missense_Mutation	SNP	G	A	A	rs139914455		TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr13:19751365G>A	uc009zzj.2	-	4	807	c.758C>T	c.(757-759)ACG>ATG	p.T253M		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	253					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity	p.T253T(1)		ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CTGGAATTCCGTCAAGTCCAC	0.617000													24	141					0	0	0.003954	0	0	
NBEA	26960	broad.mit.edu	37	13	35770041	35770041	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr13:35770041A>C	uc001uvb.2	+	31	5174	c.4968A>C	c.(4966-4968)GAA>GAC	p.E1656D	NBEA_uc010abi.2_Missense_Mutation_p.E312D	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1656						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AAGAAAAAGAAACACCAACTC	0.378000													18	196					0	0	0.001523	0	0	
NALCN	259232	broad.mit.edu	37	13	101936302	101936302	+	Silent	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr13:101936302G>A	uc001vox.1	-	10	1305	c.1116C>T	c.(1114-1116)CGC>CGT	p.R372R	NALCN_uc001voy.2_Silent_p.R87R|NALCN_uc001voz.2_Silent_p.R372R|NALCN_uc001vpa.2_Silent_p.R372R	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	372	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGGCTGGGGCGCGTCCCTGGG	0.468000													12	30					0	0	0.004990	0	0	
HCN4	10021	broad.mit.edu	37	15	73635776	73635776	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr15:73635776G>A	uc002avp.2	-	2	2153	c.1159C>T	c.(1159-1161)CGC>TGC	p.R387C		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	387	Helical; Voltage-sensor; Name=Segment S4; (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CGTAACAGGCGTAAGAGGCTG	0.562000													11	46					0	0	0.003163	0	0	
Unknown	0	broad.mit.edu	37	15	102292785	102292785	+	Missense_Mutation	SNP	C	G	G	rs143389223		TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr15:102292785C>G	uc010usj.1	+	4	432	c.373C>G	c.(373-375)CAG>GAG	p.Q125E	uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;																		TGCTGCTTCTCAGAGCTGCTG	0.602000													3	20					0	0	0.004672	0	0	
Unknown	0	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr16:32070612A>C	uc002ecv.1	+	1		c.65A>C								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:TRH1-22.																		GGTCTCCTGCAAGGCTTCTGG	0.552000													3	89					0	0	0.000248	0	0	
ABCC11	85320	broad.mit.edu	37	16	48201223	48201223	+	Missense_Mutation	SNP	C	T	T	rs139034695	by1000genomes	TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr16:48201223C>T	uc002eff.1	-	29	4461	c.4111G>A	c.(4111-4113)GCA>ACA	p.A1371T	ABCC11_uc002efg.1_Missense_Mutation_p.A1371T|ABCC11_uc002efh.1_Missense_Mutation_p.A1333T|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	1371	ABC transporter 2.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ATGAGGGCTGCGAACAATGAC	0.567000									Cerumen_Type				21	140					0	0	0.002299	0	0	
USP6	9098	broad.mit.edu	37	17	5038577	5038577	+	Silent	SNP	G	A	A	rs141506323	by1000genomes	TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr17:5038577G>A	uc002gau.1	+	16	2773	c.543G>A	c.(541-543)CCG>CCA	p.P181P	USP6_uc002gav.1_Silent_p.P181P|USP6_uc010ckz.1_5'UTR|uc002gba.2_5'Flank|uc002gbb.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	181	Rab-GAP TBC.				protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						AGTATAACCCGGTGAGTATTC	0.488000			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								22	113					0	0	0.003610	0	0	
Unknown	0	broad.mit.edu	37	17	25750994	25750994	+	RNA	SNP	G	C	C	rs117773564	by1000genomes	TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr17:25750994G>C	uc002gzg.2	+	8		c.1313G>C			uc002gzh.1_5'Flank|uc002gzi.1_5'Flank					Homo sapiens similar to ubiquitin specific protease 6, mRNA (cDNA clone IMAGE:5168266), with apparent retained intron.																		ACATCCTCCTGGCATATTCAG	0.433000													7	33					0	0	0.002450	0	0	
KIF2B	84643	broad.mit.edu	37	17	51900727	51900727	+	Silent	SNP	C	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr17:51900727C>T	uc002iua.2	+	1	489	c.333C>T	c.(331-333)ACC>ACT	p.T111T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	111					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						ACCAGCGTACCGCCACGAAAT	0.602000													33	117					0	0	0.004289	0	0	
C1QTNF1	114897	broad.mit.edu	37	17	77043955	77043955	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr17:77043955A>G	uc002jwp.2	+	4	971	c.631A>G	c.(631-633)ATC>GTC	p.I211V	C1QTNF1_uc002jwq.2_Missense_Mutation_p.I129V|C1QTNF1_uc002jwr.3_Missense_Mutation_p.I221V|C1QTNF1_uc002jws.2_Missense_Mutation_p.I211V|C1QTNF1_uc002jwt.2_Missense_Mutation_p.I309V	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	211	C1q.					collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			CTACCTGCACATCATGAAGAA	0.567000													21	101					0	0	0.002780	0	0	
BAIAP2	10458	broad.mit.edu	37	17	79077849	79077849	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr17:79077849C>T	uc002jzg.2	+	9	1115	c.1007C>T	c.(1006-1008)TCC>TTC	p.S336F	BAIAP2_uc002jyz.3_Missense_Mutation_p.S336F|BAIAP2_uc002jza.2_Missense_Mutation_p.S336F|BAIAP2_uc002jzc.2_Missense_Mutation_p.S336F|BAIAP2_uc002jzb.2_Missense_Mutation_p.S93F|BAIAP2_uc002jzd.2_Missense_Mutation_p.S336F|BAIAP2_uc002jzf.2_Missense_Mutation_p.S336F|BAIAP2_uc002jze.2_Missense_Mutation_p.S369F|BAIAP2_uc010wuh.1_Missense_Mutation_p.S258F|BAIAP2_uc002jzh.2_Missense_Mutation_p.S337F|BAIAP2_uc010wui.1_Missense_Mutation_p.S199F	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	336					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CTCAGCGACTCCTACTCCAAC	0.637000													21	103					0	0	0.001882	0	0	
EPB41L3	23136	broad.mit.edu	37	18	5398076	5398076	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr18:5398076G>A	uc002kmt.1	-	17	2502	c.2416C>T	c.(2416-2418)CGA>TGA	p.R806*	EPB41L3_uc010wzh.1_Nonsense_Mutation_p.R637*|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Nonsense_Mutation_p.R111*|EPB41L3_uc010wzf.1_Nonsense_Mutation_p.R103*|EPB41L3_uc010wzg.1_Nonsense_Mutation_p.R78*|EPB41L3_uc010dkr.2_Nonsense_Mutation_p.R198*	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	806	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GTTGGTTTTCGCGCAGACTCT	0.453000													79	251					0	0	0.003610	0	0	
ROCK1	6093	broad.mit.edu	37	18	18546911	18546911	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr18:18546911G>C	uc002kte.2	-	27	4260	c.3319C>G	c.(3319-3321)CCT>GCT	p.P1107A		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1107					actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TCAGCACTAGGAAAACTAGCA	0.378000													25	166					0	0	0.006320	0	0	
DCC	1630	broad.mit.edu	37	18	50734076	50734076	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr18:50734076A>G	uc002lfe.1	+	11	2337	c.1750A>G	c.(1750-1752)AAA>GAA	p.K584E	DCC_uc010xdr.1_Missense_Mutation_p.K432E|DCC_uc010dpf.1_Missense_Mutation_p.K239E	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	584	Extracellular (Potential).|Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ACTATCTTATAAACTGGAAGG	0.378000													6	70					0	0	0.004482	0	0	
PNPLA6	10908	broad.mit.edu	37	19	7624011	7624011	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr19:7624011G>A	uc010xjq.1	+	30	3898	c.3703G>A	c.(3703-3705)GAC>AAC	p.D1235N	PNPLA6_uc002mgq.1_Missense_Mutation_p.D1187N|PNPLA6_uc010xjp.1_Missense_Mutation_p.D1160N|PNPLA6_uc002mgr.1_Missense_Mutation_p.D1187N|PNPLA6_uc002mgs.2_Missense_Mutation_p.D1225N|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	1226	Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						CAAGACCATGGACTTTGGGAA	0.577000													9	45					0	0	0.008291	0	0	
BRD4	23476	broad.mit.edu	37	19	15379809	15379809	+	Silent	SNP	T	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr19:15379809T>A	uc002nar.2	-	3	552	c.330A>T	c.(328-330)ATA>ATT	p.I110I	BRD4_uc002nas.2_Silent_p.I110I|BRD4_uc002nat.3_Silent_p.I110I|BRD4_uc002nau.3_Silent_p.I110I	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	110	Bromo 1.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			AGCGCTTCTTTATTGTTCCCA	0.413000			T	NUT|C15orf55	lethal midline carcinoma of young people								14	121					0	0	0.004990	0	0	
DDA1	79016	broad.mit.edu	37	19	17424912	17424912	+	Silent	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr19:17424912G>A	uc002ngd.2	+	2	211	c.84G>A	c.(82-84)TCG>TCA	p.S28S	DDA1_uc002nge.2_5'UTR	NM_024050	NP_076955	Q9BW61	DDA1_HUMAN	DET1 and DDB1 associated 1	28										ovary(1)	1						GCAAAGCCTCGGTGAGTGCGT	0.542000													17	84					0	0	0.001882	0	0	
FGF21	26291	broad.mit.edu	37	19	49260235	49260235	+	Silent	SNP	C	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr19:49260235C>A	uc002pkn.1	+	3	860	c.288C>A	c.(286-288)GTC>GTA	p.V96V	FUT1_uc002pkk.2_5'Flank|FUT1_uc002pkm.1_5'Flank|FGF21_uc002pko.1_Silent_p.V96V	NM_019113	NP_061986	Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21 precursor	96					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TCTTGGGAGTCAAGACATCCA	0.567000													27	233					1.80694e-10	2.74472e-10	0.001786	1	0	
ZNF841	284371	broad.mit.edu	37	19	52569335	52569335	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr19:52569335A>C	uc002pyl.1	-	5	2004	c.1452T>G	c.(1450-1452)AAT>AAG	p.N484K	ZNF841_uc010ydh.1_Missense_Mutation_p.N600K|ZNF841_uc010epk.1_Intron	NM_001136499	NP_001129971	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	484	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCCACACACATTACATTTGT	0.428000													28	131					0	0	0.004656	0	0	
TRIB2	28951	broad.mit.edu	37	2	12858617	12858617	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr2:12858617G>A	uc002rbv.3	+	1	1620	c.184G>A	c.(184-186)GGG>AGG	p.G62R	TRIB2_uc010yjp.1_Intron	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	62	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TTCTTGTATCGGGAAATACTT	0.577000											OREG0014450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	83					0	0	0.004672	0	0	
ZNF513	130557	broad.mit.edu	37	2	27601052	27601052	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr2:27601052C>A	uc002rkk.2	-	4	1186	c.986G>T	c.(985-987)AGT>ATT	p.S329I	ZNF513_uc002rkj.2_Missense_Mutation_p.S267I	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	329					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCCAGCCGACTACCCTCACC	0.667000													11	35					4.3838e-07	6.41532e-07	0.001855	1	0	
LIMS1	3987	broad.mit.edu	37	2	109293101	109293101	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr2:109293101C>G	uc002teg.2	+	7	804	c.685C>G	c.(685-687)CAT>GAT	p.H229D	LIMS1_uc002tef.2_Missense_Mutation_p.H241D|LIMS1_uc002teh.2_Missense_Mutation_p.H229D|LIMS1_uc002tei.2_Missense_Mutation_p.H229D|LIMS1_uc002tej.2_Missense_Mutation_p.H266D|LIMS1_uc002tek.3_Missense_Mutation_p.H291D	NM_004987	NP_004978	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	229	LIM zinc-binding 4.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding				0						CTTTCTTGGACATCGCCATTA	0.348000													3	19					0	0	0.004672	0	0	
LRP2	4036	broad.mit.edu	37	2	170028593	170028593	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr2:170028593C>T	uc002ues.2	-	58	11408	c.11195G>A	c.(11194-11196)TGC>TAC	p.C3732Y		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3732	LDL-receptor class A 31.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AAGAGGGATGCAGTGGTGATT	0.458000													27	77					0	0	0.005443	0	0	
SP3	6670	broad.mit.edu	37	2	174820642	174820642	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr2:174820642C>A	uc002uig.2	-	4	762	c.598G>T	c.(598-600)GAA>TAA	p.E200*	SP3_uc002uie.2_Nonsense_Mutation_p.E132*|SP3_uc002uif.2_Nonsense_Mutation_p.E147*|SP3_uc010zel.1_Nonsense_Mutation_p.E197*	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	200	Transactivation domain (Gln-rich).				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TGACTGCTTTCTTGATTTATA	0.428000													32	416					6.50621e-10	9.75932e-10	0.002836	1	0	
C20orf85	128602	broad.mit.edu	37	20	56730598	56730598	+	Silent	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr20:56730598G>A	uc002xyv.2	+	3	263	c.225G>A	c.(223-225)CCG>CCA	p.P75P		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	75										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			GCATCCGGCCGGTGACCCCAG	0.438000													12	98					0	0	0.004007	0	0	
KRTAP11-1	337880	broad.mit.edu	37	21	32253653	32253653	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr21:32253653G>A	uc002yov.2	-	1	222	c.191C>T	c.(190-192)ACT>ATT	p.T64I		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	64						keratin filament	structural molecule activity			pancreas(1)	1						CTGGCAAGCAGTGGGCTCACA	0.562000													9	84					0	0	0.008291	0	0	
ATP2B2	491	broad.mit.edu	37	3	10401807	10401807	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr3:10401807G>T	uc003bvt.2	-	13	2099	c.1660C>A	c.(1660-1662)CCC>ACC	p.P554T	ATP2B2_uc003bvv.2_Missense_Mutation_p.P509T|ATP2B2_uc003bvw.2_Missense_Mutation_p.P509T|ATP2B2_uc010hdo.2_Missense_Mutation_p.P259T	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	554	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TTCTCTGGGGGCTGCAGAGAG	0.677000													7	42					0.00198382	0.00286817	0.001984	1	0	
GOLGA4	2803	broad.mit.edu	37	3	37370460	37370460	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr3:37370460C>G	uc003cgv.2	+	16	6372	c.6068C>G	c.(6067-6069)GCC>GGC	p.A2023G	GOLGA4_uc003cgw.2_Missense_Mutation_p.A2045G|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.A1904G	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	2023	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TTAGATAAGGCCCAGGAGGTG	0.328000													8	39					0	0	0.006214	0	0	
MYLK	4638	broad.mit.edu	37	3	123366073	123366073	+	Silent	SNP	C	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr3:123366073C>T	uc003ego.2	-	27	4899	c.4617G>A	c.(4615-4617)GAG>GAA	p.E1539E	MYLK_uc010hrr.2_Intron|MYLK_uc011bjv.1_Silent_p.E339E|MYLK_uc011bjw.1_Silent_p.E1539E|MYLK_uc003egp.2_Silent_p.E1470E|MYLK_uc003egq.2_Silent_p.E1539E|MYLK_uc003egr.2_Silent_p.E1470E|MYLK_uc003egs.2_Silent_p.E1363E	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1539	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCACTCACATCTCCAGGACCA	0.587000													9	40					0	0	0.008291	0	0	
TERT	7015	broad.mit.edu	37	5	1272312	1272312	+	Silent	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr5:1272312G>A	uc003jcb.1	-	7	2428	c.2370C>T	c.(2368-2370)GTC>GTT	p.V790V	TERT_uc003jbz.1_Intron|TERT_uc003jca.1_Silent_p.V778V|TERT_uc003jcc.1_Silent_p.V790V|TERT_uc003jcd.1_Intron|TERT_uc003jce.1_Intron	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	790	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCTCGATGACGACGGCATCCC	0.642000									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				5	26					0	0	0.001168	0	0	
JMY	133746	broad.mit.edu	37	5	78595999	78595999	+	Silent	SNP	A	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr5:78595999A>G	uc003kfx.3	+	5	2071	c.1551A>G	c.(1549-1551)ACA>ACG	p.T517T	JMY_uc003kfw.1_Silent_p.T163T	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	517	Interaction with p300/EP300 (By similarity).|Potential.				'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		GGGGTGGTACAGAAGCGATAG	0.348000													10	116					0	0	0.001855	0	0	
RASA1	5921	broad.mit.edu	37	5	86670727	86670727	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr5:86670727G>A	uc003kiw.2	+	15	2123	c.2005G>A	c.(2005-2007)GAT>AAT	p.D669N	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.D492N|RASA1_uc011ctv.1_Missense_Mutation_p.D502N|RASA1_uc011ctw.1_Missense_Mutation_p.D503N|RASA1_uc010jaw.2_Missense_Mutation_p.D491N	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	669	C2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CAAAGATCCTGATATCTGTAA	0.259000													10	56					0	0	0.008291	0	0	
P4HA2	8974	broad.mit.edu	37	5	131539839	131539839	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr5:131539839G>A	uc003kwh.2	-	9	1651	c.1087C>T	c.(1087-1089)CGA>TGA	p.R363*	P4HA2_uc003kwg.2_Nonsense_Mutation_p.R363*|P4HA2_uc003kwi.2_Nonsense_Mutation_p.R363*|P4HA2_uc003kwk.2_Nonsense_Mutation_p.R363*|P4HA2_uc003kwl.2_Nonsense_Mutation_p.R363*|P4HA2_uc003kwj.2_Nonsense_Mutation_p.R363*	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	363						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	ACGGTGGCTCGTGCAAGCTAG	0.502000													27	88					0	0	0.007291	0	0	
SCUBE3	222663	broad.mit.edu	37	6	35209384	35209384	+	Silent	SNP	C	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr6:35209384C>A	uc003okf.1	+	11	1266	c.1260C>A	c.(1258-1260)GGC>GGA	p.G420G	SCUBE3_uc003okg.1_Silent_p.G419G|SCUBE3_uc003okh.1_Silent_p.G307G	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	420					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						ACCGGTCTGGCAAGAAGGACA	0.582000											OREG0017372	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	122					2.47316e-13	3.80486e-13	0.003271	1	0	
ARMC2	84071	broad.mit.edu	37	6	109286202	109286202	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr6:109286202G>T	uc003pss.3	+	17	2479	c.2305G>T	c.(2305-2307)GAT>TAT	p.D769Y	ARMC2_uc011eao.1_Missense_Mutation_p.D604Y	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	769	ARM 12.						binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		CTGTTTAAGAGATTTGGGTCC	0.333000													51	238					2.44813e-32	3.81527e-32	0.003610	1	0	
LANCL2	55915	broad.mit.edu	37	7	55466150	55466150	+	Silent	SNP	C	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr7:55466150C>G	uc003tqp.2	+	3	935	c.357C>G	c.(355-357)GTC>GTG	p.V119V		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	119					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TGTACCGGGTCACATGTGACC	0.458000													3	115					0	0	0.000248	0	0	
HIP1	3092	broad.mit.edu	37	7	75186058	75186058	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr7:75186058G>A	uc003uds.1	-	17	1680	c.1639C>T	c.(1639-1641)CGG>TGG	p.R547W	HIP1_uc011kfz.1_Missense_Mutation_p.R424W	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	547	Potential.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						TGAAGCTCCCGTTGGCTTGTG	0.353000			T	PDGFRB	CMML								20	146					0	0	0.003954	0	0	
ZNF804B	219578	broad.mit.edu	37	7	88964359	88964359	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr7:88964359T>C	uc011khi.1	+	4	2601	c.2063T>C	c.(2062-2064)GTT>GCT	p.V688A		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	688						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ACCAGCAAGGTTTCCGGATGT	0.453000										HNSCC(36;0.09)			10	101					0	0	0.002450	0	0	
KIAA1429	25962	broad.mit.edu	37	8	95524295	95524295	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr8:95524295G>C	uc003ygo.1	-	12	2787	c.2774C>G	c.(2773-2775)CCA>CGA	p.P925R	KIAA1429_uc003ygp.2_Missense_Mutation_p.P925R|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	925					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			AACTCCTTCTGGGGTCATCAA	0.378000													5	38					0	0	0.000602	0	0	
LY6K	54742	broad.mit.edu	37	8	143784759	143784759	+	Silent	SNP	C	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr8:143784759C>T	uc011ljv.1	+	3	885	c.468C>T	c.(466-468)GCC>GCT	p.A156A	LY6K_uc011ljw.1_3'UTR|LY6K_uc011ljx.1_3'UTR	NM_017527	NP_059997	Q17RY6	LY6K_HUMAN	lymphocyte antigen 6 complex, locus K isoform 1	156						anchored to membrane|cytoplasm|extracellular region|nucleolus|plasma membrane				central_nervous_system(1)	1	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGCTGCTGGCCTCCATTGCAG	0.592000													5	22					0	0	0.001168	0	0	
KIAA1045	23349	broad.mit.edu	37	9	34976209	34976209	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr9:34976209C>T	uc003zvq.2	+	4	803	c.625C>T	c.(625-627)CGG>TGG	p.R209W	KIAA1045_uc003zvr.2_Missense_Mutation_p.R209W	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	209							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			GACCTTTCAGCGGTGTAAAGT	0.507000													13	66					0	0	0.003163	0	0	
DFNB31	25861	broad.mit.edu	37	9	117240980	117240980	+	Silent	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr9:117240980G>A	uc004biz.3	-	2	1339	c.690C>T	c.(688-690)ACC>ACT	p.T230T	DFNB31_uc004biy.3_5'UTR|DFNB31_uc004bja.3_Silent_p.T230T|DFNB31_uc004bjb.2_Silent_p.T230T	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	230					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						AGATGTGGTTGGTGACGTAGC	0.647000													4	20					0	0	0.001168	0	0	
FAM166A	401565	broad.mit.edu	37	9	140140109	140140109	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chr9:140140109A>T	uc004cmi.1	-	2	308	c.253T>A	c.(253-255)TAC>AAC	p.Y85N		NM_001001710	NP_001001710	Q6J272	F166A_HUMAN	hypothetical protein LOC401565	85										ovary(1)	1						TGGGGGATGTAGGGCTCCGTC	0.642000													28	51					0	0	0.002445	0	0	
CCDC22	28952	broad.mit.edu	37	X	49104740	49104740	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chrX:49104740C>T	uc004dnd.1	+	10	1337	c.1181C>T	c.(1180-1182)CCC>CTC	p.P394L	CCDC22_uc004dnc.1_RNA	NM_014008	NP_054727	O60826	CCD22_HUMAN	coiled-coil domain containing 22	394										central_nervous_system(1)	1						GAGCTGCTGCCCGATGGGACT	0.557000													7	17					0	0	0.001984	0	0	
GSPT2	23708	broad.mit.edu	37	X	51487601	51487601	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chrX:51487601T>G	uc004dpl.2	+	1	1105	c.879T>G	c.(877-879)AGT>AGG	p.S293R		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	293				S -> G (in Ref. 2; BAA91612).	cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					GCCACAAGAGTTTTGTCCCAA	0.443000													65	312					0	0	0.003610	0	0	
ELF4	2000	broad.mit.edu	37	X	129206276	129206276	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4301-01A-01D-1158-08	TCGA-CG-4301-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2aaa578-47b2-4cba-8014-39c1f310c0bf	7a4e827f-75e1-4b82-b8e1-cc7077849fba	g.chrX:129206276G>A	uc004evd.3	-	5	842	c.457C>T	c.(457-459)CAG>TAG	p.Q153*	ELF4_uc004eve.3_Nonsense_Mutation_p.Q153*	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	153	RUNX1-binding.				natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGCCCCTCCTGGTCACTAGTG	0.562000			T	ERG	AML								15	168					0	0	0.004007	0	0	
