Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
PRDM16	63976	broad.mit.edu	37	1	3328335	3328335	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:3328335G>A	uc001akf.2	+	9	1654	c.1574G>A	c.(1573-1575)CGG>CAG	p.R525Q	PRDM16_uc001akc.2_Missense_Mutation_p.R525Q|PRDM16_uc001akd.2_Missense_Mutation_p.R525Q|PRDM16_uc001ake.2_Missense_Mutation_p.R525Q|PRDM16_uc009vlh.2_Missense_Mutation_p.R226Q	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	525	Pro-rich.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TTGTACCCCCGGCCGCCTCTG	0.706000			T	EVI1	MDS|AML								12	146					0	0	0.001855	0	0	
PER3	8863	broad.mit.edu	37	1	7887365	7887365	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:7887365C>T	uc001aoo.2	+	17	2527	c.2352C>T	c.(2350-2352)ACC>ACT	p.T784T	PER3_uc009vmg.1_Silent_p.T792T|PER3_uc009vmh.1_Silent_p.T785T|PER3_uc001aop.2_Silent_p.T792T|PER3_uc010nzw.1_Silent_p.T473T	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	784	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CGAGCCCGACCTTCCCACCTG	0.701000													31	37					0	0	0.010818	0	0	
PTCHD2	57540	broad.mit.edu	37	1	11561886	11561886	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:11561886C>T	uc001ash.3	+	2	975	c.837C>T	c.(835-837)TTC>TTT	p.F279F	PTCHD2_uc001asi.1_Silent_p.F279F	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	279	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AGCTCATCTTCCTGGCGCGCG	0.657000													15	18					0	0	0.004990	0	0	
RNF220	55182	broad.mit.edu	37	1	44878323	44878323	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:44878323A>C	uc001clv.1	+	2	914	c.554A>C	c.(553-555)AAG>ACG	p.K185T	RNF220_uc001clw.1_Missense_Mutation_p.K185T	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	185					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						ACTGGGAAGAAGATTTTTGCT	0.498000													7	72					0	0	0.003080	0	0	
CYP4B1	1580	broad.mit.edu	37	1	47276838	47276838	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:47276838T>G	uc001cqm.3	+	3	433	c.349T>G	c.(349-351)TTC>GTC	p.F117V	CYP4B1_uc009vyl.1_Intron|CYP4B1_uc001cqn.3_Missense_Mutation_p.F117V|CYP4B1_uc009vym.2_Intron|CYP4B1_uc010omk.1_Intron|CYP4B1_uc010oml.1_5'UTR	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	117					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TGTGTATGACTTCTTCCTCCA	0.582000													3	64					0	0	0.000602	0	0	
DAB1	1600	broad.mit.edu	37	1	57537289	57537289	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:57537289C>T	uc001cys.1	-	8	1138	c.464G>A	c.(463-465)AGA>AAA	p.R155K	DAB1_uc001cyt.1_Missense_Mutation_p.R155K|DAB1_uc001cyq.1_Missense_Mutation_p.R155K|DAB1_uc001cyr.1_Intron|DAB1_uc009vzw.1_Missense_Mutation_p.R155K|DAB1_uc009vzx.1_Missense_Mutation_p.R155K	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	155	PID.				cell differentiation|nervous system development					skin(2)|ovary(1)	3						AAAGAGATCTCTCAAGTCCAG	0.398000													8	26					0	0	0.006214	0	0	
NFIA	4774	broad.mit.edu	37	1	61872278	61872278	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:61872278C>T	uc001czw.2	+	9	1783	c.1299C>T	c.(1297-1299)CCC>CCT	p.P433P	NFIA_uc001czy.2_Silent_p.P425P|NFIA_uc010oos.1_Silent_p.P478P|NFIA_uc001czv.2_Silent_p.P433P|NFIA_uc001czx.2_Silent_p.P81P|NFIA_uc009wae.2_RNA	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	433					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						CATTCCTTCCCACCCCAATGT	0.602000													3	28					0	0	0.004672	0	0	
INADL	10207	broad.mit.edu	37	1	62271131	62271131	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:62271131G>C	uc001dab.2	+	13	1675	c.1561G>C	c.(1561-1563)GAC>CAC	p.D521H	INADL_uc009waf.1_Missense_Mutation_p.D521H|INADL_uc001daa.2_Missense_Mutation_p.D521H|INADL_uc001dad.3_Missense_Mutation_p.D218H|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	521					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AAAAGTCCCAGACTCTCCAGA	0.353000													22	39					0	0	0.002780	0	0	
DIRAS3	9077	broad.mit.edu	37	1	68512611	68512611	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:68512611G>A	uc001ded.2	-	2	665	c.370C>T	c.(370-372)CTG>TTG	p.L124L	uc001deb.1_Intron|uc001dec.1_Intron	NM_004675	NP_004666	O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	124					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						AGCTCTTCCAGGGTTTCCTTC	0.552000													13	190					0	0	0.002450	0	0	
TTLL7	79739	broad.mit.edu	37	1	84369788	84369788	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:84369788T>G	uc001djc.2	-	18	2578	c.2182A>C	c.(2182-2184)AAA>CAA	p.K728Q	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	728					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		GAGTCCAATTTTATGAGCCAA	0.333000													20	46					0	0	0.002780	0	0	
SLC44A3	126969	broad.mit.edu	37	1	95303425	95303425	+	Nonsense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:95303425T>G	uc001dqv.3	+	6	775	c.668T>G	c.(667-669)TTA>TGA	p.L223*	SLC44A3_uc001dqx.3_Nonsense_Mutation_p.L223*|SLC44A3_uc010otq.1_Nonsense_Mutation_p.L155*|SLC44A3_uc010otr.1_Nonsense_Mutation_p.L187*|SLC44A3_uc001dqw.3_Nonsense_Mutation_p.L175*|SLC44A3_uc010ots.1_Nonsense_Mutation_p.L143*|SLC44A3_uc009wds.2_Nonsense_Mutation_p.L126*|SLC44A3_uc010ott.1_Nonsense_Mutation_p.L143*|SLC44A3_uc010otu.1_RNA	NM_001114106	NP_001107578	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3 isoform 1	223	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)	1		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	ATCCTCGCATTAGGTAATTCT	0.348000													7	75					0	0	0.001984	0	0	
FNDC7	163479	broad.mit.edu	37	1	109270515	109270515	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:109270515A>G	uc001dvx.2	+	7	1197	c.1197A>G	c.(1195-1197)GAA>GAG	p.E399E	FNDC7_uc010ova.1_Silent_p.E166E	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	400	Fibronectin type-III 5.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GTGGTGCCGAACTGTATGAAA	0.512000													12	87					0	0	0.010729	0	0	
PRUNE	58497	broad.mit.edu	37	1	151006649	151006649	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:151006649T>A	uc001ewh.1	+	8	1437	c.1301T>A	c.(1300-1302)TTC>TAC	p.F434Y	PRUNE_uc001ewi.1_Missense_Mutation_p.F252Y|PRUNE_uc010pco.1_Missense_Mutation_p.F202Y|PRUNE_uc001ewj.1_Missense_Mutation_p.F149Y|PRUNE_uc001ewk.1_Missense_Mutation_p.F199Y|BNIPL_uc009wmi.2_5'Flank|BNIPL_uc001ewl.2_5'Flank	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	434						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGGCCGTCTTCGAGAAGTGC	0.582000													82	102					0	0	0.014410	0	0	
POGZ	23126	broad.mit.edu	37	1	151380596	151380596	+	Silent	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:151380596A>C	uc001eyd.1	-	15	2661	c.2355T>G	c.(2353-2355)GCT>GCG	p.A785A	POGZ_uc001eye.1_Silent_p.A732A|POGZ_uc010pdb.1_Silent_p.A776A|POGZ_uc001eyf.1_Silent_p.A741A|POGZ_uc010pdc.1_Silent_p.A723A|POGZ_uc009wmv.1_Silent_p.A690A|POGZ_uc010pdd.1_Silent_p.A276A	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	785	C2H2-type 8.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGTTGGCATAAGCTCGAGAAC	0.393000													10	69					0	0	0.006214	0	0	
TCHHL1	126637	broad.mit.edu	37	1	152059360	152059360	+	Silent	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:152059360T>C	uc001ezo.1	-	3	863	c.798A>G	c.(796-798)AAA>AAG	p.K266K		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	266							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GTGTTGCTTCTTTTGGTGGTG	0.428000													22	208					0	0	0.003330	0	0	
FLG	2312	broad.mit.edu	37	1	152280800	152280800	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:152280800T>G	uc001ezu.1	-	3	6598	c.6562A>C	c.(6562-6564)AGT>CGT	p.S2188R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2188	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCTTGCACTTCTGGATCCT	0.532000									Ichthyosis				104	424					0	0	0.014410	0	0	
FLG2	388698	broad.mit.edu	37	1	152329336	152329336	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:152329336T>C	uc001ezw.3	-	3	999	c.926A>G	c.(925-927)CAA>CGA	p.Q309R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	309	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATAGCTAAATTGATTTCCTTG	0.473000													24	177					0	0	0.003330	0	0	
HSPA7	3311	broad.mit.edu	37	1	161576616	161576616	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:161576616C>T	uc010pkp.1	+	1	768	c.536C>T	c.(535-537)ACG>ATG	p.T179M		NR_024151				RecName: Full=Putative heat shock 70 kDa protein 7; AltName: Full=Heat shock 70 kDa protein B;												0						AATGAGGCCACGGCAGCAGCC	0.642000													8	42					0	0	0.008291	0	0	
LMX1A	4009	broad.mit.edu	37	1	165218827	165218827	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:165218827T>G	uc001gcy.1	-	3	535	c.314A>C	c.(313-315)GAG>GCG	p.E105A	LMX1A_uc001gcz.1_Missense_Mutation_p.E105A	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	105	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CATAACAAACTCATTGGGAGC	0.522000													6	26					0	0	0.001168	0	0	
TADA1	117143	broad.mit.edu	37	1	166831580	166831580	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:166831580C>T	uc001gdw.2	-	5	584	c.400G>A	c.(400-402)GAC>AAC	p.D134N	TADA1_uc001gdv.2_5'UTR	NM_053053	NP_444281	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1-like	134					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(1)	1						TTCAAGTCGTCATCATCTTGG	0.438000													4	58					0	0	0.009096	0	0	
SLC9A11	284525	broad.mit.edu	37	1	173517591	173517591	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:173517591T>G	uc001giz.2	-	12	1821	c.1398A>C	c.(1396-1398)GAA>GAC	p.E466D	SLC9A11_uc009wwe.2_Missense_Mutation_p.E24D|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	466					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TCAAAATTTTTTCTGTTTTAA	0.353000													19	34					0	0	0.012319	0	0	
C1orf27	54953	broad.mit.edu	37	1	186375301	186375301	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:186375301G>A	uc001grw.2	+	13	1323	c.1087G>A	c.(1087-1089)GAC>AAC	p.D363N	C1orf27_uc010poq.1_Missense_Mutation_p.D340N|C1orf27_uc010por.1_Missense_Mutation_p.D331N	NM_017847	NP_060317	Q5SWX8	ODR4_HUMAN	odorant response abnormal 4 isoform 1	363						integral to membrane	oxidoreductase activity|zinc ion binding			ovary(1)	1						TTATAAATTTGACGATGAGTC	0.388000													35	98					0	0	0.004878	0	0	
FAM58B	339521	broad.mit.edu	37	1	200182938	200182938	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:200182938T>G	uc009wzi.1	+	1	283	c.247T>G	c.(247-249)TTG>GTG	p.L83V		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	83					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					TTCCATTTACTTGGCCGGCAA	0.527000													23	176					0	0	0.002780	0	0	
CHIT1	1118	broad.mit.edu	37	1	203188382	203188382	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:203188382A>C	uc001gzn.2	-	9	1087	c.991T>G	c.(991-993)TGG>GGG	p.W331G	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_Missense_Mutation_p.W122G|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.W322G	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	331					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						AAGCCCACCCACTGGTTGTCC	0.567000													58	96					0	0	0.014410	0	0	
USH2A	7399	broad.mit.edu	37	1	216420388	216420388	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:216420388T>A	uc001hku.1	-	13	2735	c.2348A>T	c.(2347-2349)AAC>ATC	p.N783I	USH2A_uc001hkv.2_Missense_Mutation_p.N783I	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	783	Laminin EGF-like 5.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCCATAAAAGTTTTCTCTGCA	0.483000										HNSCC(13;0.011)			31	64					0	0	0.008361	0	0	
RYR2	6262	broad.mit.edu	37	1	237813289	237813289	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:237813289C>T	uc001hyl.1	+	50	7745	c.7625C>T	c.(7624-7626)GCT>GTT	p.A2542V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2542	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGCACCACGCTTCTCTCATT	0.468000													49	99					0	0	0.014410	0	0	
AKT3	10000	broad.mit.edu	37	1	243858949	243858949	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:243858949T>A	uc001iab.1	-	2	197	c.116A>T	c.(115-117)AAA>ATA	p.K39I	AKT3_uc001hzz.1_Missense_Mutation_p.K39I	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	39	PH.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			AGGTTTCTCTTTATATCCTAT	0.338000													9	22					0	0	0.004482	0	0	
AKT3	10000	broad.mit.edu	37	1	243858952	243858952	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:243858952T>A	uc001iab.1	-	2	194	c.113A>T	c.(112-114)TAT>TTT	p.Y38F	AKT3_uc001hzz.1_Missense_Mutation_p.Y38F	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	38	PH.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			TTTCTCTTTATATCCTATGAA	0.338000													10	21					0	0	0.006214	0	0	
OR2G6	391211	broad.mit.edu	37	1	248685027	248685027	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr1:248685027T>G	uc001ien.1	+	1	80	c.80T>G	c.(79-81)CTT>CGT	p.L27R		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAGAGGTTTCTTTTTGCCATC	0.458000													33	78					0	0	0.005524	0	0	
ITGA8	8516	broad.mit.edu	37	10	15650283	15650283	+	Silent	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:15650283A>C	uc001ioc.1	-	16	1560	c.1560T>G	c.(1558-1560)TCT>TCG	p.S520S	ITGA8_uc010qcb.1_Silent_p.S505S	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	520	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ATACTCTTAAAGAAAAGCTAT	0.308000													14	62					0	0	0.004990	0	0	
VIM	7431	broad.mit.edu	37	10	17277380	17277380	+	Missense_Mutation	SNP	G	T	T	rs150986868		TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:17277380G>T	uc001iou.2	+	7	1634	c.1221G>T	c.(1219-1221)GAG>GAT	p.E407D	VIM_uc001iov.1_Missense_Mutation_p.E407D|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Missense_Mutation_p.E407D|VIM_uc001ioy.1_Intron|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Missense_Mutation_p.E365D|VIM_uc001ipc.1_Missense_Mutation_p.E407D	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	407	Rod.|Coil 2.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton	p.E407K(1)		large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						TGGAAGGCGAGGAGAGCAGGT	0.368000													7	32					0.00198382	0.00203557	0.001984	1	0	
LYZL1	84569	broad.mit.edu	37	10	29599960	29599960	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:29599960A>C	uc001iul.2	+	5	614	c.557A>C	c.(556-558)GAG>GCG	p.E186A		NM_032517	NP_115906	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	140					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Breast(68;0.203)				GACCTGTCCGAGTGGAAAAAA	0.507000													61	53					0	0	0.014410	0	0	
ZEB1	6935	broad.mit.edu	37	10	31810825	31810825	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:31810825A>G	uc001ivs.3	+	7	2625	c.2562A>G	c.(2560-2562)CAA>CAG	p.Q854Q	ZEB1_uc001ivr.3_Silent_p.Q636Q|ZEB1_uc010qee.1_Silent_p.Q636Q|ZEB1_uc010qef.1_Silent_p.Q636Q|ZEB1_uc009xlj.1_Silent_p.Q780Q|ZEB1_uc010qeg.1_Silent_p.Q713Q|ZEB1_uc009xlk.1_Silent_p.Q636Q|ZEB1_uc001ivt.3_Silent_p.Q636Q|ZEB1_uc001ivu.3_Silent_p.Q855Q|ZEB1_uc001ivv.3_Silent_p.Q834Q|ZEB1_uc010qeh.1_Silent_p.Q787Q|ZEB1_uc009xlo.1_Silent_p.Q837Q|ZEB1_uc009xlp.2_Silent_p.Q838Q	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	854					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				CTGCAGTCCAAGAACCACCCT	0.438000													22	170					0	0	0.012319	0	0	
LRRC18	474354	broad.mit.edu	37	10	50122031	50122031	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:50122031A>C	uc001jhd.2	-	1	250	c.170T>G	c.(169-171)CTT>CGT	p.L57R	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Missense_Mutation_p.L57R	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	57	LRR 2.					cytoplasm				ovary(1)|pancreas(1)	2						ATTCCGGCTAAGGTCCAGCTC	0.507000													4	77					0	0	0.009096	0	0	
AGAP7	653268	broad.mit.edu	37	10	51465608	51465608	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:51465608G>A	uc001jio.2	-	7	974	c.848C>T	c.(847-849)ACC>ATC	p.T283I	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron	NM_001077685	NP_001071153	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	283	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						GGAACACAGGGTGACGTATTT	0.428000													141	186					0	0	0.014410	0	0	
DKK1	22943	broad.mit.edu	37	10	54074383	54074383	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:54074383G>A	uc001jjr.2	+	1	343	c.189G>A	c.(187-189)GCG>GCA	p.A63A	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	63					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TCAGCGCCGCGCCGGGAATCC	0.622000											OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	61					0	0	0.006214	0	0	
FAM13C	220965	broad.mit.edu	37	10	61112135	61112135	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:61112135G>A	uc001jkn.2	-	4	353	c.219C>T	c.(217-219)ACC>ACT	p.T73T	FAM13C_uc001jko.2_Silent_p.T73T|FAM13C_uc010qid.1_5'UTR|FAM13C_uc010qie.1_5'UTR|FAM13C_uc010qif.1_Silent_p.T95T|FAM13C_uc001jkp.2_5'UTR	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	73										ovary(2)	2						CCACCAGCACGGTCGCCTCTA	0.582000													28	33					0	0	0.007291	0	0	
UNC5B	219699	broad.mit.edu	37	10	73051239	73051239	+	Missense_Mutation	SNP	G	A	A	rs141795100	byFrequency	TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:73051239G>A	uc001jro.2	+	10	1790	c.1345G>A	c.(1345-1347)GCC>ACC	p.A449T	UNC5B_uc001jrp.2_Missense_Mutation_p.A438T	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	449	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						GACAGCCAGCGCCGGCATCTA	0.617000													39	21					0	0	0.007835	0	0	
TTC18	118491	broad.mit.edu	37	10	75056898	75056898	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:75056898A>T	uc009xrc.2	-	16	1877	c.1756T>A	c.(1756-1758)TTG>ATG	p.L586M	TTC18_uc001jty.2_Missense_Mutation_p.L586M|TTC18_uc009xrd.1_Missense_Mutation_p.L400M|TTC18_uc001jtx.2_Translation_Start_Site	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	586							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					GTTGTCTTCAAGTATTTATCT	0.438000													5	91					0	0	0.001984	0	0	
ABCC2	1244	broad.mit.edu	37	10	101595995	101595995	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:101595995G>A	uc001kqf.2	+	25	3701	c.3562G>A	c.(3562-3564)GTG>ATG	p.V1188M		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	1188	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACACAATGAGGTGAGGATTGA	0.498000													6	66					0	0	0.003080	0	0	
LDB1	8861	broad.mit.edu	37	10	103870449	103870449	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:103870449C>T	uc009xwz.2	-	6	705	c.362G>A	c.(361-363)CGG>CAG	p.R121Q	LDB1_uc001kuk.3_Missense_Mutation_p.R85Q|LDB1_uc001kul.3_Missense_Mutation_p.R85Q	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	121					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		GATCAGGGTCCGGCCAATGGC	0.552000													15	15					0	0	0.008871	0	0	
FAM45A	404636	broad.mit.edu	37	10	120896041	120896041	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:120896041C>T	uc001ldw.2	+	9	1000	c.956C>T	c.(955-957)TCG>TTG	p.S319L	FAM45A_uc010qsv.1_Missense_Mutation_p.S311L|FAM45A_uc010qsw.1_Missense_Mutation_p.S168L|FAM45A_uc010qsx.1_RNA|FAM45A_uc010qsy.1_Missense_Mutation_p.S246L|FAM45A_uc010qsz.1_Missense_Mutation_p.S208L	NM_207009	NP_996892	Q8TCE6	FA45A_HUMAN	hypothetical protein LOC404636	319										ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		TCAGAAGTTTCGGCTGATGGA	0.388000													30	38					0	0	0.009718	0	0	
LHPP	64077	broad.mit.edu	37	10	126301905	126301905	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:126301905G>A	uc001lhs.1	+	7	809	c.789G>A	c.(787-789)CTG>CTA	p.L263L	LHPP_uc001lht.1_3'UTR|LHPP_uc009yai.1_Silent_p.L180L|LHPP_uc009yaj.1_RNA	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	263					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		CAGTGGACCTGCTGCTGCAGC	0.438000													33	64					0	0	0.004289	0	0	
SYCE1	93426	broad.mit.edu	37	10	135372434	135372434	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr10:135372434T>C	uc001lno.2	-	4	323	c.218A>G	c.(217-219)GAC>GGC	p.D73G	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_5'UTR|SYCE1_uc009ybn.2_Missense_Mutation_p.D73G|SYCE1_uc001lnn.2_Missense_Mutation_p.D37G	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	73	Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CTCTCCTAGGTCTTTATTGGC	0.512000													3	27					0	0	0.004672	0	0	
MUC6	4588	broad.mit.edu	37	11	1017413	1017413	+	Silent	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:1017413G>T	uc001lsw.2	-	31	5439	c.5388C>A	c.(5386-5388)CCC>CCA	p.P1796P		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1796	Thr-rich.|2.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTGTGGTGAAGGGTGTGGGTA	0.592000													30	595					6.45866e-13	6.94416e-13	0.008740	1	0	
OR51B2	79345	broad.mit.edu	37	11	5344612	5344612	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:5344612A>G	uc001mao.1	-	1	971	c.916T>C	c.(916-918)TCT>CCT	p.S306P	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTATGTTTAGATAAAAGGCGG	0.363000													15	22					0	0	0.003163	0	0	
OR56B1	387748	broad.mit.edu	37	11	5757774	5757774	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:5757774A>G	uc001mbt.1	+	1	28	c.28A>G	c.(28-30)ATC>GTC	p.I10V	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|OR56B1_uc001mbs.1_Missense_Mutation_p.I10V|OR56B1_uc009yev.1_Missense_Mutation_p.I10V	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		ATCTCTCAAAATCTCCAATAG	0.433000													22	37					0	0	0.010504	0	0	
OR52N1	79473	broad.mit.edu	37	11	5809861	5809861	+	Nonsense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:5809861A>T	uc010qzo.1	-	1	186	c.186T>A	c.(184-186)TAT>TAA	p.Y62*	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		CAAGGAAGACATACATAGGTC	0.453000													29	40					0	0	0.005443	0	0	
APBB1	322	broad.mit.edu	37	11	6416828	6416828	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:6416828C>T	uc001mdb.1	-	14	2169	c.2069G>A	c.(2068-2070)CGC>CAC	p.R690H	APBB1_uc001mcz.1_Missense_Mutation_p.R309H|APBB1_uc001mdd.3_Missense_Mutation_p.R468H|APBB1_uc001mda.2_Missense_Mutation_p.R215H|APBB1_uc001mdc.1_Missense_Mutation_p.R688H|APBB1_uc001mcy.1_3'UTR	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	690	PID 2.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		AACACCCCTGCGGACAGTCCA	0.652000													12	14					0	0	0.002450	0	0	
NLRP14	338323	broad.mit.edu	37	11	7060049	7060049	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:7060049A>C	uc001mfb.1	+	2	555	c.232A>C	c.(232-234)ATC>CTC	p.I78L		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	78	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GTCTCTCAAAATCTTTGGCAA	0.493000													4	44					0	0	0.009096	0	0	
GALNTL4	374378	broad.mit.edu	37	11	11394149	11394149	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:11394149A>G	uc001mjo.2	-	6	1426	c.1005T>C	c.(1003-1005)ATT>ATC	p.I335I		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	335	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		GCCGGTCCACAATGAAGCAGC	0.602000													13	18					0	0	0.002450	0	0	
ANO5	203859	broad.mit.edu	37	11	22248854	22248854	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:22248854G>A	uc001mqi.2	+	7	687	c.370G>A	c.(370-372)GAA>AAA	p.E124K	ANO5_uc001mqj.2_Missense_Mutation_p.E123K	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	124	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						GCAGGACTCGGAAGATGGAAG	0.353000													15	92					0	0	0.004990	0	0	
SLC17A6	57084	broad.mit.edu	37	11	22381048	22381048	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:22381048T>G	uc001mqk.2	+	4	961	c.548T>G	c.(547-549)GTC>GGC	p.V183G		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	183	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						GTCATCTTTGTCAGAATACTG	0.408000													10	40					0	0	0.008291	0	0	
GAS2	2620	broad.mit.edu	37	11	22833429	22833429	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:22833429G>A	uc009yie.2	+	8	1115	c.809G>A	c.(808-810)CGA>CAA	p.R270Q	GAS2_uc001mqm.2_Missense_Mutation_p.R270Q|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.R270Q	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	270	GAR.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						GACCCCTGCCGAATGCTGCAG	0.463000													12	51					0	0	0.010729	0	0	
ANO3	63982	broad.mit.edu	37	11	26620487	26620487	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:26620487A>G	uc001mqt.3	+	16	1758	c.1613A>G	c.(1612-1614)CAG>CGG	p.Q538R	ANO3_uc010rdr.1_Missense_Mutation_p.Q522R|ANO3_uc010rds.1_Missense_Mutation_p.Q377R|ANO3_uc010rdt.1_Missense_Mutation_p.Q392R	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	538	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GAACCACATCAGCCTTCCTCA	0.403000													3	48					0	0	0.004672	0	0	
OR4C13	283092	broad.mit.edu	37	11	49974148	49974148	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:49974148C>A	uc010rhz.1	+	1	174	c.174C>A	c.(172-174)TAC>TAA	p.Y58*		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						CCCCCATGTACTTTTTCCTGG	0.423000													40	172					9.9998e-32	1.10278e-31	0.011902	1	0	
OR4A5	81318	broad.mit.edu	37	11	51412114	51412114	+	Silent	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:51412114A>C	uc001nhi.1	-	1	282	c.282T>G	c.(280-282)GGT>GGG	p.G94G		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GGCCCATGCAACCTTGGAAGG	0.448000													18	30					0	0	0.004990	0	0	
OR5M8	219484	broad.mit.edu	37	11	56258219	56258219	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:56258219G>C	uc001nix.1	-	1	628	c.628C>G	c.(628-630)CTC>GTC	p.L210V		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					ATGATGAAGAGAGAAAAAGAA	0.433000													31	28					0	0	0.009535	0	0	
APLNR	187	broad.mit.edu	37	11	57004241	57004241	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:57004241C>A	uc001njo.2	-	1	687	c.238G>T	c.(238-240)GTG>TTG	p.V80L	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	80	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						GGCAGCGTCACCACGAAGGTC	0.587000													18	21					5.03518e-11	5.32871e-11	0.007413	1	0	
SYTL2	54843	broad.mit.edu	37	11	85445318	85445318	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:85445318G>A	uc010rth.1	-	6	1327	c.1051C>T	c.(1051-1053)CGG>TGG	p.R351W	SYTL2_uc010rtg.1_Missense_Mutation_p.R352W|SYTL2_uc010rti.1_Missense_Mutation_p.R351W|SYTL2_uc010rtj.1_Missense_Mutation_p.R303W|SYTL2_uc001pbf.3_Missense_Mutation_p.R351W|SYTL2_uc010rtf.1_Missense_Mutation_p.R209W	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	351					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CCTACTTCCCGACCATGGATT	0.458000													10	153					0	0	0.006214	0	0	
FAT3	120114	broad.mit.edu	37	11	92531644	92531644	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:92531644A>C	uc001pdj.3	+	9	5482	c.5465A>C	c.(5464-5466)AAG>ACG	p.K1822T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1822	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACAGCAAAAAAGTTTTTCACG	0.473000										TCGA Ovarian(4;0.039)			4	37					0	0	0.009096	0	0	
DYNC2H1	79659	broad.mit.edu	37	11	103175338	103175338	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:103175338A>C	uc001pho.2	+	77	11415	c.11271A>C	c.(11269-11271)CAA>CAC	p.Q3757H	DYNC2H1_uc001phn.1_Missense_Mutation_p.Q3764H|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3757	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CCATGGGTCAAGGTCAAGCTG	0.358000													9	55					0	0	0.004482	0	0	
CASP1	834	broad.mit.edu	37	11	104900547	104900547	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:104900547G>A	uc010rve.1	-	6	724	c.707C>T	c.(706-708)TCT>TTT	p.S236F	CASP1_uc001pig.2_Missense_Mutation_p.S143F|CASP1_uc001pik.2_Missense_Mutation_p.S199F|CASP1_uc010rvf.1_Missense_Mutation_p.S143F|CASP1_uc010rvg.1_Missense_Mutation_p.S215F|CASP1_uc010rvh.1_Missense_Mutation_p.S143F|CASP1_uc010rvi.1_Intron|CASP1_uc001pim.3_Missense_Mutation_p.S236F|CASP1_uc009yxi.2_Missense_Mutation_p.S215F|CASP1_uc010rvj.1_Missense_Mutation_p.S236F|CASP1_uc009yxj.2_Missense_Mutation_p.S81F|CASP1_uc010rvk.1_Missense_Mutation_p.S197F	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	236					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	AATACCATGAGACATGAACAC	0.463000													19	198					0	0	0.012319	0	0	
KIAA1826	84437	broad.mit.edu	37	11	105881326	105881326	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:105881326G>C	uc001piy.2	-	2	492	c.319C>G	c.(319-321)CTC>GTC	p.L107V	KIAA1826_uc001piz.2_Missense_Mutation_p.L107V	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	107						nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		TCTTCAGTGAGAGAGTCATCC	0.443000													18	81					0	0	0.004990	0	0	
CUL5	8065	broad.mit.edu	37	11	107925631	107925631	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:107925631A>T	uc001pjv.2	+	7	1396	c.729A>T	c.(727-729)AAA>AAT	p.K243N	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	243					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		AAGAAGAAAAACGAGCACTAC	0.313000													13	32					0	0	0.002450	0	0	
EXPH5	23086	broad.mit.edu	37	11	108380425	108380425	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:108380425T>C	uc001pkk.2	-	6	5920	c.5809A>G	c.(5809-5811)AGC>GGC	p.S1937G	EXPH5_uc010rvy.1_Missense_Mutation_p.S1749G|EXPH5_uc010rvz.1_Missense_Mutation_p.S1781G|EXPH5_uc010rwa.1_Missense_Mutation_p.S1861G	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1937					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GAATTTGAGCTTAATGACTCT	0.438000													30	55					0	0	0.006320	0	0	
ALG9	79796	broad.mit.edu	37	11	111724443	111724443	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:111724443C>T	uc001pmb.2	-	8	817	c.718G>A	c.(718-720)GAT>AAT	p.D240N	ALG9_uc001ply.2_Missense_Mutation_p.D69N|ALG9_uc001plz.2_Missense_Mutation_p.D69N|ALG9_uc010rwm.1_Missense_Mutation_p.D240N|ALG9_uc010rwn.1_Missense_Mutation_p.D194N|ALG9_uc010rwo.1_Missense_Mutation_p.D68N|ALG9_uc009yyh.1_Missense_Mutation_p.D135N	NM_001077690	NP_001071158	Q9H6U8	ALG9_HUMAN	asparagine-linked glycosylation 9 protein	240	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			large_intestine(1)|ovary(1)	2		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		ACCAGCAAATCAAAGGCAATG	0.398000													22	120					0	0	0.014323	0	0	
CADM1	23705	broad.mit.edu	37	11	115109343	115109343	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:115109343T>G	uc001ppi.3	-	3	430	c.301A>C	c.(301-303)AAT>CAT	p.N101H	CADM1_uc001ppf.3_Missense_Mutation_p.N101H|CADM1_uc001ppk.3_Missense_Mutation_p.N101H|CADM1_uc001ppj.3_Missense_Mutation_p.N101H|CADM1_uc001ppl.2_Missense_Mutation_p.N101H	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	101	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		CTAGAAAAATTCAGCAACTGA	0.393000													4	61					0	0	0.009096	0	0	
AMICA1	120425	broad.mit.edu	37	11	118083275	118083275	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:118083275A>G	uc001psk.2	-	3	219	c.45T>C	c.(43-45)GAT>GAC	p.D15D	AMICA1_uc001psh.2_5'UTR|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Silent_p.D5D|AMICA1_uc001psj.2_Silent_p.D15D|AMICA1_uc010rxw.1_5'UTR|AMICA1_uc010rxx.1_Silent_p.D15D|AMICA1_uc001psl.1_Intron	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	15					blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCAAGGAATAATCTATAGAAG	0.438000													8	41					0	0	0.004482	0	0	
MLL	4297	broad.mit.edu	37	11	118375019	118375019	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:118375019C>T	uc001pta.2	+	27	8426	c.8403C>T	c.(8401-8403)CTC>CTT	p.L2801L	MLL_uc001ptb.2_Silent_p.L2804L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2801					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AAGCTCAGCTCAGCTCATTGG	0.448000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								5	139					0	0	0.001168	0	0	
POU2F3	25833	broad.mit.edu	37	11	120169080	120169080	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:120169080T>A	uc001pxc.2	+	4	341	c.239T>A	c.(238-240)CTA>CAA	p.L80Q	POU2F3_uc010rzk.1_Silent_p.A18A|POU2F3_uc010rzl.1_Missense_Mutation_p.L10Q	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	80					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		ATGTCTGGGCTAAATGCCAGC	0.527000													9	207					0	0	0.004482	0	0	
C11orf63	79864	broad.mit.edu	37	11	122817501	122817501	+	Splice_Site	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:122817501G>C	uc001pym.2	+	6	2226	c.1929_splice	c.e6+1	p.K643_splice		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1											ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		CAGCAGTAAGGTAATAAAAGC	0.378000													13	53					0	0	0.001855	0	0	
OR4D5	219875	broad.mit.edu	37	11	123811129	123811129	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:123811129A>C	uc001pzk.1	+	1	806	c.806A>C	c.(805-807)AAG>ACG	p.K269T		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCCATGGACAAGGCCGTCTCT	0.498000													6	145					0	0	0.001168	0	0	
OR8B2	26595	broad.mit.edu	37	11	124252930	124252930	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:124252930A>C	uc010sai.1	-	1	310	c.310T>G	c.(310-312)TTT>GTT	p.F104V		NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AAAAAGAGAAAGAAAAACAGC	0.388000													13	64					0	0	0.002450	0	0	
OR8B4	283162	broad.mit.edu	37	11	124294715	124294715	+	Nonsense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr11:124294715G>C	uc010sak.1	-	1	53	c.53C>G	c.(52-54)TCA>TGA	p.S18*		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGGCTGTTCTGATAATCCCAC	0.478000													12	65					0	0	0.013537	0	0	
B4GALNT3	283358	broad.mit.edu	37	12	657427	657427	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:657427A>T	uc001qii.1	+	9	817	c.817A>T	c.(817-819)ACC>TCC	p.T273S	B4GALNT3_uc001qij.1_Missense_Mutation_p.T175S	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	273	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			AGCCAAGTTCACCATCATTGA	0.597000													9	37					0	0	0.010729	0	0	
VWF	7450	broad.mit.edu	37	12	6080778	6080778	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:6080778G>T	uc001qnn.1	-	44	7785	c.7535C>A	c.(7534-7536)TCT>TAT	p.S2512Y	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2512					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CTTCCAGGAAGACTGGGAGTC	0.622000													25	59					8.24728e-16	8.94878e-16	0.004656	1	0	
C1S	716	broad.mit.edu	37	12	7177878	7177878	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:7177878C>G	uc001qsj.2	+	15	2709	c.1990C>G	c.(1990-1992)CTC>GTC	p.L664V	C1S_uc001qsk.2_Missense_Mutation_p.L664V|C1S_uc001qsl.2_Missense_Mutation_p.L664V|C1S_uc009zfr.2_Missense_Mutation_p.L497V|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	664	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GACCTATGGGCTCTACACACG	0.537000													21	143					0	0	0.010504	0	0	
AICDA	57379	broad.mit.edu	37	12	8758006	8758006	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:8758006C>T	uc001qur.2	-	3	311	c.232G>A	c.(232-234)GTC>ATC	p.V78I	AICDA_uc001qup.1_Missense_Mutation_p.V73I|AICDA_uc001quq.1_Missense_Mutation_p.V73I|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	78					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					AACCAGGTGACGCGGTAGCAG	0.617000									Immune_Deficiency_with_Hyper-IgM				14	31					0	0	0.004007	0	0	
A2M	2	broad.mit.edu	37	12	9254148	9254148	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:9254148G>A	uc001qvk.1	-	12	1502	c.1389C>T	c.(1387-1389)CCC>CCT	p.P463P	A2M_uc009zgk.1_Silent_p.P313P	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	463					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CATGAGACATGGGCTCAAGGT	0.507000													8	31					0	0	0.003080	0	0	
KLRF1	51348	broad.mit.edu	37	12	9994946	9994946	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:9994946A>C	uc010sgw.1	+	6	565	c.501A>C	c.(499-501)CAA>CAC	p.Q167H	KLRF1_uc009zgw.2_Missense_Mutation_p.Q118H|KLRF1_uc009zgx.2_RNA|KLRF1_uc001qwm.2_RNA|KLRF1_uc009zgy.2_RNA|KLRF1_uc009zgz.2_Intron|KLRF1_uc009zha.2_Intron	NM_016523	NP_057607	Q9NZS2	KLRF1_HUMAN	killer cell lectin-like receptor subfamily F,	168	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			large_intestine(1)	1						ACCTAAGACAATTAAACTACG	0.333000													16	53					0	0	0.004990	0	0	
TAS2R7	50837	broad.mit.edu	37	12	10954529	10954529	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:10954529C>T	uc001qyv.2	-	1	698	c.641G>A	c.(640-642)CGA>CAA	p.R214Q		NM_023919	NP_076408	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	214	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						GAGCTGCATTCGCCTGATATG	0.512000													4	36					0	0	0.009096	0	0	
DDX47	51202	broad.mit.edu	37	12	12967079	12967079	+	Silent	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:12967079G>C	uc001rav.2	+	5	700	c.102G>C	c.(100-102)GTG>GTC	p.V34V	DDX47_uc009zhw.1_Silent_p.V34V|DDX47_uc001rax.2_Silent_p.V34V|DDX47_uc001ray.2_Silent_p.V34V|DDX47_uc010shn.1_Silent_p.V34V	NM_016355	NP_057439	Q9H0S4	DDX47_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	34	Q motif.					nucleolus|nucleolus	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding				0		Prostate(47;0.0526)		BRCA - Breast invasive adenocarcinoma(232;0.0354)		TGACAGATGTGTTGTGTGAAG	0.453000													9	172					0	0	0.006214	0	0	
C12orf69	440087	broad.mit.edu	37	12	14958991	14958991	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:14958991T>G	uc001rck.1	-	2	697	c.624A>C	c.(622-624)AAA>AAC	p.K208N	WBP11_uc001rci.2_5'Flank|C12orf60_uc001rcj.3_Intron	NM_001013698	NP_001013720	A2RU48	CL069_HUMAN	hypothetical protein LOC440087	208						integral to membrane					0						CATGATTATATTTTTCTGAGG	0.408000													40	67					0	0	0.008740	0	0	
H1FNT	341567	broad.mit.edu	37	12	48723523	48723523	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:48723523C>T	uc001rrm.2	+	1	761	c.449C>T	c.(448-450)GCG>GTG	p.A150V		NM_181788	NP_861453	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	150	Arg-rich.				chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			pancreas(1)	1						ACCCCAGCCGCGCCCCGGAGC	0.701000													10	11					0	0	0.006214	0	0	
KRT5	3852	broad.mit.edu	37	12	52908759	52908759	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:52908759G>A	uc001san.2	-	9	1903	c.1740C>T	c.(1738-1740)ACC>ACT	p.T580T		NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	580	Tail.|Ser-rich.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGAGGAGGTGGTGGAGACAA	0.607000													19	56					0	0	0.006122	0	0	
KRT78	196374	broad.mit.edu	37	12	53233611	53233611	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:53233611G>A	uc001sbc.1	-	7	1269	c.1205C>T	c.(1204-1206)ACG>ATG	p.T402M		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	402	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						GGAAAGCTTCGTGCTCGTCAG	0.612000													20	53					0	0	0.007413	0	0	
NCKAP1L	3071	broad.mit.edu	37	12	54914575	54914575	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:54914575T>G	uc001sgc.3	+	17	1802	c.1723T>G	c.(1723-1725)TTT>GTT	p.F575V	NCKAP1L_uc010sox.1_Missense_Mutation_p.F117V|NCKAP1L_uc010soy.1_Missense_Mutation_p.F525V	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	575					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TTGTGCTCACTTTGTCCACTG	0.463000													18	259					0	0	0.006122	0	0	
PTPRB	5787	broad.mit.edu	37	12	70965039	70965039	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:70965039C>T	uc001swb.3	-	11	2513	c.2483G>A	c.(2482-2484)CGC>CAC	p.R828H	PTPRB_uc010sto.1_Missense_Mutation_p.R828H|PTPRB_uc010stp.1_Missense_Mutation_p.R738H|PTPRB_uc001swc.3_Missense_Mutation_p.R1046H|PTPRB_uc001swa.3_Missense_Mutation_p.R958H|PTPRB_uc001swd.3_Missense_Mutation_p.R1045H|PTPRB_uc009zrr.1_Missense_Mutation_p.R925H	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	828	Fibronectin type-III 10.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GCTCCTGTTGCGCAATGTTAG	0.413000													3	23					0	0	0.004672	0	0	
NDUFA12	55967	broad.mit.edu	37	12	95397430	95397430	+	Silent	SNP	G	C	C	rs11554615		TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:95397430G>C	uc001tdl.2	-	1	82	c.27C>G	c.(25-27)CGC>CGG	p.R9R		NM_018838	NP_061326	Q9UI09	NDUAC_HUMAN	13kDa differentiation-associated protein	9					respiratory electron transport chain|respiratory gaseous exchange|response to oxidative stress|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	GCTGCAGCCCGCGTTTCAGGA	0.652000													45	69					0	0	0.014410	0	0	
UTP20	27340	broad.mit.edu	37	12	101759288	101759288	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:101759288T>G	uc001tia.1	+	46	6166	c.6010T>G	c.(6010-6012)TTA>GTA	p.L2004V		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2004					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TCATGAAACTTTACGCCGAAT	0.373000													5	21					0	0	0.001168	0	0	
ACACB	32	broad.mit.edu	37	12	109637357	109637357	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:109637357G>A	uc001tob.2	+	18	2897	c.2778G>A	c.(2776-2778)GAG>GAA	p.E926E	ACACB_uc001toc.2_Silent_p.E926E	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	926	Biotinyl-binding.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CTGAGATGGAGGTGACTGCAG	0.587000													12	58					0	0	0.013537	0	0	
ERP29	10961	broad.mit.edu	37	12	112460298	112460298	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:112460298T>G	uc001ttk.1	+	3	746	c.628T>G	c.(628-630)TTA>GTA	p.L210V	ERP29_uc001ttl.1_3'UTR	NM_006817	NP_006808	P30040	ERP29_HUMAN	endoplasmic reticulum protein 29 isoform 1	210					intracellular protein transport|protein folding|protein secretion	endoplasmic reticulum lumen|melanosome	protein disulfide isomerase activity				0						GGGGAAGATCTTAGACCAAGG	0.532000													12	48					0	0	0.013537	0	0	
C12orf51	283450	broad.mit.edu	37	12	112630954	112630954	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:112630954G>A	uc009zwc.2	-	51	7749	c.7731C>T	c.(7729-7731)TCC>TCT	p.S2577S		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CTTTGGATTCGGAAATTGGGA	0.473000													4	19					0	0	0.000602	0	0	
TPCN1	53373	broad.mit.edu	37	12	113705654	113705654	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:113705654G>A	uc001tuw.2	+	5	718	c.421G>A	c.(421-423)GCC>ACC	p.A141T	TPCN1_uc001tux.2_Missense_Mutation_p.A213T|TPCN1_uc010syt.1_Missense_Mutation_p.A73T	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	141	Helical; Name=S2 of repeat I; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TCAGGTCCACGCCACCCTGGA	0.612000													10	7					0	0	0.008291	0	0	
SBNO1	55206	broad.mit.edu	37	12	123812541	123812541	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr12:123812541A>C	uc010tap.1	-	10	1330	c.1330T>G	c.(1330-1332)TTA>GTA	p.L444V	SBNO1_uc010tao.1_Missense_Mutation_p.L443V|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.L444V|SBNO1_uc001ueu.2_Missense_Mutation_p.L443V|SBNO1_uc001uev.2_Missense_Mutation_p.L442V|SBNO1_uc009zxy.1_Missense_Mutation_p.L409V	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	444							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ACAGGACATAAGTTTTTGGCT	0.368000													7	96					0	0	0.008291	0	0	
SACS	26278	broad.mit.edu	37	13	23905608	23905608	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:23905608A>C	uc001uon.2	-	10	12996	c.12407T>G	c.(12406-12408)CTT>CGT	p.L4136R	SACS_uc001uoo.2_Missense_Mutation_p.L3989R|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4136					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TAAACTGTCAAGTTTCTCACC	0.383000													41	54					0	0	0.006999	0	0	
ATP12A	479	broad.mit.edu	37	13	25262594	25262594	+	Silent	SNP	C	T	T	rs150504279	by1000genomes	TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:25262594C>T	uc001upp.2	+	4	553	c.366C>T	c.(364-366)GGC>GGT	p.G122G	ATP12A_uc010aaa.2_Silent_p.G122G	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	122	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TGTGGGTGGGCGCCTTTCTCT	0.572000													67	258					0	0	0.014410	0	0	
RXFP2	122042	broad.mit.edu	37	13	32376379	32376379	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:32376379A>C	uc001utt.2	+	18	2173	c.2102A>C	c.(2101-2103)AAG>ACG	p.K701T	RXFP2_uc010aba.2_Missense_Mutation_p.K660T	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	701	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TTTAAGGACAAGTTGAAACAG	0.363000													16	69					0	0	0.003163	0	0	
STARD13	90627	broad.mit.edu	37	13	33859652	33859652	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:33859652T>G	uc001uuw.2	-	1	250	c.124A>C	c.(124-126)AGC>CGC	p.S42R	STARD13_uc001uux.2_Intron|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Intron	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	42					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AGAATCCGGCTCATCCTGTAA	0.498000													69	90					0	0	0.014410	0	0	
CCDC70	83446	broad.mit.edu	37	13	52439824	52439824	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:52439824G>A	uc001vfu.3	+	2	606	c.310G>A	c.(310-312)GAA>AAA	p.E104K	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	104						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		CTGGAAAGAGGAAAAATCCTT	0.473000													14	137					0	0	0.004007	0	0	
PCDH17	27253	broad.mit.edu	37	13	58299162	58299162	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:58299162T>A	uc001vhq.1	+	4	4106	c.3214T>A	c.(3214-3216)TTG>ATG	p.L1072M	PCDH17_uc010aec.1_Missense_Mutation_p.L1071M|PCDH17_uc001vhr.1_Missense_Mutation_p.L161M	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1072	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CAGTCAGTACTTGCCCACTGA	0.532000													48	53					0	0	0.014410	0	0	
LMO7	4008	broad.mit.edu	37	13	76427387	76427387	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:76427387G>A	uc001vjv.2	+	25	4585	c.3825G>A	c.(3823-3825)CGG>CGA	p.R1275R	LMO7_uc010thv.1_Silent_p.R1226R|LMO7_uc010thw.1_Silent_p.R1152R	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1560						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		CCTACATGCGGAACCCCTCCT	0.602000													5	31					0	0	0.000602	0	0	
EDNRB	1910	broad.mit.edu	37	13	78492700	78492700	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:78492700C>T	uc001vko.2	-	1	267	c.9G>A	c.(7-9)CCG>CCA	p.P3P	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Silent_p.P3P|EDNRB_uc010aez.1_Silent_p.P3P|EDNRB_uc001vkp.1_Silent_p.P86P|EDNRB_uc010afa.1_Silent_p.P3P	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	3					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GACTTGGAGGCGGCTGCATGC	0.642000											OREG0022452	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	17					0	0	0.004007	0	0	
RBM26	64062	broad.mit.edu	37	13	79940817	79940817	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:79940817G>A	uc001vkz.2	-	7	1100	c.1086C>T	c.(1084-1086)CCC>CCT	p.P362P	RBM26_uc001vky.2_Silent_p.P362P|RBM26_uc001vla.2_Silent_p.P362P|RBM26_uc001vkx.2_Silent_p.P74P|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	362	Pro-rich.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GTGGTACTGGGGGCCTGAGAT	0.527000													15	75					0	0	0.006122	0	0	
SLITRK1	114798	broad.mit.edu	37	13	84454576	84454576	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:84454576T>G	uc001vlk.2	-	1	1953	c.1067A>C	c.(1066-1068)AAG>ACG	p.K356T		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	356	Extracellular (Potential).|LRRNT 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCAGTTCATCTTTAAACCCGA	0.537000													8	66					0	0	0.003080	0	0	
SLITRK5	26050	broad.mit.edu	37	13	88329798	88329798	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:88329798G>A	uc001vln.2	+	2	2374	c.2155G>A	c.(2155-2157)GGC>AGC	p.G719S	SLITRK5_uc010tic.1_Missense_Mutation_p.G478S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	719	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CGTGTACGGCGGCGGCGGCGG	0.647000													38	43					0	0	0.006230	0	0	
UGGT2	55757	broad.mit.edu	37	13	96579548	96579548	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:96579548C>T	uc001vmt.2	-	18	2190	c.2020G>A	c.(2020-2022)GAT>AAT	p.D674N		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	674					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TTATTCCTATCCATTAGAAAA	0.299000													27	50					0	0	0.005443	0	0	
TFDP1	7027	broad.mit.edu	37	13	114290350	114290350	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr13:114290350G>A	uc001vtw.2	+	9	958	c.746G>A	c.(745-747)CGG>CAG	p.R249Q	TFDP1_uc010tkd.1_Missense_Mutation_p.R154Q|TFDP1_uc010tke.1_Missense_Mutation_p.R154Q|TFDP1_uc001vty.3_Missense_Mutation_p.R249Q|TFDP1_uc001vtx.2_Missense_Mutation_p.R129Q	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	249	Dimerization (Potential).|Enhances binding of RB protein to E2F.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			CAGGCCAGCCGGCCACCGCCA	0.552000										TSP Lung(29;0.18)			38	127					0	0	0.004878	0	0	
OR4K13	390433	broad.mit.edu	37	14	20502077	20502077	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr14:20502077G>T	uc010tkz.1	-	1	841	c.841C>A	c.(841-843)CTC>ATC	p.L281I		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GGATTTAAGAGAGGTGTGAAA	0.333000													28	31					2.12542e-12	2.26967e-12	0.006320	1	0	
RGS6	9628	broad.mit.edu	37	14	72926380	72926380	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr14:72926380A>C	uc001xna.3	+	6	906	c.383A>C	c.(382-384)AAC>ACC	p.N128T	RGS6_uc010ttn.1_Missense_Mutation_p.N128T|RGS6_uc001xmx.3_Missense_Mutation_p.N128T|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.N128T|RGS6_uc010ttp.1_Missense_Mutation_p.N59T|RGS6_uc001xmz.1_5'UTR|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	128					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		GAACCTGAAAACACTGACTAT	0.557000													8	95					0	0	0.006214	0	0	
KIAA0317	9870	broad.mit.edu	37	14	75139568	75139568	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr14:75139568G>C	uc001xqb.2	-	11	1893	c.1388C>G	c.(1387-1389)ACC>AGC	p.T463S	KIAA0317_uc010tut.1_Missense_Mutation_p.T302S|KIAA0317_uc001xqc.2_Missense_Mutation_p.T463S	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	463					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		GACCTTCAGGGTGACTTTGGA	0.453000													67	91					0	0	0.014410	0	0	
POMT2	29954	broad.mit.edu	37	14	77778318	77778318	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr14:77778318A>G	uc001xti.2	-	2	508	c.307T>C	c.(307-309)TTT>CTT	p.F103L	POMT2_uc010asr.2_Intron	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	103	Helical; (Potential).				protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		TGCACATCAAAGAAAAATGTA	0.423000													15	20					0	0	0.002450	0	0	
KIAA1409	57578	broad.mit.edu	37	14	94112973	94112973	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr14:94112973T>A	uc001ybv.1	+	34	5799	c.5716T>A	c.(5716-5718)TTT>ATT	p.F1906I	KIAA1409_uc001ybs.1_Missense_Mutation_p.F1884I	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2061						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CAGTACTACCTTTTCTAATCA	0.403000													8	38					0	0	0.006214	0	0	
CLMN	79789	broad.mit.edu	37	14	95669187	95669187	+	Missense_Mutation	SNP	C	A	A	rs150763369	byFrequency	TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr14:95669187C>A	uc001yef.2	-	9	2615	c.2499G>T	c.(2497-2499)ATG>ATT	p.M833I		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	833						integral to membrane	actin binding				0				Epithelial(152;0.193)		GATGGCTGTCCATGGGGTCAT	0.557000													13	94					6.31663e-08	6.66991e-08	0.003163	1	0	
DIO3	1735	broad.mit.edu	37	14	102028220	102028220	+	Silent	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr14:102028220G>T	uc010txq.1	+	1	533	c.309G>T	c.(307-309)GCG>GCT	p.A103A	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	103	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				TCAAGCAGGCGCACGAGGGCG	0.657000													12	58					1.49906e-05	1.56539e-05	0.002450	1	0	
AHNAK2	113146	broad.mit.edu	37	14	105415965	105415965	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr14:105415965T>G	uc010axc.1	-	7	5943	c.5823A>C	c.(5821-5823)GAA>GAC	p.E1941D	AHNAK2_uc001ypx.2_Missense_Mutation_p.E1841D	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1941						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGCTGTCACTTCCGCCTTGG	0.607000													7	294					0	0	0.003080	0	0	
ADAM6	8755	broad.mit.edu	37	14	107183695	107183695	+	RNA	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr14:107183695C>A	uc010tyt.1	-	29		c.1862G>T								Parts of antibodies, mostly variable regions.												0						CCAGCTGCACCTCACACTGGA	0.517000													16	78					2.23348e-06	2.34789e-06	0.004007	1	0	
WHAMML1	339005	broad.mit.edu	37	15	23205098	23205098	+	RNA	SNP	G	A	A	rs146035894	by1000genomes	TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr15:23205098G>A	uc001yvg.2	-	2		c.697C>T			WHAMML1_uc010ayc.2_RNA|WHAMML1_uc010ayd.2_RNA|WHAMML1_uc010aye.1_RNA	NR_003521				Homo sapiens mRNA; cDNA DKFZp313L2232 (from clone DKFZp313L2232).												0						CTGGAAGAACGTGGTTGCCAC	0.373000													3	13					0	0	0.009096	0	0	
SNORD116-4	100033416	broad.mit.edu	37	15	25339114	25339114	+	RNA	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr15:25339114T>C	uc001yxh.1	+	19		c.2661T>C			SNORD116-4_uc001yxm.1_RNA|IPW_uc001yxn.3_RNA|SNORD116-28_uc001yxy.2_RNA|IPW_uc001yyb.3_RNA|uc001yyd.2_RNA|uc001yyi.1_5'Flank|SNORD116-24_uc001yyj.2_5'Flank					Homo sapiens clone kid4 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0						GGTGGATCCCTCAGGATGGTA	0.473000													15	21					0	0	0.002450	0	0	
C15orf55	256646	broad.mit.edu	37	15	34649257	34649257	+	Silent	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr15:34649257T>G	uc001zif.2	+	7	3119	c.2964T>G	c.(2962-2964)ACT>ACG	p.T988T	C15orf55_uc010ucc.1_Silent_p.T1016T|C15orf55_uc010ucd.1_Silent_p.T1006T	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	988						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CGAGAGAAACTTCTGTTAGTA	0.473000			T	BRD3|BRD4	lethal midline carcinoma								4	31					0	0	0.009096	0	0	
LOC723972	723972	broad.mit.edu	37	15	35530228	35530228	+	RNA	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr15:35530228A>C	uc001ziy.2	+	1		c.702A>C				NR_003144				Homo sapiens hepatopoietin PCn127 mRNA, complete cds.												0						AGAAGCGAAAAGGAGAACCTG	0.373000													8	25					0	0	0.004482	0	0	
TLN2	83660	broad.mit.edu	37	15	62945507	62945507	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr15:62945507G>A	uc002alb.3	+	4	511	c.511G>A	c.(511-513)GAT>AAT	p.D171N		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	171	FERM.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						GCACACAGATGATGACCGTAA	0.473000													13	22					0	0	0.001855	0	0	
HERC1	8925	broad.mit.edu	37	15	63926976	63926976	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr15:63926976G>A	uc002amp.2	-	66	12674	c.12526C>T	c.(12526-12528)CTT>TTT	p.L4176F		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4176	RCC1 11.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CTCTCTGGAAGTTTTTTGTTA	0.423000													4	14					0	0	0.009096	0	0	
GOLGA6L10	647042	broad.mit.edu	37	15	83014132	83014132	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr15:83014132C>G	uc010uny.1	-	6	513	c.415G>C	c.(415-417)GAG>CAG	p.E139Q	GOLGA6L10_uc010unt.1_RNA|uc002bhl.2_Intron|uc002bhm.2_Intron|GOLGA6L10_uc002bia.1_5'Flank	NM_198181	NP_937824	A6NI86	GG6LA_HUMAN	golgi autoantigen, golgin subfamily a, 6D-like	151											0						GCTGGGGGCTCTGGGGCCAGG	0.522000													4	16					0	0	0.009096	0	0	
Unknown	0	broad.mit.edu	37	15	102312686	102312686	+	RNA	SNP	C	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr15:102312686C>G	uc010utm.1	+	1		c.11C>G			uc002ccq.3_5'Flank|uc010utn.1_5'Flank|uc002ccs.1_5'Flank|uc010uto.1_5'Flank|uc002cct.1_5'Flank|uc002ccu.2_5'Flank|uc002ccv.1_5'Flank|uc002ccw.2_5'Flank|uc010utp.1_5'Flank					DQ596604																		TAAGGCCACTCTGGAGCCAAA	0.552000													29	73					0	0	0.006320	0	0	
WDR90	197335	broad.mit.edu	37	16	705073	705073	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:705073G>A	uc002cii.1	+	14	1536	c.1482G>A	c.(1480-1482)GAG>GAA	p.E494E	WDR90_uc002cig.1_Silent_p.E494E|WDR90_uc002cih.1_Silent_p.E495E|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_5'UTR|WDR90_uc002cil.1_5'Flank|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	494	WD 2.									ovary(1)	1		Hepatocellular(780;0.0218)				TCGGTGGCGAGGTGGTCGTTC	0.642000													8	50					0	0	0.003080	0	0	
ZG16B	124220	broad.mit.edu	37	16	2882108	2882108	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:2882108C>T	uc002cru.2	+	4	651	c.575C>T	c.(574-576)ACT>ATT	p.T192I		NM_145252	NP_660295	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16 homolog B precursor	192						extracellular region	sugar binding			ovary(1)	1						GAGCCGACCACTGAGCCACCA	0.562000													22	74					0	0	0.002780	0	0	
GRIN2A	2903	broad.mit.edu	37	16	9934899	9934899	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:9934899A>G	uc002czo.3	-	6	1939	c.1391T>C	c.(1390-1392)CTG>CCG	p.L464P	GRIN2A_uc010uym.1_Missense_Mutation_p.L464P|GRIN2A_uc010uyn.1_Missense_Mutation_p.L307P|GRIN2A_uc002czr.3_Missense_Mutation_p.L464P	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	464	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAGCTTCTTCAGAATATCAAT	0.353000													14	58					0	0	0.003163	0	0	
Unknown	0	broad.mit.edu	37	16	21854796	21854796	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:21854796T>G	uc002djr.3	-	6	638	c.456A>C	c.(454-456)AAA>AAC	p.K152N	uc002djs.3_RNA|uc002djq.3_Missense_Mutation_p.K133N|uc010vbn.1_Missense_Mutation_p.K152N	NM_130464	NP_569731			nuclear pore complex interacting protein-like 3																		TAGCTCTAACTTTTGTTTCCA	0.393000													48	165					0	0	0.014410	0	0	
USP31	57478	broad.mit.edu	37	16	23080245	23080245	+	Missense_Mutation	SNP	G	C	C	rs151219972	by1000genomes	TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:23080245G>C	uc002dll.2	-	16	3181	c.3181C>G	c.(3181-3183)CCT>GCT	p.P1061A	USP31_uc002dlk.2_Missense_Mutation_p.P333A|USP31_uc010vca.1_Missense_Mutation_p.P364A|USP31_uc010bxm.2_Missense_Mutation_p.P349A	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1061	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		ACAGGAAGAGGAGAAGAAGGG	0.557000													40	54					0	0	0.007835	0	0	
NSMCE1	197370	broad.mit.edu	37	16	27238064	27238064	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:27238064T>C	uc002doi.1	-	6	675	c.577A>G	c.(577-579)ATC>GTC	p.I193V	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	193	NSE1-type.				DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						CTGTGACAGATATTGCAGATC	0.627000													25	41					0	0	0.004656	0	0	
CYLD	1540	broad.mit.edu	37	16	50825577	50825577	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:50825577C>G	uc002egp.1	+	15	2632	c.2217C>G	c.(2215-2217)ATC>ATG	p.I739M	CYLD_uc010cbs.1_Missense_Mutation_p.I736M|CYLD_uc002egq.1_Missense_Mutation_p.I736M|CYLD_uc002egr.1_Missense_Mutation_p.I736M	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	739					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				GGTCTTTTATCAACAGTAACC	0.348000			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				21	49					0	0	0.014323	0	0	
GPR97	222487	broad.mit.edu	37	16	57707259	57707259	+	Silent	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:57707259A>C	uc002emh.2	+	2	188	c.85A>C	c.(85-87)AGA>CGA	p.R29R	GPR97_uc010cdc.2_Silent_p.R29R|GPR97_uc010vhv.1_5'UTR|GPR97_uc010cdd.2_RNA	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	29	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						CGAAGGGCCAAGAAACACCTG	0.443000													8	40					0	0	0.003080	0	0	
C16orf46	123775	broad.mit.edu	37	16	81095607	81095607	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:81095607T>C	uc002fgc.3	-	4	606	c.347A>G	c.(346-348)AAG>AGG	p.K116R	C16orf46_uc010chf.2_Missense_Mutation_p.K116R|C16orf46_uc010vno.1_5'UTR	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	116											0						AGTAGGAGGCTTGGTCTGGAG	0.617000													5	127					0	0	0.000602	0	0	
SNAI3	333929	broad.mit.edu	37	16	88748082	88748082	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr16:88748082C>T	uc002flj.2	-	2	185	c.117G>A	c.(115-117)GTG>GTA	p.V39V	MGC23284_uc002fli.3_Intron	NM_178310	NP_840101	Q3KNW1	SNAI3_HUMAN	snail homolog 3	39					oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.048)		GGAGGAGGGGCACCACCAGCC	0.632000													20	11					0	0	0.002780	0	0	
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	rs28934576	by1000genomes	TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	16					0	0	0.004482	0	0	
GLP2R	9340	broad.mit.edu	37	17	9792877	9792877	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:9792877C>A	uc002gmd.1	+	13	1517	c.1517C>A	c.(1516-1518)GCC>GAC	p.A506D		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	506	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	CTACATCTAGCCATGCGAGGT	0.622000													22	29					7.45023e-12	7.90226e-12	0.010504	1	0	
MYH1	4619	broad.mit.edu	37	17	10415739	10415739	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:10415739G>A	uc002gmo.2	-	12	1227	c.1133C>T	c.(1132-1134)CCA>CTA	p.P378L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	378	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						AGTGCCATCTGGCTCAGCTTG	0.423000													5	81					0	0	0.000602	0	0	
MYO15A	51168	broad.mit.edu	37	17	18044113	18044113	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:18044113G>A	uc010vxh.1	+	20	5711	c.5373G>A	c.(5371-5373)TTG>TTA	p.L1791L		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1791	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCAACCCCTTGTTCATGCGTT	0.502000											OREG0024223	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	25					0	0	0.014410	0	0	
SLFN12L	342615	broad.mit.edu	37	17	33802293	33802293	+	Silent	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:33802293T>G	uc002hjn.2	-	5	2382	c.1503A>C	c.(1501-1503)CCA>CCC	p.P501P		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						TGTATAGGACTGGAGGCTTGT	0.453000													11	48					0	0	0.013537	0	0	
GJD3	125111	broad.mit.edu	37	17	38520012	38520012	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:38520012G>A	uc010cwz.2	-	1	934	c.56C>T	c.(55-57)CCG>CTG	p.P19L	uc010cxa.1_Missense_Mutation_p.R275Q	NM_152219	NP_689343	Q8N144	CXD3_HUMAN	gap junction protein, delta 3, 31.9kDa	19	Cytoplasmic (Potential).				cell communication|gap junction assembly	cell surface|connexon complex|integral to plasma membrane	protein binding				0		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)			GCCCACGAGCGGCGACTGCAG	0.701000													6	13					0	0	0.001168	0	0	
MLX	6945	broad.mit.edu	37	17	40721590	40721590	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:40721590C>T	uc002iag.2	+	6	669	c.604C>T	c.(604-606)CGC>TGC	p.R202C	MLX_uc002iaf.2_Missense_Mutation_p.R148C|MLX_uc002iah.2_Missense_Mutation_p.R118C	NM_170607	NP_733752	Q9UH92	MLX_HUMAN	transcription factor-like protein 4 isoform	202					energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)		GTCCACGTTACGCAAGGATGT	0.498000													14	34					0	0	0.003163	0	0	
MED13	9969	broad.mit.edu	37	17	60033154	60033154	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:60033154T>G	uc002izo.2	-	25	5746	c.5669A>C	c.(5668-5670)AAA>ACA	p.K1890T		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1890					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TTTGAGCCTTTTACTTAGAGA	0.403000													11	50					0	0	0.010729	0	0	
MRC2	9902	broad.mit.edu	37	17	60742114	60742114	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:60742114C>T	uc002jad.2	+	2	726	c.324C>T	c.(322-324)GGC>GGT	p.G108G	MRC2_uc002jac.2_Silent_p.G108G	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	108	Extracellular (Potential).|Ricin B-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCTCCCTGGGCATGTATGAGT	0.607000													11	49					0	0	0.010729	0	0	
BPTF	2186	broad.mit.edu	37	17	65888127	65888127	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:65888127A>G	uc002jgf.2	+	5	2093	c.2032A>G	c.(2032-2034)AAA>GAA	p.K678E	BPTF_uc002jge.2_Missense_Mutation_p.K804E|BPTF_uc010wqm.1_Missense_Mutation_p.K741E	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	804					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGAAGCAAATAAATTATTTAA	0.408000													11	17					0	0	0.010729	0	0	
NUP85	79902	broad.mit.edu	37	17	73231771	73231771	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:73231771C>T	uc002jng.1	+	19	2228	c.1968C>T	c.(1966-1968)TCC>TCT	p.S656S	NUP85_uc010dgd.1_Silent_p.S611S|NUP85_uc010wrv.1_Silent_p.S610S|NUP85_uc002jnh.1_Silent_p.S259S	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	656					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			TGGAAGGTTCCTGAGAACTGC	0.398000													5	53					0	0	0.001168	0	0	
SYNGR2	9144	broad.mit.edu	37	17	76167882	76167882	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr17:76167882T>A	uc002juu.1	+	4	567	c.540T>A	c.(538-540)AAT>AAA	p.N180K	SYNGR2_uc002jut.2_Missense_Mutation_p.I210N|SYNGR2_uc002juv.1_Missense_Mutation_p.L134I|SYNGR2_uc010dhi.1_RNA	NM_004710	NP_004701	O43760	SNG2_HUMAN	synaptogyrin 2	180						integral to plasma membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			TCATCCAGAATTACGTTGACC	0.627000													6	92					0	0	0.001984	0	0	
CLUL1	27098	broad.mit.edu	37	18	633357	633357	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:633357G>A	uc002kkp.2	+	6	1061	c.916G>A	c.(916-918)GGG>AGG	p.G306R	CLUL1_uc010wys.1_Missense_Mutation_p.G358R|CLUL1_uc002kkq.2_Missense_Mutation_p.G306R	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	306					cell death	extracellular region				ovary(2)	2						AGGACTGTGTGGGGAACTTGA	0.403000													19	37					0	0	0.008871	0	0	
ANKRD12	23253	broad.mit.edu	37	18	9256587	9256587	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:9256587G>A	uc002knv.2	+	9	3579	c.3322G>A	c.(3322-3324)GAA>AAA	p.E1108K	ANKRD12_uc002knw.2_Missense_Mutation_p.E1085K|ANKRD12_uc002knx.2_Missense_Mutation_p.E1085K|ANKRD12_uc010dkx.1_Missense_Mutation_p.E815K	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1108						nucleus				ovary(2)|central_nervous_system(1)	3						AAAAGAAAAGGAACGGTTGAG	0.308000													10	86					0	0	0.006214	0	0	
SPIRE1	56907	broad.mit.edu	37	18	12463377	12463377	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:12463377C>T	uc002kre.2	-	12	1658	c.1611G>A	c.(1609-1611)CCG>CCA	p.P537P	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Silent_p.P403P|SPIRE1_uc010wzx.1_Silent_p.P326P|SPIRE1_uc010wzy.1_Silent_p.P523P	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	537						cytoskeleton|perinuclear region of cytoplasm	actin binding				0						GCCTGGAAGGCGGCAGGAACT	0.488000													23	59					0	0	0.006320	0	0	
CEP192	55125	broad.mit.edu	37	18	13059133	13059133	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:13059133G>A	uc010xac.1	+	21	4390	c.4310G>A	c.(4309-4311)AGA>AAA	p.R1437K	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.R962K|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Missense_Mutation_p.R1178K	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1437										ovary(4)|pancreas(1)	5						GCCATCATAAGACCTCATGCC	0.383000													4	136					0	0	0.001168	0	0	
POTEC	388468	broad.mit.edu	37	18	14542958	14542958	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:14542958T>G	uc010dln.2	-	1	642	c.188A>C	c.(187-189)AAG>ACG	p.K63T	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	63										skin(3)	3						GTGGCAACACTTGCCCATCTT	0.587000													80	257					0	0	0.014410	0	0	
TTR	7276	broad.mit.edu	37	18	29172975	29172975	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:29172975G>T	uc002kwx.3	+	2	322	c.186G>T	c.(184-186)GAG>GAT	p.E62D		NM_000371	NP_000362	P02766	TTHY_HUMAN	transthyretin precursor	62					transport	cytoplasm	hormone activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.00523)		Diclofenac(DB00586)|Diethylstilbestrol(DB00255)|Diflunisal(DB00861)|Dimethyl sulfoxide(DB01093)|Levothyroxine(DB00451)|Liothyronine(DB00279)	ACACCTGGGAGCCATTTGCCT	0.522000													32	62					9.78306e-22	1.07137e-21	0.009535	1	0	
FHOD3	80206	broad.mit.edu	37	18	34205506	34205506	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:34205506C>T	uc002kzt.1	+	10	1087	c.990C>T	c.(988-990)ACC>ACT	p.T330T	FHOD3_uc002kzr.1_Silent_p.T330T|FHOD3_uc002kzs.1_Silent_p.T330T|FHOD3_uc002kzu.1_Silent_p.T155T|FHOD3_uc010dmz.1_Silent_p.T83T	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	330	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				GCGATGAGACCACGGAGCCAC	0.667000													35	46					0	0	0.013726	0	0	
FHOD3	80206	broad.mit.edu	37	18	34289206	34289206	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:34289206G>A	uc002kzt.1	+	14	1906	c.1809G>A	c.(1807-1809)CCG>CCA	p.P603P	FHOD3_uc002kzr.1_Silent_p.P603P|FHOD3_uc002kzs.1_Silent_p.P620P|FHOD3_uc010dmz.1_Silent_p.P335P|FHOD3_uc010dna.1_5'UTR	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	603					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				AGCAAGAGCCGGAAGAAAGAG	0.607000													36	71					0	0	0.004289	0	0	
CDH20	28316	broad.mit.edu	37	18	59157803	59157803	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:59157803G>T	uc010dps.1	+	1	29	c.17G>T	c.(16-18)AGA>ATA	p.R6I	CDH20_uc002lif.2_5'UTR	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	6					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				ACTTCTGGTAGAATGAGCAAT	0.443000													53	90					3.00063e-23	3.29371e-23	0.014410	1	0	
RTTN	25914	broad.mit.edu	37	18	67802494	67802494	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:67802494A>T	uc002lkp.2	-	22	2879	c.2811T>A	c.(2809-2811)GAT>GAA	p.D937E	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.D25E	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	937							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				CGACACTACAATCTTCATGAA	0.279000													5	89					0	0	0.001984	0	0	
ZNF516	9658	broad.mit.edu	37	18	74154244	74154244	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:74154244G>T	uc010dqx.1	-	2	1002	c.767C>A	c.(766-768)GCC>GAC	p.A256D	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	256	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CTGGCTGAAGGCCTGGCCACA	0.687000													5	19					1.23904e-05	1.29673e-05	0.000602	1	0	
PQLC1	80148	broad.mit.edu	37	18	77679395	77679395	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr18:77679395C>T	uc002lnl.2	-	5	569	c.397G>A	c.(397-399)GAC>AAC	p.D133N	PQLC1_uc010dre.2_Missense_Mutation_p.D50N|PQLC1_uc002lnk.2_Missense_Mutation_p.D115N|PQLC1_uc010xfm.1_Intron	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	133						integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		TGGTGGGGGTCGAAGTCTAGG	0.607000													11	18					0	0	0.010729	0	0	
MIDN	90007	broad.mit.edu	37	19	1257094	1257094	+	Silent	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:1257094G>C	uc002lrp.2	+	8	1745	c.1230G>C	c.(1228-1230)CGG>CGC	p.R410R		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	410						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGCCCGGCGGGACGCGCGGG	0.716000													3	35					0	0	0.004672	0	0	
EMR1	2015	broad.mit.edu	37	19	6921816	6921816	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:6921816A>G	uc002mfw.2	+	14	1751	c.1713A>G	c.(1711-1713)GAA>GAG	p.E571E	EMR1_uc010dvc.2_Silent_p.E571E|EMR1_uc010dvb.2_Silent_p.E519E|EMR1_uc010xji.1_Silent_p.E430E|EMR1_uc010xjj.1_Silent_p.E394E	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	571	GPS.|Extracellular (Potential).|Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TGATCCTGGAAGCTTCTGAGA	0.478000													4	106					0	0	0.009096	0	0	
MUC16	94025	broad.mit.edu	37	19	9046074	9046074	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:9046074G>A	uc002mkp.2	-	5	35761	c.35557C>T	c.(35557-35559)CAT>TAT	p.H11853Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11855	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCCCTGGATGGGTGGAAAGT	0.483000													60	51					0	0	0.014410	0	0	
MUC16	94025	broad.mit.edu	37	19	9062990	9062990	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:9062990T>G	uc002mkp.2	-	3	24660	c.24456A>C	c.(24454-24456)GAA>GAC	p.E8152D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8154	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCTGGAGACTTCAGCAGTGG	0.542000													46	77					0	0	0.014410	0	0	
CPAMD8	27151	broad.mit.edu	37	19	17108002	17108002	+	Silent	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:17108002G>T	uc002nfb.2	-	11	1187	c.1155C>A	c.(1153-1155)CCC>CCA	p.P385P		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	338						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GCCTCTGCACGGGGGTGGAGT	0.642000													15	29					1.56452e-12	1.6745e-12	0.007413	1	0	
MYO9B	4650	broad.mit.edu	37	19	17283571	17283571	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:17283571T>G	uc010eak.2	+	13	2091	c.1939T>G	c.(1939-1941)TTC>GTC	p.F647V	MYO9B_uc002nfi.2_Missense_Mutation_p.F647V|MYO9B_uc002nfj.1_Missense_Mutation_p.F647V	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	647	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CCACCAGGACTTCCGGGAGAA	0.657000													6	97					0	0	0.003080	0	0	
MYO9B	4650	broad.mit.edu	37	19	17322769	17322769	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:17322769G>A	uc010eak.2	+	40	6276	c.6124G>A	c.(6124-6126)GCC>ACC	p.A2042T	MYO9B_uc002nfi.2_3'UTR|MYO9B_uc002nfm.1_3'UTR	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	2042	Tail.			TVAAPP -> PWPPLH (in Ref. 3; AAC26597).	actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CACCGTGGCCGCCCCTCCACG	0.687000													3	5					0	0	0.004672	0	0	
IL12RB1	3594	broad.mit.edu	37	19	18180500	18180500	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:18180500C>T	uc002nhw.1	-	10	1109	c.1045G>A	c.(1045-1047)GTC>ATC	p.V349I	IL12RB1_uc010xqb.1_Missense_Mutation_p.V349I|IL12RB1_uc002nhx.1_Missense_Mutation_p.V389I	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	349	Extracellular (Potential).|Fibronectin type-III 4.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						TTGGTTCCGACGCTGATATTC	0.602000													24	74					0	0	0.007291	0	0	
ZNF208	7757	broad.mit.edu	37	19	22155008	22155008	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:22155008T>G	uc002nqp.2	-	5	2677	c.2528A>C	c.(2527-2529)AAA>ACA	p.K843T	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTGTAGAATTTCTCTCCAGC	0.363000													3	35					0	0	0.004672	0	0	
ZNF676	163223	broad.mit.edu	37	19	22364289	22364289	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:22364289T>A	uc002nqs.1	-	3	548	c.230A>T	c.(229-231)GAG>GTG	p.E77V		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GTGTAAATTCTCATGTCCACA	0.338000													23	58					0	0	0.002780	0	0	
ZNF99	7652	broad.mit.edu	37	19	22941224	22941224	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:22941224A>G	uc010xrh.1	-	5	1214	c.1214T>C	c.(1213-1215)CTT>CCT	p.L405P		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ATGTACAGTAAGTTTTGAGGA	0.348000													15	38					0	0	0.004990	0	0	
CLIP3	25999	broad.mit.edu	37	19	36515470	36515470	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:36515470G>T	uc010eeq.1	-	6	1028	c.746C>A	c.(745-747)GCA>GAA	p.A249E	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.A249E	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	249					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TGCCGCCTCTGCCTTGTCCAG	0.597000													6	44					1.12685e-05	1.18194e-05	0.004482	1	0	
ZFP14	57677	broad.mit.edu	37	19	36831555	36831555	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:36831555A>G	uc002odx.1	-	4	1266	c.1173T>C	c.(1171-1173)ACT>ACC	p.T391T	ZFP14_uc010xtd.1_Silent_p.T392T|ZFP14_uc010eex.1_Silent_p.T391T	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					GTTTCTCACGAGTATGTATTC	0.393000													30	29					0	0	0.009535	0	0	
CD177	57126	broad.mit.edu	37	19	43866347	43866347	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:43866347G>A	uc002owi.2	+	10	1231	c.1189G>A	c.(1189-1191)GAT>AAT	p.D397N	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	397					blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				TGAGAAGCGTGATGTGCAGCC	0.612000													14	75					0	0	0.003163	0	0	
CCDC8	83987	broad.mit.edu	37	19	46915030	46915030	+	Silent	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:46915030C>A	uc002pep.2	-	1	1890	c.1038G>T	c.(1036-1038)GGG>GGT	p.G346G		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	346						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CAGCTGGGGCCCCTGCCCTCT	0.622000													15	167					5.01169e-05	5.2104e-05	0.004990	1	0	
PNKP	11284	broad.mit.edu	37	19	50370414	50370414	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:50370414A>G	uc002pqh.2	-	1	100	c.48T>C	c.(46-48)CCT>CCC	p.P16P	PNKP_uc002pqg.2_5'Flank|PNKP_uc002pqi.2_5'UTR|PNKP_uc002pqj.2_Silent_p.P16P|PNKP_uc010enm.2_Silent_p.P16P|PNKP_uc002pqk.2_Silent_p.P16P	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	16					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		GCGCTCCCCCAGGGGGGCTCT	0.721000								Other_BER_factors					12	23					0	0	0.013537	0	0	
SIGLEC11	114132	broad.mit.edu	37	19	50461825	50461825	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:50461825G>A	uc010ybh.1	-	8	1457	c.1366C>T	c.(1366-1368)CCT>TCT	p.P456S	SIGLEC11_uc010ybi.1_Intron	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	456	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		AGCTGTGGAGGGTCTGTGGGG	0.692000													10	19					0	0	0.008291	0	0	
MYBPC2	4606	broad.mit.edu	37	19	50949194	50949194	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:50949194C>T	uc002psf.2	+	12	1242	c.1191C>T	c.(1189-1191)TTC>TTT	p.F397F		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	397	Ig-like C2-type 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GGTACCGCTTCAAGAAGGACG	0.572000													6	18					0	0	0.001168	0	0	
ZNF614	80110	broad.mit.edu	37	19	52520427	52520427	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:52520427T>A	uc002pyj.2	-	5	826	c.424A>T	c.(424-426)AGT>TGT	p.S142C	ZNF614_uc002pyi.3_Missense_Mutation_p.S142C|ZNF614_uc010epj.2_Translation_Start_Site	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TTGATTAAACTTAAACTTGAT	0.328000													6	43					0	0	0.001168	0	0	
ZNF583	147949	broad.mit.edu	37	19	56935669	56935669	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr19:56935669T>G	uc010ygl.1	+	5	1807	c.1642T>G	c.(1642-1644)TTG>GTG	p.L548V	ZNF583_uc002qnc.2_Missense_Mutation_p.L548V|ZNF583_uc010ygm.1_Missense_Mutation_p.L548V	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		ggagtcattcttgactctttc	0.174000													11	14					0	0	0.008291	0	0	
MSGN1	343930	broad.mit.edu	37	2	17998077	17998077	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:17998077T>G	uc010yjt.1	+	1	292	c.292T>G	c.(292-294)TTA>GTA	p.L98V		NM_001105569	NP_001099039	A6NI15	MSGN1_HUMAN	mesogenin 1	98					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTACAATATGTTAGCTTTCCA	0.657000													4	52					0	0	0.009096	0	0	
DNAJC5G	285126	broad.mit.edu	37	2	27503062	27503062	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:27503062A>C	uc002rjl.1	+	6	967	c.549A>C	c.(547-549)GAA>GAC	p.E183D	TRIM54_uc002rjn.2_5'Flank|TRIM54_uc002rjo.2_5'Flank|DNAJC5G_uc010yli.1_Missense_Mutation_p.K96T|DNAJC5G_uc002rjm.1_Missense_Mutation_p.E183D	NM_173650	NP_775921	Q8N7S2	DNJ5G_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	183					protein folding	membrane	heat shock protein binding|unfolded protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAGCGAGGAAAATAGCGAAG	0.338000											OREG0014517	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	86	110					0	0	0.014410	0	0	
SUPT7L	9913	broad.mit.edu	37	2	27880285	27880285	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:27880285C>T	uc002rlh.1	-	4	1014	c.671G>A	c.(670-672)GGT>GAT	p.G224D	SUPT7L_uc002rli.1_Missense_Mutation_p.G224D|SUPT7L_uc010ymf.1_Missense_Mutation_p.G89D|SUPT7L_uc002rlj.1_Missense_Mutation_p.G222D|SUPT7L_uc010ezh.1_Missense_Mutation_p.G222D	NM_014860	NP_055675	O94864	ST65G_HUMAN	SPTF-associated factor 65 gamma	224					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					ACTGCCAATACCCACTTCATG	0.532000													24	23					0	0	0.003330	0	0	
CLIP4	79745	broad.mit.edu	37	2	29383324	29383324	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:29383324T>G	uc002rmv.2	+	12	1764	c.1525T>G	c.(1525-1527)TTC>GTC	p.F509V	CLIP4_uc002rmu.2_Missense_Mutation_p.F509V|CLIP4_uc010ezm.1_Missense_Mutation_p.F509V|CLIP4_uc002rmw.2_RNA	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	509	CAP-Gly 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GACAACAAACTTCGCTCCAGG	0.393000													4	63					0	0	0.009096	0	0	
ALK	238	broad.mit.edu	37	2	29450510	29450510	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:29450510G>A	uc002rmy.2	-	17	3751	c.2844C>T	c.(2842-2844)CCC>CCT	p.P948P		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	948	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CATCCATTTCGGGGTCATTGT	0.512000			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				21	88					0	0	0.012319	0	0	
ALK	238	broad.mit.edu	37	2	29754908	29754908	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:29754908C>G	uc002rmy.2	-	4	1934	c.1027G>C	c.(1027-1029)GAG>CAG	p.E343Q		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	343	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GTGCAGTGCTCACTGCTGCTC	0.577000			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				29	23					0	0	0.010818	0	0	
MYADML	151325	broad.mit.edu	37	2	33952741	33952741	+	Silent	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:33952741G>T	uc002rpb.2	-	1	544	c.102C>A	c.(100-102)CTC>CTA	p.L34L		NR_003143				RecName: Full=Myeloid-associated differentiation marker-like protein.;												0						AGAGGCACAAGAGGGCCGCAT	0.637000													20	22					1.87028e-06	1.97048e-06	0.012319	1	0	
STRN	6801	broad.mit.edu	37	2	37096829	37096829	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:37096829T>G	uc002rpn.2	-	11	1376	c.1367A>C	c.(1366-1368)AAG>ACG	p.K456T	STRN_uc010ezx.2_Missense_Mutation_p.K419T	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	456					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				CAATGTAAACTTAGGGTTCCA	0.368000													3	32					0	0	0.004672	0	0	
HEATR5B	54497	broad.mit.edu	37	2	37289138	37289138	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:37289138A>G	uc002rpp.1	-	11	1736	c.1640T>C	c.(1639-1641)CTA>CCA	p.L547P		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	547							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				CTGTAAAGATAGCCTGCTATT	0.363000													24	65					0	0	0.007291	0	0	
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48896962	48896962	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:48896962A>C	uc010yol.1	+	6	3098	c.3051A>C	c.(3049-3051)GAA>GAC	p.E1017D	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.E1064D|GTF2A1L_uc002rws.1_Missense_Mutation_p.E360D|GTF2A1L_uc010yom.1_Missense_Mutation_p.E326D|GTF2A1L_uc002rwt.2_Missense_Mutation_p.E360D	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	1017					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CCAATGAAGAAATAGGAAGTA	0.378000													6	79					0	0	0.001168	0	0	
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48896972	48896972	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:48896972A>G	uc010yol.1	+	6	3108	c.3061A>G	c.(3061-3063)ACA>GCA	p.T1021A	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.T1068A|GTF2A1L_uc002rws.1_Missense_Mutation_p.T364A|GTF2A1L_uc010yom.1_Missense_Mutation_p.T330A|GTF2A1L_uc002rwt.2_Missense_Mutation_p.T364A	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	1021					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AATAGGAAGTACAAGAGATGC	0.393000													7	67					0	0	0.001984	0	0	
CCDC88A	55704	broad.mit.edu	37	2	55527028	55527028	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:55527028C>G	uc002ryv.2	-	29	5611	c.4769G>C	c.(4768-4770)GGC>GCC	p.G1590A	CCDC88A_uc010yoz.1_Missense_Mutation_p.G1563A|CCDC88A_uc010ypa.1_Missense_Mutation_p.G1590A|CCDC88A_uc002ryt.2_5'Flank|CCDC88A_uc010fbw.2_Intron|CCDC88A_uc002ryu.2_Missense_Mutation_p.G845A|CCDC88A_uc002rys.2_Missense_Mutation_p.G548A|CCDC88A_uc002ryw.2_Missense_Mutation_p.G874A|CCDC88A_uc010fby.1_Missense_Mutation_p.G442A	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1591					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GGATGTTCTGCCACTATCAAG	0.378000													63	71					0	0	0.014410	0	0	
FAM161A	84140	broad.mit.edu	37	2	62069423	62069423	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:62069423G>T	uc010ypo.1	-	2	358	c.256C>A	c.(256-258)CCT>ACT	p.P86T	FAM161A_uc002sbm.3_Missense_Mutation_p.P86T|FAM161A_uc002sbn.3_5'UTR|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_5'UTR	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	86					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						TGAATATCAGGAAAGTTCACA	0.408000													3	9					0.004672	0.00477313	0.004672	1	0	
CLEC4F	165530	broad.mit.edu	37	2	71039670	71039670	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:71039670A>G	uc002shf.2	-	5	1525	c.1448T>C	c.(1447-1449)TTT>TCT	p.F483S	CLEC4F_uc010yqv.1_Missense_Mutation_p.F483S	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	483	Extracellular (Potential).|C-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						GACACTAGAAAAATAATATAA	0.522000													35	115					0	0	0.004878	0	0	
ELMOD3	84173	broad.mit.edu	37	2	85584355	85584355	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:85584355G>C	uc002spf.3	+	5	699	c.34G>C	c.(34-36)GAA>CAA	p.E12Q	ELMOD3_uc010fgg.2_RNA|ELMOD3_uc002spg.3_Missense_Mutation_p.E12Q|ELMOD3_uc002sph.3_Missense_Mutation_p.E12Q|ELMOD3_uc010ysn.1_Missense_Mutation_p.E12Q|ELMOD3_uc010yso.1_RNA|ELMOD3_uc010ysp.1_RNA|RETSAT_uc002spd.2_5'Flank|RETSAT_uc010ysm.1_5'Flank|RETSAT_uc010fgf.2_5'Flank	NM_001135021	NP_001128493	Q96FG2	ELMD3_HUMAN	ELMO/CED-12 domain containing 3 isoform b	12					phagocytosis	cytoskeleton				ovary(2)	2						CCATAGTAAAGAAGAATTAAG	0.348000													21	27					0	0	0.014323	0	0	
EIF2AK3	9451	broad.mit.edu	37	2	88874887	88874887	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:88874887G>T	uc002stc.3	-	13	2316	c.2114C>A	c.(2113-2115)ACA>AAA	p.T705K		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	705	Cytoplasmic (Potential).|Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						ATGTTCTTTTGTAGCGAAAGG	0.438000													28	76					3.65163e-15	3.95314e-15	0.006320	1	0	
Unknown	0	broad.mit.edu	37	2	96458242	96458242	+	RNA	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:96458242A>C	uc010yuf.1	+	3		c.260A>C				NM_207328				glycerol-3-phosphate acyltransferase 2,																		TTCCTGGGCAAGTATCGCCCC	0.587000													6	33					0	0	0.001984	0	0	
CNGA3	1261	broad.mit.edu	37	2	98996761	98996761	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:98996761A>G	uc002syt.2	+	4	756	c.339A>G	c.(337-339)CAA>CAG	p.Q113Q	CNGA3_uc002syu.2_Silent_p.Q113Q|CNGA3_uc010fij.2_Silent_p.Q117Q	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	113					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGTCCAGCCAAGAAAGCAATG	0.602000													9	59					0	0	0.004482	0	0	
UXS1	80146	broad.mit.edu	37	2	106781218	106781218	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:106781218G>C	uc002tdm.2	-	3	243	c.145C>G	c.(145-147)CTA>GTA	p.L49V	UXS1_uc002tdn.2_Missense_Mutation_p.L54V|UXS1_uc002tdo.2_Intron|UXS1_uc010ywh.1_Intron	NM_025076	NP_079352	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	49	Lumenal (Potential).				cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2						TCAATTTTTAGTTCACCATTT	0.333000													5	15					0	0	0.001168	0	0	
SLC35F5	80255	broad.mit.edu	37	2	114483031	114483031	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:114483031G>C	uc002tku.1	-	12	1598	c.1174C>G	c.(1174-1176)CCC>GCC	p.P392A	SLC35F5_uc002tkt.2_RNA	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	392					transport	integral to membrane					0						ACTTTATTGGGAAACTCGAAG	0.353000													35	52					0	0	0.003271	0	0	
CNTNAP5	129684	broad.mit.edu	37	2	125262020	125262020	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:125262020T>G	uc002tno.2	+	8	1575	c.1211T>G	c.(1210-1212)CTT>CGT	p.L404R	CNTNAP5_uc010flu.2_Missense_Mutation_p.L405R	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	404	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GATGGTCTGCTTCTGTCCACA	0.552000													18	40					0	0	0.006122	0	0	
NCKAP5	344148	broad.mit.edu	37	2	133489583	133489583	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:133489583T>G	uc002ttp.2	-	17	5544	c.5170A>C	c.(5170-5172)ACC>CCC	p.T1724P	NCKAP5_uc002ttq.2_Missense_Mutation_p.T405P	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1724							protein binding				0						AGTGGAAAGGTTCCGATCCCA	0.527000													16	26					0	0	0.004007	0	0	
THSD7B	80731	broad.mit.edu	37	2	137814006	137814006	+	Silent	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:137814006T>C	uc002tva.1	+	2	63	c.63T>C	c.(61-63)TGT>TGC	p.C21C	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGGGAAGGTGTACAGGAGACT	0.473000													4	66					0	0	0.000602	0	0	
THSD7B	80731	broad.mit.edu	37	2	137852465	137852465	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:137852465C>T	uc002tva.1	+	3	880	c.880C>T	c.(880-882)CCA>TCA	p.P294S	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.P184S	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AGATTCCTTCCCATTGACTGT	0.458000													24	148					0	0	0.003954	0	0	
LRP1B	53353	broad.mit.edu	37	2	141004675	141004675	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:141004675T>G	uc002tvj.1	-	87	14276	c.13304A>C	c.(13303-13305)AAG>ACG	p.K4435T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4435	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGATCAGACTTGCTGCTCTT	0.378000										TSP Lung(27;0.18)			17	19					0	0	0.010504	0	0	
XIRP2	129446	broad.mit.edu	37	2	168106793	168106793	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:168106793T>G	uc002udx.2	+	8	8909	c.8891T>G	c.(8890-8892)TTT>TGT	p.F2964C	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.F2789C|XIRP2_uc010fpq.2_Missense_Mutation_p.F2742C|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.F310C	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2789	Potential.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTGAAACAGTTTGAAGCAGAG	0.378000													4	118					0	0	0.009096	0	0	
DHRS9	10170	broad.mit.edu	37	2	169952128	169952128	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:169952128G>A	uc002uep.2	+	8	2315	c.811G>A	c.(811-813)GCT>ACT	p.A271T	DHRS9_uc002ueq.2_Missense_Mutation_p.A271T|DHRS9_uc010zdc.1_Missense_Mutation_p.A331T|DHRS9_uc010zdd.1_Missense_Mutation_p.A271T|DHRS9_uc010zde.1_Missense_Mutation_p.A271T	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	271					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						CATGGACCACGCTCTAACAAG	0.433000													66	101					0	0	0.014410	0	0	
LRP2	4036	broad.mit.edu	37	2	170038698	170038698	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:170038698A>T	uc002ues.2	-	51	10190	c.9977T>A	c.(9976-9978)CTT>CAT	p.L3326H		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3326	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTGAAGGGCAAGTCCTCTGGG	0.522000													13	84					0	0	0.002450	0	0	
TTN	7273	broad.mit.edu	37	2	179586841	179586841	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:179586841A>C	uc010zfg.1	-	75	19041	c.18817T>G	c.(18817-18819)TTT>GTT	p.F6273V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.F2934V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7200							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGATGTCAAAGAAGGGAGAT	0.383000													29	187					0	0	0.010818	0	0	
TTN	7273	broad.mit.edu	37	2	179595331	179595331	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:179595331C>T	uc010zfg.1	-	58	14421	c.14197G>A	c.(14197-14199)GAA>AAA	p.E4733K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E1394K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5660							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGCTGATTTCCAAGAAGGCA	0.448000													14	106					0	0	0.001855	0	0	
TTN	7273	broad.mit.edu	37	2	179612541	179612541	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:179612541T>G	uc002unb.2	-	46	14810	c.14586A>C	c.(14584-14586)GAA>GAC	p.E4862D	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAACTTGAACTTCTTCATAAC	0.358000													11	55					0	0	0.008291	0	0	
TTN	7273	broad.mit.edu	37	2	179614133	179614133	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:179614133T>G	uc002unb.2	-	46	13218	c.12994A>C	c.(12994-12996)AAA>CAA	p.K4332Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGGAATTTTTTCTCTAGAA	0.398000													15	97					0	0	0.002450	0	0	
TTN	7273	broad.mit.edu	37	2	179644153	179644153	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:179644153T>C	uc010zfg.1	-	23	3990	c.3766A>G	c.(3766-3768)AAA>GAA	p.K1256E	TTN_uc010zfh.1_Missense_Mutation_p.K1210E|TTN_uc010zfi.1_Missense_Mutation_p.K1210E|TTN_uc010zfj.1_Missense_Mutation_p.K1210E|TTN_uc002unb.2_Missense_Mutation_p.K1256E|uc002unc.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1256							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAATTTCTTTAATAAGTCTC	0.289000													8	18					0	0	0.004482	0	0	
GLS	2744	broad.mit.edu	37	2	191796341	191796341	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:191796341G>A	uc002usf.2	+	14	1892	c.1628G>A	c.(1627-1629)CGA>CAA	p.R543Q	GLS_uc002use.2_Missense_Mutation_p.R543Q|GLS_uc002usg.1_Missense_Mutation_p.R204Q|GLS_uc002ush.2_Missense_Mutation_p.R204Q|GLS_uc010zgi.1_Missense_Mutation_p.R114Q|GLS_uc010zgj.1_Missense_Mutation_p.R48Q	NM_014905	NP_055720	O94925	GLSK_HUMAN	glutaminase precursor	543					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTTGATCCTCGAAGAGAAGGT	0.299000													10	61					0	0	0.010729	0	0	
DNAH7	56171	broad.mit.edu	37	2	196762419	196762419	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:196762419A>C	uc002utj.3	-	29	4720	c.4619T>G	c.(4618-4620)TTT>TGT	p.F1540C		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1540					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATGGGATAAAAATTTTGGCAG	0.284000													10	18					0	0	0.008291	0	0	
ZDBF2	57683	broad.mit.edu	37	2	207170929	207170929	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:207170929A>C	uc002vbp.2	+	5	1927	c.1677A>C	c.(1675-1677)GAA>GAC	p.E559D		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	559							nucleic acid binding|zinc ion binding			ovary(3)	3						CTGTCACAGAAACAAAACTTC	0.433000													14	9					0	0	0.002450	0	0	
MAP2	4133	broad.mit.edu	37	2	210558338	210558338	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:210558338T>G	uc002vde.1	+	7	1692	c.1444T>G	c.(1444-1446)TCA>GCA	p.S482A	MAP2_uc002vdc.1_Missense_Mutation_p.S482A|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.S478A	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	482					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GCACACTTTCTCAGAACAGAA	0.443000													4	39					0	0	0.009096	0	0	
PAX3	5077	broad.mit.edu	37	2	223160324	223160324	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:223160324T>G	uc010fwo.2	-	3	740	c.374A>C	c.(373-375)AAC>ACC	p.N125T	PAX3_uc002vmt.1_Missense_Mutation_p.N125T|PAX3_uc002vmy.1_Missense_Mutation_p.N124T|PAX3_uc002vmv.1_Missense_Mutation_p.N125T|PAX3_uc002vmw.1_Missense_Mutation_p.N125T|PAX3_uc002vmx.1_Missense_Mutation_p.N125T|PAX3_uc002vmz.1_Missense_Mutation_p.N125T|PAX3_uc002vna.1_Missense_Mutation_p.N125T|CCDC140_uc002vnb.1_5'Flank	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	125	Paired.				apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.N125K(1)	PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CATGCCCGGGTTCTCTCTTTT	0.537000			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						10	46					0	0	0.008291	0	0	
SCG2	7857	broad.mit.edu	37	2	224462806	224462806	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:224462806A>C	uc002vnm.2	-	2	1328	c.1195T>G	c.(1195-1197)TTA>GTA	p.L399V		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	399					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GGATGGTCTAAGTCAGCCTCT	0.532000													29	29					0	0	0.007291	0	0	
IRS1	3667	broad.mit.edu	37	2	227662033	227662033	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr2:227662033G>A	uc002voh.3	-	1	1474	c.1422C>T	c.(1420-1422)TCC>TCT	p.S474S		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	474					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CGGTCAGGGTGGAGGGCCCCT	0.642000											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	39					0	0	0.014410	0	0	
C20orf194	25943	broad.mit.edu	37	20	3296404	3296404	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:3296404T>C	uc002wii.2	-	19	1619	c.1568A>G	c.(1567-1569)GAG>GGG	p.E523G	C20orf194_uc002wij.3_Missense_Mutation_p.E262G|C20orf194_uc002wik.2_Missense_Mutation_p.E197G	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	523											0						CTGGGTTTTCTCAGACAATTT	0.383000													7	107					0	0	0.001984	0	0	
ANKRD5	63926	broad.mit.edu	37	20	10025099	10025099	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:10025099C>T	uc002wno.2	+	5	997	c.604C>T	c.(604-606)CGA>TGA	p.R202*	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Nonsense_Mutation_p.R202*|ANKRD5_uc010gbz.2_Nonsense_Mutation_p.R13*	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	202	ANK 2.						calcium ion binding			ovary(1)|breast(1)	2						GGAAATAGTTCGAGGCATATT	0.438000													39	127					0	0	0.006230	0	0	
MACROD2	140733	broad.mit.edu	37	20	15866408	15866408	+	Splice_Site	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:15866408G>C	uc002wou.2	+	10	992	c.728_splice	c.e10-1	p.D243_splice	MACROD2_uc002wot.2_Splice_Site_p.D243_splice|MACROD2_uc002woz.2_Splice_Site_p.D8_splice|MACROD2_uc002wpb.2_Splice_Site_p.D8_splice	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1												0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				TTTTTTAACAGACGATAATAA	0.294000													24	149					0	0	0.003954	0	0	
C20orf26	26074	broad.mit.edu	37	20	20278863	20278863	+	Silent	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:20278863T>G	uc002wru.2	+	25	3331	c.3255T>G	c.(3253-3255)ACT>ACG	p.T1085T	C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	1085										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		AAAATGGGACTTACTTCCGAA	0.448000													4	124					0	0	0.009096	0	0	
C20orf3	57136	broad.mit.edu	37	20	24952138	24952138	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:24952138C>A	uc002wty.2	-	5	597	c.496G>T	c.(496-498)GCC>TCC	p.A166S	C20orf3_uc002wtz.2_Missense_Mutation_p.A166S|C20orf3_uc010zsw.1_Missense_Mutation_p.A166S	NM_020531	NP_065392	Q9HDC9	APMAP_HUMAN	chromosome 20 open reading frame 3	166	Extracellular (Potential).				biosynthetic process	cell surface|integral to membrane	arylesterase activity|strictosidine synthase activity			ovary(1)	1						TATGCATCGGCCACAAAGAGA	0.433000													38	127					5.04308e-16	5.48464e-16	0.006230	1	0	
C20orf70	140683	broad.mit.edu	37	20	31763239	31763239	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:31763239T>C	uc002wyo.1	+	5	508	c.437T>C	c.(436-438)CTG>CCG	p.L146P		NM_080574	NP_542141	Q96DR5	SPLC2_HUMAN	chromosome 20 open reading frame 70 precursor	146						extracellular region	lipid binding			ovary(1)|central_nervous_system(1)	2						ATTATCAACCTGAAAGCCTCC	0.542000													13	315					0	0	0.001855	0	0	
GDF5	8200	broad.mit.edu	37	20	34025104	34025104	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:34025104A>G	uc002xck.1	-	1	924	c.605T>C	c.(604-606)ATC>ACC	p.I202T	GDF5_uc010gfc.1_Missense_Mutation_p.I202T|GDF5_uc010zvc.1_Missense_Mutation_p.I202T	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	202					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			AAAGCTGGTGATGGTGTTGGC	0.607000													22	52					0	0	0.014323	0	0	
DLGAP4	22839	broad.mit.edu	37	20	35152740	35152740	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:35152740A>C	uc002xff.2	+	11	3026	c.2591A>C	c.(2590-2592)AAC>ACC	p.N864T	DLGAP4_uc010zvp.1_Missense_Mutation_p.N864T|DLGAP4_uc002xfg.2_Missense_Mutation_p.N160T|DLGAP4_uc002xfh.2_Missense_Mutation_p.N328T|DLGAP4_uc002xfi.2_Missense_Mutation_p.N173T|DLGAP4_uc002xfj.2_Missense_Mutation_p.N160T|uc002xfk.3_Intron	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	867					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				TGTGAGCAAAACTTGGTGAGT	0.557000													5	80					0	0	0.001168	0	0	
CHD6	84181	broad.mit.edu	37	20	40033690	40033690	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:40033690A>G	uc002xka.1	-	37	7869	c.7691T>C	c.(7690-7692)GTG>GCG	p.V2564A	CHD6_uc002xjz.1_Missense_Mutation_p.V101A	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2564					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CTTTTCAGTCACTGCCGTACC	0.517000													88	157					0	0	0.014410	0	0	
IFT52	51098	broad.mit.edu	37	20	42232466	42232466	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:42232466G>C	uc002xkw.2	+	4	396	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	IFT52_uc010zwi.1_Intron|IFT52_uc002xky.2_Missense_Mutation_p.E92Q|IFT52_uc002xkx.2_RNA|IFT52_uc010ggn.2_Missense_Mutation_p.E92Q|IFT52_uc002xkz.2_Missense_Mutation_p.E92Q	NM_016004	NP_057088	Q9Y366	IFT52_HUMAN	intraflagellar transport 52 homolog	92						intraflagellar transport particle B|microtubule-based flagellum	protein C-terminus binding			ovary(2)	2		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AGAAGGTGGAGAATCCAGATT	0.323000													42	89					0	0	0.008740	0	0	
TSHZ2	128553	broad.mit.edu	37	20	51872267	51872267	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:51872267T>G	uc002xwo.2	+	2	3226	c.2270T>G	c.(2269-2271)CTG>CGG	p.L757R		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	757					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AGGCGCTACCTGTTTGAGAAC	0.522000													49	118					0	0	0.014410	0	0	
STX16	8675	broad.mit.edu	37	20	57246276	57246276	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:57246276G>C	uc002xzi.2	+	7	1450	c.715G>C	c.(715-717)GAG>CAG	p.E239Q	STX16_uc010zzq.1_Missense_Mutation_p.E53Q|STX16_uc002xzk.2_Missense_Mutation_p.E222Q|STX16_uc002xzm.2_Missense_Mutation_p.E235Q|STX16_uc002xzj.2_Missense_Mutation_p.E218Q|STX16_uc002xzl.2_Missense_Mutation_p.E53Q	NM_001001433	NP_001001433	O14662	STX16_HUMAN	syntaxin 16 isoform a	239	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			ovary(1)	1	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			GCGGGAACGAGAGATTCGCCA	0.478000													38	130					0	0	0.006230	0	0	
GNAS	2778	broad.mit.edu	37	20	57415578	57415578	+	Silent	SNP	C	T	T	rs148044699		TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:57415578C>T	uc002xzt.2	+	1	784	c.417C>T	c.(415-417)ACC>ACT	p.T139T	GNASAS_uc002xzs.1_Intron|GNAS_uc002xzu.3_5'Flank|GNAS_uc010gjq.2_5'Flank	NM_016592	NP_057676	P63092	GNAS2_HUMAN	GNAS complex locus NESP55	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			AGCCCGAGACCGAGCCTGAAG	0.652000			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			31	128					0	0	0.012213	0	0	
SYCP2	10388	broad.mit.edu	37	20	58467103	58467103	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:58467103T>G	uc002yaz.2	-	23	2445	c.2306A>C	c.(2305-2307)AAA>ACA	p.K769T		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	769					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TTTCTCTGCTTTTCTATGACT	0.333000													4	108					0	0	0.001168	0	0	
CDH26	60437	broad.mit.edu	37	20	58545194	58545194	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:58545194G>A	uc002ybe.2	+	3	484	c.184G>A	c.(184-186)GAG>AAG	p.E62K	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	62	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CACCACCTTGGAGCTGGAGGA	0.507000													39	128					0	0	0.010771	0	0	
PCMTD2	55251	broad.mit.edu	37	20	62891494	62891494	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr20:62891494G>C	uc002yil.3	+	2	376	c.176G>C	c.(175-177)GGA>GCA	p.G59A	PCMTD2_uc002yim.3_Missense_Mutation_p.G59A	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	59						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					TGGAAGCATGGAAACATTCAC	0.488000													49	131					0	0	0.014410	0	0	
NRIP1	8204	broad.mit.edu	37	21	16338789	16338789	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr21:16338789G>C	uc002yjx.2	-	4	2323	c.1725C>G	c.(1723-1725)ATC>ATG	p.I575M		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	575	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		AATTCCATTTGATGACCAGAG	0.453000													123	199					0	0	0.014410	0	0	
TIAM1	7074	broad.mit.edu	37	21	32624154	32624154	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr21:32624154C>T	uc002yow.1	-	6	1787	c.1315G>A	c.(1315-1317)GCC>ACC	p.A439T	TIAM1_uc011adk.1_Missense_Mutation_p.A439T|TIAM1_uc011adl.1_Missense_Mutation_p.A439T|TIAM1_uc002yox.1_Missense_Mutation_p.A47T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	439	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						ACGGCCAGGGCGCCGGCCTTG	0.642000													6	127					0	0	0.001984	0	0	
B3GALT5	10317	broad.mit.edu	37	21	41033300	41033300	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr21:41033300C>T	uc002yyb.1	+	5	1406	c.814C>T	c.(814-816)CGC>TGC	p.R272C	B3GALT5_uc002yye.2_Missense_Mutation_p.R272C|B3GALT5_uc002yyi.1_Missense_Mutation_p.R272C|B3GALT5_uc002yyj.1_Missense_Mutation_p.R272C|B3GALT5_uc002yyk.1_Missense_Mutation_p.R272C|B3GALT5_uc002yyl.1_Missense_Mutation_p.R272C|B3GALT5_uc002yym.1_Missense_Mutation_p.R272C	NM_033173	NP_149363	Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta	272	Lumenal (Potential).				protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1		Prostate(19;2.55e-06)				AGGGGGCTTACGCTTCTCCGT	0.557000													42	72					0	0	0.009718	0	0	
DSCAM	1826	broad.mit.edu	37	21	41414515	41414515	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr21:41414515C>G	uc002yyq.1	-	32	5921	c.5469G>C	c.(5467-5469)ATG>ATC	p.M1823I	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1823	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTTGCTCTTCCATCTTGGCGT	0.532000													32	68					0	0	0.012213	0	0	
TRPM2	7226	broad.mit.edu	37	21	45838438	45838438	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr21:45838438A>C	uc002zet.1	+	23	3674	c.3461A>C	c.(3460-3462)AAG>ACG	p.K1154T	TRPM2_uc002zeu.1_Missense_Mutation_p.K1154T|TRPM2_uc002zew.1_Missense_Mutation_p.K1154T|TRPM2_uc010gpt.1_Missense_Mutation_p.K1154T|TRPM2_uc002zex.1_Missense_Mutation_p.K940T|TRPM2_uc002zey.1_Missense_Mutation_p.K667T|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1154	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ATCAGCAATAAGTATGGGGGC	0.612000													21	161					0	0	0.014323	0	0	
CECR2	27443	broad.mit.edu	37	22	18016838	18016838	+	Silent	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr22:18016838G>C	uc010gqw.1	+	9	1215	c.1089G>C	c.(1087-1089)CTG>CTC	p.L363L	CECR2_uc010gqv.1_Silent_p.L222L|CECR2_uc002zml.2_Silent_p.L222L|CECR2_uc002zmn.2_5'UTR	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	405					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		CATGGCTGCTGGCTCAAGGAA	0.488000													16	44					0	0	0.004007	0	0	
TOP3B	8940	broad.mit.edu	37	22	22313991	22313991	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr22:22313991C>T	uc002zvs.2	-	15	2207	c.1772G>A	c.(1771-1773)AGG>AAG	p.R591K	TOP3B_uc010gtm.1_Missense_Mutation_p.R136K|TOP3B_uc002zvr.2_Missense_Mutation_p.R316K|TOP3B_uc010gtl.2_Missense_Mutation_p.R591K|TOP3B_uc002zvt.3_Missense_Mutation_p.R591K	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	591					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		GTGGAACTTCCTCTTGAACAC	0.612000													74	90					0	0	0.014410	0	0	
LOC96610	96610	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr22:22664141G>A	uc011aim.1	+	30		c.1998G>A			LOC96610_uc011aiq.1_RNA					Parts of antibodies, mostly variable regions.												0						AAATTTGAAGGTGCTGTGATT	0.448000													4	91					0	0	0.009096	0	0	
LOC96610	96610	broad.mit.edu	37	22	23248693	23248693	+	RNA	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr22:23248693A>C	uc011aim.1	+	374		c.16205A>C			uc002zws.2_RNA					Parts of antibodies, mostly variable regions.												0						CCTCCAAACAAAGCAACAACA	0.592000													9	42					0	0	0.008291	0	0	
EWSR1	2130	broad.mit.edu	37	22	29695814	29695814	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr22:29695814G>T	uc003aet.2	+	16	2232	c.1904G>T	c.(1903-1905)GGA>GTA	p.G635V	EWSR1_uc003aev.2_Missense_Mutation_p.G640V|EWSR1_uc003aew.2_Missense_Mutation_p.G579V|EWSR1_uc003aex.2_Missense_Mutation_p.G634V|EWSR1_uc003aey.2_Missense_Mutation_p.G430V|EWSR1_uc003aez.2_Missense_Mutation_p.G296V	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	635	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						AGAAGAGGAGGACGTGGAGGA	0.607000			T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								3	13					0.004672	0.00477313	0.004672	1	0	
NEFH	4744	broad.mit.edu	37	22	29885713	29885713	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr22:29885713A>T	uc003afo.2	+	4	2155	c.2084A>T	c.(2083-2085)AAG>ATG	p.K695M	NEFH_uc003afp.2_Translation_Start_Site	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	701	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.|20.				cell death|nervous system development	neurofilament					0						GAGAAGGCCAAGTCCCCAGTG	0.562000													7	188					0	0	0.003080	0	0	
KCNJ4	3761	broad.mit.edu	37	22	38823739	38823739	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr22:38823739C>T	uc003avs.1	-	2	496	c.399G>A	c.(397-399)ACG>ACA	p.T133T	KCNJ4_uc003avt.1_Silent_p.T133T	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	133					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					AGCCGATGGTCGTCTGCGTCT	0.622000													39	41					0	0	0.007835	0	0	
SATB1	6304	broad.mit.edu	37	3	18427901	18427901	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:18427901C>T	uc003cbh.2	-	8	3144	c.1409G>A	c.(1408-1410)CGT>CAT	p.R470H	SATB1_uc003cbi.2_Missense_Mutation_p.R470H|SATB1_uc003cbj.2_Missense_Mutation_p.R470H	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	470					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						CTGGGGAGGACGGCTGGGTGG	0.488000													10	80					0	0	0.008291	0	0	
KCNH8	131096	broad.mit.edu	37	3	19498345	19498345	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:19498345T>G	uc003cbk.1	+	11	2106	c.1911T>G	c.(1909-1911)TGT>TGG	p.C637W	KCNH8_uc010hex.1_Missense_Mutation_p.C98W	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	637	cNMP.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TAACCTACTGTGATCTCCAGT	0.408000													11	27					0	0	0.008291	0	0	
SCN5A	6331	broad.mit.edu	37	3	38616871	38616871	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:38616871G>A	uc003cio.2	-	20	3777	c.3583C>T	c.(3583-3585)CGC>TGC	p.R1195C	SCN5A_uc003cin.2_Missense_Mutation_p.R1194C|SCN5A_uc003cil.3_Missense_Mutation_p.R1195C|SCN5A_uc010hhi.2_Missense_Mutation_p.R1195C|SCN5A_uc010hhk.2_Missense_Mutation_p.R1194C|SCN5A_uc011ayr.1_Missense_Mutation_p.R1141C|SCN5A_uc010hhj.1_Missense_Mutation_p.R805C	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1195					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CAGGTCTTGCGCAACCGCCAC	0.612000													12	3					0	0	0.010729	0	0	
DOCK3	1795	broad.mit.edu	37	3	50971428	50971428	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:50971428G>T	uc011bds.1	+	5	258	c.235G>T	c.(235-237)GTT>TTT	p.V79F		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	79						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGAAACTGTGGTTCCACTTGA	0.398000													14	6					1.52009e-12	1.63064e-12	0.003163	1	0	
ACTR8	93973	broad.mit.edu	37	3	53906522	53906522	+	Silent	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:53906522A>C	uc003dhd.2	-	10	1250	c.1191T>G	c.(1189-1191)ACT>ACG	p.T397T	ACTR8_uc003dhb.2_Silent_p.T102T|ACTR8_uc003dhc.2_Silent_p.T286T	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	397					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding	p.T397I(1)		ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		CGATTCCAAAAGTTGCGGGGT	0.443000													43	105					0	0	0.010771	0	0	
ERC2	26059	broad.mit.edu	37	3	56183132	56183132	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:56183132T>G	uc003dhr.1	-	5	1434	c.1178A>C	c.(1177-1179)AAC>ACC	p.N393T		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	393	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		ATCCCTTATGTTTCGTTCCAA	0.328000													9	28					0	0	0.006214	0	0	
SLC15A2	6565	broad.mit.edu	37	3	121641917	121641917	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:121641917A>C	uc003eep.2	+	10	1051	c.898A>C	c.(898-900)ACC>CCC	p.T300P	SLC15A2_uc011bjn.1_Missense_Mutation_p.T269P	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	300	Helical; (Potential).				protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	AAAGGCACTGACCAGGGTACT	0.433000													11	149					0	0	0.010729	0	0	
SEMA5B	54437	broad.mit.edu	37	3	122629130	122629130	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:122629130A>G	uc003efz.1	-	23	3620	c.3316T>C	c.(3316-3318)TTG>CTG	p.L1106L	SEMA5B_uc011bju.1_Silent_p.L1012L|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003efy.1_Silent_p.L84L	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	1106	Cytoplasmic (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TCAGGGATCAAGTTATTCTTG	0.527000													27	35					0	0	0.006320	0	0	
MYLK	4638	broad.mit.edu	37	3	123383036	123383036	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:123383036G>A	uc003ego.2	-	23	4183	c.3901C>T	c.(3901-3903)CGC>TGC	p.R1301C	MYLK_uc010hrr.2_5'UTR|MYLK_uc011bjv.1_Missense_Mutation_p.R101C|MYLK_uc011bjw.1_Missense_Mutation_p.R1301C|MYLK_uc003egp.2_Missense_Mutation_p.R1232C|MYLK_uc003egq.2_Missense_Mutation_p.R1301C|MYLK_uc003egr.2_Missense_Mutation_p.R1232C|MYLK_uc003egs.2_Missense_Mutation_p.R1125C	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1301	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGCTCCTGGCGCGCGGCCAGG	0.627000													20	113					0	0	0.003330	0	0	
MFSD1	64747	broad.mit.edu	37	3	158538076	158538076	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:158538076G>A	uc003fcl.1	+	9	854	c.824G>A	c.(823-825)TGC>TAC	p.C275Y	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_Missense_Mutation_p.C178Y|MFSD1_uc011bow.1_Missense_Mutation_p.C236Y|MFSD1_uc011box.1_Missense_Mutation_p.C202Y	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	275	Helical; (Potential).			C -> R (in Ref. 1; BAB20269).	transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ATCTGTGTCTGCTATTATGTT	0.348000													77	25					0	0	0.014410	0	0	
EIF4G1	1981	broad.mit.edu	37	3	184049780	184049780	+	Silent	SNP	G	A	A	rs112264710	byFrequency	TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr3:184049780G>A	uc003fnp.2	+	32	4722	c.4524G>A	c.(4522-4524)GCG>GCA	p.A1508A	EIF4G1_uc003fnt.2_Silent_p.A1219A|EIF4G1_uc003fnq.2_Silent_p.A1421A|EIF4G1_uc003fnr.2_Silent_p.A1344A|EIF4G1_uc010hxx.2_Silent_p.A1515A|EIF4G1_uc003fns.2_Silent_p.A1468A|EIF4G1_uc010hxy.2_Silent_p.A1515A|EIF4G1_uc003fnv.3_Silent_p.A1509A|EIF4G1_uc003fnu.3_Silent_p.A1508A|EIF4G1_uc003fnw.2_Silent_p.A1515A|EIF4G1_uc003fnx.2_Silent_p.A1313A|EIF4G1_uc003fny.3_Silent_p.A1312A|EIF4G1_uc003foa.2_Silent_p.A180A	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1508	W2.|EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AAGCGCGAGCGAAGCTGCTGC	0.547000													8	56					0	0	0.003080	0	0	
SH3TC1	54436	broad.mit.edu	37	4	8233834	8233834	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:8233834C>T	uc003gkv.3	+	13	3183	c.3082C>T	c.(3082-3084)CAG>TAG	p.Q1028*	SH3TC1_uc003gkw.3_Nonsense_Mutation_p.Q952*|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	1028	TPR 7.						binding			large_intestine(2)|pancreas(1)	3						GCTGGAGGGGCAGCTCCTGGA	0.532000													6	24					0	0	0.001984	0	0	
KCNIP4	80333	broad.mit.edu	37	4	20751288	20751288	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:20751288G>A	uc003gqe.2	-	4	459	c.375C>T	c.(373-375)TTC>TTT	p.F125F	KCNIP4_uc003gqf.1_Silent_p.F121F|KCNIP4_uc003gqg.1_Silent_p.F80F|KCNIP4_uc003gqh.1_Silent_p.F117F|KCNIP4_uc003gqi.1_Silent_p.F80F|PACRGL_uc003gpu.2_Intron|PACRGL_uc003gpx.3_Intron|PACRGL_uc003gpw.2_Intron|KCNIP4_uc010iel.2_Silent_p.F122F|KCNIP4_uc003gqd.3_Silent_p.F105F	NM_147182	NP_671711	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 3	142	EF-hand 2.|1 (Potential).					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				AGCTTACCTCGAAACTCACAG	0.358000													5	8					0	0	0.001984	0	0	
OCIAD1	54940	broad.mit.edu	37	4	48853965	48853965	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:48853965A>G	uc003gyo.2	+	7	777	c.520A>G	c.(520-522)ACT>GCT	p.T174A	OCIAD1_uc011bzk.1_RNA|OCIAD1_uc003gyr.2_Missense_Mutation_p.T174A|OCIAD1_uc003gyp.2_Missense_Mutation_p.T174A|OCIAD1_uc003gys.2_Missense_Mutation_p.T174A|OCIAD1_uc003gyq.2_Missense_Mutation_p.T174A|OCIAD1_uc010igk.2_Missense_Mutation_p.T179A	NM_017830	NP_060300	Q9NX40	OCAD1_HUMAN	OCIA domain containing 1 isoform 1	174						endosome	protein binding				0						ATCTGCTCCCACTGGTATTAC	0.358000													38	41					0	0	0.006999	0	0	
AASDH	132949	broad.mit.edu	37	4	57221402	57221402	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:57221402G>A	uc003hbn.2	-	6	1202	c.1049C>T	c.(1048-1050)TCA>TTA	p.S350L	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Missense_Mutation_p.S197L|AASDH_uc003hbo.2_Missense_Mutation_p.S250L|AASDH_uc011cab.1_5'UTR|AASDH_uc010ihc.2_Missense_Mutation_p.S350L|AASDH_uc003hbp.2_Missense_Mutation_p.S350L	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	350					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				CGCCCAACTTGATACCTCTGT	0.378000													8	27					0	0	0.003080	0	0	
EPHA5	2044	broad.mit.edu	37	4	66356240	66356240	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:66356240G>A	uc003hcy.2	-	5	1450	c.1257C>T	c.(1255-1257)AGC>AGT	p.S419S	EPHA5_uc003hcx.2_Silent_p.S350S|EPHA5_uc003hcz.2_Silent_p.S419S|EPHA5_uc011cah.1_Silent_p.S419S|EPHA5_uc011cai.1_Silent_p.S419S|EPHA5_uc003hda.2_Silent_p.S419S	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	419	Fibronectin type-III 1.|Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TTTTCAGGCCGCTTTGCCGGG	0.502000										TSP Lung(17;0.13)			24	23					0	0	0.003954	0	0	
CENPC1	1060	broad.mit.edu	37	4	68383923	68383923	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:68383923T>A	uc003hdd.1	-	7	964	c.781A>T	c.(781-783)AGT>TGT	p.S261C	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihm.1_Missense_Mutation_p.S261C	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	261	Nuclear localization signal (Potential).				mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2						GTTGAAAAACTTTTTTTAGCT	0.313000													5	7					0	0	0.001168	0	0	
TMPRSS11B	132724	broad.mit.edu	37	4	69101927	69101927	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:69101927T>G	uc003hdw.3	-	3	318	c.182A>C	c.(181-183)AAT>ACT	p.N61T		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	61	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GTTTTCACAATTATCATTGTA	0.279000													5	17					0	0	0.001984	0	0	
KLHL8	57563	broad.mit.edu	37	4	88104378	88104378	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:88104378G>A	uc011cdb.1	-	4	1314	c.929C>T	c.(928-930)ACT>ATT	p.T310I	KLHL8_uc003hql.1_Missense_Mutation_p.T310I|KLHL8_uc003hqm.1_Missense_Mutation_p.T234I|KLHL8_uc003hqn.1_Missense_Mutation_p.T127I|KLHL8_uc010ikj.1_Intron	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	310											0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		CCTTGGGGTAGTCCGAATGGA	0.393000													7	52					0	0	0.001984	0	0	
INTU	27152	broad.mit.edu	37	4	128627894	128627894	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:128627894C>A	uc003ifk.1	+	12	2111	c.2041C>A	c.(2041-2043)CAA>AAA	p.Q681K	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	681										ovary(1)	1						CAGTAGGCTACAAGGTACTTC	0.453000													46	32					1.15505e-17	1.25908e-17	0.009718	1	0	
PCDH18	54510	broad.mit.edu	37	4	138451451	138451451	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:138451451A>C	uc003ihe.3	-	1	2179	c.1792T>G	c.(1792-1794)TTT>GTT	p.F598V	PCDH18_uc003ihf.3_Missense_Mutation_p.F591V|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.F378V|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	598	Cadherin 6.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GTGACATGAAAGCCACTTTCA	0.443000													12	129					0	0	0.010729	0	0	
F11	2160	broad.mit.edu	37	4	187197505	187197505	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr4:187197505T>G	uc003iza.1	+	7	1049	c.716T>G	c.(715-717)TTT>TGT	p.F239C		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	239	Apple 3.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	TGCTTGTTTTTTACCTTCTTT	0.418000													3	35					0	0	0.004672	0	0	
CEP72	55722	broad.mit.edu	37	5	620252	620252	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:620252A>C	uc003jbf.2	+	3	351	c.279A>C	c.(277-279)GAA>GAC	p.E93D	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	93	LRR 3.				G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			CGTTGGCAGAAGTGTTTCGGC	0.512000													8	68					0	0	0.003080	0	0	
ADCY2	108	broad.mit.edu	37	5	7820785	7820785	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:7820785G>T	uc003jdz.1	+	24	3173	c.3106G>T	c.(3106-3108)GTC>TTC	p.V1036F	ADCY2_uc011cmo.1_Missense_Mutation_p.V856F|ADCY2_uc010itm.1_Missense_Mutation_p.V232F	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	1036	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CAGCACCGGAGTCCTGGACAA	0.473000													27	39					2.61193e-14	2.81468e-14	0.009535	1	0	
CDH9	1007	broad.mit.edu	37	5	26886151	26886151	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:26886151G>A	uc003jgs.1	-	10	1723	c.1554C>T	c.(1552-1554)CCC>CCT	p.P518P	CDH9_uc011cnv.1_Silent_p.P111P	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	518	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TGTGACCTCGGGGAGGGTCAT	0.323000													8	163					0	0	0.006214	0	0	
RAI14	26064	broad.mit.edu	37	5	34796122	34796122	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:34796122A>C	uc003jir.2	+	4	442	c.246A>C	c.(244-246)CAA>CAC	p.Q82H	RAI14_uc010iur.2_Missense_Mutation_p.Q82H|RAI14_uc011coj.1_Missense_Mutation_p.Q82H|RAI14_uc010ius.1_Missense_Mutation_p.Q11H|RAI14_uc003jis.2_Missense_Mutation_p.Q85H|RAI14_uc003jit.2_Missense_Mutation_p.Q82H|RAI14_uc011cok.1_Missense_Mutation_p.Q74H	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	82						cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					TGACAGCCCAAGATACTACCG	0.398000													8	157					0	0	0.004482	0	0	
DNAJC21	134218	broad.mit.edu	37	5	34941212	34941212	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:34941212G>A	uc003jjc.2	+	7	1134	c.907G>A	c.(907-909)GAT>AAT	p.D303N	DNAJC21_uc003jjb.2_Missense_Mutation_p.D303N|DNAJC21_uc010iuu.1_Missense_Mutation_p.D187N	NM_001012339	NP_001012339	Q5F1R6	DJC21_HUMAN	DnaJ homology subfamily A member 5 isoform 2	303	Glu-rich.				protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|skin(1)	2	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			TAAAGACAGTGATGAGGCCGA	0.358000													25	54					0	0	0.005443	0	0	
LMBRD2	92255	broad.mit.edu	37	5	36116613	36116613	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:36116613T>C	uc003jkb.1	-	11	1800	c.1385A>G	c.(1384-1386)TAT>TGT	p.Y462C		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	462	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGAGGCCAAATAATAATAGTT	0.353000													3	68					0	0	0.004672	0	0	
LIFR	3977	broad.mit.edu	37	5	38490328	38490328	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:38490328A>G	uc010ive.1	-	15	2463	c.2131T>C	c.(2131-2133)TTA>CTA	p.L711L	LIFR_uc003jli.2_Silent_p.L711L	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	711	Fibronectin type-III 5.|Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					GAGCGTAATAATTGATATCCT	0.313000			T	PLAG1	salivary adenoma								38	75					0	0	0.014410	0	0	
RICTOR	253260	broad.mit.edu	37	5	39002699	39002699	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:39002699G>A	uc003jlp.2	-	5	354	c.330C>T	c.(328-330)CTC>CTT	p.L110L	RICTOR_uc003jlo.2_Silent_p.L110L|RICTOR_uc010ivf.2_5'UTR|RICTOR_uc003jlq.1_Silent_p.L94L|RICTOR_uc011cpk.1_Silent_p.L110L	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	110					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					AGTCTTGGATGAGATATCGAA	0.348000													57	106					0	0	0.014410	0	0	
NNT	23530	broad.mit.edu	37	5	43619206	43619206	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:43619206A>C	uc003joe.2	+	5	927	c.672A>C	c.(670-672)AAA>AAC	p.K224N	NNT_uc003jof.2_Missense_Mutation_p.K224N	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	224	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	CTGCTGGAAAAGTTCCTCCAG	0.289000													5	37					0	0	0.003080	0	0	
SNCAIP	9627	broad.mit.edu	37	5	121780267	121780267	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:121780267G>A	uc003ksw.1	+	8	1638	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	SNCAIP_uc011cwl.1_Missense_Mutation_p.E36K|SNCAIP_uc003ksx.1_Missense_Mutation_p.E525K|SNCAIP_uc003ksy.1_Missense_Mutation_p.E112K|SNCAIP_uc003ksz.1_Missense_Mutation_p.E112K|SNCAIP_uc010jcu.2_Missense_Mutation_p.E74K|SNCAIP_uc011cwm.1_Missense_Mutation_p.E112K|SNCAIP_uc003kta.1_Missense_Mutation_p.E110K|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.E172K|SNCAIP_uc010jcx.1_Missense_Mutation_p.E418K|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_5'UTR	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	478	ANK 4.				cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GACCTTGGTTGAATATGGAGC	0.478000													22	107					0	0	0.002780	0	0	
SLC27A6	28965	broad.mit.edu	37	5	128320858	128320858	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:128320858A>T	uc003kuy.2	+	3	910	c.514A>T	c.(514-516)AGC>TGC	p.S172C	SLC27A6_uc003kuz.2_Missense_Mutation_p.S172C	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	172					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AATCCTTCCAAGCCTCTCAGA	0.413000													6	33					0	0	0.001168	0	0	
PCDHA7	56141	broad.mit.edu	37	5	140216062	140216062	+	Silent	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:140216062G>T	uc003lhq.2	+	1	2094	c.2094G>T	c.(2092-2094)GTG>GTT	p.V698V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.V698V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	698	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTCAACGTGTACCTGATCA	0.632000													10	122					2.17888e-05	2.27027e-05	0.006214	1	0	
PCDHA8	56140	broad.mit.edu	37	5	140221014	140221014	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:140221014C>T	uc003lhs.2	+	1	108	c.108C>T	c.(106-108)CCC>CCT	p.P36P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.P36P	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	36	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTCCGTCCCCGAGGAGGCCA	0.667000													5	94					0	0	0.000602	0	0	
PCDHB7	56129	broad.mit.edu	37	5	140554036	140554036	+	Silent	SNP	G	A	A	rs17844465		TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:140554036G>A	uc003lit.2	+	1	1794	c.1620G>A	c.(1618-1620)GCG>GCA	p.A540A		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	540	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCCCCCGCGCTGAGCAGCG	0.701000													41	64					0	0	0.007835	0	0	
PCDHB8	56128	broad.mit.edu	37	5	140559856	140559856	+	Silent	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:140559856T>C	uc011dai.1	+	1	2427	c.2241T>C	c.(2239-2241)TCT>TCC	p.S747S	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	747	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGCCTGTCTCAGAACTATC	0.582000													28	158					0	0	0.005443	0	0	
PCDHB12	56124	broad.mit.edu	37	5	140588829	140588829	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:140588829T>A	uc003liz.2	+	1	539	c.350T>A	c.(349-351)TTA>TAA	p.L117*	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	117	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGCAGTTTTTACAAATTGAG	0.448000													63	93					0	0	0.014410	0	0	
PCDHGA4	56111	broad.mit.edu	37	5	140734980	140734980	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:140734980G>A	uc003ljq.1	+	1	213	c.213G>A	c.(211-213)AGG>AGA	p.R71R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.R71R	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	71	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGAGGTAGGACGCAGCTTT	0.637000													7	132					0	0	0.003080	0	0	
KCTD16	57528	broad.mit.edu	37	5	143586929	143586929	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:143586929G>A	uc003lnm.1	+	3	1281	c.652G>A	c.(652-654)GCC>ACC	p.A218T	KCTD16_uc003lnn.1_Missense_Mutation_p.A218T	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	218						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			CCCTGATCGAGCCCCAGAAAG	0.443000													6	52					0	0	0.001984	0	0	
ADAM19	8728	broad.mit.edu	37	5	156918907	156918907	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:156918907C>T	uc003lwz.2	-	17	1986	c.1922G>A	c.(1921-1923)GGG>GAG	p.G641E	ADAM19_uc003lww.1_Missense_Mutation_p.G374E|ADAM19_uc003lwy.2_Missense_Mutation_p.G240E|ADAM19_uc011ddr.1_Missense_Mutation_p.G572E	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	641	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTGCACTGCCCCTCAAAGCA	0.517000													6	31					0	0	0.003080	0	0	
GABRA1	2554	broad.mit.edu	37	5	161322838	161322838	+	Silent	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:161322838T>G	uc010jiw.2	+	10	1491	c.1023T>G	c.(1021-1023)GGT>GGG	p.G341G	GABRA1_uc010jix.2_Silent_p.G341G|GABRA1_uc010jiy.2_Silent_p.G341G|GABRA1_uc003lyx.3_Silent_p.G341G|GABRA1_uc010jiz.2_Silent_p.G341G|GABRA1_uc010jja.2_Silent_p.G341G|GABRA1_uc010jjb.2_Silent_p.G341G	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	341	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CTAAGAGAGGTTATGCATGGG	0.383000													7	88					0	0	0.004482	0	0	
ZNF354C	30832	broad.mit.edu	37	5	178505938	178505938	+	Silent	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:178505938T>C	uc003mju.2	+	5	620	c.505T>C	c.(505-507)TTA>CTA	p.L169L		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		GGGGAAAAGCTTATTTACAAA	0.343000													7	99					0	0	0.006214	0	0	
FAM65B	9750	broad.mit.edu	37	6	24873165	24873165	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:24873165T>C	uc003neo.1	-	4	456	c.280A>G	c.(280-282)ACG>GCG	p.T94A	FAM65B_uc011djs.1_Missense_Mutation_p.T123A|FAM65B_uc011dju.1_Missense_Mutation_p.T128A|FAM65B_uc003nep.2_Missense_Mutation_p.T94A|FAM65B_uc011djt.1_Missense_Mutation_p.T94A	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	94	Potential.|Involved in cell filopodia formation.				cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						TCCAGCTCCGTCTGGTGAACC	0.408000													31	15					0	0	0.003271	0	0	
BAT2	7916	broad.mit.edu	37	6	31591675	31591675	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:31591675C>T	uc003nvb.3	+	3	528	c.279C>T	c.(277-279)TCC>TCT	p.S93S	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Silent_p.S93S|BAT2_uc003nve.2_5'Flank	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	93	4 X 57 AA type A repeats.|1-1.					cytoplasm|nucleus	protein binding				0						AGGAGCAGTCCGACCCCAAGA	0.522000													180	53					0	0	0.014410	0	0	
VARS	7407	broad.mit.edu	37	6	31750409	31750409	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:31750409C>T	uc003nxe.2	-	16	2312	c.1889G>A	c.(1888-1890)GGC>GAC	p.G630D	VARS_uc003nxf.1_5'Flank|VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	630					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	CCTGGGCAGGCCCTGGGTAGG	0.637000													5	167					0	0	0.000602	0	0	
DNAH8	1769	broad.mit.edu	37	6	38783350	38783350	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:38783350G>A	uc003ooe.1	+	24	3389	c.2789G>A	c.(2788-2790)CGT>CAT	p.R930H		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAGCAAATCCGTCCCATCAAG	0.463000													6	24					0	0	0.001168	0	0	
C6orf138	442213	broad.mit.edu	37	6	47846507	47846507	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:47846507G>A	uc011dwm.1	-	3	2107	c.2022C>T	c.(2020-2022)AGC>AGT	p.S674S	C6orf138_uc011dwn.1_Silent_p.S438S	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	691	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						TTGAGGTGACGCTAAGAATTA	0.453000													23	37					0	0	0.003330	0	0	
TFAP2D	83741	broad.mit.edu	37	6	50712857	50712857	+	Silent	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:50712857T>C	uc003paf.2	+	6	1433	c.921T>C	c.(919-921)ACT>ACC	p.T307T	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	307	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					TTGGCTACACTTGTGAAACAG	0.443000													3	49					0	0	0.004672	0	0	
DST	667	broad.mit.edu	37	6	56504281	56504281	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:56504281G>A	uc003pdf.2	-	20	2755	c.2727C>T	c.(2725-2727)AAC>AAT	p.N909N	DST_uc003pcz.3_Silent_p.N731N|DST_uc011dxj.1_Silent_p.N760N|DST_uc011dxk.1_Silent_p.N771N|DST_uc011dxl.1_Silent_p.N760N|DST_uc003pcy.3_Silent_p.N405N|DST_uc003pdb.2_Silent_p.N405N|DST_uc003pdc.3_Silent_p.N405N|DST_uc003pdd.3_Silent_p.N405N|DST_uc003pde.2_Silent_p.N847N	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	731	Spectrin 1.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTATGTTGGTGTTTCTCTCAC	0.348000													39	93					0	0	0.008740	0	0	
COL12A1	1303	broad.mit.edu	37	6	75799948	75799948	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:75799948T>C	uc003phs.2	-	63	8985	c.8819A>G	c.(8818-8820)CAG>CGG	p.Q2940R	COL12A1_uc003pht.2_Missense_Mutation_p.Q1776R	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2940	Nonhelical region (NC2).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CGGGCCTGGCTGGTTGCGACT	0.572000													14	325					0	0	0.004990	0	0	
PGM3	5238	broad.mit.edu	37	6	83889610	83889610	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:83889610A>G	uc003pjv.2	-	7	904	c.864T>C	c.(862-864)GAT>GAC	p.D288D	PGM3_uc003pjw.2_Silent_p.D207D|PGM3_uc011dyz.1_Silent_p.D316D	NM_015599	NP_056414	O95394	AGM1_HUMAN	phosphoglucomutase 3	288					dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity				0		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)		GGCCATCTGCATCATGGTAGT	0.408000													9	66					0	0	0.006214	0	0	
MDN1	23195	broad.mit.edu	37	6	90405430	90405430	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:90405430C>T	uc003pnn.1	-	61	9781	c.9665G>A	c.(9664-9666)AGC>AAC	p.S3222N		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3222					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CACCCAGAGGCTCCCACGCTG	0.592000													9	61					0	0	0.006214	0	0	
BEND3	57673	broad.mit.edu	37	6	107390518	107390518	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:107390518T>G	uc003prs.2	-	5	2527	c.1877A>C	c.(1876-1878)AAA>ACA	p.K626T		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	626	BEN 3.									ovary(3)	3						GCGGTCGTTTTTGGCGCGTGG	0.642000													3	28					0	0	0.009096	0	0	
RWDD1	51389	broad.mit.edu	37	6	116911490	116911490	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:116911490A>C	uc003pxd.2	+	5	633	c.470A>C	c.(469-471)AAG>ACG	p.K157T	RWDD1_uc003pxb.2_Missense_Mutation_p.K61T|RWDD1_uc003pxc.2_Missense_Mutation_p.K61T	NM_015952	NP_057036	Q9H446	RWDD1_HUMAN	RWD domain containing 1 isoform a	157	Interaction with DRG2 (By similarity).						protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		TGGAAAGCCAAGTTTGATGCA	0.328000													5	55					0	0	0.001168	0	0	
ROS1	6098	broad.mit.edu	37	6	117632217	117632217	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:117632217A>C	uc003pxp.1	-	39	6398	c.6199T>G	c.(6199-6201)TGT>GGT	p.C2067G	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2067	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AAGTAGACACAGCCTTTTGAA	0.383000			T	GOPC|ROS1	glioblastoma|NSCLC								9	83					0	0	0.010729	0	0	
C6orf58	352999	broad.mit.edu	37	6	127911272	127911272	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:127911272A>C	uc003qbh.2	+	5	727	c.715A>C	c.(715-717)AGT>CGT	p.S239R		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	239						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		TTTTGAGAGAAGTTGGGTACT	0.373000													73	15					0	0	0.014410	0	0	
LAMA2	3908	broad.mit.edu	37	6	129636643	129636644	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:129636643_129636644CC>AT	uc003qbn.2	+	25	3683_3684	c.3578_3579CC>AT	c.(3577-3579)ACC>AAT	p.T1193N	LAMA2_uc003qbo.2_Missense_Mutation_p.T1193N	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1193	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCTGAGCAGACCATTCTACCCC	0.470000													4	82					0	0	0.004672	0	0	
OLIG3	167826	broad.mit.edu	37	6	137814944	137814944	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:137814944A>T	uc003qhp.1	-	1	588	c.364T>A	c.(364-366)TCC>ACC	p.S122T		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	122	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GCGATCTTGGAGAGCTTGCGC	0.617000													7	83					0	0	0.001984	0	0	
SYNE1	23345	broad.mit.edu	37	6	152603109	152603109	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:152603109A>C	uc010kiw.2	-	97	18816	c.18214T>G	c.(18214-18216)TTG>GTG	p.L6072V	SYNE1_uc010kiv.2_Missense_Mutation_p.L596V|SYNE1_uc003qos.3_Missense_Mutation_p.L596V|SYNE1_uc003qot.3_Missense_Mutation_p.L6001V|SYNE1_uc003qou.3_Missense_Mutation_p.L6072V|SYNE1_uc010kiy.1_Missense_Mutation_p.L251V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6072	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGATCATTCAACTTCTCCTGT	0.403000										HNSCC(10;0.0054)			27	11					0	0	0.006320	0	0	
TTLL2	83887	broad.mit.edu	37	6	167754541	167754541	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr6:167754541T>G	uc003qvs.1	+	3	1241	c.1153T>G	c.(1153-1155)TTA>GTA	p.L385V	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	385	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ACCATGGCTTTTAGAGGTCAA	0.413000													24	188					0	0	0.003330	0	0	
DNAH11	8701	broad.mit.edu	37	7	21631031	21631031	+	Nonsense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:21631031A>T	uc003svc.2	+	14	2534	c.2503A>T	c.(2503-2505)AAG>TAG	p.K835*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	835	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GAAAAACGTGAAGGTGATCCA	0.602000									Kartagener_syndrome				16	49					0	0	0.004007	0	0	
CCDC129	223075	broad.mit.edu	37	7	31690791	31690791	+	Silent	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:31690791A>T	uc003tcj.1	+	12	3612	c.2619A>T	c.(2617-2619)ATA>ATT	p.I873I	CCDC129_uc011kad.1_Silent_p.I883I|CCDC129_uc003tci.1_Silent_p.I724I|CCDC129_uc011kae.1_Silent_p.I899I|CCDC129_uc003tck.1_Silent_p.I781I	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	873											0						TGAAGACGATATGCCAAAGTT	0.463000													51	73					0	0	0.014410	0	0	
POU6F2	11281	broad.mit.edu	37	7	39247145	39247145	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:39247145T>C	uc003thb.1	+	4	479	c.437T>C	c.(436-438)CTC>CCC	p.L146P	POU6F2_uc010kxo.2_Missense_Mutation_p.L138P	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	146					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						ACAGCGAATCTCACCAACATC	0.567000													7	89					0	0	0.001984	0	0	
IGFBP3	3486	broad.mit.edu	37	7	45956889	45956889	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:45956889G>A	uc003tns.2	-	2	685	c.553C>T	c.(553-555)CGC>TGC	p.R185C	IGFBP3_uc003tnq.2_RNA|IGFBP3_uc003tnr.2_Missense_Mutation_p.R191C|IGFBP3_uc003tnt.2_Missense_Mutation_p.R88C	NM_000598	NP_000589	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	185					negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(2)|lung(1)	3					Mecasermin(DB01277)	ACTTTGTAGCGCTGGCTGTCT	0.507000											OREG0018049	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	93	97					0	0	0.014410	0	0	
HUS1	3364	broad.mit.edu	37	7	48018032	48018032	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:48018032G>A	uc003tod.1	-	3	469	c.339C>T	c.(337-339)CTC>CTT	p.L113L	HUS1_uc003toe.1_Silent_p.L113L|HUS1_uc011kce.1_RNA	NM_004507	NP_004498	O60921	HUS1_HUMAN	HUS1 checkpoint protein	113					DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			ovary(2)|lung(2)|kidney(1)	5		Breast(660;0.00139)				CGGAGACCGTGAGGCAGGGAA	0.448000								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					4	84					0	0	0.009096	0	0	
PSPH	5723	broad.mit.edu	37	7	56087373	56087373	+	Silent	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:56087373G>C	uc003trg.2	-	4	558	c.195C>G	c.(193-195)CGC>CGG	p.R65R	PSPH_uc003trh.2_Silent_p.R65R|PSPH_uc003tri.2_Silent_p.R65R|PSPH_uc003trj.2_Silent_p.R94R	NM_004577	NP_004568	P78330	SERB_HUMAN	phosphoserine phosphatase	65		Substrate.		R->A,K: Loss of activity.	L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGAGGGCTAAGCGCTCTGTGA	0.632000													22	25					0	0	0.002780	0	0	
ZNF273	10793	broad.mit.edu	37	7	64388278	64388278	+	Nonsense_Mutation	SNP	C	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:64388278C>G	uc003tto.2	+	4	648	c.572C>G	c.(571-573)TCA>TGA	p.S191*	ZNF273_uc003ttl.2_Nonsense_Mutation_p.S126*|ZNF273_uc003ttn.2_Nonsense_Mutation_p.S126*	NM_021148	NP_066971	Q14593	ZN273_HUMAN	zinc finger protein 273	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(55;0.0295)|all_lung(88;0.0691)				CATAAATTCTCAAATTCAAAT	0.308000													32	47					0	0	0.013726	0	0	
SEMA3A	10371	broad.mit.edu	37	7	83631275	83631275	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:83631275A>C	uc003uhz.2	-	12	1763	c.1448T>G	c.(1447-1449)TTT>TGT	p.F483C		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	483	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ACTCACCCGAAAAACTGTCAT	0.418000													3	46					0	0	0.004672	0	0	
GRM3	2913	broad.mit.edu	37	7	86468386	86468386	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:86468386A>C	uc003uid.2	+	4	2655	c.1556A>C	c.(1555-1557)AAG>ACG	p.K519T	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.K391T|GRM3_uc010leh.2_Missense_Mutation_p.K111T	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	519	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AATGAAATGAAGAATATGCAA	0.522000													53	79					0	0	0.014410	0	0	
KIAA1324L	222223	broad.mit.edu	37	7	86539263	86539263	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:86539263T>G	uc011kha.1	-	16	2409	c.2224A>C	c.(2224-2226)ATA>CTA	p.I742L	KIAA1324L_uc003uif.1_Missense_Mutation_p.I502L|KIAA1324L_uc011kgz.1_Missense_Mutation_p.I628L|KIAA1324L_uc003uie.2_Missense_Mutation_p.I575L	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	742	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					CCTGCCACTATTTCTTTTACT	0.378000													24	49					0	0	0.003330	0	0	
CDK14	5218	broad.mit.edu	37	7	90675256	90675256	+	Silent	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:90675256T>A	uc003uky.2	+	11	1308	c.1086T>A	c.(1084-1086)TCT>TCA	p.S362S	CDK14_uc003ukz.1_Silent_p.S344S|CDK14_uc010les.1_Silent_p.S316S|CDK14_uc011khl.1_Silent_p.S233S	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	362	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						GAGTTCATTCTTTACCACATT	0.383000													4	55					0	0	0.009096	0	0	
DYNC1I1	1780	broad.mit.edu	37	7	95664938	95664938	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:95664938T>C	uc003uoc.3	+	13	1566	c.1289T>C	c.(1288-1290)ATG>ACG	p.M430T	DYNC1I1_uc003uod.3_Missense_Mutation_p.M413T|DYNC1I1_uc003uob.2_Missense_Mutation_p.M393T|DYNC1I1_uc003uoe.3_Missense_Mutation_p.M410T|DYNC1I1_uc010lfl.2_Missense_Mutation_p.M419T	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	430					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TAGGAGAGCATGGAGCTGGTG	0.468000													70	74					0	0	0.014410	0	0	
ACHE	43	broad.mit.edu	37	7	100490117	100490117	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:100490117C>T	uc003uxd.2	-	2	1547	c.1391G>A	c.(1390-1392)CGT>CAT	p.R464H	UFSP1_uc003uxc.3_5'Flank|ACHE_uc003uxe.2_Missense_Mutation_p.R464H|ACHE_uc003uxf.2_Missense_Mutation_p.R464H|ACHE_uc003uxg.2_Missense_Mutation_p.R464H|ACHE_uc003uxh.2_Missense_Mutation_p.R376H|ACHE_uc003uxi.2_Missense_Mutation_p.R464H	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	464					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CGTGGAAGCACGGTGTTCAAA	0.647000													36	34					0	0	0.005524	0	0	
RELN	5649	broad.mit.edu	37	7	103191603	103191603	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:103191603G>A	uc003vca.2	-	41	6373	c.6213C>T	c.(6211-6213)ACC>ACT	p.T2071T	RELN_uc010liz.2_Silent_p.T2071T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2071					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGTGGTGCTCGGTGGAGCATA	0.602000													27	35					0	0	0.004656	0	0	
RELN	5649	broad.mit.edu	37	7	103338447	103338447	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:103338447A>G	uc003vca.2	-	10	1156	c.996T>C	c.(994-996)AAT>AAC	p.N332N	RELN_uc010liz.2_Silent_p.N332N	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	332					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTACACGAAGATTTTCCTGCT	0.463000													19	182					0	0	0.006122	0	0	
PIK3CG	5294	broad.mit.edu	37	7	106545572	106545572	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:106545572T>C	uc003vdv.3	+	11	3134	c.3049T>C	c.(3049-3051)TAT>CAT	p.Y1017H	PIK3CG_uc003vdu.2_Missense_Mutation_p.Y1017H|PIK3CG_uc003vdw.2_Missense_Mutation_p.Y1017H	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	1017	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TGTTAAGGCTTATCTAGCCCT	0.398000													91	107					0	0	0.014410	0	0	
COG5	10466	broad.mit.edu	37	7	106924093	106924093	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:106924093G>C	uc003ved.2	-	13	2016	c.1491C>G	c.(1489-1491)ATC>ATG	p.I497M	COG5_uc003vec.2_Missense_Mutation_p.I497M|COG5_uc003vee.2_Missense_Mutation_p.I497M	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	497					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						AAACCAAGTTGATAGGATCGA	0.388000													20	116					0	0	0.012319	0	0	
FOXP2	93986	broad.mit.edu	37	7	114303506	114303506	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:114303506A>C	uc003vhb.2	+	15	2145	c.1771A>C	c.(1771-1773)AGT>CGT	p.S591R	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.S616R|FOXP2_uc003vha.2_Missense_Mutation_p.S499R|FOXP2_uc011kmu.1_Missense_Mutation_p.S608R|FOXP2_uc011kmv.1_Missense_Mutation_p.S590R|FOXP2_uc010ljz.1_Missense_Mutation_p.S406R|FOXP2_uc003vhe.1_Missense_Mutation_p.S161R	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	591	Fork-head.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TTTTTTCAGAAGTCCAACCTT	0.333000													40	44					0	0	0.006999	0	0	
LMOD2	442721	broad.mit.edu	37	7	123302861	123302861	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:123302861C>T	uc003vky.2	+	2	1378	c.1221C>T	c.(1219-1221)GTC>GTT	p.V407V		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	407	Pro-rich.					cytoskeleton	actin binding|tropomyosin binding				0						CCAAAAAAGTCCAGACTGTGA	0.363000													5	70					0	0	0.001168	0	0	
SLC37A3	84255	broad.mit.edu	37	7	140082276	140082276	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr7:140082276G>A	uc003vvo.2	-	2	217	c.51C>T	c.(49-51)AGC>AGT	p.S17S	SLC37A3_uc003vvp.2_Silent_p.S17S|SLC37A3_uc010lnh.2_Silent_p.S17S|SLC37A3_uc011kqz.1_RNA|SLC37A3_uc011kra.1_Silent_p.S17S|SLC37A3_uc011krb.1_Silent_p.S17S	NM_207113	NP_996996	Q8NCC5	SPX3_HUMAN	solute carrier family 37 (glycerol-3-phosphate	17	Helical; (Potential).				carbohydrate transport|transmembrane transport	integral to membrane				ovary(3)	3	Melanoma(164;0.0142)					CATGATGATGGCTGAACTGGG	0.443000													24	58					0	0	0.005443	0	0	
SLC7A2	6542	broad.mit.edu	37	8	17409284	17409284	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:17409284C>T	uc011kyc.1	+	6	1013	c.844C>T	c.(844-846)CGG>TGG	p.R282W	SLC7A2_uc011kyd.1_Missense_Mutation_p.R322W|SLC7A2_uc011kye.1_Missense_Mutation_p.R322W|SLC7A2_uc011kyf.1_Missense_Mutation_p.R282W	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	282	Cytoplasmic (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	TGAAGAAGTTCGGAATCCCCA	0.368000													49	44					0	0	0.014410	0	0	
LZTS1	11178	broad.mit.edu	37	8	20112401	20112401	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:20112401A>C	uc003wzr.2	-	1	403	c.292T>G	c.(292-294)TTT>GTT	p.F98V	LZTS1_uc010ltg.1_Missense_Mutation_p.F98V	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	98					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GACGGGTCAAAGTCCACCCCA	0.592000													4	31					0	0	0.009096	0	0	
PDLIM2	64236	broad.mit.edu	37	8	22442530	22442530	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:22442530G>A	uc003xby.2	+	5	716	c.316G>A	c.(316-318)GGC>AGC	p.G106S	PDLIM2_uc003xbx.1_Missense_Mutation_p.G106S|PDLIM2_uc003xbz.2_Missense_Mutation_p.G106S|PDLIM2_uc003xca.2_Missense_Mutation_p.G106S|PDLIM2_uc003xcb.2_Missense_Mutation_p.G106S|PDLIM2_uc003xcc.1_Missense_Mutation_p.G106S	NM_021630	NP_067643	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 isoform 2	106						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		CTCTCCACAGGGCTCCGTGAG	0.637000													4	48					0	0	0.001168	0	0	
FBXO16	157574	broad.mit.edu	37	8	28309947	28309947	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:28309947G>A	uc003xgu.2	-	6	652	c.554C>T	c.(553-555)ACA>ATA	p.T185I	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.T172I|FBXO16_uc003xgw.2_Missense_Mutation_p.T172I	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	185										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		AGAATTGCTTGTAACTAGTTG	0.378000													6	38					0	0	0.001168	0	0	
FUT10	84750	broad.mit.edu	37	8	33246606	33246606	+	Nonsense_Mutation	SNP	G	A	A	rs139904591	by1000genomes	TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:33246606G>A	uc003xje.2	-	4	1443	c.1087C>T	c.(1087-1089)CGA>TGA	p.R363*	FUT10_uc003xjc.2_Nonsense_Mutation_p.R370*|FUT10_uc003xjd.2_Nonsense_Mutation_p.R335*|FUT10_uc011lbi.1_Nonsense_Mutation_p.R413*|FUT10_uc003xjf.2_Nonsense_Mutation_p.R301*|FUT10_uc003xjg.2_Nonsense_Mutation_p.R335*|FUT10_uc003xjh.2_Nonsense_Mutation_p.R363*	NM_032664	NP_116053	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10	363	Lumenal (Potential).				embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			ovary(1)|pancreas(1)	2				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		GTCAGAAGTCGCTGGTTAGAG	0.493000													9	60					0	0	0.004482	0	0	
GOT1L1	137362	broad.mit.edu	37	8	37791994	37791994	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:37791994C>T	uc011lbj.1	-	9	1183	c.1083G>A	c.(1081-1083)GTG>GTA	p.V361V		NM_152413	NP_689626	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	361					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			ovary(1)	1	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			CCAGGTATTCCACCTGCTGGG	0.418000													19	107					0	0	0.008871	0	0	
FAM110B	90362	broad.mit.edu	37	8	59059700	59059700	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:59059700T>C	uc003xtj.1	+	5	1791	c.911T>C	c.(910-912)ATA>ACA	p.I304T		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	304						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				TCTGACATAATATCCCTCAAC	0.498000													50	50					0	0	0.014410	0	0	
CNBD1	168975	broad.mit.edu	37	8	88365898	88365898	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:88365898T>C	uc003ydy.2	+	10	1235	c.1187T>C	c.(1186-1188)CTT>CCT	p.L396P		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	396	cNMP.									ovary(3)	3						ATGGGGAAACTTAAGGAGAAG	0.323000													32	62					0	0	0.003271	0	0	
MMP16	4325	broad.mit.edu	37	8	89058904	89058904	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:89058904T>A	uc003yeb.3	-	9	1764	c.1482A>T	c.(1480-1482)AAA>AAT	p.K494N		NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	494	Hemopexin-like 4.|Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TACCATTTTCTTTGTGTACAA	0.393000													20	65					0	0	0.007413	0	0	
C8orf47	203111	broad.mit.edu	37	8	99101943	99101943	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:99101943G>C	uc003yih.1	+	2	846	c.698G>C	c.(697-699)GGA>GCA	p.G233A		NM_173549	NP_775820	Q6P6B1	CH047_HUMAN	hypothetical protein LOC203111	233	Glu-rich.										0	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			ATATTGGAAGGAAGTCAGTTT	0.468000													16	25					0	0	0.004007	0	0	
SPAG1	6674	broad.mit.edu	37	8	101252743	101252743	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:101252743T>G	uc003yjh.1	+	18	2479	c.2393T>G	c.(2392-2394)CTT>CGT	p.L798R	SPAG1_uc003yji.1_Missense_Mutation_p.L798R	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	798					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		CCTGAGAAACTTCCGATAGCC	0.488000													20	53					0	0	0.007413	0	0	
TM7SF4	81501	broad.mit.edu	37	8	105361735	105361735	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:105361735C>T	uc003ylx.1	+	2	1004	c.955C>T	c.(955-957)CGG>TGG	p.R319W		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	319					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TCTGCTGTATCGGCTCATTTT	0.473000													147	148					0	0	0.014410	0	0	
PTK2	5747	broad.mit.edu	37	8	141745365	141745365	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:141745365A>G	uc003yvu.2	-	22	2245	c.2015T>C	c.(2014-2016)CTT>CCT	p.L672P	PTK2_uc003yvo.2_Missense_Mutation_p.L300P|PTK2_uc011ljq.1_Missense_Mutation_p.L367P|PTK2_uc003yvp.2_Missense_Mutation_p.L340P|PTK2_uc003yvq.2_Missense_Mutation_p.L198P|PTK2_uc003yvr.2_Missense_Mutation_p.L612P|PTK2_uc003yvs.2_Missense_Mutation_p.L672P|PTK2_uc003yvt.2_Missense_Mutation_p.L694P|PTK2_uc003yvv.2_Missense_Mutation_p.L572P|PTK2_uc011ljr.1_Missense_Mutation_p.L672P|MIR151_hsa-mir-151|MI0000809_5'Flank	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	672	Protein kinase.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			CTGAGCTTTAAGTTCAGTAAA	0.522000													4	19					0	0	0.009096	0	0	
PPP1R16A	84988	broad.mit.edu	37	8	145725526	145725526	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr8:145725526A>T	uc003zdd.2	+	5	1437	c.524A>T	c.(523-525)GAC>GTC	p.D175V	uc003zde.1_5'Flank|PPP1R16A_uc003zdf.2_Missense_Mutation_p.D175V|GPT_uc011lli.1_5'Flank	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	175						plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			ATGCCCTATGACCTGTGTGAT	0.672000													6	18					0	0	0.008291	0	0	
AK3	50808	broad.mit.edu	37	9	4719266	4719266	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:4719266C>A	uc003ziq.1	-	3	453	c.313G>T	c.(313-315)GCT>TCT	p.A105S	AK3_uc003zip.1_RNA|AK3_uc011lma.1_Missense_Mutation_p.A65S|AK3_uc003zir.1_Missense_Mutation_p.A35S	NM_016282	NP_057366	Q9UIJ7	KAD3_HUMAN	adenylate kinase 3	105					blood coagulation	mitochondrial matrix	ATP binding|GTP binding|nucleoside triphosphate adenylate kinase activity			ovary(2)	2	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0302)		ATCTGATAAGCTCTATCTAGG	0.398000													28	58					3.90053e-15	4.21293e-15	0.012213	1	0	
RANBP6	26953	broad.mit.edu	37	9	6012492	6012492	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:6012492T>C	uc003zjr.2	-	1	3127	c.3116A>G	c.(3115-3117)AAT>AGT	p.N1039S	RANBP6_uc011lmf.1_Missense_Mutation_p.N687S|RANBP6_uc003zjs.2_Missense_Mutation_p.N627S	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	1039					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATTGGAATTATTTGGACCAAT	0.368000													29	43					0	0	0.007291	0	0	
MPDZ	8777	broad.mit.edu	37	9	13192277	13192277	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:13192277T>A	uc010mia.1	-	14	1878	c.1821A>T	c.(1819-1821)TTA>TTT	p.L607F	MPDZ_uc010mhy.2_Missense_Mutation_p.L607F|MPDZ_uc010mhz.2_Missense_Mutation_p.L607F|MPDZ_uc011lmn.1_Missense_Mutation_p.L607F|MPDZ_uc003zlb.3_Missense_Mutation_p.L607F	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	607	PDZ 4.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TTTCCCCAAGTAAAGTTATGC	0.348000													7	10					0	0	0.001984	0	0	
CNTLN	54875	broad.mit.edu	37	9	17273831	17273831	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:17273831T>G	uc003zmz.2	+	6	976	c.950T>G	c.(949-951)CTT>CGT	p.L317R	CNTLN_uc003zmx.3_Missense_Mutation_p.L317R|CNTLN_uc003zmy.2_Missense_Mutation_p.L317R|CNTLN_uc010mio.2_5'UTR	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	317						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		CAGACTGAACTTATCCAGAAG	0.303000													22	113					0	0	0.012319	0	0	
ADAMTSL1	92949	broad.mit.edu	37	9	18795443	18795443	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:18795443A>C	uc003zne.3	+	20	3853	c.3726A>C	c.(3724-3726)GAA>GAC	p.E1242D		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1242	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CACCAGTGGAAGCAGATGTGG	0.463000													8	93					0	0	0.004482	0	0	
FLJ46321	389763	broad.mit.edu	37	9	84610036	84610036	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:84610036T>G	uc004amn.2	+	4	4698	c.4651T>G	c.(4651-4653)TTT>GTT	p.F1551V		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1551						integral to membrane					0						AAGCCCTGTGTTTAGTGATGT	0.507000													10	13					0	0	0.006214	0	0	
KIF27	55582	broad.mit.edu	37	9	86518567	86518567	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:86518567G>A	uc004ana.2	-	4	1010	c.866C>T	c.(865-867)TCA>TTA	p.S289L	KIF27_uc010mpw.2_Missense_Mutation_p.S289L|KIF27_uc010mpx.2_Missense_Mutation_p.S289L	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	289					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TGGAATATGTGAACTCTTCCT	0.453000													50	64					0	0	0.014410	0	0	
CTSL1	1514	broad.mit.edu	37	9	90344590	90344590	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:90344590G>A	uc004aph.2	+	6	1074	c.724G>A	c.(724-726)GTG>ATG	p.V242M	CTSL1_uc004api.2_Missense_Mutation_p.V242M|CTSL1_uc004apj.2_Missense_Mutation_p.V187M|CTSL1_uc010mqh.2_Missense_Mutation_p.V60M|CTSL1_uc004apk.2_Missense_Mutation_p.V242M|CTSL1_uc004apl.2_Missense_Mutation_p.V242M	NM_001912	NP_001903	P07711	CATL1_HUMAN	cathepsin L1 preproprotein	242					macrophage apoptosis|proteolysis	extracellular region|lysosome|nucleus	cysteine-type endopeptidase activity|histone binding			ovary(3)	3					Glucagon recombinant(DB00040)	AGTTGCAACTGTGGGGCCCAT	0.428000													16	85					0	0	0.006122	0	0	
CYLC2	1539	broad.mit.edu	37	9	105767737	105767737	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:105767737A>C	uc004bbs.2	+	5	894	c.824A>C	c.(823-825)AAG>ACG	p.K275T		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	275	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				AAAGATAAGAAGAAGCCCAGT	0.259000													5	56					0	0	0.001168	0	0	
COL5A1	1289	broad.mit.edu	37	9	137622253	137622253	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:137622253C>T	uc004cfe.2	+	7	1478	c.1096C>T	c.(1096-1098)CAG>TAG	p.Q366*		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	366	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GAACCCCGACCAGCCCACAGA	0.592000													42	76					0	0	0.011902	0	0	
GLT6D1	360203	broad.mit.edu	37	9	138515964	138515964	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:138515964A>C	uc010nbd.1	-	5	1064	c.810T>G	c.(808-810)TTT>TTG	p.F270L		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	270	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		TATTGAGGTAAAAATATTTGT	0.368000													3	103					0	0	0.004672	0	0	
CACNA1B	774	broad.mit.edu	37	9	141006876	141006876	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:141006876G>A	uc004cog.2	+	39	5600	c.5455G>A	c.(5455-5457)GCG>ACG	p.A1819T	CACNA1B_uc004coi.2_Missense_Mutation_p.A1031T|CACNA1B_uc004cok.1_RNA|CACNA1B_uc010ncp.1_Missense_Mutation_p.A99T	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1819	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCAGTGTGACGCGGAGTTGAG	0.557000													21	33					0	0	0.012319	0	0	
GYG2	8908	broad.mit.edu	37	X	2799210	2799210	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:2799210G>A	uc004cqs.1	+	12	1744	c.1462G>A	c.(1462-1464)GCG>ACG	p.A488T	GYG2_uc004cqt.1_Missense_Mutation_p.A457T|GYG2_uc004cqu.1_Missense_Mutation_p.A456T|GYG2_uc004cqv.1_Missense_Mutation_p.A231T|GYG2_uc004cqw.1_Missense_Mutation_p.A448T|GYG2_uc004cqx.1_Missense_Mutation_p.A386T|GYG2_uc010ndc.1_Missense_Mutation_p.A266T	NM_003918	NP_003909	O15488	GLYG2_HUMAN	glycogenin 2 isoform b	488					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			ovary(1)|kidney(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGGGAAGGACGCGTTTGCTCG	0.557000													3	18					0	0	0.004672	0	0	
TBL1X	6907	broad.mit.edu	37	X	9679769	9679769	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:9679769T>G	uc010ndq.2	+	16	1926	c.1558T>G	c.(1558-1560)TTG>GTG	p.L520V	TBL1X_uc004csq.3_Missense_Mutation_p.L469V|TBL1X_uc010ndr.2_Missense_Mutation_p.L469V|TBL1X_uc004csr.2_Missense_Mutation_p.L520V|TBL1X_uc004css.2_Missense_Mutation_p.L471V	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	520	WD 7.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				TGGGAAGTACTTGGCCAGTGG	0.532000													10	52					0	0	0.008291	0	0	
AMELX	265	broad.mit.edu	37	X	11316822	11316822	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:11316822T>G	uc004cut.2	+	5	367	c.299T>G	c.(298-300)ATG>AGG	p.M100R	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Missense_Mutation_p.M114R|AMELX_uc004cuu.2_Missense_Mutation_p.M84R	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	100					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						CAGCAACCAATGATGCCCGTT	0.642000													10	156					0	0	0.008291	0	0	
TLR7	51284	broad.mit.edu	37	X	12905418	12905418	+	Silent	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:12905418T>A	uc004cvc.2	+	3	1930	c.1791T>A	c.(1789-1791)GTT>GTA	p.V597V		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	597	LRR 20.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ACCTAAAGGTTCTGCAGAAAC	0.398000													57	122					0	0	0.014410	0	0	
ACE2	59272	broad.mit.edu	37	X	15599426	15599426	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:15599426T>G	uc004cxa.1	-	8	1156	c.988A>C	c.(988-990)AAT>CAT	p.N330H	ACE2_uc004cxb.2_Missense_Mutation_p.N330H	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	330	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	AGCATGGAATTTTCCCAGAAT	0.493000													25	192					0	0	0.003954	0	0	
BEND2	139105	broad.mit.edu	37	X	18221885	18221885	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:18221885T>G	uc004cyj.3	-	5	797	c.643A>C	c.(643-645)AGT>CGT	p.S215R	BEND2_uc010nfb.2_Missense_Mutation_p.S215R	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	215										ovary(3)|kidney(1)|central_nervous_system(1)	5						TGTAATGAACTTGAGGAGACA	0.468000													8	182					0	0	0.004482	0	0	
FAM48B1	100130302	broad.mit.edu	37	X	24382605	24382605	+	Silent	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:24382605C>T	uc011mjx.1	+	1	1728	c.1728C>T	c.(1726-1728)CTC>CTT	p.L576L		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						CTGTGCCTCTCATTCAAGCTA	0.378000													3	20					0	0	0.009096	0	0	
DMD	1756	broad.mit.edu	37	X	31645908	31645908	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:31645908T>G	uc004dda.1	-	55	8343	c.8099A>C	c.(8098-8100)AAG>ACG	p.K2700T	DMD_uc004dcr.1_Missense_Mutation_p.K240T|DMD_uc004dcs.1_Missense_Mutation_p.K240T|DMD_uc004dct.1_Missense_Mutation_p.K240T|DMD_uc004dcu.1_Missense_Mutation_p.K240T|DMD_uc004dcv.1_Missense_Mutation_p.K240T|DMD_uc004dcw.2_Missense_Mutation_p.K1356T|DMD_uc004dcx.2_Missense_Mutation_p.K1359T|DMD_uc004dcz.2_Missense_Mutation_p.K2577T|DMD_uc004dcy.1_Missense_Mutation_p.K2696T|DMD_uc004ddb.1_Missense_Mutation_p.K2692T	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2700	Spectrin 19.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGCAAGAAACTTTTCCAGGTC	0.478000													3	29					0	0	0.004672	0	0	
FAM47A	158724	broad.mit.edu	37	X	34150170	34150170	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:34150170A>T	uc004ddg.2	-	1	259	c.226T>A	c.(226-228)TTT>ATT	p.F76I		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	76										ovary(4)|central_nervous_system(1)	5						GGGAGTAAAAACTCGTCACGG	0.532000													5	138					0	0	0.000602	0	0	
MAGEB16	139604	broad.mit.edu	37	X	35820769	35820769	+	Silent	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:35820769T>C	uc010ngt.1	+	2	735	c.456T>C	c.(454-456)TCT>TCC	p.S152S		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	152	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						GCCACTTCTCTGAGATCCTCC	0.443000													35	83					0	0	0.003755	0	0	
ATP6AP2	10159	broad.mit.edu	37	X	40460100	40460100	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:40460100G>C	uc004det.2	+	8	927	c.825G>C	c.(823-825)AGG>AGC	p.R275S	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Missense_Mutation_p.R199S|ATP6AP2_uc011mkm.1_Missense_Mutation_p.R243S|ATP6AP2_uc011mkn.1_Missense_Mutation_p.R197S|ATP6AP2_uc004deu.1_Missense_Mutation_p.R140S	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	275	Extracellular (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0						CCCTCATTAGGAAGACAAGGA	0.358000													40	43					0	0	0.006999	0	0	
MED14	9282	broad.mit.edu	37	X	40552032	40552032	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:40552032G>C	uc004dex.3	-	14	1913	c.1773C>G	c.(1771-1773)TTC>TTG	p.F591L		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	591	Interaction with SREBF1.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						TGTTTTCCTTGAACTGCTGCA	0.448000													17	62					0	0	0.007413	0	0	
USP11	8237	broad.mit.edu	37	X	47104478	47104478	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:47104478A>T	uc004dhp.2	+	16	2279	c.2279A>T	c.(2278-2280)GAG>GTG	p.E760V	USP11_uc004dhq.2_Missense_Mutation_p.E486V	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	760					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GACGAGGTAGAGGCTGAGGTA	0.562000													4	41					0	0	0.009096	0	0	
SYN1	6853	broad.mit.edu	37	X	47434138	47434138	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:47434138T>C	uc004die.2	-	11	1471	c.1342A>G	c.(1342-1344)ACC>GCC	p.T448A	SYN1_uc004did.2_Missense_Mutation_p.T448A	NM_006950	NP_008881	P17600	SYN1_HUMAN	synapsin I isoform Ia	448	D; Pro-rich linker.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			ovary(1)	1						TGCTGGGAGGTCTGGCGGCCC	0.677000													7	13					0	0	0.003080	0	0	
ZNF81	347344	broad.mit.edu	37	X	47775719	47775719	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:47775719T>A	uc010nhy.1	+	6	2042	c.1674T>A	c.(1672-1674)GAT>GAA	p.D558E		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	558	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				TTTGTGCTGATTGTGGGAGGG	0.423000													5	42					0	0	0.000602	0	0	
IQSEC2	23096	broad.mit.edu	37	X	53265548	53265548	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:53265548T>G	uc004dsd.2	-	13	3608	c.3407A>C	c.(3406-3408)AAA>ACA	p.K1136T	IQSEC2_uc004dsc.2_Missense_Mutation_p.K931T	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	1126					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						TGCGCCCCGTTTGAGCCCATC	0.657000													3	15					0	0	0.004672	0	0	
ALAS2	212	broad.mit.edu	37	X	55041235	55041235	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:55041235A>C	uc004dua.3	-	9	1520	c.1382T>G	c.(1381-1383)CTC>CGC	p.L461R	ALAS2_uc004dub.3_Missense_Mutation_p.L448R|ALAS2_uc004dud.3_Missense_Mutation_p.L424R	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	461					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	CCTGTCCATGAGTAGCTGGCG	0.607000													6	9					0	0	0.001168	0	0	
LAS1L	81887	broad.mit.edu	37	X	64738169	64738169	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:64738169G>A	uc004dwa.1	-	12	1697	c.1625C>T	c.(1624-1626)GCC>GTC	p.A542V	LAS1L_uc004dwc.1_Missense_Mutation_p.A525V|LAS1L_uc004dwd.1_Missense_Mutation_p.A483V|LAS1L_uc004dvy.1_Missense_Mutation_p.A55V|LAS1L_uc004dvz.1_Missense_Mutation_p.A55V	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	542						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						GCTGGAGCTGGCTGGCTTGAC	0.552000													12	129					0	0	0.004007	0	0	
CXorf65	158830	broad.mit.edu	37	X	70323883	70323883	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:70323883T>G	uc011mpo.1	-	6	520	c.506A>C	c.(505-507)AAG>ACG	p.K169T	CXorf65_uc011mpp.1_Missense_Mutation_p.K121T	NM_001025265	NP_001020436	A6NEN9	CX065_HUMAN	hypothetical protein LOC158830	169										central_nervous_system(1)	1						ACCTTTATTCTTCCTGAAGTC	0.383000													7	61					0	0	0.001984	0	0	
ITGB1BP2	26548	broad.mit.edu	37	X	70523493	70523493	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:70523493A>T	uc004dzr.1	+	7	514	c.485A>T	c.(484-486)GAG>GTG	p.E162V	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_Missense_Mutation_p.E144V	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	162	Cys-rich.|CHORD 2.				muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					CAAGGCCCTGAGAGTGATGCT	0.512000													7	73					0	0	0.004482	0	0	
NHSL2	340527	broad.mit.edu	37	X	71360037	71360037	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:71360037G>A	uc011mqa.1	+	6	2639	c.2639G>A	c.(2638-2640)AGG>AAG	p.R880K	NHSL2_uc004eak.1_Missense_Mutation_p.R514K|NHSL2_uc010nli.2_Missense_Mutation_p.R649K	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	880											0	Renal(35;0.156)					GTGGCCCGGAGGCCTCCAAGC	0.557000													10	61					0	0	0.006214	0	0	
NHSL2	340527	broad.mit.edu	37	X	71360088	71360088	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:71360088T>C	uc011mqa.1	+	6	2690	c.2690T>C	c.(2689-2691)CTA>CCA	p.L897P	NHSL2_uc004eak.1_Missense_Mutation_p.L531P|NHSL2_uc010nli.2_Missense_Mutation_p.L666P	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	897											0	Renal(35;0.156)					GAGTATGCACTAACTTCACCA	0.562000													42	55					0	0	0.010771	0	0	
NAP1L2	4674	broad.mit.edu	37	X	72433801	72433801	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:72433801A>G	uc004ebi.2	-	1	884	c.528T>C	c.(526-528)GAT>GAC	p.D176D	NAP1L2_uc011mqj.1_Silent_p.D34D	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	176	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					TTTCCTCATCATCACAGTCCT	0.383000													9	139					0	0	0.006214	0	0	
RLIM	51132	broad.mit.edu	37	X	73812036	73812036	+	Silent	SNP	G	T	T	rs61754467		TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:73812036G>T	uc004ebu.2	-	5	1404	c.1114C>A	c.(1114-1116)CGG>AGG	p.R372R	RLIM_uc004ebw.2_Silent_p.R372R	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	372					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						ACACCTGCCCGCTCAGAACGT	0.443000													22	131					2.21704e-12	2.36217e-12	0.002780	1	0	
KIAA2022	340533	broad.mit.edu	37	X	73963244	73963244	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:73963244T>C	uc004eby.2	-	3	1765	c.1148A>G	c.(1147-1149)AAG>AGG	p.K383R		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	383					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTTGCCTTTCTTCTTGTCCAA	0.453000													9	321					0	0	0.004482	0	0	
ATRX	546	broad.mit.edu	37	X	76918897	76918897	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:76918897T>G	uc004ecp.3	-	12	4326	c.4094A>C	c.(4093-4095)GAA>GCA	p.E1365A	ATRX_uc004ecq.3_Missense_Mutation_p.E1327A|ATRX_uc004eco.3_Missense_Mutation_p.E1150A|ATRX_uc004ecr.2_Missense_Mutation_p.E1297A	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1365					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GCCTTTGACTTCTTTATGCTC	0.323000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						22	173					0	0	0.005443	0	0	
ATRX	546	broad.mit.edu	37	X	76939970	76939970	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:76939970T>G	uc004ecp.3	-	9	1010	c.778A>C	c.(778-780)AAC>CAC	p.N260H	ATRX_uc004ecq.3_Missense_Mutation_p.N222H|ATRX_uc004eco.3_Missense_Mutation_p.N45H|ATRX_uc004ecr.2_Missense_Mutation_p.N221H|ATRX_uc010nlx.1_Missense_Mutation_p.N260H|ATRX_uc010nly.1_Missense_Mutation_p.N205H	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	260	ADD.|PHD-type; atypical.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CATTGGTTGTTTTCATCCATT	0.403000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						47	360					0	0	0.014410	0	0	
CHM	1121	broad.mit.edu	37	X	85155675	85155675	+	Silent	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:85155675G>A	uc004eet.2	-	11	1419	c.1389C>T	c.(1387-1389)GTC>GTT	p.V463V	CHM_uc011mqz.1_Silent_p.V315V	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	463					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				CTGTTTTTAGGACAGATCTAT	0.269000													7	19					0	0	0.004482	0	0	
PCDH11X	27328	broad.mit.edu	37	X	91132001	91132001	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:91132001T>G	uc004efk.1	+	2	1607	c.762T>G	c.(760-762)ATT>ATG	p.I254M	PCDH11X_uc004efl.1_Missense_Mutation_p.I254M|PCDH11X_uc004efo.1_Missense_Mutation_p.I254M|PCDH11X_uc010nmv.1_Missense_Mutation_p.I254M|PCDH11X_uc004efm.1_Missense_Mutation_p.I254M|PCDH11X_uc004efn.1_Missense_Mutation_p.I254M|PCDH11X_uc004efh.1_Missense_Mutation_p.I254M|PCDH11X_uc004efj.1_Missense_Mutation_p.I254M	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	254	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						AGACAGAGATTGAAGTCAGTA	0.433000													29	110					0	0	0.004289	0	0	
PCDH11X	27328	broad.mit.edu	37	X	91873823	91873823	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:91873823A>G	uc004efk.1	+	7	4773	c.3928A>G	c.(3928-3930)AGA>GGA	p.R1310G	PCDH11X_uc004efl.1_Missense_Mutation_p.R1300G|PCDH11X_uc004efo.1_Missense_Mutation_p.R1273G|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.R1302G|PCDH11X_uc004efn.1_Missense_Mutation_p.R1292G	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1310	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CATGTCTGAAAGACTTCATCC	0.483000													13	337					0	0	0.004990	0	0	
TCEAL3	85012	broad.mit.edu	37	X	102864315	102864315	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:102864315G>A	uc004ekq.2	+	3	585	c.323G>A	c.(322-324)CGG>CAG	p.R108Q	TCEAL3_uc004ekr.2_Missense_Mutation_p.R108Q	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						TATGTGCCCCGGAAAGCAAAA	0.597000													73	157					0	0	0.014410	0	0	
RAB9B	51209	broad.mit.edu	37	X	103080330	103080330	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:103080330C>A	uc004ell.1	-	3	670	c.385G>T	c.(385-387)GAG>TAG	p.E129*	RAB9B_uc004eli.1_Intron	NM_016370	NP_057454	Q9NP90	RAB9B_HUMAN	RAB9B, member RAS oncogene family	129					Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(3)	3						TGCCTATCCTCTTTGTCTACC	0.433000													8	525					0.000274275	0.000282659	0.004482	1	0	
FAM199X	139231	broad.mit.edu	37	X	103431172	103431172	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:103431172T>C	uc004elw.2	+	4	765	c.599T>C	c.(598-600)GTG>GCG	p.V200A	FAM199X_uc004elx.2_Missense_Mutation_p.V17A	NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	200										ovary(1)	1						AGTCGGAAAGTGAGTACTGAG	0.333000													7	116					0	0	0.004482	0	0	
MUM1L1	139221	broad.mit.edu	37	X	105450489	105450489	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:105450489C>A	uc004emf.1	+	4	1713	c.1064C>A	c.(1063-1065)TCT>TAT	p.S355Y	MUM1L1_uc004emg.1_Missense_Mutation_p.S355Y	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	355										ovary(2)|pancreas(1)|skin(1)	4						GGTCAAGCCTCTGACAAGTCA	0.388000													7	36					8.12818e-05	8.43187e-05	0.001984	1	0	
ATG4A	115201	broad.mit.edu	37	X	107396918	107396918	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:107396918A>C	uc004enr.2	+	13	1296	c.1173A>C	c.(1171-1173)GAA>GAC	p.E391D	ATG4A_uc004ent.2_Missense_Mutation_p.E329D|ATG4A_uc004ens.2_Missense_Mutation_p.E307D|ATG4A_uc011msl.1_Missense_Mutation_p.E245D|ATG4A_uc010npi.2_RNA|ATG4A_uc004enu.2_Missense_Mutation_p.E307D|COL4A6_uc011msm.1_Intron	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	391					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						ATCTGGAGGAAGATTTTGAGA	0.388000													35	207					0	0	0.006230	0	0	
GUCY2F	2986	broad.mit.edu	37	X	108652293	108652293	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:108652293T>G	uc004eod.3	-	9	2172	c.1896A>C	c.(1894-1896)GAA>GAC	p.E632D	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	632	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TCAGTATGTCTTCTAGGCTCC	0.408000													5	219					0	0	0.001168	0	0	
TDGF3	6998	broad.mit.edu	37	X	109764906	109764906	+	RNA	SNP	T	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:109764906T>G	uc004eos.1	+	1		c.1367T>G				NR_002718				Human (clone CR-3) teratocarcinoma-derived growth factor 3 (TDGF3) mRNA, complete cds.												0						TCTGCCTTTCTATACAAAGCT	0.433000													6	102					0	0	0.001984	0	0	
DOCK11	139818	broad.mit.edu	37	X	117700536	117700536	+	Splice_Site	SNP	G	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:117700536G>A	uc004eqp.2	+	9	935	c.872_splice	c.e9-1	p.D291_splice	DOCK11_uc004eqq.2_Splice_Site_p.D57_splice	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11						blood coagulation	cytosol	GTP binding			ovary(3)	3						TGAATTTGCAGATGATGAAAC	0.413000													12	36					0	0	0.013537	0	0	
GLUD2	2747	broad.mit.edu	37	X	120182817	120182817	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:120182817G>T	uc004eto.2	+	1	1356	c.1279G>T	c.(1279-1281)GAT>TAT	p.D427Y		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	427					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	GGTTATTCCAGATCTCTACTT	0.428000													63	273					1.55088e-19	1.69449e-19	0.014410	1	0	
ODZ1	10178	broad.mit.edu	37	X	123540219	123540219	+	Silent	SNP	G	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:123540219G>T	uc004euj.2	-	25	5146	c.5082C>A	c.(5080-5082)GTC>GTA	p.V1694V	ODZ1_uc011muj.1_Silent_p.V1700V|ODZ1_uc010nqy.2_Silent_p.V1701V	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1694	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTGACATGAGGACATTTTCAC	0.438000													76	177					4.09166e-32	4.52286e-32	0.014410	1	0	
ODZ1	10178	broad.mit.edu	37	X	123775705	123775705	+	Silent	SNP	A	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:123775705A>C	uc004euj.2	-	11	2077	c.2013T>G	c.(2011-2013)ACT>ACG	p.T671T	ODZ1_uc011muj.1_Silent_p.T670T|ODZ1_uc010nqy.2_Silent_p.T671T	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	671	EGF-like 5.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CCAGAAGAAAAGTTCCGTGTC	0.478000													103	279					0	0	0.014410	0	0	
BCORL1	63035	broad.mit.edu	37	X	129159091	129159091	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:129159091A>G	uc004evb.1	+	7	3929	c.3815A>G	c.(3814-3816)CAA>CGA	p.Q1272R	BCORL1_uc010nrd.1_Intron|BCORL1_uc004evc.1_Missense_Mutation_p.Q34R	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1272					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						AGAAAGACCCAACGGGACACC	0.592000													14	180					0	0	0.002450	0	0	
PLAC1	10761	broad.mit.edu	37	X	133700336	133700336	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:133700336T>A	uc004exo.1	-	3	663	c.377A>T	c.(376-378)AAG>ATG	p.K126M	PLAC1_uc004exp.1_Missense_Mutation_p.K126M	NM_021796	NP_068568	Q9HBJ0	PLAC1_HUMAN	placenta-specific 1 precursor	126					placenta development	extracellular region				pancreas(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GGAGCAGGGCTTGGTGAGCCA	0.537000													12	236					0	0	0.010729	0	0	
LDOC1	23641	broad.mit.edu	37	X	140271010	140271010	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:140271010T>A	uc004fbj.2	-	1	301	c.197A>T	c.(196-198)GAG>GTG	p.E66V		NM_012317	NP_036449	O95751	LDOC1_HUMAN	leucine zipper, down-regulated in cancer 1	66					negative regulation of cell proliferation	nucleus	protein binding				0	Acute lymphoblastic leukemia(192;7.65e-05)					CACGATAAACTCGGGGAGCCG	0.617000													41	66					0	0	0.006230	0	0	
AFF2	2334	broad.mit.edu	37	X	147743468	147743468	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:147743468A>T	uc004fcp.2	+	3	699	c.220A>T	c.(220-222)ACG>TCG	p.T74S	AFF2_uc004fco.2_Missense_Mutation_p.T70S|AFF2_uc004fcq.2_Missense_Mutation_p.T70S|AFF2_uc004fcr.2_Missense_Mutation_p.T70S|AFF2_uc011mxb.1_Missense_Mutation_p.T74S|AFF2_uc004fcs.2_Missense_Mutation_p.T70S	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	74					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AGTCCAGAACACGCTTGGAAA	0.403000													32	212					0	0	0.003271	0	0	
IDS	3423	broad.mit.edu	37	X	148586601	148586601	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:148586601C>T	uc011mxe.1	-	1	265	c.67G>A	c.(67-69)GCC>ACC	p.A23T	IDS_uc011mxf.1_5'UTR|IDS_uc011mxg.1_5'UTR|IDS_uc010nsu.1_Intron|IDS_uc004fcw.3_Intron|IDS_uc011mxh.1_Missense_Mutation_p.A23T|IDS_uc011mxi.1_RNA|IDS_uc011mxj.1_Missense_Mutation_p.A23T	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	23						lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GATCCGAGGGCGACGCAGACG	0.527000													44	40					0	0	0.014410	0	0	
MECP2	4204	broad.mit.edu	37	X	153296057	153296057	+	Silent	SNP	A	G	G			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:153296057A>G	uc004fjv.2	-	4	1448	c.1222T>C	c.(1222-1224)TTG>CTG	p.L408L	MECP2_uc004fjw.2_Silent_p.L420L	NM_004992	NP_004983	P51608	MECP2_HUMAN	methyl CpG binding protein 2 isoform 1	408					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGCTGCTCAAGTCCTGGGGC	0.682000													23	206					0	0	0.002780	0	0	
GDI1	2664	broad.mit.edu	37	X	153668347	153668347	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:153668347T>C	uc004fli.3	+	5	790	c.448T>C	c.(448-450)TTC>CTC	p.F150L	GDI1_uc011mzo.1_Missense_Mutation_p.F150L|GDI1_uc004flj.2_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	150				NFD -> GTY (in Ref. 2; BAA08078).	protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGTGGCAAACTTCGATGAGAA	0.542000													63	632					0	0	0.014410	0	0	
VAMP7	6845	broad.mit.edu	37	X	155127890	155127890	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:155127890T>C	uc004fnr.2	+	4	493	c.319T>C	c.(319-321)TCA>CCA	p.S107P	VAMP7_uc004fnt.2_Missense_Mutation_p.S66P|VAMP7_uc011naa.1_Missense_Mutation_p.S68P|VAMP7_uc011nab.1_Missense_Mutation_p.S6P|VAMP7_uc004fns.2_Missense_Mutation_p.S107P|VAMP7_uc011nac.1_Missense_Mutation_p.S40P	NM_005638	NP_005629	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7 isoform 1	107	Longin.|Cytoplasmic (Potential).				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TAGCGAGTTCTCAAGTGTCTT	0.408000													6	164					0	0	0.001984	0	0	
PIK3R1	5295	broad.mit.edu	37	5	67575545	67575545	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:67575545delG	uc003jva.2	+	5	1178	c.618delG	c.(616-618)ATGfs	p.M206fs	PIK3R1_uc003jvb.2_Frame_Shift_Del_p.M206fs	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	206	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	ACAGTGAAATGATTTCTTTAG	0.403			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			37	21	---	---	---	---						.
APC	324	broad.mit.edu	37	5	112175951	112175952	+	Frame_Shift_Ins	INS	-	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr5:112175951_112175952insA	uc010jby.2	+	16	5040_5041	c.4660_4661insA	c.(4660-4662)GAAfs	p.E1554fs	APC_uc011cvt.1_Frame_Shift_Ins_p.E1536fs|APC_uc003kpz.3_Frame_Shift_Ins_p.E1554fs|APC_uc003kpy.3_Frame_Shift_Ins_p.E1554fs|APC_uc010jbz.2_Frame_Shift_Ins_p.E1271fs|APC_uc010jca.2_Frame_Shift_Ins_p.E854fs	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1554	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.T1556fs*3(35)|p.E1554fs*5(2)|p.E1554*(2)|p.?(1)|p.T1556fs*9(1)|p.K1192fs*3(1)|p.?fs(1)|p.E1554fs*11(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GAAAGAGGCAGAAAAAACTATT	0.342		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			20	21	---	---	---	---						.
C9orf84	158401	broad.mit.edu	37	9	114454528	114454529	+	Frame_Shift_Ins	INS	-	A	A			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chr9:114454528_114454529insA	uc004bfr.2	-	25	3671_3672	c.3536_3537insT	c.(3535-3537)TTAfs	p.L1179fs	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Frame_Shift_Ins_p.L1140fs|C9orf84_uc010mug.2_Frame_Shift_Ins_p.L1090fs	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	1179										ovary(2)	2						TCACAGGTGGTAAAAAACTTGA	0.351													43	89	---	---	---	---						.
CXorf56	63932	broad.mit.edu	37	X	118694316	118694316	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D7-6528-01A-11D-1800-08	TCGA-D7-6528-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	153a64ee-6322-4f2e-b3df-77ef7d3a4cf0	c7abc1e5-aa3a-44df-bfca-490332206b15	g.chrX:118694316delG	uc004erk.1	-	2	203	c.157delC	c.(157-159)CGGfs	p.R53fs	CXorf56_uc004erj.1_Frame_Shift_Del_p.R4fs|CXorf56_uc011mtu.1_Frame_Shift_Del_p.R53fs	NM_022101	NP_071384	Q9H5V9	CX056_HUMAN	hypothetical protein LOC63932	53							protein binding				0						GACCGGTCCCGGGGCCTCATG	0.463													155	138	---	---	---	---						.
