Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RTP1	132112	broad.mit.edu	37	3	186917353	186917353	+	Missense_Mutation	SNP	G	T	T			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr3:186917353G>T	uc003frg.3	+	1	317	c.287G>T	c.(286-288)tGg>tTg	p.W96L		NM_153708	NP_714919	P59025	RTP1_HUMAN	Homo sapiens receptor (chemosensory) transporter protein 1 (RTP1), mRNA.	96					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		CACTGCTCCTGGTGCTGGCAC	0.652000														50			53		4.88482e-21	6.10603e-21	1	1	0
CEPT1	10390	broad.mit.edu	37	1	111690383	111690383	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr1:111690383C>T	uc001eah.1	+	1	255	c.47C>T	c.(46-48)cCg>cTg	p.P16L	CEPT1_uc001eag.3_Missense_Mutation_p.P16L|CEPT1_uc001eai.1_Missense_Mutation_p.P16L|CEPT1_uc001eaj.1_Missense_Mutation_p.P16L	NM_001007794	NP_006081	Q9Y6K0	CEPT1_HUMAN	Homo sapiens choline/ethanolamine phosphotransferase 1 (CEPT1), transcript variant 2, mRNA.	16						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	8		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)	GATTCTCACCCGGAGTCCCCA	0.393000														45			5		0	0	1	0	0
SLC25A45	283130	broad.mit.edu	37	11	65144072	65144072	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr11:65144072T>C	uc001odr.1	-	6	877	c.673A>G	c.(673-675)Atc>Gtc	p.I225V	SLC25A45_uc009yqi.1_Missense_Mutation_p.I163V|SLC25A45_uc001odq.1_Missense_Mutation_p.I201V|SLC25A45_uc001ods.1_Missense_Mutation_p.I183V|SLC25A45_uc001odt.1_Missense_Mutation_p.I183V	NM_182556	NP_001070709	Q8N413	S2545_HUMAN	Homo sapiens solute carrier family 25, member 45 (SLC25A45), transcript variant 1, mRNA.	225					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	14						CGGGACTTGATCATGTCTAAG	0.617000														33			29		0	0	1	0	0
PCID2	55795	broad.mit.edu	37	13	113854783	113854783	+	Missense_Mutation	SNP	C	A	A			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr13:113854783C>A	uc021rmt.1	-	1	165	c.84G>T	c.(82-84)ttG>ttT	p.L28F	PCID2_uc021rmq.1_Missense_Mutation_p.L28F|PCID2_uc021rmr.1_Missense_Mutation_p.L28F|PCID2_uc021rms.1_Missense_Mutation_p.L28F|PCID2_uc001vtg.2_Non-coding_Transcript	NM_018386	NP_060856	Q5JVF3	PCID2_HUMAN	Homo sapiens PCI domain containing 2 (PCID2), transcript variant 3, mRNA.	28					negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)	20	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			TAAAAGACACCAACTCTGCAC	0.423000														63			5		0.00198382	0.00208823	1	1	0
CCDC155	147872	broad.mit.edu	37	19	49920492	49920492	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr19:49920492G>A	uc002pnm.2	+	18	1721	c.1516G>A	c.(1516-1518)Ggc>Agc	p.G506S	CCDC155_uc010emx.2_Missense_Mutation_p.G477S	NM_144688	NP_653289	Q8N6L0	CC155_HUMAN	Homo sapiens coiled-coil domain containing 155 (CCDC155), mRNA.	506						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						GAGGGCCTGGGGCCAGCTCTG	0.652000														15			7		0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101188796	101188796	+	Missense_Mutation	SNP	G	T	T			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr1:101188796G>T	uc001dti.3	+	2	782	c.561G>T	c.(559-561)gaG>gaT	p.E187D	VCAM1_uc010ouj.2_Missense_Mutation_p.E125D|VCAM1_uc001dtj.3_Missense_Mutation_p.E187D	NM_001078	NP_001069	P19320	VCAM1_HUMAN	Homo sapiens vascular cell adhesion molecule 1 (VCAM1), transcript variant 1, mRNA.	187	Ig-like C2-type 2.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CTGTCATTGAGGATATTGGAA	0.418000														13			19		3.51602e-12	4.13649e-12	1	1	0
SLC35G3	146861	broad.mit.edu	37	17	33521307	33521307	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr17:33521307T>C	uc002hjd.2	-	0	106	c.20A>G	c.(19-21)tAt>tGt	p.Y7C		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	Homo sapiens solute carrier family 35, member G3 (SLC35G3), mRNA.	7						integral to membrane											CTGGTTGAAATAGGGGTGACT	0.632000														45			3		0	0	1	0	0
HELLS	3070	broad.mit.edu	37	10	96361328	96361328	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr10:96361328A>G	uc009xuo.3	+	22	2709	c.2604A>G	c.(2602-2604)atA>atG	p.I868M	HELLS_uc001kjs.3_Missense_Mutation_p.I806M|HELLS_uc001kjt.3_Missense_Mutation_p.I822M|HELLS_uc009xul.3_Missense_Mutation_p.I724M|HELLS_uc009xum.3_Missense_Mutation_p.I692M|HELLS_uc009xun.3_Missense_Mutation_p.I698M|HELLS_uc001kju.3_Missense_Mutation_p.I461M|HELLS_uc009xup.3_Non-coding_Transcript|HELLS_uc009xuq.3_Missense_Mutation_p.I684M|HELLS_uc009xur.3_Non-coding_Transcript	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	Homo sapiens helicase, lymphoid-specific (HELLS), mRNA.	822					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		AGATGGGGATATTCAAGATAT	0.303000														50			9		0	0	1	0	0
AK094577	0	broad.mit.edu	37	8	145722929	145722929	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr8:145722929G>A	uc003zde.1	-	1	697	c.185C>T	c.(184-186)aCa>aTa	p.T62I	PPP1R16A_uc003zdd.3_Intron|PPP1R16A_uc003zdf.3_Intron					Homo sapiens cDNA FLJ37258 fis, clone BRAMY2010208.																		GGCTGGGCCTGTCCACAGCTC	0.677000														11			3		0	0	1	0	0
PIH1D2	120379	broad.mit.edu	37	11	111942472	111942472	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr11:111942472T>C	uc001pmp.4	-	2	411	c.188A>G	c.(187-189)gAa>gGa	p.E63G	PIH1D2_uc009yyl.3_Missense_Mutation_p.E63G|PIH1D2_uc010rws.1_Missense_Mutation_p.E63G|C11orf57_uc001pmu.2_5'Flank|C11orf57_uc001pmw.4_5'Flank|C11orf57_uc001pmr.4_5'Flank|C11orf57_uc001pmt.4_5'Flank|C11orf57_uc001pmv.4_5'Flank|C11orf57_uc001pms.4_5'Flank	NM_138789	NP_620144	Q8WWB5	PIHD2_HUMAN	Homo sapiens PIH1 domain containing 2 (PIH1D2), transcript variant 1, mRNA.	63										endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		AAGTATTTTTTCTTTTGGTTT	0.428000														23			10		0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152390825	152390825	+	Silent	SNP	G	A	A			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr2:152390825G>A	uc021vrb.1	-	113	16247	c.16218C>T	c.(16216-16218)taC>taT	p.Y5406Y	NEB_uc002txr.3_Silent_p.Y1872Y|NEB_uc002txu.3_Silent_p.Y7107Y|NEB_uc021vrc.1_Intron|NEB_uc010fnx.3_Silent_p.Y5394Y|NEB_uc021vrd.1_Silent_p.Y5406Y|NEB_uc002txt.4_5'Flank	NM_004543	NP_004534	P20929	NEBU_HUMAN	Homo sapiens nebulin (NEB), transcript variant 3, mRNA.	5406					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	Z disc|actin cytoskeleton|cytosol	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		AATCAGCTCTGTATTTTTTCT	0.443000														72			5		0	0	1	0	0
TSNAX	7257	broad.mit.edu	37	1	231696959	231696959	+	Silent	SNP	A	G	G			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr1:231696959A>G	uc001huw.3	+	4	611	c.453A>G	c.(451-453)caA>caG	p.Q151Q	DISC1_uc010pwe.2_5'UTR|DISC1_uc010pwf.2_Intron|DISC1_uc010pwj.1_5'UTR|DISC1_uc010pwk.1_5'UTR|DISC1_uc010pwg.1_Intron|DISC1_uc010pwh.1_5'UTR|DISC1_uc010pwi.1_5'UTR|DISC1_uc010pwl.2_Intron	NM_005999	NP_005990	Q99598	TSNAX_HUMAN	Homo sapiens translin-associated factor X (TSNAX), mRNA.	151	Interaction with C1D.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus|perinuclear region of cytoplasm	protein transporter activity|sequence-specific DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	9		all_cancers(173;0.0395)|Acute lymphoblastic leukemia(190;3.76e-06)|Prostate(94;0.116)				TTAATAAACAATTGATATTTA	0.289000														30			13		0	0	1	0	0
RIMS3	9783	broad.mit.edu	37	1	41098767	41098767	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr1:41098767C>T	uc001cfu.1	-	4	911	c.446G>A	c.(445-447)cGa>cAa	p.R149Q	RIMS3_uc001cfv.1_Missense_Mutation_p.R149Q	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	Homo sapiens regulating synaptic membrane exocytosis 3 (RIMS3), mRNA.	149					neurotransmitter transport	cell junction|synapse				NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			CAGTGTCTGTCGCCCCACAAT	0.592000														69			76		0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1267146	1267146	+	Silent	SNP	G	A	A			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr11:1267146G>A	uc001lta.3	+	30	9095	c.9036G>A	c.(9034-9036)ccG>ccA	p.P3012P		NM_002458	NP_002449	Q9HC84	MUC5B_HUMAN	Homo sapiens mucin 5B, oligomeric mucus/gel-forming (MUC5B), mRNA.	3012	17 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGGCCATCCCGTCCTCCACCC	0.642000														82			31		0	0	1	0	0
ANKRD5	63926	broad.mit.edu	37	20	10023795	10023795	+	Silent	SNP	G	A	A			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr20:10023795G>A	uc002wno.3	+	3	765	c.372G>A	c.(370-372)ccG>ccA	p.P124P	LOC100131208_uc002wnn.2_Intron|ANKRD5_uc002wnp.3_Silent_p.P124P|ANKRD5_uc010gbz.3_5'UTR	NM_022096	NP_942093	Q9NU02	ANKR5_HUMAN	Homo sapiens ankyrin repeat domain 5 (ANKRD5), transcript variant 1, mRNA.	124							calcium ion binding			breast(2)|endometrium(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	37						GCATTTTACCGACTAAGCGGC	0.378000														44			23		0	0	1	0	0
AXIN1	8312	broad.mit.edu	37	16	354424	354424	+	Silent	SNP	C	T	T			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr16:354424C>T	uc002cgp.2	-	4	1523	c.1134G>A	c.(1132-1134)ccG>ccA	p.P378P	LUC7L_uc021szo.1_Intron|AXIN1_uc002cgq.2_Silent_p.P378P	NM_003502	NP_003493	O15169	AXIN1_HUMAN	Homo sapiens axin 1 (AXIN1), transcript variant 1, mRNA.	378	Interaction with GSK3B (By similarity).				Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis|activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	GTPase activator activity|I-SMAD binding|armadillo repeat domain binding|beta-catenin binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding	p.P378L(1)|p.?(1)		biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GGACCTCCTTCGGCACCCGGT	0.627000														37			3		0	0	1	0	0
FAM83F	113828	broad.mit.edu	37	22	40417409	40417409	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr22:40417409G>A	uc003ayk.1	+	3	989	c.895G>A	c.(895-897)Gac>Aac	p.D299N		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	Homo sapiens family with sequence similarity 83, member F (FAM83F), mRNA.	299										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|skin(4)|urinary_tract(2)	14						CGAGGAGGTGGACTTGTACCG	0.592000														116			13		0	0	1	0	0
P4HB	5034	broad.mit.edu	37	17	79813410	79813410	+	Silent	SNP	C	A	A			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr17:79813410C>A	uc002kbn.1	-	2	602	c.405G>T	c.(403-405)ccG>ccT	p.P135P	P4HB_uc002kbm.1_5'UTR	NM_000918	NP_000909	P07237	PDIA1_HUMAN	Homo sapiens prolyl 4-hydroxylase, beta polypeptide (P4HB), mRNA.	135					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	ER-Golgi intermediate compartment|cell surface|endoplasmic reticulum lumen|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			NS(1)|breast(1)|large_intestine(2)|lung(17)|urinary_tract(1)	22	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			TGGTGGCAGCCGGGCCCGTGC	0.592000														50			3		0.004672	0.004672	1	1	0
ZNF407	55628	broad.mit.edu	37	18	72775591	72775592	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EM-A2CO-01A-11D-A19J-08	TCGA-EM-A2CO-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d31942ef-c251-4444-b743-3463827dc120	d4b5812a-ded5-47da-9681-0da4dac669c7	g.chr18:72775591_72775592insT	uc002llw.2	+	7	5967_5968	c.5914_5915insT	c.(5914-5916)attfs	p.I1972fs		NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	Homo sapiens zinc finger protein 407 (ZNF407), transcript variant 1, mRNA.	1972					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CAAGCAGGAGATTTTAAACCTC	0.614													---	7	---	---	6	---					
