Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDK11B	984	broad.mit.edu	37	1	1572104	1572104	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:1572104C>T	uc001agv.1	-	21	1968	c.1857G>A	c.(1855-1857)CTG>CTA	p.L619L	CDK11B_uc009vkj.2_Silent_p.L276L|CDK11B_uc001ags.1_Silent_p.L477L|CDK11B_uc001agt.1_Silent_p.L402L|CDK11B_uc001aha.1_Silent_p.L585L|CDK11B_uc001agw.1_Silent_p.L574L|CDK11B_uc001agy.1_Silent_p.L617L|CDK11B_uc001agx.1_Silent_p.L608L|CDK11B_uc001agz.1_Silent_p.L363L	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	632	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						GCTTCTGAGTCAGCAGCTCCC	0.587													8	80					0	0	0.004482	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724942	7724942	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:7724942G>A	uc001aoi.2	+	9	2542	c.2335G>A	c.(2335-2337)GAC>AAC	p.D779N		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCTGATCAACGACTTCATCTC	0.647													68	503					0	0	0.014410	0	0
PER3	8863	broad.mit.edu	37	1	7863155	7863155	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:7863155G>A	uc001aoo.2	+	8	1093	c.918G>A	c.(916-918)TCG>TCA	p.S306S	PER3_uc009vmg.1_Silent_p.S307S|PER3_uc009vmh.1_Silent_p.S307S|PER3_uc001aop.2_Silent_p.S307S|PER3_uc010nzw.1_5'UTR|PER3_uc001aon.2_Silent_p.S306S	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	306	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TTGGAACATCGATCCTAAGCT	0.448													9	106					0	0	0.004482	0	0
CSMD2	114784	broad.mit.edu	37	1	34180259	34180259	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:34180259C>G	uc001bxn.1	-	21	3243	c.3214G>C	c.(3214-3216)GAG>CAG	p.E1072Q	CSMD2_uc001bxm.1_Missense_Mutation_p.E1112Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1072	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCGGTGCCCTCCAGACGGTAC	0.642													41	274					0	0	0.013114	0	0
BSND	7809	broad.mit.edu	37	1	55464880	55464880	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:55464880C>T	uc001cye.2	+	1	264	c.21C>T	c.(19-21)TTC>TTT	p.F7F		NM_057176	NP_476517	Q8WZ55	BSND_HUMAN	barttin	7	Helical; (Potential).					basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				ovary(1)|skin(1)	2						AGAAGACCTTCCGGATCGGCT	0.617													32	96					0	0	0.011902	0	0
TUFT1	7286	broad.mit.edu	37	1	151534633	151534633	+	Missense_Mutation	SNP	G	A	A	rs139065608	byFrequency	TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:151534633G>A	uc001eyl.2	+	2	189	c.127G>A	c.(127-129)GCC>ACC	p.A43T	TUFT1_uc001eym.2_Intron|TUFT1_uc010pdf.1_Missense_Mutation_p.A62T|TUFT1_uc010pdg.1_Intron	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	43					bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGAACACATAGCCCAGAAGGT	0.517													15	120					0	0	0.004007	0	0
IFI16	3428	broad.mit.edu	37	1	159023487	159023487	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:159023487G>C	uc001ftg.2	+	10	2372	c.2082G>C	c.(2080-2082)TTG>TTC	p.L694F	IFI16_uc010pis.1_Missense_Mutation_p.L694F|IFI16_uc001fth.2_Missense_Mutation_p.L237F|IFI16_uc010pit.1_Missense_Mutation_p.L293F	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	750	HIN-200 2.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					CCGGGGAGTTGAGATCTGTAA	0.408													9	147					0	0	0.006214	0	0
ADORA1	134	broad.mit.edu	37	1	203134455	203134455	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:203134455C>T	uc001gze.1	+	4	841	c.408C>T	c.(406-408)TTC>TTT	p.F136F	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Silent_p.F136F|ADORA1_uc010pqg.1_Silent_p.F68F|ADORA1_uc009xak.1_Missense_Mutation_p.R62C|ADORA1_uc010pqh.1_Silent_p.F169F	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	136	Helical; Name=4; (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	TCCTCTCCTTCGTGGTGGGAC	0.652													11	44					0	0	0.016723	0	0
OPTC	26254	broad.mit.edu	37	1	203472794	203472794	+	Silent	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:203472794C>G	uc001gzu.1	+	7	1061	c.945C>G	c.(943-945)CTC>CTG	p.L315L		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	315	LRR 6.					proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			ACCTCAGCCTCTTCCCCAGCG	0.622													15	126					0	0	0.003163	0	0
FLVCR1	28982	broad.mit.edu	37	1	213032277	213032277	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:213032277C>T	uc001hjt.2	+	1	681	c.483C>T	c.(481-483)ATC>ATT	p.I161I	LQK1_uc001hjr.3_5'Flank|LQK1_uc001hjs.3_5'Flank	NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	161	Helical; (Potential).				cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		TGCCCCTCATCTTCCCGGCCA	0.627													17	157					0	0	0.010504	0	0
MTR	4548	broad.mit.edu	37	1	236973894	236973894	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:236973894C>T	uc001hyi.3	+	5	924	c.501C>T	c.(499-501)ATC>ATT	p.I167I	MTR_uc010pxv.1_RNA|MTR_uc010pxw.1_5'UTR|MTR_uc010pxx.1_Silent_p.I167I|MTR_uc010pxy.1_Silent_p.I167I|MTR_uc009xgj.1_5'UTR	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	167	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	ATAGGAACATCAGTGAGTAtt	0.264													28	89					0	0	0.004656	0	0
MASTL	84930	broad.mit.edu	37	10	27447546	27447546	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:27447546G>A	uc001itm.2	+	2	894	c.255G>A	c.(253-255)CTG>CTA	p.L85L	MASTL_uc001itl.2_Silent_p.L85L|MASTL_uc009xkw.1_Silent_p.L85L|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	85	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						GAGATGCACTGGCACTAAGCA	0.333													9	133					0	0	0.006214	0	0
FRMPD2	143162	broad.mit.edu	37	10	49414917	49414917	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:49414917C>G	uc001jgi.2	-	14	1778	c.1671G>C	c.(1669-1671)AGG>AGC	p.R557S	FRMPD2_uc001jgh.2_Missense_Mutation_p.R525S|FRMPD2_uc001jgj.2_Missense_Mutation_p.R535S	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	557	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CTTCTGGCCTCCTCTTCTCTG	0.488													30	44					0	0	0.007291	0	0
Unknown	0	broad.mit.edu	37	10	52389833	52389833	+	RNA	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:52389833G>C	uc001jjf.1	+	2		c.526G>C								Homo sapiens cDNA FLJ12320 fis, clone MAMMA1002082.																		TTTTGGATTTGACTTTCTGAG	0.438													4	17					0	0	0.009096	0	0
CTNNA3	29119	broad.mit.edu	37	10	68979522	68979522	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:68979522G>A	uc009xpn.1	-	6	809	c.686C>T	c.(685-687)TCT>TTT	p.S229F	CTNNA3_uc001jmw.2_Missense_Mutation_p.S229F|CTNNA3_uc001jmx.3_Missense_Mutation_p.S229F|CTNNA3_uc009xpo.1_Missense_Mutation_p.S89F|CTNNA3_uc001jna.2_Missense_Mutation_p.S241F	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	229					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						AGCAACATCAGAATGCTCCAA	0.418													22	109					0	0	0.014323	0	0
OIT3	170392	broad.mit.edu	37	10	74684331	74684331	+	Missense_Mutation	SNP	G	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:74684331G>T	uc001jte.1	+	7	1514	c.1296G>T	c.(1294-1296)TTG>TTT	p.L432F	OIT3_uc009xqs.1_Intron	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	432	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					TGGAAAGCTTGGTGGAGAGCT	0.557													14	66					7.93312e-07	8.09669e-07	0.020292	1	0
KCNMA1	3778	broad.mit.edu	37	10	78709021	78709021	+	Missense_Mutation	SNP	G	A	A	rs150678882		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:78709021G>A	uc001jxn.2	-	22	2765	c.2588C>T	c.(2587-2589)CCG>CTG	p.P863L	KCNMA1_uc001jxj.2_Missense_Mutation_p.P809L|KCNMA1_uc001jxk.1_Missense_Mutation_p.P481L|KCNMA1_uc009xrt.1_Missense_Mutation_p.P654L|KCNMA1_uc001jxl.1_Missense_Mutation_p.P488L|KCNMA1_uc001jxo.2_Missense_Mutation_p.P846L|KCNMA1_uc001jxm.2_Missense_Mutation_p.P805L|KCNMA1_uc001jxq.2_Missense_Mutation_p.P808L	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	863	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GGCACGGAGCGGCATCACCAG	0.552													18	87					0	0	0.004990	0	0
PTEN	5728	broad.mit.edu	37	10	89717615	89717615	+	Nonsense_Mutation	SNP	C	T	T	rs121909227		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:89717615C>T	uc001kfb.2	+	8	1671	c.640C>T	c.(640-642)CAG>TAG	p.Q214*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	214	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.Q214*(8)|p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.G165_K342del(1)|p.Q214fs*22(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGCAGATCCTCAGTTTGTGGT	0.388		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			40	97					0	0	0.009718	0	0
PDCD11	22984	broad.mit.edu	37	10	105201705	105201705	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:105201705G>A	uc001kwy.1	+	31	4767	c.4680G>A	c.(4678-4680)GAG>GAA	p.E1560E		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1560					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CAGACAGCGAGGAGGATGAGA	0.572													13	54					0	0	0.013537	0	0
HTRA1	5654	broad.mit.edu	37	10	124273839	124273839	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:124273839C>G	uc001lgj.2	+	9	1535	c.1407C>G	c.(1405-1407)ATC>ATG	p.I469M		NM_002775	NP_002766	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1 precursor	469					proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				ATGAAGATATCATGATCACAG	0.507													3	97					0	0	0.004672	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133930916	133930916	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:133930916G>C	uc001lkx.3	+	2	471	c.471G>C	c.(469-471)GAG>GAC	p.E157D		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TGCAGCAGGAGATCTCCGAGC	0.617													6	76					0	0	0.001984	0	0
ANO9	338440	broad.mit.edu	37	11	433372	433372	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:433372C>T	uc001lpi.2	-	4	377	c.292G>A	c.(292-294)GAG>AAG	p.E98K	ANO9_uc010qvv.1_5'UTR	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	98	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GCAGGCCCCTCAGGCTCCAGG	0.652													11	73					0	0	0.008291	0	0
CYB5R2	51700	broad.mit.edu	37	11	7687688	7687688	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:7687688G>A	uc001mfm.2	-	8	890	c.652C>T	c.(652-654)CCC>TCC	p.P218S	CYB5R2_uc001mfn.2_RNA|CYB5R2_uc009yfk.2_Missense_Mutation_p.P218S	NM_016229	NP_057313	Q6BCY4	NB5R2_HUMAN	cytochrome b5 reductase b5R.2	218					sterol biosynthetic process	membrane|soluble fraction	cytochrome-b5 reductase activity				0				Epithelial(150;5.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTACCAATGGGAGGCCTGTCC	0.483											OREG0020724	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	49					0	0	0.013537	0	0
OR5D16	390144	broad.mit.edu	37	11	55606854	55606854	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:55606854G>C	uc010rio.1	+	1	627	c.627G>C	c.(625-627)GAG>GAC	p.E209D		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				CTTTTAATGAGATAAGCACAC	0.433													15	112					0	0	0.003163	0	0
OR5W2	390148	broad.mit.edu	37	11	55681565	55681565	+	Missense_Mutation	SNP	C	T	T	rs148084259		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:55681565C>T	uc010rir.1	-	1	494	c.494G>A	c.(493-495)CGC>CAC	p.R165H		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAAGCATAGGCGGAAGGCCAG	0.428													9	80					0	0	0.006214	0	0
MS4A14	84689	broad.mit.edu	37	11	60183756	60183756	+	Missense_Mutation	SNP	G	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:60183756G>T	uc001npj.2	+	5	1880	c.1315G>T	c.(1315-1317)GAT>TAT	p.D439Y	MS4A14_uc001npi.2_Missense_Mutation_p.D327Y|MS4A14_uc001npn.2_Missense_Mutation_p.D177Y|MS4A14_uc001npk.2_Missense_Mutation_p.D422Y|MS4A14_uc001npl.2_Missense_Mutation_p.D177Y|MS4A14_uc001npm.2_Missense_Mutation_p.D177Y	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	439	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						GCAGCCCCCAGATCTTCAACC	0.333													12	82					2.27111e-07	2.39191e-07	0.013537	1	0
MARK2	2011	broad.mit.edu	37	11	63671484	63671484	+	Missense_Mutation	SNP	C	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:63671484C>A	uc001nxw.2	+	15	2120	c.1541C>A	c.(1540-1542)TCC>TAC	p.S514Y	MARK2_uc001nxx.2_Intron|MARK2_uc001nxy.2_Intron|MARK2_uc001nxv.3_Intron|MARK2_uc001nxz.3_Missense_Mutation_p.S480Y|MARK2_uc009yoy.2_Intron	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	514					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						TCCCGGGCCTCCACGGCTTCT	0.657													8	42					3.09899e-07	3.22947e-07	0.004482	1	0
ACTN3	89	broad.mit.edu	37	11	66330623	66330623	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:66330623G>A	uc001oio.1	+	22	2683	c.2665G>A	c.(2665-2667)GTG>ATG	p.V889M	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	889					focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						CCTGGACTACGTGGCCTTCTC	0.637													15	67					0	0	0.004990	0	0
UVRAG	7405	broad.mit.edu	37	11	75727987	75727987	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:75727987G>C	uc001oxc.2	+	12	1430	c.1189G>C	c.(1189-1191)GAC>CAC	p.D397H	UVRAG_uc010rrw.1_Missense_Mutation_p.D296H|UVRAG_uc001oxd.2_Missense_Mutation_p.D25H|UVRAG_uc010rrx.1_Missense_Mutation_p.D25H|UVRAG_uc009yuh.1_RNA	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	397					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						AACAATCAAAGACAATATCAA	0.353													13	96					0	0	0.016723	0	0
CASP5	838	broad.mit.edu	37	11	104866483	104866483	+	Silent	SNP	A	G	G	rs146387103		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:104866483A>G	uc010rva.1	-	9	1325	c.1293T>C	c.(1291-1293)TTT>TTC	p.F431F	CASP5_uc010ruz.1_Silent_p.F444F|CASP5_uc010rvb.1_Silent_p.F373F|CASP5_uc010rvc.1_Silent_p.F289F|CASP5_uc009yxh.2_Silent_p.F213F|CASP5_uc010rvd.1_Silent_p.F213F	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	431					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		AATTGCCAGGAAAGAGGTAGA	0.403													11	57					0	0	0.013537	0	0
RNF214	257160	broad.mit.edu	37	11	117109497	117109497	+	Silent	SNP	A	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:117109497A>C	uc001pqt.2	+	3	333	c.288A>C	c.(286-288)ACA>ACC	p.T96T	RNF214_uc001pqu.2_Silent_p.T96T|RNF214_uc010rxf.1_Intron	NM_207343	NP_997226	Q8ND24	RN214_HUMAN	ring finger protein 214	96							zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		TGATAGCCACAGCCCTTTGTC	0.537													19	130					0	0	0.007413	0	0
B3GAT1	27087	broad.mit.edu	37	11	134253724	134253724	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:134253724G>A	uc001qhq.2	-	4	732	c.471C>T	c.(469-471)GAC>GAT	p.D157D	B3GAT1_uc001qhr.2_Silent_p.D157D|B3GAT1_uc010scv.1_Silent_p.D170D	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	157	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		GGTCGCGGGCGTCTCCGCGCA	0.736													3	9					0	0	0.004672	0	0
AKAP3	10566	broad.mit.edu	37	12	4735979	4735979	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr12:4735979C>G	uc001qnb.3	-	4	2318	c.2089G>C	c.(2089-2091)GAT>CAT	p.D697H		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	697					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						GACTTGTCATCTCCCAGCTCT	0.502													6	57					0	0	0.001168	0	0
OR6C70	390327	broad.mit.edu	37	12	55863491	55863491	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr12:55863491G>A	uc010spn.1	-	1	432	c.432C>T	c.(430-432)TTC>TTT	p.F144F		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CCCAAGAACTGAATACAAGCT	0.388													21	54					0	0	0.012319	0	0
LRP1	4035	broad.mit.edu	37	12	57550035	57550035	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr12:57550035C>T	uc001snd.2	+	9	1852	c.1386C>T	c.(1384-1386)CTC>CTT	p.L462L		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	462	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GTGGTGCCCTCCACATCTACC	0.597													7	74					0	0	0.001984	0	0
XPOT	11260	broad.mit.edu	37	12	64824015	64824015	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr12:64824015G>A	uc001ssb.2	+	17	2350	c.1924G>A	c.(1924-1926)GAA>AAA	p.E642K		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	642	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		ACAAGATGAAGAAAGGCAAGC	0.393													12	39					0	0	0.013537	0	0
UTP20	27340	broad.mit.edu	37	12	101748657	101748657	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr12:101748657G>A	uc001tia.1	+	41	5311	c.5155G>A	c.(5155-5157)GAG>AAG	p.E1719K		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1719					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						CATGGAATTAGAGCGTGTGGA	0.438													9	67					0	0	0.006214	0	0
RPH3A	22895	broad.mit.edu	37	12	113266130	113266130	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr12:113266130G>C	uc010syl.1	+	3	369	c.7G>C	c.(7-9)GAC>CAC	p.D3H	RPH3A_uc001ttz.2_Missense_Mutation_p.D3H|RPH3A_uc001tty.2_Missense_Mutation_p.D3H|RPH3A_uc009zwe.1_Missense_Mutation_p.D3H|RPH3A_uc010sym.1_Missense_Mutation_p.D3H	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	3					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		TACTATGACTGACACCGTGTT	0.483													11	66					0	0	0.013537	0	0
OAS1	4938	broad.mit.edu	37	12	113354509	113354509	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr12:113354509G>A	uc001tud.2	+	4	956	c.850G>A	c.(850-852)GAA>AAA	p.E284K	OAS1_uc010syn.1_Missense_Mutation_p.E283K|OAS1_uc010syo.1_3'UTR|OAS1_uc001tub.2_Missense_Mutation_p.E284K|OAS1_uc001tuc.2_Missense_Mutation_p.E284K|OAS1_uc009zwf.2_Missense_Mutation_p.E283K	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	284					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2						CCCCATTATTGAAAAGTACCT	0.453													26	78					0	0	0.005443	0	0
NUPL1	9818	broad.mit.edu	37	13	25894700	25894700	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr13:25894700C>G	uc001uqi.2	+	8	989	c.743C>G	c.(742-744)CCT>CGT	p.P248R	NUPL1_uc001uqg.1_Missense_Mutation_p.P248R|NUPL1_uc001uqj.2_Missense_Mutation_p.P236R	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	248	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		GAAAATCTACCTCCTGTCATC	0.323													7	50					0	0	0.006214	0	0
HSPH1	10808	broad.mit.edu	37	13	31724198	31724198	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr13:31724198C>T	uc001utj.2	-	8	1428	c.1030G>A	c.(1030-1032)GCT>ACT	p.A344T	HSPH1_uc001utk.2_Missense_Mutation_p.A344T|HSPH1_uc010aaw.2_Missense_Mutation_p.A303T|HSPH1_uc001utl.2_Missense_Mutation_p.A346T|HSPH1_uc010tds.1_Missense_Mutation_p.A268T|HSPH1_uc010tdt.1_RNA	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	344					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		ATTCGTGTAGCGCCTCCAACA	0.418													43	95					0	0	0.009718	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679276	37679276	+	Missense_Mutation	SNP	C	T	T	rs112114979		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr13:37679276C>T	uc001uwm.1	-	1	526	c.118G>A	c.(118-120)GGC>AGC	p.G40S		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	40	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		ACGTCCTCGCCGTTGGTGGTG	0.532													8	118					0	0	0.003080	0	0
THSD1	55901	broad.mit.edu	37	13	52972113	52972113	+	Missense_Mutation	SNP	T	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr13:52972113T>C	uc001vgo.2	-	3	820	c.275A>G	c.(274-276)TAT>TGT	p.Y92C	THSD1_uc001vgp.2_Missense_Mutation_p.Y92C|THSD1_uc010tgz.1_Intron|THSD1_uc010aea.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	92	Extracellular (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CTCCTTGAAATAGAAGCACTC	0.493													14	98					0	0	0.016723	0	0
SCEL	8796	broad.mit.edu	37	13	78176203	78176203	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr13:78176203C>T	uc001vki.2	+	16	1091	c.921C>T	c.(919-921)ATC>ATT	p.I307I	SCEL_uc001vkj.2_Silent_p.I287I|SCEL_uc010thx.1_Silent_p.I285I	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	307	16 X approximate tandem repeats.|4.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		TGTAAAGAATCCAAAGCCTTG	0.393													6	63					0	0	0.003080	0	0
ARID4A	5926	broad.mit.edu	37	14	58817911	58817911	+	Missense_Mutation	SNP	A	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr14:58817911A>G	uc001xdp.2	+	16	1779	c.1525A>G	c.(1525-1527)ACT>GCT	p.T509A	ARID4A_uc001xdo.2_Missense_Mutation_p.T509A|ARID4A_uc001xdq.2_Missense_Mutation_p.T509A|ARID4A_uc010apg.1_Missense_Mutation_p.T187A	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	509					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						TGACTATGAAACTGCAGAGAA	0.299													32	78					0	0	0.012213	0	0
SYNE2	23224	broad.mit.edu	37	14	64599109	64599109	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr14:64599109G>C	uc001xgm.2	+	77	14697	c.14467G>C	c.(14467-14469)GAA>CAA	p.E4823Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E4823Q|SYNE2_uc010apy.2_Missense_Mutation_p.E1208Q|SYNE2_uc010apz.1_Missense_Mutation_p.E715Q	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4823	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TAAAATACTAGAAGAAAAGTC	0.383													6	106					0	0	0.001984	0	0
ALDH6A1	4329	broad.mit.edu	37	14	74534264	74534264	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr14:74534264C>T	uc001xpo.2	-	8	960	c.861G>A	c.(859-861)AAG>AAA	p.K287K	C14orf45_uc001xpm.1_Intron|ALDH6A1_uc010asa.2_Silent_p.K132K|ALDH6A1_uc010tuq.1_Silent_p.K274K	NM_005589	NP_005580	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6A1 precursor	287						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	CCCCATGGTTCTTGGCTCCCT	0.418													11	81					0	0	0.013537	0	0
AK7	122481	broad.mit.edu	37	14	96858567	96858567	+	Missense_Mutation	SNP	G	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr14:96858567G>T	uc001yfn.2	+	1	120	c.76G>T	c.(76-78)GAT>TAT	p.D26Y	AK7_uc001yfm.1_Missense_Mutation_p.D26Y	NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	26					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		AAACCTGTTGGATTCCTACAG	0.617													6	24					5.9392e-07	6.1248e-07	0.001168	1	0
TUBGCP4	27229	broad.mit.edu	37	15	43663591	43663591	+	Silent	SNP	T	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr15:43663591T>C	uc001zro.2	+	1	279	c.39T>C	c.(37-39)CCT>CCC	p.P13P	ZSCAN29_uc001zrj.1_5'Flank|ZSCAN29_uc001zrk.1_5'Flank|ZSCAN29_uc010bdf.1_5'Flank|ZSCAN29_uc001zrl.1_5'Flank|ZSCAN29_uc010bdg.1_5'Flank|ZSCAN29_uc001zrm.2_5'Flank|TUBGCP4_uc001zrn.2_Silent_p.P13P	NM_014444	NP_055259	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	13					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		GCGGGTACCCTGGGTCCATTT	0.657											OREG0023087	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	56					0	0	0.014758	0	0
TSC2	7249	broad.mit.edu	37	16	2106737	2106737	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr16:2106737C>T	uc002con.2	+	8	847	c.741C>T	c.(739-741)ATC>ATT	p.I247I	TSC2_uc010bsd.2_Silent_p.I247I|TSC2_uc002coo.2_Silent_p.I247I|TSC2_uc010uvv.1_Silent_p.I210I|TSC2_uc010uvw.1_Silent_p.I198I|TSC2_uc002cop.2_Silent_p.I47I	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	247	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GTCGCACCATCAACGTCAAGG	0.597			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				21	195					0	0	0.004656	0	0
PARN	5073	broad.mit.edu	37	16	14540804	14540804	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr16:14540804G>A	uc010uzd.1	-	23	1947	c.1805C>T	c.(1804-1806)TCA>TTA	p.S602L	PARN_uc010uzc.1_Missense_Mutation_p.S541L|PARN_uc010uze.1_Missense_Mutation_p.S556L|PARN_uc010uzf.1_Missense_Mutation_p.S427L	NM_002582	NP_002573	O95453	PARN_HUMAN	poly(A)-specific ribonuclease (deadenylation	602					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2						CCTTCCCTCTGAGAGGGGCTC	0.512													16	97					0	0	0.004007	0	0
XYLT1	64131	broad.mit.edu	37	16	17232374	17232374	+	Silent	SNP	C	T	T	rs138560456	by1000genomes	TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr16:17232374C>T	uc002dfa.2	-	8	1687	c.1602G>A	c.(1600-1602)ACG>ACA	p.T534T		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	534	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						TCTCCAGGACCGTATGGAAGA	0.502													13	65					0	0	0.003163	0	0
CMTM4	146223	broad.mit.edu	37	16	66670350	66670350	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr16:66670350G>A	uc002epz.2	-	2	503	c.321C>T	c.(319-321)CTC>CTT	p.L107L	CMTM4_uc002eqa.2_Silent_p.L107L	NM_178818	NP_848933	Q8IZR5	CKLF4_HUMAN	chemokine-like factor superfamily 4 isoform 1	107	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			pancreas(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0811)|Epithelial(162;0.214)		TGTGCAGGTTGAGACTGAACA	0.522													10	54					0	0	0.008291	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76528870	76528870	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr16:76528870C>G	uc002feu.1	+	16	2529	c.2144C>G	c.(2143-2145)TCT>TGT	p.S715C	CNTNAP4_uc002fev.1_Missense_Mutation_p.S579C|CNTNAP4_uc010chb.1_Missense_Mutation_p.S642C|CNTNAP4_uc002fex.1_Missense_Mutation_p.S718C|CNTNAP4_uc002few.2_Missense_Mutation_p.S690C	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	715	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TGGGGAGGTTCTTCGCCTGAT	0.413													14	142					0	0	0.020292	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76528926	76528926	+	Missense_Mutation	SNP	C	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr16:76528926C>A	uc002feu.1	+	16	2585	c.2200C>A	c.(2200-2202)CAG>AAG	p.Q734K	CNTNAP4_uc002fev.1_Missense_Mutation_p.Q598K|CNTNAP4_uc010chb.1_Missense_Mutation_p.Q661K|CNTNAP4_uc002fex.1_Missense_Mutation_p.Q737K|CNTNAP4_uc002few.2_Missense_Mutation_p.Q709K	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	734	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CATTGATTCTCAGTATTACTG	0.373													23	142					1.64293e-13	1.74893e-13	0.018920	1	0
SCARF1	8578	broad.mit.edu	37	17	1548203	1548203	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:1548203G>C	uc002fsz.1	-	3	240	c.190C>G	c.(190-192)CAG>GAG	p.Q64E	SCARF1_uc002fsy.1_Missense_Mutation_p.Q64E|SCARF1_uc002fta.1_RNA|SCARF1_uc010cjv.1_Missense_Mutation_p.Q64E	NM_003693	NP_003684	Q14162	SREC_HUMAN	scavenger receptor class F, member 1 isoform 1	64	EGF-like 1.|Extracellular (Potential).				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TCGTCTTTCTGGCAGGCGTCC	0.622													5	24					0	0	0.014758	0	0
ZZEF1	23140	broad.mit.edu	37	17	3917760	3917760	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:3917760G>A	uc002fxe.2	-	50	8259	c.8195C>T	c.(8194-8196)TCT>TTT	p.S2732F	ZZEF1_uc002fxg.1_Missense_Mutation_p.S53F	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2732							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTTGCACTGAGAGTCGAATTT	0.493													11	135					0	0	0.008291	0	0
DHX33	56919	broad.mit.edu	37	17	5359354	5359354	+	Missense_Mutation	SNP	T	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:5359354T>C	uc002gca.2	-	5	1000	c.998A>G	c.(997-999)TAT>TGT	p.Y333C	DHX33_uc002gbz.2_Missense_Mutation_p.Y104C|DHX33_uc002gcb.2_Missense_Mutation_p.Y160C|DHX33_uc010clf.2_Silent_p.L146L	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	333	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						CTGCTGTGCATAGGGCAGGGA	0.612													24	53					0	0	0.016522	0	0
MED31	51003	broad.mit.edu	37	17	6553727	6553727	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:6553727G>A	uc002gdg.3	-	2	161	c.55C>T	c.(55-57)CAG>TAG	p.Q19*	MED31_uc002gdh.3_RNA|C17orf100_uc010clp.1_5'Flank	NM_016060	NP_057144	Q9Y3C7	MED31_HUMAN	mediator of RNA polymerase II transcription,	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding				0						AACTCCAACTGAAACCGAAGT	0.348													35	107					0	0	0.019004	0	0
KDM6B	23135	broad.mit.edu	37	17	7752018	7752018	+	Silent	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:7752018C>G	uc002giw.1	+	11	2788	c.2412C>G	c.(2410-2412)CTC>CTG	p.L804L	KDM6B_uc002gix.2_Silent_p.L106L	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	804	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCAGCCTGCTCAAATCCTTGG	0.363													13	76					0	0	0.013537	0	0
CDK5R1	8851	broad.mit.edu	37	17	30815055	30815055	+	Silent	SNP	C	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:30815055C>A	uc002hhn.2	+	2	638	c.417C>A	c.(415-417)CCC>CCA	p.P139P	CDK5R1_uc010wca.1_Silent_p.P139P|CDK5R1_uc010ctc.2_5'UTR	NM_003885	NP_003876	Q15078	CD5R1_HUMAN	cyclin-dependent kinase 5, regulatory subunit 1	139					axon guidance|axonal fasciculation|brain development|cell proliferation|embryo development|ionotropic glutamate receptor signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of transcription, DNA-dependent|neuron cell-cell adhesion|neuron migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of neuron apoptosis|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation	axon|contractile fiber|cyclin-dependent protein kinase 5 holoenzyme complex|cytosol|dendritic spine|growth cone|neuromuscular junction|neuronal cell body|perinuclear region of cytoplasm|plasma membrane	cadherin binding|calcium ion binding|protein kinase binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.0938)			CAGGGACGCCCAAACGGGTCA	0.687													25	93					1.85244e-09	1.96141e-09	0.018920	1	0
TOP2A	7153	broad.mit.edu	37	17	38556817	38556817	+	Silent	SNP	A	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:38556817A>G	uc002huq.2	-	22	2889	c.2763T>C	c.(2761-2763)ATT>ATC	p.I921I		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	921					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	CTGAGATTTCAATGGTTGTAG	0.353													4	23					0	0	0.009096	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274424	39274424	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:39274424G>C	uc002hvz.2	-	1	183	c.144C>G	c.(142-144)AGC>AGG	p.S48R		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	48	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].|5.		Missing (in allele KAP4.14).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCCTGCAGCAGCTGGACACAC	0.672													5	63					0	0	0.004482	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40837369	40837369	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:40837369G>A	uc002iay.2	+	5	862	c.646G>A	c.(646-648)GAG>AAG	p.E216K	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	216	Laminin G-like 1.|Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GCTGCACGCCGAGGGCGCCCA	0.662													25	56					0	0	0.021523	0	0
MPP2	4355	broad.mit.edu	37	17	41956724	41956724	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:41956724G>A	uc010wip.1	-	12	1593	c.1536C>T	c.(1534-1536)TTC>TTT	p.F512F	MPP2_uc002ien.1_Silent_p.F484F|MPP2_uc010wim.1_Silent_p.F456F|MPP2_uc002ieo.1_Silent_p.F467F|MPP2_uc010win.1_Silent_p.F328F|MPP2_uc010wio.1_Silent_p.F456F	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	491	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		GGGCCTCGATGAACACCACGT	0.582													27	126					0	0	0.021523	0	0
PRR15L	79170	broad.mit.edu	37	17	46030367	46030367	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:46030367C>T	uc002imp.2	-	2	351	c.234G>A	c.(232-234)GAG>GAA	p.E78E		NM_024320	NP_077296	Q9BU68	PR15L_HUMAN	ATPase family, AAA domain containing 4	78										ovary(1)	1						CTTTCTTCTTCTCCTTGAAGC	0.537													6	180					0	0	0.001168	0	0
ABCA10	10349	broad.mit.edu	37	17	67171601	67171601	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr17:67171601C>G	uc010dfa.1	-	24	3702	c.2823G>C	c.(2821-2823)TTG>TTC	p.L941F	ABCA10_uc010wqs.1_5'UTR|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	941	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					AGTTTGTGATCAACAACAAAA	0.358													15	67					0	0	0.007413	0	0
CETN1	1068	broad.mit.edu	37	18	580567	580567	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr18:580567G>A	uc002kko.1	+	1	201	c.159G>A	c.(157-159)CTG>CTA	p.L53L		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	53	EF-hand 1.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						CGAAGGAGCTGAAGGTGGCCA	0.557													10	62					0	0	0.008291	0	0
ROCK1	6093	broad.mit.edu	37	18	18571139	18571139	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr18:18571139C>G	uc002kte.2	-	18	3082	c.2141G>C	c.(2140-2142)TGT>TCT	p.C714S		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	714	Glu-rich.|Interaction with FHOD1.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					ACACTTACCACACATTGCCAC	0.318													4	112					0	0	0.014758	0	0
LAMA3	3909	broad.mit.edu	37	18	21529761	21529761	+	Silent	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr18:21529761G>C	uc002kuq.2	+	71	9470	c.9384G>C	c.(9382-9384)CTG>CTC	p.L3128L	LAMA3_uc002kur.2_Silent_p.L3072L|LAMA3_uc002kus.3_Silent_p.L1519L|LAMA3_uc002kut.3_Silent_p.L1463L	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	3128	Laminin G-like 4.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGGATGCCTGAAGAACTTTC	0.483													4	104					0	0	0.009096	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561319	44561319	+	Missense_Mutation	SNP	T	C	C	rs146911955	byFrequency	TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr18:44561319T>C	uc002lcr.1	-	1	670	c.317A>G	c.(316-318)CAG>CGG	p.Q106R	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	106					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GGCCTTTTCCTGGTCCTGAAG	0.652													6	139					0	0	0.001984	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561321	44561321	+	Missense_Mutation	SNP	G	C	C	rs138936821	byFrequency	TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr18:44561321G>C	uc002lcr.1	-	1	668	c.315C>G	c.(313-315)GAC>GAG	p.D105E	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	105					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCTTTTCCTGGTCCTGAAGAG	0.662													6	142					0	0	0.001984	0	0
DYM	54808	broad.mit.edu	37	18	46860222	46860222	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr18:46860222C>G	uc002ldi.1	-	7	861	c.496G>C	c.(496-498)GAT>CAT	p.D166H	DYM_uc010xdf.1_Intron|DYM_uc002ldj.3_5'UTR	NM_017653	NP_060123	Q7RTS9	DYM_HUMAN	dymeclin	166						Golgi apparatus					0						TATGTAATATCTCTAAAATGG	0.313													5	74					0	0	0.001984	0	0
CPLX4	339302	broad.mit.edu	37	18	56964111	56964111	+	Missense_Mutation	SNP	T	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr18:56964111T>G	uc002lhy.2	-	3	489	c.302A>C	c.(301-303)GAT>GCT	p.D101A		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	101					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				TTCAGGTAAATCCACATCATC	0.358													8	76					0	0	0.008291	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60017106	60017106	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr18:60017106G>A	uc002lin.2	+	3	257	c.219G>A	c.(217-219)CCG>CCA	p.P73P	TNFRSF11A_uc010dpv.2_Silent_p.P73P	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	73	TNFR-Cys 2.|Extracellular (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				CCTGTGGCCCGGATGAATACT	0.418									Paget_Disease_of_Bone				30	166					0	0	0.007291	0	0
PCSK4	54760	broad.mit.edu	37	19	1487169	1487169	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr19:1487169G>A	uc002ltb.1	-	7	888	c.826C>T	c.(826-828)CGC>TGC	p.R276C	PCSK4_uc002lta.2_Missense_Mutation_p.R88C	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	276	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGGCCTCGCGGGTGAGGATG	0.721													10	30					0	0	0.010729	0	0
FBXW9	84261	broad.mit.edu	37	19	12800192	12800192	+	Silent	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr19:12800192G>C	uc010dyx.2	-	9	1356	c.1356C>G	c.(1354-1356)CTC>CTG	p.L452L	FBXW9_uc010xmp.1_RNA|uc002mul.1_3'UTR|FBXW9_uc002mum.1_Silent_p.L432L|FBXW9_uc002mun.1_Silent_p.L269L	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	462	WD 7.						protein binding			ovary(1)	1						TTACCCTATTGAGCCCATTGT	0.622													15	41					0	0	0.003163	0	0
F2RL3	9002	broad.mit.edu	37	19	17001392	17001392	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr19:17001392G>A	uc002nfa.2	+	2	1293	c.1118G>A	c.(1117-1119)GGC>GAC	p.G373D		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	373	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						GCGGAAGGGGGCAGCCGGGGC	0.527													3	18					0	0	0.014758	0	0
NFKBID	84807	broad.mit.edu	37	19	36381329	36381329	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr19:36381329G>A	uc002oci.1	-	10	1244	c.670C>T	c.(670-672)CAG>TAG	p.Q224*	NFKBID_uc002och.1_Nonsense_Mutation_p.Q61*|NFKBID_uc002ocj.1_Nonsense_Mutation_p.Q239*	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene	224	ANK 5.				inflammatory response	nucleus					0						AGCAGCAGCTGAACCAGAGTG	0.612													48	110					0	0	0.014410	0	0
SUPT5H	6829	broad.mit.edu	37	19	39965349	39965349	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr19:39965349C>T	uc002olo.3	+	28	3194	c.3015C>T	c.(3013-3015)CGC>CGT	p.R1005R	SUPT5H_uc002olp.3_Silent_p.R1005R|SUPT5H_uc002olq.3_Silent_p.R1001R|SUPT5H_uc002oln.3_Silent_p.R1005R|SUPT5H_uc002olr.3_Silent_p.R1005R|SUPT5H_uc002ols.1_Silent_p.R628R	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	1005					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GTGTCATCCGCAGTGTCACGG	0.498													6	34					0	0	0.001168	0	0
B3GNT8	374907	broad.mit.edu	37	19	41932155	41932155	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr19:41932155C>G	uc002oqs.2	-	3	983	c.529G>C	c.(529-531)GGG>CGG	p.G177R	CYP2F1_uc010xvw.1_Intron|B3GNT8_uc002oqt.1_Intron	NM_198540	NP_940942	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal	177	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity				0						AGCCGGATCCCTGGAGCTGGA	0.622													10	124					0	0	0.010729	0	0
PNMAL1	55228	broad.mit.edu	37	19	46974130	46974130	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr19:46974130C>T	uc002peq.3	-	2	469	c.163G>A	c.(163-165)GTG>ATG	p.V55M	PNMAL1_uc002per.3_Missense_Mutation_p.V55M	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	55											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ttgttgagcacgcggtacggg	0													7	98					0	0	0.001984	0	0
KIR2DL3	3804	broad.mit.edu	37	19	55263156	55263156	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr19:55263156C>T	uc002qgv.2	+	6	789	c.771C>T	c.(769-771)TTC>TTT	p.F257F	KIR2DL3_uc002qgx.2_Silent_p.F257F|KIR2DL3_uc002qgy.2_Silent_p.F159F|KIR2DL3_uc010erw.1_Silent_p.F257F|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron	NM_015868	NP_056952	P43628	KI2L3_HUMAN	killer cell immunoglobulin-like receptor, two	257	Helical; (Potential).				immune response|regulation of immune response	integral to plasma membrane	antigen binding|protein binding|receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		tcatcctcttcatcctcctcc	0.408													20	116					0	0	0.010504	0	0
ZNF776	284309	broad.mit.edu	37	19	58265724	58265724	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr19:58265724G>A	uc002qpx.2	+	3	1449	c.1226G>A	c.(1225-1227)TGT>TAT	p.C409Y	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Missense_Mutation_p.C409Y	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	409	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		TGTAAAGAATGTAGGAAATCA	0.428													9	103					0	0	0.004482	0	0
SNTG2	54221	broad.mit.edu	37	2	1271197	1271197	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:1271197G>C	uc002qwq.2	+	14	1266	c.1138G>C	c.(1138-1140)GAC>CAC	p.D380H	SNTG2_uc010ewi.2_Missense_Mutation_p.D253H	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	380	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		TCAAGATTTTGACTTTGAGGA	0.527													3	19					0	0	0.004672	0	0
MFSD2B	388931	broad.mit.edu	37	2	24247079	24247079	+	Silent	SNP	C	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:24247079C>A	uc002reo.1	+	13	1442	c.1428C>A	c.(1426-1428)CTC>CTA	p.L476L		NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	476	Helical; (Potential).				transport	integral to membrane				ovary(2)	2						TCTGCATCCTCATGGTCGGCT	0.652													10	33					7.48243e-07	7.67627e-07	0.006214	1	0
LHCGR	3973	broad.mit.edu	37	2	48950793	48950793	+	Silent	SNP	C	T	T	rs142554296		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:48950793C>T	uc002rwu.3	-	5	496	c.426G>A	c.(424-426)ACG>ACA	p.T142T	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	142	LRR 2.|Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AGAAGACCTTCGTAACATCTG	0.393									Familial_Male-Limited_Precocious_Puberty				9	92					0	0	0.008291	0	0
EMX1	2016	broad.mit.edu	37	2	73145356	73145356	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:73145356C>T	uc002sin.1	+	1	753	c.375C>T	c.(373-375)CAC>CAT	p.H125H	EMX1_uc002sim.1_Intron	NM_004097	NP_004088	Q04741	EMX1_HUMAN	empty spiracles homolog 1	92						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCATGAACCACCCCGCGCTGA	0.607													4	30					0	0	0.009096	0	0
TBC1D8	11138	broad.mit.edu	37	2	101646213	101646213	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:101646213G>A	uc010fiv.2	-	12	2048	c.1917C>T	c.(1915-1917)TTC>TTT	p.F639F	TBC1D8_uc002tau.3_Silent_p.F396F	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	639	Rab-GAP TBC.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						TGAGCTCCTCGAAGACAGACT	0.547													6	99					0	0	0.003080	0	0
SPOPL	339745	broad.mit.edu	37	2	139318393	139318393	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:139318393G>A	uc002tvh.2	+	8	1133	c.733G>A	c.(733-735)GAT>AAT	p.D245N		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	245	BTB.					nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GGAAATAAATGATTTAGACCC	0.333													6	85					0	0	0.001168	0	0
XIRP2	129446	broad.mit.edu	37	2	168107674	168107674	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:168107674G>A	uc002udx.2	+	8	9790	c.9772G>A	c.(9772-9774)GCT>ACT	p.A3258T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.A3083T|XIRP2_uc010fpq.2_Missense_Mutation_p.A3036T|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3083					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATCTGTGGACGCTCAAGAGGA	0.408													13	72					0	0	0.013537	0	0
TTN	7273	broad.mit.edu	37	2	179462709	179462709	+	Missense_Mutation	SNP	A	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:179462709A>G	uc010zfg.1	-	242	49708	c.49484T>C	c.(49483-49485)GTT>GCT	p.V16495A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V10190A|TTN_uc010zfi.1_Missense_Mutation_p.V10123A|TTN_uc010zfj.1_Missense_Mutation_p.V9998A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17422							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTGCTCTAACTCTAAATTT	0.398													26	122					0	0	0.005443	0	0
SLC39A10	57181	broad.mit.edu	37	2	196573389	196573389	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:196573389G>A	uc002utg.3	+	5	1610	c.1396G>A	c.(1396-1398)GGA>AGA	p.G466R	SLC39A10_uc002uth.3_Missense_Mutation_p.G466R|SLC39A10_uc010zgp.1_Missense_Mutation_p.G16R	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	466	His-rich.				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			GTCTCAGGGTGGACATGATCA	0.299													10	55					0	0	0.010729	0	0
HECW2	57520	broad.mit.edu	37	2	197085612	197085612	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:197085612C>T	uc002utm.1	-	25	4383	c.4200G>A	c.(4198-4200)AAG>AAA	p.K1400K	HECW2_uc002utl.1_Silent_p.K1044K	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1400	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CCTTCTTGTTCTTCTCTGTAA	0.413													28	176					0	0	0.008361	0	0
CCL20	6364	broad.mit.edu	37	2	228678700	228678700	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:228678700G>C	uc002vpl.2	+	1	143	c.73G>C	c.(73-75)GAA>CAA	p.E25Q	CCL20_uc002vpm.2_Missense_Mutation_p.E25Q	NM_004591	NP_004582	P78556	CCL20_HUMAN	chemokine (C-C motif) ligand 20 isoform 1	25					cell-cell signaling|chemotaxis|defense response to bacterium|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity				0		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;7.3e-11)|all cancers(144;4.13e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		CGGCGAATCAGAAGGTAAGTG	0.473													7	96					0	0	0.003080	0	0
KIF3B	9371	broad.mit.edu	37	20	30898226	30898226	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr20:30898226C>G	uc002wxq.2	+	2	813	c.646C>G	c.(646-648)CAT>GAT	p.H216D	KIF3B_uc010ztv.1_Missense_Mutation_p.H216D|KIF3B_uc010ztw.1_Missense_Mutation_p.H216D	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	216	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTCGCGTTCTCATGCAATTTT	0.488													10	106					0	0	0.008291	0	0
KIF3B	9371	broad.mit.edu	37	20	30898491	30898491	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr20:30898491C>G	uc002wxq.2	+	2	1078	c.911C>G	c.(910-912)TCC>TGC	p.S304C	KIF3B_uc010ztv.1_Missense_Mutation_p.S304C|KIF3B_uc010ztw.1_Missense_Mutation_p.S304C	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	304	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTCCAAGATTCCCTTGGTGGC	0.532													4	100					0	0	0.009096	0	0
CEP250	11190	broad.mit.edu	37	20	34059961	34059961	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr20:34059961C>G	uc002xcm.2	+	12	1706	c.1035C>G	c.(1033-1035)ATC>ATG	p.I345M	CEP250_uc010zve.1_Translation_Start_Site|CEP250_uc010zvd.1_RNA	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	345	Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			AGCAGGTGATCAAGGATATAA	0.463													8	191					0	0	0.004482	0	0
CDH4	1002	broad.mit.edu	37	20	60511902	60511902	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr20:60511902C>T	uc002ybn.1	+	16	2666	c.2652C>T	c.(2650-2652)AAC>AAT	p.N884N	CDH4_uc002ybp.1_Silent_p.N810N|uc002ybr.1_5'Flank	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	884	Ser-rich.|Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GCTCCCTGAACTCATCCAGTT	0.607													12	47					0	0	0.010729	0	0
KRTAP19-1	337882	broad.mit.edu	37	21	31852582	31852582	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr21:31852582C>G	uc011acx.1	-	1	55	c.55G>C	c.(55-57)GGT>CGT	p.G19R		NM_181607	NP_853638	Q8IUB9	KR191_HUMAN	keratin associated protein 19-1	19	26 X 2 AA repeats of G-[YCGS].					intermediate filament					0						CCCAGGCCACCGAAGCCTCCA	0.572													6	101					0	0	0.008871	0	0
IFNAR1	3454	broad.mit.edu	37	21	34721581	34721581	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr21:34721581G>C	uc002yrn.2	+	7	1120	c.973G>C	c.(973-975)GAT>CAT	p.D325H	IFNAR1_uc011adv.1_Missense_Mutation_p.D256H	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	325	Fibronectin type-III 2.|Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GATAAAGTTTGATACTGAAAT	0.323													10	86					0	0	0.006214	0	0
DIP2A	23181	broad.mit.edu	37	21	47918525	47918525	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr21:47918525C>T	uc002zjo.2	+	5	617	c.434C>T	c.(433-435)TCT>TTT	p.S145F	DIP2A_uc011afy.1_Missense_Mutation_p.S81F|DIP2A_uc011afz.1_Missense_Mutation_p.S145F|DIP2A_uc002zjl.2_Missense_Mutation_p.S145F|DIP2A_uc002zjm.2_Missense_Mutation_p.S145F|DIP2A_uc010gql.2_Missense_Mutation_p.S145F|DIP2A_uc002zjn.2_Missense_Mutation_p.S145F	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	145					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GATGAGGGCTCTTTACGGCGA	0.587													6	278					0	0	0.001984	0	0
ARVCF	421	broad.mit.edu	37	22	19965082	19965082	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr22:19965082G>A	uc002zqz.2	-	9	1997	c.1726C>T	c.(1726-1728)CGG>TGG	p.R576W	ARVCF_uc002zqy.2_Missense_Mutation_p.R98W	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	576	ARM 6.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					GACAGGTTCCGCATGATGCAC	0.682													19	130					0	0	0.007413	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30688746	30688746	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr22:30688746C>T	uc011akt.1	-	11	1169	c.1145G>A	c.(1144-1146)CGC>CAC	p.R382H	GATSL3_uc003ahf.2_Intron|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_Intron|TBC1D10A_uc003ahj.3_Missense_Mutation_p.R294H|TBC1D10A_uc010gvu.2_Missense_Mutation_p.R389H|TBC1D10A_uc003ahk.3_Missense_Mutation_p.R382H	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	382						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						GGGCGGGGAGCGGCACTGCAG	0.647													8	55					0	0	0.003080	0	0
TDGF1	6997	broad.mit.edu	37	3	46621265	46621265	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr3:46621265G>A	uc003cpv.2	+	4	540	c.260G>A	c.(259-261)GGA>GAA	p.G87E	LRRC2_uc003cpu.3_Intron	NM_003212	NP_003203	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	87	EGF-like.				activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		CTGAATGGGGGAACCTGCATG	0.532													29	188					0	0	0.009535	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50404872	50404872	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr3:50404872C>T	uc003daq.2	-	28	2413	c.2375G>A	c.(2374-2376)CGC>CAC	p.R792H	CACNA2D2_uc003dap.2_Missense_Mutation_p.R785H|CACNA2D2_uc003dao.2_5'Flank	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	792	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	ATCCAGGCTGCGGCGGTAGAA	0.612													6	39					0	0	0.004482	0	0
C3orf63	23272	broad.mit.edu	37	3	56667588	56667588	+	Silent	SNP	A	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr3:56667588A>G	uc003did.3	-	17	3149	c.3048T>C	c.(3046-3048)TTT>TTC	p.F1016F	C3orf63_uc003dib.3_Silent_p.F135F|C3orf63_uc003dic.3_Silent_p.F640F|C3orf63_uc003die.3_Silent_p.F1077F	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1077										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		AACCATCTACAAACTCCTGCA	0.408													21	106					0	0	0.012319	0	0
LRIG1	26018	broad.mit.edu	37	3	66455646	66455646	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr3:66455646G>A	uc003dmx.2	-	9	1150	c.1136C>T	c.(1135-1137)TCA>TTA	p.S379L	LRIG1_uc011bfu.1_5'Flank|LRIG1_uc003dmw.2_Missense_Mutation_p.S45L|LRIG1_uc010hnz.2_Missense_Mutation_p.S119L|LRIG1_uc010hoa.2_Missense_Mutation_p.S379L	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	379	Extracellular (Potential).					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GTCGAGCCCTGAGAAGGCGCC	0.627													6	42					0	0	0.001984	0	0
IMPG2	50939	broad.mit.edu	37	3	100963077	100963077	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr3:100963077G>A	uc003duq.1	-	13	2301	c.2098C>T	c.(2098-2100)CTA>TTA	p.L700L	IMPG2_uc011bhe.1_Silent_p.L563L	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	700	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGGAGGGTTAGAGACGCAGAT	0.473													10	123					0	0	0.006214	0	0
BOC	91653	broad.mit.edu	37	3	112993328	112993328	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr3:112993328G>A	uc003dzx.2	+	9	1962	c.1341G>A	c.(1339-1341)GCG>GCA	p.A447A	BOC_uc003dzy.2_Silent_p.A447A|BOC_uc003dzz.2_Silent_p.A447A|BOC_uc003eab.2_Silent_p.A148A	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	447	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GGCAACCGGCGCTCCCCAGAC	0.662													13	167					0	0	0.013537	0	0
DZIP1L	199221	broad.mit.edu	37	3	137800604	137800604	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr3:137800604G>A	uc003erq.2	-	9	1569	c.1206C>T	c.(1204-1206)ATC>ATT	p.I402I	DZIP1L_uc003err.1_Silent_p.I402I	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	402	Potential.					intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						ACAAGGACTGGATCTGCAAAG	0.502													44	62					0	0	0.013114	0	0
TRIM59	286827	broad.mit.edu	37	3	160156239	160156239	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr3:160156239C>G	uc003fdm.2	-	3	928	c.733G>C	c.(733-735)GAG>CAG	p.E245Q	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	245	Potential.					integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AGTGGAGACTCTTCTTGTAAA	0.353													15	294					0	0	0.004990	0	0
ATP13A4	84239	broad.mit.edu	37	3	193207650	193207650	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr3:193207650G>C	uc003ftd.2	-	7	715	c.607C>G	c.(607-609)CTA>GTA	p.L203V	ATP13A4_uc003fte.1_Missense_Mutation_p.L203V|ATP13A4_uc011bsr.1_5'UTR	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	203	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AATGGATTTAGAACCTGTTGG	0.338													5	147					0	0	0.001168	0	0
GABRA2	2555	broad.mit.edu	37	4	46252457	46252457	+	Missense_Mutation	SNP	C	A	A	rs145736784		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr4:46252457C>A	uc003gxc.3	-	9	1897	c.1224G>T	c.(1222-1224)AAG>AAT	p.K408N	GABRA2_uc010igc.2_Missense_Mutation_p.K408N|GABRA2_uc011bzc.1_Missense_Mutation_p.K413N	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	408	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.K408K(1)		ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGAAAGTTTTCTTTGCTTCAG	0.398													34	145					2.5098e-30	2.71553e-30	0.021022	1	0
EEF1A1P9	441032	broad.mit.edu	37	4	106406111	106406111	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr4:106406111C>T	uc003hxt.1	+	1	249	c.119C>T	c.(118-120)ACT>ATT	p.T40I		NR_003586				SubName: Full=Eukaryotic translation elongation factor 1 alpha; Flags: Fragment;												0						TACTATGTGACTATCATTGAT	0.438													19	53					0	0	0.010504	0	0
GPM6A	2823	broad.mit.edu	37	4	176561306	176561306	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr4:176561306C>T	uc003iuf.2	-	6	1462	c.658G>A	c.(658-660)GGA>AGA	p.G220R	GPM6A_uc011ckj.1_Missense_Mutation_p.G213R|GPM6A_uc003iug.2_Missense_Mutation_p.G220R|GPM6A_uc003iuh.2_Missense_Mutation_p.G209R	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	220	Helical; (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		GCCCCAGCTCCAGCAAGTGCC	0.433													11	72					0	0	0.008291	0	0
SDHA	6389	broad.mit.edu	37	5	236602	236602	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:236602G>A	uc003jao.3	+	10	1435	c.1320G>A	c.(1318-1320)GAG>GAA	p.E440E	SDHA_uc011clv.1_Silent_p.E440E|SDHA_uc011clw.1_Silent_p.E392E|SDHA_uc003jap.3_Silent_p.E440E|SDHA_uc003jaq.3_Silent_p.E215E|SDHA_uc003jar.3_Silent_p.E34E	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	440		FAD (By similarity).			nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CCTGTGGGGAGGCCGCCTGTG	0.592									Familial_Paragangliomas				15	105					0	0	0.003163	0	0
SLC9A3	6550	broad.mit.edu	37	5	480053	480053	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:480053G>A	uc003jbe.2	-	10	1657	c.1545C>T	c.(1543-1545)CTC>CTT	p.L515L	SLC9A3_uc011clx.1_Silent_p.L506L|uc011cly.1_RNA	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	515	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GGACCCTGCTGAGGAACTTCC	0.627													9	161					0	0	0.006214	0	0
SEMA5A	9037	broad.mit.edu	37	5	9197364	9197364	+	Silent	SNP	C	T	T	rs1806117		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:9197364C>T	uc003jek.2	-	10	1696	c.984G>A	c.(982-984)GCG>GCA	p.A328A		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	328	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						AGAAGGCCTGCGCGATGGCGC	0.612													18	170					0	0	0.006122	0	0
MARCH6	10299	broad.mit.edu	37	5	10377945	10377945	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:10377945G>A	uc003jet.1	+	2	238	c.55G>A	c.(55-57)GAG>AAG	p.E19K	MARCH6_uc011cmu.1_Missense_Mutation_p.E19K|MARCH6_uc003jeu.1_5'UTR|MARCH6_uc011cmv.1_Intron	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	19	Cytoplasmic (Potential).|RING-CH-type.				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						AGGAACACCTGAGAAACCGCT	0.338													21	96					0	0	0.014323	0	0
GPBP1	65056	broad.mit.edu	37	5	56557074	56557074	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:56557074G>C	uc003jrh.3	+	11	2502	c.1228G>C	c.(1228-1230)GAT>CAT	p.D410H	GPBP1_uc010iwg.2_Missense_Mutation_p.D430H|GPBP1_uc003jri.3_Missense_Mutation_p.D239H|GPBP1_uc003jrj.3_Missense_Mutation_p.D402H|GPBP1_uc003jrk.3_Missense_Mutation_p.D417H|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		CTTAACTGAGGATGAAATGAG	0.328													19	109					0	0	0.010504	0	0
PCDHA12	56137	broad.mit.edu	37	5	140257039	140257039	+	Missense_Mutation	SNP	C	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:140257039C>A	uc003lic.2	+	1	2109	c.1982C>A	c.(1981-1983)TCC>TAC	p.S661Y	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.S661Y	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	661	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCTGACGTCCACGGCCACG	0.692													14	64					4.3838e-07	4.54446e-07	0.016723	1	0
LARS	51520	broad.mit.edu	37	5	145531511	145531511	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:145531511C>T	uc003lnx.1	-	14	1577	c.1339G>A	c.(1339-1341)GAT>AAT	p.D447N	LARS_uc011dbq.1_Missense_Mutation_p.D401N|LARS_uc011dbr.1_Missense_Mutation_p.D393N|LARS_uc011dbs.1_Missense_Mutation_p.D420N	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	447	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TTCAACTCATCACAAATGGTT	0.398													23	164					0	0	0.014323	0	0
SPINK5	11005	broad.mit.edu	37	5	147503405	147503405	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:147503405C>T	uc003lox.2	+	27	2621	c.2548C>T	c.(2548-2550)CGT>TGT	p.R850C	SPINK5_uc010jgr.2_Missense_Mutation_p.R831C|SPINK5_uc003low.2_Missense_Mutation_p.R850C|SPINK5_uc003loy.2_Missense_Mutation_p.R850C	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	850	Kazal-like 13.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATCTGTGTCGTGAATTTCG	0.388													6	38					0	0	0.001168	0	0
PANK3	79646	broad.mit.edu	37	5	167995656	167995656	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:167995656G>A	uc003lzz.1	-	2	676	c.376C>T	c.(376-378)CGC>TGC	p.R126C		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	126					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		CCTACTGTGCGAAAATCTTTT	0.373													6	98					0	0	0.001168	0	0
GABRP	2568	broad.mit.edu	37	5	170236741	170236741	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr5:170236741G>C	uc003mau.2	+	9	1200	c.1002G>C	c.(1000-1002)CAG>CAC	p.Q334H	GABRP_uc011dev.1_Intron	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	334	Cytoplasmic (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCTTACAGCAGATGGCAGCCA	0.507											OREG0017032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	76					0	0	0.006320	0	0
JARID2	3720	broad.mit.edu	37	6	15496965	15496965	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:15496965G>A	uc003nbj.2	+	7	1753	c.1509G>A	c.(1507-1509)ACG>ACA	p.T503T	JARID2_uc011diu.1_Silent_p.T367T|JARID2_uc011div.1_Silent_p.T331T|JARID2_uc011diw.1_Silent_p.T465T	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	503					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGCGGGCCACGGCCGGGAAGA	0.642													6	49					0	0	0.001168	0	0
EGFL8	80864	broad.mit.edu	37	6	32135384	32135384	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:32135384C>T	uc003oab.1	+	8	844	c.786C>T	c.(784-786)ATC>ATT	p.I262I	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Silent_p.I262I	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	262						extracellular region|integral to membrane	calcium ion binding				0						GTGACCGGATCGAATCTCTCA	0.647													19	121					0	0	0.008871	0	0
PKHD1	5314	broad.mit.edu	37	6	51483976	51483976	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:51483976C>T	uc003pah.1	-	67	12404	c.12128G>A	c.(12127-12129)AGC>AAC	p.S4043N		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	4043	Cytoplasmic (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AAGCCCCAAGCTGCCACTTTG	0.547													29	50					0	0	0.005443	0	0
TINAG	27283	broad.mit.edu	37	6	54191661	54191661	+	Missense_Mutation	SNP	C	T	T	rs115438249	byFrequency	TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:54191661C>T	uc003pcj.2	+	4	717	c.571C>T	c.(571-573)CGC>TGC	p.R191C	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	191					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TTTTAAATTTCGCCTTGGCAC	0.373													11	81					0	0	0.016723	0	0
UBE2CBP	90025	broad.mit.edu	37	6	83732175	83732175	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:83732175G>C	uc003pjp.2	-	7	951	c.843C>G	c.(841-843)ATC>ATG	p.I281M	UBE2CBP_uc011dyx.1_Intron|UBE2CBP_uc003pjq.2_Missense_Mutation_p.I71M	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	281						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)		TTCTTACCAAGATATACACTT	0.413													4	28					0	0	0.009096	0	0
AIM1	202	broad.mit.edu	37	6	106967523	106967523	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:106967523G>C	uc003prh.2	+	2	1703	c.1216G>C	c.(1216-1218)GAG>CAG	p.E406Q		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	406							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TAAGCTCTTAGAGAAGGAGGA	0.458													17	88					0	0	0.004007	0	0
UTRN	7402	broad.mit.edu	37	6	144875962	144875962	+	Missense_Mutation	SNP	A	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:144875962A>G	uc003qkt.2	+	48	7159	c.7067A>G	c.(7066-7068)GAG>GGG	p.E2356G		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2356					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AGAAAATATGAGGCTCGACTC	0.438													6	54					0	0	0.001984	0	0
INTS1	26173	broad.mit.edu	37	7	1525079	1525079	+	Silent	SNP	G	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:1525079G>T	uc003skn.2	-	23	3104	c.3003C>A	c.(3001-3003)GGC>GGA	p.G1001G	INTS1_uc003skp.1_Silent_p.G348G	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1001					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CCCGCAGGCTGCCCTCCGAAA	0.667													9	45					3.09899e-07	3.22947e-07	0.004482	1	0
SDK1	221935	broad.mit.edu	37	7	3998591	3998591	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:3998591G>C	uc003smx.2	+	8	1318	c.1179G>C	c.(1177-1179)GAG>GAC	p.E393D		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	393	Ig-like C2-type 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CTGAGCCCGAGAGTCGGATTT	0.458													39	114					0	0	0.014410	0	0
ZNF680	340252	broad.mit.edu	37	7	63982011	63982011	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:63982011C>G	uc003tta.2	-	4	1294	c.1121G>C	c.(1120-1122)GGA>GCA	p.G374A	ZNF680_uc010kzr.2_Missense_Mutation_p.G301A	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				GGATTTCTCTCCAGTATGAAT	0.358													4	57					0	0	0.009096	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97949382	97949382	+	Silent	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:97949382C>G	uc003upj.2	-	5	599	c.336G>C	c.(334-336)GTG>GTC	p.V112V		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	112	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			TCATATATTTCACGTCAAGTT	0.433													7	106					0	0	0.003080	0	0
NRCAM	4897	broad.mit.edu	37	7	107848053	107848053	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:107848053C>T	uc003vfb.2	-	13	1597	c.1126G>A	c.(1126-1128)GAG>AAG	p.E376K	NRCAM_uc003vfc.2_Missense_Mutation_p.E370K|NRCAM_uc011kmk.1_Missense_Mutation_p.E371K|NRCAM_uc003vfd.2_Missense_Mutation_p.E352K|NRCAM_uc003vfe.2_Missense_Mutation_p.E352K	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	376	Ig-like 4.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						GTCCCATCCTCTCCTGGGGAC	0.443													10	59					0	0	0.008291	0	0
KCND2	3751	broad.mit.edu	37	7	120373014	120373014	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:120373014G>A	uc003vjj.1	+	2	2138	c.1173G>A	c.(1171-1173)TCG>TCA	p.S391S		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	391	Helical; Name=Segment S6; (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					CTATCTGTTCGCTGAGTGGGG	0.423													15	84					0	0	0.003163	0	0
REPIN1	29803	broad.mit.edu	37	7	150069696	150069696	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:150069696G>A	uc010lpq.1	+	4	1855	c.1366G>A	c.(1366-1368)GAT>AAT	p.D456N	REPIN1_uc003whd.2_Missense_Mutation_p.D445N|REPIN1_uc010lpr.1_Missense_Mutation_p.D513N|REPIN1_uc003whc.2_Missense_Mutation_p.D456N|REPIN1_uc003whe.2_Missense_Mutation_p.D456N	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	456					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CCACGCCCCCGATCGGCCCTT	0.731													5	34					0	0	0.001168	0	0
ATG9B	285973	broad.mit.edu	37	7	150720969	150720969	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:150720969C>T	uc011kvc.1	-	1	618	c.542G>A	c.(541-543)GGG>GAG	p.G181E	ATG9B_uc003wig.3_5'Flank	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	181	Cytoplasmic (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACCTCGGAGCCCTTCAGGGAC	0.612													5	20					0	0	0.014758	0	0
ACCN3	9311	broad.mit.edu	37	7	150745994	150745994	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:150745994G>A	uc003win.2	+	1	390	c.22G>A	c.(22-24)GAG>AAG	p.E8K	ACCN3_uc003wio.2_Missense_Mutation_p.E8K|ACCN3_uc003wip.2_Missense_Mutation_p.E8K|ACCN3_uc003wiq.2_RNA	NM_004769	NP_004760	Q9UHC3	ACCN3_HUMAN	amiloride-sensitive cation channel 3 isoform a	8	Cytoplasmic (Potential).				sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTCAGGCCCAGAGGAGGCCCG	0.662													4	92					0	0	0.009096	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926524	157926524	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:157926524G>A	uc003wno.2	-	9	1522	c.1401C>T	c.(1399-1401)GCC>GCT	p.A467A	PTPRN2_uc003wnp.2_Silent_p.A450A|PTPRN2_uc003wnq.2_Silent_p.A467A|PTPRN2_uc003wnr.2_Silent_p.A429A|PTPRN2_uc011kwa.1_Silent_p.A490A	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	467	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CAAACGCAGCGGCCCCGGGCT	0.632													12	82					0	0	0.020292	0	0
STC1	6781	broad.mit.edu	37	8	23709032	23709032	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr8:23709032C>T	uc003xdw.1	-	3	558	c.274G>A	c.(274-276)GTC>ATC	p.V92I		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor	92					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		CTCTCTTTGACGAATGCTTTT	0.507													7	39					0	0	0.001984	0	0
FUT10	84750	broad.mit.edu	37	8	33247035	33247035	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr8:33247035C>T	uc003xje.2	-	4	1014	c.658G>A	c.(658-660)GAC>AAC	p.D220N	FUT10_uc003xjc.2_Missense_Mutation_p.D227N|FUT10_uc003xjd.2_Missense_Mutation_p.D192N|FUT10_uc011lbi.1_Missense_Mutation_p.D270N|FUT10_uc003xjf.2_Missense_Mutation_p.D158N|FUT10_uc003xjg.2_Missense_Mutation_p.D192N|FUT10_uc003xjh.2_Missense_Mutation_p.D220N	NM_032664	NP_116053	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10	220	Lumenal (Potential).				embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			ovary(1)|pancreas(1)	2				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		GGGTCACAGTCTGACTGTACA	0.473													18	121					0	0	0.006122	0	0
TSPYL5	85453	broad.mit.edu	37	8	98289031	98289031	+	Missense_Mutation	SNP	G	A	A	rs144247525		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr8:98289031G>A	uc003yhy.2	-	1	1146	c.1042C>T	c.(1042-1044)CGT>TGT	p.R348C		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	348					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					AAGAAACTACGGTTGTTTTCT	0.498													22	147					0	0	0.012319	0	0
EIF3E	3646	broad.mit.edu	37	8	109252288	109252288	+	Missense_Mutation	SNP	T	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr8:109252288T>A	uc003ymu.2	-	3	250	c.222A>T	c.(220-222)AGA>AGT	p.R74S	EIF3E_uc003ymt.2_Missense_Mutation_p.R25S|EIF3E_uc003ymv.2_5'UTR|EIF3E_uc010mci.1_Missense_Mutation_p.R74S|EIF3E_uc010mcj.1_Missense_Mutation_p.R74S	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	74	Sufficient for interaction with TRIM27.|Sufficient for interaction with EPAS1.				negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			CCACTGTGGTTCTTTTCTCTC	0.373													19	119					0	0	0.006122	0	0
CPSF1	29894	broad.mit.edu	37	8	145620684	145620684	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr8:145620684G>A	uc003zcj.2	-	27	3137	c.3062C>T	c.(3061-3063)ACG>ATG	p.T1021M	MIR939_hsa-mir-939|MI0005761_5'Flank|CPSF1_uc011lld.1_RNA	NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	1021					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			ATAGTGGGCCGTGCAGCGCAG	0.662													12	52					0	0	0.010729	0	0
Unknown	0	broad.mit.edu	37	9	68414214	68414214	+	RNA	SNP	G	A	A	rs3887767		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr9:68414214G>A	uc004aex.2	+	1		c.769G>A								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		AGAGGAGGGAGGAGGGTGACA	0.413													2	4					0	0	0.004672	0	0
PRUNE2	158471	broad.mit.edu	37	9	79328481	79328481	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr9:79328481G>A	uc010mpk.2	-	7	1037	c.913C>T	c.(913-915)CAG>TAG	p.Q305*		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	305					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GGGCTCACCTGACTGCACAGC	0.532													7	20					0	0	0.003080	0	0
Unknown	0	broad.mit.edu	37	9	90747283	90747283	+	Silent	SNP	A	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr9:90747283A>G	uc011lti.1	-	4	698	c.669T>C	c.(667-669)TCT>TCC	p.S223S						SubName: Full=cDNA FLJ59639;																		GAGGAGGCGGAGAGCAGGCCA	0.602													33	223					0	0	0.015359	0	0
KIAA0368	23392	broad.mit.edu	37	9	114135509	114135509	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr9:114135509C>T	uc004bfe.1	-	42	4811	c.4811G>A	c.(4810-4812)CGG>CAG	p.R1604Q		NM_001080398	NP_001073867			KIAA0368 protein												0						GCTGCTATCCCGTGAGGTCTG	0.338													25	183					0	0	0.005443	0	0
PBX3	5090	broad.mit.edu	37	9	128728131	128728131	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr9:128728131G>A	uc004bqb.2	+	9	1350	c.1234G>A	c.(1234-1236)GCA>ACA	p.A412T	PBX3_uc004bqc.2_Missense_Mutation_p.A231T|PBX3_uc004bqd.2_3'UTR|PBX3_uc011lzw.1_Missense_Mutation_p.A337T|PBX3_uc011lzx.1_3'UTR|PBX3_uc004bqe.2_Missense_Mutation_p.A320T	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	412					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						CTGGCAGGACGCAACAACTCC	0.478													38	247					0	0	0.006230	0	0
SETX	23064	broad.mit.edu	37	9	135145014	135145014	+	Silent	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr9:135145014C>T	uc004cbk.2	-	25	7458	c.7275G>A	c.(7273-7275)TTG>TTA	p.L2425L	SETX_uc004cbj.2_Silent_p.L2044L|SETX_uc010mzt.2_Silent_p.L2011L	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2425					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCAGGGTCCTCAAATGTCCGA	0.408											OREG0019570	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	404					0	0	0.014323	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212129	26212129	+	Missense_Mutation	SNP	T	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:26212129T>C	uc004dbr.2	+	2	315	c.166T>C	c.(166-168)TCT>CCT	p.S56P	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	56	Ser-rich.									ovary(3)	3						TCGTAGGTCTTCTGATGCCTC	0.552													4	187					0	0	0.009096	0	0
DDX3X	1654	broad.mit.edu	37	X	41202541	41202541	+	Missense_Mutation	SNP	G	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:41202541G>T	uc004dfe.2	+	7	1471	c.616G>T	c.(616-618)GTG>TTG	p.V206L	DDX3X_uc010nhf.1_Missense_Mutation_p.V190L|DDX3X_uc004dff.2_Missense_Mutation_p.V206L|DDX3X_uc011mkq.1_Missense_Mutation_p.V190L|DDX3X_uc011mkr.1_Missense_Mutation_p.V206L|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	206	Q motif.|ATP.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						CCCAACTCCAGTGCAAAAGCA	0.373										HNSCC(61;0.18)			17	68					8.28177e-16	8.86373e-16	0.007413	1	0
USP11	8237	broad.mit.edu	37	X	47104314	47104314	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:47104314G>C	uc004dhp.2	+	15	2206	c.2206G>C	c.(2206-2208)GAA>CAA	p.E736Q	USP11_uc004dhq.2_Missense_Mutation_p.E462Q	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	736					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CTCCCCTGAAGAAGTCCATGG	0.607													12	123					0	0	0.016723	0	0
PORCN	64840	broad.mit.edu	37	X	48374529	48374529	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:48374529C>T	uc010nie.1	+	13	1326	c.1168C>T	c.(1168-1170)CGC>TGC	p.R390C	PORCN_uc004djr.1_Missense_Mutation_p.R385C|PORCN_uc004djs.1_Missense_Mutation_p.R379C|PORCN_uc004djt.1_Missense_Mutation_p.R308C|PORCN_uc011mlx.1_Missense_Mutation_p.R308C|PORCN_uc004dju.1_Missense_Mutation_p.R248C|PORCN_uc004djv.1_Missense_Mutation_p.R390C|PORCN_uc004djw.1_Missense_Mutation_p.R384C	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	390	Extracellular (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						GCACCAGCATCGCTTGGTGAG	0.572													11	68					0	0	0.010729	0	0
GPKOW	27238	broad.mit.edu	37	X	48976099	48976099	+	Missense_Mutation	SNP	C	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:48976099C>T	uc004dmr.2	-	4	532	c.525G>A	c.(523-525)ATG>ATA	p.M175I		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	175	G-patch.					nucleus	nucleic acid binding			ovary(2)	2						GTTTCCAGCCCATGCCCCGCA	0.602													6	42					0	0	0.001168	0	0
HUWE1	10075	broad.mit.edu	37	X	53561048	53561048	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:53561048G>A	uc004dsp.2	-	83	13344	c.12942C>T	c.(12940-12942)CTC>CTT	p.L4314L	HUWE1_uc004dsn.2_Silent_p.L3122L	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4314	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCATGCCTTCGAGGGCAGCAA	0.507													42	119					0	0	0.006999	0	0
HDAC8	55869	broad.mit.edu	37	X	71710840	71710840	+	Missense_Mutation	SNP	G	C	C			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:71710840G>C	uc004eau.2	-	6	609	c.567C>G	c.(565-567)TTC>TTG	p.F189L	HDAC8_uc011mqe.1_Missense_Mutation_p.F46L|HDAC8_uc011mqf.1_5'UTR|HDAC8_uc011mqg.1_Missense_Mutation_p.F98L|HDAC8_uc011mqh.1_Missense_Mutation_p.F98L|HDAC8_uc010nlk.1_Missense_Mutation_p.F60L|HDAC8_uc004eav.2_Missense_Mutation_p.F189L|HDAC8_uc004eaw.2_RNA	NM_018486	NP_060956	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	189	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding				0	Renal(35;0.156)				Vorinostat(DB02546)	AGGTGAAACTGAATGCGTCTT	0.388													6	76					0	0	0.001984	0	0
PGK1	5230	broad.mit.edu	37	X	77373593	77373593	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:77373593G>A	uc004ecz.3	+	6	739	c.567G>A	c.(565-567)TTG>TTA	p.L189L	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Silent_p.L161L	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	189					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						GTGGGTTTTTGATGAAGAAGG	0.478													19	235					0	0	0.006122	0	0
DOCK11	139818	broad.mit.edu	37	X	117742069	117742069	+	Missense_Mutation	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:117742069G>A	uc004eqp.2	+	25	2779	c.2716G>A	c.(2716-2718)GAA>AAA	p.E906K	DOCK11_uc004eqq.2_Missense_Mutation_p.E672K	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	906					blood coagulation	cytosol	GTP binding			ovary(3)	3						GTGCCATGAAGAAGGCTTGGA	0.323													11	134					0	0	0.008291	0	0
CUL4B	8450	broad.mit.edu	37	X	119669687	119669687	+	Missense_Mutation	SNP	C	G	G			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:119669687C>G	uc004esw.2	-	18	2649	c.2212G>C	c.(2212-2214)GAG>CAG	p.E738Q	CUL4B_uc010nqq.2_Missense_Mutation_p.E439Q|CUL4B_uc004esv.2_Missense_Mutation_p.E720Q	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	738					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						CCACTTACCTCTTTAAATTCT	0.343													17	268					0	0	0.008871	0	0
GAB3	139716	broad.mit.edu	37	X	153941667	153941667	+	Silent	SNP	G	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:153941667G>A	uc004fmj.1	-	3	456	c.408C>T	c.(406-408)TCC>TCT	p.S136S	GAB3_uc004fmk.1_Silent_p.S137S|GAB3_uc010nve.1_Silent_p.S137S|GAB3_uc004fml.1_5'UTR	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	136										ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCTGCAGGGAGGAGGGCGTGT	0.507													21	181					0	0	0.012319	0	0
MST1P2	11209	broad.mit.edu	37	1	16974141	16974141	+	RNA	DEL	G	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:16974141delG	uc009vow.2	+	5		c.951delG			CROCCL1_uc001azg.1_5'Flank|CROCCL1_uc001azi.1_5'Flank|MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_Intron|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_Intron|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_Intron|MST1P2_uc001azm.3_Intron					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						TGGCTTGGCCGGGGAGGTCAG	0.667													4	8	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	25371441	25371442	+	IGR	DEL	AG	-	-	rs61298913		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:25371441_25371442delAG								RUNX3 (79829 upstream) : SYF2 (177325 downstream)																							gaaggaaggaagaaggaaggaa	0.050													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	48209051	48209052	+	IGR	INS	-	TGGTGA	TGGTGA	rs142247408	by1000genomes	TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:48209051_48209052insTGGTGA								FOXD2 (302689 upstream) : SKINTL (358335 downstream)																							ggtagtggtggtggtggtggtg	0.000													3	3	---	---	---	---					
ALG6	29929	broad.mit.edu	37	1	63894433	63894434	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:63894433_63894434insT	uc010oow.1	+	13	1393_1394	c.1088_1089insT	c.(1087-1089)CCTfs	p.P363fs	ALG6_uc001daz.2_RNA|ALG6_uc009waj.2_RNA|ALG6_uc010oox.1_Frame_Shift_Ins_p.P110fs	NM_013339	NP_037471	Q9Y672	ALG6_HUMAN	dolichyl pyrophosphate Man9GlcNAc2	363	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity				0						AGTGAAATTCCTTTTATGTCTA	0.228													8	89	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	96914049	96914049	+	IGR	DEL	C	-	-	rs1931180	by1000genomes	TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:96914049delC								None (None upstream) : PTBP2 (273126 downstream)																							CTTTGGTTTTCTTTTTCGCAT	0.313													3	5	---	---	---	---					
HIST3H2A	92815	broad.mit.edu	37	1	228646357	228646358	+	5'Flank	DEL	GT	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr1:228646357_228646358delGT	uc001hsy.2	-							NM_033445	NP_254280	Q7L7L0	H2A3_HUMAN	histone cluster 3, H2a						nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1		Prostate(94;0.183)				AATCTGAGCCgtgtgtgtgtgt	0.475													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	8203152	8203152	+	IGR	DEL	A	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr10:8203152delA								GATA3 (85990 upstream) : None (None downstream)																							ttatttatttatttatttTTT	0.353													3	3	---	---	---	---					
DUSP8	1850	broad.mit.edu	37	11	1577819	1577820	+	Frame_Shift_Del	DEL	CG	-	-	rs61747093		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:1577819_1577820delCG	uc001lts.2	-	7	1934_1935	c.1806_1807delCG	c.(1804-1809)CGCGGCfs	p.R602fs		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	602_603					inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		AGCTCCTCGCCGCGCGCGCGCC	0.752													2	4	---	---	---	---					
FAM99B	100132464	broad.mit.edu	37	11	1707878	1707881	+	5'Flank	DEL	CTCA	-	-	rs78379018		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:1707878_1707881delCTCA	uc010qxa.1	-						uc001ltz.1_5'Flank	NR_026642				Homo sapiens family with sequence similarity 99, member B (FAM99B), non-coding RNA.												0						tcttccctccctcacttccttcct	0.216													3	3	---	---	---	---					
NAT10	55226	broad.mit.edu	37	11	34153676	34153677	+	Frame_Shift_Del	DEL	TA	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr11:34153676_34153677delTA	uc001mvk.2	+	15	1769_1770	c.1525_1526delTA	c.(1525-1527)TATfs	p.Y509fs	NAT10_uc010ren.1_Frame_Shift_Del_p.Y437fs	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	509						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				ACCCAGGTACTATGTTAATAGA	0.455													9	596	---	---	---	---					
Unknown	0	broad.mit.edu	37	14	98480465	98480470	+	IGR	DEL	TCTTTC	-	-	rs72290183		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr14:98480465_98480470delTCTTTC								C14orf64 (36004 upstream) : C14orf177 (697480 downstream)																							ttccttcctttctttctctttctttc	0.000													3	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	14	101528241	101528242	+	5'Flank	DEL	AG	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr14:101528241_101528242delAG	uc010awh.1	+						MIR377_hsa-mir-377|MI0000785_5'Flank|MIR541_hsa-mir-541|MI0005539_5'Flank					DM004799																		TCTCGGAGGTAgagagagagag	0.470													8	44	---	---	---	---					
ADAMTSL3	57188	broad.mit.edu	37	15	84488580	84488582	+	In_Frame_Del	DEL	AGA	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr15:84488580_84488582delAGA	uc002bjz.3	+	6	605_607	c.381_383delAGA	c.(379-384)GCAGAA>GCA	p.E128del	ADAMTSL3_uc002bjy.1_In_Frame_Del_p.E128del|ADAMTSL3_uc010bmt.1_In_Frame_Del_p.E128del|ADAMTSL3_uc010bmu.1_In_Frame_Del_p.E128del	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	128						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTCCAGATGCAGAAGATTTCAGA	0.507													10	100	---	---	---	---					
MIR1285-2	100302268	broad.mit.edu	37	2	70481272	70481272	+	5'Flank	DEL	T	-	-	rs112545635		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:70481272delT	hsa-mir-1285-2|MI0006347	-																							0						TATAGACCCAttttttttttt	0.189													2	4	---	---	---	---					
COL3A1	1281	broad.mit.edu	37	2	189873889	189873890	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr2:189873889_189873890insA	uc002uqj.1	+	48	3882_3883	c.3765_3766insA	c.(3763-3768)CGTAAAfs	p.R1255fs		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1255_1256	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	ATGGTTCTCGTAAAAACCCCGC	0.401													12	91	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	72742023	72742039	+	IGR	DEL	TTCCTTCCTTGCCTTCG	-	-	rs77638707		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr4:72742023_72742039delTTCCTTCCTTGCCTTCG								GC (72265 upstream) : NPFFR2 (155482 downstream)																							cttccttgttttccttccttgccttcgttccttcctt	0.000													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	6	15710434	15710437	+	IGR	DEL	CTTT	-	-	rs12191708		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:15710434_15710437delCTTT								DTNBP1 (47163 upstream) : MYLIP (418880 downstream)																							tccttccttcctttcttcctttct	0.088													3	4	---	---	---	---					
HCG22	285834	broad.mit.edu	37	6	31023076	31023078	+	RNA	DEL	GAG	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:31023076_31023078delGAG	uc010jsi.1	+	1		c.1093_1095delGAG			HCG22_uc003nsj.1_Intron	NR_003948				Homo sapiens HLA complex group 22 (HCG22), non-coding RNA.												0						aaaaaaaaaaGAGAGAGAGAGAG	0.177													2	4	---	---	---	---					
GRM4	2914	broad.mit.edu	37	6	34059739	34059747	+	In_Frame_Del	DEL	GTTCCACTT	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:34059739_34059747delGTTCCACTT	uc003oir.3	-	2	819_827	c.649_657delAAGTGGAAC	c.(649-657)AAGTGGAACdel	p.KWN217del	GRM4_uc011dsn.1_In_Frame_Del_p.KWN217del|GRM4_uc010jvh.2_In_Frame_Del_p.KWN217del|GRM4_uc010jvi.2_Intron|GRM4_uc010jvk.1_In_Frame_Del_p.KWN136del|GRM4_uc011dsl.1_In_Frame_Del_p.KWN77del|GRM4_uc003oiq.2_In_Frame_Del_p.KWN84del|GRM4_uc011dsm.1_In_Frame_Del_p.KWN48del	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	217_219	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	TGGACACATAGTTCCACTTGAGGGCACGG	0.627													7	85	---	---	---	---					
C6orf153	88745	broad.mit.edu	37	6	42989414	42989419	+	In_Frame_Del	DEL	GCCGGG	-	-	rs3833662		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr6:42989414_42989419delGCCGGG	uc003otp.1	+	1	30_35	c.22_27delGCCGGG	c.(22-27)GCCGGGdel	p.AG14del		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	14_15					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TAACTAccgcgccggggccggggccg	0.529													5	3	---	---	---	---					
INTS1	26173	broad.mit.edu	37	7	1546840	1546840	+	5'Flank	DEL	T	-	-	rs111819550		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:1546840delT	uc003skn.2	-						INTS1_uc003skq.2_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1						snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GTCAttattcttttttttttt	0.269													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	7	88269890	88269891	+	IGR	INS	-	T	T	rs113056340		TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:88269890_88269891insT								STEAP4 (333681 upstream) : ZNF804B (118862 downstream)																							AGAAGGAGCACTTTTTTTTTTT	0.248													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	7	101967963	101967964	+	IGR	INS	-	A	A	rs138796949	by1000genomes	TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr7:101967963_101967964insA								SH2B2 (5786 upstream) : SPDYE6 (18229 downstream)																							TTTTTTCCCTTAAAAAAAAAAG	0.371													3	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	8	67393251	67393255	+	IGR	DEL	AAAAA	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chr8:67393251_67393255delAAAAA								ADHFE1 (12209 upstream) : C8orf46 (12236 downstream)																							actctgtctcaaaaaaaaaaaaaaa	0.146													3	4	---	---	---	---					
SMC1A	8243	broad.mit.edu	37	X	53439197	53439199	+	In_Frame_Del	DEL	CTT	-	-			TCGA-BI-A0VR-01A-11D-A10S-08	TCGA-BI-A0VR-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc62866c-0dc0-4ef5-bc63-fee1e943a99f	e717369f-73df-46ca-a7f2-749b84b96616	g.chrX:53439197_53439199delCTT	uc004dsg.2	-	6	928_930	c.859_861delAAG	c.(859-861)AAGdel	p.K287del	SMC1A_uc011moe.1_In_Frame_Del_p.K265del|SMC1A_uc011mof.1_Intron	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	287	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						ATTCTGAGTCCTTCTCCCTTTTG	0.527													24	75	---	---	---	---					
