Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DNAJB12	54788	broad.mit.edu	37	10	74095536	74095536	+	Splice_Site	SNP	A	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr10:74095536A>T	uc001jsz.2	-	8	1410	c.1260_splice	c.e8+1		DNAJB12_uc001jta.2_3'UTR|DNAJB12_uc010qjv.1_Intron	NM_017626	NP_060096	Q9NXW2	DJB12_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 12 (DNAJB12), transcript variant 2, mRNA.						protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|large_intestine(2)|skin(1)	4						CCTGGCTCATACTTGGACCTC	0.627000														29			20		0	0	0.055883	0	0
KIFC3	3801	broad.mit.edu	37	16	57806198	57806198	+	Silent	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr16:57806198T>C	uc002emq.3	-	3	515	c.318A>G	c.(316-318)gtA>gtG	p.V106V	KIFC3_uc010vhw.2_Silent_p.V4V|KIFC3_uc002emn.3_Non-coding_Transcript|KIFC3_uc002emm.3_5'UTR|KIFC3_uc010vhx.2_5'UTR|KIFC3_uc010cdf.3_5'UTR|KIFC3_uc002emo.4_5'UTR|KIFC3_uc010vhy.2_Silent_p.V48V|KIFC3_uc002emp.3_Silent_p.V106V|KIFC3_uc010vhz.2_Silent_p.V128V|KIFC3_uc002emr.1_Intron|KIFC3_uc010cdg.1_Non-coding_Transcript	NM_001130100	NP_001123571	Q9BVG8	KIFC3_HUMAN	Homo sapiens kinesin family member C3 (KIFC3), transcript variant 2, mRNA.	106					epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(3)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(199;0.224)				TCAGGTGTTCTACCTGTGGGC	0.617000														39			29		0	0	0.125774	0	0
DUSP6	1848	broad.mit.edu	37	12	89744677	89744677	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr12:89744677A>G	uc001tay.3	-	1	1006	c.526T>C	c.(526-528)Tct>Cct	p.S176P	DUSP6_uc001taz.3_Intron	NM_001946	NP_001937	Q16828	DUS6_HUMAN	Homo sapiens dual specificity phosphatase 6 (DUSP6), transcript variant 1, mRNA.	176					MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(5)|lung(8)|skin(2)|urinary_tract(1)	16						TCCGAGGAAGAGTCAGAGCTG	0.607000														35			25		0	0	0.091800	0	0
GON4L	54856	broad.mit.edu	37	1	155638446	155638446	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr1:155638446A>T	uc010pgi.2	-	7	1457	c.1265T>A	c.(1264-1266)aTg>aAg	p.M422K	GON4L_uc021paz.1_Missense_Mutation_p.M264K|GON4L_uc010pgg.2_Missense_Mutation_p.M169K|GON4L_uc010pgh.2_Missense_Mutation_p.M273K|GON4L_uc009wqt.3_Missense_Mutation_p.M253K|GON4L_uc001flh.3_Missense_Mutation_p.M402K|GON4L_uc001fll.3_Missense_Mutation_p.M284K|GON4L_uc001flk.3_Missense_Mutation_p.M273K|GON4L_uc001flm.3_Missense_Mutation_p.M273K|GON4L_uc009wqu.3_Missense_Mutation_p.M117K|GON4L_uc009wqv.3_Missense_Mutation_p.M1K|GON4L_uc009wqw.3_Missense_Mutation_p.M253K|GON4L_uc001flj.3_Missense_Mutation_p.M264K|GON4L_uc001fli.3_Missense_Mutation_p.M284K|GON4L_uc001flo.3_Missense_Mutation_p.M218K|GON4L_uc001fln.3_Missense_Mutation_p.M330K|GON4L_uc010pgj.2_Missense_Mutation_p.M350K|GON4L_uc001flp.3_Missense_Mutation_p.M284K|GON4L_uc009wqx.3_Missense_Mutation_p.M422K|GON4L_uc010pgk.2_3'UTR	NM_001198903	NP_001185832	Q3T8J9	GON4L_HUMAN	Homo sapiens YY1 associated protein 1 (YY1AP1), transcript variant 10, mRNA.	873					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGCTCTGTTCATGTTGAGGTT	0.433000														77			39		0	0	0.111260	0	0
MYO1C	4641	broad.mit.edu	37	17	1370772	1370772	+	Splice_Site	SNP	A	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr17:1370772A>C	uc002fsp.3	-	30	3285	c.3065_splice	c.e30+1	p.S1022_splice	MYO1C_uc002fsn.3_Splice_Site_p.S1003_splice|MYO1C_uc002fso.3_Splice_Site_p.S987_splice	NM_001080779	NP_203693	O00159	MYO1C_HUMAN	Homo sapiens myosin IC (MYO1C), transcript variant 1, mRNA.	1022					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	ATP binding|actin binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCCGCGCCTCACCTGCCCTGG	0.677000														40			28		0	0	0.050027	0	0
MET	4233	broad.mit.edu	37	7	116423433	116423433	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr7:116423433T>A	uc003vij.3	+	18	3895	c.3708T>A	c.(3706-3708)agT>agA	p.S1236R	MET_uc010lkh.3_Missense_Mutation_p.S1254R|MET_uc011knj.2_Missense_Mutation_p.S806R	NM_000245	NP_000236	P08581	MET_HUMAN	Homo sapiens met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, mRNA.	1236	Interaction with RANBP9.|Protein kinase.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AATACTATAGTGTACACAACA	0.383000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)					37			52		0	0	0.139131	0	0
SLC2A8	29988	broad.mit.edu	37	9	130167105	130167105	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:130167105A>G	uc004bqu.3	+	7	1030	c.985A>G	c.(985-987)Atg>Gtg	p.M329V	SLC2A8_uc010mxj.3_Missense_Mutation_p.M329V	NM_014580	NP_055395	Q9NY64	GTR8_HUMAN	Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 8 (SLC2A8), mRNA.	329						cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	11						AGGTGTGGTCATGGTGTTCAG	0.697000														40			11		0	0	0.105934	0	0
ITGA6	3655	broad.mit.edu	37	2	173352903	173352903	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr2:173352903C>A	uc002uhp.1	+	18	2655	c.2452C>A	c.(2452-2454)Caa>Aaa	p.Q818K	ITGA6_uc010zdy.1_Missense_Mutation_p.Q699K|ITGA6_uc002uho.1_Missense_Mutation_p.Q818K|ITGA6_uc010fqm.1_Missense_Mutation_p.Q464K	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	Homo sapiens integrin, alpha 6 (ITGA6), transcript variant 1, mRNA.	857					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TGTTGGCGAGCAAGCTATGAA	0.368000														57			34		4.92203e-23	6.9861e-23	0.086207	1	0
GPR97	222487	broad.mit.edu	37	16	57719830	57719830	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr16:57719830C>T	uc002emh.3	+	10	1635	c.1532C>T	c.(1531-1533)tCc>tTc	p.S511F	GPR97_uc010vhv.2_Missense_Mutation_p.S391F|GPR97_uc010cdd.3_Non-coding_Transcript|GPR97_uc010cde.3_Missense_Mutation_p.S119F	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	Homo sapiens G protein-coupled receptor 97 (GPR97), mRNA.	511					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CTTTTCAACTCCTTGCAAGGT	0.597000														52			44		0	0	0.139131	0	0
FAT4	79633	broad.mit.edu	37	4	126411930	126411930	+	Silent	SNP	C	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr4:126411930C>A	uc003ifj.4	+	16	13953	c.13953C>A	c.(13951-13953)atC>atA	p.I4651I	FAT4_uc011cgp.2_Silent_p.I2892I|FAT4_uc003ifi.1_Silent_p.I2128I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	Homo sapiens FAT tumor suppressor homolog 4 (Drosophila) (FAT4), mRNA.	4651					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AATTTTCAATCCAGAGGCACA	0.502000														39			28		1.16021e-09	1.57074e-09	0.125774	1	0
APOB	338	broad.mit.edu	37	2	21251317	21251317	+	Nonsense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr2:21251317G>A	uc002red.3	-	12	1839	c.1711C>T	c.(1711-1713)Cag>Tag	p.Q571*		NM_000384	NP_000375	P04114	APOB_HUMAN	Homo sapiens apolipoprotein B (including Ag(x) antigen) (APOB), mRNA.	571	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATATCTGCCTGTGAAGGACTC	0.438000														69			47		0	0	0.139131	0	0
DST	667	broad.mit.edu	37	6	56463337	56463337	+	Silent	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr6:56463337T>C	uc003pcy.4	-	26	4104	c.3996A>G	c.(3994-3996)gcA>gcG	p.A1332A	DST_uc010kaa.1_Non-coding_Transcript	NM_015548	NP_056363	Q03001	DYST_HUMAN	Homo sapiens dystonin (DST), transcript variant 1eA, mRNA.	3744					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	Z disc|actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein C-terminus binding|protein binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TAGACTGTTCTGCTTTTAAAT	0.353000														20			12		0	0	0.080935	0	0
PPIB	5479	broad.mit.edu	37	15	64454355	64454355	+	Splice_Site	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr15:64454355T>C	uc002and.3	-	2	305	c.136_splice	c.e2-1	p.V46_splice	PPIB_uc010bgx.1_Splice_Site_p.V38_splice	NM_000942	NP_000933	P23284	PPIB_HUMAN	Homo sapiens peptidylprolyl isomerase B (cyclophilin B) (PPIB), mRNA.	46					protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			kidney(2)|large_intestine(2)|lung(6)	10					L-Proline(DB00172)	AAAATACACCTGAGGAAAGAG	0.463000														95			73		0	0	0.139131	0	0
TBCB	1155	broad.mit.edu	37	19	36606528	36606528	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr19:36606528C>G	uc002odg.1	+	0	641	c.66C>G	c.(64-66)ttC>ttG	p.F22L	POLR2I_uc002ode.3_5'Flank|POLR2I_uc002odf.3_5'Flank	NM_001281	NP_001272	Q99426	TBCB_HUMAN	Homo sapiens tubulin folding cofactor B (TBCB), mRNA.	22					'de novo' posttranslational protein folding|cell differentiation|nervous system development	cytoplasm|microtubule	protein binding			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCAACACCTTCCGCTCCGAGA	0.667000														14			9		0	0	0.047766	0	0
CPM	1368	broad.mit.edu	37	12	69326479	69326479	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr12:69326479T>A	uc001sup.3	-	1	200	c.139A>T	c.(139-141)Agt>Tgt	p.S47C	CPM_uc001sur.3_Missense_Mutation_p.S47C|CPM_uc001suq.3_Missense_Mutation_p.S47C	NM_198320	NP_938079	P14384	CBPM_HUMAN	Homo sapiens carboxypeptidase M (CPM), transcript variant 2, mRNA.	47					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TTCCCAATACTGTGTAAGTGA	0.473000														43			50		0	0	0.139131	0	0
ZNF644	84146	broad.mit.edu	37	1	91406116	91406116	+	Silent	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr1:91406116G>A	uc001dnw.3	-	2	1078	c.795C>T	c.(793-795)ttC>ttT	p.F265F	ZNF644_uc001dnv.3_Intron|ZNF644_uc001dnx.3_Intron|ZNF644_uc001dny.2_Silent_p.F265F	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	Homo sapiens zinc finger protein 644 (ZNF644), transcript variant 1, mRNA.	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		GAAATTGAATGAACTCTTTTT	0.353000														74			49		0	0	0.139131	0	0
RNF26	79102	broad.mit.edu	37	11	119206410	119206410	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:119206410G>A	uc001pwh.3	+	0	1201	c.578G>A	c.(577-579)aGc>aAc	p.S193N		NM_032015	NP_114404	Q9BY78	RNF26_HUMAN	Homo sapiens ring finger protein 26 (RNF26), mRNA.	193	Leu-rich.						zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)		CACATTTCCAGCAGTGCTGTG	0.622000														35			25		0	0	0.091800	0	0
MACF1	23499	broad.mit.edu	37	1	39800224	39800224	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr1:39800224T>G	uc021olw.1	+	0	3284	c.3284T>G	c.(3283-3285)aTt>aGt	p.I1095S	MACF1_uc021ols.1_Intron|MACF1_uc001cdc.2_Intron|MACF1_uc021olt.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdb.1_Intron	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	Homo sapiens microtubule-actin crosslinking factor 1 (MACF1), transcript variant 1, mRNA.	2660					Golgi to plasma membrane protein transport|Wnt receptor signaling pathway|cell cycle arrest|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|wound healing	Golgi apparatus|microtubule|ruffle membrane	ATPase activity|actin filament binding|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTCTCAGACATTAAAGATGGG	0.408000														37			18		0	0	0.043863	0	0
CIC	23152	broad.mit.edu	37	19	42795453	42795453	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr19:42795453G>A	uc002otf.1	+	9	2573	c.2533G>A	c.(2533-2535)Gcc>Acc	p.A845T		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	Homo sapiens capicua homolog (Drosophila) (CIC), mRNA.	845	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CCCAGCACCAGCCCCTGGGAC	0.677000			"""Mis, F, S"""		oligodendroglioma									21			17		0	0	0.038395	0	0
NEK10	152110	broad.mit.edu	37	3	27297799	27297799	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:27297799A>T	uc003cdt.2	-	23	2352	c.2078T>A	c.(2077-2079)aTc>aAc	p.I693N	NEK10_uc003cds.1_Missense_Mutation_p.I90N	NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	Homo sapiens NIMA (never in mitosis gene a)- related kinase 10 (NEK10), mRNA.	693	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AGAATACAGGATTGTTCCAAC	0.343000														15			6		0	0	0.038147	0	0
PTPRJ	5795	broad.mit.edu	37	11	48181586	48181586	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:48181586T>A	uc001ngp.4	+	21	3898	c.3543T>A	c.(3541-3543)gaT>gaA	p.D1181E		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, J (PTPRJ), transcript variant 1, mRNA.	1181	Tyrosine-protein phosphatase.				contact inhibition|negative regulation of MAP kinase activity|negative regulation of T cell receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						CCATCAGAGATTTCACAGTGA	0.393000														72			46		0	0	0.139131	0	0
ABCD4	5826	broad.mit.edu	37	14	74756774	74756774	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr14:74756774G>T	uc001xpr.2	-	12	1527	c.1375C>A	c.(1375-1377)Ctg>Atg	p.L459M	ABCD4_uc001xps.2_Missense_Mutation_p.L300M|ABCD4_uc010tur.2_Missense_Mutation_p.L355M	NM_005050	NP_005041	O14678	ABCD4_HUMAN	Homo sapiens ATP-binding cassette, sub-family D (ALD), member 4 (ABCD4), transcript variant 1, mRNA.	459	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			cervix(2)|endometrium(3)|kidney(3)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00153)		TTTTGTGGCAGGAATAGCACC	0.592000											OREG0022800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		45			26		1.80694e-10	2.48455e-10	0.144211	1	0
FCHO2	115548	broad.mit.edu	37	5	72378596	72378596	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr5:72378596A>C	uc003kcl.3	+	23	2305	c.2189A>C	c.(2188-2190)gAa>gCa	p.E730A	FCHO2_uc011csl.2_Missense_Mutation_p.E697A|FCHO2_uc010izb.3_Missense_Mutation_p.E158A|FCHO2_uc011csn.2_Missense_Mutation_p.E158A	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	Homo sapiens FCH domain only 2 (FCHO2), transcript variant 1, mRNA.	730										cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	17		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		AGGAATGCAGAACAAATGAAA	0.308000														4			7		0	0	0.038147	0	0
KIF13A	63971	broad.mit.edu	37	6	17796913	17796913	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr6:17796913T>G	uc003ncg.4	-	22	3089	c.2929A>C	c.(2929-2931)Aca>Cca	p.T977P	KIF13A_uc003ncf.3_Missense_Mutation_p.T977P|KIF13A_uc003nch.4_Missense_Mutation_p.T977P|KIF13A_uc003nci.4_Missense_Mutation_p.T977P	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	Homo sapiens kinesin family member 13A (KIF13A), transcript variant 1, mRNA.	977					Golgi to plasma membrane protein transport|cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TCATGCAGTGTTCTTGTCTTA	0.507000														77			62		0	0	0.139131	0	0
HERC5	51191	broad.mit.edu	37	4	89410409	89410409	+	Silent	SNP	C	G	G	rs141289100	byFrequency	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr4:89410409C>G	uc003hrt.3	+	15	2208	c.2055C>G	c.(2053-2055)gtC>gtG	p.V685V	HERC5_uc011cdm.2_Silent_p.V323V	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	Homo sapiens hect domain and RLD 5 (HERC5), mRNA.	685					ISG15-protein conjugation|innate immune response|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			NS(2)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|liver(2)|lung(17)|ovary(4)|prostate(1)|skin(4)	53		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		ATCTAACAGTCAGAAGGAATC	0.383000														107			87		0	0	0.139131	0	0
TYW1	55253	broad.mit.edu	37	7	66514966	66514966	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr7:66514966G>T	uc003tvn.3	+	7	1164	c.1015G>T	c.(1015-1017)Ggt>Tgt	p.G339C	TYW1_uc010lai.3_Non-coding_Transcript	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	Homo sapiens tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) (TYW1), mRNA.	339					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				AGAGAAGTCTGGTTTGTTCAG	0.383000														44			16		5.01169e-05	6.68226e-05	0.033300	1	0
FAT3	120114	broad.mit.edu	37	11	92616488	92616488	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:92616488T>C	uc001pdj.4	+	22	12883	c.12866T>C	c.(12865-12867)cTc>cCc	p.L4289P	FAT3_uc001pdi.4_Missense_Mutation_p.L729P	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	Homo sapiens FAT tumor suppressor homolog 3 (Drosophila) (FAT3), mRNA.	4289					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.L4289P(2)|p.L864P(1)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCCCCCAACCTCCCCGCCGTG	0.652000										TCGA Ovarian(4;0.039)				42			11		0	0	0.069288	0	0
LUC7L3	51747	broad.mit.edu	37	17	48818486	48818486	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr17:48818486T>C	uc002isq.3	+	3	398	c.230T>C	c.(229-231)aTg>aCg	p.M77T	LUC7L3_uc002isp.2_Non-coding_Transcript|LUC7L3_uc010wmw.2_Missense_Mutation_p.M1T|LUC7L3_uc002isr.3_Missense_Mutation_p.M77T|LUC7L3_uc002iss.3_Missense_Mutation_p.M77T	NM_016424	NP_057508	O95232	LC7L3_HUMAN	Homo sapiens LUC7-like 3 (S. cerevisiae) (LUC7L3), transcript variant 1, mRNA.	77					RNA splicing|apoptosis|mRNA processing|response to stress	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	12						TCTCGTTTCATGAAAGTTGGC	0.383000														180			66		0	0	0.139131	0	0
NEK10	152110	broad.mit.edu	37	3	27297798	27297798	+	Silent	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:27297798G>A	uc003cdt.2	-	23	2353	c.2079C>T	c.(2077-2079)atC>atT	p.I693I	NEK10_uc003cds.1_Silent_p.I90I	NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	Homo sapiens NIMA (never in mitosis gene a)- related kinase 10 (NEK10), mRNA.	693	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AAGAATACAGGATTGTTCCAA	0.343000														15			7		0	0	0.047766	0	0
TAS1R2	80834	broad.mit.edu	37	1	19181066	19181066	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr1:19181066C>T	uc001bba.1	-	2	899	c.898G>A	c.(898-900)Gcc>Acc	p.A300T		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	Homo sapiens taste receptor, type 1, member 2 (TAS1R2), mRNA.	300					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GACTCGGAGGCGATCCACACG	0.647000														33			19		0	0	0.049695	0	0
MYH14	79784	broad.mit.edu	37	19	50783389	50783389	+	Silent	SNP	C	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr19:50783389C>T	uc010enu.1	+	30	4175	c.4128C>T	c.(4126-4128)caC>caT	p.H1376H	MYH14_uc002prq.1_Silent_p.H1343H|MYH14_uc002prr.1_Silent_p.H1335H|MYH14_uc010ycb.2_Intron	NM_001145809	NP_001139281	Q7Z406	MYH14_HUMAN	Homo sapiens myosin, heavy chain 14, non-muscle (MYH14), transcript variant 3, mRNA.	1335					axon guidance|regulation of cell shape	myosin complex	ATP binding|actin binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CCCAGCTGCACGATGCCCAGG	0.607000														5			3		0	0	0.115264	0	0
NSUN2	54888	broad.mit.edu	37	5	6620336	6620336	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr5:6620336C>T	uc003jdu.3	-	6	1079	c.698G>A	c.(697-699)aGc>aAc	p.S233N	NSUN2_uc003jdt.3_5'UTR|NSUN2_uc011cmk.2_Missense_Mutation_p.S198N|NSUN2_uc003jdv.3_5'UTR	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	Homo sapiens NOP2/Sun domain family, member 2 (NSUN2), transcript variant 1, mRNA.	233						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						GATGCAGGGGCTGCTCAGCCT	0.502000														126			9		0	0	0.047766	0	0
RIPK4	54101	broad.mit.edu	37	21	43166867	43166867	+	Silent	SNP	G	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr21:43166867G>C	uc002yzn.1	-	4	786	c.738C>G	c.(736-738)ccC>ccG	p.P246P		NM_020639	NP_065690	Q96T11	Q96T11_HUMAN	Homo sapiens receptor-interacting serine-threonine kinase 4 (RIPK4), mRNA.	246						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CTCTGCACACGGGCGGCAGCT	0.657000														115			4		0	0	0.009096	0	0
VPS28	51160	broad.mit.edu	37	8	145651588	145651588	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr8:145651588G>T	uc003zct.1	-	2	131	c.41C>A	c.(40-42)cCt>cAt	p.P14H	VPS28_uc003zcs.1_Missense_Mutation_p.P14H	NM_183057	NP_898880	Q9UK41	VPS28_HUMAN	Homo sapiens vacuolar protein sorting 28 homolog (S. cerevisiae) (VPS28), transcript variant 2, mRNA.	14	VPS28 N-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTTGTTCCCAGGGGCTGCAAG	0.632000														4			6		0.00307968	0.00398547	0.038147	1	0
CLTC	1213	broad.mit.edu	37	17	57724783	57724783	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr17:57724783A>T	uc002ixr.1	+	2	730	c.287A>T	c.(286-288)aAc>aTc	p.N96I	CLTC_uc002ixp.3_Missense_Mutation_p.N92I|CLTC_uc002ixq.1_Missense_Mutation_p.N92I	NM_004859	NP_004850	Q00610	CLH1_HUMAN	Homo sapiens clathrin, heavy chain (Hc) (CLTC), mRNA.	92	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CAGATTTTTAACATTGAAATG	0.318000			T	"""ALK, TFE3"""	"""ALCL, renal """									59			26		0	0	0.091800	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110420393	110420393	+	Silent	SNP	G	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr8:110420393G>C	uc003yne.3	+	17	2033	c.1929G>C	c.(1927-1929)ggG>ggC	p.G643G		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	Homo sapiens polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 (PKHD1L1), mRNA.	643					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTGGGATGGGATCGCTTCTA	0.428000										HNSCC(38;0.096)				37			6		0	0	0.069234	0	0
VPS13A	23230	broad.mit.edu	37	9	79981712	79981712	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:79981712A>C	uc004akr.3	+	60	8655	c.8395A>C	c.(8395-8397)Att>Ctt	p.I2799L	VPS13A_uc004akp.4_Missense_Mutation_p.I2799L|VPS13A_uc004akq.4_Missense_Mutation_p.I2799L|VPS13A_uc004aks.3_Missense_Mutation_p.I2760L	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	Homo sapiens vacuolar protein sorting 13 homolog A (S. cerevisiae) (VPS13A), transcript variant A, mRNA.	2799					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TGGAGGACTGATTCCAGTTCA	0.313000														18			16		0	0	0.033300	0	0
ARID5B	84159	broad.mit.edu	37	10	63852307	63852307	+	Silent	SNP	C	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr10:63852307C>A	uc001jlt.2	+	9	3541	c.3085C>A	c.(3085-3087)Cgg>Agg	p.R1029R	ARID5B_uc001jlu.2_Silent_p.R786R	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	Homo sapiens AT rich interactive domain 5B (MRF1-like) (ARID5B), transcript variant 1, mRNA.	1029					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding	p.R1029W(2)		NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					GAAAAAGGCCCGGGCAGTGTC	0.597000														72			37		1.04594e-18	1.46099e-18	0.086207	1	0
KBTBD5	131377	broad.mit.edu	37	3	42727131	42727131	+	Silent	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:42727131G>A	uc003clv.1	+	0	121	c.21G>A	c.(19-21)caG>caA	p.Q7Q		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	Homo sapiens kelch repeat and BTB (POZ) domain containing 5 (KBTBD5), mRNA.	7										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GCTTGGAGCAGGCGGAGGAGC	0.647000														7			7		0	0	0.038147	0	0
CAPN1	823	broad.mit.edu	37	11	64974118	64974118	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:64974118T>G	uc009yqd.2	+	12	1735	c.1538T>G	c.(1537-1539)tTc>tGc	p.F513C	CAPN1_uc001odf.2_Missense_Mutation_p.F513C|CAPN1_uc001odg.2_Missense_Mutation_p.F513C|CAPN1_uc010roa.2_Missense_Mutation_p.F254C	NM_001198868	NP_001185797	P07384	CAN1_HUMAN	Homo sapiens calpain 1, (mu/I) large subunit (CAPN1), transcript variant 1, mRNA.	513	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		GTGCTGCGCTTCTTCTCAGAG	0.652000														35			10		0	0	0.069234	0	0
GOLGA6L5	374650	broad.mit.edu	37	15	85056021	85056021	+	RNA	SNP	T	C	C	rs1062001		TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr15:85056021T>C	uc002bkm.2	-	5		c.539A>G								Homo sapiens golgin A6 family-like 5 (pseudogene) (GOLGA6L5), non-coding RNA.																		GTAGCTGCTCTACCTTAGATG	0.502000														7			4		0	0	0.009096	0	0
H2AFJ	55766	broad.mit.edu	37	12	14927594	14927594	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr12:14927594C>G	uc009zia.3	+	0	325	c.190C>G	c.(190-192)Ctg>Gtg	p.L64V	H2AFJ_uc001rch.4_Non-coding_Transcript	NM_177925	NP_808760	Q9BTM1	H2AJ_HUMAN	Homo sapiens H2A histone family, member J (H2AFJ), transcript variant 1, mRNA.	64					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|central_nervous_system(1)|kidney(1)|ovary(1)|skin(1)	5						GGCGGAGATCCTGGAGCTGGC	0.632000														63			28		0	0	0.050027	0	0
TUBB1	81027	broad.mit.edu	37	20	57597910	57597910	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr20:57597910T>C	uc002yak.3	+	1	337	c.68T>C	c.(67-69)aTg>aCg	p.M23T		NM_030773	NP_110400	Q9H4B7	TBB1_HUMAN	Homo sapiens tubulin, beta 1 class VI (TUBB1), mRNA.	23					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|skin(2)	16	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	TTCTGGGAGATGATTGGTGAG	0.547000														32			37		0	0	0.104719	0	0
CUBN	8029	broad.mit.edu	37	10	17127627	17127627	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr10:17127627T>G	uc001ioo.3	-	15	2131	c.2079A>C	c.(2077-2079)caA>caC	p.Q693H		NM_001081	NP_001072	O60494	CUBN_HUMAN	Homo sapiens cubilin (intrinsic factor-cobalamin receptor) (CUBN), mRNA.	693	CUB 2.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TATGGAAGCCTTGGTCACTAA	0.463000														85			55		0	0	0.139131	0	0
SMC5	23137	broad.mit.edu	37	9	72913102	72913102	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:72913102G>C	uc004ahr.2	+	8	1391	c.1274G>C	c.(1273-1275)cGa>cCa	p.R425P		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	Homo sapiens structural maintenance of chromosomes 5 (SMC5), mRNA.	425					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(4)	35						ATTGATAAGCGAAGAGAGAGG	0.358000														48			25		0	0	0.125774	0	0
PDCL	5082	broad.mit.edu	37	9	125582792	125582792	+	Nonsense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:125582792G>A	uc004bmz.2	-	3	669	c.478C>T	c.(478-480)Cag>Tag	p.Q160*		NM_005388	NP_005379	Q13371	PHLP_HUMAN	Homo sapiens phosducin-like (PDCL), mRNA.	160					signal transduction|visual perception					endometrium(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10						TCAAAAACCTGCTTGAATTGG	0.443000														86			52		0	0	0.139131	0	0
FOCAD	54914	broad.mit.edu	37	9	20990148	20990148	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:20990148T>A	uc003zog.1	+	43	5394	c.5031T>A	c.(5029-5031)ttT>ttA	p.F1677L	FOCAD_uc003zoh.1_Missense_Mutation_p.F1113L	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	Homo sapiens KIAA1797 (KIAA1797), mRNA.	1677						integral to membrane	binding										TGCTGATATTTGCAACCGCAG	0.488000														41			31		0	0	0.069456	0	0
CAMK2A	815	broad.mit.edu	37	5	149644564	149644564	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr5:149644564C>G	uc003lru.2	-	2	387	c.172G>C	c.(172-174)Gag>Cag	p.E58Q	CAMK2A_uc003lrt.2_Missense_Mutation_p.E58Q|CAMK2A_uc010jhe.2_Intron	NM_171825	NP_741960	Q9UQM7	KCC2A_HUMAN	Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 2, mRNA.	58	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTTCACGCTCCAGCTTCTGA	0.607000														39			16		0	0	0.038395	0	0
LIPE	3991	broad.mit.edu	37	19	42914668	42914668	+	Missense_Mutation	SNP	G	A	A	rs138983180	byFrequency	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr19:42914668G>A	uc002otr.3	-	1	1487	c.1210C>T	c.(1210-1212)Cgc>Tgc	p.R404C	AK311181_uc010eif.1_Intron|LIPE_uc002ots.1_Missense_Mutation_p.R149C	NM_005357	NP_005348	Q05469	LIPS_HUMAN	Homo sapiens lipase, hormone-sensitive (LIPE), mRNA.	404					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				TGGCTGGTGCGGAAGAAGATG	0.657000														38			3		0	0	0.115264	0	0
SLC37A1	54020	broad.mit.edu	37	21	43963563	43963563	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr21:43963563G>A	uc002zbj.3	+	7	1563	c.581G>A	c.(580-582)gGg>gAg	p.G194E	SLC37A1_uc002zbi.3_Missense_Mutation_p.G194E	NM_018964	NP_061837	P57057	GLPT_HUMAN	Homo sapiens solute carrier family 37 (glycerol-3-phosphate transporter), member 1 (SLC37A1), mRNA.	194					carbohydrate transport|transmembrane transport	integral to membrane				breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(3)	15						TTGATTATGGGGGTCTGGAAC	0.572000														135			63		0	0	0.139131	0	0
BAHCC1	57597	broad.mit.edu	37	17	79425869	79425869	+	Nonsense_Mutation	SNP	G	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr17:79425869G>T	uc002kaf.2	+	18	5293	c.5293G>T	c.(5293-5295)Gaa>Taa	p.E1765*	BAHCC1_uc002kae.2_Nonsense_Mutation_p.E1057*	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	Homo sapiens BAH domain and coiled-coil containing 1 (BAHCC1), mRNA.	1827							DNA binding			breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(5)|urinary_tract(1)	26	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CCGCCTGCTGGAAAGCTTCGC	0.662000														24			8		0.000274275	0.000360242	0.047766	1	0
ZNF385B	151126	broad.mit.edu	37	2	180310448	180310448	+	Frame_Shift_Del	DEL	T	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr2:180310448delT	uc002unn.4	-	7	1528	c.924delA	c.(922-924)aaafs	p.K308fs	ZNF385B_uc002unj.3_Frame_Shift_Del_p.K206fs|ZNF385B_uc002unl.3_Frame_Shift_Del_p.K205fs|ZNF385B_uc002unk.3_Non-coding_Transcript|ZNF385B_uc002unm.3_Frame_Shift_Del_p.K232fs	NM_152520	NP_001106869	Q569K4	Z385B_HUMAN	Homo sapiens zinc finger protein 385B (ZNF385B), transcript variant 1, mRNA.	308						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TGGTCTTGTGTTTAGATCCTA	0.388													---	61	---	---	30	---					
OBSL1	23363	broad.mit.edu	37	2	220435527	220435528	+	Frame_Shift_Ins	INS	-	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr2:220435527_220435528insC	uc010fwk.3	-	0	741_742	c.427_428insG	c.(427-429)gcgfs	p.A143fs	OBSL1_uc010fwl.2_Frame_Shift_Ins_p.A143fs|OBSL1_uc002vmi.3_Frame_Shift_Ins_p.A143fs|INHA_uc002vmk.2_5'Flank	NM_015311	NP_056126	O75147	OBSL1_HUMAN	Homo sapiens obscurin-like 1 (OBSL1), transcript variant 1, mRNA.	143	Ig-like 2.				cardiac myofibril assembly	M band|Z disc|intercalated disc|perinuclear region of cytoplasm	cytoskeletal adaptor activity						Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CACCACCTCCGCCCCCCGCAGC	0.748													---	4	---	---	2	---					
TOP2B	7155	broad.mit.edu	37	3	25678710	25678710	+	Frame_Shift_Del	DEL	T	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:25678710delT	uc011awn.1	-	5	678	c.635delA	c.(634-636)aagfs	p.K212fs	TOP2B_uc003cdj.2_Frame_Shift_Del_p.K207fs|TOP2B_uc021wug.1_Frame_Shift_Del_p.K207fs	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	Homo sapiens topoisomerase (DNA) II beta 180kDa (TOP2B), mRNA.	212					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	DNA topoisomerase complex (ATP-hydrolyzing)|WINAC complex|cytosol|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|chromatin binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						GCATACCTGCTTAAAACTGTG	0.333													---	4	---	---	2	---					
NEK10	152110	broad.mit.edu	37	3	27161285	27161286	+	In_Frame_Ins	INS	-	GAT	GAT	rs148975819		TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:27161285_27161286insGAT	uc010hfk.3	-	13	1491_1492	c.1262_1263insATC	c.(1261-1263)tcc>tcATCc	p.421_421S>SS	NEK10_uc010hfj.3_In_Frame_Ins_p.364_364S>SS			Q6ZWH5	NEK10_HUMAN	Homo sapiens NIMA (never in mitosis gene a)- related kinase 10 (NEK10), mRNA.	1109							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TGTTTCCACCGGATGAACGATG	0.401													---	87	---	---	49	---					
H1FOO	132243	broad.mit.edu	37	3	129268107	129268108	+	Frame_Shift_Ins	INS	-	A	A	rs150160917	by1000genomes	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:129268107_129268108insA	uc003emu.3	+	2	647_648	c.642_643insA	c.(640-645)gctaggfs	p.A214fs	H1FOO_uc003emv.3_Frame_Shift_Ins_p.A75fs	NM_153833	NP_722575	Q8IZA3	H1FOO_HUMAN	Homo sapiens H1 histone family, member O, oocyte-specific (H1FOO), mRNA.	214					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			endometrium(1)|lung(4)|skin(1)	6						CGGGAGAGGCTAGGAAGGTGCC	0.653													---	5	---	---	3	---					
ZNF318	24149	broad.mit.edu	37	6	43323502	43323502	+	Frame_Shift_Del	DEL	T	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr6:43323502delT	uc003oux.3	-	3	1648	c.1570delA	c.(1570-1572)aggfs	p.R524fs	ZNF318_uc003ouw.3_Non-coding_Transcript	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	Homo sapiens zinc finger protein 318 (ZNF318), mRNA.	524					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTACGTCGCCTTTTTTCCTGT	0.493													---	440	---	---	7	---					
VPS37D	155382	broad.mit.edu	37	7	73083913	73083921	+	Splice_Site	DEL	GCGACTGGG	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr7:73083913_73083921delGCGACTGGG	uc003tyr.3	+	2	425	c.310_splice	c.e2+1	p.E104_splice		NM_001077621	NP_001071089	Q86XT2	VP37D_HUMAN	Homo sapiens vacuolar protein sorting 37 homolog D (S. cerevisiae) (VPS37D), mRNA.	104	VPS37 C-terminal.				cellular membrane organization|endosome transport|protein transport	late endosome membrane				central_nervous_system(1)|ovary(1)	2		Lung NSC(55;0.0908)|all_lung(88;0.198)				ACAAGCTGCAGCGACTGGGTGAGGGCACG	0.675													---	4	---	---	3	---					
OR8D4	338662	broad.mit.edu	37	11	123777441	123777442	+	Frame_Shift_Ins	INS	-	T	T	rs79561639	byFrequency	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:123777441_123777442insT	uc010saa.2	+	0	303_304	c.303_304insT	c.(301-306)ctgtttfs	p.L101fs		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	Homo sapiens olfactory receptor, family 8, subfamily D, member 4 (OR8D4), mRNA.	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TGATTCAGCTGTTTTTTTTCTG	0.436													---	350	---	---	8	---					
NEDD4	4734	broad.mit.edu	37	15	56208931	56208934	+	Frame_Shift_Del	DEL	CATG	-	-	rs1912403	byFrequency	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr15:56208931_56208934delCATG	uc002adj.3	-	0	396_399	c.96_99delCATG	c.(94-99)cacatgfs	p.H32fs	NEDD4_uc002adl.3_Intron|NEDD4_uc002adi.3_Frame_Shift_Del_p.H32fs|NEDD4_uc010ugj.2_Frame_Shift_Del_p.H32fs|NEDD4_uc010bfm.3_Frame_Shift_Del_p.H32fs|NEDD4_uc002adk.3_Non-coding_Transcript	NM_198400	NP_006145	P46934	NEDD4_HUMAN	Homo sapiens neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 2, mRNA.	32					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	RNA polymerase binding|beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		TTTTGAAGCACATGTGAACATGGC	0.436													---	150	---	---	67	---					
CORO1A	11151	broad.mit.edu	37	16	30198546	30198547	+	Splice_Site	INS	-	GA	GA			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr16:30198546_30198547insGA	uc010bzq.3	+	6	1071	c.636_splice	c.e6+2	p.A212_splice	BOLA2_uc010bzb.1_Intron|CORO1A_uc002dww.3_Splice_Site_p.A212_splice|CORO1A_uc002dwx.3_Splice_Site_p.A106_splice|CORO1A_uc002dwy.1_Splice_Site_p.A56_splice|CORO1A_uc002dwz.1_5'Flank	NM_001193333	NP_009005	P31146	COR1A_HUMAN	Homo sapiens coronin, actin binding protein, 1A (CORO1A), transcript variant 1, mRNA.	212					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	9						GTCGTAGCTGTGAGTCGCCATC	0.589													---	54	---	---	21	---					
SON	6651	broad.mit.edu	37	21	34927198	34927198	+	Frame_Shift_Del	DEL	A	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr21:34927198delA	uc002yse.1	+	2	5710	c.5661delA	c.(5659-5661)tcafs	p.S1887fs	SON_uc002ysb.1_Frame_Shift_Del_p.S1887fs|SON_uc002ysc.3_Frame_Shift_Del_p.S1887fs|SON_uc002ysd.3_Frame_Shift_Del_p.S878fs|SON_uc002ysf.1_Intron|SON_uc002ysg.3_Frame_Shift_Del_p.S878fs	NM_138927	NP_620305	P18583	SON_HUMAN	Homo sapiens SON DNA binding protein (SON), transcript variant f, mRNA.	1887					RNA splicing|anti-apoptosis|cytokinesis|mRNA processing|regulation of RNA splicing|regulation of cell cycle|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						GATCTGTATCAAAAGAGAAGC	0.453													---	27	---	---	15	---					
GPR174	84636	broad.mit.edu	37	X	78427128	78427128	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chrX:78427128delG	uc004edg.1	+	0	660	c.624delG	c.(622-624)acgfs	p.T208fs		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	Homo sapiens G protein-coupled receptor 174 (GPR174), mRNA.	208						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						CCTGGAAGACGGTTTTATCAC	0.438										HNSCC(63;0.18)			---	92	---	---	60	---					
