Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF514	84874	broad.mit.edu	37	2	95815137	95815137	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr2:95815137A>C	uc002sud.1	-	4	1683	c.1312T>G	c.(1312-1314)Ttt>Gtt	p.F438V	ZNF514_uc002sue.1_Missense_Mutation_p.F365V	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	Homo sapiens zinc finger protein 514 (ZNF514), mRNA.	365					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(6)|urinary_tract(1)	11						CCAGTGTGAAATCTGTAATGT	0.398000														39			30		0	0	0.041601	0	0
KRT26	353288	broad.mit.edu	37	17	38926071	38926071	+	Nonsense_Mutation	SNP	C	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr17:38926071C>A	uc002hvf.3	-	4	950	c.904G>T	c.(904-906)Gag>Tag	p.E302*		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	Homo sapiens keratin 26 (KRT26), mRNA.	302	Coil 2.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(5)	16		Breast(137;0.00526)				TCGGTCAGCTCATTTCTGGCT	0.463000														132			60		8.13277e-46	9.36813e-46	0.048971	1	0
LARP4	113251	broad.mit.edu	37	12	50847454	50847454	+	Splice_Site	SNP	T	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr12:50847454T>C	uc001rwp.2	+	9	1219	c.1017_splice	c.e9+1	p.L339_splice	LARP4_uc001rwq.2_Intron|LARP4_uc001rwt.2_Intron|LARP4_uc001rws.2_Splice_Site_p.L338_splice|LARP4_uc001rwr.2_Splice_Site_p.L339_splice|LARP4_uc021qxv.1_Splice_Site_p.L269_splice|LARP4_uc009zlr.1_Splice_Site_p.L158_splice|LARP4_uc001rwm.3_Splice_Site_p.L339_splice|LARP4_uc001rwn.3_Splice_Site_p.L269_splice	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	Homo sapiens La ribonucleoprotein domain family, member 4 (LARP4), transcript variant 1, mRNA.	339							RNA binding|nucleotide binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						GAAACACCACTGGTAAGTGAG	0.353000														56			54		0	0	0.048971	0	0
UQCR10	29796	broad.mit.edu	37	22	30163434	30163434	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr22:30163434G>A	uc003agq.1	+	0	77	c.47G>A	c.(46-48)cGc>cAc	p.R16H	ZMAT5_uc003agm.3_5'Flank|ZMAT5_uc003agn.3_5'Flank|ZMAT5_uc003ago.1_5'Flank|UQCR10_uc003agp.1_Missense_Mutation_p.R16H|UQCR10_uc021wns.1_Missense_Mutation_p.R16H	NM_013387	NP_037519	Q9UDW1	QCR9_HUMAN	Homo sapiens ubiquinol-cytochrome c reductase, complex III subunit X (UQCR10), transcript variant 1, mRNA.	16					mitochondrial electron transport, ubiquinol to cytochrome c	mitochondrial inner membrane|respiratory chain	ubiquinol-cytochrome-c reductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)	5						CTGCTGTTCCGCAGGACCTCC	0.612000														28			25		0	0	0.091800	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52961169	52961169	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr1:52961169T>C	uc001cty.2	-	5	1449	c.1196A>G	c.(1195-1197)tAt>tGt	p.Y399C	ZCCHC11_uc001ctx.2_Missense_Mutation_p.Y399C|ZCCHC11_uc009vze.1_Missense_Mutation_p.Y399C|ZCCHC11_uc009vzf.1_Missense_Mutation_p.Y158C|ZCCHC11_uc001cub.3_Missense_Mutation_p.Y399C|ZCCHC11_uc001cuc.2_Non-coding_Transcript	NM_001009881	NP_001009881	Q5TAX3	TUT4_HUMAN	Homo sapiens zinc finger, CCHC domain containing 11 (ZCCHC11), transcript variant 1, mRNA.	399					RNA 3'-end processing|miRNA catabolic process|pre-miRNA processing|stem cell maintenance	cytoplasm|nucleolus	RNA uridylyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						AGATGAGCCATACAACCTAAG	0.338000														30			25		0	0	0.091800	0	0
SACM1L	22908	broad.mit.edu	37	3	45780273	45780273	+	Splice_Site	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr3:45780273G>A	uc003cos.2	+	18	1681	c.1477_splice	c.e18-1	p.D493_splice	SACM1L_uc011bag.1_Splice_Site_p.D390_splice|SACM1L_uc011bah.1_Splice_Site_p.D427_splice|SACM1L_uc003cot.2_Splice_Site_p.D136_splice	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	Homo sapiens SAC1 suppressor of actin mutations 1-like (yeast) (SACM1L), mRNA.	493						Golgi apparatus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		TCTGTTCTAGGATTCCATAGA	0.363000														23			29		0	0	0.030593	0	0
PEX14	5195	broad.mit.edu	37	1	10678475	10678475	+	Splice_Site	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr1:10678475G>A	uc001arn.3	+	5	405	c.384_splice	c.e5+1	p.K128_splice	PEX14_uc009vmu.1_Splice_Site_p.K85_splice|PEX14_uc009vmv.3_Splice_Site_p.K64_splice|PEX14_uc010oam.2_Splice_Site_p.K64_splice|PEX14_uc010oan.2_Splice_Site_p.K85_splice|PEX14_uc009vmw.3_Splice_Site_p.K64_splice	NM_004565	NP_004556	O75381	PEX14_HUMAN	Homo sapiens peroxisomal biogenesis factor 14 (PEX14), mRNA.	128					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(3)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	13	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		GCTCTACAAGGTGAGTCACCC	0.627000														19			13		0	0	0.105934	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834204	101834204	+	Silent	SNP	C	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr5:101834204C>A	uc003knn.3	-	0	517	c.345G>T	c.(343-345)ctG>ctT	p.L115L	SLCO6A1_uc003kno.3_Silent_p.L115L|SLCO6A1_uc003knp.3_Silent_p.L115L|SLCO6A1_uc003knq.3_Silent_p.L115L	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	Homo sapiens solute carrier organic anion transporter family, member 6A1 (SLCO6A1), mRNA.	115	Cys-rich.					integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		GACATATGAGCAGGATGCAGT	0.572000														37			33		1.80694e-10	1.95752e-10	0.041601	1	0
ANGPTL6	83854	broad.mit.edu	37	19	10206815	10206815	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr19:10206815C>T	uc002mmy.1	-	1	617	c.425G>A	c.(424-426)cGc>cAc	p.R142H	ANGPTL6_uc002mmx.2_Missense_Mutation_p.R142H	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	Homo sapiens angiopoietin-like 6 (ANGPTL6), mRNA.	142					angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)	12			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			GTTGAGCACGCGCTCCCCGAG	0.771000														5			3		0	0	0.004672	0	0
LOC650368	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr11:3427845C>T	uc010qxs.1	+	8		c.838C>T			LOC650368_uc001lxy.2_Non-coding_Transcript					Homo sapiens asparagine-linked glycosylation 1-like pseudogene (LOC650368), non-coding RNA.																		CTTCAAGTGGCAGGAGCAGAA	0.587000														44			7		0	0	0.029380	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	568988	568988	+	Silent	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr16:568988G>A	uc002chf.3	+	9	2025	c.1686G>A	c.(1684-1686)acG>acA	p.T562T	RAB11FIP3_uc010uuf.2_Silent_p.T266T|RAB11FIP3_uc010uug.2_Silent_p.T297T	NM_014700	NP_055515	O75154	RFIP3_HUMAN	Homo sapiens RAB11 family interacting protein 3 (class II) (RAB11FIP3), transcript variant 1, mRNA.	562	ARF-binding domain (ABD).				cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|Rab GTPase binding|calcium ion binding|protein homodimerization activity			breast(1)|endometrium(2)|kidney(3)|lung(5)|upper_aerodigestive_tract(1)	12		Hepatocellular(16;0.0218)				GGTCCTGCACGCCCTGTCTGA	0.612000														81			30		0	0	0.045705	0	0
C9orf69	90120	broad.mit.edu	37	9	139008421	139008421	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr9:139008421C>T	uc004cgx.4	-	1	851	c.400G>A	c.(400-402)Gcc>Acc	p.A134T	C9orf69_uc004cgy.2_Non-coding_Transcript	NM_152833	NP_690046			Homo sapiens chromosome 9 open reading frame 69 (C9orf69), mRNA.											endometrium(1)	1		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.58e-07)|Epithelial(140;6.42e-06)		GTTCACCAGGCGGAAGTCCAC	0.657000														11			11		0	0	0.080935	0	0
IL9	3578	broad.mit.edu	37	5	135228124	135228124	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr5:135228124T>C	uc003lbb.1	-	4	402	c.391A>G	c.(391-393)Att>Gtt	p.I131V		NM_000590	NP_000581	P15248	IL9_HUMAN	Homo sapiens interleukin 9 (IL9), mRNA.	131					immune response|inflammatory response|positive regulation of cell proliferation|positive regulation of interleukin-5 biosynthetic process	extracellular space	cytokine activity|cytokine receptor binding|growth factor activity	p.I131I(1)		large_intestine(3)|lung(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTCTGGAAAATTTCCAGAAGA	0.368000														24			20		0	0	0.055883	0	0
WDR91	29062	broad.mit.edu	37	7	134873248	134873248	+	Silent	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr7:134873248C>T	uc003vsp.2	-	12	1880	c.1818G>A	c.(1816-1818)gaG>gaA	p.E606E	WDR91_uc010lmr.2_Intron|WDR91_uc010lmq.2_Silent_p.E195E	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	Homo sapiens WD repeat domain 91 (WDR91), mRNA.	606								p.G605W(1)		breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						CAGAGTAGACCTCCCCGTAGT	0.592000														198			53		0	0	0.048971	0	0
TMEM120A	83862	broad.mit.edu	37	7	75617074	75617074	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr7:75617074C>T	uc003ued.3	-	9	847	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TMEM120A_uc003ueb.1_Missense_Mutation_p.R35Q|TMEM120A_uc003uec.2_Missense_Mutation_p.R153Q	NM_031925	NP_114131	Q9BXJ8	T120A_HUMAN	Homo sapiens transmembrane protein 120A (TMEM120A), mRNA.	249						integral to membrane											GCCCAGCGCCCGCAGGCGGTA	0.672000														24			7		0	0	0.047766	0	0
MAPK6	5597	broad.mit.edu	37	15	52338881	52338881	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr15:52338881A>G	uc002abp.3	+	1	1018	c.224A>G	c.(223-225)gAt>gGt	p.D75G		NM_002748	NP_002739	Q16659	MK06_HUMAN	Homo sapiens mitogen-activated protein kinase 6 (MAPK6), mRNA.	75	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		CTTGACCATGATAACATTGTG	0.398000														66			42		0	0	0.092188	0	0
CATSPER1	117144	broad.mit.edu	37	11	65788966	65788966	+	Splice_Site	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr11:65788966C>T	uc001ogt.3	-	4	1829	c.1691_splice	c.e4+1	p.S564_splice		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	Homo sapiens cation channel, sperm associated 1 (CATSPER1), mRNA.	564					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						TGGCCACTGACCTGAGCCTCC	0.627000														12			9		0	0	0.080935	0	0
GRASP	160622	broad.mit.edu	37	12	52401016	52401016	+	Silent	SNP	C	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr12:52401016C>A	uc001rzo.1	+	0	269	c.213C>A	c.(211-213)ctC>ctA	p.L71L		NM_181711	NP_859062	Q7Z6J2	GRASP_HUMAN	Homo sapiens GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein (GRASP), mRNA.	71						cell junction|perinuclear region of cytoplasm|postsynaptic membrane				central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				BRCA - Breast invasive adenocarcinoma(357;0.0967)		ACCGCGCGCTCGCCGTGTCCG	0.741000														8			12		0.00136819	0.00141484	0.093190	1	0
TBC1D3P5	440419	broad.mit.edu	37	17	25746859	25746859	+	RNA	SNP	T	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr17:25746859T>C	uc021ttg.1	+	2		c.1711T>C			TBC1D3P5_uc002gzg.3_Non-coding_Transcript					Homo sapiens TBC1 domain family, member 3 pseudogene 5 (TBC1D3P5), non-coding RNA.																		ACAGCAGCACTGATCGCTTTG	0.537000														21			6		0	0	0.029380	0	0
ANKRD20A9P	284232	broad.mit.edu	37	13	19414102	19414102	+	RNA	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr13:19414102C>T	uc010tcj.1	-	0		c.32008G>A								Homo sapiens ankyrin repeat domain 20 family, member A9, pseudogene (ANKRD20A9P), non-coding RNA.																		GAATTTTTACCAAAGATTGAT	0.274000														26			4		0	0	0.009096	0	0
TNFSF15	9966	broad.mit.edu	37	9	117552848	117552848	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr9:117552848G>A	uc004bjh.3	-	3	756	c.640C>T	c.(640-642)Ctc>Ttc	p.L214F	TNFSF15_uc004bjg.3_Missense_Mutation_p.L155F	NM_005118	NP_005109	O95150	TNF15_HUMAN	Homo sapiens tumor necrosis factor (ligand) superfamily, member 15 (TNFSF15), transcript variant 1, mRNA.	214					activation of NF-kappaB-inducing kinase activity|activation of caspase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding	p.L214L(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						ATGGCTCCGAGGTAGATGGGC	0.493000														49			36		0	0	0.069456	0	0
EVI2A	2123	broad.mit.edu	37	17	29645740	29645740	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr17:29645740A>T	uc002hgl.3	-	2	698	c.361T>A	c.(361-363)Tct>Act	p.S121T	NF1_uc002hgg.3_Intron|NF1_uc002hgh.3_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.3_Intron|EVI2A_uc002hgm.3_Missense_Mutation_p.S98T|EVI2A_uc021tul.1_Missense_Mutation_p.S98T	NM_001003927	NP_055025	P22794	EVI2A_HUMAN	Homo sapiens ecotropic viral integration site 2A (EVI2A), transcript variant 1, mRNA.	98						integral to membrane	transmembrane receptor activity	p.0?(8)|p.?(3)|p.S121P(2)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;5.94e-13)|Epithelial(4;7.98e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.4e-12)|GBM - Glioblastoma multiforme(4;0.18)		CTGACGACAGAAGGTATATAA	0.368000														72			104		0	0	0.048971	0	0
VCPIP1	80124	broad.mit.edu	37	8	67577113	67577113	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr8:67577113A>G	uc003xwn.3	-	0	2340	c.2081T>C	c.(2080-2082)cTt>cCt	p.L694P	SGK3_uc003xwp.3_5'Flank|C8orf44_uc003xwo.2_5'Flank	NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	Homo sapiens valosin containing protein (p97)/p47 complex interacting protein 1 (VCPIP1), mRNA.	694					protein ubiquitination	Golgi stack|endoplasmic reticulum	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			CTGTCCAGTAAGAATAATTTT	0.373000														84			55		0	0	0.048971	0	0
MFSD10	10227	broad.mit.edu	37	4	2934166	2934166	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr4:2934166A>G	uc003gfw.3	-	4	919	c.605T>C	c.(604-606)aTg>aCg	p.M202T	MFSD10_uc021xks.1_Missense_Mutation_p.M126T|MFSD10_uc003gfz.3_Missense_Mutation_p.M202T|NOP14-AS1_uc003ggd.1_5'Flank|NOP14-AS1_uc003gge.1_5'Flank	NM_001120	NP_001139541	Q14728	MFS10_HUMAN	Homo sapiens major facilitator superfamily domain containing 10 (MFSD10), transcript variant 1, mRNA.	202					apoptosis	integral to membrane	tetracycline transporter activity			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCAGGGTGCCATTTCCAGGGG	0.632000														31			21		0	0	0.076483	0	0
TCP11	6954	broad.mit.edu	37	6	35088271	35088271	+	Missense_Mutation	SNP	T	C	C	rs62404564	byFrequency	TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr6:35088271T>C	uc003okd.2	-	6	1088	c.907A>G	c.(907-909)Atg>Gtg	p.M303V	TCP11_uc003ojz.1_Missense_Mutation_p.M228V|TCP11_uc003oka.2_Missense_Mutation_p.M228V|TCP11_uc003okb.2_Missense_Mutation_p.M227V|TCP11_uc011dsu.1_Missense_Mutation_p.M285V|TCP11_uc003okc.2_Missense_Mutation_p.M227V|TCP11_uc011dsv.1_Missense_Mutation_p.M252V|TCP11_uc011dsw.1_Missense_Mutation_p.M257V	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	Homo sapiens t-complex 11 homolog (mouse) (TCP11), transcript variant 1, mRNA.	290					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						CACAGCACCATTGTGGGGCTG	0.557000														132			5		0	0	0.014758	0	0
X97876	0	broad.mit.edu	37	9	66500841	66500841	+	RNA	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr9:66500841C>T	uc004aed.1	+	2		c.934C>T								Homo sapiens uncharacterized LOC442421 (LOC442421), non-coding RNA.																		CCACCTGGTGCCCAGGGCTCC	0.632000														26			3		0	0	0.021553	0	0
LMTK3	114783	broad.mit.edu	37	19	49000760	49000760	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr19:49000760G>A	uc002pjk.3	-	11	3653	c.3653C>T	c.(3652-3654)aCg>aTg	p.T1218M		NM_001080434	NP_001073903			Homo sapiens lemur tyrosine kinase 3 (LMTK3), mRNA.											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GCTGAGTGCCGTGTCTCCGCC	0.726000														32			3		0	0	0.004672	0	0
SCLY	51540	broad.mit.edu	37	2	238990470	238990470	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr2:238990470T>C	uc010fyv.3	+	4	736	c.605T>C	c.(604-606)aTt>aCt	p.I202T	SCLY_uc002vxm.4_Missense_Mutation_p.I169T|SCLY_uc010znr.2_Missense_Mutation_p.I108T|SCLY_uc010znq.2_Intron	NM_016510	NP_057594	Q96I15	SCLY_HUMAN	Homo sapiens selenocysteine lyase (SCLY), mRNA.	202					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	22		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		GAGACTGGCATTGTCATGGTG	0.572000														27			19		0	0	0.038395	0	0
SLC35A4	113829	broad.mit.edu	37	5	139947279	139947279	+	Silent	SNP	T	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr5:139947279T>A	uc003lgg.1	+	2	1253	c.525T>A	c.(523-525)gcT>gcA	p.A175A	SLC35A4_uc003lgh.1_Silent_p.A175A|SLC35A4_uc021yei.1_Silent_p.A175A	NM_080670	NP_542401	Q96G79	S35A4_HUMAN	Homo sapiens solute carrier family 35, member A4 (SLC35A4), mRNA.	175	Leu-rich.					Golgi membrane|integral to membrane	sugar:hydrogen symporter activity			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCAGCAGCTGCTGCCAGCC	0.622000														36			30		0	0	0.045705	0	0
THOC2	57187	broad.mit.edu	37	X	122756985	122756985	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chrX:122756985T>A	uc004etu.3	-	28	3685	c.3653A>T	c.(3652-3654)aAa>aTa	p.K1218I	THOC2_uc010nqt.1_5'Flank|THOC2_uc004etw.1_Missense_Mutation_p.K39I	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	Homo sapiens THO complex 2 (THOC2), mRNA.	1218					RNA splicing|intronless viral mRNA export from host nucleus|mRNA processing	THO complex part of transcription export complex	RNA binding|protein binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						TTCATCCGATTTAGATGCACT	0.403000														6			53		0	0	0.048971	0	0
GALNT2	2590	broad.mit.edu	37	1	230372159	230372159	+	Silent	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr1:230372159C>T	uc010pwa.1	+	4	606	c.534C>T	c.(532-534)agC>agT	p.S178S	GALNT2_uc010pvy.1_Silent_p.S140S|GALNT2_uc010pvz.1_Non-coding_Transcript	NM_004481	NP_004472	Q10471	GALT2_HUMAN	Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2) (GALNT2), mRNA.	178	Catalytic subdomain A.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|extracellular region|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				ATGACTACAGCAATGATCGTG	0.448000														39			17		0	0	0.049695	0	0
SRBD1	55133	broad.mit.edu	37	2	45616665	45616665	+	Silent	SNP	G	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr2:45616665G>C	uc002rus.3	-	20	2848	c.2772C>G	c.(2770-2772)ggC>ggG	p.G924G	SRBD1_uc010yoc.2_Silent_p.G443G	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	Homo sapiens S1 RNA binding domain 1 (SRBD1), mRNA.	924	S1 motif.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		RNA binding|hydrolase activity, acting on ester bonds			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			TCTCAACTTTGCCTGTAAGAA	0.378000														42			17		0	0	0.028581	0	0
ABCA11P	79963	broad.mit.edu	37	4	437056	437056	+	Silent	SNP	A	G	G			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr4:437056A>G	uc003gaf.4	-	2	1522	c.1296T>C	c.(1294-1296)agT>agC	p.S432S	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.2_Intron|ABCA11P_uc003gae.3_Intron|ABCA11P_uc010ibd.2_Intron|ABCA11P_uc003gag.3_Silent_p.S400S|ABCA11P_uc010ibe.3_Silent_p.S388S	NM_133474	NP_597731			Homo sapiens zinc finger protein 721 (ZNF721), mRNA.																		GGTTTGTTGAACTATTAAAGG	0.428000														28			23		0	0	0.069288	0	0
CARD8	22900	broad.mit.edu	37	19	48737764	48737764	+	Silent	SNP	A	G	G	rs2288876	by1000genomes	TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr19:48737764A>G	uc010xzj.2	-	2	289	c.246T>C	c.(244-246)ctT>ctC	p.L82L	CARD8_uc002pii.4_Silent_p.L82L|CARD8_uc010xzi.1_5'UTR|CARD8_uc010els.3_5'Flank|CARD8_uc010xzk.2_Missense_Mutation_p.F15S|CARD8_uc002pie.4_5'UTR|CARD8_uc002pif.4_5'UTR|CARD8_uc021uwq.1_5'UTR|CARD8_uc021uwr.1_5'UTR|CARD8_uc002pig.4_5'UTR|CARD8_uc002pih.4_Silent_p.L32L|CARD8_uc010xzl.2_Silent_p.L32L|CARD8_uc010xzm.2_Silent_p.L82L	NM_001184900	NP_001171829	Q9Y2G2	CARD8_HUMAN	Homo sapiens caspase recruitment domain family, member 8 (CARD8), transcript variant 1, mRNA.	0					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	NACHT domain binding|caspase activator activity|protein homodimerization activity			endometrium(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	15		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		AGATGTCACAAAGGGTCTCAG	0.438000														56			4		0	0	0.009096	0	0
MUC5B	727897	broad.mit.edu	37	11	1275533	1275533	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr11:1275533G>C	uc001lta.3	+	33	15488	c.15429G>C	c.(15427-15429)atG>atC	p.M5143I		NM_002458	NP_002449	Q9HC84	MUC5B_HUMAN	Homo sapiens mucin 5B, oligomeric mucus/gel-forming (MUC5B), mRNA.	5143	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACAAGTCCATGGATATCGTCC	0.642000														29			20		0	0	0.043863	0	0
ULK2	9706	broad.mit.edu	37	17	19770705	19770705	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr17:19770705T>A	uc002gwm.4	-	0	535	c.26A>T	c.(25-27)tAc>tTc	p.Y9F	ULK2_uc002gwn.3_Missense_Mutation_p.Y9F	NM_001142610	NP_055498	Q8IYT8	ULK2_HUMAN	Homo sapiens unc-51-like kinase 2 (C. elegans) (ULK2), transcript variant 2, mRNA.	9	Protein kinase.				signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					CCTCTTGCTGTACTCGAAGTC	0.771000														18			23		0	0	0.099896	0	0
PQLC1	80148	broad.mit.edu	37	18	77679262	77679262	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr18:77679262A>T	uc002lnl.2	-	4	702	c.530T>A	c.(529-531)cTg>cAg	p.L177Q	PQLC1_uc010dre.2_Missense_Mutation_p.L94Q|PQLC1_uc002lnk.2_Missense_Mutation_p.L159Q|PQLC1_uc010xfm.1_Intron	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	Homo sapiens PQ loop repeat containing 1 (PQLC1), transcript variant 1, mRNA.	177						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	9		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		CAGCACAGCCAGGAAGCCCAG	0.652000														29			18		0	0	0.033300	0	0
ANKRD28	23243	broad.mit.edu	37	3	15751227	15751227	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr3:15751227T>C	uc003caj.1	-	12	1407	c.1264A>G	c.(1264-1266)Aac>Gac	p.N422D	ANKRD28_uc003cai.1_Missense_Mutation_p.N268D|ANKRD28_uc011avz.1_Missense_Mutation_p.N268D|ANKRD28_uc003cak.1_Non-coding_Transcript|ANKRD28_uc011awa.1_Non-coding_Transcript|ANKRD28_uc003cal.1_Missense_Mutation_p.N452D|ANKRD28_uc003cam.2_Missense_Mutation_p.N455D	NM_015199	NP_001182028	O15084	ANR28_HUMAN	Homo sapiens ankyrin repeat domain 28 (ANKRD28), transcript variant 1, mRNA.	422						nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						AGCAGAAGGTTTAGGCACTCC	0.323000														6			8		0	0	0.047766	0	0
XKRX	402415	broad.mit.edu	37	X	100183205	100183205	+	Missense_Mutation	SNP	C	T	T	rs147872571	byFrequency	TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chrX:100183205C>T	uc004egn.2	-	0	694	c.89G>A	c.(88-90)cGa>cAa	p.R30Q	XKRX_uc011mre.1_5'UTR	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	Homo sapiens XK, Kell blood group complex subunit-related, X-linked (XKRX), mRNA.	30						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(3)	22						AAAAGTAAATCGGGGGTTGGC	0.443000														80			4		0	0	0.009096	0	0
LGALS12	85329	broad.mit.edu	37	11	63273900	63273900	+	Silent	SNP	G	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr11:63273900G>C	uc001nxc.2	+	0	377	c.36G>C	c.(34-36)acG>acC	p.T12T	LGALS12_uc001nxa.2_Silent_p.T12T|LGALS12_uc001nxb.2_Silent_p.T12T|LGALS12_uc001nxd.2_5'Flank|LGALS12_uc001nxe.2_5'Flank|LGALS12_uc009yot.2_5'Flank	NM_001142535	NP_001136007	Q96DT0	LEG12_HUMAN	Homo sapiens lectin, galactoside-binding, soluble, 12 (LGALS12), transcript variant 1, mRNA.	12					apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						CTCCTGGAACGAGGATCTACA	0.572000														71			4		0	0	0.014758	0	0
PRKDC	5591	broad.mit.edu	37	8	48744423	48744423	+	Silent	SNP	G	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr8:48744423G>T	uc003xqi.3	-	60	8271	c.8214C>A	c.(8212-8214)ctC>ctA	p.L2738L	PRKDC_uc003xqj.3_Silent_p.L2738L	NM_006904	NP_008835	P78527	PRKDC_HUMAN	Homo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 1, mRNA.	2739	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACATCAAACTGAGCTTCTCCT	0.532000								Non-homologous end-joining						100			67		2.26907e-38	2.58106e-38	0.048971	1	0
SULF2	55959	broad.mit.edu	37	20	46291842	46291842	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr20:46291842T>A	uc002xto.3	-	16	2672	c.2342A>T	c.(2341-2343)tAc>tTc	p.Y781F	SULF2_uc002xtr.3_Missense_Mutation_p.Y781F|SULF2_uc002xtq.3_Missense_Mutation_p.Y781F|SULF2_uc010zyd.2_Missense_Mutation_p.Y60F	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	Homo sapiens sulfatase 2 (SULF2), transcript variant 1, mRNA.	781					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	Golgi stack|cell surface|endoplasmic reticulum|extracellular space	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						GAGATCAAAGTACTCTAGGAA	0.547000											OREG0026005	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		42			45		0	0	0.045515	0	0
TMEM72	643236	broad.mit.edu	37	10	45429133	45429133	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr10:45429133G>C	uc001jbn.2	+	3	455	c.258G>C	c.(256-258)tgG>tgC	p.W86C	TMEM72-AS1_uc001jbk.1_Intron|TMEM72_uc009xmm.1_5'UTR	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	Homo sapiens transmembrane protein 72 (TMEM72), mRNA.	86						integral to membrane				breast(2)|kidney(1)|large_intestine(2)|lung(10)	15						AAGCCCACTGGCTGGGCTGCT	0.602000														21			24		0	0	0.076483	0	0
SLC26A1	10861	broad.mit.edu	37	4	983983	983983	+	Silent	SNP	T	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr4:983983T>C	uc003gcb.3	-	3	1122	c.744A>G	c.(742-744)acA>acG	p.T248T	SLC26A1_uc003gbx.3_Intron|IDUA_uc003gby.3_Intron|IDUA_uc003gbz.3_Intron|IDUA_uc003gca.3_Intron|SLC26A1_uc003gcc.3_Silent_p.T248T	NM_213613	NP_998778	Q9H2B4	S26A1_HUMAN	Homo sapiens solute carrier family 26 (sulfate transporter), member 1 (SLC26A1), transcript variant 3, mRNA.	248						integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|pancreas(1)|prostate(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GGCTCAGCCATGTGAGGACCA	0.697000														2			5		0	0	0.014758	0	0
SUN2	25777	broad.mit.edu	37	22	39138452	39138452	+	Silent	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr22:39138452G>A	uc011anz.2	-	9	1078	c.1027C>T	c.(1027-1029)Ctg>Ttg	p.L343L	SUN2_uc011aoa.2_Silent_p.L297L|SUN2_uc003awh.2_Silent_p.L308L|SUN2_uc010gxq.2_Silent_p.L329L|SUN2_uc003awi.2_Silent_p.L308L|SUN2_uc010gxr.2_Silent_p.L308L	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	Homo sapiens Sad1 and UNC84 domain containing 2 (SUN2), transcript variant 2, mRNA.	308					centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	SUN-KASH complex|endosome membrane|integral to membrane|nuclear inner membrane	lamin binding|microtubule binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(2)|stomach(1)	15						CGCAGCTCCAGACGTTCCAGC	0.647000														23			17		0	0	0.033300	0	0
TAF2	6873	broad.mit.edu	37	8	120816142	120816142	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr8:120816142G>A	uc003you.3	-	4	806	c.536C>T	c.(535-537)tCt>tTt	p.S179F		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa (TAF2), mRNA.	179					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(2)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(21)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	49	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATACCCACAAGAGAAAACATG	0.333000														75			60		0	0	0.048971	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117012	117012	+	RNA	SNP	C	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chrGL000205.1:117012C>A	uc002kgk.4	+	0		c.390C>A								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		ACCAAAGAAGCTGTATTCCCT	0.478000														7			4		0.00024832	0.000262757	0.009096	1	0
PIP5KL1	138429	broad.mit.edu	37	9	130684238	130684238	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr9:130684238C>T	uc011mao.2	-	9	1118	c.1073G>A	c.(1072-1074)cGg>cAg	p.R358Q	PIP5KL1_uc004bsu.3_Missense_Mutation_p.R155Q	NM_001135219	NP_001128691	Q5T9C9	PI5L1_HUMAN	Homo sapiens phosphatidylinositol-4-phosphate 5-kinase-like 1 (PIP5KL1), transcript variant 1, mRNA.	358	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|skin(1)	8						GTGCTCCAGCCGCTTGCGGAG	0.687000											OREG0019512	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		1			3		0	0	0.009096	0	0
RALGAPB	57148	broad.mit.edu	37	20	37153507	37153507	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr20:37153507C>A	uc002xiw.3	+	10	1963	c.1706C>A	c.(1705-1707)cCt>cAt	p.P569H	RALGAPB_uc010zvz.1_3'UTR|RALGAPB_uc002xix.3_Missense_Mutation_p.P569H|RALGAPB_uc002xiy.1_Missense_Mutation_p.P569H|RALGAPB_uc002xiz.3_Missense_Mutation_p.P347H|RALGAPB_uc002xja.1_Missense_Mutation_p.P296H	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Homo sapiens Ral GTPase activating protein, beta subunit (non-catalytic) (RALGAPB), mRNA.	569					activation of Ral GTPase activity	intracellular	Ral GTPase activator activity|protein heterodimerization activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						AACTCTCCTCCTTTGTTCTGC	0.393000														84			137		2.0029e-70	2.33672e-70	0.048971	1	0
DDX27	55661	broad.mit.edu	37	20	47835928	47835928	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr20:47835928A>C	uc002xuh.3	+	0	97	c.36A>C	c.(34-36)gaA>gaC	p.E12D		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (DDX27), mRNA.	12						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAGGCTGCGAAAAGTTAAGGG	0.607000														29			12		0	0	0.093190	0	0
MUC16	94025	broad.mit.edu	37	19	9077786	9077786	+	Silent	SNP	G	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr19:9077786G>T	uc002mkp.3	-	2	9864	c.9660C>A	c.(9658-9660)atC>atA	p.I3220I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.	3221	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTGGACCTGATCTCTGGGC	0.498000														74			61		1.53716e-24	1.72693e-24	0.048971	1	0
ARHGEF12	23365	broad.mit.edu	37	11	120352127	120352127	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr11:120352127G>T	uc001pxl.2	+	38	4731	c.4396G>T	c.(4396-4398)Gca>Tca	p.A1466S	ARHGEF12_uc009zat.3_Missense_Mutation_p.A1447S|ARHGEF12_uc009zau.1_Missense_Mutation_p.A1363S	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Homo sapiens Rho guanine nucleotide exchange factor (GEF) 12 (ARHGEF12), transcript variant 1, mRNA.	1466					G-protein coupled receptor protein signaling pathway|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CTCCGATGGGGCAATTTCACC	0.537000			T	MLL	AML									49			25		3.6726e-16	4.07569e-16	0.091800	1	0
HNF1B	6928	broad.mit.edu	37	17	36099582	36099582	+	Silent	SNP	T	C	C			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr17:36099582T>C	uc002hok.4	-	1	614	c.393A>G	c.(391-393)caA>caG	p.Q131Q	HNF1B_uc010wdi.2_Silent_p.Q131Q|HNF1B_uc021tvv.1_Silent_p.Q131Q|HNF1B_uc021tvw.1_Silent_p.Q131Q	NM_000458	NP_000449	P35680	HNF1B_HUMAN	Homo sapiens HNF1 homeobox B (HNF1B), transcript variant 1, mRNA.	131					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GGATGTTGTGTTGCTGCATGT	0.547000														23			39		0	0	0.086207	0	0
CROCCP2	84809	broad.mit.edu	37	1	16945460	16945460	+	RNA	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr1:16945460C>T	uc010ocf.2	-	3		c.697G>A			CROCCP2_uc009vov.2_Non-coding_Transcript|CROCCP2_uc001aze.3_Non-coding_Transcript|CROCCP2_uc001azf.3_Non-coding_Transcript					Homo sapiens ciliary rootlet coiled-coil, rootletin pseudogene 2 (CROCCP2), non-coding RNA.																		GACGGCAGGCCTACCCGGTCC	0.642000														155			10		0	0	0.069234	0	0
TMEM27	57393	broad.mit.edu	37	X	15682860	15682860	+	Silent	SNP	A	G	G			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chrX:15682860A>G	uc004cxc.2	-	0	295	c.39T>C	c.(37-39)caT>caC	p.H13H		NM_020665	NP_065716	Q9HBJ8	TMM27_HUMAN	Homo sapiens transmembrane protein 27 (TMEM27), mRNA.	13					proteolysis	integral to membrane	metallopeptidase activity|peptidyl-dipeptidase activity			endometrium(3)|lung(4)|ovary(1)	8	Hepatocellular(33;0.183)					AGAGTTCAGCATGAATGGCAG	0.373000														8			25		0	0	0.076483	0	0
CRYAA	1409	broad.mit.edu	37	21	44589374	44589374	+	Silent	SNP	C	G	G			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr21:44589374C>G	uc002zdd.1	+	0	234	c.165C>G	c.(163-165)acC>acG	p.T55T		NM_000394	NP_000385	P02489	CRYAA_HUMAN	Homo sapiens crystallin, alpha A (CRYAA), mRNA.	55					anti-apoptosis|negative regulation of intracellular transport|protein homooligomerization|response to heat|visual perception	cytoplasm|nucleus	structural constituent of eye lens|unfolded protein binding	p.R54C(1)|p.T55I(1)		NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	11						TCTTCCGCACCGTGCTGGACT	0.622000														69			74		0	0	0.048971	0	0
TREM2	54209	broad.mit.edu	37	6	41129014	41129014	+	Silent	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr6:41129014C>T	uc003opz.2	-	1	480	c.468G>A	c.(466-468)gtG>gtA	p.V156V	TREM2_uc003opy.2_Silent_p.V126V|TREM2_uc010jxl.1_Silent_p.V156V			Q9NZC2	TREM2_HUMAN	Homo sapiens triggering receptor expressed on myeloid cells 2 (TREM2), mRNA.	126					axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	11	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCAGCACCTCCACCAGGACCT	0.612000														24			13		0	0	0.093190	0	0
SNTA1	6640	broad.mit.edu	37	20	32026771	32026771	+	Silent	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr20:32026771G>A	uc002wzd.1	-	1	644	c.372C>T	c.(370-372)gaC>gaT	p.D124D	SNTA1_uc010zuf.1_Silent_p.D124D	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	Homo sapiens syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) (SNTA1), mRNA.	124	PDZ.|PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			breast(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|stomach(1)|urinary_tract(1)	13						CCTCTGTCTGGTCAGCTGCCA	0.527000														141			70		0	0	0.048971	0	0
ACPL2	92370	broad.mit.edu	37	3	140979087	140979087	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr3:140979087C>A	uc003etu.3	+	3	369	c.70C>A	c.(70-72)Ctg>Atg	p.L24M	ACPL2_uc003etv.3_Missense_Mutation_p.L24M|ACPL2_uc011bna.2_5'UTR|ACPL2_uc011bnb.2_5'Flank	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	Homo sapiens acid phosphatase-like 2 (ACPL2), transcript variant 1, mRNA.	24						extracellular region	acid phosphatase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(2)	23						GAGCCTCAGCCTGCAGTTCTG	0.517000														19			21		3.51602e-12	3.85491e-12	0.049695	1	0
DTX1	1840	broad.mit.edu	37	12	113534672	113534672	+	Silent	SNP	C	T	T	rs142267522	byFrequency	TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr12:113534672C>T	uc001tuk.1	+	8	2127	c.1791C>T	c.(1789-1791)gaC>gaT	p.D597D		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	Homo sapiens deltex homolog 1 (Drosophila) (DTX1), mRNA.	597					Notch signaling pathway|negative regulation of neuron differentiation|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding	p.D597D(2)		central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						GCTACCCGGACGCTAGCTACC	0.637000														42			3		0	0	0.009096	0	0
LOC100233156	100233156	broad.mit.edu	37	GL000218.1	40675	40675	+	Silent	SNP	G	A	A			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chrGL000218.1:40675G>A	uc011mfn.2	-	2	344	c.255C>T	c.(253-255)gaC>gaT	p.D85D	LOC100233156_uc003jah.2_Silent_p.D85D					Homo sapiens tektin 4 pseudogene (LOC100233156), transcript variant 1, non-coding RNA.																		TGTGCCGCACGTCCTCCAGTT	0.662000														9			3		0	0	0.004672	0	0
BCL9L	283149	broad.mit.edu	37	11	118771983	118771983	+	Silent	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr11:118771983C>T	uc001pug.3	-	5	3434	c.2469G>A	c.(2467-2469)caG>caA	p.Q823Q	BCL9L_uc009zal.3_Silent_p.Q818Q	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	Homo sapiens B-cell CLL/lymphoma 9-like (BCL9L), mRNA.	823	Met-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CACTGCTGTTCTGGGCCCGAA	0.652000														47			33		0	0	0.054565	0	0
SEC14L3	266629	broad.mit.edu	37	22	30866522	30866522	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr22:30866522A>T	uc003ahy.3	-	1	191	c.102T>A	c.(100-102)gaT>gaA	p.D34E	SEC14L3_uc003ahz.3_5'UTR|SEC14L3_uc003aia.3_5'UTR|SEC14L3_uc003aib.3_5'UTR	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	Homo sapiens SEC14-like 3 (S. cerevisiae) (SEC14L3), mRNA.	34						integral to membrane|intracellular	lipid binding|transporter activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	19					Vitamin E(DB00163)	GGAAATAATCATCAGGGTTGG	0.567000														27			25		0	0	0.099896	0	0
NARF	26502	broad.mit.edu	37	17	80443514	80443514	+	Silent	SNP	C	T	T			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr17:80443514C>T	uc010dit.3	+	11	1388	c.1248C>T	c.(1246-1248)gtC>gtT	p.V416V	NARF_uc002kff.4_Silent_p.V312V|NARF_uc002kfg.4_Silent_p.V371V|NARF_uc002kfj.4_Silent_p.V323V	NM_031968	NP_114174	Q9UHQ1	NARF_HUMAN	Homo sapiens nuclear prelamin A recognition factor (NARF), transcript variant 2, mRNA.	371						lamin filament	lamin binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			TTGTGGAGGTCCTCGCCTGTG	0.572000														27			77		0	0	0.048971	0	0
KIDINS220	57498	broad.mit.edu	37	2	8872073	8872073	+	Frame_Shift_Del	DEL	A	-	-			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr2:8872073delA	uc002qzc.2	-	29	4275	c.4093delT	c.(4093-4095)tccfs	p.S1365fs	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Frame_Shift_Del_p.S1266fs|KIDINS220_uc002qzb.2_Frame_Shift_Del_p.S219fs	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	Homo sapiens kinase D-interacting substrate, 220kDa (KIDINS220), mRNA.	1365					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GAATCCTGGGAATTGAGACTC	0.363													---	86	---	---	43	---					
ERC2	26059	broad.mit.edu	37	3	55733470	55733472	+	In_Frame_Del	DEL	TGG	-	-			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr3:55733470_55733472delTGG	uc021wzo.1	-	14	2921_2923	c.2781_2783delCCA	c.(2779-2784)caccat>cat	p.927_928HH>H	ERC2_uc003dhq.1_Non-coding_Transcript|ERC2_uc003dhr.1_In_Frame_Del_p.923_924HH>H	NM_015576	NP_056391	O15083	ERC2_HUMAN	Homo sapiens ELKS/RAB6-interacting/CAST family member 2 (ERC2), mRNA.	927	Poly-His.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		gtggtggtgatggtggtggtggt	0.502													---	369	---	---	8	---					
SH3BP2	6452	broad.mit.edu	37	4	2824661	2824661	+	Splice_Site	DEL	G	-	-			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr4:2824661delG	uc003gfi.4	+	3	257	c.137_splice	c.e3-1	p.W46_splice	SH3BP2_uc010icn.2_Splice_Site_p.W46_splice|SH3BP2_uc011bvp.2_Splice_Site_p.W74_splice|SH3BP2_uc003gfj.4_Splice_Site_p.W103_splice|SH3BP2_uc003gfk.4_Splice_Site_p.W46_splice|SH3BP2_uc003gfl.4_Splice_Site	NM_001122681	NP_003014	P78314	3BP2_HUMAN	Homo sapiens SH3-domain binding protein 2 (SH3BP2), transcript variant 2, mRNA.	46	PH.				signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		ACCTCCCACAGGGCCCCTGCG	0.622									Cherubism				---	18	---	---	13	---					
PCDH17	27253	broad.mit.edu	37	13	58208351	58208351	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr13:58208351delG	uc001vhq.1	+	0	2563	c.1671delG	c.(1669-1671)tcgfs	p.S557fs	PCDH17_uc010aec.1_Frame_Shift_Del_p.S557fs	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	Homo sapiens protocadherin 17 (PCDH17), mRNA.	557	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CTAAGGACTCGGGGGCGCCCG	0.592													---	73	---	---	21	---					
MTHFD1	4522	broad.mit.edu	37	14	64914978	64914979	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr14:64914978_64914979delAA	uc001xhb.3	+	22	2609_2610	c.2222_2223delAA	c.(2221-2223)caafs	p.Q741fs	MTHFD1_uc010aqf.3_Frame_Shift_Del_p.Q797fs	NM_005956	NP_005947	P11586	C1TC_HUMAN	Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (MTHFD1), mRNA.	741	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TTGAAGAAACAAATTGAAAATG	0.401													---	32	---	---	16	---					
ZNF263	10127	broad.mit.edu	37	16	3339974	3339974	+	Frame_Shift_Del	DEL	T	-	-			TCGA-A4-8311-01A-11D-2396-08	TCGA-A4-8311-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed5c8ff4-0d94-443d-9024-efdae20db5f3	ffccfd57-43fd-497f-b78d-a644b37173b2	g.chr16:3339974delT	uc002cuq.3	+	5	1800	c.1468delT	c.(1468-1470)tacfs	p.Y490fs	ZNF263_uc010uww.2_Frame_Shift_Del_p.Y138fs|ZNF263_uc002cur.2_Frame_Shift_Del_p.Y138fs	NM_005741	NP_005732	O14978	ZN263_HUMAN	Homo sapiens zinc finger protein 263 (ZNF263), mRNA.	490					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(4)|urinary_tract(3)	20						GGAGAAGCCCTACAAGTGCCC	0.537													---	49	---	---	19	---					
