Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CACNA1C	775	broad.mit.edu	37	12	2614092	2614092	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr12:2614092G>T	uc009zdu.1	+	7	1511	c.1198G>T	c.(1198-1200)Gtt>Ttt	p.V400F	CACNA1C_uc001qkc.2_Missense_Mutation_p.V400F|CACNA1C_uc001qjz.2_Missense_Mutation_p.V400F|CACNA1C_uc001qkd.2_Missense_Mutation_p.V400F|CACNA1C_uc001qke.2_Missense_Mutation_p.V400F|CACNA1C_uc001qkf.2_Missense_Mutation_p.V400F|CACNA1C_uc009zdw.1_Missense_Mutation_p.V400F|CACNA1C_uc001qkg.2_Missense_Mutation_p.V400F|CACNA1C_uc001qkh.2_Missense_Mutation_p.V400F|CACNA1C_uc001qkl.2_Missense_Mutation_p.V400F|CACNA1C_uc001qkj.2_Intron|CACNA1C_uc001qkk.2_Intron|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qkm.2_Intron|CACNA1C_uc001qko.2_Missense_Mutation_p.V400F|CACNA1C_uc001qkp.2_Missense_Mutation_p.V400F|CACNA1C_uc001qkq.2_Missense_Mutation_p.V400F|CACNA1C_uc001qku.2_Missense_Mutation_p.V400F|CACNA1C_uc001qkr.2_Missense_Mutation_p.V400F|CACNA1C_uc001qks.2_Missense_Mutation_p.V400F|CACNA1C_uc001qkt.2_Missense_Mutation_p.V400F|CACNA1C_uc009zdv.1_Missense_Mutation_p.V397F|CACNA1C_uc001qkb.2_Missense_Mutation_p.V400F|CACNA1C_uc001qka.1_Intron|CACNA1C_uc001qki.1_Intron|CACNA1C_uc009zdy.1_Intron|CACNA1C_uc001qkv.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	Homo sapiens calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C), transcript variant 1, mRNA.	400					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACTTAACTTGGTTCTCGGTGT	0.398000														10			6		0.00116845	0.00124634	0.021553	1	0
MST1P2	11209	broad.mit.edu	37	1	16974224	16974224	+	RNA	SNP	C	G	G	rs148702086	by1000genomes	TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr1:16974224C>G	uc009vow.2	+	4		c.1034C>G			MST1P2_uc010ocg.1_Non-coding_Transcript|MST1P2_uc010och.2_Intron|MST1P2_uc010oci.1_Non-coding_Transcript|MST1P2_uc001azk.2_Intron|MST1P2_uc009vox.3_Intron|MST1P2_uc001azm.4_Intron					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 2 (MST1P2), non-coding RNA.																		TTGGTCCCAGCCCCAGAGGGA	0.652000														22			3		0	0	0.014758	0	0
ATP10A	57194	broad.mit.edu	37	15	25972305	25972305	+	Splice_Site	SNP	A	T	T			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr15:25972305A>T	uc010ayu.3	-	4	953	c.847_splice	c.e4+1	p.G283_splice		NM_024490	NP_077816	O60312	AT10A_HUMAN	Homo sapiens ATPase, class V, type 10A (ATP10A), mRNA.	283					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCCCGAGCCTACCTGCGTAGA	0.517000														41			31		0	0	0.008361	0	0
DUSP27	92235	broad.mit.edu	37	1	167097085	167097085	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr1:167097085A>C	uc001geb.1	+	4	2733	c.2717A>C	c.(2716-2718)aAa>aCa	p.K906T		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	Homo sapiens dual specificity phosphatase 27 (putative) (DUSP27), mRNA.	906	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AATTCCCAGAAACCTGAAACA	0.493000														41			5		0	0	0.014758	0	0
LYZL6	57151	broad.mit.edu	37	17	34261844	34261844	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr17:34261844C>T	uc002hkj.2	-	3	603	c.403G>A	c.(403-405)Ggc>Agc	p.G135S	LYZL6_uc002hkk.2_Missense_Mutation_p.G135S	NM_020426	NP_065159	O75951	LYZL6_HUMAN	Homo sapiens lysozyme-like 6 (LYZL6), transcript variant 2, mRNA.	135					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			breast(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	12				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTGGCCGGCCTGAACAGTGC	0.542000														46			16		0	0	0.004990	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217279802	217279802	+	Silent	SNP	C	G	G			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr2:217279802C>G	uc002vgc.4	+	2	705	c.375C>G	c.(373-375)ccC>ccG	p.P125P	SMARCAL1_uc002vgd.4_Silent_p.P125P|SMARCAL1_uc010fvg.3_Silent_p.P125P	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (SMARCAL1), transcript variant 1, mRNA.	125					DNA metabolic process|chromatin modification|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		TCTCTCCTCCCTTGGCACAAA	0.507000									Schimke Immuno-Osseous Dysplasia					59			40		0	0	0.027894	0	0
X97876	0	broad.mit.edu	37	9	66499680	66499680	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr9:66499680C>A	uc004aee.1	+	0	490	c.490C>A	c.(490-492)Ccc>Acc	p.P164T	X97876_uc004aed.1_Non-coding_Transcript					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).																		TCATGTTAACCCCTTCCCAGG	0.582000														54			6		2.0095e-06	2.29657e-06	0.001984	1	0
AK308867	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr16:70268158A>C	uc010cfp.1	-	2		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333000														10			3		0	0	0.004672	0	0
ATP2A3	489	broad.mit.edu	37	17	3844534	3844534	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr17:3844534T>C	uc002fwy.2	-	13	2004	c.1831A>G	c.(1831-1833)Atc>Gtc	p.I611V	ATP2A3_uc002fwz.2_Missense_Mutation_p.I611V|ATP2A3_uc002fxa.2_Missense_Mutation_p.I611V|ATP2A3_uc002fxb.2_Missense_Mutation_p.I611V|ATP2A3_uc002fxc.2_Missense_Mutation_p.I611V|ATP2A3_uc002fxd.2_Missense_Mutation_p.I611V|ATP2A3_uc002fwx.2_Missense_Mutation_p.I611V	NM_174953	NP_777613	Q93084	AT2A3_HUMAN	Homo sapiens ATPase, Ca++ transporting, ubiquitous (ATP2A3), transcript variant 5, mRNA.	611					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding	p.I611M(1)		breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CAGCGTGTGATGCAGGCAGCC	0.647000														100			6		0	0	0.001984	0	0
TRIP11	9321	broad.mit.edu	37	14	92470654	92470654	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr14:92470654T>A	uc001xzy.3	-	10	4040	c.3666A>T	c.(3664-3666)gaA>gaT	p.E1222D	TRIP11_uc010auf.2_Missense_Mutation_p.E958D	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	Homo sapiens thyroid hormone receptor interactor 11 (TRIP11), mRNA.	1222					transcription from RNA polymerase II promoter	Golgi apparatus|cytoskeleton|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		GCTTCCACTCTTCCATTTTCT	0.443000			T	PDGFRB	AML									33			28		0	0	0.024334	0	0
MTUS2	23281	broad.mit.edu	37	13	29599704	29599704	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr13:29599704C>T	uc001usl.4	+	0	957	c.899C>T	c.(898-900)tCg>tTg	p.S300L		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	Homo sapiens microtubule associated tumor suppressor candidate 2 (MTUS2), transcript variant 1, mRNA.	290						cytoplasm|microtubule	microtubule binding|protein homodimerization activity	p.S300L(2)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						ACTTTGGCATCGAAGGAAATC	0.507000														21			9		0	0	0.004482	0	0
FBXW2	26190	broad.mit.edu	37	9	123527053	123527053	+	Silent	SNP	G	A	A			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr9:123527053G>A	uc004bkn.2	-	7	1572	c.1245C>T	c.(1243-1245)gaC>gaT	p.D415D	FBXW2_uc011lyc.1_Silent_p.D254D|FBXW2_uc004bkl.1_Silent_p.D383D|FBXW2_uc004bkm.1_Silent_p.D383D|FBXW2_uc010mvj.1_Silent_p.D318D	NM_012164	NP_036296	Q9UKT8	FBXW2_HUMAN	Homo sapiens F-box and WD repeat domain containing 2 (FBXW2), mRNA.	383					proteolysis		protein binding|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	4						GGTAGCGGTTGTCAAACAGCA	0.502000														106			10		0	0	0.008291	0	0
SLC8A3	6547	broad.mit.edu	37	14	70527578	70527578	+	Silent	SNP	C	T	T			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr14:70527578C>T	uc001xly.3	-	2	2617	c.1863G>A	c.(1861-1863)ccG>ccA	p.P621P	SLC8A3_uc001xlv.3_5'UTR|SLC8A3_uc001xlu.3_Intron|SLC8A3_uc001xlw.3_Silent_p.P621P|SLC8A3_uc001xlx.3_Intron|SLC8A3_uc001xlz.3_Silent_p.P621P|SLC8A3_uc010ara.3_Intron|SLC8A3_uc001xma.2_Intron	NM_183002	NP_892114	P57103	NAC3_HUMAN	Homo sapiens solute carrier family 8 (sodium/calcium exchanger), member 3 (SLC8A3), transcript variant c, mRNA.	621					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CCATCCATTTCGGTTCACCAA	0.343000														41			20		0	0	0.008871	0	0
SRCAP	10847	broad.mit.edu	37	16	30718524	30718524	+	Silent	SNP	G	T	T			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr16:30718524G>T	uc002dze.1	+	4	712	c.327G>T	c.(325-327)cgG>cgT	p.R109R	SRCAP_uc021tgn.1_Silent_p.R109R|SRCAP_uc002dzf.3_Non-coding_Transcript|SRCAP_uc002dzg.1_5'UTR	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Homo sapiens Snf2-related CREBBP activator protein (SRCAP), mRNA.	109					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TCGAGACTCGGATTGCTGAGC	0.547000														48			30		1.74807e-11	2.07179e-11	0.010818	1	0
PPIL1	51645	broad.mit.edu	37	6	36842542	36842542	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr6:36842542C>T	uc003omu.2	-	0	259	c.7G>A	c.(7-9)Gca>Aca	p.A3T	C6orf89_uc003omv.3_Intron	NM_016059	NP_057143	Q9Y3C6	PPIL1_HUMAN	Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 1 (PPIL1), mRNA.	3					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity	p.A3V(1)		lung(1)|ovary(1)	2						GGGGGAATTGCCGCCATAGCG	0.637000														21			3		0	0	0.004672	0	0
AMBP	259	broad.mit.edu	37	9	116840419	116840419	+	Missense_Mutation	SNP	G	A	A	rs142189555	byFrequency	TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr9:116840419G>A	uc004bie.4	-	0	334	c.71C>T	c.(70-72)aCg>aTg	p.T24M	AMBP_uc011lxk.2_5'Flank|AMBP_uc010mvc.1_Non-coding_Transcript	NM_001633	NP_001624	P02760	AMBP_HUMAN	Homo sapiens alpha-1-microglobulin/bikunin precursor (AMBP), mRNA.	24					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of JNK cascade|negative regulation of immune response|protein-chromophore linkage	extracellular region|plasma membrane	IgA binding|calcium channel inhibitor activity|calcium oxalate binding|heme binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	11					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	GTCGGGCGGCGTTGGCACAGG	0.617000														72			49		0	0	0.014410	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48600413	48600413	+	Silent	SNP	A	T	T			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr17:48600413A>T	uc010wmr.2	+	10	1662	c.1500A>T	c.(1498-1500)cgA>cgT	p.R500R	MYCBPAP_uc002iqz.3_Non-coding_Transcript	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Homo sapiens MYCBP associated protein (MYCBPAP), mRNA.	463					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding	p.T500A(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			ATGACTGGCGACGGCAGCACC	0.507000														78			48		0	0	0.014410	0	0
MMP13	4322	broad.mit.edu	37	11	102826393	102826393	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr11:102826393C>A	uc001phl.3	-	0	71	c.42G>T	c.(40-42)tgG>tgT	p.W14C		NM_002427	NP_002418	P45452	MMP13_HUMAN	Homo sapiens matrix metallopeptidase 13 (collagenase 3) (MMP13), mRNA.	14					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GACAATGAGTCCAGCTCAAGA	0.507000														84			9		0.000442599	0.000488386	0.006214	1	0
CROCCP2	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	T	T	rs367060		TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr1:16946434C>T	uc010ocf.2	-	2		c.464G>A			CROCCP2_uc009vov.2_Non-coding_Transcript|CROCCP2_uc001aze.3_Non-coding_Transcript|CROCCP2_uc001azf.3_Non-coding_Transcript					Homo sapiens ciliary rootlet coiled-coil, rootletin pseudogene 2 (CROCCP2), non-coding RNA.																		CTCAGCCTTCCGCCGGGCCAG	0.672000														27			5		0	0	0.014758	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	T	T	rs121913529		TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr12:25398284C>T	uc001rgp.1	-	1	216	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.3_Non-coding_Transcript|DD157417_uc021qwd.1_Non-coding_Transcript	NM_033360	NP_203524	P01116	RASK_HUMAN	Homo sapiens v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), transcript variant a, mRNA.	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(17126)|p.G12V(11533)|p.G12C(2976)|p.G12A(2808)|p.G12S(1288)|p.G12R(790)|p.G12F(96)|p.G12?(57)|p.G12L(17)|p.G12G(9)|p.G12I(8)|p.G12N(7)|p.G12W(7)|p.G12E(6)|p.G10_A11insG(5)|p.G12_G13insG(4)|p.G12Y(4)|p.A11V(3)|p.A11P(2)|p.A11_G12insGA(2)|p.G12fs*3(2)|p.A11A(1)|p.G12_G13insA(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)				15			14		0	0	0.006122	0	0
BICD1	636	broad.mit.edu	37	12	32491723	32491724	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr12:32491723_32491724delAT	uc001rku.3	+	7	2655_2656	c.2574_2575delAT	c.(2572-2577)caatttfs	p.Q858fs	BICD1_uc001rkv.3_Intron|BICD1_uc010skd.2_Non-coding_Transcript	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	Homo sapiens bicaudal D homolog 1 (Drosophila) (BICD1), transcript variant 1, mRNA.	858					RNA processing|anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	Rab GTPase binding|cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CTGCAAGACAATTTTCACCTTC	0.406													---	124	---	---	62	---					
LOC100132247	100132247	broad.mit.edu	37	16	22545578	22545580	+	In_Frame_Del	DEL	ATA	-	-			TCGA-A4-8312-01A-11D-2396-08	TCGA-A4-8312-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f9961fbe-ca3b-4c52-b923-82430aef5a16	16e755f0-8784-4438-a9e3-0bc481bbaf86	g.chr16:22545578_22545580delATA	uc010bxg.3	+	8	1456_1458	c.1274_1276delATA	c.(1273-1278)gataat>gat	p.N426del	LOC100132247_uc010vbv.2_In_Frame_Del_p.N426del|LOC100132247_uc021tew.1_In_Frame_Del_p.N426del|LOC100132247_uc010bxi.3_In_Frame_Del_p.N407del|LOC100132247_uc010bxk.3_In_Frame_Del_p.N243del	NM_001135865	NP_001129337			Homo sapiens nuclear pore complex interacting protein related gene (LOC100132247), mRNA.																		TCAGCGGATGATAATCTCAAGAC	0.586													---	5	---	---	3	---					
