Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KCNH8	131096	broad.mit.edu	37	3	19389246	19389246	+	Silent	SNP	G	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr3:19389246G>A	uc003cbk.1	+	4	795	c.600G>A	c.(598-600)ccG>ccA	p.P200P	KCNH8_uc011awe.1_Silent_p.P200P|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 8 (KCNH8), mRNA.	200						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						CAGCATTTCCGGAGTATAAAG	0.358000														102			7		0	0	0.001984	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910735	230910735	+	Silent	SNP	G	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr2:230910735G>A	uc002vqd.2	-	3	1566	c.1107C>T	c.(1105-1107)atC>atT	p.I369I	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.3_Silent_p.I369I|SLC16A14_uc002vqf.3_Silent_p.I369I	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	Homo sapiens solute carrier family 16, member 14 (monocarboxylic acid transporter 14) (SLC16A14), mRNA.	369						integral to membrane|plasma membrane	symporter activity	p.I369I(2)		NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TGACGCCCAGGATCACTTTTC	0.433000														69			19		0	0	0.008871	0	0
AP2A1	160	broad.mit.edu	37	19	50305818	50305818	+	Silent	SNP	C	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr19:50305818C>T	uc002ppn.3	+	15	2353	c.2142C>T	c.(2140-2142)agC>agT	p.S714S	AP2A1_uc010enj.1_Intron|AP2A1_uc002ppo.3_Intron|AP2A1_uc002ppp.1_Missense_Mutation_p.P216S|AP2A1_uc010enk.3_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	Homo sapiens adaptor-related protein complex 2, alpha 1 subunit (AP2A1), transcript variant 1, mRNA.	714					Golgi to endosome transport|axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)	19		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		CCCCCGAGAGCCCCATGGCTT	0.667000														14			3		0	0	0.004672	0	0
KCNK5	8645	broad.mit.edu	37	6	39161945	39161945	+	Splice_Site	SNP	C	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr6:39161945C>T	uc003oon.3	-	4	998	c.634_splice	c.e4+1	p.G212_splice		NM_003740	NP_003731	O95279	KCNK5_HUMAN	Homo sapiens potassium channel, subfamily K, member 5 (KCNK5), mRNA.	212					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						AGGGACTCACCGGCCACAAAG	0.542000														52			19		0	0	0.007413	0	0
HSD11B1	3290	broad.mit.edu	37	1	209878262	209878262	+	Splice_Site	SNP	G	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr1:209878262G>A	uc001hhj.3	+	2	107	c.-25_splice	c.e2-1		HSD11B1_uc021pin.1_5'UTR|HSD11B1_uc001hhk.3_5'UTR	NM_181755	NP_861420	P28845	DHI1_HUMAN	Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 2, mRNA.						glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase|11-beta-hydroxysteroid dehydrogenase (NADP+) activity|binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	16				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	TGTCCTACAGGAGTCTTCAGG	0.512000														26			11		0	0	0.008291	0	0
KCNC4	3749	broad.mit.edu	37	1	110774916	110774916	+	Silent	SNP	G	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr1:110774916G>A	uc001dzh.3	+	3	2679	c.1893G>A	c.(1891-1893)ctG>ctA	p.L631L	KCNC4_uc001dzi.3_Non-coding_Transcript|KCNC4_uc001dzg.3_Intron	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Homo sapiens potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), transcript variant 1, mRNA.	631					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTGGGACTCTGTTCCTGCCAC	0.562000														20			9		0	0	0.006214	0	0
PREX2	80243	broad.mit.edu	37	8	68995502	68995502	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr8:68995502A>T	uc003xxv.1	+	17	1933	c.1906A>T	c.(1906-1908)Att>Ttt	p.I636F	PREX2_uc003xxu.1_Missense_Mutation_p.I636F|PREX2_uc011lez.1_Missense_Mutation_p.I571F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2), transcript variant 1, mRNA.	636	PDZ 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity|protein binding			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CGGGAAAAAGATTTTTGCTAT	0.318000														66			5		0	0	0.001168	0	0
LINGO4	339398	broad.mit.edu	37	1	151774638	151774638	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr1:151774638C>G	uc001ezf.1	-	1	733	c.543G>C	c.(541-543)aaG>aaC	p.K181N	LINGO4_uc021oyu.1_Missense_Mutation_p.K181N	NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	Homo sapiens leucine rich repeat and Ig domain containing 4 (LINGO4), mRNA.	181						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGGTGCTCAACTTGGCTAGCC	0.612000														84			6		0	0	0.001168	0	0
TDRD6	221400	broad.mit.edu	37	6	46658247	46658247	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr6:46658247C>G	uc003oyj.3	+	0	2636	c.2382C>G	c.(2380-2382)aaC>aaG	p.N794K	TDRD6_uc010jze.3_Missense_Mutation_p.N794K	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	Homo sapiens tudor domain containing 6 (TDRD6), transcript variant 1, mRNA.	794					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TGACCAGGAACATACAAGGAC	0.428000														64			10		0	0	0.006214	0	0
POTEC	388468	broad.mit.edu	37	18	14533088	14533088	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr18:14533088C>T	uc010dln.3	-	4	1481	c.1027G>A	c.(1027-1029)Gag>Aag	p.E343K	POTEC_uc010xaj.2_Non-coding_Transcript	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	Homo sapiens POTE ankyrin domain family, member C (POTEC), mRNA.	343										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						ACAGCATACTCTCTGGCCGTC	0.353000														129			33		0	0	0.013114	0	0
BC063132	0	broad.mit.edu	37	GL000241.1	34494	34494	+	Splice_Site	SNP	C	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chrGL000241.1:34494C>T	uc011mgv.2	-	3		c.389_splice	c.e3+1							Homo sapiens cDNA clone IMAGE:4673444, containing frame-shift errors.																		AACTGACTCACCAACATATCA	0.279000														77			6		0	0	0.001168	0	0
MRVI1	10335	broad.mit.edu	37	11	10626061	10626061	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr11:10626061C>G	uc010rcc.1	-	12	2020	c.1634G>C	c.(1633-1635)aGa>aCa	p.R545T	MRVI1_uc010rcb.1_Missense_Mutation_p.R537T|MRVI1_uc001miw.2_Missense_Mutation_p.R536T|MRVI1_uc001mix.3_Missense_Mutation_p.R230T|MRVI1_uc001miz.2_Missense_Mutation_p.R454T|MRVI1_uc010rcd.1_Missense_Mutation_p.R339T|MRVI1_uc009ygd.1_Missense_Mutation_p.R230T|MRVI1_uc010rce.1_Non-coding_Transcript	NM_130385	NP_569056	Q9Y6F6	MRVI1_HUMAN	Homo sapiens murine retrovirus integration site 1 homolog (MRVI1), transcript variant 2, mRNA.	518	Interaction with ITPR1 (By similarity).				platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		GCTGTCATTTCTAAAGGCCAA	0.488000														61			18		0	0	0.004990	0	0
ANAPC7	51434	broad.mit.edu	37	12	110813921	110813921	+	Silent	SNP	T	C	C			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr12:110813921T>C	uc001tqo.2	-	9	1561	c.1560A>G	c.(1558-1560)gtA>gtG	p.V520V	ANAPC7_uc001tqp.4_Silent_p.V520V	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	Homo sapiens anaphase promoting complex subunit 7 (ANAPC7), transcript variant 1, mRNA.	520					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)	19						CATTGACAGCTACAAGGAAAT	0.498000														54			13		0	0	0.016723	0	0
SPDYE7P	441251	broad.mit.edu	37	7	72339511	72339511	+	RNA	SNP	A	C	C			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr7:72339511A>C	uc010lal.1	-	0		c.145T>G								Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.																		CCACCACTCCATCTTCCTTTT	0.582000														39			5		0	0	0.001168	0	0
BAGE1	0	broad.mit.edu	37	GL000237.1	2577	2577	+	RNA	SNP	C	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chrGL000237.1:2577C>T	uc011mgu.1	-	0		c.110G>A								Homo sapiens B melanoma antigen variant f (BAGE1) mRNA, complete cds, alternatively spliced.																		ccatccagagcgagacgagcc	0.627000														11			3		0	0	0.014758	0	0
LMLN	89782	broad.mit.edu	37	3	197687183	197687183	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr3:197687183T>A	uc010iar.3	+	0	113	c.91T>A	c.(91-93)Tgg>Agg	p.W31R	IQCG_uc003fyp.3_5'Flank|LMLN_uc003fyt.3_Missense_Mutation_p.L19Q|LMLN_uc011buo.2_Missense_Mutation_p.W31R|LMLN_uc010ias.3_Missense_Mutation_p.L19Q|LMLN_uc003fyu.3_5'UTR	NM_001136049	NP_001129521	Q96KR4	LMLN_HUMAN	Homo sapiens leishmanolysin-like (metallopeptidase M8 family) (LMLN), transcript variant 1, mRNA.	31					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CCGGTGGCGCTGGAGCGGGTC	0.687000														70			17		0	0	0.004990	0	0
NAB2	4665	broad.mit.edu	37	12	57485439	57485439	+	Silent	SNP	G	C	C			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr12:57485439G>C	uc001smz.3	+	1	993	c.615G>C	c.(613-615)tcG>tcC	p.S205S		NM_005967	NP_005958	Q15742	NAB2_HUMAN	Homo sapiens NGFI-A binding protein 2 (EGR1 binding protein 2) (NAB2), mRNA.	205					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						AGGCTGGCTCGCCCCCCTTCT	0.726000														31			8		0	0	0.006214	0	0
KCNH8	131096	broad.mit.edu	37	3	19389246	19389246	+	Silent	SNP	G	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr3:19389246G>A	uc003cbk.1	+	4	795	c.600G>A	c.(598-600)ccG>ccA	p.P200P	KCNH8_uc011awe.1_Silent_p.P200P|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 8 (KCNH8), mRNA.	200						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						CAGCATTTCCGGAGTATAAAG	0.358000														102			7		0	0	0.001984	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910735	230910735	+	Silent	SNP	G	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr2:230910735G>A	uc002vqd.2	-	3	1566	c.1107C>T	c.(1105-1107)atC>atT	p.I369I	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.3_Silent_p.I369I|SLC16A14_uc002vqf.3_Silent_p.I369I	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	Homo sapiens solute carrier family 16, member 14 (monocarboxylic acid transporter 14) (SLC16A14), mRNA.	369						integral to membrane|plasma membrane	symporter activity	p.I369I(2)		NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TGACGCCCAGGATCACTTTTC	0.433000														69			19		0	0	0.008871	0	0
AP2A1	160	broad.mit.edu	37	19	50305818	50305818	+	Silent	SNP	C	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr19:50305818C>T	uc002ppn.3	+	15	2353	c.2142C>T	c.(2140-2142)agC>agT	p.S714S	AP2A1_uc010enj.1_Intron|AP2A1_uc002ppo.3_Intron|AP2A1_uc002ppp.1_Missense_Mutation_p.P216S|AP2A1_uc010enk.3_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	Homo sapiens adaptor-related protein complex 2, alpha 1 subunit (AP2A1), transcript variant 1, mRNA.	714					Golgi to endosome transport|axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)	19		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		CCCCCGAGAGCCCCATGGCTT	0.667000														14			3		0	0	0.004672	0	0
KCNK5	8645	broad.mit.edu	37	6	39161945	39161945	+	Splice_Site	SNP	C	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr6:39161945C>T	uc003oon.3	-	4	998	c.634_splice	c.e4+1	p.G212_splice		NM_003740	NP_003731	O95279	KCNK5_HUMAN	Homo sapiens potassium channel, subfamily K, member 5 (KCNK5), mRNA.	212					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						AGGGACTCACCGGCCACAAAG	0.542000														52			19		0	0	0.007413	0	0
HSD11B1	3290	broad.mit.edu	37	1	209878262	209878262	+	Splice_Site	SNP	G	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr1:209878262G>A	uc001hhj.3	+	2	107	c.-25_splice	c.e2-1		HSD11B1_uc021pin.1_5'UTR|HSD11B1_uc001hhk.3_5'UTR	NM_181755	NP_861420	P28845	DHI1_HUMAN	Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 2, mRNA.						glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase|11-beta-hydroxysteroid dehydrogenase (NADP+) activity|binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	16				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	TGTCCTACAGGAGTCTTCAGG	0.512000														26			11		0	0	0.008291	0	0
KCNC4	3749	broad.mit.edu	37	1	110774916	110774916	+	Silent	SNP	G	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr1:110774916G>A	uc001dzh.3	+	3	2679	c.1893G>A	c.(1891-1893)ctG>ctA	p.L631L	KCNC4_uc001dzi.3_Non-coding_Transcript|KCNC4_uc001dzg.3_Intron	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Homo sapiens potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), transcript variant 1, mRNA.	631					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTGGGACTCTGTTCCTGCCAC	0.562000														20			9		0	0	0.006214	0	0
PREX2	80243	broad.mit.edu	37	8	68995502	68995502	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr8:68995502A>T	uc003xxv.1	+	17	1933	c.1906A>T	c.(1906-1908)Att>Ttt	p.I636F	PREX2_uc003xxu.1_Missense_Mutation_p.I636F|PREX2_uc011lez.1_Missense_Mutation_p.I571F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2), transcript variant 1, mRNA.	636	PDZ 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity|protein binding			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CGGGAAAAAGATTTTTGCTAT	0.318000														66			5		0	0	0.001168	0	0
LINGO4	339398	broad.mit.edu	37	1	151774638	151774638	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr1:151774638C>G	uc001ezf.1	-	1	733	c.543G>C	c.(541-543)aaG>aaC	p.K181N	LINGO4_uc021oyu.1_Missense_Mutation_p.K181N	NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	Homo sapiens leucine rich repeat and Ig domain containing 4 (LINGO4), mRNA.	181						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGGTGCTCAACTTGGCTAGCC	0.612000														84			6		0	0	0.001168	0	0
TDRD6	221400	broad.mit.edu	37	6	46658247	46658247	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr6:46658247C>G	uc003oyj.3	+	0	2636	c.2382C>G	c.(2380-2382)aaC>aaG	p.N794K	TDRD6_uc010jze.3_Missense_Mutation_p.N794K	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	Homo sapiens tudor domain containing 6 (TDRD6), transcript variant 1, mRNA.	794					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TGACCAGGAACATACAAGGAC	0.428000														64			10		0	0	0.006214	0	0
POTEC	388468	broad.mit.edu	37	18	14533088	14533088	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr18:14533088C>T	uc010dln.3	-	4	1481	c.1027G>A	c.(1027-1029)Gag>Aag	p.E343K	POTEC_uc010xaj.2_Non-coding_Transcript	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	Homo sapiens POTE ankyrin domain family, member C (POTEC), mRNA.	343										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						ACAGCATACTCTCTGGCCGTC	0.353000														129			33		0	0	0.013114	0	0
BC063132	0	broad.mit.edu	37	GL000241.1	34494	34494	+	Splice_Site	SNP	C	T	T			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chrGL000241.1:34494C>T	uc011mgv.2	-	3		c.389_splice	c.e3+1							Homo sapiens cDNA clone IMAGE:4673444, containing frame-shift errors.																		AACTGACTCACCAACATATCA	0.279000														77			6		0	0	0.001168	0	0
MRVI1	10335	broad.mit.edu	37	11	10626061	10626061	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr11:10626061C>G	uc010rcc.1	-	12	2020	c.1634G>C	c.(1633-1635)aGa>aCa	p.R545T	MRVI1_uc010rcb.1_Missense_Mutation_p.R537T|MRVI1_uc001miw.2_Missense_Mutation_p.R536T|MRVI1_uc001mix.3_Missense_Mutation_p.R230T|MRVI1_uc001miz.2_Missense_Mutation_p.R454T|MRVI1_uc010rcd.1_Missense_Mutation_p.R339T|MRVI1_uc009ygd.1_Missense_Mutation_p.R230T|MRVI1_uc010rce.1_Non-coding_Transcript	NM_130385	NP_569056	Q9Y6F6	MRVI1_HUMAN	Homo sapiens murine retrovirus integration site 1 homolog (MRVI1), transcript variant 2, mRNA.	518	Interaction with ITPR1 (By similarity).				platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		GCTGTCATTTCTAAAGGCCAA	0.488000														61			18		0	0	0.004990	0	0
ANAPC7	51434	broad.mit.edu	37	12	110813921	110813921	+	Silent	SNP	T	C	C			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr12:110813921T>C	uc001tqo.2	-	9	1561	c.1560A>G	c.(1558-1560)gtA>gtG	p.V520V	ANAPC7_uc001tqp.4_Silent_p.V520V	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	Homo sapiens anaphase promoting complex subunit 7 (ANAPC7), transcript variant 1, mRNA.	520					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)	19						CATTGACAGCTACAAGGAAAT	0.498000														54			13		0	0	0.016723	0	0
LMLN	89782	broad.mit.edu	37	3	197687183	197687183	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr3:197687183T>A	uc010iar.3	+	0	113	c.91T>A	c.(91-93)Tgg>Agg	p.W31R	IQCG_uc003fyp.3_5'Flank|LMLN_uc003fyt.3_Missense_Mutation_p.L19Q|LMLN_uc011buo.2_Missense_Mutation_p.W31R|LMLN_uc010ias.3_Missense_Mutation_p.L19Q|LMLN_uc003fyu.3_5'UTR	NM_001136049	NP_001129521	Q96KR4	LMLN_HUMAN	Homo sapiens leishmanolysin-like (metallopeptidase M8 family) (LMLN), transcript variant 1, mRNA.	31					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CCGGTGGCGCTGGAGCGGGTC	0.687000														70			17		0	0	0.004990	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274020	39274020	+	Missense_Mutation	SNP	C	G	G	rs80129796	by1000genomes	TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr17:39274020C>G	uc002hvz.3	-	0	587	c.548G>C	c.(547-549)aGc>aCc	p.S183T		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	Homo sapiens keratin associated protein 4-11 (KRTAP4-11), mRNA.	183						keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCGGGGGCAGCTGGAGATGAC	0.622000														9			2		0	0	0.004672	0	0
LOC729862	729862	broad.mit.edu	37	5	28927163	28927163	+	RNA	SNP	A	G	G	rs486473	by1000genomes	TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr5:28927163A>G	uc003jgz.1	+	0		c.187A>G								Homo sapiens striatin, calmodulin binding protein pseudogene (LOC729862), non-coding RNA.																		ACAGGGAGAAAGGAAGGGCCA	0.453000														34			3		0	0	0.009096	0	0
NAB2	4665	broad.mit.edu	37	12	57485439	57485439	+	Silent	SNP	G	C	C			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr12:57485439G>C	uc001smz.3	+	1	993	c.615G>C	c.(613-615)tcG>tcC	p.S205S		NM_005967	NP_005958	Q15742	NAB2_HUMAN	Homo sapiens NGFI-A binding protein 2 (EGR1 binding protein 2) (NAB2), mRNA.	205					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						AGGCTGGCTCGCCCCCCTTCT	0.726000														31			8		0	0	0.006214	0	0
USP19	10869	broad.mit.edu	37	3	49148785	49148785	+	Frame_Shift_Del	DEL	C	-	-			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr3:49148785delC	uc003cwd.2	-	20	3241	c.2922delG	c.(2920-2922)gggfs	p.G974fs	USP19_uc003cwa.3_Frame_Shift_Del_p.G782fs|USP19_uc003cwb.3_Intron|USP19_uc003cvz.4_Frame_Shift_Del_p.G1077fs|USP19_uc011bcg.2_Frame_Shift_Del_p.G1065fs|USP19_uc003cwc.2_Frame_Shift_Del_p.G732fs|USP19_uc011bch.2_Frame_Shift_Del_p.G1075fs	NM_006677	NP_006668	O94966	UBP19_HUMAN	Homo sapiens ubiquitin specific peptidase 19 (USP19), transcript variant 4, mRNA.	974					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GATGCTGGTACCCAGGCACAG	0.532													---	87	---	---	20	---					
SMAP1	60682	broad.mit.edu	37	6	71508370	71508370	+	Frame_Shift_Del	DEL	A	-	-			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr6:71508370delA	uc003pfr.3	+	5	754	c.506delA	c.(505-507)gaafs	p.E169fs	SMAP1_uc011dxy.1_Non-coding_Transcript|SMAP1_uc003pfs.3_Frame_Shift_Del_p.E142fs|SMAP1_uc010kao.3_Frame_Shift_Del_p.E142fs|SMAP1_uc010kap.3_Frame_Shift_Del_p.E159fs	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	Homo sapiens small ArfGAP 1 (SMAP1), transcript variant 1, mRNA.	169					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding	p.K145fs*48(1)		breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(1)	15						aaagaaaaggaaaaaaaaaag	0.289													---	5	---	---	4	---					
ZNF367	195828	broad.mit.edu	37	9	99180258	99180259	+	In_Frame_Ins	INS	-	GGC	GGC			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	b2d31124-b2e7-4487-864e-be8baf0a8289	g.chr9:99180258_99180259insGGC	uc004awf.3	-	0	411_412	c.56_57insGCC	c.(55-57)ccc>ccGCCc	p.19_19P>PP	ZNF367_uc004awg.3_In_Frame_Ins_p.19_19P>PP	NM_153695	NP_710162	Q7RTV3	ZN367_HUMAN	Homo sapiens zinc finger protein 367 (ZNF367), mRNA.	19	Pro-rich.				regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(4)|large_intestine(3)|lung(3)|prostate(1)	12		Acute lymphoblastic leukemia(62;0.0167)				AGAAGATGACGggcggcggcgg	0.752													---	5	---	---	4	---					
MST1P9	11223	broad.mit.edu	37	1	17086085	17086086	+	Frame_Shift_Ins	INS	-	C	C			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr1:17086085_17086086insC	uc010ock.2	-	6	811_812	c.811_812insG	c.(811-813)gcgfs	p.A271fs	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.4_5'UTR					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 9 (MST1P9), non-coding RNA.											breast(1)|endometrium(11)|kidney(9)|large_intestine(1)|lung(5)|pancreas(1)|prostate(4)|stomach(1)|urinary_tract(1)	34						GGCAAGGTACGCCGCGGTGGTG	0.649													---	11	---	---	7	---					
CCDC28B	79140	broad.mit.edu	37	1	32670247	32670248	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr1:32670247_32670248delTG	uc021okt.1	+	4	706_707	c.574_575delTG	c.(574-576)tgtfs	p.C192fs	CCDC28B_uc001bul.1_Intron|IQCC_uc001bum.2_5'Flank|IQCC_uc009vua.2_5'Flank|IQCC_uc010ogz.1_5'Flank	NM_024296	NP_077272	Q9BUN5	CC28B_HUMAN	Homo sapiens coiled-coil domain containing 28B (CCDC28B), mRNA.	0								p.A192V(1)		large_intestine(4)|lung(3)|ovary(1)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				AACCCGTCTATGTGTGTGTGTT	0.500													---	212	---	---	9	---					
USP19	10869	broad.mit.edu	37	3	49148785	49148785	+	Frame_Shift_Del	DEL	C	-	-			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr3:49148785delC	uc003cwd.2	-	20	3241	c.2922delG	c.(2920-2922)gggfs	p.G974fs	USP19_uc003cwa.3_Frame_Shift_Del_p.G782fs|USP19_uc003cwb.3_Intron|USP19_uc003cvz.4_Frame_Shift_Del_p.G1077fs|USP19_uc011bcg.2_Frame_Shift_Del_p.G1065fs|USP19_uc003cwc.2_Frame_Shift_Del_p.G732fs|USP19_uc011bch.2_Frame_Shift_Del_p.G1075fs	NM_006677	NP_006668	O94966	UBP19_HUMAN	Homo sapiens ubiquitin specific peptidase 19 (USP19), transcript variant 4, mRNA.	974					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GATGCTGGTACCCAGGCACAG	0.532													---	87	---	---	20	---					
SMAP1	60682	broad.mit.edu	37	6	71508370	71508370	+	Frame_Shift_Del	DEL	A	-	-			TCGA-A4-8518-01A-11D-2396-08	TCGA-A4-8518-11A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f18659a-ddbf-48b6-a0b7-a17bfa7e924c	e4e19994-895c-4407-963a-b625f94f70d4	g.chr6:71508370delA	uc003pfr.3	+	5	754	c.506delA	c.(505-507)gaafs	p.E169fs	SMAP1_uc011dxy.1_Non-coding_Transcript|SMAP1_uc003pfs.3_Frame_Shift_Del_p.E142fs|SMAP1_uc010kao.3_Frame_Shift_Del_p.E142fs|SMAP1_uc010kap.3_Frame_Shift_Del_p.E159fs	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	Homo sapiens small ArfGAP 1 (SMAP1), transcript variant 1, mRNA.	169					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding	p.K145fs*48(1)		breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(1)	15						aaagaaaaggaaaaaaaaaag	0.289													---	5	---	---	4	---					
