Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDH8	1006	broad.mit.edu	37	16	61891030	61891030	+	Silent	SNP	A	C	C			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr16:61891030A>C	uc002eog.2	-	3	1615	c.660T>G	c.(658-660)ccT>ccG	p.P220P	CDH8_uc002eoh.3_5'UTR	NM_001796	NP_001787	P55286	CADH8_HUMAN	Homo sapiens cadherin 8, type 2 (CDH8), mRNA.	220	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AACCTGTTTCAGGCTCAATGG	0.393000														58			29		0	0	0.045705	0	0
PRRC1	133619	broad.mit.edu	37	5	126860252	126860252	+	Missense_Mutation	SNP	G	T	T			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr5:126860252G>T	uc003kuk.3	+	2	313	c.133G>T	c.(133-135)Gta>Tta	p.V45L	PRRC1_uc003kuj.4_Missense_Mutation_p.V45L	NM_130809	NP_570721	Q96M27	PRRC1_HUMAN	Homo sapiens proline-rich coiled-coil 1 (PRRC1), mRNA.	45	Pro-rich.					Golgi apparatus				endometrium(1)|large_intestine(1)|lung(4)	6		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		TTCTCCAAATGTATCCTCCAT	0.443000														317			24		3.01185e-09	4.30264e-09	0.091800	1	0
LUZP4	51213	broad.mit.edu	37	X	114541171	114541171	+	Silent	SNP	T	A	A			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chrX:114541171T>A	uc004eqa.3	+	3	778	c.744T>A	c.(742-744)acT>acA	p.T248T	LUZP4_uc004eqb.3_Silent_p.T166T	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	Homo sapiens leucine zipper protein 4 (LUZP4), mRNA.	248						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						TCATAGCCACTCAGAGAGATC	0.478000														147			6		0	0	0.029380	0	0
SNX13	23161	broad.mit.edu	37	7	17836512	17836512	+	Missense_Mutation	SNP	T	C	C			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr7:17836512T>C	uc003stv.3	-	24	2777	c.2564A>G	c.(2563-2565)gAt>gGt	p.D855G	SNX13_uc010kuc.3_Missense_Mutation_p.D652G|SNX13_uc003stw.1_Missense_Mutation_p.D866G|SNX13_uc010kub.3_Missense_Mutation_p.D261G	NM_015132	NP_055947	Q9Y5W8	SNX13_HUMAN	Homo sapiens sorting nexin 13 (SNX13), mRNA.	866					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					AATACTTTTATCTCTGCATGG	0.318000														108			10		0	0	0.105934	0	0
NPAS3	64067	broad.mit.edu	37	14	34263109	34263109	+	Missense_Mutation	SNP	A	G	G			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr14:34263109A>G	uc001wru.3	+	9	1224	c.1160A>G	c.(1159-1161)aAt>aGt	p.N387S	NPAS3_uc001wrs.3_Missense_Mutation_p.N374S|NPAS3_uc001wrv.3_Missense_Mutation_p.N357S|NPAS3_uc001wrt.3_Missense_Mutation_p.N355S	NM_001164749	NP_001158221	Q8IXF0	NPAS3_HUMAN	Homo sapiens neuronal PAS domain protein 3 (NPAS3), transcript variant 1, mRNA.	387	PAC.|PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CCAGTGCTGAATAAGGGTCAG	0.368000														159			12		0	0	0.020292	0	0
TMEFF2	23671	broad.mit.edu	37	2	193056717	193056717	+	Splice_Site	SNP	T	C	C			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr2:193056717T>C	uc002utc.3	-	2	567	c.173_splice	c.e2-1	p.G58_splice	TMEFF2_uc002utd.1_Splice_Site_p.G58_splice	NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	Homo sapiens transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2), mRNA.	58						extracellular region|integral to membrane				breast(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(12)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			CATCATAACCTCAAATTCAAA	0.333000														78			3		0	0	0.004672	0	0
IL17RC	84818	broad.mit.edu	37	3	9970113	9970113	+	Silent	SNP	T	G	G			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr3:9970113T>G	uc003bua.3	+	10	1433	c.1215T>G	c.(1213-1215)ggT>ggG	p.G405G	CIDEC_uc003bto.3_Intron|IL17RC_uc011ato.2_Non-coding_Transcript|IL17RC_uc010hcs.3_Silent_p.G309G|IL17RC_uc003btz.3_Silent_p.G334G|IL17RC_uc011atp.2_Silent_p.G190G|IL17RC_uc003bud.3_5'UTR|IL17RC_uc010hct.3_Silent_p.G334G|IL17RC_uc010hcu.3_Silent_p.G334G|IL17RC_uc003bub.3_Silent_p.G319G|IL17RC_uc010hcv.3_Silent_p.G319G|IL17RC_uc003buc.3_5'UTR|IL17RC_uc011atq.2_Silent_p.G319G|IL17RC_uc003bue.3_5'Flank	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	Homo sapiens interleukin 17 receptor C (IL17RC), transcript variant 2, mRNA.	405						integral to membrane|plasma membrane	receptor activity	p.G405G(2)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GGGCTCCGGGTGGGGACCCCT	0.682000														71			12		0	0	0.048971	0	0
ARSF	416	broad.mit.edu	37	X	3028196	3028196	+	Silent	SNP	C	T	T			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chrX:3028196C>T	uc022brz.1	+	9	1429	c.1293C>T	c.(1291-1293)ccC>ccT	p.P431P	ARSF_uc004cre.2_Silent_p.P431P|ARSF_uc004crf.2_Silent_p.P431P	NM_001201538	NP_001188467	P54793	ARSF_HUMAN	Homo sapiens arylsulfatase F (ARSF), transcript variant 2, mRNA.	431						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACCTCATGCCCTTGCTGCAGG	0.567000														213			8		0	0	0.047766	0	0
CPNE6	9362	broad.mit.edu	37	14	24544466	24544466	+	Missense_Mutation	SNP	C	A	A			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr14:24544466C>A	uc010tnv.2	+	8	1069	c.923C>A	c.(922-924)aCg>aAg	p.T308K	CPNE6_uc001wlm.3_Missense_Mutation_p.T78K|CPNE6_uc001wll.3_Missense_Mutation_p.T253K|CPNE6_uc001wln.3_5'Flank	NM_006032	NP_006023	O95741	CPNE6_HUMAN	Homo sapiens copine VI (neuronal) (CPNE6), mRNA.	253	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		CAGGAAGGGACGGCAAACCCT	0.567000														128			106		6.00573e-27	9.38395e-27	0.048971	1	0
ZC3H18	124245	broad.mit.edu	37	16	88694029	88694029	+	Splice_Site	SNP	G	C	C			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr16:88694029G>C	uc010voz.2	+	15	2381	c.2181_splice	c.e15-1	p.R727_splice	ZC3H18_uc002fky.3_Splice_Site_p.R703_splice|ZC3H18_uc010chw.3_Intron|ZC3H18_uc002fkz.3_5'UTR	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	Homo sapiens zinc finger CCCH-type containing 18 (ZC3H18), mRNA.	703	Ser-rich.					nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		TGTGTGTCCAGGTCCCTGAGC	0.602000														156			4		0	0	0.009096	0	0
THSD7B	80731	broad.mit.edu	37	2	138400116	138400116	+	Silent	SNP	C	T	T			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr2:138400116C>T	uc002tva.1	+	19	3768	c.3768C>T	c.(3766-3768)tgC>tgT	p.C1256C	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			Homo sapiens thrombospondin, type I, domain containing 7B (THSD7B), mRNA.											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GACGGCCATGCCCCACAGAGC	0.507000														188			4		0	0	0.014758	0	0
AMD1	262	broad.mit.edu	37	6	111208734	111208734	+	Missense_Mutation	SNP	A	G	G			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr6:111208734A>G	uc003puk.1	+	1	459	c.137A>G	c.(136-138)gAt>gGt	p.D46G	AMD1_uc011eay.1_5'UTR|AMD1_uc003pul.1_Intron|AMD1_uc011eaz.1_Intron|AMD1_uc011eba.1_Intron	NM_001634	NP_001028231	P17707	DCAM_HUMAN	Homo sapiens adenosylmethionine decarboxylase 1 (AMD1), transcript variant 1, mRNA.	46					spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(2)	8		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)	CTTTTGAAGGATGTGCAATGT	0.353000														202			41		0	0	0.045515	0	0
FBLN1	2192	broad.mit.edu	37	22	45929662	45929662	+	Missense_Mutation	SNP	G	A	A			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr22:45929662G>A	uc010gzz.3	+	7	929	c.782G>A	c.(781-783)gGc>gAc	p.G261D	FBLN1_uc003bgg.1_Missense_Mutation_p.G223D|FBLN1_uc003bgh.3_Missense_Mutation_p.G223D|FBLN1_uc003bgi.1_Missense_Mutation_p.G223D|FBLN1_uc003bgj.1_Missense_Mutation_p.G223D	NM_001996	NP_001987	P23142	FBLN1_HUMAN	Homo sapiens fibulin 1 (FBLN1), transcript variant C, mRNA.	223	EGF-like 2; calcium-binding (Potential).				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TGCATCACGGGCAGCCACAGC	0.567000														137			11		0	0	0.028581	0	0
PRRC2C	23215	broad.mit.edu	37	1	171553162	171553162	+	Missense_Mutation	SNP	C	T	T			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr1:171553162C>T	uc010pmg.2	+	28	7737	c.7471C>T	c.(7471-7473)Cac>Tac	p.H2491Y	PRRC2C_uc010pmh.2_Missense_Mutation_p.H1403Y|PRRC2C_uc010pmi.2_Missense_Mutation_p.H328Y|PRRC2C_uc010pmj.2_Missense_Mutation_p.H18Y	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	Homo sapiens proline-rich coiled-coil 2C (PRRC2C), mRNA.	2491	Gln-rich.						protein C-terminus binding										TACTGCTATTCACAACTTTCC	0.408000														123			65		0	0	0.048971	0	0
LDHB	3945	broad.mit.edu	37	12	21788543	21788543	+	Missense_Mutation	SNP	T	C	C			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr12:21788543T>C	uc001rfd.3	-	7	1271	c.938A>G	c.(937-939)gAg>gGg	p.E313G	LDHB_uc001rfe.3_Missense_Mutation_p.E313G	NM_001174097	NP_002291	P07195	LDHB_HUMAN	Homo sapiens lactate dehydrogenase B (LDHB), transcript variant 2, mRNA.	313					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	26					NADH(DB00157)	CTGAGCAACCTCATCATCCTT	0.458000														245			4		0	0	0.014758	0	0
GYLTL1B	120071	broad.mit.edu	37	11	45948105	45948105	+	Missense_Mutation	SNP	A	C	C			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr11:45948105A>C	uc001nbv.1	+	8	1232	c.1121A>C	c.(1120-1122)gAg>gCg	p.E374A	GYLTL1B_uc001nbw.1_Missense_Mutation_p.E343A|GYLTL1B_uc001nbx.1_Missense_Mutation_p.E374A	NM_152312	NP_689525	Q8N3Y3	LARG2_HUMAN	Homo sapiens glycosyltransferase-like 1B (GYLTL1B), mRNA.	374					muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(35;0.226)		CTGCGGAGAGAGCTCTTTGTG	0.567000														53			28		0	0	0.037714	0	0
C14orf142	84520	broad.mit.edu	37	14	93670051	93670051	+	Silent	SNP	C	T	T			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr14:93670051C>T	uc001ybl.1	-	1	362	c.285G>A	c.(283-285)cgG>cgA	p.R95R		NM_032490	NP_115879	Q9BXV9	CN142_HUMAN	Homo sapiens chromosome 14 open reading frame 142 (C14orf142), mRNA.	95										endometrium(1)|skin(1)	2		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.177)|all cancers(159;0.198)|COAD - Colon adenocarcinoma(157;0.203)		GTGTTTTTGGCCGTTTTGCAG	0.338000														167			4		0	0	0.021553	0	0
KIAA0141	9812	broad.mit.edu	37	5	141304998	141304998	+	Missense_Mutation	SNP	C	T	T	rs148625091		TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr5:141304998C>T	uc003lls.3	+	2	292	c.170C>T	c.(169-171)aCg>aTg	p.T57M	KIAA0141_uc003llt.3_Missense_Mutation_p.T57M	NM_001142603	NP_055588	Q14154	DELE_HUMAN	Homo sapiens KIAA0141 (KIAA0141), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.	57					apoptosis|regulation of caspase activity	mitochondrion	protein binding			endometrium(3)|large_intestine(4)|lung(5)|skin(1)|urinary_tract(3)	16		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCCAGGCACGAGCGGGGGT	0.567000														150			5		0	0	0.021553	0	0
GCOM1	145781	broad.mit.edu	37	15	57922023	57922023	+	Missense_Mutation	SNP	C	G	G			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr15:57922023C>G	uc002aei.3	+	5	780	c.649C>G	c.(649-651)Caa>Gaa	p.Q217E	GCOM1_uc002aej.3_Missense_Mutation_p.Q217E|GCOM1_uc002aek.3_Non-coding_Transcript|GCOM1_uc002ael.3_Non-coding_Transcript|GCOM1_uc002aem.3_Missense_Mutation_p.Q217E|GCOM1_uc002aep.3_Non-coding_Transcript|GCOM1_uc010bfx.3_Non-coding_Transcript|GCOM1_uc002aeq.3_Non-coding_Transcript|GCOM1_uc002aen.3_Non-coding_Transcript|GCOM1_uc010bfy.3_Non-coding_Transcript|GCOM1_uc002aeo.3_Missense_Mutation_p.Q217E	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	Homo sapiens myocardial zonula adherens protein (MYZAP), transcript variant 1, mRNA.	217					intracellular signal transduction	I band|extrinsic to internal side of plasma membrane				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GGAGGTAGCGCAAGTTGAAAA	0.413000														93			4		0	0	0.014758	0	0
OR8D1	283159	broad.mit.edu	37	11	124180427	124180427	+	Missense_Mutation	SNP	G	A	A			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr11:124180427G>A	uc010sag.2	-	0	236	c.236C>T	c.(235-237)cCc>cTc	p.P79L		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	Homo sapiens olfactory receptor, family 8, subfamily D, member 1 (OR8D1), mRNA.	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		CAGCATTTTGGGAGTAATGAC	0.458000														60			7		0	0	0.029380	0	0
MUC17	140453	broad.mit.edu	37	7	100676555	100676555	+	Missense_Mutation	SNP	C	T	T			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr7:100676555C>T	uc003uxp.1	+	2	1911	c.1858C>T	c.(1858-1860)Cca>Tca	p.P620S	MUC17_uc010lho.1_Non-coding_Transcript	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	Homo sapiens mucin 17, cell surface associated (MUC17), mRNA.	620	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.P620A(2)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCAACCTCAAC	0.478000														481			7		0	0	0.038147	0	0
BRD8	10902	broad.mit.edu	37	5	137506598	137506598	+	Silent	SNP	C	T	T			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr5:137506598C>T	uc003lcf.1	-	5	418	c.363G>A	c.(361-363)cgG>cgA	p.R121R	BRD8_uc021yea.1_5'UTR|BRD8_uc003lcg.3_Silent_p.R121R|BRD8_uc003lci.3_Silent_p.R121R|BRD8_uc011cym.2_Silent_p.R105R|BRD8_uc011cyn.1_Silent_p.R80R|BRD8_uc010jes.1_5'UTR	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	Homo sapiens bromodomain containing 8 (BRD8), transcript variant 2, mRNA.	121					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	NuA4 histone acetyltransferase complex|mitochondrion	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity	p.R121W(1)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTCTCTTTAGCCGTCTATAGG	0.398000														164			4		0	0	0.009096	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	rs121913377		TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome					69			43		0	0	0.045515	0	0
CORO1B	57175	broad.mit.edu	37	11	67206237	67206237	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr11:67206237G>C	uc001oll.2	-	10	1382	c.1249C>G	c.(1249-1251)Ccc>Gcc	p.P417A	PTPRCAP_uc001oli.1_5'Flank|CORO1B_uc001olk.1_Missense_Mutation_p.P417A|CORO1B_uc009yrt.1_Non-coding_Transcript	NM_001018070	NP_065174	Q9BR76	COR1B_HUMAN	Homo sapiens coronin, actin binding protein, 1B (CORO1B), transcript variant 2, mRNA.	417					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			GCCATGGCGGGCCGGCTGTCA	0.701000														1			5		0	0	0.029380	0	0
FBXO27	126433	broad.mit.edu	37	19	39521937	39521937	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr19:39521937G>C	uc002okh.3	-	2	470	c.388C>G	c.(388-390)Caa>Gaa	p.Q130E		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	Homo sapiens F-box protein 27 (FBXO27), mRNA.	130	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|urinary_tract(2)	17	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CCACCGTGTTGCACCATCCAC	0.587000														54			6		0	0	0.043863	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14754902	14754902	+	Missense_Mutation	SNP	G	A	A			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr18:14754902G>A	uc010dlo.2	+	3	695	c.515G>A	c.(514-516)aGc>aAc	p.S172N	ANKRD30B_uc010xak.2_Non-coding_Transcript|ANKRD30B_uc021uhy.1_Missense_Mutation_p.S172N	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	Homo sapiens ankyrin repeat domain 30B (ANKRD30B), mRNA.	172										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TTACAGGCTAGCCTCACACCC	0.308000														0			2		0	0	0.009096	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140187880	140187880	+	Missense_Mutation	SNP	G	A	A			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr5:140187880G>A	uc003lhi.2	+	0	1209	c.1108G>A	c.(1108-1110)Gcc>Acc	p.A370T	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Missense_Mutation_p.A370T|PCDHAC2_uc011daa.2_Missense_Mutation_p.A370T	NM_018907	NP_061730	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 4 (PCDHA4), transcript variant 1, mRNA.	385					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding	p.A370S(2)		NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAGTCATCGCCCTGATCAG	0.493000														138			4		0	0	0.009096	0	0
CELSR1	9620	broad.mit.edu	37	22	46785299	46785299	+	Missense_Mutation	SNP	A	G	G			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr22:46785299A>G	uc003bhw.1	-	17	6443	c.6443T>C	c.(6442-6444)cTc>cCc	p.L2148P	CELSR1_uc011arc.1_Missense_Mutation_p.L469P	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	Homo sapiens cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) (CELSR1), mRNA.	2148					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity|calcium ion binding|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ATTGCCAAAGAGCGTGCCCGT	0.667000														80			5		0	0	0.014758	0	0
KLRB1	3820	broad.mit.edu	37	12	9754098	9754098	+	Splice_Site	SNP	T	C	C			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr12:9754098T>C	uc010sgt.2	-	2	246	c.184_splice	c.e2+1	p.V62_splice		NM_002258	NP_002249	Q12918	KLRB1_HUMAN	Homo sapiens killer cell lectin-like receptor subfamily B, member 1 (KLRB1), mRNA.	62					cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|large_intestine(6)|lung(4)	12						CCCACTTACCTGAAACACTCA	0.463000														50			3		0	0	0.004672	0	0
TPTE	7179	broad.mit.edu	37	21	11014952	11014952	+	RNA	SNP	A	T	T			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr21:11014952A>T	uc002yis.1	-	6		c.1494T>A						P56180	TPTE_HUMAN	Homo sapiens transmembrane phosphatase with tensin homology (TPTE), transcript variant 2, mRNA.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CACATTGTCTACATTGCAGAA	0.333000														70			3		0	0	0.004672	0	0
CDH8	1006	broad.mit.edu	37	16	61891031	61891031	+	Missense_Mutation	SNP	G	T	T			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr16:61891031G>T	uc002eog.2	-	3	1614	c.659C>A	c.(658-660)cCt>cAt	p.P220H	CDH8_uc002eoh.3_5'UTR	NM_001796	NP_001787	P55286	CADH8_HUMAN	Homo sapiens cadherin 8, type 2 (CDH8), mRNA.	220	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ACCTGTTTCAGGCTCAATGGA	0.388000														58			29		1.30897e-18	1.92496e-18	0.041601	1	0
TBX4	9496	broad.mit.edu	37	17	59560359	59560359	+	Missense_Mutation	SNP	G	A	A			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr17:59560359G>A	uc010ddo.3	+	8	1286	c.1123G>A	c.(1123-1125)Gac>Aac	p.D375N	TBX4_uc002izi.3_Missense_Mutation_p.D374N|TBX4_uc010woy.2_Missense_Mutation_p.D375N	NM_018488	NP_060958	P57082	TBX4_HUMAN	Homo sapiens T-box 4 (TBX4), mRNA.	374					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CCCTCCCTACGACCAGCAAAT	0.597000														68			4		0	0	0.009096	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94639430	94639431	+	Frame_Shift_Ins	INS	-	A	A			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr1:94639430_94639431insA	uc001dqj.4	-	22	4149_4150	c.3780_3781insT	c.(3778-3783)tttgtgfs	p.F1260fs	ARHGAP29_uc009wdq.1_Intron	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	Homo sapiens Rho GTPase activating protein 29 (ARHGAP29), mRNA.	1260	Interaction with PTPN13/PTPL1.				Rho protein signal transduction	cytosol	Rho GTPase activator activity|metal ion binding			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CATCCCTACACAAATTGTGGAA	0.401													---	329	---	---	18	---					
WBP1L	54838	broad.mit.edu	37	10	104503830	104503830	+	Frame_Shift_Del	DEL	T	-	-			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr10:104503830delT	uc001kwf.4	+	0	104	c.20delT	c.(19-21)ctgfs	p.L7fs	WBP1L_uc009xxg.1_Non-coding_Transcript	NM_001083913	NP_001077382	Q9NX94	OPA1L_HUMAN	Homo sapiens chromosome 10 open reading frame 26 (C10orf26), transcript variant 1, mRNA.	0						integral to membrane											agaaggCTCCTGGGTGGCATG	0.692													---	4	---	---	2	---					
ZMYND15	84225	broad.mit.edu	37	17	4645266	4645266	+	Frame_Shift_Del	DEL	G	-	-			TCGA-AL-3467-01A-01D-1252-08	TCGA-AL-3467-10A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a74ffd4b-fa89-49ae-aa1d-3052a5440fa2	2ab402fb-392f-4441-a979-713a602c9cd3	g.chr17:4645266delG	uc002fyu.2	+	2	914	c.884delG	c.(883-885)cggfs	p.R295fs	CXCL16_uc002fyr.4_5'Flank|CXCL16_uc002fys.4_5'Flank|ZMYND15_uc002fyv.2_Frame_Shift_Del_p.R295fs|ZMYND15_uc002fyt.2_Frame_Shift_Del_p.R295fs	NM_001136046	NP_001129518	Q9H091	ZMY15_HUMAN	Homo sapiens zinc finger, MYND-type containing 15 (ZMYND15), transcript variant 1, mRNA.	295							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						ACCCCAATGCGGACATGGGGT	0.577													---	141	---	---	83	---					
