Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADSL	158	broad.mit.edu	37	22	40745897	40745897	+	Missense_Mutation	SNP	T	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr22:40745897T>A	uc003ayp.4	+	1	274	c.215T>A	c.(214-216)aTc>aAc	p.I72N	ADSL_uc003ays.4_Missense_Mutation_p.I72N	NM_000026	NP_000017	P30566	PUR8_HUMAN	Homo sapiens adenylosuccinate lyase (ADSL), transcript variant 1, mRNA.	72			I -> V (in ADSL deficiency; severe).		AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						CTGGAGAACATCGACTTCAAG	0.433000														39			8		0	0	0.006214	0	0
HDAC10	83933	broad.mit.edu	37	22	50684494	50684494	+	Silent	SNP	A	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr22:50684494A>G	uc003bkg.3	-	17	2051	c.1678T>C	c.(1678-1680)Ttg>Ctg	p.L560L	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc010hav.3_Silent_p.L540L|HDAC10_uc003bkh.3_Silent_p.L353L|HDAC10_uc003bkj.3_Non-coding_Transcript	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	Homo sapiens histone deacetylase 10 (HDAC10), transcript variant 1, mRNA.	560					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding			endometrium(2)|kidney(2)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	8		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ACCAAGCCCAAGATGCAGCTC	0.657000														38			3		0	0	0.014758	0	0
LOC401010	401010	broad.mit.edu	37	2	132201718	132201718	+	Missense_Mutation	SNP	T	C	C	rs2001215	by1000genomes	TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr2:132201718T>C	uc002tst.2	-	0	750	c.284A>G	c.(283-285)cAt>cGt	p.H95R						Homo sapiens nucleolar complex associated 2 homolog (S. cerevisiae) pseudogene (LOC401010), non-coding RNA.																		GATGTCCACATGGAGCTTCCC	0.597000														23			3		0	0	0.004672	0	0
FREM1	158326	broad.mit.edu	37	9	14801824	14801824	+	Missense_Mutation	SNP	C	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr9:14801824C>G	uc003zlm.3	-	20	4336	c.3520G>C	c.(3520-3522)Gtg>Ctg	p.V1174L	FREM1_uc010mic.3_Non-coding_Transcript	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	Homo sapiens FRAS1 related extracellular matrix 1 (FREM1), transcript variant 1, mRNA.	1174					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TCCAGGTCCACAGCGCTGATG	0.493000														97			29		0	0	0.013726	0	0
CUL3	8452	broad.mit.edu	37	2	225422410	225422410	+	Missense_Mutation	SNP	A	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr2:225422410A>G	uc010fwy.1	-	1	301	c.248T>C	c.(247-249)cTa>cCa	p.L83P	CUL3_uc010zls.1_Intron|CUL3_uc002vny.2_Missense_Mutation_p.L77P	NM_003590	NP_003581	Q13618	CUL3_HUMAN	Homo sapiens cullin 3 (CUL3), mRNA.	77					G1/S transition of mitotic cell cycle|cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		AACTTCTCTTAGTCCAGTGTA	0.333000														30			14		0	0	0.024245	0	0
PLAU	5328	broad.mit.edu	37	10	75672687	75672687	+	Missense_Mutation	SNP	T	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr10:75672687T>A	uc001jwa.3	+	4	345	c.199T>A	c.(199-201)Tca>Aca	p.S67T	C10orf55_uc001jvz.2_Intron|PLAU_uc010qkw.2_Missense_Mutation_p.S50T|PLAU_uc010qkx.2_5'UTR|PLAU_uc001jwb.3_Non-coding_Transcript|PLAU_uc001jwc.3_Missense_Mutation_p.S67T|PLAU_uc009xrq.1_Missense_Mutation_p.S31T	NM_002658	NP_002649	P00749	UROK_HUMAN	Homo sapiens plasminogen activator, urokinase (PLAU), transcript variant 1, mRNA.	67					blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	TGTAGATAAGTCAAAAACCTG	0.468000														43			6		0	0	0.021553	0	0
FLII	2314	broad.mit.edu	37	17	18150655	18150655	+	Missense_Mutation	SNP	A	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr17:18150655A>C	uc002gsr.1	-	20	2555	c.2504T>G	c.(2503-2505)tTc>tGc	p.F835C	FLII_uc002gsq.1_Missense_Mutation_p.F706C|FLII_uc010vxn.1_Missense_Mutation_p.F804C|FLII_uc010vxo.1_Missense_Mutation_p.F780C|FLII_uc002gss.1_Missense_Mutation_p.F834C	NM_002018	NP_002009	Q13045	FLII_HUMAN	Homo sapiens flightless I homolog (Drosophila) (FLII), transcript variant 1, mRNA.	835					multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					CCAATTCTTGAACTTGGCCTT	0.602000														79			16		0	0	0.024245	0	0
C5orf42	65250	broad.mit.edu	37	5	37187887	37187887	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr5:37187887G>C	uc011cpa.1	-	21	4100	c.3869C>G	c.(3868-3870)tCc>tGc	p.S1290C	C5orf42_uc003jks.2_Non-coding_Transcript|C5orf42_uc011coz.1_Missense_Mutation_p.S365C|C5orf42_uc011cpb.1_Missense_Mutation_p.S171C	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	Homo sapiens chromosome 5 open reading frame 42 (C5orf42), mRNA.	1290										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GCAACTATAGGATAACTTATC	0.373000														20			4		0	0	0.014758	0	0
LOC650368	650368	broad.mit.edu	37	11	3427739	3427739	+	RNA	SNP	T	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr11:3427739T>C	uc010qxs.1	+	8		c.732T>C			LOC650368_uc001lxy.2_Non-coding_Transcript					Homo sapiens asparagine-linked glycosylation 1-like pseudogene (LOC650368), non-coding RNA.																		GGTCGGTGGATCTGGGTGTCT	0.617000														52			3		0	0	0.004672	0	0
CRBN	51185	broad.mit.edu	37	3	3209360	3209360	+	Silent	SNP	T	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr3:3209360T>C	uc003bpq.3	-	4	675	c.645A>G	c.(643-645)agA>agG	p.R215R	CRBN_uc003bpr.3_Silent_p.R214R|CRBN_uc011aso.2_Silent_p.R152R	NM_016302	NP_057386	Q96SW2	CRBN_HUMAN	Homo sapiens cereblon (CRBN), transcript variant 1, mRNA.	215	Lon.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	11				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)		ATTGGTCTTCTCTTGAGACAG	0.363000														113			8		0	0	0.010729	0	0
GTF2I	2969	broad.mit.edu	37	7	74146900	74146900	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:74146900G>C	uc003uau.3	+	14	1571	c.1201G>C	c.(1201-1203)Gga>Cga	p.G401R	GTF2I_uc003uav.3_Missense_Mutation_p.G380R|GTF2I_uc003uaw.3_Missense_Mutation_p.G381R|GTF2I_uc003uay.3_Missense_Mutation_p.G379R|GTF2I_uc003uax.3_Missense_Mutation_p.G360R	NM_032999	NP_127492	P78347	GTF2I_HUMAN	Homo sapiens general transcription factor IIi (GTF2I), transcript variant 1, mRNA.	401					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						TTATGTAGAAGGACTTCCTGA	0.418000														50			26		0	0	0.045705	0	0
HOXA1	3198	broad.mit.edu	37	7	27134334	27134334	+	Missense_Mutation	SNP	C	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:27134334C>T	uc003sye.3	-	1	827	c.733G>A	c.(733-735)Gag>Aag	p.E245K	HOXA1_uc003syd.3_3'UTR|HOXA1_uc022aao.1_3'UTR|HOTAIRM1_uc003syg.3_5'Flank|HOTAIRM1_uc022aap.1_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	Homo sapiens homeobox A1 (HOXA1), transcript variant 1, mRNA.	245						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AACTCCTTCTCCAGTTCCGTG	0.582000														133			38		0	0	0.033182	0	0
PPIL2	23759	broad.mit.edu	37	22	22039049	22039049	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr22:22039049G>C	uc010gtj.1	+	9	677	c.561G>C	c.(559-561)gaG>gaC	p.E187D	PPIL2_uc002zvh.4_Missense_Mutation_p.E187D|PPIL2_uc002zvi.4_Missense_Mutation_p.E187D|PPIL2_uc002zvg.4_Missense_Mutation_p.E187D|PPIL2_uc011aij.2_Missense_Mutation_p.E166D|PPIL2_uc002zvk.4_5'Flank	NM_148175	NP_680480	Q13356	PPIL2_HUMAN	Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 2 (PPIL2), transcript variant 2, mRNA.	187					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					TAGATGAAGAGAAGGCCAAAC	0.547000														27			7		0	0	0.029380	0	0
CHRNA4	1137	broad.mit.edu	37	20	61982183	61982183	+	Missense_Mutation	SNP	T	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr20:61982183T>C	uc002yes.2	-	4	758	c.580A>G	c.(580-582)Atg>Gtg	p.M194V	CHRNA4_uc002yet.1_Missense_Mutation_p.M18V|CHRNA4_uc010gke.1_Missense_Mutation_p.M123V|CHRNA4_uc002yev.1_Missense_Mutation_p.M18V|CHRNA4_uc010gkf.1_Missense_Mutation_p.M18V	NM_000744	NP_000735	P43681	ACHA4_HUMAN	Homo sapiens cholinergic receptor, nicotinic, alpha 4 (CHRNA4), mRNA.	194					B cell activation|DNA repair|behavioral response to nicotine|calcium ion transport|cognition|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CGGCTGTGCATGTTCACCAGG	0.587000														64			22		0	0	0.012319	0	0
MMP13	4322	broad.mit.edu	37	11	102822873	102822873	+	Missense_Mutation	SNP	C	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr11:102822873C>G	uc001phl.3	-	4	696	c.667G>C	c.(667-669)Gag>Cag	p.E223Q		NM_002427	NP_002418	P45452	MMP13_HUMAN	Homo sapiens matrix metallopeptidase 13 (collagenase 3) (MMP13), mRNA.	223					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding	p.E223K(2)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TGGCCGAACTCATGCGCAGCA	0.433000														125			30		0	0	0.037714	0	0
SEMA7A	8482	broad.mit.edu	37	15	74708932	74708932	+	Missense_Mutation	SNP	A	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr15:74708932A>C	uc002axv.3	-	6	825	c.785T>G	c.(784-786)gTg>gGg	p.V262G	SEMA7A_uc010ulk.2_Missense_Mutation_p.V97G|SEMA7A_uc010ull.2_Missense_Mutation_p.V248G	NM_003612	NP_001139502	O75326	SEM7A_HUMAN	Homo sapiens semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A), transcript variant 1, mRNA.	262	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of axon extension|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						CAACTGGGCCACACGGGACAC	0.552000														42			17		0	0	0.028581	0	0
OR2A7	401427	broad.mit.edu	37	7	143956670	143956670	+	Missense_Mutation	SNP	C	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:143956670C>T	uc011kuc.2	-	0	52	c.52G>A	c.(52-54)Gtt>Att	p.V18I	OR2A9P_uc003wec.1_Intron|OR2A7_uc003wef.3_Non-coding_Transcript	NM_001005328	NP_001005328	Q96R45	OR2A7_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily A, member 7 (OR2A7), mRNA.	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P17S(1)		endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	6	Melanoma(164;0.14)					CTTGGGCCAACGGGAAATCCC	0.498000														264			18		0	0	0.034045	0	0
PEAK1	79834	broad.mit.edu	37	15	77406689	77406689	+	Silent	SNP	G	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr15:77406689G>A	uc021sqy.1	-	7	5626	c.5050C>T	c.(5050-5052)Cta>Tta	p.L1684L		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	Homo sapiens NKF3 kinase family member (PEAK1), mRNA.	1684					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										CTCTGTACTAGGCTAGGGCAG	0.542000														87			31		0	0	0.045705	0	0
FCN1	2219	broad.mit.edu	37	9	137801883	137801883	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr9:137801883G>C	uc004cfi.3	-	8	831	c.742C>G	c.(742-744)Cta>Gta	p.L248V		NM_002003	NP_001994	O00602	FCN1_HUMAN	Homo sapiens ficolin (collagen/fibrinogen domain containing) 1 (FCN1), mRNA.	248	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding	p.S247Y(1)		endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TGGCCCGTTAGAGAATTACCT	0.507000														171			41		0	0	0.045515	0	0
CUX1	1523	broad.mit.edu	37	7	101845410	101845410	+	Missense_Mutation	SNP	A	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:101845410A>T	uc003uys.4	+	17	2993	c.2866A>T	c.(2866-2868)Acc>Tcc	p.T956S	CUX1_uc003uyw.3_Intron|CUX1_uc003uyv.3_Intron|CUX1_uc003uyt.3_Intron|CUX1_uc003uyu.3_Intron|CUX1_uc011kkn.2_Intron|CUX1_uc003uyx.4_Missense_Mutation_p.T945S	NM_001202543	NP_001189472	P39880	CUX1_HUMAN	Homo sapiens cut-like homeobox 1 (CUX1), transcript variant 4, mRNA.	945					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						GGAGGTGGACACCATCGAGCT	0.612000														128			70		0	0	0.014410	0	0
KEL	3792	broad.mit.edu	37	7	142658089	142658089	+	Missense_Mutation	SNP	C	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:142658089C>A	uc003wcb.3	-	3	536	c.326G>T	c.(325-327)gGa>gTa	p.G109V		NM_000420	NP_000411	P23276	KELL_HUMAN	Homo sapiens Kell blood group, metallo-endopeptidase (KEL), mRNA.	109					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TTTGGCCCTTCCACAGGCAAA	0.512000														140			38		1.36161e-19	1.55121e-19	0.019004	1	0
RERE	473	broad.mit.edu	37	1	8415616	8415616	+	Silent	SNP	G	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr1:8415616G>T	uc001ape.3	-	22	5340	c.4530C>A	c.(4528-4530)ccC>ccA	p.P1510P	RERE_uc001apf.3_Silent_p.P1510P|RERE_uc001apd.3_Silent_p.P956P	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	Homo sapiens arginine-glutamic acid dipeptide (RE) repeats (RERE), transcript variant 1, mRNA.	1510	Pro-rich.				NLS-bearing substrate import into nucleus|multicellular organismal development	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CTGCTGACATGGGGGGTGGGA	0.642000														22			7		0.000157383	0.000166641	0.038147	1	0
PCLO	27445	broad.mit.edu	37	7	82763823	82763823	+	Missense_Mutation	SNP	C	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:82763823C>G	uc003uhx.2	-	2	3332	c.3043G>C	c.(3043-3045)Gct>Cct	p.A1015P	PCLO_uc003uhv.2_Missense_Mutation_p.A1015P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	Homo sapiens piccolo (presynaptic cytomatrix protein) (PCLO), transcript variant 1, mRNA.	961					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ACTGTTGGAGCTTGTTCAGCT	0.428000														32			13		0	0	0.016723	0	0
CYP3A7	1551	broad.mit.edu	37	7	99328744	99328744	+	Nonsense_Mutation	SNP	T	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:99328744T>A	uc003uru.3	-	1	206	c.103A>T	c.(103-105)Aag>Tag	p.K35*	ZNF498_uc003urn.3_Intron|CYP3A7_uc003urs.3_Intron|CYP3A7_uc010lgg.3_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 7 (CYP3A7), mRNA.	35					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					ATTCCAAGCTTCTTAAAAAGT	0.423000														73			50		0	0	0.014410	0	0
TSPAN2	10100	broad.mit.edu	37	1	115601516	115601516	+	Silent	SNP	G	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr1:115601516G>A	uc001eft.3	-	4	500	c.432C>T	c.(430-432)acC>acT	p.T144T	TSPAN2_uc021osc.1_Silent_p.T144T	NM_005725	NP_005716	O60636	TSN2_HUMAN	Homo sapiens tetraspanin 2 (TSPAN2), mRNA.	144						integral to membrane				central_nervous_system(1)|large_intestine(4)|lung(3)|pancreas(1)|prostate(1)	10	Lung SC(450;0.211)	all_cancers(81;2.9e-07)|all_epithelial(167;1.42e-06)|all_lung(203;6.72e-06)|Lung NSC(69;1.13e-05)|Acute lymphoblastic leukemia(138;0.191)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		TTGAGTGGAAGGTGATGAGTG	0.398000														111			35		0	0	0.021022	0	0
PRIM2	5558	broad.mit.edu	37	6	57246849	57246849	+	Silent	SNP	G	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr6:57246849G>T	uc003pdx.3	+	6	663	c.576G>T	c.(574-576)ctG>ctT	p.L192L	PRIM2_uc003pdw.3_Silent_p.L192L	NM_000947	NP_000938	P49643	PRI2_HUMAN	Homo sapiens primase, DNA, polypeptide 2 (58kDa) (PRIM2), mRNA.	192					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(34)|prostate(6)|stomach(4)|upper_aerodigestive_tract(1)	59				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CTGATGCTCTGGATTTGTTTC	0.368000														23			9		1.12685e-05	1.22189e-05	0.004482	1	0
ZNF780A	284323	broad.mit.edu	37	19	40581903	40581903	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr19:40581903G>C	uc010xvh.2	-	5	597	c.449C>G	c.(448-450)cCt>cGt	p.P150R	ZNF780A_uc002omw.4_Intron|ZNF780A_uc002omy.3_Missense_Mutation_p.P149R|ZNF780A_uc002omz.3_Missense_Mutation_p.P149R	NM_001142577	NP_001136049	O75290	Z780A_HUMAN	Homo sapiens zinc finger protein 780A (ZNF780A), transcript variant 1, mRNA.	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGTATGAGTAGGCAGTTTTTC	0.333000														54			16		0	0	0.028581	0	0
PER1	5187	broad.mit.edu	37	17	8047060	8047060	+	Missense_Mutation	SNP	T	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr17:8047060T>G	uc002gkd.3	-	18	2834	c.2596A>C	c.(2596-2598)Acc>Ccc	p.T866P	PER1_uc010cns.3_5'Flank|PER1_uc010vuq.2_Intron	NM_002616	NP_002607	O15534	PER1_HUMAN	Homo sapiens period homolog 1 (Drosophila) (PER1), mRNA.	866	Pro-rich.				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity	p.T866P(2)		breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GGCCAGGGGGTGGAGGGTGGC	0.667000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes						19			4		0	0	0.021553	0	0
DIAPH3	81624	broad.mit.edu	37	13	60566699	60566699	+	Missense_Mutation	SNP	T	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr13:60566699T>A	uc001vht.3	-	9	1252	c.1033A>T	c.(1033-1035)Atc>Ttc	p.I345F	DIAPH3_uc001vhu.3_Missense_Mutation_p.I82F|DIAPH3_uc001vhv.3_5'Flank|DIAPH3_uc001vhw.1_Missense_Mutation_p.I334F|DIAPH3_uc010aed.1_Missense_Mutation_p.I299F|DIAPH3_uc010aee.1_Missense_Mutation_p.I275F	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	Homo sapiens diaphanous homolog 3 (Drosophila) (DIAPH3), transcript variant 1, mRNA.	345	GBD/FH3.				actin cytoskeleton organization		Rho GTPase binding|actin binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AGGGCATTGATGAGCTGCATA	0.393000														32			6		0	0	0.038147	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3483103	3483103	+	Silent	SNP	G	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr2:3483103G>A	uc002qxm.1	+	11	2285	c.2079G>A	c.(2077-2079)gtG>gtA	p.V693V	TRAPPC12_uc002qxn.1_Silent_p.V693V|TRAPPC12_uc010ewm.1_Intron	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	Homo sapiens trafficking protein particle complex 12 (TRAPPC12), mRNA.	693							binding										ACGAGAGCGTGCTCTTCAACC	0.632000														80			29		0	0	0.030593	0	0
SH2B3	10019	broad.mit.edu	37	12	111885276	111885276	+	Silent	SNP	G	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr12:111885276G>A	uc001tsf.3	+	4	1194	c.1167G>A	c.(1165-1167)gtG>gtA	p.V389V	SH2B3_uc001tse.3_Silent_p.V388V|SH2B3_uc010syf.2_Silent_p.V388V|SH2B3_uc010syg.2_Silent_p.V186V	NM_005475	NP_005466	Q9UQQ2	SH2B3_HUMAN	Homo sapiens SH2B adaptor protein 3 (SH2B3), mRNA.	388	SH2.				blood coagulation	cytosol	signal transducer activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	10						CTCATGGAGTGTTCCTGGTGC	0.617000														112			25		0	0	0.018920	0	0
FKBP4	2288	broad.mit.edu	37	12	2910328	2910328	+	Missense_Mutation	SNP	G	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr12:2910328G>A	uc001qkz.3	+	8	1276	c.1078G>A	c.(1078-1080)Gga>Aga	p.G360R		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	Homo sapiens FK506 binding protein 4, 59kDa (FKBP4), mRNA.	360	Interaction with tubulin (By similarity).				negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(1)	14			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	CTTCCGCCGGGGAGAGGCCCA	0.572000														99			30		0	0	0.041601	0	0
CUL3	8452	broad.mit.edu	37	2	225449722	225449722	+	Nonsense_Mutation	SNP	G	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr2:225449722G>T	uc002vny.2	-	0	389	c.5C>A	c.(4-6)tCg>tAg	p.S2*	CUL3_uc010zls.1_Nonsense_Mutation_p.S2*	NM_003590	NP_003581	Q13618	CUL3_HUMAN	Homo sapiens cullin 3 (CUL3), mRNA.	2					G1/S transition of mitotic cell cycle|cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		GCTCAGATTCGACATGGTGCT	0.706000														20			6		1.06961e-07	1.18846e-07	0.038147	1	0
KIAA2022	340533	broad.mit.edu	37	X	73961092	73961092	+	Silent	SNP	C	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chrX:73961092C>T	uc004eby.3	-	2	3917	c.3300G>A	c.(3298-3300)gaG>gaA	p.E1100E		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	Homo sapiens KIAA2022 (KIAA2022), mRNA.	1100					DNA replication proofreading|DNA replication, removal of RNA primer|S phase of mitotic cell cycle|base-excision repair, gap-filling|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						CTGGGACACCCTCTTGGAACC	0.478000														76			4		0	0	0.009096	0	0
DDX54	79039	broad.mit.edu	37	12	113610194	113610194	+	Missense_Mutation	SNP	A	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr12:113610194A>G	uc001tuq.4	-	10	1271	c.1243T>C	c.(1243-1245)Ttc>Ctc	p.F415L	DDX54_uc001tup.3_Missense_Mutation_p.F415L	NM_001111322	NP_001104792	Q8TDD1	DDX54_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 (DDX54), transcript variant 1, mRNA.	415	Helicase C-terminal.				RNA processing|estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|RNA binding|estrogen receptor binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						TTGGCGGGGAAGCTGTAGTTG	0.637000														25			17		0	0	0.008871	0	0
MGAT3	4248	broad.mit.edu	37	22	39883780	39883780	+	Missense_Mutation	SNP	C	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr22:39883780C>G	uc003axv.4	+	1	667	c.428C>G	c.(427-429)tCc>tGc	p.S143C	MGAT3_uc010gxy.3_Missense_Mutation_p.S143C	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	Homo sapiens mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (MGAT3), transcript variant 1, mRNA.	143					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GCCAACGGCTCCTCGGCCCGG	0.766000														0			4		0	0	0.009096	0	0
KERA	11081	broad.mit.edu	37	12	91449805	91449805	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr12:91449805G>C	uc001tbl.3	-	1	873	c.254C>G	c.(253-255)aCc>aGc	p.T85S		NM_007035	NP_008966	O60938	KERA_HUMAN	Homo sapiens keratocan (KERA), mRNA.	85					response to stimulus|visual perception	proteinaceous extracellular matrix				breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						TTCAGGAATGGTTTCTATCAG	0.353000														80			15		0	0	0.024245	0	0
PRIM2	5558	broad.mit.edu	37	6	57246850	57246850	+	Missense_Mutation	SNP	G	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr6:57246850G>T	uc003pdx.3	+	6	664	c.577G>T	c.(577-579)Gat>Tat	p.D193Y	PRIM2_uc003pdw.3_Missense_Mutation_p.D193Y	NM_000947	NP_000938	P49643	PRI2_HUMAN	Homo sapiens primase, DNA, polypeptide 2 (58kDa) (PRIM2), mRNA.	193					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(34)|prostate(6)|stomach(4)|upper_aerodigestive_tract(1)	59				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TGATGCTCTGGATTTGTTTCG	0.368000														23			9		1.12685e-05	1.22189e-05	0.004482	1	0
CD163	9332	broad.mit.edu	37	12	7640255	7640255	+	Missense_Mutation	SNP	G	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr12:7640255G>A	uc001qsz.3	-	7	1878	c.1750C>T	c.(1750-1752)Cgc>Tgc	p.R584C	CD163_uc001qta.3_Missense_Mutation_p.R584C|CD163_uc009zfw.2_Missense_Mutation_p.R617C	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	Homo sapiens CD163 molecule (CD163), transcript variant 1, mRNA.	584	SRCR 6.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity	p.R584C(2)		breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						TTCACCAAGCGAATTTCTGTG	0.488000														135			8		0	0	0.004482	0	0
PRKX	5613	broad.mit.edu	37	X	3544550	3544550	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chrX:3544550G>C	uc010nde.3	-	4	1106	c.725C>G	c.(724-726)cCt>cGt	p.P242R		NM_005044	NP_005035	P51817	PRKX_HUMAN	Homo sapiens protein kinase, X-linked (PRKX), mRNA.	242	Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(2)	12		all_lung(23;0.000396)|Lung NSC(23;0.00123)				AAAAAACGGAGGAAACCTGTT	0.373000														14			6		0	0	0.029380	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 1 (NBPF1), mRNA.							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000														45			5		0	0	0.021553	0	0
WDR74	54663	broad.mit.edu	37	11	62606983	62606983	+	Missense_Mutation	SNP	C	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr11:62606983C>G	uc001nvm.2	-	1	228	c.60G>C	c.(58-60)ttG>ttC	p.L20F	WDR74_uc001nvl.2_Missense_Mutation_p.L20F|WDR74_uc009yoi.2_Missense_Mutation_p.L20F|WDR74_uc010rmk.2_Missense_Mutation_p.L20F	NM_018093	NP_060563	Q6RFH5	WDR74_HUMAN	Homo sapiens WD repeat domain 74 (WDR74), mRNA.	20						nucleolus				kidney(2)|large_intestine(1)|liver(1)|lung(3)|ovary(1)	8						ACCCACCTTTCAAGATCCCAG	0.632000														57			23		0	0	0.016522	0	0
EGF	1950	broad.mit.edu	37	4	110865158	110865158	+	Missense_Mutation	SNP	A	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr4:110865158A>T	uc003hzy.4	+	3	1122	c.670A>T	c.(670-672)Agc>Tgc	p.S224C	EGF_uc011cfu.2_Missense_Mutation_p.S224C|EGF_uc011cfv.2_Missense_Mutation_p.S224C	NM_001963	NP_001954	P01133	EGF_HUMAN	Homo sapiens epidermal growth factor (EGF), transcript variant 1, mRNA.	224					DNA replication|angiogenesis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of MAP kinase activity|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CAGAGAAGGAAGCAATTCTCT	0.388000														38			17		0	0	0.043863	0	0
C7	730	broad.mit.edu	37	5	40964972	40964972	+	Missense_Mutation	SNP	C	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr5:40964972C>G	uc003jmh.3	+	13	1993	c.1879C>G	c.(1879-1881)Cag>Gag	p.Q627E	C7_uc011cpn.1_Non-coding_Transcript	NM_000587	NP_000578	P10643	CO7_HUMAN	Homo sapiens complement component 7 (C7), mRNA.	627	Sushi 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				AATGCATTGTCAGAGTGAGTG	0.403000														121			7		0	0	0.029380	0	0
MAGI2	9863	broad.mit.edu	37	7	78131031	78131031	+	Silent	SNP	C	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:78131031C>A	uc003ugx.3	-	4	1082	c.828G>T	c.(826-828)gtG>gtT	p.V276V	MAGI2_uc003ugy.3_Silent_p.V276V|MAGI2_uc011kgr.1_Silent_p.V108V|MAGI2_uc011kgs.1_Silent_p.V113V	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2), mRNA.	276	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GCTGACTGTACACTGGTGCAG	0.493000														79			20		4.35082e-09	4.89467e-09	0.010504	1	0
SESTD1	91404	broad.mit.edu	37	2	180016091	180016091	+	Missense_Mutation	SNP	T	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr2:180016091T>A	uc002uni.4	-	5	547	c.397A>T	c.(397-399)Act>Tct	p.T133S		NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	Homo sapiens SEC14 and spectrin domains 1 (SESTD1), mRNA.	133	CRAL-TRIO.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			ATATAACGAGTCAATTTGTTG	0.353000														20			16		0	0	0.028581	0	0
RGL1	23179	broad.mit.edu	37	1	183885638	183885638	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr1:183885638G>C	uc001gqm.3	+	16	2373	c.1912G>C	c.(1912-1914)Ggg>Cgg	p.G638R	RGL1_uc010pog.2_Missense_Mutation_p.G601R|RGL1_uc010poh.2_Missense_Mutation_p.G601R|RGL1_uc001gqo.3_Missense_Mutation_p.G603R|RGL1_uc010poi.2_Missense_Mutation_p.G574R	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	Homo sapiens ral guanine nucleotide dissociation stimulator-like 1 (RGL1), mRNA.	603					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ral guanyl-nucleotide exchange factor activity|protein binding			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						AAATTCCTCAGGGATGTCTTC	0.502000														111			41		0	0	0.033182	0	0
FETUB	26998	broad.mit.edu	37	3	186362554	186362554	+	Missense_Mutation	SNP	A	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr3:186362554A>G	uc010hyq.3	+	4	700	c.439A>G	c.(439-441)Att>Gtt	p.I147V	FETUB_uc011brz.2_5'UTR|FETUB_uc003fqn.3_Missense_Mutation_p.I147V|FETUB_uc010hyr.3_Missense_Mutation_p.I110V|FETUB_uc010hys.3_5'UTR|FETUB_uc003fqp.4_Missense_Mutation_p.I82V	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	Homo sapiens fetuin B (FETUB), mRNA.	147						extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		AAAAAAAAAGATTTACATGAC	0.408000														65			23		0	0	0.018920	0	0
ESRRA	2101	broad.mit.edu	37	11	64074935	64074935	+	Missense_Mutation	SNP	C	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr11:64074935C>A	uc001nzq.1	+	1	461	c.284C>A	c.(283-285)tCc>tAc	p.S95Y	ESRRA_uc001nzr.1_Missense_Mutation_p.S95Y|ESRRA_uc001nzs.1_Missense_Mutation_p.S95Y	NM_004451	NP_004442	P11474	ERR1_HUMAN	Homo sapiens estrogen-related receptor alpha (ESRRA), mRNA.	95					positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14						GGTGTGGCATCCTGTGAGGCC	0.657000														25			5		3.59834e-05	3.85536e-05	0.021553	1	0
COMMD2	51122	broad.mit.edu	37	3	149468478	149468478	+	Missense_Mutation	SNP	C	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr3:149468478C>T	uc003exj.2	-	3	444	c.389G>A	c.(388-390)cGa>cAa	p.R130Q		NM_016094	NP_057178	Q86X83	COMD2_HUMAN	Homo sapiens COMM domain containing 2 (COMMD2), mRNA.	130	COMM.						protein binding			NS(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	9			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TACATCTAGTCGCCATTCAAG	0.333000														83			19		0	0	0.014323	0	0
ARFRP1	10139	broad.mit.edu	37	20	62333531	62333531	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr20:62333531G>C	uc002ygf.3	-	4	446	c.303C>G	c.(301-303)gaC>gaG	p.D101E	ARFRP1_uc002yga.3_Missense_Mutation_p.D101E|ARFRP1_uc011abf.2_Missense_Mutation_p.D101E|ARFRP1_uc002ygh.4_Missense_Mutation_p.D101E|ARFRP1_uc002ygc.3_Missense_Mutation_p.D101E|ARFRP1_uc011abg.2_Missense_Mutation_p.D101E|ARFRP1_uc011abh.2_Non-coding_Transcript	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	Homo sapiens ADP-ribosylation factor related protein 1 (ARFRP1), transcript variant 1, mRNA.	101					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			CGTCGGTGGAGTCAATGACGT	0.632000														38			17		0	0	0.038395	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74915493	74915493	+	Silent	SNP	C	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr11:74915493C>T	uc001owb.3	+	13	2393	c.1998C>T	c.(1996-1998)ttC>ttT	p.F666F	SLCO2B1_uc010rrr.2_Silent_p.F522F|SLCO2B1_uc010rrs.2_Silent_p.F550F|SLCO2B1_uc001owc.3_Silent_p.F439F|SLCO2B1_uc001owd.3_Silent_p.F644F	NM_007256	NP_001138683	O94956	SO2B1_HUMAN	Homo sapiens solute carrier organic anion transporter family, member 2B1 (SLCO2B1), transcript variant 1, mRNA.	666					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	TGATCTGCTTCGCCTTAGTTT	0.552000														86			24		0	0	0.021523	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20130720	20130720	+	Missense_Mutation	SNP	C	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr22:20130720C>T	uc002zrr.2	+	9	1674	c.1567C>T	c.(1567-1569)Cgc>Tgc	p.R523C	ZDHHC8_uc002zrq.3_Missense_Mutation_p.R523C|ZDHHC8_uc010gsa.3_Missense_Mutation_p.R329C	NM_001185024	NP_001171953	Q9ULC8	ZDHC8_HUMAN	Homo sapiens zinc finger, DHHC-type containing 8 (ZDHHC8), transcript variant 1, mRNA.	523						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					GCCCCTACCCCGCAGCTTCAG	0.706000														36			12		0	0	0.016723	0	0
LUC7L2	51631	broad.mit.edu	37	7	139030365	139030365	+	Missense_Mutation	SNP	A	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:139030365A>T	uc011kqt.2	+	1	491	c.257A>T	c.(256-258)aAg>aTg	p.K86M	LUC7L2_uc011kqs.2_Intron|LUC7L2_uc003vuw.4_Missense_Mutation_p.K86M	NM_001244584	NP_001231513	Q9Y383	LC7L2_HUMAN	Homo sapiens LUC7-like 2 (S. cerevisiae) (LUC7L2), transcript variant 2, mRNA.	0							enzyme binding|metal ion binding			NS(2)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	16	Melanoma(164;0.242)					TTTCATGGCAAGGGTGAGCGC	0.562000														52			12		0	0	0.020292	0	0
ZPBP2	124626	broad.mit.edu	37	17	38027753	38027753	+	Missense_Mutation	SNP	T	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr17:38027753T>C	uc002hte.3	+	3	434	c.281T>C	c.(280-282)cTg>cCg	p.L94P	ZPBP2_uc002htf.3_Missense_Mutation_p.L72P	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	Homo sapiens zona pellucida binding protein 2 (ZPBP2), transcript variant 2, mRNA.	94					binding of sperm to zona pellucida	extracellular region				kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			ACTGGACAGCTGATGGTGAAA	0.294000														35			13		0	0	0.020292	0	0
PLVAP	83483	broad.mit.edu	37	19	17476968	17476968	+	Missense_Mutation	SNP	T	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr19:17476968T>C	uc002ngk.1	-	1	446	c.406A>G	c.(406-408)Atc>Gtc	p.I136V		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	Homo sapiens plasmalemma vesicle associated protein (PLVAP), mRNA.	136						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTCAAGATGATGGCAGCCATG	0.552000														112			44		0	0	0.014410	0	0
TAF15	8148	broad.mit.edu	37	17	34149828	34149828	+	Missense_Mutation	SNP	C	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr17:34149828C>T	uc002hkd.3	+	5	561	c.475C>T	c.(475-477)Cac>Tac	p.H159Y	TAF15_uc010ctw.1_Non-coding_Transcript|TAF15_uc002hkc.3_Missense_Mutation_p.H156Y	NM_139215	NP_631961	Q92804	RBP56_HUMAN	Homo sapiens TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa (TAF15), transcript variant 1, mRNA.	159	Gln/Gly/Ser/Tyr-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|RNA binding|nucleotide binding|protein binding|zinc ion binding		TAF15/NR4A3(33)	lung(1)|ovary(1)|skin(2)|stomach(1)	5		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		CTACAGCCACCACACACAAGG	0.373000			T	"""TEC, CHN1, ZNF384"""	"""extraskeletal myxoid chondrosarcomas, ALL"""									72			5		0	0	0.021553	0	0
FSTL5	56884	broad.mit.edu	37	4	162697048	162697048	+	Silent	SNP	A	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr4:162697048A>G	uc003iqh.3	-	4	1024	c.588T>C	c.(586-588)gaT>gaC	p.D196D	FSTL5_uc003iqi.3_Silent_p.D195D|FSTL5_uc010iqv.3_Silent_p.D195D	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	Homo sapiens follistatin-like 5 (FSTL5), transcript variant 1, mRNA.	196	EF-hand 1.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		GTTCATTAATATCTACAAGTC	0.289000														53			3		0	0	0.009096	0	0
SPINK5	11005	broad.mit.edu	37	5	147510840	147510840	+	Missense_Mutation	SNP	G	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr5:147510840G>C	uc003lox.2	+	30	3056	c.2983G>C	c.(2983-2985)Gac>Cac	p.D995H	SPINK5_uc003loy.2_Missense_Mutation_p.D1025H	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	Homo sapiens serine peptidase inhibitor, Kazal type 5 (SPINK5), transcript variant 2, mRNA.	995	Kazal-like 15.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity	p.K994R(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGTGCAAAGACTACCGAGT	0.433000														160			34		0	0	0.025465	0	0
ZNF423	23090	broad.mit.edu	37	16	49670185	49670185	+	Missense_Mutation	SNP	T	C	C			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr16:49670185T>C	uc002efs.3	-	4	3176	c.2878A>G	c.(2878-2880)Atg>Gtg	p.M960V	ZNF423_uc010vgn.2_Missense_Mutation_p.M843V	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	Homo sapiens zinc finger protein 423 (ZNF423), mRNA.	960					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				ATGGGACACATGTAGTGCTTG	0.602000														42			10		0	0	0.010729	0	0
MET	4233	broad.mit.edu	37	7	116417463	116417463	+	Missense_Mutation	SNP	C	T	T	rs121913244		TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr7:116417463C>T	uc003vij.3	+	15	3467	c.3280C>T	c.(3280-3282)Cat>Tat	p.H1094Y	MET_uc010lkh.3_Missense_Mutation_p.H1112Y|MET_uc011knj.2_Missense_Mutation_p.H664Y	NM_000245	NP_000236	P08581	MET_HUMAN	Homo sapiens met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, mRNA.	1094	Protein kinase.		H -> L (in RCCP; constitutive autophosphorylation; causes malignant transformation in cell lines).|H -> R (in RCCP; causes malignant transformation in cell lines).|H -> Y (in RCCP; constitutive autophosphorylation; causes malignant transformation in cell lines).		axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.L1094L(1)|p.Q1029_G1105del(1)|p.H1112Y(1)		NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTGTGTATATCATGGGACTTT	0.343000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)					93			50		0	0	0.014410	0	0
CPNE6	9362	broad.mit.edu	37	14	24545747	24545747	+	Silent	SNP	G	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr14:24545747G>A	uc010tnv.2	+	13	1457	c.1311G>A	c.(1309-1311)ccG>ccA	p.P437P	CPNE6_uc001wlm.3_Silent_p.P207P|CPNE6_uc001wll.3_Silent_p.P382P|CPNE6_uc001wln.3_Missense_Mutation_p.R9Q	NM_006032	NP_006023	O95741	CPNE6_HUMAN	Homo sapiens copine VI (neuronal) (CPNE6), mRNA.	382	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		ACTTTGACCCGGAAAATCCTG	0.587000														58			26		0	0	0.027356	0	0
FBXO43	286151	broad.mit.edu	37	8	101152996	101152996	+	Missense_Mutation	SNP	C	G	G			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr8:101152996C>G	uc003yjd.3	-	1	2222	c.1486G>C	c.(1486-1488)Gac>Cac	p.D496H	FBXO43_uc003yje.3_Missense_Mutation_p.D462H|FBXO43_uc010mbp.2_Missense_Mutation_p.D496H	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	Homo sapiens F-box protein 43 (FBXO43), transcript variant 2, mRNA.	496	F-box.				meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			GTTAAGATGTCCAGTTTTTCT	0.388000														115			33		0	0	0.045705	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr15:102515299G>A	uc002cdi.3	+	8	1943	c.523G>A	c.(523-525)Ggc>Agc	p.G175S	WASH3P_uc010bpo.3_Non-coding_Transcript|WASH3P_uc002cdq.3_Non-coding_Transcript|WASH3P_uc002cdr.3_Non-coding_Transcript					Homo sapiens WAS protein family homolog 3 pseudogene (WASH3P), non-coding RNA.									p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000														20			4		0	0	0.021553	0	0
LOC401010	401010	broad.mit.edu	37	2	132201736	132201736	+	Missense_Mutation	SNP	C	G	G	rs2076798	by1000genomes	TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr2:132201736C>G	uc002tst.2	-	0	732	c.266G>C	c.(265-267)cGg>cCg	p.R89P						Homo sapiens nucleolar complex associated 2 homolog (S. cerevisiae) pseudogene (LOC401010), non-coding RNA.																		CCCCCAGAGCCGGCTGCTGGA	0.592000														20			3		0	0	0.004672	0	0
PARVG	64098	broad.mit.edu	37	22	44581694	44581694	+	Missense_Mutation	SNP	A	T	T			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr22:44581694A>T	uc011aqe.2	+	3	510	c.86A>T	c.(85-87)aAg>aTg	p.K29M	PARVG_uc010gzo.3_Missense_Mutation_p.K96M|PARVG_uc021wra.1_Missense_Mutation_p.K29M|PARVG_uc003bep.3_Missense_Mutation_p.K29M|PARVG_uc010gzq.1_Non-coding_Transcript|PARVG_uc021wrb.1_Missense_Mutation_p.K29M|PARVG_uc011aqf.2_Missense_Mutation_p.K29M|PARVG_uc021wrc.1_Non-coding_Transcript	NM_001137605	NP_071424	Q9HBI0	PARVG_HUMAN	Homo sapiens parvin, gamma (PARVG), transcript variant 2, mRNA.	29					cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)	17		Ovarian(80;0.024)|all_neural(38;0.0299)				CCAGGAGGAAAGAAGAAATAC	0.577000														27			9		0	0	0.006214	0	0
NLRP7	199713	broad.mit.edu	37	19	55449434	55449434	+	Missense_Mutation	SNP	T	A	A			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr19:55449434T>A	uc002qih.4	-	4	2183	c.2107A>T	c.(2107-2109)Acc>Tcc	p.T703S	NLRP7_uc010esk.3_Missense_Mutation_p.T703S|NLRP7_uc002qig.4_Missense_Mutation_p.T675S|NLRP7_uc002qii.4_Missense_Mutation_p.T703S|NLRP7_uc010esl.3_Missense_Mutation_p.T731S	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	Homo sapiens NLR family, pyrin domain containing 7 (NLRP7), transcript variant 2, mRNA.	703							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		AGATGACAGGTGCTACGGGTT	0.428000														244			81		0	0	0.014410	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186790685	186790685	+	Frame_Shift_Del	DEL	G	-	-			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr3:186790685delG	uc003frb.3	+	5	1387	c.754delG	c.(754-756)ggafs	p.G252fs	ST6GAL1_uc003frc.3_Frame_Shift_Del_p.G21fs|ST6GAL1_uc003frd.3_Frame_Shift_Del_p.G252fs	NM_173216	NP_775323	P15907	SIAT1_HUMAN	Homo sapiens ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (ST6GAL1), transcript variant 1, mRNA.	252					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|extracellular region|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		GTACAATGAAGGAATCCTAAT	0.433													---	113	---	---	29	---					
ITGA1	3672	broad.mit.edu	37	5	52204750	52204750	+	Frame_Shift_Del	DEL	T	-	-			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr5:52204750delT	uc003jou.3	+	12	1892	c.1478delT	c.(1477-1479)attfs	p.I493fs	ITGA1_uc003jov.3_Non-coding_Transcript|ITGA1_uc003jow.3_Frame_Shift_Del_p.I24fs	NM_181501	NP_852478	P56199	ITA1_HUMAN	Homo sapiens integrin, alpha 1 (ITGA1), mRNA.	493					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				TTTGGCAGTATTTTAACAACA	0.383													---	114	---	---	31	---					
LARS	51520	broad.mit.edu	37	5	145552256	145552256	+	Frame_Shift_Del	DEL	T	-	-			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr5:145552256delT	uc003lnx.1	-	2	445	c.207delA	c.(205-207)aaafs	p.K69fs	LARS_uc011dbq.1_Frame_Shift_Del_p.K69fs|LARS_uc011dbr.1_Frame_Shift_Del_p.K15fs|LARS_uc011dbs.1_Frame_Shift_Del_p.K69fs	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	Homo sapiens leucyl-tRNA synthetase (LARS), mRNA.	69					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TTACCTCACATTTGGATAAAG	0.353													---	40	---	---	23	---					
CDK8	1024	broad.mit.edu	37	13	26975735	26975736	+	Frame_Shift_Del	DEL	GG	-	-			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr13:26975735_26975736delGG	uc001uqr.1	+	11	1266_1267	c.1243_1244delGG	c.(1243-1245)ggafs	p.G415fs	CDK8_uc001uqs.1_Frame_Shift_Del_p.G414fs|CDK8_uc001uqt.1_Frame_Shift_Del_p.G242fs	NM_001260	NP_001251	P49336	CDK8_HUMAN	Homo sapiens cyclin-dependent kinase 8 (CDK8), mRNA.	415					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		TACCTCAGGTGGACTTATCATG	0.446													---	86	---	---	11	---					
ANKDD1A	348094	broad.mit.edu	37	15	65214185	65214185	+	Frame_Shift_Del	DEL	A	-	-			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr15:65214185delA	uc002aoa.3	+	3	362	c.333delA	c.(331-333)gtafs	p.V111fs	ANKDD1A_uc002anx.1_Frame_Shift_Del_p.V107fs|ANKDD1A_uc002any.3_Frame_Shift_Del_p.V20fs|ANKDD1A_uc002anz.3_Frame_Shift_Del_p.V20fs|ANKDD1A_uc002aob.3_Intron|ANKDD1A_uc002aoc.3_Non-coding_Transcript|ANKDD1A_uc010bha.3_Frame_Shift_Del_p.V20fs	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	Homo sapiens ankyrin repeat and death domain containing 1A (ANKDD1A), mRNA.	111					signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						AGATCTTGGTAAACTCAGGGG	0.577													---	65	---	---	17	---					
TIMP2	7077	broad.mit.edu	37	17	76867041	76867047	+	Frame_Shift_Del	DEL	GGGGGCC	-	-			TCGA-AL-7173-01A-11D-2136-08	TCGA-AL-7173-10A-01D-2136-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2fd86890-1842-4e9e-9100-f10814f8db6a	d279d1dd-cfd3-4527-8aaf-d880d7862c30	g.chr17:76867041_76867047delGGGGGCC	uc002jwf.3	-	2	575_581	c.273_279delGGCCCCC	c.(271-279)acggcccccfs	p.T91fs	TIMP2_uc002jwe.3_Frame_Shift_Del_p.T14fs|TIMP2_uc010wty.2_Frame_Shift_Del_p.T14fs	NM_003255	NP_003246	P16035	TIMP2_HUMAN	Homo sapiens TIMP metallopeptidase inhibitor 2 (TIMP2), mRNA.	91	NTR.						metal ion binding|metalloendopeptidase inhibitor activity	p.A92V(1)|p.S94fs*43(1)		central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			CTGCCGAGGAGGGGGCCGTGTAGATAA	0.541													---	153	---	---	10	---					
