Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KRTAP5-4	387267	broad.mit.edu	37	11	1643252	1643252	+	Silent	SNP	A	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr11:1643252A>G	uc009ycy.1	-	0	117	c.30T>C	c.(28-30)tgT>tgC	p.C10C	MOB2_uc001ltq.2_Intron	NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	Homo sapiens keratin associated protein 5-4 (KRTAP5-4), mRNA.	104						keratin filament		p.C24C(5)		NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		agccagagccacagcccccac	0.687000														104			15		0	0	0.049695	0	0
REC8	9985	broad.mit.edu	37	14	24646579	24646579	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr14:24646579G>C	uc001wmr.3	+	9	1151	c.724G>C	c.(724-726)Gct>Cct	p.A242P	REC8_uc001wms.3_Missense_Mutation_p.A242P	NM_005132	NP_005123	O95072	REC8_HUMAN	Homo sapiens REC8 homolog (yeast) (REC8), transcript variant 1, mRNA.	243	Glu-rich.|Pro-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(265;0.00839)		CCCACCTCCAGCTCCTGCAGA	0.567000														68			63		0	0	0.139131	0	0
SLC2A2	6514	broad.mit.edu	37	3	170727776	170727776	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr3:170727776G>T	uc003fhe.1	-	3	776	c.467C>A	c.(466-468)gCt>gAt	p.A156D	SLC2A2_uc003fhf.1_Intron|SLC2A2_uc011bpu.1_Missense_Mutation_p.A29D	NM_000340	NP_000331	P11168	GTR2_HUMAN	Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2), mRNA.	156					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GCTTCTTCCAGCAATTATAAG	0.393000														13			3		6.4e-05	7.23478e-05	0.115264	1	0
PLXND1	23129	broad.mit.edu	37	3	129284750	129284750	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr3:129284750C>A	uc003emx.2	-	23	4402	c.4302G>T	c.(4300-4302)aaG>aaT	p.K1434N	PLXND1_uc011blb.1_Missense_Mutation_p.K102N|U7_uc021xdx.1_5'Flank	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	Homo sapiens plexin D1 (PLXND1), mRNA.	1434					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CCGCAAAGTCCTTCTGCTGCT	0.587000														75			11		0.00010058	0.000108962	0.093190	1	0
MRGPRX4	117196	broad.mit.edu	37	11	18195248	18195248	+	Silent	SNP	C	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr11:18195248C>T	uc001mnv.1	+	0	865	c.445C>T	c.(445-447)Ctg>Ttg	p.L149L		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	Homo sapiens MAS-related GPR, member X4 (MRGPRX4), mRNA.	149						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						GCTCTGGGGCCTGTCCCTGCT	0.577000														529			98		0	0	0.139131	0	0
EPDR1	54749	broad.mit.edu	37	7	37960767	37960767	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr7:37960767G>T	uc003tfp.3	+	0	605	c.586G>T	c.(586-588)Gtg>Ttg	p.V196L	EPDR1_uc003tfq.3_Missense_Mutation_p.V76L|EPDR1_uc010kxh.3_5'Flank	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	Homo sapiens ependymin related protein 1 (zebrafish) (EPDR1), transcript variant 1, mRNA.	76					cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	22						CAACCAGCGCGTGCGGGTGCT	0.706000														86			12		6.31663e-08	7.82059e-08	0.132662	1	0
TTN	7273	broad.mit.edu	37	2	179476553	179476553	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr2:179476553G>T	uc021vsy.1	-	216	43004	c.42779C>A	c.(42778-42780)gCt>gAt	p.A14260D	MIR548N_uc021vsx.1_Intron|LOC100506866_uc002ump.2_Intron|TTN_uc021vsz.1_Missense_Mutation_p.A7955D|TTN_uc021vta.1_Missense_Mutation_p.A7888D|TTN_uc021vtb.1_Missense_Mutation_p.A7763D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	15187	Fibronectin type-III 3.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATTTTCAGCCCGAACCTG	0.458000														25			12		9.31168e-06	1.10047e-05	0.105934	1	0
MRC2	9902	broad.mit.edu	37	17	60766323	60766323	+	Splice_Site	SNP	T	C	C			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr17:60766323T>C	uc002jad.3	+	23	3736	c.3334_splice	c.e23+2	p.D1112_splice	MRC2_uc002jae.3_Splice_Site_p.D183_splice|MRC2_uc002jaf.3_Splice_Site_p.R57_splice	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	Homo sapiens mannose receptor, C type 2 (MRC2), mRNA.	1112					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						AGGGCACGGGTATGTGTCACC	0.642000														47			12		0	0	0.105934	0	0
CLSTN2	64084	broad.mit.edu	37	3	140122510	140122510	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr3:140122510C>A	uc003etn.3	+	2	462	c.272C>A	c.(271-273)cCc>cAc	p.P91H	CLSTN2_uc003etm.2_Missense_Mutation_p.P91H	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	Homo sapiens calsyntenin 2 (CLSTN2), mRNA.	91	Cadherin 1.				homophilic cell adhesion	Golgi membrane|endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CAGGAGCTGCCCTTTGAGGCT	0.532000										HNSCC(16;0.037)				193			63		2.69673e-31	3.69027e-31	0.139131	1	0
TAOK3	51347	broad.mit.edu	37	12	118599637	118599637	+	Nonsense_Mutation	SNP	T	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr12:118599637T>A	uc001twx.3	-	17	2390	c.2095A>T	c.(2095-2097)Aga>Tga	p.R699*	TAOK3_uc001twv.3_Nonsense_Mutation_p.R239*|TAOK3_uc001tww.3_Nonsense_Mutation_p.R529*|TAOK3_uc001twy.4_Nonsense_Mutation_p.R699*	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	Homo sapiens TAO kinase 3 (TAOK3), mRNA.	699					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACATGCTTTCTGTGCAGTTCT	0.463000														228			78		0	0	0.139131	0	0
THBD	7056	broad.mit.edu	37	20	23029807	23029807	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr20:23029807G>A	uc002wss.3	-	0	495	c.335C>T	c.(334-336)aCg>aTg	p.T112M	THBD_uc002wst.1_5'Flank|THBD_uc002wsu.1_Missense_Mutation_p.T53M	NM_000361	NP_000352	P07204	TRBM_HUMAN	Homo sapiens thrombomodulin (THBD), mRNA.	112	C-type lectin.				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity			endometrium(2)|large_intestine(3)|ovary(1)|skin(1)	7	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	GTTGTCTCCCGTAACCCACTG	0.716000														8			3		0	0	0.014758	0	0
ALK	238	broad.mit.edu	37	2	29432730	29432730	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr2:29432730C>G	uc002rmy.3	-	24	4710	c.3758G>C	c.(3757-3759)aGa>aCa	p.R1253T	ALK_uc010ymo.2_Missense_Mutation_p.R185T	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), mRNA.	1253	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.R1253G(1)	ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GAGGCAGTTTCTGGCAGCAAT	0.493000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome					77			12		0	0	0.119110	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr10:51093329C>T	uc001jih.3	-	8	1891	c.1750G>A	c.(1750-1752)Gca>Aca	p.A584T	PARG_uc009xoj.3_Missense_Mutation_p.A135T|PARG_uc001jif.3_Missense_Mutation_p.A584T|PARG_uc001jig.3_Missense_Mutation_p.A170T|PARG_uc010qgv.2_Intron|PARG_uc009xoi.3_Intron|PARG_uc010qgw.2_Missense_Mutation_p.A475T|PARG_uc010qgx.2_Missense_Mutation_p.A502T	NM_003631	NP_003622	Q86W56	PARG_HUMAN	Homo sapiens poly (ADP-ribose) glycohydrolase (PARG), mRNA.	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(2)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000														32			3		0	0	0.115264	0	0
ELF4	2000	broad.mit.edu	37	X	129203444	129203444	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chrX:129203444G>A	uc004evd.4	-	7	1403	c.1018C>T	c.(1018-1020)Ccc>Tcc	p.P340S	ELF4_uc004eve.4_Missense_Mutation_p.P340S	NM_001421	NP_001412	Q99607	ELF4_HUMAN	Homo sapiens E74-like factor 4 (ets domain transcription factor) (ELF4), transcript variant 1, mRNA.	340					NK T cell proliferation|natural killer cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	22						TTGCCCTGGGGGGCAGATCTG	0.622000			T	ERG	AML									336			152		0	0	0.139131	0	0
CCDC144A	9720	broad.mit.edu	37	17	16701804	16701804	+	RNA	SNP	C	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr17:16701804C>T	uc010cpj.1	+	17		c.4335C>T			USP32P1_uc010cpk.1_Non-coding_Transcript|USP32P1_uc010vwq.1_Non-coding_Transcript|USP32P1_uc002gqm.2_Non-coding_Transcript			A2RUR9	C144A_HUMAN	Homo sapiens ubiquitin specific peptidase 32 pseudogene 1 (USP32P1), non-coding RNA.																		TGAGCAAAAGCCCATCCTCAC	0.532000														89			7		0	0	0.047766	0	0
UBA52	7311	broad.mit.edu	37	19	18685757	18685757	+	Missense_Mutation	SNP	A	T	T			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr19:18685757A>T	uc002njr.3	+	3	382	c.268A>T	c.(268-270)Aac>Tac	p.N90Y	UBA52_uc002njs.3_Missense_Mutation_p.N90Y|UBA52_uc021uqs.1_5'Flank	NM_001033930	NP_003324	P62987	RL40_HUMAN	Homo sapiens ubiquitin A-52 residue ribosomal protein fusion product 1 (UBA52), transcript variant 1, mRNA.	90					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|JNK cascade|M/G1 transition of mitotic cell cycle|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|S phase of mitotic cell cycle|T cell receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|innate immune response|mRNA metabolic process|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome			endometrium(1)|large_intestine(2)	3						CCAGAAATACAACTGCGACAA	0.612000														88			10		0	0	0.080935	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37962631	37962631	+	Missense_Mutation	SNP	T	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr22:37962631T>G	uc003asz.4	+	1	678	c.275T>G	c.(274-276)gTg>gGg	p.V92G		NM_152243	NP_689449	Q00587	BORG5_HUMAN	Homo sapiens CDC42 effector protein (Rho GTPase binding) 1 (CDC42EP1), mRNA.	92					positive regulation of pseudopodium assembly|regulation of cell shape	Golgi apparatus|actin cytoskeleton|endomembrane system|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					GTGCGGAGGGTGGGGGCGCCC	0.697000														26			8		0	0	0.099896	0	0
PBX2	5089	broad.mit.edu	37	6	32155509	32155509	+	Missense_Mutation	SNP	T	A	A			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr6:32155509T>A	uc003oav.1	-	4	1056	c.785A>T	c.(784-786)tAt>tTt	p.Y262F	PBX2_uc003oaw.3_Missense_Mutation_p.Y262F	NM_002586	NP_002577	P40425	PBX2_HUMAN	Homo sapiens pre-B-cell leukemia homeobox 2 (PBX2), mRNA.	262							transcription factor binding	p.Y262F(6)		endometrium(1)|kidney(1)|lung(9)|ovary(1)|prostate(2)	14						GGAGTAGAAATACTCATTTAG	0.517000														17			3		0	0	0.150653	0	0
CREB3	10488	broad.mit.edu	37	9	35733059	35733059	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr9:35733059A>G	uc003zxv.3	+	1	649	c.196A>G	c.(196-198)Att>Gtt	p.I66V	TLN1_uc003zxt.2_5'Flank|TLN1_uc003zxu.4_5'Flank|CREB3_uc010mla.3_5'UTR	NM_006368	NP_006359	O43889	CREB3_HUMAN	Homo sapiens cAMP responsive element binding protein 3 (CREB3), mRNA.	66	Transcription activation (acidic).				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	Golgi apparatus|cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|integral to membrane|nucleus	CCR1 chemokine receptor binding|DNA binding|cAMP response element binding protein binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|urinary_tract(1)	9	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		GTCGTTGAACATTCTCAGCTC	0.537000														64			59		0	0	0.139131	0	0
SAV1	60485	broad.mit.edu	37	14	51132122	51132129	+	Frame_Shift_Del	DEL	CTAGACTT	-	-			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr14:51132122_51132129delCTAGACTT	uc001wyh.1	-	1	641_648	c.303_310delAAGTCTAG	c.(301-312)agaagtctagcafs	p.R101fs	SAV1_uc021rsy.1_Non-coding_Transcript	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	Homo sapiens salvador homolog 1 (Drosophila) (SAV1), mRNA.	101					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)|kidney(2)|lung(2)|prostate(1)	6	all_epithelial(31;0.000611)|Breast(41;0.0333)					GGGACATCTGCTAGACTTCTGGCAAGAT	0.385													---	17	---	---	13	---					
BRSK1	84446	broad.mit.edu	37	19	55815036	55815036	+	Splice_Site	DEL	C	-	-			TCGA-B3-3926-01A-01D-1252-08	TCGA-B3-3926-11A-01D-1252-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	814dbddd-9703-4c92-b179-428d00b907bf	cc643b5f-d509-4216-928c-5f6ec8b526e2	g.chr19:55815036delC	uc002qkf.3	+	14	1302	c.1175_splice	c.e14-1	p.D392_splice	BRSK1_uc002qkg.3_Splice_Site_p.D376_splice|BRSK1_uc002qkh.3_Splice_Site_p.D71_splice|Mir_324_uc021vbt.1_5'Flank	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	Homo sapiens BR serine/threonine kinase 1 (BRSK1), mRNA.	376					G2/M transition DNA damage checkpoint|establishment of cell polarity|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity	p.R379fs*9(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GTCCCTCAGACCCCCCCCGGA	0.582													---	349	---	---	9	---					
