Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
POMT2	29954	broad.mit.edu	37	14	77765102	77765102	+	Silent	SNP	G	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr14:77765102G>A	uc001xti.2	-	7	1137	c.936C>T	c.(934-936)gaC>gaT	p.D312D	POMT2_uc001xth.1_Silent_p.D10D	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	Homo sapiens protein-O-mannosyltransferase 2 (POMT2), mRNA.	312					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		TGAAGAAACCGTCACCAGGGC	0.532000														25			6		0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53589174	53589174	+	Silent	SNP	C	T	T			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chrX:53589174C>T	uc004dsp.3	-	53	7638	c.7236G>A	c.(7234-7236)gaG>gaA	p.E2412E	HUWE1_uc004dsn.3_Silent_p.E1236E	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	Homo sapiens HECT, UBA and WWE domain containing 1 (HUWE1), mRNA.	2412	Glu-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity	p.E2275D(1)		NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TGTGCTCCTCCTCATCCTCAG	0.498000														35			14		0	0	1	0	0
SLC20A1	6574	broad.mit.edu	37	2	113418129	113418129	+	Silent	SNP	G	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr2:113418129G>A	uc002tib.3	+	8	2312	c.1773G>A	c.(1771-1773)ctG>ctA	p.L591L	SLC20A1_uc002tic.1_Silent_p.L403L	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	Homo sapiens solute carrier family 20 (phosphate transporter), member 1 (SLC20A1), mRNA.	591					phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|skin(1)|urinary_tract(3)	28						GGAAGGATCTGACACCGATCA	0.448000														49			15		0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33132944	33132944	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr19:33132944G>A	uc002ntn.1	-	9	1046	c.890C>T	c.(889-891)tCt>tTt	p.S297F	ANKRD27_uc002nto.1_Missense_Mutation_p.S297F	NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	Homo sapiens ankyrin repeat domain 27 (VPS9 domain) (ANKRD27), mRNA.	297	VPS9.				early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					CTGGCTTGGAGACTGTGTAAT	0.493000														126			46		0	0	1	0	0
TEKT4P2	100132288	broad.mit.edu	37	21	9907358	9907358	+	Silent	SNP	G	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr21:9907358G>A	uc021wgx.1	-	3	503	c.423C>T	c.(421-423)agC>agT	p.S141S	TEKT4P2_uc002zka.2_3'UTR					Homo sapiens tektin 4 pseudogene 2 (TEKT4P2), transcript variant 2, non-coding RNA.																		CCTTCTCCAGGCTCATGTGGA	0.572000														27			7		0	0	1	0	0
HIST1H4B	8366	broad.mit.edu	37	6	26027471	26027471	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr6:26027471G>C	uc003nfr.3	-	0	10	c.10C>G	c.(10-12)Cgc>Ggc	p.R4G		NM_003544	NP_778224	P62805	H4_HUMAN	Homo sapiens histone cluster 1, H4b (HIST1H4B), mRNA.	4					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			large_intestine(4)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	13						CCTTTGCCGCGACCAGACATG	0.512000														78			13		0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30065529	30065529	+	Missense_Mutation	SNP	G	T	T			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr15:30065529G>T	uc001zcr.3	-	2	591	c.116C>A	c.(115-117)tCt>tAt	p.S39Y	TJP1_uc010azl.3_Missense_Mutation_p.S27Y|TJP1_uc001zcq.3_Missense_Mutation_p.S43Y|TJP1_uc001zcs.3_Missense_Mutation_p.S39Y	NM_003257	NP_003248	Q07157	ZO1_HUMAN	Homo sapiens tight junction protein 1 (zona occludens 1) (TJP1), transcript variant 1, mRNA.	39	PDZ 1.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	Golgi apparatus|basolateral plasma membrane|cell-cell adherens junction|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TCGTCCACCAGATATTGCAAT	0.363000														76			18		1.02788e-11	1.05023e-11	1	1	0
EFCAB3	146779	broad.mit.edu	37	17	60484528	60484528	+	Silent	SNP	T	C	C			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr17:60484528T>C	uc010wpc.2	+	9	1049	c.978T>C	c.(976-978)caT>caC	p.H326H	EFCAB3_uc002izu.2_Silent_p.H274H	NM_001144933	NP_001138405	Q8N7B9	EFCB3_HUMAN	Homo sapiens EF-hand calcium binding domain 3 (EFCAB3), transcript variant 1, mRNA.	274							calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			AGCCTTTGCATTTCTTTGAGG	0.358000														61			7		0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32475306	32475306	+	Missense_Mutation	SNP	G	C	C			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr2:32475306G>C	uc002roi.3	-	3	1888	c.1627C>G	c.(1627-1629)Caa>Gaa	p.Q543E	NLRC4_uc021vfq.1_Missense_Mutation_p.Q543E|NLRC4_uc002roj.2_Missense_Mutation_p.Q543E|NLRC4_uc010ezt.2_Intron	NM_001199138	NP_001186067	Q9NPP4	NLRC4_HUMAN	Homo sapiens NLR family, CARD domain containing 4 (NLRC4), transcript variant 2, mRNA.	543					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AGAATTTCTTGCTCAGTGGTG	0.448000														70			20		0	0	1	0	0
SLC16A1	6566	broad.mit.edu	37	1	113460277	113460277	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr1:113460277G>A	uc001ecx.3	-	3	1583	c.751C>T	c.(751-753)Cag>Tag	p.Q251*	SLC16A1_uc001ecy.3_Nonsense_Mutation_p.Q251*|SLC16A1_uc001ecz.3_Nonsense_Mutation_p.Q251*	NM_001166496	NP_003042	P53985	MOT1_HUMAN	Homo sapiens solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (SLC16A1), transcript variant 2, mRNA.	251					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	TCCAGGAACTGATTAATTGTT	0.388000														64			17		0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219510938	219510938	+	Missense_Mutation	SNP	C	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr2:219510938C>A	uc002vin.3	-	6	1843	c.1407G>T	c.(1405-1407)aaG>aaT	p.K469N	ZNF142_uc002vil.3_Missense_Mutation_p.K430N|ZNF142_uc010fvt.3_Missense_Mutation_p.K306N|ZNF142_uc002vim.3_Missense_Mutation_p.K306N	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	Homo sapiens zinc finger protein 142 (ZNF142), mRNA.	469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GGAGGTAGTGCTTCCACTTGG	0.517000														101			28		7.26314e-15	7.58595e-15	1	1	0
DTX2P1-UPK3BP1-PMS2P11	441263	broad.mit.edu	37	7	76631515	76631515	+	RNA	SNP	G	A	A	rs61737189	by1000genomes	TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr7:76631515G>A	uc011kgn.1	+	3		c.656G>A			DTX2P1-UPK3BP1-PMS2P11_uc003ufw.4_Non-coding_Transcript					Homo sapiens DTX2P1-UPK3BP1-PMS2P11 readthrough (non-protein coding) (DTX2P1-UPK3BP1-PMS2P11), non-coding RNA.									p.A7A(1)									TGTCCGCAGCGTCTGGATACA	0.617000														50			13		0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30008820	30008820	+	Silent	SNP	A	G	G			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr15:30008820A>G	uc001zcr.3	-	22	4672	c.4197T>C	c.(4195-4197)tcT>tcC	p.S1399S	TJP1_uc010azl.3_Silent_p.S1387S|TJP1_uc001zcq.3_Silent_p.S1323S|TJP1_uc001zcs.3_Silent_p.S1319S	NM_003257	NP_003248	Q07157	ZO1_HUMAN	Homo sapiens tight junction protein 1 (zona occludens 1) (TJP1), transcript variant 1, mRNA.	1399					cell-cell junction assembly|cellular component disassembly involved in apoptosis	Golgi apparatus|basolateral plasma membrane|cell-cell adherens junction|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CTTACTTTGAAGAATAACTAG	0.368000														45			6		0	0	1	0	0
ATP5A1	498	broad.mit.edu	37	18	43671697	43671697	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr18:43671697A>G	uc002lbr.1	-	2	350	c.260T>C	c.(259-261)cTg>cCg	p.L87P	ATP5A1_uc010dnl.1_Missense_Mutation_p.L37P|ATP5A1_uc002lbs.1_Missense_Mutation_p.L37P|ATP5A1_uc002lbt.1_Missense_Mutation_p.L87P|TRNA_Lys_uc021ujj.1_5'Flank|ATP5A1_uc010xct.1_Missense_Mutation_p.L37P|ATP5A1_uc010dnm.1_Non-coding_Transcript	NM_004046	NP_004037	P25705	ATPA_HUMAN	Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.	87					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|MHC class I protein binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|skin(1)|urinary_tract(1)	22						AACATTCCTCAGCCCATGTAC	0.388000														64			23		0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235247	5235247	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr5:5235247C>G	uc003jdl.3	+	12	2109	c.1971C>G	c.(1969-1971)agC>agG	p.S657R	ADAMTS16_uc003jdk.1_Missense_Mutation_p.S657R|ADAMTS16_uc010itk.1_Non-coding_Transcript	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16), mRNA.	657	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						AGCACAACAGCAGACGATTCA	0.512000														94			14		0	0	1	0	0
TRAV20	28663	broad.mit.edu	37	14	22509285	22509285	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr14:22509285G>A	uc021rpo.1	+	1	289	c.223G>A	c.(223-225)Ggg>Agg	p.G75R	TCRA_uc001wbw.2_Intron|TCRA_uc021rpe.1_Intron|TCR-alpha_uc021rpg.1_Intron|AV2S1A1_uc010aiv.1_Intron|TCRA_uc021rpj.1_Intron|T-Cell_Receptor_V-alpha_region_uc021rpl.1_Intron|TCRA_uc010tmo.2_Intron|TCRA_uc001wco.3_Intron|TCRA_uc010aje.1_Intron|TCRA_uc001wcp.2_Intron|TCRA_uc001wcr.1_Intron|TCRA_uc001wcs.1_Intron|TCRA_uc010ajf.1_Intron|TCRA_uc001wcu.4_Intron|TCRA_uc021rpn.1_Intron|TCRA_uc010tmm.2_Intron|TRAV20_uc021rpp.1_Non-coding_Transcript					Homo sapiens mRNA for T cell receptor alpha variable 20, partial cds, clone: un 136.																		GTATTCAGCTGGGGAAGAAAA	0.458000														31			8		0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54819027	54819027	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr19:54819027G>A	uc002qfe.3	-	5	839	c.719C>T	c.(718-720)gCt>gTt	p.A240V	LILRA5_uc002qff.3_Missense_Mutation_p.A228V|LILRA5_uc010yev.2_Missense_Mutation_p.A240V|LILRA5_uc010yew.2_Missense_Mutation_p.A228V	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 (LILRA5), transcript variant 1, mRNA.	240					innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GAGGTTATCAGCTGCTCCTGA	0.517000														46			11		0	0	1	0	0
CASKIN2	57513	broad.mit.edu	37	17	73498794	73498794	+	Silent	SNP	A	G	G			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr17:73498794A>G	uc002joc.3	-	17	2911	c.2361T>C	c.(2359-2361)acT>acC	p.T787T	CASKIN2_uc010wsc.2_Silent_p.T705T	NM_020753	NP_001136115	Q8WXE0	CSKI2_HUMAN	Homo sapiens CASK interacting protein 2 (CASKIN2), transcript variant 1, mRNA.	787	Pro-rich.					cytoplasm				endometrium(1)|kidney(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGTCTGGGGGAGTGGCAGGGG	0.701000														19			4		0	0	1	0	0
AK054990	0	broad.mit.edu	37	2	131176696	131176696	+	RNA	SNP	C	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr2:131176696C>A	uc002trf.1	-	2		c.474G>T								Homo sapiens cDNA FLJ30428 fis, clone BRACE2008941.																		ATGGCAGGGGCCTGCTGGCTG	0.488000														15			5		8.12818e-05	8.12818e-05	1	1	0
ALDH5A1	7915	broad.mit.edu	37	6	24528249	24528249	+	Missense_Mutation	SNP	G	A	A	rs147358733	byFrequency	TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr6:24528249G>A	uc003nef.3	+	8	1265	c.1237G>A	c.(1237-1239)Gtt>Att	p.V413I	ALDH5A1_uc003neg.3_Missense_Mutation_p.V400I	NM_170740	NP_733936	P51649	SSDH_HUMAN	Homo sapiens aldehyde dehydrogenase 5 family, member A1 (ALDH5A1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	400					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	GAATGATGCCGTTTCTAAAGG	0.413000														50			13		0	0	1	0	0
ZDHHC11	79844	broad.mit.edu	37	5	837562	837562	+	Missense_Mutation	SNP	A	C	C			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr5:837562A>C	uc011cma.1	-	5	1202	c.818T>G	c.(817-819)aTt>aGt	p.I273S	ZDHHC11_uc010itd.1_Non-coding_Transcript	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	Homo sapiens zinc finger, DHHC-type containing 11 (ZDHHC11), mRNA.	273						integral to membrane	acyltransferase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GCGGTTATTAATGAGATACTC	0.493000														56			9		0	0	1	0	0
AK024141	0	broad.mit.edu	37	14	73079085	73079085	+	RNA	SNP	T	C	C			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr14:73079085T>C	uc010arh.1	-	0		c.719A>G								Homo sapiens cDNA FLJ14079 fis, clone HEMBB1002134, weakly similar to ZINC-FINGER PROTEIN NEURO-D4.																		TGCTCTGAGATAATCATTCTA	0.478000														44			11		0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82850838	82850838	+	Nonsense_Mutation	SNP	G	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr5:82850838G>A	uc003kii.3	+	11	10072	c.9716G>A	c.(9715-9717)tGg>tAg	p.W3239*	VCAN_uc003kij.3_Nonsense_Mutation_p.W2252*|VCAN_uc010jau.2_Nonsense_Mutation_p.W1485*|VCAN_uc003kik.3_Nonsense_Mutation_p.W498*|VCAN_uc003kil.3_Nonsense_Mutation_p.W1903*	NM_004385	NP_004376	P13611	CSPG2_HUMAN	Homo sapiens versican (VCAN), transcript variant 1, mRNA.	3239	C-type lectin.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding	p.W3239S(2)		NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GACTTCCGTTGGACTGATGGC	0.443000														51			9		0	0	1	0	0
OR51B6	390058	broad.mit.edu	37	11	5373425	5373425	+	Missense_Mutation	SNP	G	A	A	rs149679624		TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr11:5373425G>A	uc010qzb.2	+	0	688	c.688G>A	c.(688-690)Gga>Aga	p.G230R	HBG1_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc021qcv.1_Intron|OR51B5_uc001maq.2_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	Homo sapiens olfactory receptor, family 51, subfamily B, member 6 (OR51B6), mRNA.	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G230G(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	21		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGTTCTGGAGGAGAAAGGGC	0.418000														103			6		0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32475307	32475307	+	Silent	SNP	C	T	T			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr2:32475307C>T	uc002roi.3	-	3	1887	c.1626G>A	c.(1624-1626)gaG>gaA	p.E542E	NLRC4_uc021vfq.1_Silent_p.E542E|NLRC4_uc002roj.2_Silent_p.E542E|NLRC4_uc010ezt.2_Intron	NM_001199138	NP_001186067	Q9NPP4	NLRC4_HUMAN	Homo sapiens NLR family, CARD domain containing 4 (NLRC4), transcript variant 2, mRNA.	542					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GAATTTCTTGCTCAGTGGTGT	0.448000														70			20		0	0	1	0	0
SNAPIN	23557	broad.mit.edu	37	1	153631989	153631989	+	Missense_Mutation	SNP	C	G	G			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr1:153631989C>G	uc001fcq.3	+	2	331	c.256C>G	c.(256-258)Ctt>Gtt	p.L86V		NM_012437	NP_036569	O95295	SNAPN_HUMAN	Homo sapiens SNAP-associated protein (SNAPIN), mRNA.	86					intracellular protein transport|synaptic vesicle exocytosis	BLOC-1 complex|cell junction|perinuclear region of cytoplasm|synaptic vesicle membrane|synaptosome	SNARE binding			lung(3)	3	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TAAGAAGCTACTTAATGCCCG	0.443000														71			12		0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71231747	71231747	+	Nonsense_Mutation	SNP	T	G	G			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr17:71231747T>G	uc002jjm.4	+	2	320	c.126T>G	c.(124-126)taT>taG	p.Y42*	C17orf80_uc010wqu.1_Nonsense_Mutation_p.Y42*|C17orf80_uc010dfj.3_Nonsense_Mutation_p.Y42*|C17orf80_uc002jjk.1_Nonsense_Mutation_p.Y42*|C17orf80_uc002jjl.4_Nonsense_Mutation_p.Y42*	NM_017941	NP_060411	Q9BSJ5	CQ080_HUMAN	Homo sapiens chromosome 17 open reading frame 80 (C17orf80), transcript variant 1, mRNA.	42						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			AAAAAGTTTATCAGTCCAAGC	0.378000														39			5		0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73905126	73905126	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr6:73905126A>G	uc011dyh.2	+	14	3192	c.2845A>G	c.(2845-2847)Aaa>Gaa	p.K949E	KCNQ5_uc011dyi.2_Missense_Mutation_p.K940E|KCNQ5_uc010kat.3_Missense_Mutation_p.K921E|KCNQ5_uc003pgk.3_Missense_Mutation_p.K930E|KCNQ5_uc011dyj.2_Missense_Mutation_p.K820E|KCNQ5_uc011dyk.2_Missense_Mutation_p.K680E	NM_001160133	NP_001153605	Q9NR82	KCNQ5_HUMAN	Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 5 (KCNQ5), transcript variant 4, mRNA.	930					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GCCTCATGTCAAACTGAAATA	0.408000														86			16		0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71476434	71476434	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr14:71476434A>G	uc001xmo.2	+	8	3159	c.2713A>G	c.(2713-2715)Aat>Gat	p.N905D	PCNX_uc001xmn.4_3'UTR|PCNX_uc010are.1_Missense_Mutation_p.N799D	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	Homo sapiens pecanex homolog (Drosophila) (PCNX), mRNA.	905						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AAGAGCATCCAATATCTGGTA	0.338000														35			3		0	0	1	0	0
RNF13	11342	broad.mit.edu	37	3	149678840	149678840	+	Silent	SNP	C	T	T			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr3:149678840C>T	uc003exn.4	+	10	1879	c.1095C>T	c.(1093-1095)gtC>gtT	p.V365V	RNF13_uc003exp.4_Silent_p.V365V|RNF13_uc010hvh.3_Silent_p.V246V	NM_007282	NP_899237	O43567	RNF13_HUMAN	Homo sapiens ring finger protein 13 (RNF13), transcript variant 1, mRNA.	365					protein autoubiquitination	Golgi membrane|endoplasmic reticulum membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	11		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			ATGTCGTGGTCCAGTTGCAGC	0.358000														62			18		0	0	1	0	0
ATP5F1	515	broad.mit.edu	37	1	112002161	112002161	+	Missense_Mutation	SNP	A	G	G			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr1:112002161A>G	uc009wgf.1	+	6	1053	c.1037A>G	c.(1036-1038)tAt>tGt	p.Y346C	ATP5F1_uc001ebc.3_Missense_Mutation_p.Y199C	NM_001688	NP_001679	P24539	AT5F1_HUMAN	Homo sapiens ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 (ATP5F1), nuclear gene encoding mitochondrial protein, mRNA.	199					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding			breast(1)|cervix(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGCCTGGACTATCATATATCT	0.418000														34			6		0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350134	30350134	+	Missense_Mutation	SNP	A	C	C			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr18:30350134A>C	uc002kxm.1	-	1	809	c.421T>G	c.(421-423)Tac>Gac	p.Y141D		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	Homo sapiens kelch-like 14 (Drosophila) (KLHL14), mRNA.	141	BTB.					cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GTGTAGAGGTACTCGAGCACC	0.642000														187			46		0	0	1	0	0
AK310441	0	broad.mit.edu	37	1	148889643	148889643	+	RNA	SNP	T	C	C	rs4950649	by1000genomes	TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr1:148889643T>C	uc009wkv.1	+	6		c.730T>C								Homo sapiens cDNA, FLJ17483.																		GTAGCAGACATTGGTTTTGAT	0.358000														28			3		0	0	1	0	0
RARS2	57038	broad.mit.edu	37	6	88231239	88231239	+	Missense_Mutation	SNP	A	T	T			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr6:88231239A>T	uc003pme.3	-	11	1038	c.978T>A	c.(976-978)gaT>gaA	p.D326E	RARS2_uc003pmc.3_Missense_Mutation_p.D151E|RARS2_uc003pmf.3_Non-coding_Transcript	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	Homo sapiens arginyl-tRNA synthetase 2, mitochondrial (RARS2), nuclear gene encoding mitochondrial protein, mRNA.	326					arginyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|arginine-tRNA ligase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		CAGCTGCAAGATCTCTGAAAC	0.323000														22			5		0	0	1	0	0
RAN	5901	broad.mit.edu	37	12	131359114	131359114	+	Missense_Mutation	SNP	G	A	A			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr12:131359114G>A	uc001uis.3	+	3	627	c.331G>A	c.(331-333)Gat>Aat	p.D111N	RAN_uc001uir.3_Missense_Mutation_p.D91N|RAN_uc010tbk.2_Missense_Mutation_p.D3N|RAN_uc010tbl.2_Missense_Mutation_p.D3N	NM_006325	NP_006316	P62826	RAN_HUMAN	Homo sapiens RAN, member RAS oncogene family (RAN), mRNA.	91					DNA metabolic process|RNA export from nucleus|androgen receptor signaling pathway|cell division|mitosis|mitotic spindle organization|positive regulation of transcription, DNA-dependent|protein export from nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|melanosome|nuclear pore|nucleoplasm	GTP binding|GTPase activity|androgen receptor binding|chromatin binding|transcription coactivator activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(2)	9	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	Lung NSC(355;7.46e-07)|all_epithelial(31;7.36e-06)		OV - Ovarian serous cystadenocarcinoma(86;9.18e-49)|Epithelial(86;1.42e-45)|all cancers(50;6.28e-40)		CATAATGTTTGATGTAACATC	0.413000														38			8		0	0	1	0	0
S100PBP	64766	broad.mit.edu	37	1	33292114	33292114	+	Frame_Shift_Del	DEL	A	-	-			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr1:33292114delA	uc001bvz.3	+	2	691	c.414delA	c.(412-414)gtafs	p.V138fs	S100PBP_uc001bwa.1_Frame_Shift_Del_p.V138fs|S100PBP_uc001bwb.1_Frame_Shift_Del_p.V138fs|S100PBP_uc001bwc.3_Frame_Shift_Del_p.V138fs|S100PBP_uc001bwd.3_Non-coding_Transcript	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	Homo sapiens S100P binding protein (S100PBP), transcript variant 1, mRNA.	138						nucleus	calcium-dependent protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|stomach(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GACGCTCTGTACTAGAAAAGA	0.413													---	56	---	---	16	---					
EBLN2	55096	broad.mit.edu	37	3	73111503	73111504	+	In_Frame_Ins	INS	-	TGG	TGG	rs143235716	by1000genomes	TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr3:73111503_73111504insTGG	uc003dpj.3	+	0	694_695	c.271_272insTGG	c.(271-273)ttg>tTGGtg	p.91_92insV	PPP4R2_uc003dph.1_Intron|PPP4R2_uc003dpi.1_Intron	NM_018029	NP_060499	Q6P2I7	EBLN2_HUMAN	Homo sapiens endogenous Bornavirus-like nucleoprotein 2 (EBLN2), mRNA.	91							protein binding			endometrium(1)|large_intestine(3)|lung(1)|prostate(1)	6						ACTGGATGCATTGGAACCCCAA	0.490													---	9	---	---	4	---					
MINA	84864	broad.mit.edu	37	3	97673276	97673276	+	Frame_Shift_Del	DEL	C	-	-			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr3:97673276delC	uc003drz.1	-	4	1251	c.745delG	c.(745-747)gccfs	p.A249fs	MINA_uc003dsa.1_Frame_Shift_Del_p.A249fs|MINA_uc003dsb.1_Frame_Shift_Del_p.A249fs|MINA_uc003dsc.1_Frame_Shift_Del_p.A249fs|MINA_uc010hpa.1_Non-coding_Transcript|MINA_uc010hpb.1_Non-coding_Transcript	NM_001042533	NP_694822	Q8IUF8	MINA_HUMAN	Homo sapiens MYC induced nuclear antigen (MINA), transcript variant 1, mRNA.	249	JmjC.				ribosome biogenesis	cytoplasm|nucleolus				breast(2)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)	13						GTAGAGTGGGCCAGCCCCGCA	0.527													---	59	---	---	8	---					
IGFBP1	3484	broad.mit.edu	37	7	45932569	45932569	+	Frame_Shift_Del	DEL	C	-	-			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr7:45932569delC	uc003tnp.3	+	3	952	c.659delC	c.(658-660)tccfs	p.S220fs		NM_000596	NP_000587	P08833	IBP1_HUMAN	Homo sapiens insulin-like growth factor binding protein 1 (IGFBP1), mRNA.	220	Thyroglobulin type-1.					extracellular space	insulin-like growth factor binding			large_intestine(2)|lung(4)	6						TGTGAGACATCCATGGATGGA	0.547													---	109	---	---	11	---					
CYP51A1	1595	broad.mit.edu	37	7	91753101	91753107	+	Frame_Shift_Del	DEL	CTGTCTG	-	-			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr7:91753101_91753107delCTGTCTG	uc003ulm.4	-	5	993_999	c.831_837delCAGACAG	c.(829-837)cgcagacagfs	p.R277fs	CYP51A1_uc011khn.2_Frame_Shift_Del_p.R172fs|CYP51A1_uc003uln.4_Frame_Shift_Del_p.R214fs	NM_000786	NP_001139624	Q16850	CP51A_HUMAN	Homo sapiens cytochrome P450, family 51, subfamily A, polypeptide 1 (CYP51A1), transcript variant 1, mRNA.	271					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	TTTCTTGAGACTGTCTGCGTTTCTGGA	0.338													---	25	---	---	9	---					
TRIP6	7205	broad.mit.edu	37	7	100465513	100465514	+	Frame_Shift_Ins	INS	-	C	C			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr7:100465513_100465514insC	uc003uww.3	+	1	310_311	c.140_141insC	c.(139-141)tgcfs	p.C47fs	TRIP6_uc010lhk.2_Intron|TRIP6_uc022aiv.1_Intron|TRIP6_uc022ait.1_5'UTR|TRIP6_uc022aiu.1_Intron	NM_003302	NP_003293	Q15654	TRIP6_HUMAN	Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), mRNA.	47					focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|liver(1)|lung(5)	14	Lung NSC(181;0.041)|all_lung(186;0.0581)					GTCAATTTTTGCCCCCTTCCAT	0.624													---	251	---	---	81	---					
CEP78	84131	broad.mit.edu	37	9	80866948	80866948	+	Frame_Shift_Del	DEL	A	-	-	rs138501486	by1000genomes	TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr9:80866948delA	uc004aky.4	+	8	1473	c.1197delA	c.(1195-1197)gcafs	p.A399fs	CEP78_uc004akx.2_Frame_Shift_Del_p.A398fs|CEP78_uc010mpp.3_Frame_Shift_Del_p.A399fs	NM_001098802	NP_001092272	Q5JTW2	CEP78_HUMAN	Homo sapiens centrosomal protein 78kDa (CEP78), transcript variant 1, mRNA.	398					G2/M transition of mitotic cell cycle	centrosome|cytosol				breast(1)|cervix(1)|endometrium(5)|large_intestine(7)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	21						CAGAACGTGCAAAAAGACACA	0.418													---	21	---	---	7	---					
GIT2	9815	broad.mit.edu	37	12	110385121	110385127	+	Frame_Shift_Del	DEL	TGGGAGA	-	-			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr12:110385121_110385127delTGGGAGA	uc001tps.2	-	14	1740_1746	c.1575_1581delTCTCCCA	c.(1573-1581)tatctcccafs	p.Y525fs	TCHP_uc001tpo.1_Intron|GIT2_uc001tpq.2_Frame_Shift_Del_p.Y525fs|GIT2_uc001tpv.2_Frame_Shift_Del_p.Y477fs|GIT2_uc001tpu.2_Frame_Shift_Del_p.Y475fs|GIT2_uc001tpt.2_Intron|GIT2_uc010sxu.1_Frame_Shift_Del_p.Y463fs	NM_057169	NP_476510	Q14161	GIT2_HUMAN	Homo sapiens G protein-coupled receptor kinase interacting ArfGAP 2 (GIT2), transcript variant 1, mRNA.	525					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding	p.L526I(2)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						CTTCTCCCATTGGGAGATATGGTTTCT	0.570													---	96	---	---	15	---					
SRCAP	10847	broad.mit.edu	37	16	30736370	30736371	+	Frame_Shift_Ins	INS	-	C	C			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr16:30736370_30736371insC	uc002dze.1	+	24	6010_6011	c.5625_5626insC	c.(5623-5628)cagcccfs	p.Q1875fs	SRCAP_uc002dzf.3_Non-coding_Transcript|SRCAP_uc002dzg.1_Frame_Shift_Ins_p.Q1670fs	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Homo sapiens Snf2-related CREBBP activator protein (SRCAP), mRNA.	1875	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CTCGACGCCAGCCCCCCCCACC	0.569													---	312	---	---	7	---					
ZNF341	84905	broad.mit.edu	37	20	32345059	32345060	+	Frame_Shift_Ins	INS	-	C	C			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr20:32345059_32345060insC	uc002wzy.3	+	5	867_868	c.847_848insC	c.(847-849)accfs	p.T283fs	ZNF341_uc002wzx.3_Frame_Shift_Ins_p.T283fs|ZNF341_uc010geq.3_Frame_Shift_Ins_p.T193fs|ZNF341_uc010ger.3_Non-coding_Transcript	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	Homo sapiens zinc finger protein 341 (ZNF341), mRNA.	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						CGCCCCCATGACCAGCGCCACC	0.629													---	286	---	---	128	---					
NUP50	10762	broad.mit.edu	37	22	45574449	45574449	+	Frame_Shift_Del	DEL	T	-	-			TCGA-B3-8121-01A-21D-2396-08	TCGA-B3-8121-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef96a344-c871-4819-aada-dd93a5c7ca7d	5e9a09f1-d8de-4b72-99a8-ec2dad680376	g.chr22:45574449delT	uc003bfr.3	+	4	1133	c.671delT	c.(670-672)cttfs	p.L224fs	NUP50_uc003bfs.3_Frame_Shift_Del_p.L196fs|NUP50_uc011aqn.2_5'UTR|NUP50_uc003bft.3_Frame_Shift_Del_p.L196fs|NUP50_uc011aqo.1_5'UTR	NM_007172	NP_705931	Q9UKX7	NUP50_HUMAN	Homo sapiens nucleoporin 50kDa (NUP50), transcript variant 2, mRNA.	224	5 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TCTCCTTCCCTTTTTGGCTCA	0.408													---	57	---	---	10	---					
