Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRPM4	54795	broad.mit.edu	37	19	49703680	49703680	+	Silent	SNP	G	T	T			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr19:49703680G>T	uc002pmw.3	+	17	2877	c.2769G>T	c.(2767-2769)gtG>gtT	p.V923V	TRPM4_uc010emu.3_Silent_p.V778V|TRPM4_uc010yak.2_Silent_p.V387V|TRPM4_uc002pmx.3_Silent_p.V749V|TRPM4_uc010emv.3_Silent_p.V808V|TRPM4_uc010yal.2_Silent_p.V569V|TRPM4_uc002pmy.3_Silent_p.V265V	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	Homo sapiens transient receptor potential cation channel, subfamily M, member 4 (TRPM4), transcript variant 1, mRNA.	923					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	Golgi apparatus|endoplasmic reticulum|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TCGTCATCGTGAGCAAGATGG	0.612000														26			10		0.000442599	0.000479483	0.058154	1	0
KRTAP10-3	386682	broad.mit.edu	37	21	45978127	45978127	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr21:45978127C>T	uc002zfj.1	-	0	517	c.472G>A	c.(472-474)Gtg>Atg	p.V158M	TSPEAR_uc002zfe.1_Intron|TSPEAR_uc010gpv.1_Intron	NM_198696	NP_941969	P60369	KR103_HUMAN	Homo sapiens keratin associated protein 10-3 (KRTAP10-3), mRNA.	158	18 X 5 AA repeats of C-C-X(3).					keratin filament				kidney(1)|lung(4)|prostate(1)|skin(1)	7						AGGAGGGACACGGAGGAGGAG	0.692000														91			26		0	0	0.034045	0	0
TPCN1	53373	broad.mit.edu	37	12	113704162	113704162	+	Splice_Site	SNP	G	T	T			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr12:113704162G>T	uc001tux.3	+	5	804	c.630_splice	c.e5+1	p.Y210_splice	TPCN1_uc001tuw.3_Splice_Site_p.Y138_splice|TPCN1_uc010syt.1_Splice_Site_p.Y70_splice	NM_001143819	NP_060371	Q9ULQ1	TPC1_HUMAN	Homo sapiens two pore segment channel 1 (TPCN1), transcript variant 1, mRNA.	138						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						TGGCATCTATGTGAGCGCACA	0.622000														275			63		1.25706e-45	1.63418e-45	0.048971	1	0
KHDRBS1	10657	broad.mit.edu	37	1	32508212	32508212	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr1:32508212A>G	uc001bub.3	+	8	1425	c.1319A>G	c.(1318-1320)tAt>tGt	p.Y440C	KHDRBS1_uc001bua.1_Missense_Mutation_p.Y401C|KHDRBS1_uc001buc.1_Non-coding_Transcript	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	Homo sapiens KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1), mRNA.	440					G2/M transition of mitotic cell cycle|cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity	p.P439Q(1)		endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GAGCACCCATATGGACGTTAT	0.483000														41			12		0	0	0.093190	0	0
ANKRD19P	138649	broad.mit.edu	37	9	95599082	95599082	+	RNA	SNP	C	T	T	rs10156497	by1000genomes	TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr9:95599082C>T	uc004ass.2	+	8		c.1166C>T			ANKRD19P_uc004asr.4_Non-coding_Transcript					Homo sapiens ankyrin repeat domain 19, pseudogene (ANKRD19P), non-coding RNA.																		CAGGGATTCACGGGCGCACAC	0.398000														30			3		0	0	0.009096	0	0
SLFN11	91607	broad.mit.edu	37	17	33679780	33679780	+	Silent	SNP	G	A	A			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr17:33679780G>A	uc002hjg.4	-	4	2548	c.2301C>T	c.(2299-2301)gcC>gcT	p.A767A	SLFN11_uc010ctr.3_Silent_p.A767A|SLFN11_uc010ctp.3_Silent_p.A767A|SLFN11_uc010ctq.3_Silent_p.A767A|SLFN11_uc002hjh.4_Silent_p.A767A	NM_152270	NP_689483	Q7Z7L1	SLN11_HUMAN	Homo sapiens schlafen family member 11 (SLFN11), transcript variant 5, mRNA.	767						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGGACCATTCGGCTTCAGGAA	0.443000														63			18		0	0	0.038395	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204379183	204379183	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr1:204379183C>A	uc001hav.4	-	0	1762	c.1357G>T	c.(1357-1359)Gag>Tag	p.E453*		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 15B (PPP1R15B), mRNA.	453					regulation of translation					breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CCATCATCCTCAGCTTCCTCA	0.448000														172			49		6.14515e-18	7.73099e-18	0.048971	1	0
ABCC10	89845	broad.mit.edu	37	6	43412937	43412937	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr6:43412937C>T	uc003ouy.1	+	13	3130	c.2915C>T	c.(2914-2916)gCg>gTg	p.A972V	ABCC10_uc003ouz.1_Missense_Mutation_p.A944V|ABCC10_uc010jyo.1_Missense_Mutation_p.A78V	NM_001198934	NP_001185863	Q5T3U5	MRP7_HUMAN	Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (ABCC10), transcript variant MRP7, mRNA.	972	ABC transmembrane type-1 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			ACCGTGTATGCGACCATTGCT	0.607000														75			4		0	0	0.009096	0	0
TTLL7	79739	broad.mit.edu	37	1	84348653	84348653	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr1:84348653T>C	uc001djc.3	-	19	2932	c.2536A>G	c.(2536-2538)Aat>Gat	p.N846D	TTLL7_uc001djb.3_Non-coding_Transcript|TTLL7_uc001djd.3_Non-coding_Transcript|TTLL7_uc001dje.3_Non-coding_Transcript|TTLL7_uc001djf.3_Non-coding_Transcript|TTLL7_uc001djg.3_Non-coding_Transcript	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	Homo sapiens tubulin tyrosine ligase-like family, member 7 (TTLL7), mRNA.	846					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TACCTGGAATTACCCCAGTCA	0.398000														119			17		0	0	0.049695	0	0
IRS4	8471	broad.mit.edu	37	X	107978243	107978243	+	Silent	SNP	C	T	T			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chrX:107978243C>T	uc004eoc.2	-	0	1365	c.1332G>A	c.(1330-1332)cgG>cgA	p.R444R		NM_003604	NP_003595	O14654	IRS4_HUMAN	Homo sapiens insulin receptor substrate 4 (IRS4), mRNA.	444						plasma membrane	SH3/SH2 adaptor activity|insulin receptor binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CTGCAGGGTGCCGGGGACGTG	0.617000														163			5		0	0	0.014758	0	0
ANKRD11	29123	broad.mit.edu	37	16	89345492	89345492	+	Silent	SNP	G	A	A			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr16:89345492G>A	uc002fmx.1	-	8	7919	c.7458C>T	c.(7456-7458)ctC>ctT	p.L2486L	ANKRD11_uc002fmy.1_Silent_p.L2486L|ANKRD11_uc002fnc.1_Silent_p.L2486L|ANKRD11_uc002fna.1_Silent_p.L151L|ANKRD11_uc002fnb.1_Silent_p.L2443L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	Homo sapiens ankyrin repeat domain 11 (ANKRD11), transcript variant 2, mRNA.	2486						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CGGGGATGTGGAGCTTGCTGA	0.657000														29			6		0	0	0.058154	0	0
PTPRM	5797	broad.mit.edu	37	18	8379245	8379245	+	Silent	SNP	G	A	A			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr18:8379245G>A	uc002knn.4	+	25	4157	c.3654G>A	c.(3652-3654)cgG>cgA	p.R1218R	PTPRM_uc010dkv.3_Silent_p.R1231R|PTPRM_uc010wzl.2_Silent_p.R1005R	NM_002845	NP_002836	P28827	PTPRM_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, M (PTPRM), transcript variant 2, mRNA.	1218	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				AGAAAAACCGGTGCATGGACA	0.562000														77			22		0	0	0.055883	0	0
PRTN3	5657	broad.mit.edu	37	19	841048	841048	+	Silent	SNP	C	T	T			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr19:841048C>T	uc002lqa.1	+	0	64	c.40C>T	c.(40-42)Ctg>Ttg	p.L14L	PRTN3_uc021umb.1_5'Flank	NM_002777	NP_002768	P24158	PRTN3_HUMAN	Homo sapiens proteinase 3 (PRTN3), mRNA.	14					collagen catabolic process|positive regulation of cell proliferation|proteolysis		protein binding|serine-type endopeptidase activity			lung(1)|ovary(2)|urinary_tract(1)	4		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGTCCGTGCTGCTGGCCTT	0.657000														29			8		0	0	0.069234	0	0
MTBP	27085	broad.mit.edu	37	8	121518998	121518998	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr8:121518998C>T	uc003ypc.1	+	15	1825	c.1780C>T	c.(1780-1782)Cct>Tct	p.P594S		NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Homo sapiens Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa (MTBP), mRNA.	594	Interaction with MDM2 (By similarity).				cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			CAAAGAGGGTCCTCGGGACTC	0.398000														68			6		0	0	0.021553	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121681010	121681010	+	Silent	SNP	G	A	A			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr7:121681010G>A	uc003vjy.3	+	20	6173	c.5778G>A	c.(5776-5778)gtG>gtA	p.V1926V	PTPRZ1_uc011knt.2_Silent_p.V1066V|PTPRZ1_uc003vjz.3_Silent_p.V1059V	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1), transcript variant 1, mRNA.	1926	Tyrosine-protein phosphatase 1.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GCCATGCAGTGGGGCCTGTTG	0.498000														66			13		0	0	0.024245	0	0
CFH	3075	broad.mit.edu	37	1	196706023	196706023	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr1:196706023A>T	uc001gtj.4	+	15	2723	c.2483A>T	c.(2482-2484)aAt>aTt	p.N828I	CFH_uc021pgt.1_Intron	NM_000186	NP_000177	P08603	CFAH_HUMAN	Homo sapiens complement factor H (CFH), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	828	Sushi 14.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						ACCACACTGAATTATCGGGAT	0.333000														45			5		0	0	0.021553	0	0
OR5T2	219464	broad.mit.edu	37	11	56000140	56000140	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr11:56000140G>T	uc010rjc.2	-	0	522	c.522C>A	c.(520-522)agC>agA	p.S174R		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily T, member 2 (OR5T2), mRNA.	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S174I(2)		endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TGGGTGACATGCTCACTGAAT	0.433000														148			45		1.15505e-17	1.40771e-17	0.111260	1	0
GTSE1	51512	broad.mit.edu	37	22	46724721	46724721	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr22:46724721A>C	uc011aqy.2	+	9	2073	c.1861A>C	c.(1861-1863)Aaa>Caa	p.K621Q	GTSE1_uc011aqz.2_Missense_Mutation_p.K468Q|GTSE1_uc003bhm.1_Missense_Mutation_p.K246Q|GTSE1_uc003bhn.3_5'Flank|BC069212_uc011ara.2_5'Flank|BC069212_uc003bho.4_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	Homo sapiens G-2 and S-phase expressed 1 (GTSE1), mRNA.	602					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		TACTTTCTCCAAAAGTACTGC	0.567000														166			38		0	0	0.080422	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21030825	21030825	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr12:21030825G>C	uc010sil.2	+	7	1155	c.1090G>C	c.(1090-1092)Gag>Cag	p.E364Q	SLCO1B3_uc001rek.3_Missense_Mutation_p.E364Q|SLCO1B3_uc001rel.3_Missense_Mutation_p.E364Q|SLCO1B3_uc010sim.2_Intron			Q9NPD5	SO1B3_HUMAN	Homo sapiens solute carrier organic anion transporter family, member 1B3 (SLCO1B3), mRNA.	364					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TAAATATATGGAGCAACAGTA	0.353000														142			4		0	0	0.009096	0	0
MST1P9	11223	broad.mit.edu	37	1	17086856	17086856	+	Silent	SNP	G	A	A			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr1:17086856G>A	uc010ock.2	-	3	468	c.468C>T	c.(466-468)tgC>tgT	p.C156C	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.4_5'Flank					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 9 (MST1P9), non-coding RNA.											breast(1)|endometrium(11)|kidney(9)|large_intestine(1)|lung(5)|pancreas(1)|prostate(4)|stomach(1)|urinary_tract(1)	34						TACCCACCCGGCAGGATTTGA	0.632000														35			6		0	0	0.038147	0	0
DIS3L2	129563	broad.mit.edu	37	2	233075106	233075106	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr2:233075106C>G	uc010fxz.3	+	9	1471	c.1195C>G	c.(1195-1197)Ctc>Gtc	p.L399V	DIS3L2_uc002vsm.4_Non-coding_Transcript|DIS3L2_uc002vso.3_Non-coding_Transcript	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	Homo sapiens DIS3 mitotic control homolog (S. cerevisiae)-like 2 (DIS3L2), mRNA.	399							RNA binding|exonuclease activity|ribonuclease activity	p.L399H(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CTGCAAGCCACTCGCTGACGG	0.512000														40			7		0	0	0.038147	0	0
CAMK1D	57118	broad.mit.edu	37	10	12811756	12811756	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr10:12811756G>A	uc001ilo.3	+	4	758	c.523G>A	c.(523-525)Gga>Aga	p.G175R	CAMK1D_uc001iln.3_Missense_Mutation_p.G175R	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	Homo sapiens calcium/calmodulin-dependent protein kinase ID (CAMK1D), transcript variant 2, mRNA.	175	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		GGAGGGCAAAGGAGATGTGAT	0.458000														65			15		0	0	0.028581	0	0
HNRNPL	3191	broad.mit.edu	37	19	39336576	39336576	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr19:39336576G>C	uc021uuh.1	-	2	552	c.541C>G	c.(541-543)Cgc>Ggc	p.R181G	HNRNPL_uc021uui.1_Missense_Mutation_p.R48G|HNRNPL_uc010xun.2_5'Flank	NM_001533	NP_001005335	P14866	HNRPL_HUMAN	Homo sapiens heterogeneous nuclear ribonucleoprotein L (HNRNPL), transcript variant 1, mRNA.	181					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	RNA binding|nucleotide binding|protein binding|transcription regulatory region DNA binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TCCCCAGGGCGGGAGATCTTC	0.542000														148			24		0	0	0.034045	0	0
AMIGO3	386724	broad.mit.edu	37	3	49755505	49755505	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr3:49755505T>C	uc003cxj.3	-	0	1734	c.1394A>G	c.(1393-1395)aAt>aGt	p.N465S	RNF123_uc003cxh.3_Intron|RNF123_uc003cxi.3_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	Homo sapiens adhesion molecule with Ig-like domain 3 (AMIGO3), mRNA.	465					heterophilic cell-cell adhesion	integral to membrane				endometrium(1)|pancreas(1)|prostate(2)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CACGCGGCCATTGAGGCCCCT	0.632000														87			14		0	0	0.038395	0	0
CDH10	1008	broad.mit.edu	37	5	24492973	24492973	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr5:24492973delA	uc003jgr.2	-	9	2083	c.1577delT	c.(1576-1578)ttcfs	p.F526fs	CDH10_uc011cnu.2_Non-coding_Transcript	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	Homo sapiens cadherin 10, type 2 (T2-cadherin) (CDH10), mRNA.	526	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.F525V(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGCTAAACTGAAAAAAAATTT	0.313										HNSCC(23;0.051)			---	350	---	---	7	---					
C11orf9	745	broad.mit.edu	37	11	61544792	61544798	+	Frame_Shift_Del	DEL	GGTGCCC	-	-			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr11:61544792_61544798delGGTGCCC	uc001nsc.1	+	11	1743_1749	c.1647_1653delGGTGCCC	c.(1645-1653)caggtgcccfs	p.Q549fs	C11orf9_uc001nse.1_Frame_Shift_Del_p.Q540fs|C11orf9_uc010rll.1_5'Flank	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	Homo sapiens chromosome 11 open reading frame 9 (C11orf9), transcript variant 2, mRNA.	549					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|prostate(1)	29						AGCGGGCACAGGTGCCCGACACCGTCT	0.647													---	57	---	---	7	---					
PLAC4	191585	broad.mit.edu	37	21	42551272	42551272	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BQ-5888-01A-11D-1589-08	TCGA-BQ-5888-11A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31e068e4-adc9-4148-b785-8deb4ef1637a	2d3ada40-7a55-492a-9f70-0cfe97cc66ea	g.chr21:42551272delC	uc002yyz.3	-	0	5895	c.284delG	c.(283-285)ggafs	p.G95fs	BACE2_uc002yyw.3_Intron|BACE2_uc002yyx.3_Intron|BACE2_uc002yyy.3_Intron	NM_182832	NP_878252	Q8WY50	PLAC4_HUMAN	Homo sapiens placenta-specific 4 (PLAC4), mRNA.	95													Prostate(19;2.29e-06)				gtgagggtatccagggtgagt	0.602													---	4	---	---	4	---					
