Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RPS14	6208	broad.mit.edu	37	5	149827271	149827271	+	Missense_Mutation	SNP	T	C	C			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr5:149827271T>C	uc003lsh.3	-	1	299	c.26A>G	c.(25-27)aAg>aGg	p.K9R	RPS14_uc003lsi.3_Missense_Mutation_p.K9R|RPS14_uc003lsj.3_Missense_Mutation_p.K9R	NM_001025071	NP_005608	P62263	RS14_HUMAN	Homo sapiens ribosomal protein S14 (RPS14), transcript variant 1, mRNA.	9					endocrine pancreas development|erythrocyte differentiation|maturation of SSU-rRNA|negative regulation of transcription from RNA polymerase II promoter|ribosomal small subunit assembly|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA 5'-UTR binding|protein binding|structural constituent of ribosome|translation regulator activity			central_nervous_system(1)|lung(1)|skin(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCTTCCTTCTTTTCCTTCCC	0.443000														67			57		0	0	0.014410	0	0
NIPSNAP3B	55335	broad.mit.edu	37	9	107531256	107531256	+	Silent	SNP	T	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr9:107531256T>A	uc004bci.3	+	2	455	c.384T>A	c.(382-384)atT>atA	p.I128I	NIPSNAP3B_uc011lvu.1_Intron|NIPSNAP3B_uc004bcj.1_Non-coding_Transcript	NM_018376	NP_060846	Q9BS92	NPS3B_HUMAN	Homo sapiens nipsnap homolog 3B (C. elegans) (NIPSNAP3B), mRNA.	128										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	11						AGACGGAAATTACTTACCTGA	0.383000														31			32		0	0	0.003271	0	0
YWHAH	7533	broad.mit.edu	37	22	32352660	32352660	+	Silent	SNP	C	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr22:32352660C>T	uc003alz.3	+	1	863	c.622C>T	c.(622-624)Ctg>Ttg	p.L208L	YWHAH_uc003ama.3_Silent_p.L138L|YWHAH_uc010gwm.3_Silent_p.L195L	NM_003405	NP_003396	Q04917	1433F_HUMAN	Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (YWHAH), mRNA.	208					glucocorticoid catabolic process|glucocorticoid receptor signaling pathway|intracellular protein transport|negative regulation of dendrite morphogenesis|positive regulation of transcription, DNA-dependent|regulation of synaptic plasticity	cytoplasm	enzyme binding|glucocorticoid receptor binding|insulin-like growth factor receptor binding|protein domain specific binding			breast(1)|central_nervous_system(1)|large_intestine(1)|upper_aerodigestive_tract(1)	4						CATAGCTGAGCTGGACACACT	0.527000														11			15		0	0	0.004990	0	0
ZDHHC18	84243	broad.mit.edu	37	1	27176925	27176925	+	Silent	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr1:27176925G>A	uc001bnb.3	+	3	875	c.780G>A	c.(778-780)acG>acA	p.T260T	BC016143_uc021ojq.1_Intron|ZDHHC18_uc010ofh.1_Silent_p.T125T	NM_032283	NP_115659	Q9NUE0	ZDH18_HUMAN	Homo sapiens zinc finger, DHHC-type containing 18 (ZDHHC18), mRNA.	260						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(2)	3		all_cancers(24;5.82e-22)|all_epithelial(13;9.91e-20)|Colorectal(325;0.000147)|Breast(348;0.000706)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;5.71e-53)|Epithelial(14;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(117;1.53e-29)|Colorectal(126;1.9e-09)|COAD - Colon adenocarcinoma(152;4.2e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000548)|STAD - Stomach adenocarcinoma(196;0.00065)|KIRC - Kidney renal clear cell carcinoma(1967;0.000779)|GBM - Glioblastoma multiforme(114;0.0265)|READ - Rectum adenocarcinoma(331;0.0455)|Lung(427;0.163)|LUSC - Lung squamous cell carcinoma(448;0.237)		CCCACCTGACGTTGCGTGAGT	0.567000														81			63		0	0	0.014410	0	0
NBPF10	100132406	broad.mit.edu	37	1	145360624	145360624	+	Silent	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr1:145360624G>A	uc021oul.1	+	73	9284	c.9249G>A	c.(9247-9249)tcG>tcA	p.S3083S	NBPF10_uc010oye.2_Intron|NBPF10_uc010oyi.2_Intron|NBPF10_uc010oyj.2_Intron|NBPF10_uc010oyl.2_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc021ouq.1_Non-coding_Transcript	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 10 (NBPF10), mRNA.	3083								p.S3083S(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GATGTTATTCGACTCCTTCAG	0.478000														14			3		0	0	0.001984	0	0
SEC14L4	284904	broad.mit.edu	37	22	30891293	30891293	+	Missense_Mutation	SNP	C	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr22:30891293C>T	uc003aid.2	-	4	471	c.371G>A	c.(370-372)cGc>cAc	p.R124H	SEC14L4_uc011akz.1_Missense_Mutation_p.R124H|SEC14L4_uc003aie.2_Missense_Mutation_p.R109H|SEC14L4_uc003aif.2_Missense_Mutation_p.R70H	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	Homo sapiens SEC14-like 4 (S. cerevisiae) (SEC14L4), transcript variant 1, mRNA.	124	CRAL-TRIO.		R -> G (in dbSNP:rs9606739).			integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	GACTTTGATGCGCTTCCGGAT	0.572000														20			15		0	0	0.002450	0	0
CEP290	80184	broad.mit.edu	37	12	88479916	88479916	+	Missense_Mutation	SNP	C	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr12:88479916C>A	uc001tar.3	-	33	4681	c.4337G>T	c.(4336-4338)aGt>aTt	p.S1446I	CEP290_uc001taq.3_Missense_Mutation_p.S506I	NM_025114	NP_079390	O15078	CE290_HUMAN	Homo sapiens centrosomal protein 290kDa (CEP290), mRNA.	1446					G2/M transition of mitotic cell cycle|cilium assembly|eye photoreceptor cell development|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						AAGGGGCAAACTAGGGTCAGG	0.353000														81			3		0.00909568	0.00955817	0.009096	1	0
RBBP5	5929	broad.mit.edu	37	1	205064022	205064022	+	Missense_Mutation	SNP	C	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr1:205064022C>T	uc010prd.2	-	11	1953	c.1672G>A	c.(1672-1674)Gaa>Aaa	p.E558K	RBBP5_uc010pre.2_Missense_Mutation_p.E396K|RBBP5_uc001hbu.2_Missense_Mutation_p.E523K|RBBP5_uc001hbv.2_Intron	NM_005057	NP_005048	Q15291	RBBP5_HUMAN	Homo sapiens retinoblastoma binding protein 5 (RBBP5), transcript variant 1, mRNA.	523					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			cervix(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	27	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			TGGCTGAGTTCCGCCTGCACT	0.473000														67			52		0	0	0.014410	0	0
PRPF4B	8899	broad.mit.edu	37	6	4047415	4047415	+	Missense_Mutation	SNP	C	G	G			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr6:4047415C>G	uc003mvv.3	+	6	1959	c.1868C>G	c.(1867-1869)tCt>tGt	p.S623C	PRPF4B_uc003mvw.3_Non-coding_Transcript|PRPF4B_uc011dhv.1_Non-coding_Transcript	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	Homo sapiens PRP4 pre-mRNA processing factor 4 homolog B (yeast) (PRPF4B), mRNA.	623						catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TAAGGTTCATCTCAGAAGAAG	0.284000														113			51		0	0	0.014410	0	0
CDKN2B	1030	broad.mit.edu	37	9	22006244	22006244	+	Silent	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr9:22006244G>A	uc003zpo.3	-	1	519	c.159C>T	c.(157-159)gtC>gtT	p.V53V	MTAP_uc003zpi.1_Intron|MTAP_uc010miw.1_Intron|CDKN2B-AS1_uc022bed.1_Intron|CDKN2B-AS1_uc022bee.1_Intron|CDKN2B-AS1_uc010mix.1_Intron|CDKN2B-AS1_uc022bef.1_Intron|MTAP_uc003zpm.3_Intron|MTAP_uc022bek.1_Intron|CDKN2B-AS1_uc022beg.1_Intron|CDKN2B-AS1_uc022beh.1_Intron|CDKN2B-AS1_uc022bei.1_Intron|CDKN2B-AS1_uc022bej.1_Intron|CDKN2B-AS1_uc022bel.1_Intron|CDKN2B-AS1_uc022bem.1_Intron|CDKN2B-AS1_uc022ben.1_Intron|CDKN2B_uc003zpn.3_3'UTR	NM_004936	NP_004927	P42772	CDN2B_HUMAN	Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mRNA.	53					G1 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|cell cycle arrest|cellular response to nutrient|megakaryocyte differentiation|mitotic cell cycle G1/S transition checkpoint|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0(1)|p.0?(1)		lung(2)	2		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;1.31e-280)|Lung NSC(2;2.28e-131)|all_lung(2;2.11e-123)|Glioma(2;5.66e-57)|all_neural(2;3.05e-50)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;8.01e-33)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00369)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;3.29e-71)|Epithelial(2;9.08e-60)|LUSC - Lung squamous cell carcinoma(2;5.8e-46)|LUAD - Lung adenocarcinoma(2;1.43e-25)|BRCA - Breast invasive adenocarcinoma(2;5.37e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;6.92e-07)|KIRC - Kidney renal clear cell carcinoma(2;8.63e-07)|OV - Ovarian serous cystadenocarcinoma(39;0.014)|COAD - Colon adenocarcinoma(8;0.143)		CCATCATCATGACCTGCCAGA	0.647000														12			7		0	0	0.003080	0	0
SUPT6H	6830	broad.mit.edu	37	17	27002076	27002076	+	Missense_Mutation	SNP	T	C	C			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr17:27002076T>C	uc010crt.3	+	5	626	c.434T>C	c.(433-435)aTt>aCt	p.I145T	SUPT6H_uc002hby.3_Missense_Mutation_p.I145T	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	Homo sapiens suppressor of Ty 6 homolog (S. cerevisiae) (SUPT6H), mRNA.	145	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	RNA binding|hydrolase activity, acting on ester bonds|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					AAAGAAGCTATTGCGGAAGAA	0.527000														44			21		0	0	0.012319	0	0
GALNT4	8693	broad.mit.edu	37	12	89918277	89918277	+	Missense_Mutation	SNP	A	C	C			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr12:89918277A>C	uc001tbd.3	-	0	307	c.50T>G	c.(49-51)tTt>tGt	p.F17C	GALNT4_uc001tba.3_Intron|GALNT4_uc001tbb.3_Intron|GALNT4_uc010sun.2_Intron|GALNT4_uc001tbc.3_Intron|GALNT4_uc001tbe.3_Intron|GALNT4_uc010suo.2_Intron	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) (GALNT4), mRNA.	17					carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(4)|kidney(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)	14						CACTGTTAAAAACGCCAGCAG	0.617000											OREG0022018	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		26			17		0	0	0.010504	0	0
MAU2	23383	broad.mit.edu	37	19	19452209	19452209	+	Missense_Mutation	SNP	C	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr19:19452209C>T	uc002nmk.4	+	6	767	c.728C>T	c.(727-729)gCc>gTc	p.A243V	MAU2_uc002nml.4_5'Flank	NM_015329	NP_056144	Q9Y6X3	SCC4_HUMAN	Homo sapiens MAU2 chromatid cohesion factor homolog (C. elegans) (MAU2), mRNA.	243					cell division|maintenance of mitotic sister chromatid cohesion	SMC loading complex|chromatin|nucleoplasm	protein N-terminus binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	18						TATCTGGATGCCGGGCAGGTG	0.622000														42			3		0	0	0.009096	0	0
UBIAD1	29914	broad.mit.edu	37	1	11346095	11346095	+	Silent	SNP	G	C	C			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr1:11346095G>C	uc001asg.3	+	1	1258	c.924G>C	c.(922-924)ctG>ctC	p.L308L		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	Homo sapiens UbiA prenyltransferase domain containing 1 (UBIAD1), mRNA.	308					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		TCAACAAACTGCCCCAGAGGA	0.547000														82			52		0	0	0.014410	0	0
SLC7A1	6541	broad.mit.edu	37	13	30091728	30091728	+	Missense_Mutation	SNP	T	C	C			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr13:30091728T>C	uc001uso.3	-	9	1879	c.1492A>G	c.(1492-1494)Att>Gtt	p.I498V		NM_003045	NP_003036	P30825	CTR1_HUMAN	Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 (SLC7A1), mRNA.	498					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|stomach(1)|urinary_tract(2)	24		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CTGGTTGAAATGTTCACAATT	0.498000														183			75		0	0	0.014410	0	0
LOC728024	728024	broad.mit.edu	37	8	37605333	37605333	+	Missense_Mutation	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr8:37605333G>A	uc010lvx.2	-	0	232	c.190C>T	c.(190-192)Cat>Tat	p.H64Y	ERLIN2_uc003xke.4_Intron					Homo sapiens chromosome X open reading frame 56 pseudogene (LOC728024), non-coding RNA.																		TTATGGGCATGTTTGGCAGCA	0.498000														72			46		0	0	0.014410	0	0
GJD2	57369	broad.mit.edu	37	15	35044907	35044907	+	Silent	SNP	C	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr15:35044907C>T	uc001zis.1	-	1	738	c.738G>A	c.(736-738)cgG>cgA	p.R246R	AK092087_uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	Homo sapiens gap junction protein, delta 2, 36kDa (GJD2), mRNA.	246					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	19		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		TCTCAGTTGGCCGGGACACAT	0.493000														48			3		0	0	0.009096	0	0
LGI4	163175	broad.mit.edu	37	19	35622732	35622732	+	Missense_Mutation	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr19:35622732G>A	uc002nxx.2	-	4	1013	c.419C>T	c.(418-420)cCc>cTc	p.P140L	LGI4_uc002nxy.1_5'UTR|LGI4_uc002nxz.1_5'UTR|LGI4_uc002nya.3_Missense_Mutation_p.P140L	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	Homo sapiens leucine-rich repeat LGI family, member 4 (LGI4), mRNA.	140						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CAGGAATCTGGGGAGGGTCTC	0.607000														2			3		0	0	0.009096	0	0
ATG7	10533	broad.mit.edu	37	3	11356947	11356947	+	Missense_Mutation	SNP	T	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr3:11356947T>A	uc003bwc.3	+	6	775	c.658T>A	c.(658-660)Ttc>Atc	p.F220I	ATG7_uc003bwd.3_Missense_Mutation_p.F220I|ATG7_uc011aum.2_Missense_Mutation_p.F181I	NM_006395	NP_006386	O95352	ATG7_HUMAN	Homo sapiens ATG7 autophagy related 7 homolog (S. cerevisiae) (ATG7), transcript variant 1, mRNA.	220					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	34						CAGTGATTTCTTCCAAGGTCA	0.348000														35			21		0	0	0.003330	0	0
ETS1	2113	broad.mit.edu	37	11	128360461	128360461	+	Nonsense_Mutation	SNP	A	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr11:128360461A>T	uc010sbs.1	-	1	409	c.93T>A	c.(91-93)tgT>tgA	p.C31*	ETS1_uc001qej.2_Nonsense_Mutation_p.C75*|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Nonsense_Mutation_p.C31*	NM_005238	NP_005229	P14921	ETS1_HUMAN	Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (ETS1), transcript variant 2, mRNA.	31					PML body organization|cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|pleura(1)|prostate(1)|upper_aerodigestive_tract(3)	35	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		GGACATCTGCACATTCCATAT	0.363000														37			19		0	0	0.012319	0	0
OR4A16	81327	broad.mit.edu	37	11	55110797	55110797	+	Missense_Mutation	SNP	C	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr11:55110797C>T	uc010rie.2	+	0	121	c.121C>T	c.(121-123)Ctc>Ttc	p.L41F		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily A, member 16 (OR4A16), mRNA.	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GGTGGGAAACCTCCTCATTTG	0.428000														85			49		0	0	0.014410	0	0
ATP13A4	84239	broad.mit.edu	37	3	193132518	193132518	+	Missense_Mutation	SNP	G	C	C			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr3:193132518G>C	uc003ftd.3	-	25	2972	c.2864C>G	c.(2863-2865)cCt>cGt	p.P955R	ATP13A4_uc010hzi.3_Non-coding_Transcript	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	Homo sapiens ATPase type 13A4 (ATP13A4), mRNA.	955					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CACCAGCTTAGGGTAGGCACC	0.408000														36			20		0	0	0.010504	0	0
EFNB2	1948	broad.mit.edu	37	13	107148096	107148096	+	Splice_Site	SNP	C	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr13:107148096C>T	uc001vqi.3	-	3	575	c.499_splice	c.e3+1	p.D167_splice		NM_004093	NP_004084	P52799	EFNB2_HUMAN	Homo sapiens ephrin-B2 (EFNB2), mRNA.	167					cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					TGGTCTTTACCTTGTCCAACT	0.512000														452			8		0	0	0.008291	0	0
ANAPC4	29945	broad.mit.edu	37	4	25396298	25396298	+	Missense_Mutation	SNP	A	G	G			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr4:25396298A>G	uc003gro.3	+	12	1076	c.947A>G	c.(946-948)gAa>gGa	p.E316G	ANAPC4_uc003grp.3_Missense_Mutation_p.E201G|ANAPC4_uc010ieu.1_Intron|ANAPC4_uc010iet.1_Missense_Mutation_p.E96G	NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	Homo sapiens anaphase promoting complex subunit 4 (ANAPC4), mRNA.	316					G2/M transition of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	27		Breast(46;0.0503)				TGTAGTGCTGAACTTCAGACT	0.308000														55			40		0	0	0.006230	0	0
KLRG2	346689	broad.mit.edu	37	7	139164445	139164445	+	Silent	SNP	C	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr7:139164445C>T	uc003vvb.3	-	2	1002	c.933G>A	c.(931-933)gcG>gcA	p.A311A	KLRG2_uc010lnc.3_Intron	NM_198508	NP_940910	A4D1S0	KLRG2_HUMAN	Homo sapiens killer cell lectin-like receptor subfamily G, member 2 (KLRG2), mRNA.	311	C-type lectin.					integral to membrane	sugar binding			central_nervous_system(1)|large_intestine(2)|lung(3)	6	Melanoma(164;0.233)					CCCAGGCCTGCGCTTCTGCAG	0.617000														157			4		0	0	0.009096	0	0
MACF1	23499	broad.mit.edu	37	1	39835802	39835802	+	Missense_Mutation	SNP	C	G	G			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr1:39835802C>G	uc021olw.1	+	14	8359	c.8359C>G	c.(8359-8361)Cct>Gct	p.P2787A	MACF1_uc021ols.1_Missense_Mutation_p.P2285A|MACF1_uc001cdc.2_Missense_Mutation_p.P2285A|MACF1_uc021olt.1_Missense_Mutation_p.P2285A|MACF1_uc001cda.1_Missense_Mutation_p.P2193A|MACF1_uc001cdb.1_Missense_Mutation_p.P1372A	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	Homo sapiens microtubule-actin crosslinking factor 1 (MACF1), transcript variant 1, mRNA.	4352					Golgi to plasma membrane protein transport|Wnt receptor signaling pathway|cell cycle arrest|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|wound healing	Golgi apparatus|microtubule|ruffle membrane	ATPase activity|actin filament binding|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAGTATTCCACCTACGGAAAC	0.448000														13			18		0	0	0.004990	0	0
ADCY2	108	broad.mit.edu	37	5	7820695	7820695	+	Missense_Mutation	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr5:7820695G>A	uc003jdz.1	+	23	3083	c.3016G>A	c.(3016-3018)Gtg>Atg	p.V1006M	ADCY2_uc011cmo.1_Missense_Mutation_p.V826M|ADCY2_uc010itm.1_Missense_Mutation_p.V202M	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	Homo sapiens adenylate cyclase 2 (brain) (ADCY2), mRNA.	1006					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						CCATGGACCTGTGATAGCTGG	0.428000														23			27		0	0	0.008361	0	0
KCND2	3751	broad.mit.edu	37	7	119915491	119915491	+	Missense_Mutation	SNP	G	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr7:119915491G>T	uc003vjj.1	+	0	1770	c.805G>T	c.(805-807)Gcc>Tcc	p.A269S		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	Homo sapiens potassium voltage-gated channel, Shal-related subfamily, member 2 (KCND2), mRNA.	269					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					CGACGTGGTGGCCATCCTGCC	0.512000														57			22		1.22574e-08	1.40733e-08	0.014323	1	0
TMEM81	388730	broad.mit.edu	37	1	205052751	205052751	+	Missense_Mutation	SNP	G	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr1:205052751G>T	uc001hbt.3	-	0	838	c.698C>A	c.(697-699)gCc>gAc	p.A233D		NM_203376	NP_976310	Q6P7N7	TMM81_HUMAN	Homo sapiens transmembrane protein 81 (TMEM81), mRNA.	233						integral to membrane		p.A233T(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			CACTCCAATGGCAATTCCTAT	0.512000														65			28		1.30897e-18	1.5913e-18	0.009535	1	0
TRIP4	9325	broad.mit.edu	37	15	64702017	64702017	+	Missense_Mutation	SNP	T	C	C			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr15:64702017T>C	uc002anm.3	+	6	1093	c.1033T>C	c.(1033-1035)Tat>Cat	p.Y345H		NM_016213	NP_057297	Q15650	TRIP4_HUMAN	Homo sapiens thyroid hormone receptor interactor 4 (TRIP4), mRNA.	345					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21						ACTAGCAGAGTATCATAGCAG	0.428000														45			21		0	0	0.014323	0	0
PARM1	25849	broad.mit.edu	37	4	75937687	75937687	+	Silent	SNP	G	C	C			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr4:75937687G>C	uc003hih.2	+	1	349	c.96G>C	c.(94-96)ccG>ccC	p.P32P		NM_015393	NP_056208	Q6UWI2	PARM1_HUMAN	Homo sapiens prostate androgen-regulated mucin-like protein 1 (PARM1), mRNA.	32					positive regulation of telomerase activity	Golgi membrane|early endosome|endosome membrane|integral to membrane|late endosome|plasma membrane				cervix(1)|endometrium(2)|lung(4)|ovary(1)	8						TTTCTCTTCCGACAAACATTG	0.488000														32			30		0	0	0.007291	0	0
SLC6A13	6540	broad.mit.edu	37	12	335609	335609	+	Missense_Mutation	SNP	A	G	G			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr12:335609A>G	uc001qic.2	-	8	1097	c.1007T>C	c.(1006-1008)cTg>cCg	p.L336P	SLC6A13_uc009zdj.2_Missense_Mutation_p.L326P|SLC6A13_uc010sdl.2_Missense_Mutation_p.L244P	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	Homo sapiens solute carrier family 6 (neurotransmitter transporter, GABA), member 13 (SLC6A13), transcript variant 1, mRNA.	336					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CATGAAGCCCAGGATGGAGAA	0.622000														23			36		0	0	0.004878	0	0
FRG1B	284802	broad.mit.edu	37	20	29624093	29624093	+	Splice_Site	SNP	G	T	T	rs75468660		TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr20:29624093G>T	uc010ztl.1	+	1	58	c.26_splice	c.e1+1	p.R9_splice	FRG1B_uc002wvm.1_Intron|FRG1B_uc010ztj.1_Intron|FRG1B_uc010gdr.1_Intron|FRG1B_uc010ztk.1_Intron					Homo sapiens FSHD region gene 1 family, member B (FRG1B), non-coding RNA.									p.?(6)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						CTGATTCCAGGTGAGCTTATG	0.299000														18			3		0.00909568	0.00955817	0.009096	1	0
TAS2R20	259295	broad.mit.edu	37	12	11150353	11150353	+	Missense_Mutation	SNP	A	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr12:11150353A>T	uc001qzm.2	-	0	122	c.122T>A	c.(121-123)aTc>aAc	p.I41N	PRH1_uc001qzb.4_Intron|TAS2R14_uc021qve.1_Intron|PRH1_uc021qvg.1_Intron|PRB4_uc001qzf.1_Intron|TAS2R14_uc001qzj.3_Intron	NM_176889	NP_795370	P59543	T2R20_HUMAN	Homo sapiens taste receptor, type 2, member 20 (TAS2R20), mRNA.	41					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						AGCTGAGGAGATCTTTTGTCT	0.378000														30			56		0	0	0.014410	0	0
NCOA1	8648	broad.mit.edu	37	2	24930397	24930397	+	Silent	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr2:24930397G>A	uc002rfk.3	+	10	2317	c.2058G>A	c.(2056-2058)cgG>cgA	p.R686R	NCOA1_uc010eye.3_Silent_p.R686R|NCOA1_uc002rfi.3_Silent_p.R535R|NCOA1_uc002rfj.3_Silent_p.R686R|NCOA1_uc002rfl.3_Silent_p.R686R	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	Homo sapiens nuclear receptor coactivator 1 (NCOA1), transcript variant 1, mRNA.	686									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACAGAACGGCATAAAATTC	0.483000			T	PAX3	alveolar rhadomyosarcoma									146			4		0	0	0.000602	0	0
PADI3	51702	broad.mit.edu	37	1	17609568	17609568	+	Silent	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr1:17609568G>A	uc001bai.3	+	15	2029	c.1989G>A	c.(1987-1989)gtG>gtA	p.V663V		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	Homo sapiens peptidyl arginine deiminase, type III (PADI3), mRNA.	663					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GGAACATGGTGCCCTGAGACA	0.572000														41			10		0	0	0.010729	0	0
ADCY9	115	broad.mit.edu	37	16	4165346	4165346	+	Missense_Mutation	SNP	T	G	G			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr16:4165346T>G	uc002cvx.3	-	1	637	c.98A>C	c.(97-99)aAc>aCc	p.N33T		NM_001116	NP_001107	O60503	ADCY9_HUMAN	Homo sapiens adenylate cyclase 9 (ADCY9), mRNA.	33					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	ATP binding|adenylate cyclase activity|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CTGCTTGGGGTTGATCTTGAC	0.637000														13			11		0	0	0.010729	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904125	21904125	+	RNA	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr17:21904125G>A	uc002gza.2	+	0		c.64G>A								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		ggagtcgcaaggggccgagca	0.697000														50			4		0	0	0.009096	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr9:20414340G>A	uc003zoe.2	-	4	763	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_uc011lne.1_Silent_p.S136S|MLLT3_uc011lnf.1_Silent_p.S165S|MLLT3_uc003zof.3_5'UTR	NM_004529	NP_004520	P42568	AF9_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), mRNA.	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)|p.S168S(10)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL									37			4		0	0	0.009096	0	0
KIAA1522	57648	broad.mit.edu	37	1	33237745	33237745	+	Missense_Mutation	SNP	C	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr1:33237745C>A	uc001bvu.1	+	5	3009	c.2965C>A	c.(2965-2967)Cct>Act	p.P989T	KIAA1522_uc010ohm.1_Missense_Mutation_p.P941T|KIAA1522_uc001bvv.2_Missense_Mutation_p.P930T|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	Homo sapiens KIAA1522 (KIAA1522), transcript variant 1, mRNA.	930	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GCCCGTGTCCCCTGAGACCCA	0.647000														21			12		0.00136819	0.00148821	0.013537	1	0
SRSF6	6431	broad.mit.edu	37	20	42087023	42087023	+	Missense_Mutation	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr20:42087023G>A	uc010zwg.2	+	1	300	c.130G>A	c.(130-132)Gac>Aac	p.D44N	SRSF6_uc002xki.3_5'UTR	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	Homo sapiens serine/arginine-rich splicing factor 6 (SRSF6), transcript variant 1, mRNA.	44	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	RNA binding|nucleotide binding|protein binding	p.D44N(1)		haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						GGAGTTCGAGGACTCCCGCGA	0.716000														7			8		0	0	0.004482	0	0
TBC1D15	64786	broad.mit.edu	37	12	72288466	72288466	+	Splice_Site	SNP	A	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr12:72288466A>T	uc001swu.3	+	8	784	c.709_splice	c.e8-1	p.K237_splice	TBC1D15_uc009zrv.2_Splice_Site_p.K121_splice|TBC1D15_uc001sww.3_Splice_Site|TBC1D15_uc010stt.2_Splice_Site_p.K228_splice|TBC1D15_uc001swv.3_Splice_Site_p.K220_splice	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	Homo sapiens TBC1 domain family, member 15 (TBC1D15), transcript variant 1, mRNA.	237							Rab GTPase activator activity|protein binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TACTGCATAGAAAATTAAAAA	0.323000														39			45		0	0	0.010771	0	0
WNK3	65267	broad.mit.edu	37	X	54319393	54319393	+	Missense_Mutation	SNP	A	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chrX:54319393A>T	uc004dtc.2	-	9	2404	c.1965T>A	c.(1963-1965)caT>caA	p.H655Q	WNK3_uc004dtd.2_Missense_Mutation_p.H655Q	NM_020922	NP_065973	Q9BYP7	WNK3_HUMAN	Homo sapiens WNK lysine deficient protein kinase 3 (WNK3), transcript variant 1, mRNA.	655					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						GTCCAAGGACATGTACAGGTA	0.418000														5			18		0	0	0.004990	0	0
CR2	1380	broad.mit.edu	37	1	207642031	207642031	+	Missense_Mutation	SNP	A	C	C			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr1:207642031A>C	uc001hfw.3	+	2	724	c.605A>C	c.(604-606)aAa>aCa	p.K202T	CR2_uc001hfv.3_Missense_Mutation_p.K202T|CR2_uc009xch.3_Missense_Mutation_p.K202T|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	Homo sapiens complement component (3d/Epstein Barr virus) receptor 2 (CR2), transcript variant 2, mRNA.	202	Sushi 3.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TCTTCGGGAAAATGGAGTGCT	0.413000														88			71		0	0	0.014410	0	0
ENPEP	2028	broad.mit.edu	37	4	111397845	111397845	+	Missense_Mutation	SNP	G	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr4:111397845G>A	uc003iab.4	+	0	617	c.275G>A	c.(274-276)cGa>cAa	p.R92Q		NM_001977	NP_001968	Q07075	AMPE_HUMAN	Homo sapiens glutamyl aminopeptidase (aminopeptidase A) (ENPEP), mRNA.	92					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AAAAACTTTCGACTGCCGGAC	0.612000														49			32		0	0	0.008361	0	0
ABLIM2	84448	broad.mit.edu	37	4	8021392	8021392	+	Missense_Mutation	SNP	C	T	T			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr4:8021392C>T	uc003gko.3	-	12	1420	c.1277G>A	c.(1276-1278)gGc>gAc	p.G426D	ABLIM2_uc003gkk.3_Missense_Mutation_p.G89D|ABLIM2_uc003gkl.3_Missense_Mutation_p.G153D|ABLIM2_uc003gkm.4_Intron|ABLIM2_uc003gkp.3_Intron|ABLIM2_uc003gkq.3_Missense_Mutation_p.G426D|ABLIM2_uc003gkr.3_Intron|ABLIM2_uc003gkj.4_Missense_Mutation_p.G459D|ABLIM2_uc003gks.3_Intron	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	Homo sapiens actin binding LIM protein family, member 2 (ABLIM2), transcript variant 2, mRNA.	426					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						ATCTTTTACGCCAGTGTCTGG	0.463000														47			3		0	0	0.004672	0	0
SPEG	10290	broad.mit.edu	37	2	220338577	220338577	+	Silent	SNP	C	A	A			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr2:220338577C>A	uc010fwg.3	+	17	4399	c.4399C>A	c.(4399-4401)Cga>Aga	p.R1467R		NM_005876	NP_005867	Q15772	SPEG_HUMAN	Homo sapiens SPEG complex locus (SPEG), transcript variant 1, mRNA.	1467	Ig-like 7.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTGCACCGCCCGAAACCGTCA	0.647000														59			72		7.42073e-21	9.20171e-21	0.014410	1	0
CMBL	134147	broad.mit.edu	37	5	10288604	10288609	+	In_Frame_Del	DEL	AAGGCT	-	-			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr5:10288604_10288609delAAGGCT	uc003jes.3	-	2	699_704	c.248_253delAGCCTT	c.(247-255)gagccttgg>ggg	p.83_85EPW>G		NM_138809	NP_620164	Q96DG6	CMBL_HUMAN	Homo sapiens carboxymethylenebutenolidase homolog (Pseudomonas) (CMBL), mRNA.	83						cytosol	hydrolase activity|protein binding			endometrium(1)|large_intestine(1)|lung(9)|skin(1)|stomach(1)	13						GAGGGGTCCCAAGGCTCTTGCCCTAC	0.456													---	71	---	---	32	---					
CPEB4	80315	broad.mit.edu	37	5	173317605	173317605	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr5:173317605delG	uc003mcs.4	+	0	2275	c.869delG	c.(868-870)agtfs	p.S290fs	CPEB4_uc010jju.2_Frame_Shift_Del_p.S290fs|CPEB4_uc010jjv.3_Frame_Shift_Del_p.S290fs|CPEB4_uc011dfg.2_Frame_Shift_Del_p.S290fs|CPEB4_uc003mcu.4_5'Flank	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	Homo sapiens cytoplasmic polyadenylation element binding protein 4 (CPEB4), mRNA.	290							RNA binding|nucleotide binding	p.Q289H(1)		NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			AGCTACCAGAGTCCGTCACCA	0.572													---	169	---	---	108	---					
STAG3L2	442582	broad.mit.edu	37	7	74300557	74300564	+	Frame_Shift_Del	DEL	AGAGCTCC	-	-			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr7:74300557_74300564delAGAGCTCC	uc022afy.1	-	2	316_323	c.243_250delGGAGCTCT	c.(241-252)ctggagctcttcfs	p.L81fs	STAG3L2_uc011kfj.2_Non-coding_Transcript|STAG3L2_uc022afz.1_Non-coding_Transcript			P0CL84	ST3L2_HUMAN	Homo sapiens stromal antigen 3-like 2 (STAG3L2), non-coding RNA.	81	SCD.					nucleus	binding	p.E82fs*32(4)|p.R80C(1)		breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						CGGCCAGTGAAGAGCTCCAGGCGTGCGG	0.572													---	6	---	---	7	---					
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	-	-	rs11279082		TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr9:100616701_100616706delGCCGCC	uc004axu.3	+	0	1165_1170	c.505_510delGCCGCC	c.(505-510)gccgccdel	p.AA177del		NM_004473	NP_004464	O00358	FOXE1_HUMAN	Homo sapiens forkhead box E1 (thyroid transcription factor 2) (FOXE1), mRNA.	177	Ala-rich.|Poly-Ala.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.767													---	4	---	---	3	---					
C10orf95	79946	broad.mit.edu	37	10	104211148	104211149	+	Frame_Shift_Ins	INS	-	C	C	rs144830667		TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr10:104211148_104211149insC	uc001kvo.1	-	0	152_153	c.77_78insG	c.(76-78)ggafs	p.G26fs	LOC100505761_uc001kvp.2_Intron|LOC100505761_uc001kvq.2_Intron|AX746750_uc001kvr.1_5'Flank	NM_024886	NP_079162	Q9H7T3	CJ095_HUMAN	Homo sapiens chromosome 10 open reading frame 95 (C10orf95), mRNA.	26										liver(1)	1		Colorectal(252;0.207)		Epithelial(162;8.34e-09)|all cancers(201;1.95e-07)|BRCA - Breast invasive adenocarcinoma(275;0.213)		CTCACTTGTCTCCTTCAGCCTT	0.639													---	26	---	---	18	---					
GAPDH	2597	broad.mit.edu	37	12	6646478	6646485	+	Frame_Shift_Del	DEL	TGCCTCCT	-	-			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr12:6646478_6646485delTGCCTCCT	uc001qop.1	+	6	549_556	c.447_454delTGCCTCCT	c.(445-456)aatgcctcctgcfs	p.N149fs		NM_002046	NP_002037	P04406	G3P_HUMAN	Homo sapiens glyceraldehyde-3-phosphate dehydrogenase (GAPDH), mRNA.	149					gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	NAD binding|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|peptidyl-cysteine S-nitrosylase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|lung(4)	7					NADH(DB00157)	TTTGCAGCAATGCCTCCTGCACCACCAA	0.596													---	34	---	---	10	---					
OR4K1	79544	broad.mit.edu	37	14	20404312	20404313	+	Frame_Shift_Del	DEL	AC	-	-			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr14:20404312_20404313delAC	uc001vwj.2	+	0	546_547	c.487_488delAC	c.(487-489)acafs	p.T163fs		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily K, member 1 (OR4K1), mRNA.	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CTTGGCTTTTACAGTGGACCTG	0.465													---	66	---	---	48	---					
MAP3K9	4293	broad.mit.edu	37	14	71275774	71275776	+	In_Frame_Del	DEL	CCT	-	-	rs3832971		TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr14:71275774_71275776delCCT	uc001xmm.3	-	0	113_115	c.113_115delAGG	c.(112-117)gaggcg>gcg	p.E38del	MAP3K9_uc001xml.3_In_Frame_Del_p.E38del	NM_033141	NP_149132	P80192	M3K9_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase 9 (MAP3K9), mRNA.	38	Ala-rich.|Poly-Glu.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity	p.E38delE(2)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GCCGCCGCCGcctcctcctcctc	0.773													---	4	---	---	2	---					
ZNF681	148213	broad.mit.edu	37	19	23927477	23927484	+	Frame_Shift_Del	DEL	TTAAAGGC	-	-			TCGA-DW-5561-01A-01D-1589-08	TCGA-DW-5561-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7722e078-7471-43c1-85f8-2a36938fe489	2c3eb624-d770-4d82-b225-1b58054242b7	g.chr19:23927477_23927484delTTAAAGGC	uc002nrk.4	-	3	1010_1017	c.868_875delGCCTTTAA	c.(868-876)gcctttaatfs	p.A290fs	ZNF681_uc002nrl.4_Frame_Shift_Del_p.A221fs|ZNF681_uc002nrj.4_Frame_Shift_Del_p.A221fs	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	Homo sapiens zinc finger protein 681 (ZNF681), mRNA.	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TAAGGACTGATTAAAGGCTTTGTCACAT	0.375													---	80	---	---	28	---					
