Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SACS	26278	broad.mit.edu	37	13	23909472	23909472	+	Missense_Mutation	SNP	A	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr13:23909472A>T	uc001uon.2	-	9	9132	c.8543T>A	c.(8542-8544)tTc>tAc	p.F2848Y	SACS_uc001uoo.2_Missense_Mutation_p.F2701Y|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	Homo sapiens spastic ataxia of Charlevoix-Saguenay (sacsin) (SACS), mRNA.	2848					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|Hsp70 protein binding|chaperone binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ACCACGTGGGAAAAGAGTAAT	0.408000														81			47		0	0	0.014410	0	0
FBRS	64319	broad.mit.edu	37	16	30676958	30676958	+	Splice_Site	SNP	G	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr16:30676958G>C	uc002dzd.4	+	5	408	c.145_splice	c.e5-1	p.S49_splice	FBRS_uc002dzc.4_Intron	NM_001105079	NP_001098549	Q9HAH7	FBRS_HUMAN	Homo sapiens fibrosin (FBRS), mRNA.	49										ovary(1)	1			Colorectal(24;0.103)			CCCTTTCCCAGAGCACGAACC	0.652000														7			2		0	0	0.004672	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161021130	161021130	+	Missense_Mutation	SNP	C	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr1:161021130C>A	uc001fxl.3	-	9	1740	c.1394G>T	c.(1393-1395)gGc>gTc	p.G465V	ARHGAP30_uc001fxk.3_Missense_Mutation_p.G465V|ARHGAP30_uc001fxm.3_Missense_Mutation_p.G311V|ARHGAP30_uc009wtx.3_Missense_Mutation_p.G138V|ARHGAP30_uc001fxn.1_Missense_Mutation_p.G311V	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Homo sapiens Rho GTPase activating protein 30 (ARHGAP30), transcript variant 1, mRNA.	465					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			aaggccagggccagggccagg	0.612000														30			19		2.35188e-11	2.90527e-11	0.006122	1	0
LPCAT1	79888	broad.mit.edu	37	5	1488543	1488543	+	Silent	SNP	A	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr5:1488543A>T	uc003jcm.3	-	4	747	c.630T>A	c.(628-630)acT>acA	p.T210T		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	Homo sapiens lysophosphatidylcholine acyltransferase 1 (LPCAT1), mRNA.	210					phospholipid biosynthetic process	Golgi membrane|endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TGTTTGTACAAGTTCCTTCTG	0.323000														51			37		0	0	0.008740	0	0
VPS54	51542	broad.mit.edu	37	2	64199372	64199372	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr2:64199372T>A	uc002scq.3	-	3	548	c.385A>T	c.(385-387)Aag>Tag	p.K129*	VPS54_uc002scp.3_Nonsense_Mutation_p.K117*|VPS54_uc010fct.3_Nonsense_Mutation_p.K12*	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	Homo sapiens vacuolar protein sorting 54 homolog (S. cerevisiae) (VPS54), transcript variant 1, mRNA.	129					protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						TCATGAATCTTCTCTCTCTAA	0.303000														36			19		0	0	0.008871	0	0
EPHA6	285220	broad.mit.edu	37	3	97202865	97202865	+	Missense_Mutation	SNP	A	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr3:97202865A>C	uc010how.1	+	9	2205	c.2162A>C	c.(2161-2163)gAt>gCt	p.D721A	EPHA6_uc011bgo.1_Non-coding_Transcript|EPHA6_uc011bgp.1_Missense_Mutation_p.D87A|EPHA6_uc003drs.4_Missense_Mutation_p.D113A|EPHA6_uc003drr.4_Missense_Mutation_p.D113A|EPHA6_uc003drt.3_Missense_Mutation_p.D113A|EPHA6_uc010hox.1_Non-coding_Transcript	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	Homo sapiens EPH receptor A6 (EPHA6), transcript variant 1, mRNA.	626	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AAGGAGATTGATCCCTCAAGA	0.383000														16			25		0	0	0.003330	0	0
TCRBV20S1	0	broad.mit.edu	37	7	142032389	142032389	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr7:142032389G>A	uc011krs.1	+	1	242	c.209G>A	c.(208-210)gGc>gAc	p.G70D	TRBV2_uc011kro.1_Intron|TRBV5-1_uc011krr.1_Intron					Homo sapiens mRNA for T cell receptor V beta6-D-J, partial cds.																		TACTTCCAAGGCAAGGATGCA	0.522000														30			3		0	0	0.004672	0	0
HMOX1	3162	broad.mit.edu	37	22	35779129	35779129	+	Missense_Mutation	SNP	G	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr22:35779129G>T	uc003ant.2	+	1	161	c.54G>T	c.(52-54)aaG>aaT	p.K18N		NM_002133	NP_002124	P09601	HMOX1_HUMAN	Homo sapiens heme oxygenase (decycling) 1 (HMOX1), mRNA.	18					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of chemokine biosynthetic process|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	16					NADH(DB00157)	AGGCCCTGAAGGAGGCCACCA	0.577000														51			25		4.72057e-08	5.71916e-08	0.003954	1	0
PPP1R10	5514	broad.mit.edu	37	6	30577691	30577691	+	Missense_Mutation	SNP	G	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr6:30577691G>T	uc003nqn.1	-	2	583	c.31C>A	c.(31-33)Ctt>Att	p.L11I	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 10 (PPP1R10), mRNA.	11	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|RNA binding|protein phosphatase inhibitor activity|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						CCCTTGAGAAGTTCTTTGGGG	0.468000														52			31		1.55811e-20	2.00328e-20	0.008361	1	0
CSNK2A1	1457	broad.mit.edu	37	20	468205	468205	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr20:468205C>T	uc002wdw.1	-	11	1232	c.839G>A	c.(838-840)cGa>cAa	p.R280Q	CSNK2A1_uc002wdx.1_Missense_Mutation_p.R280Q|CSNK2A1_uc002wdy.1_Missense_Mutation_p.R144Q	NM_177559	NP_808228	P68400	CSK21_HUMAN	Homo sapiens casein kinase 2, alpha 1 polypeptide (CSNK2A1), transcript variant 1, mRNA.	280	Protein kinase.				Wnt receptor signaling pathway|axon guidance	NuRD complex|Sin3 complex|cytosol|plasma membrane	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity	p.R280*(1)		autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			GCGTTCCCATCGCTTTCGAGA	0.502000														39			18		0	0	0.007413	0	0
AXIN1	8312	broad.mit.edu	37	16	354433	354433	+	Silent	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr16:354433G>A	uc002cgp.2	-	4	1514	c.1125C>T	c.(1123-1125)taC>taT	p.Y375Y	LUC7L_uc021szo.1_Intron|AXIN1_uc002cgq.2_Silent_p.Y375Y	NM_003502	NP_003493	O15169	AXIN1_HUMAN	Homo sapiens axin 1 (AXIN1), transcript variant 1, mRNA.	375	Interaction with GSK3B (By similarity).				Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis|activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	GTPase activator activity|I-SMAD binding|armadillo repeat domain binding|beta-catenin binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding	p.?(1)		biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				TCGGCACCCGGTACGTGCGCT	0.617000														35			3		0	0	0.004672	0	0
KIAA1199	57214	broad.mit.edu	37	15	81230320	81230320	+	Splice_Site	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr15:81230320G>A	uc002bfw.1	+	24	3667	c.3407_splice	c.e24+1	p.G1136_splice	KIAA1199_uc010unn.1_Splice_Site_p.G1136_splice	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	Homo sapiens KIAA1199 (KIAA1199), mRNA.	1136										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GAGGACTCAGGGTGAGCAGGC	0.547000														10			9		0	0	0.010729	0	0
URGCP	55665	broad.mit.edu	37	7	43918184	43918184	+	Missense_Mutation	SNP	A	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr7:43918184A>C	uc003tiw.3	-	5	935	c.878T>G	c.(877-879)tTc>tGc	p.F293C	URGCP_uc022acg.1_Intron|URGCP_uc003tiu.3_Missense_Mutation_p.F250C|URGCP_uc003tiv.3_Missense_Mutation_p.F218C|URGCP_uc003tix.3_Missense_Mutation_p.F284C|URGCP_uc003tiy.3_Missense_Mutation_p.F250C|URGCP_uc003tiz.3_Missense_Mutation_p.F250C|URGCP_uc011kbj.2_Missense_Mutation_p.F250C	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	Homo sapiens upregulator of cell proliferation (URGCP), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA.	293					cell cycle	centrosome|nucleus	GTP binding	p.N293Y(1)		breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCGATGCCAGAAGCAGTCCCA	0.602000														47			20		0	0	0.008871	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553676	140553676	+	Silent	SNP	C	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr5:140553676C>T	uc003lit.3	+	0	1434	c.1260C>T	c.(1258-1260)acC>acT	p.T420T		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	Homo sapiens protocadherin beta 7 (PCDHB7), mRNA.	420	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAACATCACCATCACCGTCA	0.512000														71			4		0	0	0.000602	0	0
RPL36A-HNRNPH2	100529097	broad.mit.edu	37	X	100646010	100646010	+	Silent	SNP	C	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chrX:100646010C>T	uc022cag.1	+	0	133	c.87C>T	c.(85-87)cgC>cgT	p.R29R	RPL36A-HNRNPH2_uc022cah.1_Silent_p.R29R|BTK_uc010nno.2_5'Flank|RPL36A-HNRNPH2_uc004ehj.2_Silent_p.R29R|RPL36A-HNRNPH2_uc004ehk.3_5'UTR	NM_001199973	NP_001186902			Homo sapiens RPL36A-HNRNPH2 readthrough (RPL36A-HNRNPH2), transcript variant 1, mRNA.																		TTTCTTTCCGCGCCGATAGCG	0.562000											OREG0019892	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		83			36		0	0	0.006999	0	0
ABCA2	20	broad.mit.edu	37	9	139908396	139908396	+	Silent	SNP	G	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr9:139908396G>C	uc004ckm.1	-	27	4472	c.4422C>G	c.(4420-4422)gtC>gtG	p.V1474V	ABCA2_uc022bpy.1_Silent_p.V1375V|ABCA2_uc022bpz.1_Silent_p.V1445V|ABCA2_uc011mem.1_Silent_p.V1444V|ABCA2_uc004ckl.1_Silent_p.V1375V|ABCA2_uc004ckn.1_Non-coding_Transcript	NM_212533	NP_997698	Q9BZC7	ABCA2_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 2 (ABCA2), transcript variant 2, mRNA.	1444					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGAAGCGTTTGACCAGCAGCC	0.672000														17			10		0	0	0.008291	0	0
PLEC	5339	broad.mit.edu	37	8	144997708	144997708	+	Missense_Mutation	SNP	T	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr8:144997708T>A	uc003zaf.1	-	30	6970	c.6800A>T	c.(6799-6801)cAg>cTg	p.Q2267L	PLEC_uc003zab.1_Missense_Mutation_p.Q2130L|PLEC_uc003zac.1_Missense_Mutation_p.Q2134L|PLEC_uc003zad.2_Missense_Mutation_p.Q2130L|PLEC_uc003zae.1_Missense_Mutation_p.Q2098L|PLEC_uc003zag.1_Missense_Mutation_p.Q2108L|PLEC_uc003zah.2_Missense_Mutation_p.Q2116L|PLEC_uc003zaj.2_Missense_Mutation_p.Q2157L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	Homo sapiens plectin (PLEC), transcript variant 6, mRNA.	2267	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGCCTGTGCCTGAGCCCGGGC	0.741000														14			4		0	0	0.000602	0	0
MALAT1	378938	broad.mit.edu	37	11	65270998	65270998	+	RNA	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr11:65270998G>A	uc010roh.2	+	0		c.5766G>A			AF113016_uc001ody.3_Non-coding_Transcript					Homo sapiens metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) (MALAT1), non-coding RNA.																		ATGATGTGCTGTTAGAATCAG	0.303000														121			9		0	0	0.010729	0	0
DNAJC2	27000	broad.mit.edu	37	7	102963052	102963052	+	Missense_Mutation	SNP	A	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr7:102963052A>T	uc003vbo.3	-	8	1090	c.839T>A	c.(838-840)aTa>aAa	p.I280K	PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.3_5'UTR|DNAJC2_uc010lix.3_Missense_Mutation_p.I280K|DNAJC2_uc003vbp.3_5'UTR	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 2 (DNAJC2), transcript variant 1, mRNA.	280					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	DNA binding|Hsp70 protein binding|chromatin binding|histone binding|ubiquitin binding			endometrium(1)|kidney(9)|large_intestine(6)|lung(4)|ovary(1)	21						GAACTTTTTTATCCTTGGATC	0.333000														23			30		0	0	0.009535	0	0
SLC22A5	6584	broad.mit.edu	37	5	131729504	131729504	+	Splice_Site	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr5:131729504G>A	uc003kwx.4	+	10	1922	c.1658_splice	c.e10+1	p.G553_splice	SLC22A5_uc003kww.4_Splice_Site_p.G529_splice	NM_003060	NP_003051	O76082	S22A5_HUMAN	Homo sapiens solute carrier family 22 (organic cation/carnitine transporter), member 5 (SLC22A5), mRNA.	529					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|PDZ domain binding|carnitine transporter activity|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GAGTCAAAGGGTAAGAAGACC	0.542000														87			57		0	0	0.014410	0	0
DDX3X	1654	broad.mit.edu	37	X	41202004	41202004	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chrX:41202004G>A	uc004dfe.3	+	5	1313	c.458G>A	c.(457-459)gGa>gAa	p.G153E	DDX3X_uc010nhf.1_Missense_Mutation_p.G137E|DDX3X_uc011mks.2_Intron|DDX3X_uc004dff.3_Missense_Mutation_p.G153E|DDX3X_uc011mkq.2_Missense_Mutation_p.G137E|DDX3X_uc011mkr.2_Missense_Mutation_p.G153E|DDX3X_uc004dfg.3_Non-coding_Transcript|DDX3X_uc011mkt.1_Non-coding_Transcript	NM_001356	NP_001347	O00571	DDX3X_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked (DDX3X), transcript variant 1, mRNA.	153					interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|RNA binding|protein binding			NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						CTCTTTTCTGGAGGCAACACT	0.363000										HNSCC(61;0.18)				75			48		0	0	0.014410	0	0
ABCA5	23461	broad.mit.edu	37	17	67283846	67283846	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr17:67283846C>T	uc002jif.2	-	13	3167	c.1949G>A	c.(1948-1950)cGa>cAa	p.R650Q	ABCA5_uc002jic.2_5'Flank|ABCA5_uc002jid.2_5'UTR|ABCA5_uc002jie.2_Non-coding_Transcript|ABCA5_uc002jig.2_Missense_Mutation_p.R650Q|ABCA5_uc002jih.2_Missense_Mutation_p.R650Q|ABCA5_uc010dfe.2_Missense_Mutation_p.R650Q	NM_018672	NP_758424	Q8WWZ7	ABCA5_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 5 (ABCA5), transcript variant 1, mRNA.	650	ABC transporter 1.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					TACAATATGTCGAGAACAGGG	0.408000														78			89		0	0	0.014410	0	0
RNF115	27246	broad.mit.edu	37	1	145688091	145688091	+	Missense_Mutation	SNP	T	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr1:145688091T>A	uc001eoj.3	+	8	990	c.786T>A	c.(784-786)caT>caA	p.H262Q		NM_014455	NP_055270	Q9Y4L5	RN115_HUMAN	Homo sapiens ring finger protein 115 (RNF115), mRNA.	262					protein autoubiquitination	cytosol	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13						TGTTTCAGCATGACACATGTC	0.418000														76			37		0	0	0.010771	0	0
BAZ1B	9031	broad.mit.edu	37	7	72907199	72907199	+	Silent	SNP	T	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr7:72907199T>C	uc003tyc.3	-	4	976	c.624A>G	c.(622-624)ggA>ggG	p.G208G		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	Homo sapiens bromodomain adjacent to zinc finger domain, 1B (BAZ1B), mRNA.	208	Mediates the tyrosine-protein kinase activity.				ATP-dependent chromatin remodeling|DNA replication-dependent nucleosome disassembly|chromatin-mediated maintenance of transcription|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				ATTTCCTTTCTCCTTTTTTTA	0.328000														77			23		0	0	0.002780	0	0
PDGFRA	5156	broad.mit.edu	37	4	55139834	55139834	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr4:55139834G>A	uc003han.4	+	9	1826	c.1495G>A	c.(1495-1497)Gtg>Atg	p.V499M	PDGFRA_uc003haa.3_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.V393M|PDGFRA_uc003ham.2_Non-coding_Transcript	NM_006206	NP_006197	P16234	PGFRA_HUMAN	Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA.	499	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of DNA replication|positive regulation of cell migration|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity	p.V499M(2)		NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GACCATCGCCGTGCGATGCCT	0.557000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)				45			19		0	0	0.010504	0	0
POLRMT	5442	broad.mit.edu	37	19	621842	621842	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr19:621842C>T	uc002lpf.1	-	9	1912	c.1856G>A	c.(1855-1857)gGc>gAc	p.G619D		NM_005035	NP_005026	O00411	RPOM_HUMAN	Homo sapiens polymerase (RNA) mitochondrial (DNA directed) (POLRMT), nuclear gene encoding mitochondrial protein, mRNA.	619					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCAGGATGCCGATCTGGGG	0.687000														23			3		0	0	0.004672	0	0
KRT14	3861	broad.mit.edu	37	17	39742796	39742796	+	Silent	SNP	A	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr17:39742796A>C	uc002hxf.2	-	0	352	c.291T>G	c.(289-291)ggT>ggG	p.G97G	JUP_uc010wfs.2_Intron	NM_000526	NP_000517	P02533	K1C14_HUMAN	Homo sapiens keratin 14 (KRT14), mRNA.	97	Head.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				caaagccaccacccaagccag	0.622000														43			8		0	0	0.007413	0	0
ANK3	288	broad.mit.edu	37	10	61836183	61836183	+	Missense_Mutation	SNP	T	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr10:61836183T>C	uc001jky.3	-	36	4794	c.4456A>G	c.(4456-4458)Aga>Gga	p.R1486G	ANK3_uc001jkw.3_Intron|ANK3_uc009xpa.3_Intron|ANK3_uc001jkx.3_Intron|ANK3_uc010qih.2_Intron|ANK3_uc001jkz.4_Intron|ANK3_uc001jkv.3_Intron|ANK3_uc009xpb.1_Intron|ANK3_uc009xpc.1_Non-coding_Transcript	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	1486					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGGAGGGATCTTGTTGCTCCT	0.418000														23			19		0	0	0.012319	0	0
ANP32E	81611	broad.mit.edu	37	1	150201557	150201557	+	Missense_Mutation	SNP	T	G	G			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr1:150201557T>G	uc001etw.3	-	3	711	c.341A>C	c.(340-342)aAt>aCt	p.N114T	ANP32E_uc010pbt.2_5'Flank|ANP32E_uc010pbu.2_Missense_Mutation_p.N66T|ANP32E_uc010pbv.2_Missense_Mutation_p.N73T|ANP32E_uc001etv.4_Missense_Mutation_p.N114T|ANP32E_uc010pbw.1_Intron	NM_030920	NP_001129951	Q9BTT0	AN32E_HUMAN	Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (ANP32E), transcript variant 1, mRNA.	114						cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity			breast(3)|endometrium(3)|lung(7)|skin(1)|urinary_tract(1)	15	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACTTTTCAAATTTTTAAGATT	0.264000														24			18		0	0	0.008871	0	0
VCAN	1462	broad.mit.edu	37	5	82836813	82836813	+	Missense_Mutation	SNP	A	G	G			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr5:82836813A>G	uc003kii.3	+	7	8347	c.7991A>G	c.(7990-7992)gAt>gGt	p.D2664G	VCAN_uc003kij.3_Missense_Mutation_p.D1677G|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.D1328G	NM_004385	NP_004376	P13611	CSPG2_HUMAN	Homo sapiens versican (VCAN), transcript variant 1, mRNA.	2664	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AGCCAACTAGATCACATGGGC	0.453000														103			38		0	0	0.006999	0	0
ATP6V0B	533	broad.mit.edu	37	1	44442960	44442960	+	Silent	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr1:44442960G>A	uc001clf.3	+	5	1425	c.522G>A	c.(520-522)ctG>ctA	p.L174L	ATP6V0B_uc001cld.3_Intron|ATP6V0B_uc001cle.3_Intron|B4GALT2_uc001clg.3_5'Flank|B4GALT2_uc001clh.3_5'Flank|B4GALT2_uc010okl.2_5'Flank			Q99437	VATO_HUMAN	Homo sapiens ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (ATP6V0B), transcript variant 1, mRNA.	116					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transmembrane transporter activity			breast(2)|kidney(1)|large_intestine(3)|lung(3)	9	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				TGGAGAAGCTGAAGTGCTCTC	0.488000														17			16		0	0	0.003163	0	0
NSUN2	54888	broad.mit.edu	37	5	6620280	6620280	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr5:6620280C>T	uc003jdu.3	-	6	1135	c.754G>A	c.(754-756)Gat>Aat	p.D252N	NSUN2_uc003jdt.3_Missense_Mutation_p.D16N|NSUN2_uc011cmk.2_Missense_Mutation_p.D217N|NSUN2_uc003jdv.3_Missense_Mutation_p.D16N	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	Homo sapiens NOP2/Sun domain family, member 2 (NSUN2), transcript variant 1, mRNA.	252						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						CCGTCCACATCTATCTGGAGC	0.493000														66			33		0	0	0.003271	0	0
NHLH1	4807	broad.mit.edu	37	1	160340735	160340735	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr1:160340735G>A	uc021pbs.1	+	0	214	c.214G>A	c.(214-216)Gcc>Acc	p.A72T	NHLH1_uc001fwa.2_Missense_Mutation_p.A72T	NM_005598	NP_005589	Q02575	HEN1_HUMAN	Homo sapiens nescient helix loop helix 1 (NHLH1), mRNA.	72					cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	7	all_cancers(52;7.11e-19)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ccggcgccgcgccACAGCCAA	0.731000														11			4		0	0	0.009096	0	0
GUCY2C	2984	broad.mit.edu	37	12	14796597	14796597	+	Missense_Mutation	SNP	C	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr12:14796597C>T	uc001rcd.3	-	16	1978	c.1841G>A	c.(1840-1842)cGt>cAt	p.R614H		NM_004963	NP_004954	P25092	GUC2C_HUMAN	Homo sapiens guanylate cyclase 2C (heat stable enterotoxin receptor) (GUCY2C), mRNA.	614	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AGATTTCAGACGACCATGGAC	0.398000														143			45		0	0	0.011902	0	0
PSMD6	9861	broad.mit.edu	37	3	64004274	64004274	+	Splice_Site	SNP	C	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr3:64004274C>A	uc003dmb.1	-	6	1010	c.985_splice	c.e6+1	p.A329_splice	PSMD6_uc003dlz.1_Splice_Site_p.A227_splice|PSMD6_uc003dma.1_Splice_Site_p.A276_splice|PSMD6_uc003dmd.1_Splice_Site_p.A238_splice	NM_014814	NP_055629	Q15008	PSMD6_HUMAN	Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 (PSMD6), mRNA.	276	PCI.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|viral reproduction	proteasome complex	ATPase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(1)	13		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000805)|Kidney(15;0.00188)|KIRC - Kidney renal clear cell carcinoma(15;0.00212)		CCTATCCTTACCTAATGATTG	0.388000														19			10		0.000673444	0.000800509	0.008291	1	0
RAB3A	5864	broad.mit.edu	37	19	18313494	18313494	+	Missense_Mutation	SNP	G	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr19:18313494G>C	uc002nie.2	-	1	226	c.57C>G	c.(55-57)ttC>ttG	p.F19L		NM_002866	NP_002857	P20336	RAB3A_HUMAN	Homo sapiens RAB3A, member RAS oncogene family (RAB3A), mRNA.	19					glutamate secretion|protein transport|small GTPase mediated signal transduction	clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|plasma membrane|synaptic vesicle	GTP binding|GTPase activity			NS(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	8						ACATGTAGTCGAAGTTCTGAT	0.582000											OREG0025360	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		112			44		0	0	0.014410	0	0
MSS51	118490	broad.mit.edu	37	10	75185676	75185676	+	Missense_Mutation	SNP	C	T	T	rs143815503	byFrequency	TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr10:75185676C>T	uc009xrh.3	-	5	1104	c.1031G>A	c.(1030-1032)gGc>gAc	p.G344D	MSS51_uc001juc.3_Missense_Mutation_p.G321D|MSS51_uc001jud.3_Missense_Mutation_p.G321D|MSS51_uc009xrg.3_Missense_Mutation_p.G100D	NM_001024593	NP_001019764	Q4VC12	ZMY17_HUMAN	Homo sapiens zinc finger, MYND-type containing 17 (ZMYND17), mRNA.	321							zinc ion binding										CTGAATTGTGCCAGGTTCCAG	0.547000														51			3		0	0	0.009096	0	0
KDM2B	84678	broad.mit.edu	37	12	121947832	121947832	+	Silent	SNP	C	T	T			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr12:121947832C>T	uc001uat.3	-	10	1289	c.1185G>A	c.(1183-1185)agG>agA	p.R395R	KDM2B_uc001uar.3_5'UTR|KDM2B_uc001uas.3_Silent_p.R364R|KDM2B_uc021rfd.1_Silent_p.R364R|KDM2B_uc001uau.3_Silent_p.R278R|KDM2B_uc021rfe.1_Silent_p.R395R|KDM2B_uc001uav.4_Silent_p.R305R	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	Homo sapiens lysine (K)-specific demethylase 2B (KDM2B), transcript variant 1, mRNA.	395					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						TGCTGGGCTTCCTCGGGGCAT	0.577000														35			19		0	0	0.012319	0	0
PHC3	80012	broad.mit.edu	37	3	169847187	169847187	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr3:169847187G>A	uc003fgl.2	-	7	1107	c.1073C>T	c.(1072-1074)cCa>cTa	p.P358L	PHC3_uc010hws.1_Missense_Mutation_p.P346L|PHC3_uc011bpq.1_Missense_Mutation_p.P305L|PHC3_uc011bpr.1_Missense_Mutation_p.P272L	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	Homo sapiens polyhomeotic homolog 3 (Drosophila) (PHC3), mRNA.	346	Gln-rich.|Pro-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GGATGGGGGTGGGTCTTGAGT	0.488000														91			42		0	0	0.007835	0	0
B3GALTL	145173	broad.mit.edu	37	13	31821210	31821210	+	Silent	SNP	A	G	G			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr13:31821210A>G	uc010aaz.3	+	4	431	c.321A>G	c.(319-321)gcA>gcG	p.A107A		NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	Homo sapiens beta 1,3-galactosyltransferase-like (B3GALTL), mRNA.	107					fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		AAGAAGGTGCATGGACCATAC	0.418000														57			24		0	0	0.003954	0	0
IFIT1B	439996	broad.mit.edu	37	10	91143275	91143275	+	Missense_Mutation	SNP	G	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr10:91143275G>C	uc001kgh.3	+	1	285	c.205G>C	c.(205-207)Gag>Cag	p.E69Q	LIPA_uc001kgb.4_Intron|LIPA_uc001kgc.4_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	Homo sapiens interferon-induced protein with tetratricopeptide repeats 1B (IFIT1B), mRNA.	69							binding			endometrium(2)|large_intestine(3)|lung(8)	13						AGGCCAGAATGAGGAAGCCCT	0.448000														116			3		0	0	0.004672	0	0
DNAJC2	27000	broad.mit.edu	37	7	102963053	102963053	+	Missense_Mutation	SNP	T	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr7:102963053T>A	uc003vbo.3	-	8	1089	c.838A>T	c.(838-840)Ata>Tta	p.I280L	PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.3_5'UTR|DNAJC2_uc010lix.3_Missense_Mutation_p.I280L|DNAJC2_uc003vbp.3_5'UTR	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 2 (DNAJC2), transcript variant 1, mRNA.	280					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	DNA binding|Hsp70 protein binding|chromatin binding|histone binding|ubiquitin binding			endometrium(1)|kidney(9)|large_intestine(6)|lung(4)|ovary(1)	21						AACTTTTTTATCCTTGGATCA	0.338000														23			30		0	0	0.009535	0	0
ZNF155	7711	broad.mit.edu	37	19	44501505	44501505	+	Missense_Mutation	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr19:44501505G>A	uc010xwt.1	+	5	1713	c.1529G>A	c.(1528-1530)cGt>cAt	p.R510H	ZNF155_uc002oxy.1_Missense_Mutation_p.R499H|ZNF155_uc002oxz.1_Missense_Mutation_p.R499H	NM_198089	NP_932355	Q12901	ZN155_HUMAN	Homo sapiens zinc finger protein 155 (ZNF155), transcript variant 2, mRNA.	499						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R499H(1)		endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				AGGACATACCGTAAAGACCAG	0.453000														92			4		0	0	0.009096	0	0
ZFP106	64397	broad.mit.edu	37	15	42717056	42717056	+	Missense_Mutation	SNP	A	C	C			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr15:42717056A>C	uc001zpw.3	-	12	5424	c.5097T>G	c.(5095-5097)caT>caG	p.H1699Q	ZFP106_uc001zpu.3_Missense_Mutation_p.H797Q|ZFP106_uc001zpv.3_Missense_Mutation_p.H884Q|ZFP106_uc001zpx.3_Missense_Mutation_p.H927Q	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	Homo sapiens zinc finger protein 106 homolog (mouse) (ZFP106), mRNA.	1699						nucleolus	zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	61		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		TGGTTTTGCTATGGCCCTCCA	0.522000														14			14		0	0	0.001855	0	0
ARID5A	10865	broad.mit.edu	37	2	97216937	97216937	+	Silent	SNP	G	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr2:97216937G>A	uc002swe.3	+	6	772	c.672G>A	c.(670-672)ggG>ggA	p.G224G	ARID5A_uc010yuq.2_Silent_p.G172G|ARID5A_uc002swf.3_Silent_p.G60G|ARID5A_uc002swg.3_Silent_p.G172G	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	Homo sapiens AT rich interactive domain 5A (MRF1-like) (ARID5A), mRNA.	224					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						TGGCCTCTGGGTCTTCTGTGT	0.602000														66			24		0	0	0.003954	0	0
CNNM4	26504	broad.mit.edu	37	2	97427340	97427340	+	Missense_Mutation	SNP	C	A	A			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr2:97427340C>A	uc002swx.3	+	0	702	c.604C>A	c.(604-606)Ctc>Atc	p.L202I		NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	Homo sapiens cyclin M4 (CNNM4), mRNA.	202	DUF21.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						ATTTTCTGGCCTCAACCTCGG	0.587000														69			39		9.62906e-15	1.21326e-14	0.006230	1	0
SUN2	25777	broad.mit.edu	37	22	39146253	39146253	+	Missense_Mutation	SNP	A	G	G			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr22:39146253A>G	uc011anz.2	-	5	653	c.602T>C	c.(601-603)cTc>cCc	p.L201P	SUN2_uc011aoa.2_Missense_Mutation_p.L155P|SUN2_uc003awh.2_Missense_Mutation_p.L166P|SUN2_uc010gxq.2_Missense_Mutation_p.L187P|SUN2_uc003awi.2_Missense_Mutation_p.L166P|SUN2_uc010gxr.2_Missense_Mutation_p.L166P	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	Homo sapiens Sad1 and UNC84 domain containing 2 (SUN2), transcript variant 2, mRNA.	166					centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	SUN-KASH complex|endosome membrane|integral to membrane|nuclear inner membrane	lamin binding|microtubule binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(2)|stomach(1)	15						CACCATCCAGAGTAAGGAGCC	0.602000														30			20		0	0	0.008871	0	0
CD86	942	broad.mit.edu	37	3	121825262	121825263	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr3:121825262_121825263delAT	uc003eet.3	+	3	746_747	c.618_619delAT	c.(616-621)tcattcfs	p.S206fs	CD86_uc011bjo.2_Frame_Shift_Del_p.S124fs|CD86_uc011bjp.2_Frame_Shift_Del_p.S94fs|CD86_uc003eeu.3_Frame_Shift_Del_p.S200fs|CD86_uc021xcz.1_Frame_Shift_Del_p.S200fs	NM_175862	NP_008820	P42081	CD86_HUMAN	Homo sapiens CD86 molecule (CD86), transcript variant 1, mRNA.	206	Ig-like C2-type.				T cell costimulation|interspecies interaction between organisms|positive regulation of T-helper 2 cell differentiation|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of transcription, DNA-dependent		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	TGTCTGTTTCATTCCCTGATGT	0.391													---	189	---	---	177	---					
CEP63	80254	broad.mit.edu	37	3	134250746	134250746	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr3:134250746delG	uc003eqo.1	+	4	731	c.282delG	c.(280-282)atgfs	p.M94fs	CEP63_uc003eql.1_Frame_Shift_Del_p.M94fs|CEP63_uc003eqm.3_Frame_Shift_Del_p.M94fs|CEP63_uc003eqn.1_Frame_Shift_Del_p.M94fs	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	Homo sapiens centrosomal protein 63kDa (CEP63), transcript variant 1, mRNA.	94					DNA damage checkpoint|G2/M transition of mitotic cell cycle|cell division|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						AGATGACCATGGAATATAAGC	0.353													---	39	---	---	41	---					
HLA-C	3107	broad.mit.edu	37	6	31324737	31324737	+	Frame_Shift_Del	DEL	G	-	-	rs41563916		TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr6:31324737delG	uc021yum.1	-	0	220	c.104delC	c.(103-105)ccafs	p.P35fs	HLA-C_uc003ntf.2_Intron|HLA-C_uc003ntg.1_5'Flank|HLA-C_uc003nth.2_Intron|HLA-C_uc003nti.1_5'Flank|HLA-C_uc010jsn.1_5'Flank|HLA-C_uc010jso.2_5'Flank			Q9TNN7	1C05_HUMAN	SubName: Full=Major histocompatibility complex, class I, B; Flags: Fragment;	0	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	MHC class I protein complex|integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						GTGGGAGCCTGGGGGTGAGGA	0.721													---	8	---	---	4	---					
CCDC129	223075	broad.mit.edu	37	7	31683522	31683527	+	In_Frame_Del	DEL	GACTTT	-	-			TCGA-EV-5901-01A-11D-1589-08	TCGA-EV-5901-10A-01D-1589-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	846543e9-145b-4332-9043-5817b55e2208	8623db0f-675b-4d34-ba2b-5c12aa3e9b7b	g.chr7:31683522_31683527delGACTTT	uc011kae.2	+	10	2628_2633	c.2616_2621delGACTTT	c.(2614-2622)acgactttg>acg	p.TL873del	CCDC129_uc011kad.1_In_Frame_Del_p.TL857del|CCDC129_uc003tcj.1_In_Frame_Del_p.TL847del|CCDC129_uc003tci.1_In_Frame_Del_p.TL698del|CCDC129_uc003tck.1_In_Frame_Del_p.TL755del	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	Homo sapiens coiled-coil domain containing 129 (CCDC129), mRNA.	847										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						AGTTCATGACGACTTTGAAAGCCCTT	0.549													---	98	---	---	26	---					
