Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRHDE	29953	broad.mit.edu	37	12	72680574	72680574	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr12:72680574A>G	uc001sxa.3	+	1	923	c.893A>G	c.(892-894)tAt>tGt	p.Y298C		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	Homo sapiens thyrotropin-releasing hormone degrading enzyme (TRHDE), mRNA.	298					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						CAAGCAACCTATTTATCTTTA	0.408000														136			84		0	0	0.000781405	0	0
BEND4	389206	broad.mit.edu	37	4	42146005	42146005	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr4:42146005C>T	uc003gwn.3	-	2	1074	c.494G>A	c.(493-495)cGa>cAa	p.R165Q	BEND4_uc003gwm.3_Missense_Mutation_p.R165Q|BEND4_uc011byy.1_Missense_Mutation_p.R165Q	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	Homo sapiens BEN domain containing 4 (BEND4), transcript variant 1, mRNA.	165										NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						CAAGATCATTCGACTCTCTGA	0.413000														12			11		0	0	0.00010058	0	0
C11orf70	85016	broad.mit.edu	37	11	101937281	101937281	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr11:101937281C>G	uc001pgp.3	+	3	367	c.334C>G	c.(334-336)Cat>Gat	p.H112D	C11orf70_uc001pgo.3_Intron|C11orf70_uc001pgq.3_Missense_Mutation_p.H74D	NM_032930	NP_116319	Q9BRQ4	CK070_HUMAN	Homo sapiens chromosome 11 open reading frame 70 (C11orf70), transcript variant 1, mRNA.	112										breast(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|skin(2)	12	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		GTCATTTTTTCATCGGTTATA	0.303000														24			34		0	0	0.000409698	0	0
FAR2	55711	broad.mit.edu	37	12	29485566	29485566	+	Silent	SNP	T	C	C			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr12:29485566T>C	uc001rit.3	+	10	1559	c.1291T>C	c.(1291-1293)Ttg>Ctg	p.L431L	FAR2_uc001ris.4_Silent_p.L431L|FAR2_uc009zjm.3_Silent_p.L334L	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	Homo sapiens fatty acyl CoA reductase 2 (FAR2), mRNA.	431					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor			central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						GTTGAACTGGTTGGAATACAT	0.398000														46			40		0	0	0.000319135	0	0
PRRC2B	84726	broad.mit.edu	37	9	134350415	134350415	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr9:134350415G>C	uc004can.4	+	14	2954	c.2899G>C	c.(2899-2901)Ggg>Cgg	p.G967R	PRRC2B_uc010mzj.1_Missense_Mutation_p.G550R|PRRC2B_uc004cao.4_Missense_Mutation_p.G325R	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	Homo sapiens proline-rich coiled-coil 2B (PRRC2B), mRNA.	967							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						GCAGGAGCTAGGGGAGGAGAG	0.582000														5			6		0	0	3.59834e-05	0	0
CCDC142	84865	broad.mit.edu	37	2	74702509	74702509	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr2:74702509C>T	uc002slr.3	-	6	2032	c.1639G>A	c.(1639-1641)Gag>Aag	p.E547K	MRPL53_uc002sln.3_5'Flank|CCDC142_uc002slo.3_Non-coding_Transcript|CCDC142_uc002slq.3_Missense_Mutation_p.E540K|CCDC142_uc002slp.2_Missense_Mutation_p.E547K	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	Homo sapiens coiled-coil domain containing 142 (CCDC142), mRNA.	547										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						CCAGCATACTCACTAGGAGCA	0.532000														46			12		0	0	0.00010058	0	0
SLC26A3	1811	broad.mit.edu	37	7	107415276	107415276	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr7:107415276T>G	uc003ver.2	-	15	1930	c.1719A>C	c.(1717-1719)aaA>aaC	p.K573N	SLC26A3_uc003ves.2_Missense_Mutation_p.K538N	NM_000111	NP_000102	P40879	S26A3_HUMAN	Homo sapiens solute carrier family 26, member 3 (SLC26A3), mRNA.	573	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TCCTCAAAGCTTTGTTGCGCT	0.393000														72			57		0	0	0.000781405	0	0
RPRD1A	55197	broad.mit.edu	37	18	33606995	33606995	+	Silent	SNP	C	T	T			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr18:33606995C>T	uc002kzg.3	-	5	663	c.657G>A	c.(655-657)gcG>gcA	p.A219A	RPRD1A_uc002kze.1_Silent_p.A183A|RPRD1A_uc010dmw.3_Silent_p.A183A|RPRD1A_uc010dmx.3_Silent_p.A219A	NM_018170	NP_060640	Q96P16	RPR1A_HUMAN	Homo sapiens regulation of nuclear pre-mRNA domain containing 1A (RPRD1A), mRNA.	219								p.A219A(2)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(2)	12						GCAACATACACGCATCCTCTA	0.373000														21			38		0	0	0.000228196	0	0
RNF213	57674	broad.mit.edu	37	17	78355391	78355391	+	Silent	SNP	C	G	G			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr17:78355391C>G	uc002jyh.2	+	57	14132	c.13989C>G	c.(13987-13989)ggC>ggG	p.G4663G	RNF213_uc021uen.1_Silent_p.G4614G|LOC100294362_uc002jyi.2_Intron	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	SubName: Full=Uncharacterized protein;	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATCCAAAAGGCTTTCTGCAGC	0.562000														62			78		0	0	0.000781405	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74905226	74905226	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr1:74905226T>G	uc001dge.2	+	21	2301	c.2234T>G	c.(2233-2235)aTc>aGc	p.I745S	FPGT-TNNI3K_uc001dgd.3_Missense_Mutation_p.I745S|FPGT-TNNI3K_uc001dgf.2_Missense_Mutation_p.I644S	NM_001112808	NP_001106279	Q59H18	TNI3K_HUMAN	Homo sapiens FPGT-TNNI3K readthrough (FPGT-TNNI3K), transcript variant 1, mRNA.	644	Poly-Ser.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										CGGTACACCATCAAAGCAGAT	0.478000														34			24		0	0	0.000295444	0	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	G	G	rs60608267	by1000genomes	TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr12:132547093A>G	uc001ujn.3	+	46	8333	c.8181A>G	c.(8179-8181)caA>caG	p.Q2727Q	EP400_uc021rgq.1_Silent_p.Q2726Q|EP400_uc001ujm.3_Silent_p.Q2646Q|EP400_uc001ujp.3_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	Homo sapiens E1A binding protein p400 (EP400), mRNA.	2763	Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(18)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.567000														78			9		0	0	0.000442599	0	0
FCGBP	8857	broad.mit.edu	37	19	40408648	40408648	+	Silent	SNP	G	C	C			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr19:40408648G>C	uc002omp.4	-	7	4199	c.4191C>G	c.(4189-4191)ccC>ccG	p.P1397P		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Homo sapiens Fc fragment of IgG binding protein (FCGBP), mRNA.	1397	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGTCATCCTTGGGGTCGCCGT	0.607000														66			27		0	0	0.000279167	0	0
SLC6A14	11254	broad.mit.edu	37	X	115573956	115573956	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chrX:115573956G>A	uc004eqi.3	+	3	579	c.448G>A	c.(448-450)Gaa>Aaa	p.E150K	SLC6A14_uc011mtm.2_Splice_Site	NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	Homo sapiens solute carrier family 6 (amino acid transporter), member 14 (SLC6A14), mRNA.	150					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	TTTTCAAAGTGAACTACCATG	0.323000														46			67		0	0	0.000781405	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr10:38654432A>G	uc010qex.1	+	4	599	c.524A>G	c.(523-525)aAt>aGt	p.N175S	HSD17B7P2_uc001izq.3_Non-coding_Transcript|HSD17B7P2_uc001izo.1_Non-coding_Transcript|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					Homo sapiens hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2 (HSD17B7P2), non-coding RNA.																		TCATCTCGCAATGCAAGGAAA	0.453000														54			6		0	0	3.59834e-05	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	rs121913388		TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr9:21971120G>A	uc003zpk.3	-	1	544	c.238C>T	c.(238-240)Cga>Tga	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.3_3'UTR|CDKN2A_uc010miu.3_Nonsense_Mutation_p.R80*|CDKN2A_uc003zpl.3_Missense_Mutation_p.P94L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	Homo sapiens cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript variant 1, mRNA.	80			R -> L (in a head and neck tumor).|R -> P (in CMM2; loss of CDK4 binding).		G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|Ras protein signal transduction|cell cycle arrest|cell cycle checkpoint|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|replicative senescence	cytosol|nucleus	NF-kappaB binding|cyclin-dependent protein kinase inhibitor activity|protein binding|protein kinase binding	p.0?(1315)|p.R80*(200)|p.?(44)|p.P135L(7)|p.T79fs*37(2)|p.R80Q(2)|p.T79fs*65(2)|p.E61_L94del(2)|p.R80fs*34(2)|p.R80?(2)|p.T79I(2)|p.L65fs*38(1)|p.0(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*41(1)|p.A68fs*3(1)|p.T79T(1)|p.R80L(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726000	R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)|R80*(MEWO_SKIN)	17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)				4			18		0	0	0.000132079	0	0
OR11G2	390439	broad.mit.edu	37	14	20666485	20666485	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr14:20666485A>G	uc010tlb.2	+	0	991	c.991A>G	c.(991-993)Agg>Ggg	p.R331G		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	Homo sapiens olfactory receptor, family 11, subfamily G, member 2 (OR11G2), mRNA.	331					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		atatagtCTTAGGAACAAAGA	0.373000														135			3		0	0	0.000602214	0	0
DNAH1	25981	broad.mit.edu	37	3	52422876	52422876	+	Silent	SNP	C	T	T			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr3:52422876C>T	uc011bef.2	+	58	9679	c.9418C>T	c.(9418-9420)Ctg>Ttg	p.L3140L	DNAH1_uc003ddv.3_5'UTR	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	Homo sapiens dynein, axonemal, heavy chain 1 (DNAH1), mRNA.	3205					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGTGGAGAACCTGCAGTACAT	0.637000														16			33		0	0	0.00058488	0	0
TMEM161B	153396	broad.mit.edu	37	5	87498782	87498782	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr5:87498782G>C	uc003kjc.3	-	8	1036	c.911C>G	c.(910-912)cCt>cGt	p.P304R	TMEM161B_uc011cty.2_Missense_Mutation_p.P293R|TMEM161B_uc010jax.3_Non-coding_Transcript|TMEM161B_uc011ctz.1_Missense_Mutation_p.P171R|TMEM161B_uc011ctx.2_Missense_Mutation_p.P122R	NM_153354	NP_699185	Q8NDZ6	T161B_HUMAN	Homo sapiens transmembrane protein 161B (TMEM161B), mRNA.	304						integral to membrane				endometrium(4)|large_intestine(3)|lung(9)|skin(3)|upper_aerodigestive_tract(1)	20		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		TACTTACAAAGGGATACTTTC	0.368000														138			3		0	0	6.4e-05	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	A	A	rs12366766		TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr12:132547087G>A	uc001ujn.3	+	46	8327	c.8175G>A	c.(8173-8175)caG>caA	p.Q2725Q	EP400_uc021rgq.1_Silent_p.Q2724Q|EP400_uc001ujm.3_Silent_p.Q2644Q|EP400_uc001ujp.3_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	Homo sapiens E1A binding protein p400 (EP400), mRNA.	2761	Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(32)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000														78			14		0	0	0.000308642	0	0
GSTK1	373156	broad.mit.edu	37	7	142965268	142965268	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr7:142965268C>T	uc003wci.3	+	6	707	c.622C>T	c.(622-624)Cac>Tac	p.H208Y	GSTK1_uc011ksy.2_Missense_Mutation_p.H165Y|GSTK1_uc003wcj.3_Missense_Mutation_p.H264Y|GSTK1_uc011ksz.2_Missense_Mutation_p.H196Y	NM_015917	NP_057001	Q9Y2Q3	GSTK1_HUMAN	Homo sapiens glutathione S-transferase kappa 1 (GSTK1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	208						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity			lung(4)	4	Melanoma(164;0.059)				Glutathione(DB00143)	GCTGCTGGCGCACCTGCTGGG	0.567000														345			86		0	0	0.000781405	0	0
AMPD1	270	broad.mit.edu	37	1	115218255	115218255	+	Silent	SNP	G	C	C			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr1:115218255G>C	uc001efe.2	-	11	1722	c.1674C>G	c.(1672-1674)tcC>tcG	p.S558S	AMPD1_uc001eff.2_Silent_p.S554S	NM_000036	NP_000027	P23109	AMPD1_HUMAN	Homo sapiens adenosine monophosphate deaminase 1 (AMPD1), transcript variant 1, mRNA.	525					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TGGGACTCTTGGAGGAGAACA	0.468000														93			39		0	0	0.000319135	0	0
FZD1	8321	broad.mit.edu	37	7	90894984	90894984	+	Silent	SNP	G	T	T			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr7:90894984G>T	uc003ula.3	+	0	1202	c.789G>T	c.(787-789)ccG>ccT	p.P263P		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	Homo sapiens frizzled family receptor 1 (FZD1), mRNA.	263					G-protein signaling, coupled to cGMP nucleotide second messenger|Wnt receptor signaling pathway, calcium modulating pathway|autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding|receptor binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			GCGGCTTCCCGGGGGGCGCCG	0.697000														10			10		1.58986e-06	2.59535e-05	0.000673444	1	0
ZNF684	127396	broad.mit.edu	37	1	41012446	41012446	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr1:41012446A>G	uc001cft.2	+	4	702	c.451A>G	c.(451-453)Aga>Gga	p.R151G		NM_152373	NP_689586	Q5T5D7	ZN684_HUMAN	Homo sapiens zinc finger protein 684 (ZNF684), mRNA.	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|lung(3)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			TAAATATAATAGAAGTTATAC	0.299000														12			26		0	0	0.00047179	0	0
ANKS1A	23294	broad.mit.edu	37	6	35051232	35051232	+	Silent	SNP	C	A	A			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr6:35051232C>A	uc003ojx.4	+	19	3088	c.2946C>A	c.(2944-2946)atC>atA	p.I982I	ANKS1A_uc011dst.2_Silent_p.I522I|ANKS1A_uc010jvp.2_Silent_p.I356I	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	Homo sapiens ankyrin repeat and sterile alpha motif domain containing 1A (ANKS1A), mRNA.	982	PID.					cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CCACCATCATCCTGTCCATCA	0.547000														30			54		2.50483e-33	4.32261e-32	0.000781405	1	0
TDRD5	163589	broad.mit.edu	37	1	179609042	179609042	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr1:179609042A>C	uc010pnp.2	+	9	2107	c.1589A>C	c.(1588-1590)cAt>cCt	p.H530P	TDRD5_uc021pfm.1_Missense_Mutation_p.H530P|TDRD5_uc001gnf.2_Missense_Mutation_p.H530P|TDRD5_uc021pfn.1_Missense_Mutation_p.H530P|TDRD5_uc001gnh.2_Missense_Mutation_p.H85P	NM_001199085	NP_001186014	Q8NAT2	TDRD5_HUMAN	Homo sapiens tudor domain containing 5 (TDRD5), transcript variant 1, mRNA.	530	Tudor.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CAGCCGGGACATCTCTGTTGT	0.418000														216			44		0	0	0.000680045	0	0
ALPPL2	251	broad.mit.edu	37	2	233272617	233272617	+	Missense_Mutation	SNP	G	A	A	rs145892470		TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr2:233272617G>A	uc002vss.4	+	4	591	c.538G>A	c.(538-540)Gcc>Acc	p.A180T		NM_031313	NP_112603	P10696	PPBN_HUMAN	Homo sapiens alkaline phosphatase, placental-like 2 (ALPPL2), mRNA.	180					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CGGCGCCTACGCCCACACGGT	0.627000														118			24		0	0	0.000375601	0	0
ANKRD20A9P	284232	broad.mit.edu	37	13	19409659	19409659	+	RNA	SNP	C	G	G			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr13:19409659C>G	uc010tcj.1	-	0		c.36451G>C								Homo sapiens ankyrin repeat domain 20 family, member A9, pseudogene (ANKRD20A9P), non-coding RNA.																		TAATTACTATCTCTTTATGAT	0.343000														55			23		0	0	0.000295444	0	0
GYS2	2998	broad.mit.edu	37	12	21728873	21728873	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr12:21728873C>T	uc001rfb.3	-	2	677	c.422G>A	c.(421-423)gGc>gAc	p.G141D		NM_021957	NP_068776	P54840	GYS2_HUMAN	Homo sapiens glycogen synthase 2 (liver) (GYS2), mRNA.	141					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						ATAAGGAATGCCGACACTGCA	0.418000														132			5		0	0	0.000602214	0	0
CROCC	9696	broad.mit.edu	37	1	17294710	17294710	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr1:17294710delA	uc001azt.2	+	30	4942	c.4873delA	c.(4873-4875)aagfs	p.K1625fs	CROCC_uc001azu.2_Frame_Shift_Del_p.K928fs|CROCC_uc001azv.2_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	Homo sapiens ciliary rootlet coiled-coil, rootletin (CROCC), mRNA.	1625					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GAAGATCAGCAAGATGAAGGC	0.652													---	4	---	---	2	---					
UBXN11	91544	broad.mit.edu	37	1	26608820	26608843	+	In_Frame_Del	DEL	GGGACTGGGGCCGGGACCGGGACC	-	-	rs66614970	by1000genomes	TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr1:26608820_26608843delGGGACTGGGGCCGGGACCGGGACC	uc001blw.3	-	15	1783_1806	c.1510_1533delGGTCCCGGTCCCGGCCCCAGTCCC	c.(1510-1533)ggtcccggtcccggccccagtcccdel	p.GPGPGPSP504del	UBXN11_uc001bly.3_In_Frame_Del_p.GPGPGPSP384del|UBXN11_uc001blz.1_Splice_Site_p.I469_splice|UBXN11_uc001blx.3_In_Frame_Del_p.GPGPGPSP262del|UBXN11_uc001bma.3_In_Frame_Del_p.GPGPGPSP471del	NM_183008	NP_892120	Q5T124	UBX11_HUMAN	Homo sapiens UBX domain protein 11 (UBXN11), transcript variant 2, mRNA.	504	3 X 8 AA tandem repeats of P-G-P-G-P-G-P- S.|Pro-rich.					cytoplasm|cytoskeleton		p.P503_G504insCP(2)|p.G490_P515delGPGPSPGPGPGPSPGPGPGPSPCPGP(2)		endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(3)	23						gtccaggacagggactggggccgggaccgggaccgggactgggg	0.714													---	22	---	---	9	---					
PTPRC	5788	broad.mit.edu	37	1	198678927	198678927	+	Frame_Shift_Del	DEL	G	-	-			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr1:198678927delG	uc001gur.1	+	10	1319	c.1139delG	c.(1138-1140)agtfs	p.S380fs	PTPRC_uc001gut.1_Frame_Shift_Del_p.S219fs|PTPRC_uc009wzf.1_Frame_Shift_Del_p.S268fs|PTPRC_uc021pgy.1_Frame_Shift_Del_p.S334fs|PTPRC_uc010ppg.1_Frame_Shift_Del_p.S316fs	NM_002838	NP_002829	P08575	PTPRC_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1, mRNA.	380					B cell proliferation|B cell receptor signaling pathway|T cell differentiation|T cell receptor signaling pathway|axon guidance|defense response to virus|immunoglobulin biosynthetic process|negative regulation of T cell mediated cytotoxicity|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|positive regulation of B cell proliferation|positive regulation of T cell proliferation|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of protein kinase activity|regulation of S phase|release of sequestered calcium ion into cytosol	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						ACTAACGCAAGTAAAATTATT	0.274													---	205	---	---	24	---					
POLR1B	84172	broad.mit.edu	37	2	113308552	113308559	+	Frame_Shift_Del	DEL	CTTTCTTC	-	-			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr2:113308552_113308559delCTTTCTTC	uc002thw.2	+	4	1315_1322	c.735_742delCTTTCTTC	c.(733-744)ttctttcttcctfs	p.F245fs	POLR1B_uc010fkn.2_Frame_Shift_Del_p.F189fs|POLR1B_uc002thx.2_Frame_Shift_Del_p.F106fs|POLR1B_uc010fko.2_Frame_Shift_Del_p.F245fs|POLR1B_uc010fkp.2_Intron|POLR1B_uc002thy.2_Frame_Shift_Del_p.F106fs|POLR1B_uc010yxo.1_Frame_Shift_Del_p.F22fs	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	Homo sapiens polymerase (RNA) I polypeptide B, 128kDa (POLR1B), transcript variant 1, mRNA.	245					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						AAGAACTGTTCTTTCTTCCTTTGGGATT	0.394													---	148	---	---	25	---					
OSTalpha	200931	broad.mit.edu	37	3	195955100	195955102	+	In_Frame_Del	DEL	CTG	-	-			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr3:195955100_195955102delCTG	uc003fwd.3	+	4	678_680	c.477_479delCTG	c.(475-480)ccctgc>ccc	p.C164del	OSTalpha_uc010iac.1_In_Frame_Del_p.C48del|OSTalpha_uc003fwe.3_In_Frame_Del_p.C31del	NM_152672	NP_689885	Q86UW1	OSTA_HUMAN	Homo sapiens organic solute transporter alpha (OSTalpha), mRNA.	164	Poly-Cys.					integral to membrane|plasma membrane	transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;8.83e-25)|all cancers(36;8.38e-23)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;7.51e-07)|Lung(62;1.06e-06)	GBM - Glioblastoma multiforme(46;0.00202)		ACACAGGCCCctgctgctgctgc	0.665													---	113	---	---	7	---					
SAV1	60485	broad.mit.edu	37	14	51132011	51132012	+	Frame_Shift_Ins	INS	-	A	A			TCGA-G7-6789-01A-11D-1961-08	TCGA-G7-6789-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73b0f7f3-54f1-4030-b2a9-89bb6b4e6d3e	e2d58fed-dc32-460b-aae1-c39d371dfca5	g.chr14:51132011_51132012insA	uc001wyh.1	-	1	758_759	c.420_421insT	c.(418-423)tttgatfs	p.F140fs	SAV1_uc021rsy.1_Non-coding_Transcript	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	Homo sapiens salvador homolog 1 (Drosophila) (SAV1), mRNA.	140					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)|kidney(2)|lung(2)|prostate(1)	6	all_epithelial(31;0.000611)|Breast(41;0.0333)					CTCTGACCATCAAAAAAATTGT	0.396													---	26	---	---	35	---					
