Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZFHX3	463	broad.mit.edu	37	16	72830449	72830449	+	Silent	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr16:72830449A>G	uc002fck.3	-	8	6805	c.6132T>C	c.(6130-6132)ccT>ccC	p.P2044P	ZFHX3_uc002fcl.3_Silent_p.P1130P	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	2044	Poly-Pro.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.P2044P(2)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GAGGGGGTGGAGGGGGAGGTG	0.622000														116			5		0	0	0.00185496	0	0
PDXDC1	23042	broad.mit.edu	37	16	15130101	15130101	+	Nonsense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr16:15130101C>A	uc002dda.4	+	22	2560	c.2336C>A	c.(2335-2337)tCa>tAa	p.S779*	PDXDC1_uc010uzl.2_Nonsense_Mutation_p.S764*|PDXDC1_uc010uzm.2_Nonsense_Mutation_p.S688*|PDXDC1_uc002ddb.4_Nonsense_Mutation_p.S752*|PDXDC1_uc010uzn.2_Nonsense_Mutation_p.S751*|PDXDC1_uc002ddc.3_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	Homo sapiens pyridoxal-dependent decarboxylase domain containing 1 (PDXDC1), mRNA.	779					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(10)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	GATGACCACTCACAGGTAGAA	0.537000														100			43		1.00953e-15	8.70439e-15	0.000680045	1	0
STARD3	10948	broad.mit.edu	37	17	37817259	37817259	+	Nonsense_Mutation	SNP	G	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr17:37817259G>T	uc002hsd.3	+	12	1263	c.1060G>T	c.(1060-1062)Gag>Tag	p.E354*	STARD3_uc010wei.2_Nonsense_Mutation_p.E354*|STARD3_uc002hse.3_Nonsense_Mutation_p.E336*|STARD3_uc010weh.2_Non-coding_Transcript|STARD3_uc002hsf.3_Nonsense_Mutation_p.E220*	NM_006804	NP_006795	Q14849	STAR3_HUMAN	Homo sapiens StAR-related lipid transfer (START) domain containing 3 (STARD3), transcript variant 1, mRNA.	354	START.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|prostate(2)|stomach(1)	14	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCGGCGCATTGAGCGGCGCAG	0.602000														46			35		1.60099e-16	1.41178e-15	0.000953801	1	0
STK38L	23012	broad.mit.edu	37	12	27468238	27468238	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:27468238C>A	uc001rhr.3	+	8	991	c.792C>A	c.(790-792)aaC>aaA	p.N264K	STK38L_uc010sjm.2_Missense_Mutation_p.N171K|STK38L_uc010sjn.2_Missense_Mutation_p.N2K|STK38L_uc010sjo.2_5'Flank	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	Homo sapiens serine/threonine kinase 38 like (STK38L), mRNA.	264	Protein kinase.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	ATP binding|actin binding|magnesium ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12	Colorectal(261;0.0847)					AGAACATGAACTCAAAGAGGA	0.348000														66			22		1.85244e-09	1.46683e-08	0.00047179	1	0
PFKL	5211	broad.mit.edu	37	21	45741733	45741733	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr21:45741733G>A	uc002zek.3	+	15	1855	c.1454G>A	c.(1453-1455)gGc>gAc	p.G485D	PFKL_uc002zel.3_Missense_Mutation_p.G438D|PFKL_uc002zem.3_Missense_Mutation_p.G25D|PFKL_uc002zen.3_Missense_Mutation_p.G25D			P17858	K6PL_HUMAN	Homo sapiens phosphofructokinase, liver (PFKL), transcript variant 1, non-coding RNA.	438					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		GTGCACGATGGCTTCGAAGGC	0.642000														130			5		0	0	0.00116845	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7669667	7669667	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr11:7669667T>C	uc001mfj.4	+	17	2084	c.1696T>C	c.(1696-1698)Tgg>Cgg	p.W566R	PPFIBP2_uc010rbb.1_Missense_Mutation_p.W489R|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.2_Missense_Mutation_p.W500R|PPFIBP2_uc010rbe.2_Missense_Mutation_p.W454R|PPFIBP2_uc001mfl.4_Missense_Mutation_p.W423R|PPFIBP2_uc009yfj.1_Missense_Mutation_p.W210R	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	Homo sapiens PTPRF interacting protein, binding protein 2 (liprin beta 2) (PPFIBP2), mRNA.	566	SAM 1.				DNA integration|cell communication	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TGTGTGTGCATGGCTGGAGGA	0.547000														61			38		0	0	0.00111076	0	0
KRR1	11103	broad.mit.edu	37	12	75895546	75895546	+	Silent	SNP	T	C	C			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:75895546T>C	uc001sxt.3	-	8	1001	c.960A>G	c.(958-960)gcA>gcG	p.A320A	GLIPR1_uc001sxs.3_3'UTR|KRR1_uc009zsc.3_Silent_p.A263A	NM_007043	NP_008974	Q13601	KRR1_HUMAN	Homo sapiens KRR1, small subunit (SSU) processome component, homolog (yeast) (KRR1), mRNA.	320	Lys-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(1)	11						GTGGAATAAATGCTTTGTTTC	0.279000														41			16		0	0	0.00121646	0	0
C1orf187	374946	broad.mit.edu	37	1	11771907	11771907	+	Splice_Site	SNP	G	A	A	rs147444302		TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:11771907G>A	uc001asr.1	+	4	783	c.643_splice	c.e4-1	p.Q215_splice		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	Homo sapiens chromosome 1 open reading frame 187 (C1orf187), mRNA.	215					Wnt receptor signaling pathway|axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway	extracellular region				breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(2)	15	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		ACGGTCTCCAGCAGGCACAGC	0.552000														20			6		0	0	0.00116845	0	0
AGT	183	broad.mit.edu	37	1	230841791	230841791	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:230841791C>T	uc001hty.4	-	2	1520	c.1012G>A	c.(1012-1014)Gag>Aag	p.E338K	AGT_uc009xff.3_Missense_Mutation_p.E310K	NM_000029	NP_000020	P01019	ANGT_HUMAN	Homo sapiens angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (AGT), mRNA.	338					G-protein signaling, coupled to cGMP nucleotide second messenger|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	CAGGCGCTCTCAGTGAAGGGC	0.557000														86			51		0	0	0.000781405	0	0
FYCO1	79443	broad.mit.edu	37	3	46008824	46008824	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr3:46008824C>T	uc011bal.1	-	6	2114	c.2002G>A	c.(2002-2004)Gcc>Acc	p.A668T	FYCO1_uc003cpb.4_Missense_Mutation_p.A668T	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	Homo sapiens FYVE and coiled-coil domain containing 1 (FYCO1), mRNA.	668					transport	integral to membrane	metal ion binding|protein binding			NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CGGATGCTGGCCTGCTCGGCC	0.632000														70			52		0	0	0.000781405	0	0
ARSI	340075	broad.mit.edu	37	5	149677576	149677576	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr5:149677576G>A	uc003lrv.2	-	1	1500	c.911C>T	c.(910-912)tCg>tTg	p.S304L		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	Homo sapiens arylsulfatase family, member I (ARSI), mRNA.	304						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTGCCCCCCGAGAAAGTCTG	0.587000														37			26		0	0	0.000720815	0	0
ERLIN1	10613	broad.mit.edu	37	10	101911987	101911987	+	Silent	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr10:101911987A>G	uc001kqn.4	-	10	1299	c.948T>C	c.(946-948)taT>taC	p.Y316Y	ERLIN1_uc001kqo.4_Silent_p.Y316Y|ERLIN1_uc010qpm.2_Silent_p.Y232Y	NM_006459	NP_006450	O75477	ERLN1_HUMAN	Homo sapiens ER lipid raft associated 1 (ERLIN1), mRNA.	314					ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding						Colorectal(252;0.234)		Epithelial(162;3.85e-10)|all cancers(201;3.25e-08)		TAATATCTGAATATTTCAAAG	0.443000														71			49		0	0	0.000680045	0	0
CST9L	128821	broad.mit.edu	37	20	23548869	23548869	+	Silent	SNP	G	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr20:23548869G>T	uc002wtk.4	-	0	518	c.219C>A	c.(217-219)atC>atA	p.I73I		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	Homo sapiens cystatin 9-like (CST9L), mRNA.	73						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8	Colorectal(13;0.0431)|Lung NSC(19;0.235)					AGGAATTCAAGATGTGCCCCA	0.547000														41			17		3.41278e-10	2.75867e-09	0.000566183	1	0
CALU	813	broad.mit.edu	37	7	128407599	128407599	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr7:128407599C>A	uc022ald.1	+	6	1700	c.757C>A	c.(757-759)Cgt>Agt	p.R253S	CALU_uc022alg.1_Missense_Mutation_p.R171S|CALU_uc022alh.1_Missense_Mutation_p.R171S|CALU_uc022ali.1_Missense_Mutation_p.R93S|CALU_uc003vns.3_Missense_Mutation_p.R245S|CALU_uc003vnr.3_Missense_Mutation_p.R253S|CALU_uc003vnq.3_Missense_Mutation_p.R245S|CALU_uc022ale.1_Intron|CALU_uc022alf.1_Missense_Mutation_p.R94S	NM_001199672	NP_001186601	O43852	CALU_HUMAN	Homo sapiens calumenin (CALU), transcript variant 4, mRNA.	245	EF-hand 5.				platelet activation|platelet degranulation	Golgi apparatus|extracellular region|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding			kidney(2)|large_intestine(3)|lung(5)	10						GGATAAGAACCGTGATGGGAA	0.488000														117			4		0.000602214	0.00458155	0.000602214	1	0
NDUFAF4	29078	broad.mit.edu	37	6	97344647	97344647	+	Silent	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr6:97344647A>G	uc003pow.3	-	1	303	c.213T>C	c.(211-213)gaT>gaC	p.D71D	NDUFAF4_uc003pov.3_Non-coding_Transcript	NM_014165	NP_054884	Q9P032	NDUF4_HUMAN	Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 (NDUFAF4), nuclear gene encoding mitochondrial protein, mRNA.	71					mitochondrial respiratory chain complex I assembly	mitochondrial membrane	calmodulin binding			large_intestine(5)|lung(3)|ovary(1)|skin(1)	10						GATCTTTGGAATCAACATACA	0.358000														69			27		0	0	0.001512	0	0
CTDSPL	10217	broad.mit.edu	37	3	38009318	38009318	+	Splice_Site	SNP	C	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr3:38009318C>G	uc003chg.3	+	5	392	c.370_splice	c.e5-1	p.P124_splice	CTDSPL_uc003chh.3_Splice_Site_p.P113_splice	NM_001008392	NP_001008393	O15194	CTDSL_HUMAN	Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (CTDSPL), transcript variant 1, mRNA.	124	FCP1 homology.					nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|large_intestine(4)|skin(1)	8		Melanoma(1037;0.0122)		KIRC - Kidney renal clear cell carcinoma(284;0.0729)|Kidney(284;0.0902)		TTTCTCTAGCCTATTAGTAAT	0.308000											OREG0015472	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		30			12		0	0	0.000978159	0	0
CXCR1	3577	broad.mit.edu	37	2	219029397	219029397	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr2:219029397G>C	uc021vwq.1	-	0	538	c.538C>G	c.(538-540)Cca>Gca	p.P180A	CXCR1_uc002vhc.3_Missense_Mutation_p.P180A|HV303425_uc021vwr.1_Non-coding_Transcript	NM_000634	NP_000625	P25024	CXCR1_HUMAN	Homo sapiens chemokine (C-X-C motif) receptor 1 (CXCR1), mRNA.	180					dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(3)	13						GAATTGTTTGGATGGTAAGCC	0.512000														20			12		0	0	0.00136819	0	0
CHCHD3	54927	broad.mit.edu	37	7	132709362	132709362	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr7:132709362T>A	uc022alw.1	-	2	326	c.195A>T	c.(193-195)agA>agT	p.R65S	CHCHD3_uc003vre.3_Missense_Mutation_p.R65S|CHCHD3_uc010lmi.3_Non-coding_Transcript|CHCHD3_uc011kpn.1_Missense_Mutation_p.R65S	NM_017812	NP_060282	Q9NX63	CHCH3_HUMAN	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 3 (CHCHD3), mRNA.	65					inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	7						CCTCAGCTACTCTTCTTTTCA	0.383000														149			18		0	0	0.00074312	0	0
TSC2	7249	broad.mit.edu	37	16	2138135	2138135	+	Missense_Mutation	SNP	G	A	A	rs137854164		TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr16:2138135G>A	uc002con.3	+	39	5261	c.5155G>A	c.(5155-5157)Gca>Aca	p.A1719T	TCRBV20S1_uc021tak.1_Intron|TSC2_uc010bsd.3_Missense_Mutation_p.A1696T|TSC2_uc002coo.3_Missense_Mutation_p.A1652T|TSC2_uc010uvv.2_Missense_Mutation_p.A1616T|TSC2_uc010uvw.2_Missense_Mutation_p.A1604T|TSC2_uc002cop.3_Missense_Mutation_p.A1475T|TSC2_uc002coq.3_Missense_Mutation_p.A494T	NM_000548	NP_000539	P49815	TSC2_HUMAN	Homo sapiens tuberous sclerosis 2 (TSC2), transcript variant 1, mRNA.	1719	Rap-GAP.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|TSC1-TSC2 complex|nucleus|perinuclear region of cytoplasm	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				GGCCCTGCACGCAAATGTGAG	0.652000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis					64			36		0	0	0.000814825	0	0
KRT18	3875	broad.mit.edu	37	12	53344644	53344644	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:53344644A>G	uc001sbe.3	+	3	680	c.611A>G	c.(610-612)gAg>gGg	p.E204G	KRT18_uc009zmn.2_Missense_Mutation_p.E204G|KRT18_uc001sbg.3_Missense_Mutation_p.E204G|KRT8_uc009zml.1_5'Flank|KRT8_uc009zmm.1_5'Flank	NM_199187	NP_954657	P05783	K1C18_HUMAN	Homo sapiens keratin 18 (KRT18), transcript variant 2, mRNA.	204	Coil 1B.|Necessary for interaction with PNN.|Rod.				Golgi to plasma membrane CFTR protein transport|anatomical structure morphogenesis|cell cycle|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	11						ACAGAGATCGAGGCTCTCAAG	0.577000														13			4		0	0	0.00024832	0	0
RAB3D	9545	broad.mit.edu	37	19	11447891	11447891	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr19:11447891T>A	uc002mqx.3	-	1	446	c.185A>T	c.(184-186)aAg>aTg	p.K62M		NM_004283	NP_004274	O95716	RAB3D_HUMAN	Homo sapiens RAB3D, member RAS oncogene family (RAB3D), mRNA.	62					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|ovary(2)	14						GTAGACGGTCTTGACCTTGAA	0.577000														223			106		0	0	0.000781405	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946396	16946396	+	RNA	SNP	C	T	T	rs367013	byFrequency	TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:16946396C>T	uc010ocf.2	-	2		c.502G>A			CROCCP2_uc009vov.2_Non-coding_Transcript|CROCCP2_uc001aze.3_Non-coding_Transcript|CROCCP2_uc001azf.3_Non-coding_Transcript					Homo sapiens ciliary rootlet coiled-coil, rootletin pseudogene 2 (CROCCP2), non-coding RNA.																		TGCTGCAGGGCAGCAATCTCC	0.667000														30			4		0	0	0.000602214	0	0
KLRK1	22914	broad.mit.edu	37	12	10539567	10539567	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:10539567C>T	uc009zhj.3	-	2	260	c.83G>A	c.(82-84)aGt>aAt	p.S28N	AK096314_uc001qya.1_Intron|KLRK1_uc001qyb.3_Non-coding_Transcript|KLRK1_uc001qyc.3_Missense_Mutation_p.S28N|KLRK1_uc009zhk.3_Missense_Mutation_p.S28N|KLRK1_uc001qyd.3_Missense_Mutation_p.S28N	NM_007360	NP_001186734	P26718	NKG2D_HUMAN	Homo sapiens killer cell lectin-like receptor subfamily K, member 1 (KLRK1), mRNA.	28					T cell costimulation|natural killer cell activation	integral to plasma membrane	sugar binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)	9						TGAAAAATCACTCTTCTTCAG	0.363000														28			16		0	0	0.000566183	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr10:38654432A>G	uc010qex.1	+	4	599	c.524A>G	c.(523-525)aAt>aGt	p.N175S	HSD17B7P2_uc001izq.3_Non-coding_Transcript|HSD17B7P2_uc001izo.1_Non-coding_Transcript|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					Homo sapiens hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2 (HSD17B7P2), non-coding RNA.																		TCATCTCGCAATGCAAGGAAA	0.453000														83			8		0	0	0.000157383	0	0
MGRN1	23295	broad.mit.edu	37	16	4731570	4731570	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr16:4731570C>A	uc002cxa.3	+	12	1288	c.1151C>A	c.(1150-1152)cCt>cAt	p.P384H	MGRN1_uc002cwz.3_Missense_Mutation_p.P384H|MGRN1_uc010uxo.2_Missense_Mutation_p.P362H|MGRN1_uc010uxp.2_Missense_Mutation_p.P362H|MGRN1_uc010btw.3_Missense_Mutation_p.P363H|MGRN1_uc010uxq.2_Non-coding_Transcript	NM_015246	NP_056061	O60291	MGRN1_HUMAN	Homo sapiens mahogunin, ring finger 1 (MGRN1), transcript variant 1, mRNA.	384					endosome to lysosome transport|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of cAMP-mediated signaling|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.P383P(1)		endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						AGCGTCCCACCTGGCTACGAG	0.637000														47			23		3.5997e-14	3.03627e-13	0.000295444	1	0
F12	2161	broad.mit.edu	37	5	176830985	176830985	+	Silent	SNP	G	A	A	rs148322446		TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr5:176830985G>A	uc003mgo.4	-	9	1174	c.1125C>T	c.(1123-1125)ggC>ggT	p.G375G		NM_000505	NP_000496	P00748	FA12_HUMAN	Homo sapiens coagulation factor XII (Hageman factor) (F12), mRNA.	375	Peptidase S1.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCACCAGCCCGCCAACGACGC	0.706000									Hereditary Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		11			12		0	0	0.000308642	0	0
RXFP4	339403	broad.mit.edu	37	1	155912175	155912175	+	Silent	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:155912175G>A	uc010pgs.2	+	0	696	c.675G>A	c.(673-675)ctG>ctA	p.L225L		NM_181885	NP_871001	Q8TDU9	RL3R2_HUMAN	Homo sapiens relaxin/insulin-like family peptide receptor 4 (RXFP4), mRNA.	225						integral to membrane|plasma membrane	angiotensin type II receptor activity			endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	13	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CCAGCTACCTGCTGCTGCTGG	0.662000														77			7		0	0	0.000442599	0	0
PTPRA	5786	broad.mit.edu	37	20	3016489	3016489	+	Silent	SNP	G	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr20:3016489G>T	uc010zqd.2	+	20	2450	c.2133G>T	c.(2131-2133)gtG>gtT	p.V711V	PTPRA_uc002whj.3_Silent_p.V700V|PTPRA_uc002whk.3_Silent_p.V691V|PTPRA_uc002whl.3_Silent_p.V691V|PTPRA_uc002whm.3_Silent_p.V467V|PTPRA_uc002whn.3_Silent_p.V691V|PTPRA_uc002who.3_Silent_p.V363V	NM_002836	NP_002827	P18433	PTPRA_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, A (PTPRA), transcript variant 1, mRNA.	700	Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GGCCTGAAGTGGGCATCCCCA	0.587000														73			31		1.88708e-17	1.70276e-16	0.001512	1	0
ZCCHC10	54819	broad.mit.edu	37	5	132334373	132334373	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr5:132334373A>G	uc003kyh.3	-	4	492	c.481T>C	c.(481-483)Tct>Cct	p.S161P	ZCCHC10_uc003kyg.3_Missense_Mutation_p.S139P|ZCCHC10_uc011cxl.2_Missense_Mutation_p.S125P	NM_017665	NP_060135	Q8TBK6	ZCH10_HUMAN	Homo sapiens zinc finger, CCHC domain containing 10 (ZCCHC10), mRNA.	161	Ser-rich.						nucleic acid binding|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTGAATCAgaggaggaggaa	0.478000														55			19		0	0	0.000958276	0	0
TG	7038	broad.mit.edu	37	8	133931710	133931710	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr8:133931710T>G	uc003ytw.3	+	20	4509	c.4468T>G	c.(4468-4470)Tgt>Ggt	p.C1490G	TG_uc010mdw.3_Missense_Mutation_p.C249G|TG_uc011ljb.2_5'UTR|TG_uc003ytx.1_Non-coding_Transcript	NM_003235	NP_003226	P01266	THYG_HUMAN	Homo sapiens thyroglobulin (TG), mRNA.	1490					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAGCTTGGCCTGTGTCCCATG	0.478000														56			35		0	0	0.000953801	0	0
DSTYK	25778	broad.mit.edu	37	1	205132071	205132071	+	Silent	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:205132071G>A	uc001hbw.3	-	4	1685	c.1621C>T	c.(1621-1623)Cta>Tta	p.L541L	DSTYK_uc001hbx.3_Silent_p.L541L|DSTYK_uc001hby.1_Silent_p.L2L	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	Homo sapiens dual serine/threonine and tyrosine protein kinase (DSTYK), transcript variant 1, mRNA.	541						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						TGCTCCCATAGCATCCTTGTA	0.418000														66			53		0	0	0.000781405	0	0
T-Cell_Receptor_V-alpha_region	0	broad.mit.edu	37	14	22409618	22409618	+	Silent	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr14:22409618C>T	uc021rpl.1	+	1	151	c.108C>T	c.(106-108)gcC>gcT	p.A36A	TRA_uc021rpa.1_Intron|TCRA_uc001wbw.2_Intron|TCRA_uc021rpe.1_Intron|TCR-alpha_uc021rpg.1_Intron|AV2S1A1_uc010aiv.1_Intron|TCRA_uc021rpj.1_Intron|T-Cell_Receptor_V-alpha_region_uc001wck.3_Silent_p.A36A					SubName: Full=V-alpha 22; Flags: Precursor; Fragment;																		CAGAAGAGGCCTTCCTGACTA	0.483000														21			7		0	0	8.12818e-05	0	0
KRBA1	84626	broad.mit.edu	37	7	149416749	149416749	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr7:149416749C>T	uc003wfz.3	+	1	419	c.20C>T	c.(19-21)aCg>aTg	p.T7M	KRBA1_uc010lpj.3_Non-coding_Transcript|KRBA1_uc003wga.3_5'Flank	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	Homo sapiens KRAB-A domain containing 1 (KRBA1), mRNA.	7										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AACTACGAGACGCTGGTCTCT	0.657000														26			9		0	0	0.000442599	0	0
LEFTY1	10637	broad.mit.edu	37	1	226075314	226075314	+	Silent	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:226075314G>A	uc001hpo.3	-	2	602	c.522C>T	c.(520-522)ggC>ggT	p.G174G	PYCR2_uc010pvj.2_Silent_p.L283L|LEFTY1_uc009xej.2_3'UTR	NM_020997	NP_066277	O75610	LFTY1_HUMAN	Homo sapiens left-right determination factor 1 (LEFTY1), mRNA.	174					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding	p.G174V(1)		cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	10	Breast(184;0.197)					AGGCCTTCCAGCCGCTCTCGT	0.701000														29			20		0	0	0.000586117	0	0
TMC8	147138	broad.mit.edu	37	17	76133427	76133427	+	Silent	SNP	T	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr17:76133427T>G	uc002jup.2	+	9	1621	c.1239T>G	c.(1237-1239)gtT>gtG	p.V413V	TMC8_uc002juq.2_Silent_p.V190V|TMC8_uc010wtr.1_Intron|TMC8_uc002jur.1_5'Flank	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	Homo sapiens transmembrane channel-like 8 (TMC8), mRNA.	413						endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			GCTACAACGTTTGTGACTATC	0.587000														107			64		0	0	0.000781405	0	0
POTEH	23784	broad.mit.edu	37	22	16287673	16287673	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr22:16287673C>G	uc010gqp.2	-	0	265	c.213G>C	c.(211-213)tgG>tgC	p.W71C	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	Homo sapiens POTE ankyrin domain family, member H (POTEH), mRNA.	71								p.W71C(2)|p.P70T(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TCCCCCTGCACCAGGGGAAGC	0.582000														185			4		0	0	8.12818e-05	0	0
CXCR1	3577	broad.mit.edu	37	2	219029403	219029403	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr2:219029403A>T	uc021vwq.1	-	0	532	c.532T>A	c.(532-534)Tac>Aac	p.Y178N	CXCR1_uc002vhc.3_Missense_Mutation_p.Y178N|HV303425_uc021vwr.1_Non-coding_Transcript	NM_000634	NP_000625	P25024	CXCR1_HUMAN	Homo sapiens chemokine (C-X-C motif) receptor 1 (CXCR1), mRNA.	178					dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(3)	13						TTTGGATGGTAAGCCTGGCGG	0.512000														20			11		0	0	0.00136819	0	0
CDAN1	146059	broad.mit.edu	37	15	43024004	43024004	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr15:43024004C>T	uc001zql.3	-	10	1670	c.1553G>A	c.(1552-1554)gGt>gAt	p.G518D	CDAN1_uc001zqj.3_5'Flank|CDAN1_uc001zqk.3_5'UTR	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	Homo sapiens congenital dyserythropoietic anemia, type I (CDAN1), mRNA.	518						integral to membrane	protein binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	24		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		GCCCCCAGCACCACCAGGGCT	0.532000														53			25		0	0	0.000375601	0	0
FNIP2	57600	broad.mit.edu	37	4	159825696	159825696	+	Silent	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr4:159825696A>G	uc003iqe.4	+	16	3528	c.3345A>G	c.(3343-3345)taA>taG	p.*1115*	C4orf45_uc003iqf.1_Intron|C4orf45_uc010iqt.1_Intron	NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	Homo sapiens folliculin interacting protein 2 (FNIP2), mRNA.	0					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		TACTCTTATAAGCTAAAGCTC	0.388000														65			38		0	0	0.00128727	0	0
DDX20	11218	broad.mit.edu	37	1	112303729	112303729	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:112303729T>G	uc001ebs.3	+	5	1301	c.944T>G	c.(943-945)tTt>tGt	p.F315C	DDX20_uc010owf.2_Missense_Mutation_p.F77C|DDX20_uc001ebt.3_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 (DDX20), mRNA.	315	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTTTAGTCTTTTCTAATTTG	0.353000														47			32		0	0	0.000409698	0	0
RBM27	54439	broad.mit.edu	37	5	145610424	145610424	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr5:145610424C>A	uc003lnz.4	+	5	960	c.794C>A	c.(793-795)tCt>tAt	p.S265Y	RBM27_uc003lny.2_Missense_Mutation_p.S265Y	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	Homo sapiens RNA binding motif protein 27 (RBM27), mRNA.	265					mRNA processing	cytoplasm|nuclear speck	RNA binding|nucleotide binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(3)|endometrium(4)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AATCATAGCTCTTCCAATTCT	0.428000														45			31		5.60225e-13	4.62484e-12	0.00178596	1	0
ACACB	32	broad.mit.edu	37	12	109692084	109692084	+	Silent	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:109692084C>T	uc001tob.3	+	43	6230	c.6111C>T	c.(6109-6111)ctC>ctT	p.L2037L	ACACB_uc001toc.3_Silent_p.L2037L|ACACB_uc010sxl.1_Non-coding_Transcript|ACACB_uc001tod.3_Non-coding_Transcript|ACACB_uc010sxm.2_Silent_p.L703L	NM_001093	NP_001084	O00763	ACACB_HUMAN	Homo sapiens acetyl-CoA carboxylase beta (ACACB), mRNA.	2037	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	Golgi apparatus|cytosol|endomembrane system|membrane	ATP binding|acetyl-CoA carboxylase activity|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TTGAATTCCTCCCATCCAGAG	0.488000														123			79		0	0	0.000781405	0	0
HIST2H2BC	337873	broad.mit.edu	37	1	149821913	149821916	+	Frame_Shift_Del	DEL	GGAG	-	-			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:149821913_149821916delGGAG	uc021oxz.1	-	0	425_428	c.425_428delCTCC	c.(424-429)cctccgfs	p.P142fs	HIST2H2AA3_uc001esx.3_5'Flank|HIST2H3C_uc001esy.3_5'Flank					Homo sapiens histone cluster 2, H2bc (HIST2H2BC), non-coding RNA.																		GGCGACCCGCggagggagggaggg	0.593													---	11	---	---	5	---					
GNPTAB	79158	broad.mit.edu	37	12	102159058	102159058	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:102159058delA	uc001tit.3	-	12	1829	c.1637delT	c.(1636-1638)gtgfs	p.V546fs		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	Homo sapiens N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (GNPTAB), mRNA.	546					cell differentiation	Golgi membrane|integral to membrane|nucleus	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|metal ion binding|transcription factor binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						GAGAAGGATCACTTTATACAA	0.358													---	68	---	---	33	---					
LACTB	114294	broad.mit.edu	37	15	63414861	63414861	+	Frame_Shift_Del	DEL	G	-	-			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr15:63414861delG	uc002alw.3	+	1	456	c.384delG	c.(382-384)gtgfs	p.V128fs	LACTB_uc002alv.3_Frame_Shift_Del_p.V128fs	NM_032857	NP_116246	P83111	LACTB_HUMAN	Homo sapiens lactamase, beta (LACTB), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	128						mitochondrion	hydrolase activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(1)	12						CGGGCATAGTGGTTGGAGTTT	0.488													---	73	---	---	35	---					
EPG5	57724	broad.mit.edu	37	18	43464597	43464598	+	Frame_Shift_Ins	INS	-	AA	AA			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr18:43464597_43464598insAA	uc002lbm.3	-	29	5388_5389	c.5288_5289insTT	c.(5287-5289)ttcfs	p.F1763fs	EPG5_uc010xcr.1_Non-coding_Transcript|EPG5_uc010xcs.1_Non-coding_Transcript|EPG5_uc010xcq.1_Frame_Shift_Ins_p.F317fs|EPG5_uc002lbn.2_Frame_Shift_Ins_p.F638fs	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	Homo sapiens ectopic P-granules autophagy protein 5 homolog (C. elegans) (EPG5), mRNA.	1763					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TTAGCAGCATGAAAATCATATC	0.421													---	83	---	---	39	---					
